-- dump date 20140619_224358 -- class Genbank::misc_feature -- table misc_feature_note -- id note 452637000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 452637000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 452637000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637000004 Walker A motif; other site 452637000005 ATP binding site [chemical binding]; other site 452637000006 Walker B motif; other site 452637000007 arginine finger; other site 452637000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 452637000009 DnaA box-binding interface [nucleotide binding]; other site 452637000010 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 452637000011 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452637000012 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 452637000013 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 452637000014 nucleotide binding pocket [chemical binding]; other site 452637000015 K-X-D-G motif; other site 452637000016 catalytic site [active] 452637000017 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 452637000018 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 452637000019 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 452637000020 Dimer interface [polypeptide binding]; other site 452637000021 BRCT sequence motif; other site 452637000022 Predicted integral membrane protein [Function unknown]; Region: COG5652 452637000023 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 452637000024 putative catalytic site [active] 452637000025 putative metal binding site [ion binding]; other site 452637000026 putative phosphate binding site [ion binding]; other site 452637000027 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452637000028 ATP binding site [chemical binding]; other site 452637000029 putative Mg++ binding site [ion binding]; other site 452637000030 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452637000031 nucleotide binding region [chemical binding]; other site 452637000032 ATP-binding site [chemical binding]; other site 452637000033 Helicase associated domain (HA2); Region: HA2; pfam04408 452637000034 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 452637000035 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 452637000036 Repair protein; Region: Repair_PSII; cl01535 452637000037 Repair protein; Region: Repair_PSII; pfam04536 452637000038 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 452637000039 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 452637000040 FOG: CBS domain [General function prediction only]; Region: COG0517 452637000041 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 452637000042 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 452637000043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637000044 Walker A/P-loop; other site 452637000045 ATP binding site [chemical binding]; other site 452637000046 Q-loop/lid; other site 452637000047 ABC transporter signature motif; other site 452637000048 Walker B; other site 452637000049 D-loop; other site 452637000050 H-loop/switch region; other site 452637000051 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 452637000052 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 452637000053 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637000054 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637000055 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637000056 FtsX-like permease family; Region: FtsX; pfam02687 452637000057 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452637000058 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 452637000059 active site 452637000060 nucleotide binding site [chemical binding]; other site 452637000061 HIGH motif; other site 452637000062 KMSKS motif; other site 452637000063 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 452637000064 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452637000065 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452637000066 Walker A/P-loop; other site 452637000067 ATP binding site [chemical binding]; other site 452637000068 Q-loop/lid; other site 452637000069 ABC transporter signature motif; other site 452637000070 Walker B; other site 452637000071 D-loop; other site 452637000072 H-loop/switch region; other site 452637000073 Outer membrane efflux protein; Region: OEP; pfam02321 452637000074 Outer membrane efflux protein; Region: OEP; pfam02321 452637000075 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 452637000076 active site 452637000077 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 452637000078 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 452637000079 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 452637000080 Beta-lactamase; Region: Beta-lactamase; pfam00144 452637000081 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452637000082 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 452637000083 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 452637000084 active site 452637000085 Protein of unknown function DUF72; Region: DUF72; pfam01904 452637000086 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 452637000087 dimerization interface [polypeptide binding]; other site 452637000088 metal binding site [ion binding]; metal-binding site 452637000089 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 452637000090 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637000091 PAS domain; Region: PAS_9; pfam13426 452637000092 putative active site [active] 452637000093 heme pocket [chemical binding]; other site 452637000094 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452637000095 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452637000096 PAS domain S-box; Region: sensory_box; TIGR00229 452637000097 PAS fold; Region: PAS_4; pfam08448 452637000098 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 452637000099 putative active site [active] 452637000100 heme pocket [chemical binding]; other site 452637000101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637000102 PAS fold; Region: PAS_3; pfam08447 452637000103 putative active site [active] 452637000104 heme pocket [chemical binding]; other site 452637000105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637000106 dimer interface [polypeptide binding]; other site 452637000107 phosphorylation site [posttranslational modification] 452637000108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637000109 ATP binding site [chemical binding]; other site 452637000110 Mg2+ binding site [ion binding]; other site 452637000111 G-X-G motif; other site 452637000112 Response regulator receiver domain; Region: Response_reg; pfam00072 452637000113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637000114 active site 452637000115 phosphorylation site [posttranslational modification] 452637000116 intermolecular recognition site; other site 452637000117 dimerization interface [polypeptide binding]; other site 452637000118 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 452637000119 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 452637000120 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637000121 Walker A motif; other site 452637000122 ATP binding site [chemical binding]; other site 452637000123 Walker B motif; other site 452637000124 arginine finger; other site 452637000125 Helix-turn-helix domain; Region: HTH_28; pfam13518 452637000126 short chain dehydrogenase; Provisional; Region: PRK06701 452637000127 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 452637000128 NAD binding site [chemical binding]; other site 452637000129 metal binding site [ion binding]; metal-binding site 452637000130 active site 452637000131 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637000132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637000133 active site 452637000134 phosphorylation site [posttranslational modification] 452637000135 intermolecular recognition site; other site 452637000136 dimerization interface [polypeptide binding]; other site 452637000137 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637000138 DNA binding residues [nucleotide binding] 452637000139 dimerization interface [polypeptide binding]; other site 452637000140 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637000141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637000142 active site 452637000143 phosphorylation site [posttranslational modification] 452637000144 intermolecular recognition site; other site 452637000145 dimerization interface [polypeptide binding]; other site 452637000146 PAS fold; Region: PAS_4; pfam08448 452637000147 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452637000148 Histidine kinase; Region: HisKA_3; pfam07730 452637000149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637000150 ATP binding site [chemical binding]; other site 452637000151 Mg2+ binding site [ion binding]; other site 452637000152 G-X-G motif; other site 452637000153 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 452637000154 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 452637000155 putative DNA binding site [nucleotide binding]; other site 452637000156 putative homodimer interface [polypeptide binding]; other site 452637000157 RNA methyltransferase, RsmE family; Region: TIGR00046 452637000158 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 452637000159 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452637000160 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 452637000161 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 452637000162 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 452637000163 dimer interface [polypeptide binding]; other site 452637000164 active site 452637000165 CoA binding pocket [chemical binding]; other site 452637000166 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 452637000167 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 452637000168 E3 interaction surface; other site 452637000169 lipoyl attachment site [posttranslational modification]; other site 452637000170 e3 binding domain; Region: E3_binding; pfam02817 452637000171 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 452637000172 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 452637000173 CTP synthetase; Validated; Region: pyrG; PRK05380 452637000174 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 452637000175 Catalytic site [active] 452637000176 active site 452637000177 UTP binding site [chemical binding]; other site 452637000178 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 452637000179 active site 452637000180 putative oxyanion hole; other site 452637000181 catalytic triad [active] 452637000182 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 452637000183 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 452637000184 substrate binding site [chemical binding]; other site 452637000185 ATP binding site [chemical binding]; other site 452637000186 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 452637000187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637000188 Walker A/P-loop; other site 452637000189 ATP binding site [chemical binding]; other site 452637000190 Q-loop/lid; other site 452637000191 ABC transporter signature motif; other site 452637000192 Walker B; other site 452637000193 D-loop; other site 452637000194 H-loop/switch region; other site 452637000195 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 452637000196 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 452637000197 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 452637000198 AsnC family; Region: AsnC_trans_reg; pfam01037 452637000199 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 452637000200 Trp docking motif [polypeptide binding]; other site 452637000201 putative active site [active] 452637000202 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 452637000203 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 452637000204 BON domain; Region: BON; pfam04972 452637000205 Response regulator receiver domain; Region: Response_reg; pfam00072 452637000206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637000207 active site 452637000208 phosphorylation site [posttranslational modification] 452637000209 intermolecular recognition site; other site 452637000210 dimerization interface [polypeptide binding]; other site 452637000211 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 452637000212 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 452637000213 NAD binding site [chemical binding]; other site 452637000214 catalytic Zn binding site [ion binding]; other site 452637000215 structural Zn binding site [ion binding]; other site 452637000216 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 452637000217 putative hydrophobic ligand binding site [chemical binding]; other site 452637000218 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 452637000219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637000220 active site 452637000221 phosphorylation site [posttranslational modification] 452637000222 intermolecular recognition site; other site 452637000223 dimerization interface [polypeptide binding]; other site 452637000224 LytTr DNA-binding domain; Region: LytTR; smart00850 452637000225 Histidine kinase; Region: His_kinase; pfam06580 452637000226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637000227 ATP binding site [chemical binding]; other site 452637000228 Mg2+ binding site [ion binding]; other site 452637000229 G-X-G motif; other site 452637000230 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 452637000231 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 452637000232 nucleotide binding site [chemical binding]; other site 452637000233 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 452637000234 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 452637000235 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637000236 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 452637000237 FtsX-like permease family; Region: FtsX; pfam02687 452637000238 FtsX-like permease family; Region: FtsX; pfam02687 452637000239 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; pfam13366 452637000240 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 452637000241 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452637000242 Walker A/P-loop; other site 452637000243 ATP binding site [chemical binding]; other site 452637000244 Q-loop/lid; other site 452637000245 ABC transporter signature motif; other site 452637000246 Walker B; other site 452637000247 D-loop; other site 452637000248 H-loop/switch region; other site 452637000249 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 452637000250 active site 452637000251 catalytic triad [active] 452637000252 oxyanion hole [active] 452637000253 switch loop; other site 452637000254 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 452637000255 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452637000256 dimerization interface [polypeptide binding]; other site 452637000257 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 452637000258 cyclase homology domain; Region: CHD; cd07302 452637000259 nucleotidyl binding site; other site 452637000260 metal binding site [ion binding]; metal-binding site 452637000261 dimer interface [polypeptide binding]; other site 452637000262 rod shape-determining protein MreC; Provisional; Region: PRK13922 452637000263 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452637000264 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637000265 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637000266 DNA binding residues [nucleotide binding] 452637000267 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 452637000268 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 452637000269 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452637000270 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637000271 DNA binding residues [nucleotide binding] 452637000272 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 452637000273 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 452637000274 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 452637000275 PEP-CTERM motif; Region: VPEP; pfam07589 452637000276 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 452637000277 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 452637000278 putative catalytic cysteine [active] 452637000279 Biotin operon repressor [Transcription]; Region: BirA; COG1654 452637000280 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 452637000281 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 452637000282 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 452637000283 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 452637000284 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452637000285 Walker A/P-loop; other site 452637000286 ATP binding site [chemical binding]; other site 452637000287 Q-loop/lid; other site 452637000288 ABC transporter signature motif; other site 452637000289 Walker B; other site 452637000290 D-loop; other site 452637000291 H-loop/switch region; other site 452637000292 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 452637000293 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 452637000294 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 452637000295 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 452637000296 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 452637000297 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 452637000298 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 452637000299 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637000300 putative active site [active] 452637000301 PAS fold; Region: PAS_3; pfam08447 452637000302 heme pocket [chemical binding]; other site 452637000303 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637000304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637000305 putative active site [active] 452637000306 heme pocket [chemical binding]; other site 452637000307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637000308 dimer interface [polypeptide binding]; other site 452637000309 phosphorylation site [posttranslational modification] 452637000310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637000311 ATP binding site [chemical binding]; other site 452637000312 Mg2+ binding site [ion binding]; other site 452637000313 G-X-G motif; other site 452637000314 Response regulator receiver domain; Region: Response_reg; pfam00072 452637000315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637000316 active site 452637000317 phosphorylation site [posttranslational modification] 452637000318 intermolecular recognition site; other site 452637000319 dimerization interface [polypeptide binding]; other site 452637000320 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 452637000321 Sulfatase; Region: Sulfatase; cl17466 452637000322 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 452637000323 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 452637000324 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 452637000325 active site 452637000326 catalytic residues [active] 452637000327 metal binding site [ion binding]; metal-binding site 452637000328 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 452637000329 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 452637000330 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 452637000331 putative active site [active] 452637000332 PhoH-like protein; Region: PhoH; pfam02562 452637000333 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; pfam03767 452637000334 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 452637000335 DNA topoisomerase IV subunit A; Provisional; Region: PRK09631 452637000336 CAP-like domain; other site 452637000337 active site 452637000338 carboxyl-terminal processing protease; Provisional; Region: PLN00049 452637000339 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 452637000340 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 452637000341 Domain interface; other site 452637000342 Peptide binding site; other site 452637000343 Active site tetrad [active] 452637000344 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 452637000345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 452637000346 ATP binding site [chemical binding]; other site 452637000347 Mg2+ binding site [ion binding]; other site 452637000348 G-X-G motif; other site 452637000349 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 452637000350 ATP binding site [chemical binding]; other site 452637000351 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 452637000352 active site 452637000353 putative metal-binding site [ion binding]; other site 452637000354 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 452637000355 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 452637000356 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 452637000357 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 452637000358 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 452637000359 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 452637000360 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 452637000361 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 452637000362 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 452637000363 catalytic residues [active] 452637000364 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637000365 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637000366 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 452637000367 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 452637000368 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 452637000369 active site 452637000370 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452637000371 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 452637000372 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 452637000373 Nitrate and nitrite sensing; Region: NIT; pfam08376 452637000374 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 452637000375 dimer interface [polypeptide binding]; other site 452637000376 putative CheW interface [polypeptide binding]; other site 452637000377 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 452637000378 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 452637000379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452637000380 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 452637000381 Predicted membrane protein [Function unknown]; Region: COG4244 452637000382 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 452637000383 iron-sulfur cluster [ion binding]; other site 452637000384 [2Fe-2S] cluster binding site [ion binding]; other site 452637000385 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 452637000386 30S subunit binding site; other site 452637000387 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 452637000388 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637000389 Walker A motif; other site 452637000390 ATP binding site [chemical binding]; other site 452637000391 Walker B motif; other site 452637000392 arginine finger; other site 452637000393 Peptidase family M41; Region: Peptidase_M41; pfam01434 452637000394 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 452637000395 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452637000396 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 452637000397 mce related protein; Region: MCE; pfam02470 452637000398 mce related protein; Region: MCE; pfam02470 452637000399 Paraquat-inducible protein A; Region: PqiA; pfam04403 452637000400 Paraquat-inducible protein A; Region: PqiA; pfam04403 452637000401 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 452637000402 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 452637000403 elongation factor G; Reviewed; Region: PRK12740 452637000404 G1 box; other site 452637000405 putative GEF interaction site [polypeptide binding]; other site 452637000406 GTP/Mg2+ binding site [chemical binding]; other site 452637000407 Switch I region; other site 452637000408 G2 box; other site 452637000409 G3 box; other site 452637000410 Switch II region; other site 452637000411 G4 box; other site 452637000412 G5 box; other site 452637000413 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 452637000414 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 452637000415 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 452637000416 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 452637000417 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 452637000418 putative catalytic residue [active] 452637000419 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 452637000420 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 452637000421 catalytic residues [active] 452637000422 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 452637000423 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 452637000424 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452637000425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452637000426 Coenzyme A binding pocket [chemical binding]; other site 452637000427 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 452637000428 dimer interface [polypeptide binding]; other site 452637000429 putative CheW interface [polypeptide binding]; other site 452637000430 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 452637000431 catalytic core [active] 452637000432 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 452637000433 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 452637000434 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637000435 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 452637000436 PRC-barrel domain; Region: PRC; pfam05239 452637000437 DTW domain; Region: DTW; cl01221 452637000438 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 452637000439 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 452637000440 active site 452637000441 ADP/pyrophosphate binding site [chemical binding]; other site 452637000442 allosteric effector site; other site 452637000443 dimerization interface [polypeptide binding]; other site 452637000444 fructose-1,6-bisphosphate binding site; other site 452637000445 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 452637000446 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 452637000447 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 452637000448 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 452637000449 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452637000450 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452637000451 active site 452637000452 catalytic tetrad [active] 452637000453 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452637000454 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637000455 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 452637000456 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637000457 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 452637000458 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 452637000459 putative valine binding site [chemical binding]; other site 452637000460 dimer interface [polypeptide binding]; other site 452637000461 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 452637000462 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 452637000463 PYR/PP interface [polypeptide binding]; other site 452637000464 dimer interface [polypeptide binding]; other site 452637000465 TPP binding site [chemical binding]; other site 452637000466 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 452637000467 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 452637000468 TPP-binding site [chemical binding]; other site 452637000469 Right handed beta helix region; Region: Beta_helix; pfam13229 452637000470 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 452637000471 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 452637000472 ligand binding site [chemical binding]; other site 452637000473 flexible hinge region; other site 452637000474 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637000475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637000476 ATP binding site [chemical binding]; other site 452637000477 Mg2+ binding site [ion binding]; other site 452637000478 G-X-G motif; other site 452637000479 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452637000480 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 452637000481 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 452637000482 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 452637000483 dimer interface [polypeptide binding]; other site 452637000484 putative CheW interface [polypeptide binding]; other site 452637000485 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637000486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637000487 active site 452637000488 phosphorylation site [posttranslational modification] 452637000489 intermolecular recognition site; other site 452637000490 dimerization interface [polypeptide binding]; other site 452637000491 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 452637000492 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 452637000493 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 452637000494 NAD(P) binding site [chemical binding]; other site 452637000495 cell division protein DedD; Provisional; Region: PRK11633 452637000496 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 452637000497 PAS fold; Region: PAS_4; pfam08448 452637000498 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637000499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637000500 dimer interface [polypeptide binding]; other site 452637000501 phosphorylation site [posttranslational modification] 452637000502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637000503 ATP binding site [chemical binding]; other site 452637000504 Mg2+ binding site [ion binding]; other site 452637000505 G-X-G motif; other site 452637000506 Response regulator receiver domain; Region: Response_reg; pfam00072 452637000507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637000508 active site 452637000509 phosphorylation site [posttranslational modification] 452637000510 intermolecular recognition site; other site 452637000511 dimerization interface [polypeptide binding]; other site 452637000512 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 452637000513 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452637000514 NAD binding site [chemical binding]; other site 452637000515 putative substrate binding site 2 [chemical binding]; other site 452637000516 putative substrate binding site 1 [chemical binding]; other site 452637000517 active site 452637000518 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 452637000519 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 452637000520 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 452637000521 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 452637000522 glutamine binding [chemical binding]; other site 452637000523 catalytic triad [active] 452637000524 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 452637000525 ATP cone domain; Region: ATP-cone; pfam03477 452637000526 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 452637000527 nucleotide binding site/active site [active] 452637000528 HIT family signature motif; other site 452637000529 catalytic residue [active] 452637000530 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 452637000531 DNA protecting protein DprA; Region: dprA; TIGR00732 452637000532 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 452637000533 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 452637000534 putative substrate binding site [chemical binding]; other site 452637000535 putative ATP binding site [chemical binding]; other site 452637000536 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 452637000537 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 452637000538 active site 452637000539 hydrophilic channel; other site 452637000540 dimerization interface [polypeptide binding]; other site 452637000541 catalytic residues [active] 452637000542 active site lid [active] 452637000543 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 452637000544 dimer interface [polypeptide binding]; other site 452637000545 Citrate synthase; Region: Citrate_synt; pfam00285 452637000546 active site 452637000547 citrylCoA binding site [chemical binding]; other site 452637000548 NADH binding [chemical binding]; other site 452637000549 cationic pore residues; other site 452637000550 oxalacetate/citrate binding site [chemical binding]; other site 452637000551 coenzyme A binding site [chemical binding]; other site 452637000552 catalytic triad [active] 452637000553 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 452637000554 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 452637000555 putative active site [active] 452637000556 oxyanion strand; other site 452637000557 catalytic triad [active] 452637000558 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 452637000559 putative active site pocket [active] 452637000560 4-fold oligomerization interface [polypeptide binding]; other site 452637000561 metal binding residues [ion binding]; metal-binding site 452637000562 3-fold/trimer interface [polypeptide binding]; other site 452637000563 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 452637000564 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452637000565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637000566 homodimer interface [polypeptide binding]; other site 452637000567 catalytic residue [active] 452637000568 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 452637000569 histidinol dehydrogenase; Region: hisD; TIGR00069 452637000570 NAD binding site [chemical binding]; other site 452637000571 dimerization interface [polypeptide binding]; other site 452637000572 product binding site; other site 452637000573 substrate binding site [chemical binding]; other site 452637000574 zinc binding site [ion binding]; other site 452637000575 catalytic residues [active] 452637000576 GMP synthase; Reviewed; Region: guaA; PRK00074 452637000577 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 452637000578 AMP/PPi binding site [chemical binding]; other site 452637000579 candidate oxyanion hole; other site 452637000580 catalytic triad [active] 452637000581 potential glutamine specificity residues [chemical binding]; other site 452637000582 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 452637000583 ATP Binding subdomain [chemical binding]; other site 452637000584 Ligand Binding sites [chemical binding]; other site 452637000585 Dimerization subdomain; other site 452637000586 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 452637000587 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452637000588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637000589 putative substrate translocation pore; other site 452637000590 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 452637000591 dimerization interface [polypeptide binding]; other site 452637000592 metal binding site [ion binding]; metal-binding site 452637000593 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 452637000594 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 452637000595 active site 452637000596 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 452637000597 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 452637000598 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 452637000599 alphaNTD homodimer interface [polypeptide binding]; other site 452637000600 alphaNTD - beta interaction site [polypeptide binding]; other site 452637000601 alphaNTD - beta' interaction site [polypeptide binding]; other site 452637000602 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 452637000603 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 452637000604 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 452637000605 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 452637000606 RNA binding surface [nucleotide binding]; other site 452637000607 30S ribosomal protein S11; Validated; Region: PRK05309 452637000608 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 452637000609 30S ribosomal protein S13; Region: bact_S13; TIGR03631 452637000610 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 452637000611 active site 452637000612 adenylate kinase; Reviewed; Region: adk; PRK00279 452637000613 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 452637000614 SecY translocase; Region: SecY; pfam00344 452637000615 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 452637000616 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 452637000617 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 452637000618 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 452637000619 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 452637000620 23S rRNA interface [nucleotide binding]; other site 452637000621 L21e interface [polypeptide binding]; other site 452637000622 5S rRNA interface [nucleotide binding]; other site 452637000623 L27 interface [polypeptide binding]; other site 452637000624 L5 interface [polypeptide binding]; other site 452637000625 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 452637000626 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 452637000627 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 452637000628 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 452637000629 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 452637000630 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 452637000631 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 452637000632 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 452637000633 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 452637000634 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 452637000635 RNA binding site [nucleotide binding]; other site 452637000636 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 452637000637 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 452637000638 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 452637000639 putative translocon interaction site; other site 452637000640 23S rRNA interface [nucleotide binding]; other site 452637000641 signal recognition particle (SRP54) interaction site; other site 452637000642 L23 interface [polypeptide binding]; other site 452637000643 trigger factor interaction site; other site 452637000644 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 452637000645 23S rRNA interface [nucleotide binding]; other site 452637000646 5S rRNA interface [nucleotide binding]; other site 452637000647 putative antibiotic binding site [chemical binding]; other site 452637000648 L25 interface [polypeptide binding]; other site 452637000649 L27 interface [polypeptide binding]; other site 452637000650 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 452637000651 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 452637000652 G-X-X-G motif; other site 452637000653 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 452637000654 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 452637000655 putative translocon binding site; other site 452637000656 protein-rRNA interface [nucleotide binding]; other site 452637000657 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 452637000658 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 452637000659 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 452637000660 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 452637000661 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 452637000662 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 452637000663 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 452637000664 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 452637000665 elongation factor G; Reviewed; Region: PRK00007 452637000666 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 452637000667 G1 box; other site 452637000668 putative GEF interaction site [polypeptide binding]; other site 452637000669 GTP/Mg2+ binding site [chemical binding]; other site 452637000670 Switch I region; other site 452637000671 G2 box; other site 452637000672 G3 box; other site 452637000673 Switch II region; other site 452637000674 G4 box; other site 452637000675 G5 box; other site 452637000676 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 452637000677 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 452637000678 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 452637000679 30S ribosomal protein S7; Validated; Region: PRK05302 452637000680 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 452637000681 S17 interaction site [polypeptide binding]; other site 452637000682 S8 interaction site; other site 452637000683 16S rRNA interaction site [nucleotide binding]; other site 452637000684 streptomycin interaction site [chemical binding]; other site 452637000685 23S rRNA interaction site [nucleotide binding]; other site 452637000686 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 452637000687 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 452637000688 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 452637000689 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 452637000690 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 452637000691 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 452637000692 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 452637000693 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 452637000694 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 452637000695 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 452637000696 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 452637000697 DNA binding site [nucleotide binding] 452637000698 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 452637000699 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 452637000700 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 452637000701 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 452637000702 RNA polymerase beta subunit; Provisional; Region: rpoB; CHL00207 452637000703 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 452637000704 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 452637000705 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 452637000706 RPB3 interaction site [polypeptide binding]; other site 452637000707 RPB1 interaction site [polypeptide binding]; other site 452637000708 RPB11 interaction site [polypeptide binding]; other site 452637000709 RPB10 interaction site [polypeptide binding]; other site 452637000710 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 452637000711 core dimer interface [polypeptide binding]; other site 452637000712 peripheral dimer interface [polypeptide binding]; other site 452637000713 L10 interface [polypeptide binding]; other site 452637000714 L11 interface [polypeptide binding]; other site 452637000715 putative EF-Tu interaction site [polypeptide binding]; other site 452637000716 putative EF-G interaction site [polypeptide binding]; other site 452637000717 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 452637000718 23S rRNA interface [nucleotide binding]; other site 452637000719 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 452637000720 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 452637000721 mRNA/rRNA interface [nucleotide binding]; other site 452637000722 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 452637000723 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 452637000724 L7/L12 interface [polypeptide binding]; other site 452637000725 23S rRNA interface [nucleotide binding]; other site 452637000726 L25 interface [polypeptide binding]; other site 452637000727 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 452637000728 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 452637000729 putative homodimer interface [polypeptide binding]; other site 452637000730 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 452637000731 heterodimer interface [polypeptide binding]; other site 452637000732 homodimer interface [polypeptide binding]; other site 452637000733 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 452637000734 elongation factor Tu; Reviewed; Region: PRK00049 452637000735 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 452637000736 G1 box; other site 452637000737 GEF interaction site [polypeptide binding]; other site 452637000738 GTP/Mg2+ binding site [chemical binding]; other site 452637000739 Switch I region; other site 452637000740 G2 box; other site 452637000741 G3 box; other site 452637000742 Switch II region; other site 452637000743 G4 box; other site 452637000744 G5 box; other site 452637000745 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 452637000746 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 452637000747 Antibiotic Binding Site [chemical binding]; other site 452637000748 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 452637000749 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 452637000750 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 452637000751 Peptidase family M48; Region: Peptidase_M48; cl12018 452637000752 Fe-S metabolism associated domain; Region: SufE; cl00951 452637000753 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 452637000754 active site 452637000755 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 452637000756 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 452637000757 putative ATP binding site [chemical binding]; other site 452637000758 putative substrate interface [chemical binding]; other site 452637000759 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 452637000760 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 452637000761 putative active site [active] 452637000762 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 452637000763 metal binding site [ion binding]; metal-binding site 452637000764 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 452637000765 AAA domain; Region: AAA_28; pfam13521 452637000766 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 452637000767 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236 452637000768 redox-dependent activation switch; other site 452637000769 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 452637000770 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 452637000771 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637000772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637000773 active site 452637000774 phosphorylation site [posttranslational modification] 452637000775 intermolecular recognition site; other site 452637000776 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637000777 dimerization interface [polypeptide binding]; other site 452637000778 DNA binding residues [nucleotide binding] 452637000779 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637000780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637000781 dimer interface [polypeptide binding]; other site 452637000782 phosphorylation site [posttranslational modification] 452637000783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637000784 ATP binding site [chemical binding]; other site 452637000785 Mg2+ binding site [ion binding]; other site 452637000786 G-X-G motif; other site 452637000787 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 452637000788 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 452637000789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637000790 S-adenosylmethionine binding site [chemical binding]; other site 452637000791 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 452637000792 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 452637000793 active site 452637000794 methionine sulfoxide reductase A; Provisional; Region: PRK14054 452637000795 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 452637000796 putative ADP-ribose binding site [chemical binding]; other site 452637000797 putative active site [active] 452637000798 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 452637000799 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637000800 Walker A/P-loop; other site 452637000801 ATP binding site [chemical binding]; other site 452637000802 Q-loop/lid; other site 452637000803 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452637000804 ABC transporter; Region: ABC_tran_2; pfam12848 452637000805 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452637000806 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 452637000807 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 452637000808 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 452637000809 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 452637000810 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637000811 binding surface 452637000812 TPR motif; other site 452637000813 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 452637000814 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 452637000815 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 452637000816 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; cl17557 452637000817 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 452637000818 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 452637000819 putative active site [active] 452637000820 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 452637000821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637000822 Walker A motif; other site 452637000823 ATP binding site [chemical binding]; other site 452637000824 Walker B motif; other site 452637000825 arginine finger; other site 452637000826 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 452637000827 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 452637000828 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 452637000829 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 452637000830 active site 452637000831 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 452637000832 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 452637000833 phosphodiesterase; Provisional; Region: PRK12704 452637000834 KH domain; Region: KH_1; pfam00013 452637000835 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452637000836 Zn2+ binding site [ion binding]; other site 452637000837 Mg2+ binding site [ion binding]; other site 452637000838 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 452637000839 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 452637000840 Protein of unknown function (DUF3485); Region: DUF3485; cl11827 452637000841 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452637000842 Sel1-like repeats; Region: SEL1; smart00671 452637000843 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 452637000844 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 452637000845 nucleophile elbow; other site 452637000846 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637000847 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452637000848 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 452637000849 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 452637000850 Ligand binding site; other site 452637000851 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452637000852 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637000853 O-Antigen ligase; Region: Wzy_C; pfam04932 452637000854 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 452637000855 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 452637000856 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 452637000857 homodimer interface [polypeptide binding]; other site 452637000858 oligonucleotide binding site [chemical binding]; other site 452637000859 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 452637000860 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452637000861 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637000862 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637000863 DNA binding residues [nucleotide binding] 452637000864 Methyltransferase domain; Region: Methyltransf_31; pfam13847 452637000865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637000866 S-adenosylmethionine binding site [chemical binding]; other site 452637000867 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 452637000868 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 452637000869 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 452637000870 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 452637000871 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 452637000872 Probable Catalytic site; other site 452637000873 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 452637000874 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452637000875 FeS/SAM binding site; other site 452637000876 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 452637000877 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452637000878 active site 452637000879 Protein of unknown function, DUF547; Region: DUF547; pfam04784 452637000880 Uncharacterized conserved protein [Function unknown]; Region: COG0398 452637000881 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 452637000882 mercuric reductase; Validated; Region: PRK06370 452637000883 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452637000884 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 452637000885 Immunoglobulin domain; Region: Ig_2; pfam13895 452637000886 FOG: WD40 repeat [General function prediction only]; Region: COG2319 452637000887 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637000888 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637000889 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637000890 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637000891 Immunoglobulin C-2 Type; Region: IGc2; smart00408 452637000892 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637000893 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637000894 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637000895 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637000896 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637000897 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637000898 Immunoglobulin I-set domain; Region: I-set; pfam07679 452637000899 Immunoglobulin domain; Region: Ig; cd00096 452637000900 Immunoglobulin domain; Region: Ig; cl11960 452637000901 Immunoglobulin I-set domain; Region: I-set; pfam07679 452637000902 Putative Ig domain; Region: He_PIG; pfam05345 452637000903 Cadherin repeat-like domain; Region: CA_like; cl15786 452637000904 Ca2+ binding site [ion binding]; other site 452637000905 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 452637000906 Cadherin repeat-like domain; Region: CA_like; cl15786 452637000907 Ca2+ binding site [ion binding]; other site 452637000908 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 452637000909 Immunoglobulin domain; Region: Ig_2; pfam13895 452637000910 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 452637000911 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 452637000912 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 452637000913 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637000914 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452637000915 dimerization interface [polypeptide binding]; other site 452637000916 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637000917 dimer interface [polypeptide binding]; other site 452637000918 phosphorylation site [posttranslational modification] 452637000919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637000920 ATP binding site [chemical binding]; other site 452637000921 Mg2+ binding site [ion binding]; other site 452637000922 G-X-G motif; other site 452637000923 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452637000924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637000925 active site 452637000926 phosphorylation site [posttranslational modification] 452637000927 intermolecular recognition site; other site 452637000928 dimerization interface [polypeptide binding]; other site 452637000929 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452637000930 DNA binding site [nucleotide binding] 452637000931 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637000932 FtsX-like permease family; Region: FtsX; pfam02687 452637000933 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637000934 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452637000935 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452637000936 Walker A/P-loop; other site 452637000937 ATP binding site [chemical binding]; other site 452637000938 Q-loop/lid; other site 452637000939 ABC transporter signature motif; other site 452637000940 Walker B; other site 452637000941 D-loop; other site 452637000942 H-loop/switch region; other site 452637000943 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 452637000944 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 452637000945 HlyD family secretion protein; Region: HlyD_3; pfam13437 452637000946 von Willebrand factor; Region: vWF_A; pfam12450 452637000947 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 452637000948 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 452637000949 metal ion-dependent adhesion site (MIDAS); other site 452637000950 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 452637000951 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452637000952 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637000953 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 452637000954 Glycosyl hydrolase family 62, characterized arabinofuranosidases; Region: GH62; cd08987 452637000955 active site 452637000956 Immunoglobulin I-set domain; Region: I-set; pfam07679 452637000957 Immunoglobulin domain; Region: Ig; cd00096 452637000958 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 452637000959 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 452637000960 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 452637000961 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 452637000962 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 452637000963 active site 452637000964 dimerization interface [polypeptide binding]; other site 452637000965 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 452637000966 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452637000967 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 452637000968 dimerization interface [polypeptide binding]; other site 452637000969 substrate binding pocket [chemical binding]; other site 452637000970 Isochorismatase family; Region: Isochorismatase; pfam00857 452637000971 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 452637000972 catalytic triad [active] 452637000973 conserved cis-peptide bond; other site 452637000974 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637000975 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637000976 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 452637000977 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 452637000978 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 452637000979 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 452637000980 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 452637000981 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 452637000982 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 452637000983 catalytic site [active] 452637000984 active site 452637000985 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 452637000986 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 452637000987 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452637000988 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 452637000989 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 452637000990 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 452637000991 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 452637000992 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 452637000993 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 452637000994 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452637000995 Coenzyme A binding pocket [chemical binding]; other site 452637000996 Uncharacterized conserved protein [Function unknown]; Region: COG4933 452637000997 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452637000998 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452637000999 non-specific DNA binding site [nucleotide binding]; other site 452637001000 salt bridge; other site 452637001001 sequence-specific DNA binding site [nucleotide binding]; other site 452637001002 RibD C-terminal domain; Region: RibD_C; cl17279 452637001003 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 452637001004 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 452637001005 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452637001006 Syndecan domain; Region: Syndecan; pfam01034 452637001007 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452637001008 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452637001009 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452637001010 active site 452637001011 ATP binding site [chemical binding]; other site 452637001012 substrate binding site [chemical binding]; other site 452637001013 activation loop (A-loop); other site 452637001014 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 452637001015 structural tetrad; other site 452637001016 FOG: WD40 repeat [General function prediction only]; Region: COG2319 452637001017 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 452637001018 structural tetrad; other site 452637001019 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 452637001020 Glycosyl hydrolase family 43; Region: GH43_3; cd08982 452637001021 active site 452637001022 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 452637001023 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 452637001024 dimer interface [polypeptide binding]; other site 452637001025 putative CheW interface [polypeptide binding]; other site 452637001026 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 452637001027 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637001028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637001029 dimer interface [polypeptide binding]; other site 452637001030 phosphorylation site [posttranslational modification] 452637001031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637001032 ATP binding site [chemical binding]; other site 452637001033 Mg2+ binding site [ion binding]; other site 452637001034 G-X-G motif; other site 452637001035 Response regulator receiver domain; Region: Response_reg; pfam00072 452637001036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637001037 active site 452637001038 phosphorylation site [posttranslational modification] 452637001039 intermolecular recognition site; other site 452637001040 dimerization interface [polypeptide binding]; other site 452637001041 Response regulator receiver domain; Region: Response_reg; pfam00072 452637001042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637001043 active site 452637001044 phosphorylation site [posttranslational modification] 452637001045 intermolecular recognition site; other site 452637001046 dimerization interface [polypeptide binding]; other site 452637001047 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 452637001048 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637001049 putative active site [active] 452637001050 heme pocket [chemical binding]; other site 452637001051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637001052 dimer interface [polypeptide binding]; other site 452637001053 phosphorylation site [posttranslational modification] 452637001054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637001055 ATP binding site [chemical binding]; other site 452637001056 Mg2+ binding site [ion binding]; other site 452637001057 G-X-G motif; other site 452637001058 GAF domain; Region: GAF; pfam01590 452637001059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637001060 PAS fold; Region: PAS_3; pfam08447 452637001061 putative active site [active] 452637001062 heme pocket [chemical binding]; other site 452637001063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637001064 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637001065 dimer interface [polypeptide binding]; other site 452637001066 phosphorylation site [posttranslational modification] 452637001067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637001068 ATP binding site [chemical binding]; other site 452637001069 Mg2+ binding site [ion binding]; other site 452637001070 G-X-G motif; other site 452637001071 Response regulator receiver domain; Region: Response_reg; pfam00072 452637001072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637001073 active site 452637001074 phosphorylation site [posttranslational modification] 452637001075 intermolecular recognition site; other site 452637001076 dimerization interface [polypeptide binding]; other site 452637001077 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637001078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637001079 active site 452637001080 phosphorylation site [posttranslational modification] 452637001081 intermolecular recognition site; other site 452637001082 dimerization interface [polypeptide binding]; other site 452637001083 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637001084 DNA binding residues [nucleotide binding] 452637001085 dimerization interface [polypeptide binding]; other site 452637001086 NAD-dependent deacetylase; Provisional; Region: PRK00481 452637001087 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 452637001088 NAD+ binding site [chemical binding]; other site 452637001089 substrate binding site [chemical binding]; other site 452637001090 Zn binding site [ion binding]; other site 452637001091 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 452637001092 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452637001093 FeS/SAM binding site; other site 452637001094 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 452637001095 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452637001096 FeS/SAM binding site; other site 452637001097 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 452637001098 substrate binding site [chemical binding]; other site 452637001099 active site 452637001100 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 452637001101 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452637001102 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452637001103 catalytic residue [active] 452637001104 FG-GAP repeat; Region: FG-GAP_2; pfam14312 452637001105 FG-GAP repeat; Region: FG-GAP_2; pfam14312 452637001106 FG-GAP repeat; Region: FG-GAP_2; pfam14312 452637001107 FG-GAP repeat; Region: FG-GAP_2; pfam14312 452637001108 FG-GAP repeat; Region: FG-GAP_2; pfam14312 452637001109 FG-GAP repeat; Region: FG-GAP_2; pfam14312 452637001110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637001111 dimer interface [polypeptide binding]; other site 452637001112 phosphorylation site [posttranslational modification] 452637001113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637001114 ATP binding site [chemical binding]; other site 452637001115 G-X-G motif; other site 452637001116 Pectic acid lyase; Region: Pec_lyase; pfam09492 452637001117 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 452637001118 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 452637001119 Moco binding site; other site 452637001120 metal coordination site [ion binding]; other site 452637001121 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 452637001122 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 452637001123 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 452637001124 dimer interface [polypeptide binding]; other site 452637001125 putative CheW interface [polypeptide binding]; other site 452637001126 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 452637001127 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 452637001128 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637001129 PAS domain; Region: PAS_9; pfam13426 452637001130 putative active site [active] 452637001131 heme pocket [chemical binding]; other site 452637001132 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637001133 PAS fold; Region: PAS_3; pfam08447 452637001134 putative active site [active] 452637001135 heme pocket [chemical binding]; other site 452637001136 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637001137 PAS fold; Region: PAS_3; pfam08447 452637001138 putative active site [active] 452637001139 heme pocket [chemical binding]; other site 452637001140 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637001141 PAS fold; Region: PAS_3; pfam08447 452637001142 putative active site [active] 452637001143 heme pocket [chemical binding]; other site 452637001144 PAS fold; Region: PAS_4; pfam08448 452637001145 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637001146 dimer interface [polypeptide binding]; other site 452637001147 phosphorylation site [posttranslational modification] 452637001148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637001149 ATP binding site [chemical binding]; other site 452637001150 Mg2+ binding site [ion binding]; other site 452637001151 G-X-G motif; other site 452637001152 Response regulator receiver domain; Region: Response_reg; pfam00072 452637001153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637001154 active site 452637001155 phosphorylation site [posttranslational modification] 452637001156 intermolecular recognition site; other site 452637001157 dimerization interface [polypeptide binding]; other site 452637001158 flagellin; Provisional; Region: PRK12804 452637001159 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 452637001160 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 452637001161 Global regulator protein family; Region: CsrA; pfam02599 452637001162 FliW protein; Region: FliW; pfam02623 452637001163 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 452637001164 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 452637001165 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 452637001166 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 452637001167 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 452637001168 FlgN protein; Region: FlgN; pfam05130 452637001169 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 452637001170 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 452637001171 Flagellar L-ring protein; Region: FlgH; pfam02107 452637001172 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 452637001173 flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170 452637001174 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 452637001175 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 452637001176 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 452637001177 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 452637001178 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 452637001179 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 452637001180 ligand binding site [chemical binding]; other site 452637001181 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 452637001182 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 452637001183 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 452637001184 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637001185 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 452637001186 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637001187 DNA binding residues [nucleotide binding] 452637001188 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 452637001189 Flagellar GTP-binding protein [Cell motility and secretion]; Region: FlhF; COG1419 452637001190 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 452637001191 FHIPEP family; Region: FHIPEP; pfam00771 452637001192 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 452637001193 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 452637001194 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 452637001195 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 452637001196 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 452637001197 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 452637001198 flagellar motor switch protein FliN; Region: fliN; TIGR02480 452637001199 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 452637001200 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 452637001201 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 452637001202 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 452637001203 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 452637001204 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 452637001205 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 452637001206 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 452637001207 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 452637001208 Walker A motif/ATP binding site; other site 452637001209 Walker B motif; other site 452637001210 Flagellar assembly protein FliH; Region: FliH; pfam02108 452637001211 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 452637001212 MgtE intracellular N domain; Region: MgtE_N; cl15244 452637001213 FliG C-terminal domain; Region: FliG_C; pfam01706 452637001214 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 452637001215 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 452637001216 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 452637001217 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 452637001218 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 452637001219 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 452637001220 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 452637001221 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 452637001222 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 452637001223 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 452637001224 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 452637001225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637001226 S-adenosylmethionine binding site [chemical binding]; other site 452637001227 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 452637001228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637001229 active site 452637001230 phosphorylation site [posttranslational modification] 452637001231 intermolecular recognition site; other site 452637001232 dimerization interface [polypeptide binding]; other site 452637001233 CheB methylesterase; Region: CheB_methylest; pfam01339 452637001234 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 452637001235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637001236 active site 452637001237 phosphorylation site [posttranslational modification] 452637001238 intermolecular recognition site; other site 452637001239 dimerization interface [polypeptide binding]; other site 452637001240 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452637001241 Zn2+ binding site [ion binding]; other site 452637001242 Mg2+ binding site [ion binding]; other site 452637001243 CheD chemotactic sensory transduction; Region: CheD; cl00810 452637001244 HDOD domain; Region: HDOD; pfam08668 452637001245 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 452637001246 putative binding surface; other site 452637001247 active site 452637001248 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 452637001249 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 452637001250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637001251 ATP binding site [chemical binding]; other site 452637001252 Mg2+ binding site [ion binding]; other site 452637001253 G-X-G motif; other site 452637001254 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 452637001255 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 452637001256 Response regulator receiver domain; Region: Response_reg; pfam00072 452637001257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637001258 active site 452637001259 phosphorylation site [posttranslational modification] 452637001260 intermolecular recognition site; other site 452637001261 dimerization interface [polypeptide binding]; other site 452637001262 Response regulator receiver domain; Region: Response_reg; pfam00072 452637001263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637001264 active site 452637001265 phosphorylation site [posttranslational modification] 452637001266 intermolecular recognition site; other site 452637001267 dimerization interface [polypeptide binding]; other site 452637001268 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 452637001269 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 452637001270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637001271 active site 452637001272 phosphorylation site [posttranslational modification] 452637001273 intermolecular recognition site; other site 452637001274 dimerization interface [polypeptide binding]; other site 452637001275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637001276 Walker A motif; other site 452637001277 ATP binding site [chemical binding]; other site 452637001278 Walker B motif; other site 452637001279 arginine finger; other site 452637001280 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 452637001281 Response regulator receiver domain; Region: Response_reg; pfam00072 452637001282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637001283 active site 452637001284 phosphorylation site [posttranslational modification] 452637001285 intermolecular recognition site; other site 452637001286 dimerization interface [polypeptide binding]; other site 452637001287 Flagellar protein FliS; Region: FliS; cl00654 452637001288 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 452637001289 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 452637001290 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 452637001291 flagellin; Provisional; Region: PRK12802 452637001292 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 452637001293 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 452637001294 flagellin; Provisional; Region: PRK12802 452637001295 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 452637001296 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 452637001297 flagellin; Provisional; Region: PRK12802 452637001298 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 452637001299 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 452637001300 flagellin; Provisional; Region: PRK12802 452637001301 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 452637001302 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 452637001303 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 452637001304 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 452637001305 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 452637001306 dimer interface [polypeptide binding]; other site 452637001307 active site 452637001308 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 452637001309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452637001310 active site 452637001311 motif I; other site 452637001312 motif II; other site 452637001313 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 452637001314 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 452637001315 substrate binding site; other site 452637001316 dimer interface; other site 452637001317 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 452637001318 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 452637001319 classical (c) SDRs; Region: SDR_c; cd05233 452637001320 NAD(P) binding site [chemical binding]; other site 452637001321 active site 452637001322 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 452637001323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001324 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452637001325 binding surface 452637001326 TPR motif; other site 452637001327 TPR repeat; Region: TPR_11; pfam13414 452637001328 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 452637001329 binding surface 452637001330 TPR motif; other site 452637001331 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 452637001332 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 452637001333 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 452637001334 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 452637001335 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001336 TPR motif; other site 452637001337 binding surface 452637001338 HDOD domain; Region: HDOD; pfam08668 452637001339 Tetratricopeptide repeat; Region: TPR_16; pfam13432 452637001340 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001341 binding surface 452637001342 TPR motif; other site 452637001343 TPR repeat; Region: TPR_11; pfam13414 452637001344 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001345 binding surface 452637001346 TPR repeat; Region: TPR_11; pfam13414 452637001347 TPR motif; other site 452637001348 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452637001349 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 452637001350 HDOD domain; Region: HDOD; pfam08668 452637001351 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452637001352 Zn2+ binding site [ion binding]; other site 452637001353 Mg2+ binding site [ion binding]; other site 452637001354 PAS fold; Region: PAS_4; pfam08448 452637001355 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637001356 putative active site [active] 452637001357 heme pocket [chemical binding]; other site 452637001358 histidine kinase; Provisional; Region: PRK13557 452637001359 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637001360 putative active site [active] 452637001361 heme pocket [chemical binding]; other site 452637001362 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637001363 dimer interface [polypeptide binding]; other site 452637001364 phosphorylation site [posttranslational modification] 452637001365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637001366 ATP binding site [chemical binding]; other site 452637001367 Mg2+ binding site [ion binding]; other site 452637001368 G-X-G motif; other site 452637001369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637001370 active site 452637001371 phosphorylation site [posttranslational modification] 452637001372 intermolecular recognition site; other site 452637001373 dimerization interface [polypeptide binding]; other site 452637001374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001375 binding surface 452637001376 TPR motif; other site 452637001377 Competence protein; Region: Competence; pfam03772 452637001378 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 452637001379 putative catalytic site [active] 452637001380 putative metal binding site [ion binding]; other site 452637001381 putative phosphate binding site [ion binding]; other site 452637001382 Thymidylate synthase complementing protein; Region: Thy1; cl03630 452637001383 Thymidylate synthase complementing protein; Region: Thy1; cl03630 452637001384 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 452637001385 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452637001386 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 452637001387 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452637001388 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NuoL; COG1009 452637001389 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 452637001390 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452637001391 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 452637001392 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 452637001393 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 452637001394 4Fe-4S binding domain; Region: Fer4; pfam00037 452637001395 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 452637001396 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 452637001397 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 452637001398 catalytic loop [active] 452637001399 iron binding site [ion binding]; other site 452637001400 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 452637001401 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 452637001402 Molybdopterin oxidoreductase; Region: Molybdopterin; pfam00384 452637001403 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 452637001404 SLBB domain; Region: SLBB; pfam10531 452637001405 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 452637001406 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 452637001407 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 452637001408 putative dimer interface [polypeptide binding]; other site 452637001409 [2Fe-2S] cluster binding site [ion binding]; other site 452637001410 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 452637001411 NADH dehydrogenase subunit D; Validated; Region: PRK06075 452637001412 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 452637001413 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 452637001414 NADH dehydrogenase subunit B; Provisional; Region: PRK14815 452637001415 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 452637001416 Family description; Region: VCBS; pfam13517 452637001417 Family description; Region: VCBS; pfam13517 452637001418 Family description; Region: VCBS; pfam13517 452637001419 Family description; Region: VCBS; pfam13517 452637001420 Family description; Region: VCBS; pfam13517 452637001421 Family description; Region: VCBS; pfam13517 452637001422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001423 binding surface 452637001424 TPR motif; other site 452637001425 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 452637001426 TPR repeat; Region: TPR_11; pfam13414 452637001427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001428 TPR motif; other site 452637001429 binding surface 452637001430 TPR repeat; Region: TPR_11; pfam13414 452637001431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001432 TPR motif; other site 452637001433 binding surface 452637001434 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 452637001435 Family description; Region: VCBS; pfam13517 452637001436 Family description; Region: VCBS; pfam13517 452637001437 Family description; Region: VCBS; pfam13517 452637001438 Family description; Region: VCBS; pfam13517 452637001439 Family description; Region: VCBS; pfam13517 452637001440 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637001441 Family description; Region: VCBS; pfam13517 452637001442 Family description; Region: VCBS; pfam13517 452637001443 Family description; Region: VCBS; pfam13517 452637001444 Family description; Region: VCBS; pfam13517 452637001445 Family description; Region: VCBS; pfam13517 452637001446 Family description; Region: VCBS; pfam13517 452637001447 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637001448 Family description; Region: VCBS; pfam13517 452637001449 Family description; Region: VCBS; pfam13517 452637001450 Family description; Region: VCBS; pfam13517 452637001451 Family description; Region: VCBS; pfam13517 452637001452 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637001453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001454 binding surface 452637001455 TPR motif; other site 452637001456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001457 TPR motif; other site 452637001458 binding surface 452637001459 TPR repeat; Region: TPR_11; pfam13414 452637001460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001461 binding surface 452637001462 TPR motif; other site 452637001463 Family description; Region: VCBS; pfam13517 452637001464 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 452637001465 active site 452637001466 GH3 auxin-responsive promoter; Region: GH3; pfam03321 452637001467 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 452637001468 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 452637001469 catalytic residues [active] 452637001470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452637001471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452637001472 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 452637001473 dimerization interface [polypeptide binding]; other site 452637001474 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 452637001475 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 452637001476 catalytic residue [active] 452637001477 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 452637001478 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 452637001479 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 452637001480 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 452637001481 NAD(P) binding site [chemical binding]; other site 452637001482 shikimate binding site; other site 452637001483 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 452637001484 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 452637001485 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 452637001486 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 452637001487 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 452637001488 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 452637001489 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 452637001490 IHF - DNA interface [nucleotide binding]; other site 452637001491 IHF dimer interface [polypeptide binding]; other site 452637001492 Protein of unknown function DUF91; Region: DUF91; cl00709 452637001493 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 452637001494 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 452637001495 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 452637001496 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 452637001497 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 452637001498 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 452637001499 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 452637001500 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 452637001501 HlyD family secretion protein; Region: HlyD_3; pfam13437 452637001502 Outer membrane efflux protein; Region: OEP; pfam02321 452637001503 Outer membrane efflux protein; Region: OEP; pfam02321 452637001504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452637001505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452637001506 malate dehydrogenase; Provisional; Region: PRK05442 452637001507 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 452637001508 NAD(P) binding site [chemical binding]; other site 452637001509 dimer interface [polypeptide binding]; other site 452637001510 malate binding site [chemical binding]; other site 452637001511 muropeptide transporter; Reviewed; Region: ampG; PRK11902 452637001512 muropeptide transporter; Validated; Region: ampG; cl17669 452637001513 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 452637001514 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 452637001515 Family description; Region: VCBS; pfam13517 452637001516 Family description; Region: VCBS; pfam13517 452637001517 Family description; Region: VCBS; pfam13517 452637001518 Family description; Region: VCBS; pfam13517 452637001519 Family description; Region: VCBS; pfam13517 452637001520 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637001521 Family description; Region: VCBS; pfam13517 452637001522 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637001523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001524 TPR motif; other site 452637001525 TPR repeat; Region: TPR_11; pfam13414 452637001526 binding surface 452637001527 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637001528 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452637001529 DNA binding site [nucleotide binding] 452637001530 domain linker motif; other site 452637001531 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452637001532 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637001533 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452637001534 DNA binding site [nucleotide binding] 452637001535 domain linker motif; other site 452637001536 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452637001537 Periplasmic binding protein-like domain; Region: Peripla_BP_3; pfam13377 452637001538 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 452637001539 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637001540 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 452637001541 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 452637001542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 452637001543 TPR motif; other site 452637001544 binding surface 452637001545 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 452637001546 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452637001547 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 452637001548 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452637001549 non-specific DNA binding site [nucleotide binding]; other site 452637001550 salt bridge; other site 452637001551 sequence-specific DNA binding site [nucleotide binding]; other site 452637001552 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 452637001553 TIR domain; Region: TIR_2; pfam13676 452637001554 TIGR02679 family protein; Region: TIGR02679 452637001555 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 452637001556 TIGR02680 family protein; Region: TIGR02680 452637001557 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 452637001558 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 452637001559 TIGR02677 family protein; Region: TIGR02677 452637001560 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 452637001561 TniQ; Region: TniQ; pfam06527 452637001562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 452637001563 AAA domain; Region: AAA_22; pfam13401 452637001564 Walker A motif; other site 452637001565 ATP binding site [chemical binding]; other site 452637001566 Integrase core domain; Region: rve; pfam00665 452637001567 TniQ; Region: TniQ; pfam06527 452637001568 HNH endonuclease; Region: HNH; pfam01844 452637001569 active site 452637001570 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 452637001571 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 452637001572 substrate binding site [chemical binding]; other site 452637001573 ATP binding site [chemical binding]; other site 452637001574 Predicted regulatory domain of prephenate dehydrogenase [Translation, ribosomal structure and biogenesis]; Region: COG4937 452637001575 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 452637001576 Restriction endonuclease; Region: Mrr_cat; pfam04471 452637001577 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 452637001578 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 452637001579 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 452637001580 Beta-Casp domain; Region: Beta-Casp; smart01027 452637001581 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 452637001582 NHL repeat; Region: NHL; pfam01436 452637001583 NHL repeat; Region: NHL; pfam01436 452637001584 Immunoglobulin domain; Region: Ig; cd00096 452637001585 Immunoglobulin like; Region: IG_like; smart00410 452637001586 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 452637001587 PLD-like domain; Region: PLDc_2; pfam13091 452637001588 putative active site [active] 452637001589 catalytic site [active] 452637001590 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 452637001591 PLD-like domain; Region: PLDc_2; pfam13091 452637001592 putative active site [active] 452637001593 catalytic site [active] 452637001594 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 452637001595 active site 452637001596 putative substrate binding region [chemical binding]; other site 452637001597 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 452637001598 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 452637001599 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 452637001600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637001601 S-adenosylmethionine binding site [chemical binding]; other site 452637001602 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 452637001603 catalytic core [active] 452637001604 Kelch motif; Region: Kelch_6; pfam13964 452637001605 Kelch motif; Region: Kelch_1; pfam01344 452637001606 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 452637001607 Kelch motif; Region: Kelch_1; pfam01344 452637001608 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 452637001609 YceI-like domain; Region: YceI; pfam04264 452637001610 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 452637001611 substrate binding pocket [chemical binding]; other site 452637001612 substrate-Mg2+ binding site; other site 452637001613 aspartate-rich region 1; other site 452637001614 aspartate-rich region 2; other site 452637001615 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637001616 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 452637001617 FtsX-like permease family; Region: FtsX; pfam02687 452637001618 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452637001619 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452637001620 Walker A/P-loop; other site 452637001621 ATP binding site [chemical binding]; other site 452637001622 Q-loop/lid; other site 452637001623 ABC transporter signature motif; other site 452637001624 Walker B; other site 452637001625 D-loop; other site 452637001626 H-loop/switch region; other site 452637001627 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 452637001628 putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486 452637001629 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 452637001630 Cytochrome c; Region: Cytochrom_C; pfam00034 452637001631 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 452637001632 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 452637001633 P-loop; other site 452637001634 Magnesium ion binding site [ion binding]; other site 452637001635 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 452637001636 Magnesium ion binding site [ion binding]; other site 452637001637 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 452637001638 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 452637001639 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 452637001640 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637001641 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637001642 DNA binding residues [nucleotide binding] 452637001643 Putative zinc-finger; Region: zf-HC2; pfam13490 452637001644 HEAT repeats; Region: HEAT_2; pfam13646 452637001645 Double zinc ribbon; Region: DZR; pfam12773 452637001646 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 452637001647 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 452637001648 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 452637001649 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 452637001650 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 452637001651 active site 452637001652 metal binding site [ion binding]; metal-binding site 452637001653 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 452637001654 Family description; Region: VCBS; pfam13517 452637001655 Family description; Region: VCBS; pfam13517 452637001656 Family description; Region: VCBS; pfam13517 452637001657 Family description; Region: VCBS; pfam13517 452637001658 Family description; Region: VCBS; pfam13517 452637001659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001660 binding surface 452637001661 TPR motif; other site 452637001662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001663 binding surface 452637001664 Tetratricopeptide repeat; Region: TPR_16; pfam13432 452637001665 TPR motif; other site 452637001666 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 452637001667 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001668 binding surface 452637001669 TPR motif; other site 452637001670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001671 TPR motif; other site 452637001672 binding surface 452637001673 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 452637001674 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001675 binding surface 452637001676 TPR motif; other site 452637001677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001678 binding surface 452637001679 TPR motif; other site 452637001680 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001681 binding surface 452637001682 TPR motif; other site 452637001683 TPR repeat; Region: TPR_11; pfam13414 452637001684 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637001685 Family description; Region: VCBS; pfam13517 452637001686 Family description; Region: VCBS; pfam13517 452637001687 Family description; Region: VCBS; pfam13517 452637001688 Family description; Region: VCBS; pfam13517 452637001689 Family description; Region: VCBS; pfam13517 452637001690 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637001691 Family description; Region: VCBS; pfam13517 452637001692 Family description; Region: VCBS; pfam13517 452637001693 Family description; Region: VCBS; pfam13517 452637001694 Family description; Region: VCBS; pfam13517 452637001695 Family description; Region: VCBS; pfam13517 452637001696 TPR repeat; Region: TPR_11; pfam13414 452637001697 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001698 TPR motif; other site 452637001699 binding surface 452637001700 TPR repeat; Region: TPR_11; pfam13414 452637001701 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001702 TPR motif; other site 452637001703 TPR repeat; Region: TPR_11; pfam13414 452637001704 binding surface 452637001705 TPR repeat; Region: TPR_11; pfam13414 452637001706 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001707 binding surface 452637001708 TPR motif; other site 452637001709 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 452637001710 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 452637001711 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452637001712 FeS/SAM binding site; other site 452637001713 HemN C-terminal domain; Region: HemN_C; pfam06969 452637001714 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 452637001715 active site 452637001716 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 452637001717 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 452637001718 trimerization site [polypeptide binding]; other site 452637001719 active site 452637001720 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 452637001721 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 452637001722 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452637001723 catalytic residue [active] 452637001724 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 452637001725 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 452637001726 dimer interface [polypeptide binding]; other site 452637001727 PYR/PP interface [polypeptide binding]; other site 452637001728 TPP binding site [chemical binding]; other site 452637001729 substrate binding site [chemical binding]; other site 452637001730 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 452637001731 Domain of unknown function; Region: EKR; pfam10371 452637001732 4Fe-4S binding domain; Region: Fer4_6; pfam12837 452637001733 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 452637001734 TPP-binding site [chemical binding]; other site 452637001735 dimer interface [polypeptide binding]; other site 452637001736 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 452637001737 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 452637001738 phosphate binding site [ion binding]; other site 452637001739 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452637001740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637001741 active site 452637001742 phosphorylation site [posttranslational modification] 452637001743 intermolecular recognition site; other site 452637001744 dimerization interface [polypeptide binding]; other site 452637001745 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452637001746 DNA binding site [nucleotide binding] 452637001747 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452637001748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637001749 active site 452637001750 phosphorylation site [posttranslational modification] 452637001751 intermolecular recognition site; other site 452637001752 dimerization interface [polypeptide binding]; other site 452637001753 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452637001754 DNA binding site [nucleotide binding] 452637001755 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 452637001756 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 452637001757 dimer interface [polypeptide binding]; other site 452637001758 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 452637001759 putative CheW interface [polypeptide binding]; other site 452637001760 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 452637001761 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 452637001762 dimer interface [polypeptide binding]; other site 452637001763 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 452637001764 putative CheW interface [polypeptide binding]; other site 452637001765 Peptidase S46; Region: Peptidase_S46; pfam10459 452637001766 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 452637001767 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 452637001768 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 452637001769 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 452637001770 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 452637001771 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 452637001772 inhibitor-cofactor binding pocket; inhibition site 452637001773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637001774 catalytic residue [active] 452637001775 Bacterial PH domain; Region: DUF304; pfam03703 452637001776 Bacterial PH domain; Region: DUF304; pfam03703 452637001777 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 452637001778 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 452637001779 dimerization interface [polypeptide binding]; other site 452637001780 DPS ferroxidase diiron center [ion binding]; other site 452637001781 ion pore; other site 452637001782 hypothetical protein; Provisional; Region: PRK08912 452637001783 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452637001784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637001785 homodimer interface [polypeptide binding]; other site 452637001786 catalytic residue [active] 452637001787 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001788 binding surface 452637001789 TPR repeat; Region: TPR_11; pfam13414 452637001790 TPR motif; other site 452637001791 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 452637001792 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 452637001793 KpsF/GutQ family protein; Region: kpsF; TIGR00393 452637001794 putative active site [active] 452637001795 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 452637001796 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637001797 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637001798 fumarate hydratase; Provisional; Region: PRK15389 452637001799 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 452637001800 Fumarase C-terminus; Region: Fumerase_C; pfam05683 452637001801 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 452637001802 fumarate hydratase; Reviewed; Region: fumC; PRK00485 452637001803 Class II fumarases; Region: Fumarase_classII; cd01362 452637001804 active site 452637001805 tetramer interface [polypeptide binding]; other site 452637001806 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 452637001807 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637001808 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637001809 DNA binding residues [nucleotide binding] 452637001810 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 452637001811 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 452637001812 substrate binding pocket [chemical binding]; other site 452637001813 chain length determination region; other site 452637001814 substrate-Mg2+ binding site; other site 452637001815 catalytic residues [active] 452637001816 aspartate-rich region 1; other site 452637001817 active site lid residues [active] 452637001818 aspartate-rich region 2; other site 452637001819 CAAX protease self-immunity; Region: Abi; pfam02517 452637001820 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 452637001821 CARDB; Region: CARDB; pfam07705 452637001822 Secretin and TonB N terminus short domain; Region: STN; smart00965 452637001823 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 452637001824 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 452637001825 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 452637001826 Family description; Region: UvrD_C_2; pfam13538 452637001827 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 452637001828 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 452637001829 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637001830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637001831 active site 452637001832 phosphorylation site [posttranslational modification] 452637001833 intermolecular recognition site; other site 452637001834 dimerization interface [polypeptide binding]; other site 452637001835 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637001836 DNA binding residues [nucleotide binding] 452637001837 dimerization interface [polypeptide binding]; other site 452637001838 Secretin and TonB N terminus short domain; Region: STN; smart00965 452637001839 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 452637001840 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 452637001841 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637001842 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 452637001843 FecR protein; Region: FecR; pfam04773 452637001844 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452637001845 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637001846 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637001847 DNA binding residues [nucleotide binding] 452637001848 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 452637001849 Putative zinc ribbon domain; Region: DUF164; pfam02591 452637001850 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 452637001851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637001852 ATP binding site [chemical binding]; other site 452637001853 Mg2+ binding site [ion binding]; other site 452637001854 G-X-G motif; other site 452637001855 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 452637001856 anchoring element; other site 452637001857 dimer interface [polypeptide binding]; other site 452637001858 ATP binding site [chemical binding]; other site 452637001859 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 452637001860 active site 452637001861 putative metal-binding site [ion binding]; other site 452637001862 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 452637001863 DNA gyrase subunit A; Validated; Region: PRK05560 452637001864 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 452637001865 CAP-like domain; other site 452637001866 active site 452637001867 primary dimer interface [polypeptide binding]; other site 452637001868 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 452637001869 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 452637001870 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 452637001871 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 452637001872 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 452637001873 CAAX protease self-immunity; Region: Abi; pfam02517 452637001874 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 452637001875 CEO family (DUF1632); Region: DUF1632; pfam07857 452637001876 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 452637001877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637001878 S-adenosylmethionine binding site [chemical binding]; other site 452637001879 diaminopimelate decarboxylase; Region: lysA; TIGR01048 452637001880 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 452637001881 active site 452637001882 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 452637001883 substrate binding site [chemical binding]; other site 452637001884 catalytic residues [active] 452637001885 dimer interface [polypeptide binding]; other site 452637001886 Late embryogenesis abundant protein; Region: LEA_2; cl12118 452637001887 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 452637001888 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 452637001889 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 452637001890 L-aspartate oxidase; Provisional; Region: PRK06175 452637001891 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 452637001892 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 452637001893 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 452637001894 putative Iron-sulfur protein interface [polypeptide binding]; other site 452637001895 proximal heme binding site [chemical binding]; other site 452637001896 distal heme binding site [chemical binding]; other site 452637001897 putative dimer interface [polypeptide binding]; other site 452637001898 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452637001899 active site 452637001900 CoA binding site [chemical binding]; other site 452637001901 AMP binding site [chemical binding]; other site 452637001902 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 452637001903 dimer interface [polypeptide binding]; other site 452637001904 ADP-ribose binding site [chemical binding]; other site 452637001905 active site 452637001906 nudix motif; other site 452637001907 metal binding site [ion binding]; metal-binding site 452637001908 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 452637001909 short chain dehydrogenase; Provisional; Region: PRK06701 452637001910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452637001911 NAD(P) binding site [chemical binding]; other site 452637001912 active site 452637001913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637001914 binding surface 452637001915 TPR motif; other site 452637001916 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 452637001917 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 452637001918 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 452637001919 putative active site [active] 452637001920 putative substrate binding site [chemical binding]; other site 452637001921 putative cosubstrate binding site; other site 452637001922 catalytic site [active] 452637001923 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 452637001924 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 452637001925 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452637001926 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 452637001927 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 452637001928 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452637001929 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 452637001930 IMP binding site; other site 452637001931 dimer interface [polypeptide binding]; other site 452637001932 interdomain contacts; other site 452637001933 partial ornithine binding site; other site 452637001934 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 452637001935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637001936 active site 452637001937 phosphorylation site [posttranslational modification] 452637001938 intermolecular recognition site; other site 452637001939 dimerization interface [polypeptide binding]; other site 452637001940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637001941 Walker A motif; other site 452637001942 ATP binding site [chemical binding]; other site 452637001943 Walker B motif; other site 452637001944 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 452637001945 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 452637001946 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 452637001947 RNA methyltransferase, RsmE family; Region: TIGR00046 452637001948 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 452637001949 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 452637001950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637001951 S-adenosylmethionine binding site [chemical binding]; other site 452637001952 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 452637001953 Permease; Region: Permease; pfam02405 452637001954 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 452637001955 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 452637001956 Walker A/P-loop; other site 452637001957 ATP binding site [chemical binding]; other site 452637001958 Q-loop/lid; other site 452637001959 ABC transporter signature motif; other site 452637001960 Walker B; other site 452637001961 D-loop; other site 452637001962 H-loop/switch region; other site 452637001963 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 452637001964 mce related protein; Region: MCE; pfam02470 452637001965 argininosuccinate synthase; Provisional; Region: PRK13820 452637001966 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 452637001967 ANP binding site [chemical binding]; other site 452637001968 Substrate Binding Site II [chemical binding]; other site 452637001969 Substrate Binding Site I [chemical binding]; other site 452637001970 ornithine carbamoyltransferase; Provisional; Region: PRK00779 452637001971 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 452637001972 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 452637001973 acetylornithine aminotransferase; Provisional; Region: PRK02627 452637001974 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 452637001975 inhibitor-cofactor binding pocket; inhibition site 452637001976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637001977 catalytic residue [active] 452637001978 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 452637001979 nucleotide binding site [chemical binding]; other site 452637001980 substrate binding site [chemical binding]; other site 452637001981 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 452637001982 heterotetramer interface [polypeptide binding]; other site 452637001983 active site pocket [active] 452637001984 cleavage site 452637001985 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 452637001986 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 452637001987 dimer interface [polypeptide binding]; other site 452637001988 active site 452637001989 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 452637001990 catalytic residues [active] 452637001991 substrate binding site [chemical binding]; other site 452637001992 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 452637001993 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 452637001994 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 452637001995 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 452637001996 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 452637001997 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 452637001998 23S rRNA interface [nucleotide binding]; other site 452637001999 L3 interface [polypeptide binding]; other site 452637002000 Protein of unknown function (DUF423); Region: DUF423; pfam04241 452637002001 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 452637002002 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 452637002003 active site 452637002004 NTP binding site [chemical binding]; other site 452637002005 metal binding triad [ion binding]; metal-binding site 452637002006 transaldolase-like protein; Provisional; Region: PTZ00411 452637002007 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 452637002008 active site 452637002009 dimer interface [polypeptide binding]; other site 452637002010 catalytic residue [active] 452637002011 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 452637002012 putative active site [active] 452637002013 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 452637002014 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452637002015 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 452637002016 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 452637002017 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637002018 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 452637002019 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 452637002020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002021 active site 452637002022 phosphorylation site [posttranslational modification] 452637002023 intermolecular recognition site; other site 452637002024 dimerization interface [polypeptide binding]; other site 452637002025 LytTr DNA-binding domain; Region: LytTR; smart00850 452637002026 Histidine kinase; Region: His_kinase; pfam06580 452637002027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637002028 ATP binding site [chemical binding]; other site 452637002029 Mg2+ binding site [ion binding]; other site 452637002030 G-X-G motif; other site 452637002031 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 452637002032 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452637002033 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 452637002034 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 452637002035 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637002036 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 452637002037 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 452637002038 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 452637002039 XdhC Rossmann domain; Region: XdhC_C; pfam13478 452637002040 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 452637002041 Ligand binding site; other site 452637002042 metal-binding site 452637002043 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 452637002044 RDD family; Region: RDD; pfam06271 452637002045 HDOD domain; Region: HDOD; pfam08668 452637002046 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 452637002047 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637002048 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637002049 DNA binding residues [nucleotide binding] 452637002050 Proline dehydrogenase; Region: Pro_dh; cl03282 452637002051 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 452637002052 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 452637002053 Glutamate binding site [chemical binding]; other site 452637002054 homodimer interface [polypeptide binding]; other site 452637002055 NAD binding site [chemical binding]; other site 452637002056 catalytic residues [active] 452637002057 HDOD domain; Region: HDOD; pfam08668 452637002058 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 452637002059 active site 452637002060 substrate-binding site [chemical binding]; other site 452637002061 metal-binding site [ion binding] 452637002062 GTP binding site [chemical binding]; other site 452637002063 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 452637002064 Cation efflux family; Region: Cation_efflux; pfam01545 452637002065 ACT domain-containing protein [General function prediction only]; Region: COG4747 452637002066 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 452637002067 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 452637002068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637002069 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452637002070 putative substrate translocation pore; other site 452637002071 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637002072 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637002073 PAS domain; Region: PAS_9; pfam13426 452637002074 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 452637002075 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 452637002076 substrate binding pocket [chemical binding]; other site 452637002077 membrane-bound complex binding site; other site 452637002078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637002079 hinge residues; other site 452637002080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637002081 dimer interface [polypeptide binding]; other site 452637002082 phosphorylation site [posttranslational modification] 452637002083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637002084 ATP binding site [chemical binding]; other site 452637002085 Mg2+ binding site [ion binding]; other site 452637002086 G-X-G motif; other site 452637002087 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 452637002088 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 452637002089 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 452637002090 RNA binding surface [nucleotide binding]; other site 452637002091 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 452637002092 active site 452637002093 uracil binding [chemical binding]; other site 452637002094 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 452637002095 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 452637002096 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 452637002097 tetramer interface [polypeptide binding]; other site 452637002098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637002099 catalytic residue [active] 452637002100 GTPase RsgA; Reviewed; Region: PRK01889 452637002101 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 452637002102 GTPase/Zn-binding domain interface [polypeptide binding]; other site 452637002103 GTP/Mg2+ binding site [chemical binding]; other site 452637002104 G4 box; other site 452637002105 G5 box; other site 452637002106 G1 box; other site 452637002107 Switch I region; other site 452637002108 G2 box; other site 452637002109 G3 box; other site 452637002110 Switch II region; other site 452637002111 RDD family; Region: RDD; pfam06271 452637002112 Predicted membrane protein [Function unknown]; Region: COG2259 452637002113 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 452637002114 hypothetical protein; Provisional; Region: PRK05409 452637002115 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 452637002116 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 452637002117 NAD binding site [chemical binding]; other site 452637002118 ligand binding site [chemical binding]; other site 452637002119 catalytic site [active] 452637002120 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 452637002121 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 452637002122 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 452637002123 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 452637002124 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 452637002125 dimer interface [polypeptide binding]; other site 452637002126 PYR/PP interface [polypeptide binding]; other site 452637002127 TPP binding site [chemical binding]; other site 452637002128 substrate binding site [chemical binding]; other site 452637002129 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 452637002130 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 452637002131 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 452637002132 TPP-binding site [chemical binding]; other site 452637002133 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 452637002134 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 452637002135 NADH dehydrogenase subunit B; Validated; Region: PRK06411 452637002136 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 452637002137 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 452637002138 NADH dehydrogenase subunit D; Validated; Region: PRK06075 452637002139 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 452637002140 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 452637002141 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 452637002142 4Fe-4S binding domain; Region: Fer4; pfam00037 452637002143 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 452637002144 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 452637002145 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 452637002146 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 452637002147 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452637002148 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668 452637002149 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452637002150 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 452637002151 NADH-ubiquinone oxidoreductase chain 4, amino terminus; Region: Oxidored_q5_N; pfam01059 452637002152 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452637002153 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 452637002154 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452637002155 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 452637002156 Acyltransferase family; Region: Acyl_transf_3; pfam01757 452637002157 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 452637002158 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 452637002159 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 452637002160 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637002161 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637002162 FtsX-like permease family; Region: FtsX; pfam02687 452637002163 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637002164 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 452637002165 NADH(P)-binding; Region: NAD_binding_10; pfam13460 452637002166 NAD binding site [chemical binding]; other site 452637002167 putative active site [active] 452637002168 substrate binding site [chemical binding]; other site 452637002169 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 452637002170 DsrE/DsrF-like family; Region: DrsE; cl00672 452637002171 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452637002172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452637002173 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 452637002174 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452637002175 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637002176 homodimer interface [polypeptide binding]; other site 452637002177 catalytic residue [active] 452637002178 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452637002179 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 452637002180 active site 452637002181 metal binding site [ion binding]; metal-binding site 452637002182 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 452637002183 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 452637002184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637002185 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 452637002186 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 452637002187 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637002188 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 452637002189 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 452637002190 Isochorismatase family; Region: Isochorismatase; pfam00857 452637002191 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 452637002192 catalytic triad [active] 452637002193 conserved cis-peptide bond; other site 452637002194 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637002195 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637002196 dimer interface [polypeptide binding]; other site 452637002197 phosphorylation site [posttranslational modification] 452637002198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637002199 ATP binding site [chemical binding]; other site 452637002200 Mg2+ binding site [ion binding]; other site 452637002201 G-X-G motif; other site 452637002202 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637002203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637002204 dimer interface [polypeptide binding]; other site 452637002205 phosphorylation site [posttranslational modification] 452637002206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637002207 ATP binding site [chemical binding]; other site 452637002208 Mg2+ binding site [ion binding]; other site 452637002209 G-X-G motif; other site 452637002210 Response regulator receiver domain; Region: Response_reg; pfam00072 452637002211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002212 active site 452637002213 phosphorylation site [posttranslational modification] 452637002214 intermolecular recognition site; other site 452637002215 dimerization interface [polypeptide binding]; other site 452637002216 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637002217 PAS domain; Region: PAS_9; pfam13426 452637002218 putative active site [active] 452637002219 heme pocket [chemical binding]; other site 452637002220 PAS domain S-box; Region: sensory_box; TIGR00229 452637002221 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637002222 putative active site [active] 452637002223 heme pocket [chemical binding]; other site 452637002224 PAS domain S-box; Region: sensory_box; TIGR00229 452637002225 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637002226 putative active site [active] 452637002227 heme pocket [chemical binding]; other site 452637002228 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637002229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637002230 dimer interface [polypeptide binding]; other site 452637002231 phosphorylation site [posttranslational modification] 452637002232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637002233 ATP binding site [chemical binding]; other site 452637002234 Mg2+ binding site [ion binding]; other site 452637002235 G-X-G motif; other site 452637002236 Response regulator receiver domain; Region: Response_reg; pfam00072 452637002237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002238 active site 452637002239 phosphorylation site [posttranslational modification] 452637002240 intermolecular recognition site; other site 452637002241 dimerization interface [polypeptide binding]; other site 452637002242 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 452637002243 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637002244 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 452637002245 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 452637002246 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 452637002247 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637002248 putative active site [active] 452637002249 heme pocket [chemical binding]; other site 452637002250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637002251 dimer interface [polypeptide binding]; other site 452637002252 phosphorylation site [posttranslational modification] 452637002253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637002254 ATP binding site [chemical binding]; other site 452637002255 Mg2+ binding site [ion binding]; other site 452637002256 G-X-G motif; other site 452637002257 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637002258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002259 active site 452637002260 phosphorylation site [posttranslational modification] 452637002261 intermolecular recognition site; other site 452637002262 dimerization interface [polypeptide binding]; other site 452637002263 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 452637002264 oligomerization interface [polypeptide binding]; other site 452637002265 active site 452637002266 metal binding site [ion binding]; metal-binding site 452637002267 Pantoate-beta-alanine ligase; Region: PanC; cd00560 452637002268 pantoate--beta-alanine ligase; Region: panC; TIGR00018 452637002269 active site 452637002270 ATP-binding site [chemical binding]; other site 452637002271 pantoate-binding site; other site 452637002272 HXXH motif; other site 452637002273 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 452637002274 Flavoprotein; Region: Flavoprotein; pfam02441 452637002275 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 452637002276 Type III pantothenate kinase; Region: Pan_kinase; cl17198 452637002277 Quinolinate synthetase A protein; Region: NadA; pfam02445 452637002278 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 452637002279 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 452637002280 dimerization interface [polypeptide binding]; other site 452637002281 active site 452637002282 L-aspartate oxidase; Provisional; Region: PRK06175 452637002283 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 452637002284 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 452637002285 Beta/Gamma crystallin; Region: Crystall; cl02528 452637002286 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 452637002287 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 452637002288 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637002289 putative ADP-binding pocket [chemical binding]; other site 452637002290 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 452637002291 putative catalytic site [active] 452637002292 putative metal binding site [ion binding]; other site 452637002293 putative phosphate binding site [ion binding]; other site 452637002294 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 452637002295 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 452637002296 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 452637002297 catalytic site [active] 452637002298 G-X2-G-X-G-K; other site 452637002299 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 452637002300 four helix bundle protein; Region: TIGR02436 452637002301 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 452637002302 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 452637002303 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452637002304 FeS/SAM binding site; other site 452637002305 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 452637002306 N-acetyl-D-glucosamine binding site [chemical binding]; other site 452637002307 catalytic residue [active] 452637002308 rhombotail lipoprotein; Region: rhombo_lipo; TIGR04179 452637002309 rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902 452637002310 THAP domain; Region: THAP; cl02739 452637002311 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637002312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002313 active site 452637002314 phosphorylation site [posttranslational modification] 452637002315 intermolecular recognition site; other site 452637002316 dimerization interface [polypeptide binding]; other site 452637002317 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637002318 DNA binding residues [nucleotide binding] 452637002319 dimerization interface [polypeptide binding]; other site 452637002320 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 452637002321 heme-binding site [chemical binding]; other site 452637002322 PAS domain; Region: PAS_9; pfam13426 452637002323 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637002324 putative active site [active] 452637002325 heme pocket [chemical binding]; other site 452637002326 PAS domain S-box; Region: sensory_box; TIGR00229 452637002327 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637002328 putative active site [active] 452637002329 heme pocket [chemical binding]; other site 452637002330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637002331 dimer interface [polypeptide binding]; other site 452637002332 phosphorylation site [posttranslational modification] 452637002333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637002334 ATP binding site [chemical binding]; other site 452637002335 Mg2+ binding site [ion binding]; other site 452637002336 G-X-G motif; other site 452637002337 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637002338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002339 active site 452637002340 phosphorylation site [posttranslational modification] 452637002341 intermolecular recognition site; other site 452637002342 dimerization interface [polypeptide binding]; other site 452637002343 Response regulator receiver domain; Region: Response_reg; pfam00072 452637002344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002345 active site 452637002346 phosphorylation site [posttranslational modification] 452637002347 intermolecular recognition site; other site 452637002348 dimerization interface [polypeptide binding]; other site 452637002349 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637002350 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637002351 dimer interface [polypeptide binding]; other site 452637002352 phosphorylation site [posttranslational modification] 452637002353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637002354 ATP binding site [chemical binding]; other site 452637002355 Mg2+ binding site [ion binding]; other site 452637002356 G-X-G motif; other site 452637002357 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 452637002358 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 452637002359 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 452637002360 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 452637002361 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 452637002362 dimer interface [polypeptide binding]; other site 452637002363 putative CheW interface [polypeptide binding]; other site 452637002364 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 452637002365 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 452637002366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637002367 catalytic residue [active] 452637002368 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 452637002369 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 452637002370 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 452637002371 glutamate dehydrogenase; Provisional; Region: PRK09414 452637002372 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 452637002373 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 452637002374 NAD(P) binding site [chemical binding]; other site 452637002375 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 452637002376 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 452637002377 Switch I region; other site 452637002378 G3 box; other site 452637002379 Switch II region; other site 452637002380 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 452637002381 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452637002382 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452637002383 active site 452637002384 catalytic tetrad [active] 452637002385 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637002386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 452637002387 active site 452637002388 phosphorylation site [posttranslational modification] 452637002389 intermolecular recognition site; other site 452637002390 dimerization interface [polypeptide binding]; other site 452637002391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637002392 dimer interface [polypeptide binding]; other site 452637002393 phosphorylation site [posttranslational modification] 452637002394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637002395 ATP binding site [chemical binding]; other site 452637002396 Mg2+ binding site [ion binding]; other site 452637002397 G-X-G motif; other site 452637002398 PAS domain S-box; Region: sensory_box; TIGR00229 452637002399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637002400 ATP binding site [chemical binding]; other site 452637002401 Mg2+ binding site [ion binding]; other site 452637002402 G-X-G motif; other site 452637002403 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 452637002404 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 452637002405 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 452637002406 BON domain; Region: BON; pfam04972 452637002407 BON domain; Region: BON; pfam04972 452637002408 BON domain; Region: BON; pfam04972 452637002409 Response regulator receiver domain; Region: Response_reg; pfam00072 452637002410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002411 active site 452637002412 phosphorylation site [posttranslational modification] 452637002413 intermolecular recognition site; other site 452637002414 dimerization interface [polypeptide binding]; other site 452637002415 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637002416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 452637002417 active site 452637002418 intermolecular recognition site; other site 452637002419 dimerization interface [polypeptide binding]; other site 452637002420 PAS fold; Region: PAS_3; pfam08447 452637002421 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637002422 putative active site [active] 452637002423 heme pocket [chemical binding]; other site 452637002424 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452637002425 Histidine kinase; Region: HisKA_3; pfam07730 452637002426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637002427 ATP binding site [chemical binding]; other site 452637002428 Mg2+ binding site [ion binding]; other site 452637002429 G-X-G motif; other site 452637002430 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637002431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002432 active site 452637002433 phosphorylation site [posttranslational modification] 452637002434 intermolecular recognition site; other site 452637002435 dimerization interface [polypeptide binding]; other site 452637002436 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637002437 DNA binding residues [nucleotide binding] 452637002438 dimerization interface [polypeptide binding]; other site 452637002439 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 452637002440 ATP-binding site [chemical binding]; other site 452637002441 Gluconate-6-phosphate binding site [chemical binding]; other site 452637002442 Shikimate kinase; Region: SKI; pfam01202 452637002443 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 452637002444 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 452637002445 active site 452637002446 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 452637002447 active site 452637002448 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 452637002449 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637002450 putative active site [active] 452637002451 heme pocket [chemical binding]; other site 452637002452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637002453 dimer interface [polypeptide binding]; other site 452637002454 phosphorylation site [posttranslational modification] 452637002455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637002456 ATP binding site [chemical binding]; other site 452637002457 Mg2+ binding site [ion binding]; other site 452637002458 G-X-G motif; other site 452637002459 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637002460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002461 active site 452637002462 phosphorylation site [posttranslational modification] 452637002463 intermolecular recognition site; other site 452637002464 dimerization interface [polypeptide binding]; other site 452637002465 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637002466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002467 active site 452637002468 phosphorylation site [posttranslational modification] 452637002469 intermolecular recognition site; other site 452637002470 dimerization interface [polypeptide binding]; other site 452637002471 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 452637002472 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452637002473 FeS/SAM binding site; other site 452637002474 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 452637002475 A new structural DNA glycosylase; Region: AlkD_like; cd06561 452637002476 active site 452637002477 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 452637002478 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 452637002479 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 452637002480 hypothetical protein; Provisional; Region: PRK02947 452637002481 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 452637002482 putative active site [active] 452637002483 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 452637002484 Protein of unknown function, DUF481; Region: DUF481; pfam04338 452637002485 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 452637002486 FAD binding domain; Region: FAD_binding_4; pfam01565 452637002487 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 452637002488 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 452637002489 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 452637002490 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 452637002491 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 452637002492 heme-binding residues [chemical binding]; other site 452637002493 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 452637002494 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 452637002495 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 452637002496 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 452637002497 metal binding site [ion binding]; metal-binding site 452637002498 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 452637002499 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 452637002500 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 452637002501 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637002502 PAS domain; Region: PAS_9; pfam13426 452637002503 putative active site [active] 452637002504 heme pocket [chemical binding]; other site 452637002505 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637002506 dimer interface [polypeptide binding]; other site 452637002507 phosphorylation site [posttranslational modification] 452637002508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637002509 ATP binding site [chemical binding]; other site 452637002510 Mg2+ binding site [ion binding]; other site 452637002511 G-X-G motif; other site 452637002512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002513 intermolecular recognition site; other site 452637002514 active site 452637002515 dimerization interface [polypeptide binding]; other site 452637002516 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 452637002517 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452637002518 NAD(P) binding site [chemical binding]; other site 452637002519 active site 452637002520 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 452637002521 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637002522 Immunoglobulin domain; Region: Ig_3; pfam13927 452637002523 Immunoglobulin I-set domain; Region: I-set; pfam07679 452637002524 Immunoglobulin domain; Region: Ig; cd00096 452637002525 Immunoglobulin domain; Region: Ig; cl11960 452637002526 Immunoglobulin domain; Region: Ig; cd00096 452637002527 Immunoglobulin like; Region: IG_like; smart00410 452637002528 Immunoglobulin domain; Region: Ig; cl11960 452637002529 Immunoglobulin I-set domain; Region: I-set; pfam07679 452637002530 Immunoglobulin I-set domain; Region: I-set; pfam07679 452637002531 Immunoglobulin domain; Region: Ig_2; pfam13895 452637002532 Immunoglobulin domain; Region: Ig; cd00096 452637002533 Immunoglobulin I-set domain; Region: I-set; pfam07679 452637002534 Immunoglobulin domain; Region: Ig; cd00096 452637002535 Immunoglobulin I-set domain; Region: I-set; pfam07679 452637002536 Immunoglobulin I-set domain; Region: I-set; pfam07679 452637002537 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 452637002538 TRAM domain; Region: TRAM; cl01282 452637002539 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 452637002540 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 452637002541 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 452637002542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452637002543 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 452637002544 NAD(P) binding site [chemical binding]; other site 452637002545 active site 452637002546 peptide synthase; Provisional; Region: PRK09274 452637002547 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 452637002548 acyl-activating enzyme (AAE) consensus motif; other site 452637002549 putative AMP binding site [chemical binding]; other site 452637002550 putative active site [active] 452637002551 putative CoA binding site [chemical binding]; other site 452637002552 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 452637002553 catalytic site [active] 452637002554 putative active site [active] 452637002555 putative substrate binding site [chemical binding]; other site 452637002556 HRDC domain; Region: HRDC; cl02578 452637002557 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 452637002558 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 452637002559 active site 452637002560 Zn binding site [ion binding]; other site 452637002561 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 452637002562 Ligand Binding Site [chemical binding]; other site 452637002563 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 452637002564 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452637002565 FeS/SAM binding site; other site 452637002566 Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617 452637002567 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452637002568 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 452637002569 4-alpha-glucanotransferase; Provisional; Region: PRK14508 452637002570 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 452637002571 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637002572 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637002573 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 452637002574 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 452637002575 Ca binding site [ion binding]; other site 452637002576 active site 452637002577 catalytic site [active] 452637002578 Cupin domain; Region: Cupin_2; cl17218 452637002579 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 452637002580 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637002581 trehalose synthase; Region: treS_nterm; TIGR02456 452637002582 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 452637002583 active site 452637002584 catalytic site [active] 452637002585 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 452637002586 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 452637002587 G1 box; other site 452637002588 GTP/Mg2+ binding site [chemical binding]; other site 452637002589 Switch I region; other site 452637002590 G2 box; other site 452637002591 G3 box; other site 452637002592 Switch II region; other site 452637002593 G4 box; other site 452637002594 G5 box; other site 452637002595 Nucleoside recognition; Region: Gate; pfam07670 452637002596 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 452637002597 Nucleoside recognition; Region: Gate; pfam07670 452637002598 FeoA domain; Region: FeoA; pfam04023 452637002599 FeoA domain; Region: FeoA; pfam04023 452637002600 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 452637002601 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 452637002602 gamma subunit interface [polypeptide binding]; other site 452637002603 epsilon subunit interface [polypeptide binding]; other site 452637002604 LBP interface [polypeptide binding]; other site 452637002605 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 452637002606 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 452637002607 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 452637002608 alpha subunit interaction interface [polypeptide binding]; other site 452637002609 Walker A motif; other site 452637002610 ATP binding site [chemical binding]; other site 452637002611 Walker B motif; other site 452637002612 inhibitor binding site; inhibition site 452637002613 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 452637002614 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 452637002615 core domain interface [polypeptide binding]; other site 452637002616 delta subunit interface [polypeptide binding]; other site 452637002617 epsilon subunit interface [polypeptide binding]; other site 452637002618 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 452637002619 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 452637002620 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452637002621 Walker A motif; other site 452637002622 ATP binding site [chemical binding]; other site 452637002623 Walker B motif; other site 452637002624 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 452637002625 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 452637002626 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 452637002627 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 452637002628 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 452637002629 Methyltransferase domain; Region: Methyltransf_31; pfam13847 452637002630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637002631 S-adenosylmethionine binding site [chemical binding]; other site 452637002632 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 452637002633 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 452637002634 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 452637002635 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 452637002636 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 452637002637 trmE is a tRNA modification GTPase; Region: trmE; cd04164 452637002638 G1 box; other site 452637002639 GTP/Mg2+ binding site [chemical binding]; other site 452637002640 Switch I region; other site 452637002641 G2 box; other site 452637002642 Switch II region; other site 452637002643 G3 box; other site 452637002644 G4 box; other site 452637002645 G5 box; other site 452637002646 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 452637002647 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 452637002648 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 452637002649 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 452637002650 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 452637002651 recombinase A; Provisional; Region: recA; PRK09354 452637002652 hexamer interface [polypeptide binding]; other site 452637002653 Walker A motif; other site 452637002654 ATP binding site [chemical binding]; other site 452637002655 Walker B motif; other site 452637002656 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 452637002657 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 452637002658 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 452637002659 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 452637002660 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 452637002661 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 452637002662 transmembrane helices; other site 452637002663 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637002664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637002665 ATP binding site [chemical binding]; other site 452637002666 Mg2+ binding site [ion binding]; other site 452637002667 G-X-G motif; other site 452637002668 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452637002669 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 452637002670 putative NAD(P) binding site [chemical binding]; other site 452637002671 active site 452637002672 putative substrate binding site [chemical binding]; other site 452637002673 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 452637002674 GSH binding site [chemical binding]; other site 452637002675 catalytic residues [active] 452637002676 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 452637002677 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 452637002678 active site 452637002679 dimer interface [polypeptide binding]; other site 452637002680 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 452637002681 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 452637002682 active site 452637002683 FMN binding site [chemical binding]; other site 452637002684 substrate binding site [chemical binding]; other site 452637002685 3Fe-4S cluster binding site [ion binding]; other site 452637002686 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 452637002687 domain interface; other site 452637002688 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 452637002689 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 452637002690 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 452637002691 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 452637002692 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 452637002693 DsbD alpha interface [polypeptide binding]; other site 452637002694 catalytic residues [active] 452637002695 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637002696 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637002697 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 452637002698 HDOD domain; Region: HDOD; pfam08668 452637002699 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 452637002700 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 452637002701 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 452637002702 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 452637002703 CPxP motif; other site 452637002704 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 452637002705 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 452637002706 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 452637002707 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 452637002708 ligand binding site [chemical binding]; other site 452637002709 flexible hinge region; other site 452637002710 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 452637002711 non-specific DNA interactions [nucleotide binding]; other site 452637002712 DNA binding site [nucleotide binding] 452637002713 sequence specific DNA binding site [nucleotide binding]; other site 452637002714 putative cAMP binding site [chemical binding]; other site 452637002715 EamA-like transporter family; Region: EamA; pfam00892 452637002716 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 452637002717 EamA-like transporter family; Region: EamA; pfam00892 452637002718 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 452637002719 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 452637002720 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637002721 putative active site [active] 452637002722 heme pocket [chemical binding]; other site 452637002723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637002724 dimer interface [polypeptide binding]; other site 452637002725 phosphorylation site [posttranslational modification] 452637002726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637002727 ATP binding site [chemical binding]; other site 452637002728 Mg2+ binding site [ion binding]; other site 452637002729 G-X-G motif; other site 452637002730 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637002731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002732 active site 452637002733 phosphorylation site [posttranslational modification] 452637002734 intermolecular recognition site; other site 452637002735 dimerization interface [polypeptide binding]; other site 452637002736 SWI complex, BAF60b domains; Region: SWIB; smart00151 452637002737 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452637002738 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 452637002739 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 452637002740 Walker A/P-loop; other site 452637002741 ATP binding site [chemical binding]; other site 452637002742 Q-loop/lid; other site 452637002743 ABC transporter signature motif; other site 452637002744 Walker B; other site 452637002745 D-loop; other site 452637002746 H-loop/switch region; other site 452637002747 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 452637002748 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452637002749 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637002750 Walker A/P-loop; other site 452637002751 ATP binding site [chemical binding]; other site 452637002752 Q-loop/lid; other site 452637002753 ABC transporter signature motif; other site 452637002754 Walker B; other site 452637002755 D-loop; other site 452637002756 H-loop/switch region; other site 452637002757 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 452637002758 MgtE intracellular N domain; Region: MgtE_N; pfam03448 452637002759 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 452637002760 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 452637002761 Divalent cation transporter; Region: MgtE; pfam01769 452637002762 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452637002763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452637002764 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 452637002765 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 452637002766 HlyD family secretion protein; Region: HlyD_3; pfam13437 452637002767 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 452637002768 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452637002769 Walker A/P-loop; other site 452637002770 ATP binding site [chemical binding]; other site 452637002771 Q-loop/lid; other site 452637002772 ABC transporter signature motif; other site 452637002773 Walker B; other site 452637002774 D-loop; other site 452637002775 H-loop/switch region; other site 452637002776 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 452637002777 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452637002778 Walker A/P-loop; other site 452637002779 ATP binding site [chemical binding]; other site 452637002780 Q-loop/lid; other site 452637002781 ABC transporter signature motif; other site 452637002782 Walker B; other site 452637002783 D-loop; other site 452637002784 H-loop/switch region; other site 452637002785 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 452637002786 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 452637002787 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 452637002788 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 452637002789 Outer membrane efflux protein; Region: OEP; pfam02321 452637002790 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 452637002791 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 452637002792 Mechanosensitive ion channel; Region: MS_channel; pfam00924 452637002793 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 452637002794 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 452637002795 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 452637002796 putative dimer interface [polypeptide binding]; other site 452637002797 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 452637002798 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 452637002799 putative dimer interface [polypeptide binding]; other site 452637002800 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 452637002801 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452637002802 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 452637002803 dimerization interface [polypeptide binding]; other site 452637002804 substrate binding pocket [chemical binding]; other site 452637002805 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248 452637002806 substrate binding site [chemical binding]; other site 452637002807 dimerization interface [polypeptide binding]; other site 452637002808 active site 452637002809 calcium binding site [ion binding]; other site 452637002810 multidrug efflux protein; Reviewed; Region: PRK09579 452637002811 Protein export membrane protein; Region: SecD_SecF; cl14618 452637002812 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 452637002813 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 452637002814 HlyD family secretion protein; Region: HlyD_3; pfam13437 452637002815 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 452637002816 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 452637002817 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452637002818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637002819 homodimer interface [polypeptide binding]; other site 452637002820 catalytic residue [active] 452637002821 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637002822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002823 active site 452637002824 phosphorylation site [posttranslational modification] 452637002825 intermolecular recognition site; other site 452637002826 dimerization interface [polypeptide binding]; other site 452637002827 PAS fold; Region: PAS; pfam00989 452637002828 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637002829 putative active site [active] 452637002830 heme pocket [chemical binding]; other site 452637002831 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637002832 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637002833 putative active site [active] 452637002834 heme pocket [chemical binding]; other site 452637002835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637002836 dimer interface [polypeptide binding]; other site 452637002837 phosphorylation site [posttranslational modification] 452637002838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637002839 ATP binding site [chemical binding]; other site 452637002840 Mg2+ binding site [ion binding]; other site 452637002841 G-X-G motif; other site 452637002842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002843 active site 452637002844 phosphorylation site [posttranslational modification] 452637002845 intermolecular recognition site; other site 452637002846 dimerization interface [polypeptide binding]; other site 452637002847 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637002848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002849 active site 452637002850 phosphorylation site [posttranslational modification] 452637002851 intermolecular recognition site; other site 452637002852 dimerization interface [polypeptide binding]; other site 452637002853 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 452637002854 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 452637002855 FMN binding site [chemical binding]; other site 452637002856 active site 452637002857 catalytic residues [active] 452637002858 substrate binding site [chemical binding]; other site 452637002859 MarC family integral membrane protein; Region: MarC; cl00919 452637002860 Predicted permeases [General function prediction only]; Region: RarD; COG2962 452637002861 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 452637002862 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cd09593 452637002863 ligand binding site [chemical binding]; other site 452637002864 active site 452637002865 helicase 45; Provisional; Region: PTZ00424 452637002866 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 452637002867 ATP binding site [chemical binding]; other site 452637002868 Mg++ binding site [ion binding]; other site 452637002869 motif III; other site 452637002870 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452637002871 nucleotide binding region [chemical binding]; other site 452637002872 ATP-binding site [chemical binding]; other site 452637002873 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 452637002874 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 452637002875 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637002876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002877 active site 452637002878 phosphorylation site [posttranslational modification] 452637002879 intermolecular recognition site; other site 452637002880 dimerization interface [polypeptide binding]; other site 452637002881 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637002882 PAS domain; Region: PAS_9; pfam13426 452637002883 putative active site [active] 452637002884 heme pocket [chemical binding]; other site 452637002885 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452637002886 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 452637002887 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637002888 putative active site [active] 452637002889 heme pocket [chemical binding]; other site 452637002890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637002891 dimer interface [polypeptide binding]; other site 452637002892 phosphorylation site [posttranslational modification] 452637002893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637002894 ATP binding site [chemical binding]; other site 452637002895 Mg2+ binding site [ion binding]; other site 452637002896 G-X-G motif; other site 452637002897 Response regulator receiver domain; Region: Response_reg; pfam00072 452637002898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002899 active site 452637002900 phosphorylation site [posttranslational modification] 452637002901 intermolecular recognition site; other site 452637002902 dimerization interface [polypeptide binding]; other site 452637002903 CHASE3 domain; Region: CHASE3; pfam05227 452637002904 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 452637002905 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637002906 putative active site [active] 452637002907 heme pocket [chemical binding]; other site 452637002908 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637002909 dimer interface [polypeptide binding]; other site 452637002910 phosphorylation site [posttranslational modification] 452637002911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637002912 ATP binding site [chemical binding]; other site 452637002913 Mg2+ binding site [ion binding]; other site 452637002914 G-X-G motif; other site 452637002915 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 452637002916 MoaE homodimer interface [polypeptide binding]; other site 452637002917 MoaD interaction [polypeptide binding]; other site 452637002918 active site residues [active] 452637002919 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 452637002920 MoaE interaction surface [polypeptide binding]; other site 452637002921 MoeB interaction surface [polypeptide binding]; other site 452637002922 thiocarboxylated glycine; other site 452637002923 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 452637002924 trimer interface [polypeptide binding]; other site 452637002925 dimer interface [polypeptide binding]; other site 452637002926 putative active site [active] 452637002927 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 452637002928 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 452637002929 dimer interface [polypeptide binding]; other site 452637002930 putative functional site; other site 452637002931 putative MPT binding site; other site 452637002932 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 452637002933 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452637002934 FeS/SAM binding site; other site 452637002935 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 452637002936 DNA polymerase III subunit beta; Provisional; Region: PRK14943 452637002937 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 452637002938 putative DNA binding surface [nucleotide binding]; other site 452637002939 dimer interface [polypeptide binding]; other site 452637002940 beta-clamp/clamp loader binding surface; other site 452637002941 beta-clamp/translesion DNA polymerase binding surface; other site 452637002942 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 452637002943 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 452637002944 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 452637002945 CHASE3 domain; Region: CHASE3; pfam05227 452637002946 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637002947 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637002948 dimer interface [polypeptide binding]; other site 452637002949 phosphorylation site [posttranslational modification] 452637002950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637002951 ATP binding site [chemical binding]; other site 452637002952 Mg2+ binding site [ion binding]; other site 452637002953 G-X-G motif; other site 452637002954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002955 Response regulator receiver domain; Region: Response_reg; pfam00072 452637002956 active site 452637002957 phosphorylation site [posttranslational modification] 452637002958 intermolecular recognition site; other site 452637002959 dimerization interface [polypeptide binding]; other site 452637002960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002961 active site 452637002962 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637002963 phosphorylation site [posttranslational modification] 452637002964 intermolecular recognition site; other site 452637002965 dimerization interface [polypeptide binding]; other site 452637002966 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637002967 dimer interface [polypeptide binding]; other site 452637002968 phosphorylation site [posttranslational modification] 452637002969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637002970 ATP binding site [chemical binding]; other site 452637002971 Mg2+ binding site [ion binding]; other site 452637002972 G-X-G motif; other site 452637002973 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 452637002974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637002975 active site 452637002976 phosphorylation site [posttranslational modification] 452637002977 intermolecular recognition site; other site 452637002978 dimerization interface [polypeptide binding]; other site 452637002979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637002980 Walker A motif; other site 452637002981 ATP binding site [chemical binding]; other site 452637002982 Walker B motif; other site 452637002983 arginine finger; other site 452637002984 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 452637002985 threonine dehydratase; Provisional; Region: PRK08198 452637002986 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 452637002987 tetramer interface [polypeptide binding]; other site 452637002988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637002989 catalytic residue [active] 452637002990 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 452637002991 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 452637002992 substrate binding site [chemical binding]; other site 452637002993 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 452637002994 amidase catalytic site [active] 452637002995 Zn binding residues [ion binding]; other site 452637002996 muropeptide transporter; Validated; Region: ampG; cl17669 452637002997 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637002998 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452637002999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637003000 ATP binding site [chemical binding]; other site 452637003001 Mg2+ binding site [ion binding]; other site 452637003002 G-X-G motif; other site 452637003003 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637003004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637003005 active site 452637003006 phosphorylation site [posttranslational modification] 452637003007 intermolecular recognition site; other site 452637003008 dimerization interface [polypeptide binding]; other site 452637003009 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452637003010 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452637003011 Haem-binding domain; Region: Haem_bd; pfam14376 452637003012 Domain of unknown function (DUF4202); Region: DUF4202; pfam13875 452637003013 pyruvate carboxylase; Reviewed; Region: PRK12999 452637003014 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 452637003015 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 452637003016 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 452637003017 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 452637003018 active site 452637003019 catalytic residues [active] 452637003020 metal binding site [ion binding]; metal-binding site 452637003021 homodimer binding site [polypeptide binding]; other site 452637003022 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 452637003023 carboxyltransferase (CT) interaction site; other site 452637003024 biotinylation site [posttranslational modification]; other site 452637003025 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 452637003026 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 452637003027 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 452637003028 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 452637003029 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 452637003030 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 452637003031 Histidine kinase; Region: His_kinase; pfam06580 452637003032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 452637003033 ATP binding site [chemical binding]; other site 452637003034 Mg2+ binding site [ion binding]; other site 452637003035 G-X-G motif; other site 452637003036 two-component response regulator; Provisional; Region: PRK14084 452637003037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637003038 active site 452637003039 phosphorylation site [posttranslational modification] 452637003040 intermolecular recognition site; other site 452637003041 dimerization interface [polypeptide binding]; other site 452637003042 LytTr DNA-binding domain; Region: LytTR; smart00850 452637003043 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 452637003044 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 452637003045 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 452637003046 phosphate binding site [ion binding]; other site 452637003047 Rhomboid family; Region: Rhomboid; pfam01694 452637003048 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 452637003049 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452637003050 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 452637003051 putative NAD(P) binding site [chemical binding]; other site 452637003052 active site 452637003053 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 452637003054 active site 452637003055 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 452637003056 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 452637003057 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 452637003058 Peptidase family M48; Region: Peptidase_M48; cl12018 452637003059 CHASE2 domain; Region: CHASE2; pfam05226 452637003060 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 452637003061 cyclase homology domain; Region: CHD; cd07302 452637003062 nucleotidyl binding site; other site 452637003063 metal binding site [ion binding]; metal-binding site 452637003064 dimer interface [polypeptide binding]; other site 452637003065 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 452637003066 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 452637003067 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 452637003068 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 452637003069 Fic family protein [Function unknown]; Region: COG3177 452637003070 Fic/DOC family; Region: Fic; pfam02661 452637003071 Methyltransferase domain; Region: Methyltransf_18; pfam12847 452637003072 EamA-like transporter family; Region: EamA; pfam00892 452637003073 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 452637003074 EamA-like transporter family; Region: EamA; pfam00892 452637003075 Response regulator receiver domain; Region: Response_reg; pfam00072 452637003076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637003077 active site 452637003078 phosphorylation site [posttranslational modification] 452637003079 intermolecular recognition site; other site 452637003080 dimerization interface [polypeptide binding]; other site 452637003081 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 452637003082 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452637003083 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 452637003084 anti sigma factor interaction site; other site 452637003085 regulatory phosphorylation site [posttranslational modification]; other site 452637003086 glycyl-tRNA synthetase; Provisional; Region: PRK04173 452637003087 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 452637003088 motif 1; other site 452637003089 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 452637003090 dimer interface [polypeptide binding]; other site 452637003091 active site 452637003092 motif 2; other site 452637003093 motif 3; other site 452637003094 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 452637003095 anticodon binding site; other site 452637003096 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 452637003097 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 452637003098 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 452637003099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 452637003100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637003101 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 452637003102 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 452637003103 A functionally uncharacterized subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the chitobiase of Serratia marcescens, a beta-N-1,4-acetylhexosaminidase that hydrolyzes the beta-1,4-glycosidic linkages in...; Region: GH20_chitobiase-like_1; cd06570 452637003104 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 452637003105 active site 452637003106 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 452637003107 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 452637003108 active site 452637003109 trimer interface [polypeptide binding]; other site 452637003110 allosteric site; other site 452637003111 active site lid [active] 452637003112 hexamer (dimer of trimers) interface [polypeptide binding]; other site 452637003113 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 452637003114 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 452637003115 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637003116 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 452637003117 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 452637003118 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 452637003119 Gram-negative bacterial tonB protein; Region: TonB; cl10048 452637003120 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 452637003121 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 452637003122 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 452637003123 Gram-negative bacterial tonB protein; Region: TonB; cl10048 452637003124 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 452637003125 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637003126 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 452637003127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452637003128 motif II; other site 452637003129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637003130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637003131 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 452637003132 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 452637003133 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 452637003134 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 452637003135 putative metal binding site [ion binding]; other site 452637003136 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 452637003137 Right handed beta helix region; Region: Beta_helix; pfam13229 452637003138 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637003139 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452637003140 DNA binding site [nucleotide binding] 452637003141 domain linker motif; other site 452637003142 Periplasmic binding protein-like domain; Region: Peripla_BP_3; pfam13377 452637003143 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 452637003144 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 452637003145 Multicopper oxidase; Region: Cu-oxidase; pfam00394 452637003146 transcription elongation factor GreA; Region: greA; TIGR01462 452637003147 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 452637003148 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 452637003149 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 452637003150 rRNA binding site [nucleotide binding]; other site 452637003151 predicted 30S ribosome binding site; other site 452637003152 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 452637003153 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452637003154 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452637003155 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 452637003156 PLD-like domain; Region: PLDc_2; pfam13091 452637003157 putative active site [active] 452637003158 catalytic site [active] 452637003159 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 452637003160 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 452637003161 active site 452637003162 Helix-turn-helix domain; Region: HTH_17; pfam12728 452637003163 TraB family; Region: TraB; pfam01963 452637003164 Helix-turn-helix domain; Region: HTH_17; pfam12728 452637003165 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452637003166 AAA domain; Region: AAA_22; pfam13401 452637003167 Walker A motif; other site 452637003168 Integrase core domain; Region: rve; pfam00665 452637003169 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452637003170 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452637003171 non-specific DNA binding site [nucleotide binding]; other site 452637003172 salt bridge; other site 452637003173 sequence-specific DNA binding site [nucleotide binding]; other site 452637003174 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 452637003175 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 452637003176 Catalytic site [active] 452637003177 NADH kinase; Region: PLN02929 452637003178 SPFH domain / Band 7 family; Region: Band_7; pfam01145 452637003179 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 452637003180 Isochorismatase family; Region: Isochorismatase; pfam00857 452637003181 catalytic triad [active] 452637003182 metal binding site [ion binding]; metal-binding site 452637003183 conserved cis-peptide bond; other site 452637003184 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 452637003185 nudix motif; other site 452637003186 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 452637003187 NAD+ synthase (glutamine-hydrolysing); Region: PLN02339 452637003188 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 452637003189 multimer interface [polypeptide binding]; other site 452637003190 active site 452637003191 catalytic triad [active] 452637003192 protein interface 1 [polypeptide binding]; other site 452637003193 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 452637003194 Ligand Binding Site [chemical binding]; other site 452637003195 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 452637003196 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 452637003197 active site 452637003198 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452637003199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452637003200 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 452637003201 dimerization interface [polypeptide binding]; other site 452637003202 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 452637003203 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 452637003204 active site 452637003205 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 452637003206 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637003207 DNA binding residues [nucleotide binding] 452637003208 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 452637003209 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 452637003210 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 452637003211 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 452637003212 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 452637003213 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 452637003214 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 452637003215 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 452637003216 putative active site [active] 452637003217 putative metal binding site [ion binding]; other site 452637003218 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 452637003219 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 452637003220 Uncharacterized conserved protein [Function unknown]; Region: COG1801 452637003221 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 452637003222 FAD dependent oxidoreductase; Region: DAO; pfam01266 452637003223 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 452637003224 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452637003225 DNA-binding site [nucleotide binding]; DNA binding site 452637003226 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452637003227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637003228 homodimer interface [polypeptide binding]; other site 452637003229 catalytic residue [active] 452637003230 Low molecular weight phosphatase family; Region: LMWPc; cl00105 452637003231 active site 452637003232 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 452637003233 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 452637003234 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 452637003235 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 452637003236 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 452637003237 putative dimer interface [polypeptide binding]; other site 452637003238 N-terminal domain interface [polypeptide binding]; other site 452637003239 putative substrate binding pocket (H-site) [chemical binding]; other site 452637003240 Hypothetical protein TTHB210, a sigma(E)-regulated gene product found in Thermus thermophilus, and similar proteins; Region: TTHB210-like; cd11669 452637003241 oligomer interface [polypeptide binding]; other site 452637003242 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 452637003243 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 452637003244 DNA-binding site [nucleotide binding]; DNA binding site 452637003245 RNA-binding motif; other site 452637003246 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 452637003247 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 452637003248 Uncharacterized conserved protein [Function unknown]; Region: COG4127 452637003249 Restriction endonuclease; Region: Mrr_cat; pfam04471 452637003250 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452637003251 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452637003252 non-specific DNA binding site [nucleotide binding]; other site 452637003253 salt bridge; other site 452637003254 sequence-specific DNA binding site [nucleotide binding]; other site 452637003255 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 452637003256 active site 452637003257 HsdM N-terminal domain; Region: HsdM_N; pfam12161 452637003258 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 452637003259 Methyltransferase domain; Region: Methyltransf_26; pfam13659 452637003260 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637003261 Q-loop/lid; other site 452637003262 ABC transporter signature motif; other site 452637003263 Walker B; other site 452637003264 D-loop; other site 452637003265 H-loop/switch region; other site 452637003266 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 452637003267 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 452637003268 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 452637003269 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 452637003270 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452637003271 ATP binding site [chemical binding]; other site 452637003272 putative Mg++ binding site [ion binding]; other site 452637003273 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 452637003274 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 452637003275 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 452637003276 substrate binding pocket [chemical binding]; other site 452637003277 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 452637003278 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 452637003279 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 452637003280 putative catalytic residues [active] 452637003281 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 452637003282 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 452637003283 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 452637003284 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 452637003285 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 452637003286 Ca binding site [ion binding]; other site 452637003287 carbohydrate binding site [chemical binding]; other site 452637003288 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452637003289 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 452637003290 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452637003291 Walker A motif; other site 452637003292 Walker A motif; other site 452637003293 ATP binding site [chemical binding]; other site 452637003294 Walker B motif; other site 452637003295 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452637003296 Walker A motif; other site 452637003297 ATP binding site [chemical binding]; other site 452637003298 Walker B motif; other site 452637003299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637003300 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637003301 dimer interface [polypeptide binding]; other site 452637003302 phosphorylation site [posttranslational modification] 452637003303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637003304 ATP binding site [chemical binding]; other site 452637003305 Mg2+ binding site [ion binding]; other site 452637003306 G-X-G motif; other site 452637003307 Response regulator receiver domain; Region: Response_reg; pfam00072 452637003308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637003309 active site 452637003310 phosphorylation site [posttranslational modification] 452637003311 intermolecular recognition site; other site 452637003312 dimerization interface [polypeptide binding]; other site 452637003313 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 452637003314 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 452637003315 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 452637003316 active site 452637003317 homodimer interface [polypeptide binding]; other site 452637003318 catalytic site [active] 452637003319 acceptor binding site [chemical binding]; other site 452637003320 trehalose synthase; Region: treS_nterm; TIGR02456 452637003321 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 452637003322 active site 452637003323 catalytic site [active] 452637003324 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 452637003325 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 452637003326 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 452637003327 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 452637003328 DNA binding residues [nucleotide binding] 452637003329 B12 binding domain; Region: B12-binding_2; pfam02607 452637003330 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 452637003331 B12 binding site [chemical binding]; other site 452637003332 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 452637003333 Fasciclin domain; Region: Fasciclin; pfam02469 452637003334 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 452637003335 putative hydrophobic ligand binding site [chemical binding]; other site 452637003336 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 452637003337 S15/NS1/EPRS_RNA-binding domain. This short domain consists of a helix-turn-helix structure, which can bind to several types of RNA. It is found in the ribosomal protein S15, the influenza A viral nonstructural protein (NSA) and in several eukaryotic...; Region: S15_NS1_EPRS_RNA-bind; cl00349 452637003338 Herpesvirus UL43 protein; Region: Herpes_UL43; cl17419 452637003339 Histidine kinase; Region: His_kinase; pfam06580 452637003340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637003341 active site 452637003342 phosphorylation site [posttranslational modification] 452637003343 intermolecular recognition site; other site 452637003344 LytTr DNA-binding domain; Region: LytTR; pfam04397 452637003345 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 452637003346 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 452637003347 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 452637003348 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 452637003349 Protein export membrane protein; Region: SecD_SecF; cl14618 452637003350 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 452637003351 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 452637003352 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 452637003353 HlyD family secretion protein; Region: HlyD_3; pfam13437 452637003354 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 452637003355 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637003356 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 452637003357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 452637003358 Putative glucoamylase; Region: Glycoamylase; pfam10091 452637003359 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637003360 PAS domain; Region: PAS_9; pfam13426 452637003361 putative active site [active] 452637003362 heme pocket [chemical binding]; other site 452637003363 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452637003364 GAF domain; Region: GAF; pfam01590 452637003365 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637003366 PAS domain; Region: PAS_9; pfam13426 452637003367 putative active site [active] 452637003368 heme pocket [chemical binding]; other site 452637003369 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637003370 histidine kinase; Provisional; Region: PRK13557 452637003371 putative active site [active] 452637003372 heme pocket [chemical binding]; other site 452637003373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637003374 dimer interface [polypeptide binding]; other site 452637003375 phosphorylation site [posttranslational modification] 452637003376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637003377 ATP binding site [chemical binding]; other site 452637003378 Mg2+ binding site [ion binding]; other site 452637003379 G-X-G motif; other site 452637003380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637003381 active site 452637003382 phosphorylation site [posttranslational modification] 452637003383 intermolecular recognition site; other site 452637003384 dimerization interface [polypeptide binding]; other site 452637003385 PRC-barrel domain; Region: PRC; pfam05239 452637003386 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 452637003387 BON domain; Region: BON; pfam04972 452637003388 PrcB C-terminal; Region: PrcB_C; pfam14343 452637003389 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 452637003390 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 452637003391 HSP70 interaction site [polypeptide binding]; other site 452637003392 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 452637003393 substrate binding site [polypeptide binding]; other site 452637003394 dimer interface [polypeptide binding]; other site 452637003395 Protein of unknown function (DUF2835); Region: DUF2835; pfam11197 452637003396 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 452637003397 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 452637003398 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 452637003399 Response regulator receiver domain; Region: Response_reg; pfam00072 452637003400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637003401 active site 452637003402 phosphorylation site [posttranslational modification] 452637003403 intermolecular recognition site; other site 452637003404 dimerization interface [polypeptide binding]; other site 452637003405 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 452637003406 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637003407 putative active site [active] 452637003408 heme pocket [chemical binding]; other site 452637003409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637003410 dimer interface [polypeptide binding]; other site 452637003411 phosphorylation site [posttranslational modification] 452637003412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637003413 ATP binding site [chemical binding]; other site 452637003414 Mg2+ binding site [ion binding]; other site 452637003415 G-X-G motif; other site 452637003416 Response regulator receiver domain; Region: Response_reg; pfam00072 452637003417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637003418 active site 452637003419 phosphorylation site [posttranslational modification] 452637003420 intermolecular recognition site; other site 452637003421 dimerization interface [polypeptide binding]; other site 452637003422 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452637003423 dimerization interface [polypeptide binding]; other site 452637003424 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 452637003425 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452637003426 dimerization interface [polypeptide binding]; other site 452637003427 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452637003428 dimerization interface [polypeptide binding]; other site 452637003429 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452637003430 dimerization interface [polypeptide binding]; other site 452637003431 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 452637003432 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452637003433 dimerization interface [polypeptide binding]; other site 452637003434 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452637003435 dimerization interface [polypeptide binding]; other site 452637003436 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452637003437 dimerization interface [polypeptide binding]; other site 452637003438 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452637003439 dimerization interface [polypeptide binding]; other site 452637003440 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452637003441 dimerization interface [polypeptide binding]; other site 452637003442 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452637003443 GAF domain; Region: GAF; pfam01590 452637003444 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637003445 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637003446 dimer interface [polypeptide binding]; other site 452637003447 phosphorylation site [posttranslational modification] 452637003448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637003449 ATP binding site [chemical binding]; other site 452637003450 Mg2+ binding site [ion binding]; other site 452637003451 G-X-G motif; other site 452637003452 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637003453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637003454 active site 452637003455 phosphorylation site [posttranslational modification] 452637003456 intermolecular recognition site; other site 452637003457 dimerization interface [polypeptide binding]; other site 452637003458 Response regulator receiver domain; Region: Response_reg; pfam00072 452637003459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637003460 active site 452637003461 phosphorylation site [posttranslational modification] 452637003462 intermolecular recognition site; other site 452637003463 dimerization interface [polypeptide binding]; other site 452637003464 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637003465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637003466 active site 452637003467 phosphorylation site [posttranslational modification] 452637003468 intermolecular recognition site; other site 452637003469 dimerization interface [polypeptide binding]; other site 452637003470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 452637003471 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 452637003472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 452637003473 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 452637003474 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 452637003475 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 452637003476 active site 452637003477 DNA binding site [nucleotide binding] 452637003478 Int/Topo IB signature motif; other site 452637003479 catalytic residues [active] 452637003480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452637003481 Coenzyme A binding pocket [chemical binding]; other site 452637003482 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 452637003483 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 452637003484 Walker A/P-loop; other site 452637003485 ATP binding site [chemical binding]; other site 452637003486 Q-loop/lid; other site 452637003487 ABC transporter signature motif; other site 452637003488 Walker B; other site 452637003489 D-loop; other site 452637003490 H-loop/switch region; other site 452637003491 TOBE domain; Region: TOBE; pfam03459 452637003492 TOBE domain; Region: TOBE_2; pfam08402 452637003493 Predicted membrane protein [Function unknown]; Region: COG2860 452637003494 UPF0126 domain; Region: UPF0126; pfam03458 452637003495 UPF0126 domain; Region: UPF0126; pfam03458 452637003496 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 452637003497 active site 452637003498 homotetramer interface [polypeptide binding]; other site 452637003499 homodimer interface [polypeptide binding]; other site 452637003500 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 452637003501 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637003502 catalytic residue [active] 452637003503 formiminoglutamate deiminase; Region: hutF; TIGR02022 452637003504 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 452637003505 active site 452637003506 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452637003507 active site 452637003508 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 452637003509 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 452637003510 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 452637003511 catalytic triad [active] 452637003512 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 452637003513 Paraquat-inducible protein A; Region: PqiA; pfam04403 452637003514 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637003515 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637003516 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637003517 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637003518 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637003519 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637003520 Domain of unknown function (DUF303); Region: DUF303; pfam03629 452637003521 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 452637003522 GIY-YIG motif/motif A; other site 452637003523 active site 452637003524 catalytic site [active] 452637003525 putative DNA binding site [nucleotide binding]; other site 452637003526 metal binding site [ion binding]; metal-binding site 452637003527 UvrB/uvrC motif; Region: UVR; pfam02151 452637003528 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 452637003529 competence damage-inducible protein A; Provisional; Region: PRK00549 452637003530 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 452637003531 putative MPT binding site; other site 452637003532 Competence-damaged protein; Region: CinA; pfam02464 452637003533 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 452637003534 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 452637003535 sugar efflux transporter; Region: 2A0120; TIGR00899 452637003536 Peptidase family M48; Region: Peptidase_M48; cl12018 452637003537 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 452637003538 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 452637003539 Predicted transcriptional regulators [Transcription]; Region: COG1733 452637003540 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 452637003541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637003542 S-adenosylmethionine binding site [chemical binding]; other site 452637003543 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 452637003544 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 452637003545 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 452637003546 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 452637003547 Right handed beta helix region; Region: Beta_helix; pfam13229 452637003548 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 452637003549 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 452637003550 NADP binding site [chemical binding]; other site 452637003551 dimer interface [polypeptide binding]; other site 452637003552 Predicted small secreted protein [Function unknown]; Region: COG5510 452637003553 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 452637003554 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 452637003555 ATP binding site [chemical binding]; other site 452637003556 active site 452637003557 substrate binding site [chemical binding]; other site 452637003558 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 452637003559 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 452637003560 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 452637003561 DNA methylase; Region: N6_N4_Mtase; cl17433 452637003562 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 452637003563 ATP-binding site [chemical binding]; other site 452637003564 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 452637003565 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637003566 phosphorylation site [posttranslational modification] 452637003567 dimer interface [polypeptide binding]; other site 452637003568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637003569 ATP binding site [chemical binding]; other site 452637003570 Mg2+ binding site [ion binding]; other site 452637003571 G-X-G motif; other site 452637003572 Uncharacterized conserved protein [Function unknown]; Region: COG1434 452637003573 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 452637003574 putative active site [active] 452637003575 Response regulator receiver domain; Region: Response_reg; pfam00072 452637003576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637003577 active site 452637003578 phosphorylation site [posttranslational modification] 452637003579 intermolecular recognition site; other site 452637003580 dimerization interface [polypeptide binding]; other site 452637003581 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452637003582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637003583 active site 452637003584 phosphorylation site [posttranslational modification] 452637003585 intermolecular recognition site; other site 452637003586 dimerization interface [polypeptide binding]; other site 452637003587 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 452637003588 DNA binding site [nucleotide binding] 452637003589 Amidinotransferase; Region: Amidinotransf; cl12043 452637003590 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 452637003591 homotrimer interaction site [polypeptide binding]; other site 452637003592 putative active site [active] 452637003593 AAA-like domain; Region: AAA_10; pfam12846 452637003594 TrwC relaxase; Region: TrwC; pfam08751 452637003595 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 452637003596 AAA domain; Region: AAA_30; pfam13604 452637003597 Family description; Region: UvrD_C_2; pfam13538 452637003598 AAA-like domain; Region: AAA_10; pfam12846 452637003599 AAA-like domain; Region: AAA_10; pfam12846 452637003600 conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193 452637003601 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 452637003602 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 452637003603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637003604 Walker A motif; other site 452637003605 ATP binding site [chemical binding]; other site 452637003606 Walker B motif; other site 452637003607 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 452637003608 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637003609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 452637003610 phosphorylation site [posttranslational modification] 452637003611 intermolecular recognition site; other site 452637003612 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637003613 DNA binding residues [nucleotide binding] 452637003614 dimerization interface [polypeptide binding]; other site 452637003615 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 452637003616 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 452637003617 putative heme binding pocket [chemical binding]; other site 452637003618 Domain of unknown function (DUF932); Region: DUF932; cl12129 452637003619 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 452637003620 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 452637003621 Int/Topo IB signature motif; other site 452637003622 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 452637003623 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 452637003624 active site 452637003625 DNA binding site [nucleotide binding] 452637003626 Int/Topo IB signature motif; other site 452637003627 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 452637003628 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 452637003629 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 452637003630 Int/Topo IB signature motif; other site 452637003631 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 452637003632 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 452637003633 DNA binding residues [nucleotide binding] 452637003634 dimer interface [polypeptide binding]; other site 452637003635 metal binding site [ion binding]; metal-binding site 452637003636 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 452637003637 metal-binding site [ion binding] 452637003638 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 452637003639 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 452637003640 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 452637003641 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 452637003642 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 452637003643 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 452637003644 ring oligomerisation interface [polypeptide binding]; other site 452637003645 ATP/Mg binding site [chemical binding]; other site 452637003646 stacking interactions; other site 452637003647 hinge regions; other site 452637003648 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452637003649 circadian clock protein KaiC; Reviewed; Region: PRK09302 452637003650 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452637003651 Walker A motif; other site 452637003652 Walker A motif; other site 452637003653 ATP binding site [chemical binding]; other site 452637003654 ATP binding site [chemical binding]; other site 452637003655 Walker B motif; other site 452637003656 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452637003657 Walker A motif; other site 452637003658 ATP binding site [chemical binding]; other site 452637003659 Walker B motif; other site 452637003660 PAS domain; Region: PAS_9; pfam13426 452637003661 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637003662 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637003663 dimer interface [polypeptide binding]; other site 452637003664 phosphorylation site [posttranslational modification] 452637003665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637003666 ATP binding site [chemical binding]; other site 452637003667 Mg2+ binding site [ion binding]; other site 452637003668 G-X-G motif; other site 452637003669 Response regulator receiver domain; Region: Response_reg; pfam00072 452637003670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637003671 active site 452637003672 phosphorylation site [posttranslational modification] 452637003673 intermolecular recognition site; other site 452637003674 dimerization interface [polypeptide binding]; other site 452637003675 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637003676 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 452637003677 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 452637003678 active site 452637003679 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452637003680 Histidine kinase; Region: HisKA_3; pfam07730 452637003681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637003682 ATP binding site [chemical binding]; other site 452637003683 Mg2+ binding site [ion binding]; other site 452637003684 G-X-G motif; other site 452637003685 Response regulator receiver domain; Region: Response_reg; pfam00072 452637003686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637003687 active site 452637003688 phosphorylation site [posttranslational modification] 452637003689 intermolecular recognition site; other site 452637003690 dimerization interface [polypeptide binding]; other site 452637003691 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637003692 DNA binding residues [nucleotide binding] 452637003693 Protein of unknown function (DUF3185); Region: DUF3185; pfam11381 452637003694 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 452637003695 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 452637003696 putative active site [active] 452637003697 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 452637003698 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 452637003699 active site 452637003700 catalytic residues [active] 452637003701 DNA binding site [nucleotide binding] 452637003702 Int/Topo IB signature motif; other site 452637003703 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452637003704 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 452637003705 dimer interface [polypeptide binding]; other site 452637003706 putative metal binding site [ion binding]; other site 452637003707 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 452637003708 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 452637003709 active site 452637003710 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 452637003711 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 452637003712 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 452637003713 transmembrane helices; other site 452637003714 Peptidase C10 family; Region: Peptidase_C10; pfam01640 452637003715 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 452637003716 Immunoglobulin domain; Region: Ig; cl11960 452637003717 GMP synthase, PP-ATPase domain/subunit [Nucleotide transport and metabolism]; Region: GuaA; COG0519 452637003718 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 452637003719 Ligand Binding Site [chemical binding]; other site 452637003720 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 452637003721 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 452637003722 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 452637003723 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 452637003724 active site 452637003725 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 452637003726 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 452637003727 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 452637003728 Ligand binding site; other site 452637003729 DXD motif; other site 452637003730 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637003731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637003732 ATP binding site [chemical binding]; other site 452637003733 Mg2+ binding site [ion binding]; other site 452637003734 G-X-G motif; other site 452637003735 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 452637003736 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 452637003737 active site 452637003738 Zn binding site [ion binding]; other site 452637003739 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637003740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637003741 active site 452637003742 phosphorylation site [posttranslational modification] 452637003743 intermolecular recognition site; other site 452637003744 dimerization interface [polypeptide binding]; other site 452637003745 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 452637003746 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452637003747 DNA binding site [nucleotide binding] 452637003748 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637003749 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452637003750 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637003751 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637003752 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637003753 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 452637003754 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 452637003755 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 452637003756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637003757 putative substrate translocation pore; other site 452637003758 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 452637003759 active site 452637003760 catalytic residues [active] 452637003761 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 452637003762 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 452637003763 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 452637003764 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 452637003765 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 452637003766 NADP binding site [chemical binding]; other site 452637003767 homodimer interface [polypeptide binding]; other site 452637003768 active site 452637003769 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 452637003770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637003771 POT family; Region: PTR2; cl17359 452637003772 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 452637003773 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 452637003774 Potassium binding sites [ion binding]; other site 452637003775 Cesium cation binding sites [ion binding]; other site 452637003776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637003777 phosphorylation site [posttranslational modification] 452637003778 dimer interface [polypeptide binding]; other site 452637003779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637003780 ATP binding site [chemical binding]; other site 452637003781 Mg2+ binding site [ion binding]; other site 452637003782 G-X-G motif; other site 452637003783 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 452637003784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637003785 active site 452637003786 phosphorylation site [posttranslational modification] 452637003787 intermolecular recognition site; other site 452637003788 dimerization interface [polypeptide binding]; other site 452637003789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637003790 Walker A motif; other site 452637003791 ATP binding site [chemical binding]; other site 452637003792 Walker B motif; other site 452637003793 arginine finger; other site 452637003794 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 452637003795 Putative zinc ribbon domain; Region: DUF164; pfam02591 452637003796 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 452637003797 active site 452637003798 phosphorylation site [posttranslational modification] 452637003799 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 452637003800 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452637003801 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452637003802 active site 452637003803 catalytic tetrad [active] 452637003804 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 452637003805 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 452637003806 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 452637003807 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637003808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637003809 active site 452637003810 phosphorylation site [posttranslational modification] 452637003811 intermolecular recognition site; other site 452637003812 dimerization interface [polypeptide binding]; other site 452637003813 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637003814 DNA binding residues [nucleotide binding] 452637003815 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 452637003816 generic binding surface II; other site 452637003817 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637003818 Histidine kinase; Region: HisKA_3; pfam07730 452637003819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637003820 ATP binding site [chemical binding]; other site 452637003821 Mg2+ binding site [ion binding]; other site 452637003822 G-X-G motif; other site 452637003823 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637003824 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637003825 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637003826 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 452637003827 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 452637003828 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 452637003829 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 452637003830 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 452637003831 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 452637003832 Propanediol utilisation protein PduL; Region: PduL; pfam06130 452637003833 Propanediol utilisation protein PduL; Region: PduL; pfam06130 452637003834 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 452637003835 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 452637003836 Hexamer interface [polypeptide binding]; other site 452637003837 Hexagonal pore residue; other site 452637003838 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 452637003839 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 452637003840 Hexamer interface [polypeptide binding]; other site 452637003841 Hexagonal pore residue; other site 452637003842 Acetokinase family; Region: Acetate_kinase; cl17229 452637003843 propionate/acetate kinase; Provisional; Region: PRK12379 452637003844 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 452637003845 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 452637003846 Hexamer interface [polypeptide binding]; other site 452637003847 Hexagonal pore residue; other site 452637003848 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 452637003849 Hexamer/Pentamer interface [polypeptide binding]; other site 452637003850 central pore; other site 452637003851 aldehyde dehydrogenase EutE; Provisional; Region: PRK15398 452637003852 NAD(P) binding site [chemical binding]; other site 452637003853 catalytic residues [active] 452637003854 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 452637003855 Hexamer/Pentamer interface [polypeptide binding]; other site 452637003856 central pore; other site 452637003857 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 452637003858 Hexamer/Pentamer interface [polypeptide binding]; other site 452637003859 central pore; other site 452637003860 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 452637003861 intersubunit interface [polypeptide binding]; other site 452637003862 active site 452637003863 Zn2+ binding site [ion binding]; other site 452637003864 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 452637003865 L-lactate dehydrogenase-like enzymes; Region: LDH_like; cd00300 452637003866 NAD(P) binding site [chemical binding]; other site 452637003867 dimer interface [polypeptide binding]; other site 452637003868 tetramer (dimer of dimers) interface [polypeptide binding]; other site 452637003869 substrate binding site [chemical binding]; other site 452637003870 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 452637003871 N- and C-terminal domain interface [polypeptide binding]; other site 452637003872 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 452637003873 active site 452637003874 putative catalytic site [active] 452637003875 metal binding site [ion binding]; metal-binding site 452637003876 ATP binding site [chemical binding]; other site 452637003877 carbohydrate binding site [chemical binding]; other site 452637003878 L-rhamnose isomerase; Provisional; Region: PRK01076 452637003879 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 452637003880 intersubunit interface [polypeptide binding]; other site 452637003881 active site 452637003882 Zn2+ binding site [ion binding]; other site 452637003883 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 452637003884 active site 452637003885 intersubunit interface [polypeptide binding]; other site 452637003886 Zn2+ binding site [ion binding]; other site 452637003887 short chain dehydrogenase; Validated; Region: PRK08324 452637003888 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 452637003889 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452637003890 NAD(P) binding site [chemical binding]; other site 452637003891 active site 452637003892 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452637003893 dimerization interface [polypeptide binding]; other site 452637003894 putative DNA binding site [nucleotide binding]; other site 452637003895 putative Zn2+ binding site [ion binding]; other site 452637003896 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 452637003897 putative hydrophobic ligand binding site [chemical binding]; other site 452637003898 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 452637003899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452637003900 Coenzyme A binding pocket [chemical binding]; other site 452637003901 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452637003902 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452637003903 dimerization interface [polypeptide binding]; other site 452637003904 putative DNA binding site [nucleotide binding]; other site 452637003905 putative Zn2+ binding site [ion binding]; other site 452637003906 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 452637003907 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 452637003908 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 452637003909 Uncharacterized conserved protein [Function unknown]; Region: COG2454 452637003910 hypothetical protein; Provisional; Region: PRK10621 452637003911 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 452637003912 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 452637003913 inner membrane protein; Provisional; Region: PRK11715 452637003914 sensory histidine kinase CreC; Provisional; Region: PRK11100 452637003915 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 452637003916 dimerization interface [polypeptide binding]; other site 452637003917 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637003918 dimer interface [polypeptide binding]; other site 452637003919 phosphorylation site [posttranslational modification] 452637003920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637003921 ATP binding site [chemical binding]; other site 452637003922 Mg2+ binding site [ion binding]; other site 452637003923 G-X-G motif; other site 452637003924 DNA-binding response regulator CreB; Provisional; Region: PRK11083 452637003925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637003926 active site 452637003927 phosphorylation site [posttranslational modification] 452637003928 intermolecular recognition site; other site 452637003929 dimerization interface [polypeptide binding]; other site 452637003930 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452637003931 DNA binding site [nucleotide binding] 452637003932 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 452637003933 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 452637003934 putative catalytic residue [active] 452637003935 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 452637003936 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452637003937 FeS/SAM binding site; other site 452637003938 hypothetical protein; Provisional; Region: PRK03881 452637003939 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 452637003940 AMMECR1; Region: AMMECR1; cl00911 452637003941 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 452637003942 active site 452637003943 dimerization interface [polypeptide binding]; other site 452637003944 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 452637003945 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452637003946 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 452637003947 active site 452637003948 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 452637003949 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 452637003950 Two component regulator propeller; Region: Reg_prop; pfam07494 452637003951 Two component regulator propeller; Region: Reg_prop; pfam07494 452637003952 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 452637003953 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 452637003954 Tropomyosin like; Region: Tropomyosin_1; pfam12718 452637003955 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 452637003956 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637003957 dimer interface [polypeptide binding]; other site 452637003958 phosphorylation site [posttranslational modification] 452637003959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637003960 ATP binding site [chemical binding]; other site 452637003961 Mg2+ binding site [ion binding]; other site 452637003962 G-X-G motif; other site 452637003963 Response regulator receiver domain; Region: Response_reg; pfam00072 452637003964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637003965 active site 452637003966 phosphorylation site [posttranslational modification] 452637003967 intermolecular recognition site; other site 452637003968 dimerization interface [polypeptide binding]; other site 452637003969 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 452637003970 active site 452637003971 catalytic triad [active] 452637003972 Domain of unknown function (DUF303); Region: DUF303; pfam03629 452637003973 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 452637003974 Domain of unknown function (DUF303); Region: DUF303; pfam03629 452637003975 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 452637003976 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 452637003977 FOG: PKD repeat [General function prediction only]; Region: COG3291 452637003978 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 452637003979 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452637003980 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637003981 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637003982 DNA binding residues [nucleotide binding] 452637003983 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 452637003984 metal binding site [ion binding]; metal-binding site 452637003985 active site 452637003986 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 452637003987 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 452637003988 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452637003989 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 452637003990 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 452637003991 Na binding site [ion binding]; other site 452637003992 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 452637003993 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452637003994 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637003995 binding surface 452637003996 TPR motif; other site 452637003997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637003998 binding surface 452637003999 TPR motif; other site 452637004000 TPR repeat; Region: TPR_11; pfam13414 452637004001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637004002 binding surface 452637004003 TPR motif; other site 452637004004 TPR repeat; Region: TPR_11; pfam13414 452637004005 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 452637004006 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637004007 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 452637004008 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637004009 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637004010 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 452637004011 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 452637004012 Na binding site [ion binding]; other site 452637004013 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 452637004014 active site 452637004015 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 452637004016 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 452637004017 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 452637004018 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 452637004019 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 452637004020 active site 452637004021 catalytic triad [active] 452637004022 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 452637004023 active site 452637004024 catalytic triad [active] 452637004025 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637004026 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452637004027 DNA binding site [nucleotide binding] 452637004028 domain linker motif; other site 452637004029 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 452637004030 dimerization interface [polypeptide binding]; other site 452637004031 ligand binding site [chemical binding]; other site 452637004032 Domain of unknown function (DUF718); Region: DUF718; cl01281 452637004033 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 452637004034 Peptidase C80 family; Region: Peptidase_C80; pfam11713 452637004035 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 452637004036 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 452637004037 Metal-binding active site; metal-binding site 452637004038 AP (apurinic/apyrimidinic) site pocket; other site 452637004039 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 452637004040 alpha-galactosidase; Region: PLN02808; cl17638 452637004041 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 452637004042 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 452637004043 active site 452637004044 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 452637004045 active site 452637004046 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 452637004047 RibD C-terminal domain; Region: RibD_C; cl17279 452637004048 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637004049 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637004050 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637004051 FtsX-like permease family; Region: FtsX; pfam02687 452637004052 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 452637004053 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 452637004054 protein binding site [polypeptide binding]; other site 452637004055 Cupin domain; Region: Cupin_2; cl17218 452637004056 Cupin domain; Region: Cupin_2; cl17218 452637004057 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 452637004058 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452637004059 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 452637004060 active site 452637004061 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 452637004062 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 452637004063 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 452637004064 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 452637004065 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 452637004066 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 452637004067 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 452637004068 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 452637004069 Predicted amidohydrolase [General function prediction only]; Region: COG0388 452637004070 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 452637004071 active site 452637004072 catalytic triad [active] 452637004073 dimer interface [polypeptide binding]; other site 452637004074 Putative addiction module component; Region: Unstab_antitox; pfam09720 452637004075 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 452637004076 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 452637004077 intersubunit interface [polypeptide binding]; other site 452637004078 active site 452637004079 Zn2+ binding site [ion binding]; other site 452637004080 L-arabinose isomerase; Provisional; Region: PRK02929 452637004081 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 452637004082 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 452637004083 trimer interface [polypeptide binding]; other site 452637004084 putative substrate binding site [chemical binding]; other site 452637004085 putative metal binding site [ion binding]; other site 452637004086 ribulokinase; Provisional; Region: PRK04123 452637004087 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 452637004088 N- and C-terminal domain interface [polypeptide binding]; other site 452637004089 active site 452637004090 MgATP binding site [chemical binding]; other site 452637004091 catalytic site [active] 452637004092 metal binding site [ion binding]; metal-binding site 452637004093 carbohydrate binding site [chemical binding]; other site 452637004094 homodimer interface [polypeptide binding]; other site 452637004095 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637004096 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452637004097 DNA binding site [nucleotide binding] 452637004098 domain linker motif; other site 452637004099 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 452637004100 ligand binding site [chemical binding]; other site 452637004101 dimerization interface [polypeptide binding]; other site 452637004102 Protein of unknown function DUF72; Region: DUF72; pfam01904 452637004103 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 452637004104 active site 452637004105 catalytic residues [active] 452637004106 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 452637004107 putative transporter; Provisional; Region: PRK10484 452637004108 Na binding site [ion binding]; other site 452637004109 ECF sigma factor; Region: Sigma70_ECF; pfam07638 452637004110 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 452637004111 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452637004112 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452637004113 active site 452637004114 ATP binding site [chemical binding]; other site 452637004115 substrate binding site [chemical binding]; other site 452637004116 activation loop (A-loop); other site 452637004117 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 452637004118 substrate binding site [chemical binding]; other site 452637004119 active site 452637004120 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 452637004121 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 452637004122 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 452637004123 active site 452637004124 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 452637004125 substrate binding site [chemical binding]; other site 452637004126 active site 452637004127 Immunoglobulin domain; Region: Ig; cl11960 452637004128 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 452637004129 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 452637004130 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 452637004131 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 452637004132 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 452637004133 Immunoglobulin I-set domain; Region: I-set; pfam07679 452637004134 Immunoglobulin domain; Region: Ig_2; pfam13895 452637004135 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 452637004136 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 452637004137 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 452637004138 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 452637004139 Immunoglobulin I-set domain; Region: I-set; pfam07679 452637004140 Immunoglobulin C-2 Type; Region: IGc2; smart00408 452637004141 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 452637004142 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 452637004143 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 452637004144 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 452637004145 Cysteine-rich domain; Region: CCG; pfam02754 452637004146 Cysteine-rich domain; Region: CCG; pfam02754 452637004147 carbon starvation protein A; Provisional; Region: PRK15015 452637004148 Carbon starvation protein CstA; Region: CstA; pfam02554 452637004149 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 452637004150 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637004151 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 452637004152 6-phosphofructokinase; Provisional; Region: PRK14072 452637004153 active site 452637004154 ADP/pyrophosphate binding site [chemical binding]; other site 452637004155 allosteric effector site; other site 452637004156 dimerization interface [polypeptide binding]; other site 452637004157 fructose-1,6-bisphosphate binding site; other site 452637004158 adenylosuccinate lyase; Region: purB; TIGR00928 452637004159 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 452637004160 tetramer interface [polypeptide binding]; other site 452637004161 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 452637004162 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 452637004163 Sulfatase; Region: Sulfatase; pfam00884 452637004164 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 452637004165 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452637004166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637004167 active site 452637004168 phosphorylation site [posttranslational modification] 452637004169 intermolecular recognition site; other site 452637004170 dimerization interface [polypeptide binding]; other site 452637004171 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452637004172 DNA binding site [nucleotide binding] 452637004173 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452637004174 dimerization interface [polypeptide binding]; other site 452637004175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637004176 dimer interface [polypeptide binding]; other site 452637004177 phosphorylation site [posttranslational modification] 452637004178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637004179 ATP binding site [chemical binding]; other site 452637004180 Mg2+ binding site [ion binding]; other site 452637004181 G-X-G motif; other site 452637004182 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 452637004183 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 452637004184 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 452637004185 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 452637004186 inhibitor-cofactor binding pocket; inhibition site 452637004187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637004188 catalytic residue [active] 452637004189 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 452637004190 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 452637004191 Ligand binding site; other site 452637004192 Putative Catalytic site; other site 452637004193 DXD motif; other site 452637004194 putative formyltransferase; Provisional; Region: PRK06988 452637004195 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 452637004196 substrate binding site [chemical binding]; other site 452637004197 cosubstrate binding site; other site 452637004198 catalytic site [active] 452637004199 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 452637004200 active site 452637004201 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 452637004202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452637004203 NAD(P) binding site [chemical binding]; other site 452637004204 active site 452637004205 Putative addiction module component; Region: Unstab_antitox; cl09921 452637004206 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 452637004207 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 452637004208 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 452637004209 putative active site [active] 452637004210 putative catalytic site [active] 452637004211 putative Zn binding site [ion binding]; other site 452637004212 Predicted permeases [General function prediction only]; Region: COG0795 452637004213 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 452637004214 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 452637004215 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 452637004216 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452637004217 FeS/SAM binding site; other site 452637004218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637004219 putative substrate translocation pore; other site 452637004220 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 452637004221 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 452637004222 putative NAD(P) binding site [chemical binding]; other site 452637004223 catalytic Zn binding site [ion binding]; other site 452637004224 structural Zn binding site [ion binding]; other site 452637004225 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452637004226 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452637004227 active site 452637004228 catalytic tetrad [active] 452637004229 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 452637004230 Amidohydrolase; Region: Amidohydro_2; pfam04909 452637004231 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 452637004232 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 452637004233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637004234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637004235 TPR motif; other site 452637004236 TPR repeat; Region: TPR_11; pfam13414 452637004237 binding surface 452637004238 TPR repeat; Region: TPR_11; pfam13414 452637004239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637004240 binding surface 452637004241 TPR motif; other site 452637004242 Der1-like family; Region: DER1; cl17806 452637004243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637004244 S-adenosylmethionine binding site [chemical binding]; other site 452637004245 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637004246 binding surface 452637004247 TPR repeat; Region: TPR_11; pfam13414 452637004248 TPR motif; other site 452637004249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637004250 TPR motif; other site 452637004251 binding surface 452637004252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637004253 Walker A motif; other site 452637004254 ATP binding site [chemical binding]; other site 452637004255 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 452637004256 Walker B motif; other site 452637004257 arginine finger; other site 452637004258 Predicted permeases [General function prediction only]; Region: COG0701 452637004259 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 452637004260 active site residue [active] 452637004261 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 452637004262 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637004263 Domain of unknown function DUF302; Region: DUF302; cl01364 452637004264 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 452637004265 Uncharacterized protein domain (DUF2202); Region: DUF2202; pfam09968 452637004266 diiron binding motif [ion binding]; other site 452637004267 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 452637004268 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 452637004269 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 452637004270 30S subunit binding site; other site 452637004271 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 452637004272 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452637004273 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 452637004274 dimerization interface [polypeptide binding]; other site 452637004275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637004276 S-adenosylmethionine binding site [chemical binding]; other site 452637004277 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 452637004278 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 452637004279 active site 452637004280 metal binding site [ion binding]; metal-binding site 452637004281 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 452637004282 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 452637004283 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 452637004284 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 452637004285 catalytic residues [active] 452637004286 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 452637004287 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 452637004288 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 452637004289 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 452637004290 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 452637004291 GDP-Fucose binding site [chemical binding]; other site 452637004292 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 452637004293 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 452637004294 catalytic residues [active] 452637004295 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 452637004296 active site residue [active] 452637004297 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 452637004298 Protein export membrane protein; Region: SecD_SecF; cl14618 452637004299 Protein export membrane protein; Region: SecD_SecF; cl14618 452637004300 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 452637004301 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 452637004302 HlyD family secretion protein; Region: HlyD_3; pfam13437 452637004303 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 452637004304 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 452637004305 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452637004306 dimerization interface [polypeptide binding]; other site 452637004307 putative DNA binding site [nucleotide binding]; other site 452637004308 putative Zn2+ binding site [ion binding]; other site 452637004309 MOSC domain; Region: MOSC; pfam03473 452637004310 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 452637004311 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 452637004312 active site residue [active] 452637004313 putative inner membrane protein; Provisional; Region: PRK11099 452637004314 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 452637004315 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 452637004316 thiosulfate reductase PhsA; Provisional; Region: PRK15488 452637004317 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 452637004318 putative [Fe4-S4] binding site [ion binding]; other site 452637004319 putative molybdopterin cofactor binding site [chemical binding]; other site 452637004320 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 452637004321 putative molybdopterin cofactor binding site; other site 452637004322 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 452637004323 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452637004324 dimerization interface [polypeptide binding]; other site 452637004325 putative DNA binding site [nucleotide binding]; other site 452637004326 putative Zn2+ binding site [ion binding]; other site 452637004327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637004328 S-adenosylmethionine binding site [chemical binding]; other site 452637004329 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 452637004330 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 452637004331 hypothetical protein; Validated; Region: PRK00110 452637004332 membrane protein insertase; Provisional; Region: PRK01318 452637004333 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 452637004334 Haemolytic domain; Region: Haemolytic; pfam01809 452637004335 Ribonuclease P; Region: Ribonuclease_P; pfam00825 452637004336 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 452637004337 LysE type translocator; Region: LysE; cl00565 452637004338 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 452637004339 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 452637004340 active site 452637004341 metal binding site [ion binding]; metal-binding site 452637004342 homotetramer interface [polypeptide binding]; other site 452637004343 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 452637004344 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 452637004345 Protein of unknown function DUF45; Region: DUF45; pfam01863 452637004346 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 452637004347 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 452637004348 active site 452637004349 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637004350 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637004351 dimer interface [polypeptide binding]; other site 452637004352 phosphorylation site [posttranslational modification] 452637004353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637004354 ATP binding site [chemical binding]; other site 452637004355 Mg2+ binding site [ion binding]; other site 452637004356 G-X-G motif; other site 452637004357 Membrane transport protein; Region: Mem_trans; cl09117 452637004358 putative acetyltransferase; Provisional; Region: PRK03624 452637004359 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452637004360 Coenzyme A binding pocket [chemical binding]; other site 452637004361 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 452637004362 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 452637004363 glycerol kinase; Provisional; Region: glpK; PRK00047 452637004364 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 452637004365 N- and C-terminal domain interface [polypeptide binding]; other site 452637004366 active site 452637004367 MgATP binding site [chemical binding]; other site 452637004368 catalytic site [active] 452637004369 metal binding site [ion binding]; metal-binding site 452637004370 glycerol binding site [chemical binding]; other site 452637004371 homotetramer interface [polypeptide binding]; other site 452637004372 homodimer interface [polypeptide binding]; other site 452637004373 FBP binding site [chemical binding]; other site 452637004374 protein IIAGlc interface [polypeptide binding]; other site 452637004375 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 452637004376 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 452637004377 putative dimer interface [polypeptide binding]; other site 452637004378 multidrug efflux protein; Reviewed; Region: PRK01766 452637004379 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 452637004380 cation binding site [ion binding]; other site 452637004381 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 452637004382 methionine gamma-lyase; Validated; Region: PRK07049 452637004383 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452637004384 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452637004385 catalytic residue [active] 452637004386 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 452637004387 active site 452637004388 putative catalytic site [active] 452637004389 DNA binding site [nucleotide binding] 452637004390 putative phosphate binding site [ion binding]; other site 452637004391 metal binding site A [ion binding]; metal-binding site 452637004392 AP binding site [nucleotide binding]; other site 452637004393 metal binding site B [ion binding]; metal-binding site 452637004394 Competence-damaged protein; Region: CinA; pfam02464 452637004395 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 452637004396 putative amphipathic alpha helix; other site 452637004397 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 452637004398 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 452637004399 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452637004400 Walker A/P-loop; other site 452637004401 ATP binding site [chemical binding]; other site 452637004402 Q-loop/lid; other site 452637004403 ABC transporter signature motif; other site 452637004404 Walker B; other site 452637004405 D-loop; other site 452637004406 H-loop/switch region; other site 452637004407 flavoprotein, HI0933 family; Region: TIGR00275 452637004408 Predicted permeases [General function prediction only]; Region: COG0679 452637004409 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 452637004410 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 452637004411 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 452637004412 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 452637004413 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 452637004414 RNA binding site [nucleotide binding]; other site 452637004415 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 452637004416 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 452637004417 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 452637004418 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 452637004419 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637004420 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 452637004421 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637004422 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452637004423 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452637004424 Walker A/P-loop; other site 452637004425 ATP binding site [chemical binding]; other site 452637004426 Q-loop/lid; other site 452637004427 ABC transporter signature motif; other site 452637004428 Walker B; other site 452637004429 D-loop; other site 452637004430 H-loop/switch region; other site 452637004431 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 452637004432 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 452637004433 HlyD family secretion protein; Region: HlyD_3; pfam13437 452637004434 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 452637004435 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 452637004436 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 452637004437 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637004438 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637004439 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 452637004440 SnoaL-like domain; Region: SnoaL_3; pfam13474 452637004441 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452637004442 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452637004443 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637004444 Walker A/P-loop; other site 452637004445 ATP binding site [chemical binding]; other site 452637004446 Q-loop/lid; other site 452637004447 ABC transporter signature motif; other site 452637004448 Walker B; other site 452637004449 D-loop; other site 452637004450 H-loop/switch region; other site 452637004451 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 452637004452 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 452637004453 Catalytic site [active] 452637004454 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 452637004455 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 452637004456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637004457 putative substrate translocation pore; other site 452637004458 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 452637004459 intersubunit interface [polypeptide binding]; other site 452637004460 active site 452637004461 catalytic residue [active] 452637004462 Histidine kinase; Region: His_kinase; pfam06580 452637004463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637004464 ATP binding site [chemical binding]; other site 452637004465 Mg2+ binding site [ion binding]; other site 452637004466 G-X-G motif; other site 452637004467 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 452637004468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637004469 active site 452637004470 phosphorylation site [posttranslational modification] 452637004471 intermolecular recognition site; other site 452637004472 dimerization interface [polypeptide binding]; other site 452637004473 LytTr DNA-binding domain; Region: LytTR; smart00850 452637004474 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 452637004475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637004476 Walker A/P-loop; other site 452637004477 ATP binding site [chemical binding]; other site 452637004478 Q-loop/lid; other site 452637004479 ABC transporter signature motif; other site 452637004480 Walker B; other site 452637004481 D-loop; other site 452637004482 H-loop/switch region; other site 452637004483 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 452637004484 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 452637004485 PAS domain S-box; Region: sensory_box; TIGR00229 452637004486 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637004487 putative active site [active] 452637004488 heme pocket [chemical binding]; other site 452637004489 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637004490 dimer interface [polypeptide binding]; other site 452637004491 phosphorylation site [posttranslational modification] 452637004492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637004493 ATP binding site [chemical binding]; other site 452637004494 Mg2+ binding site [ion binding]; other site 452637004495 G-X-G motif; other site 452637004496 Response regulator receiver domain; Region: Response_reg; pfam00072 452637004497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637004498 active site 452637004499 phosphorylation site [posttranslational modification] 452637004500 intermolecular recognition site; other site 452637004501 dimerization interface [polypeptide binding]; other site 452637004502 phosphodiesterase; Provisional; Region: PRK12704 452637004503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452637004504 chromosome segregation protein; Provisional; Region: PRK02224 452637004505 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452637004506 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452637004507 active site 452637004508 catalytic tetrad [active] 452637004509 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 452637004510 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452637004511 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637004512 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637004513 DNA binding residues [nucleotide binding] 452637004514 EamA-like transporter family; Region: EamA; pfam00892 452637004515 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637004516 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 452637004517 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 452637004518 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 452637004519 catalytic loop [active] 452637004520 iron binding site [ion binding]; other site 452637004521 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 452637004522 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 452637004523 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 452637004524 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 452637004525 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 452637004526 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 452637004527 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 452637004528 SLBB domain; Region: SLBB; pfam10531 452637004529 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 452637004530 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 452637004531 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 452637004532 putative dimer interface [polypeptide binding]; other site 452637004533 [2Fe-2S] cluster binding site [ion binding]; other site 452637004534 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 452637004535 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 452637004536 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 452637004537 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637004538 putative active site [active] 452637004539 heme pocket [chemical binding]; other site 452637004540 Acetokinase family; Region: Acetate_kinase; cl17229 452637004541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637004542 ATP binding site [chemical binding]; other site 452637004543 Mg2+ binding site [ion binding]; other site 452637004544 G-X-G motif; other site 452637004545 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637004546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637004547 active site 452637004548 phosphorylation site [posttranslational modification] 452637004549 intermolecular recognition site; other site 452637004550 dimerization interface [polypeptide binding]; other site 452637004551 Response regulator receiver domain; Region: Response_reg; pfam00072 452637004552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637004553 active site 452637004554 phosphorylation site [posttranslational modification] 452637004555 intermolecular recognition site; other site 452637004556 dimerization interface [polypeptide binding]; other site 452637004557 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452637004558 Histidine kinase; Region: HisKA_3; pfam07730 452637004559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637004560 ATP binding site [chemical binding]; other site 452637004561 Mg2+ binding site [ion binding]; other site 452637004562 G-X-G motif; other site 452637004563 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637004564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637004565 active site 452637004566 phosphorylation site [posttranslational modification] 452637004567 intermolecular recognition site; other site 452637004568 dimerization interface [polypeptide binding]; other site 452637004569 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637004570 DNA binding residues [nucleotide binding] 452637004571 dimerization interface [polypeptide binding]; other site 452637004572 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 452637004573 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 452637004574 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 452637004575 HlyD family secretion protein; Region: HlyD_3; pfam13437 452637004576 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 452637004577 Outer membrane efflux protein; Region: OEP; pfam02321 452637004578 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 452637004579 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 452637004580 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637004581 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637004582 DNA binding residues [nucleotide binding] 452637004583 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 452637004584 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 452637004585 pyruvate kinase; Provisional; Region: PRK05826 452637004586 domain interfaces; other site 452637004587 active site 452637004588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637004589 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 452637004590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637004591 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 452637004592 putative hydrolase; Provisional; Region: PRK02113 452637004593 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452637004594 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452637004595 active site 452637004596 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 452637004597 active site 452637004598 putative GTP cyclohydrolase; Provisional; Region: PRK13674 452637004599 GxxExxY protein; Region: GxxExxY; TIGR04256 452637004600 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 452637004601 classical (c) SDRs; Region: SDR_c; cd05233 452637004602 NAD(P) binding site [chemical binding]; other site 452637004603 active site 452637004604 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 452637004605 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 452637004606 ABC transporter ATPase component; Reviewed; Region: PRK11147 452637004607 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452637004608 ABC transporter; Region: ABC_tran_2; pfam12848 452637004609 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452637004610 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 452637004611 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 452637004612 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452637004613 motif II; other site 452637004614 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 452637004615 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452637004616 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 452637004617 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 452637004618 oligomer interface [polypeptide binding]; other site 452637004619 metal binding site [ion binding]; metal-binding site 452637004620 metal binding site [ion binding]; metal-binding site 452637004621 putative Cl binding site [ion binding]; other site 452637004622 aspartate ring; other site 452637004623 basic sphincter; other site 452637004624 hydrophobic gate; other site 452637004625 periplasmic entrance; other site 452637004626 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 452637004627 active site 452637004628 phosphorylation site [posttranslational modification] 452637004629 hypothetical protein; Validated; Region: PRK06186 452637004630 conserved cys residue [active] 452637004631 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 452637004632 conserved cys residue [active] 452637004633 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 452637004634 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 452637004635 DNA-binding site [nucleotide binding]; DNA binding site 452637004636 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452637004637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637004638 homodimer interface [polypeptide binding]; other site 452637004639 catalytic residue [active] 452637004640 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 452637004641 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452637004642 Coenzyme A binding pocket [chemical binding]; other site 452637004643 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 452637004644 Transcriptional regulator; Region: Rrf2; pfam02082 452637004645 Rrf2 family protein; Region: rrf2_super; TIGR00738 452637004646 Transcriptional regulator; Region: Rrf2; cl17282 452637004647 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 452637004648 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 452637004649 ATP binding site [chemical binding]; other site 452637004650 Mg++ binding site [ion binding]; other site 452637004651 motif III; other site 452637004652 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452637004653 nucleotide binding region [chemical binding]; other site 452637004654 ATP-binding site [chemical binding]; other site 452637004655 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 452637004656 amphipathic channel; other site 452637004657 Asn-Pro-Ala signature motifs; other site 452637004658 Methyltransferase domain; Region: Methyltransf_31; pfam13847 452637004659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637004660 S-adenosylmethionine binding site [chemical binding]; other site 452637004661 putative acetyltransferase; Provisional; Region: PRK03624 452637004662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452637004663 Coenzyme A binding pocket [chemical binding]; other site 452637004664 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637004665 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 452637004666 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 452637004667 DNA binding residues [nucleotide binding] 452637004668 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 452637004669 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452637004670 motif II; other site 452637004671 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 452637004672 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452637004673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637004674 homodimer interface [polypeptide binding]; other site 452637004675 catalytic residue [active] 452637004676 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 452637004677 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 452637004678 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 452637004679 SLBB domain; Region: SLBB; pfam10531 452637004680 chain length determinant protein EpsF; Region: EpsF; TIGR03017 452637004681 Chain length determinant protein; Region: Wzz; cl15801 452637004682 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 452637004683 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 452637004684 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 452637004685 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 452637004686 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 452637004687 GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541 452637004688 GIY-YIG motif/motif A; other site 452637004689 active site 452637004690 catalytic site [active] 452637004691 metal binding site [ion binding]; metal-binding site 452637004692 GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541 452637004693 GIY-YIG motif/motif A; other site 452637004694 active site 452637004695 catalytic site [active] 452637004696 metal binding site [ion binding]; metal-binding site 452637004697 GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541 452637004698 GIY-YIG motif/motif A; other site 452637004699 active site 452637004700 catalytic site [active] 452637004701 metal binding site [ion binding]; metal-binding site 452637004702 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 452637004703 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 452637004704 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 452637004705 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 452637004706 ApbE family; Region: ApbE; pfam02424 452637004707 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 452637004708 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 452637004709 catalytic residues [active] 452637004710 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 452637004711 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452637004712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637004713 active site 452637004714 phosphorylation site [posttranslational modification] 452637004715 intermolecular recognition site; other site 452637004716 dimerization interface [polypeptide binding]; other site 452637004717 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452637004718 DNA binding site [nucleotide binding] 452637004719 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 452637004720 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 452637004721 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637004722 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637004723 dimer interface [polypeptide binding]; other site 452637004724 phosphorylation site [posttranslational modification] 452637004725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637004726 ATP binding site [chemical binding]; other site 452637004727 Mg2+ binding site [ion binding]; other site 452637004728 G-X-G motif; other site 452637004729 Immunoglobulin I-set domain; Region: I-set; pfam07679 452637004730 Immunoglobulin like; Region: IG_like; smart00410 452637004731 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 452637004732 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 452637004733 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 452637004734 GxxExxY protein; Region: GxxExxY; TIGR04256 452637004735 hypothetical protein; Provisional; Region: PRK10436 452637004736 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 452637004737 Walker A motif; other site 452637004738 ATP binding site [chemical binding]; other site 452637004739 Walker B motif; other site 452637004740 type II secretion system protein D; Region: type_II_gspD; TIGR02517 452637004741 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 452637004742 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 452637004743 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 452637004744 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 452637004745 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 452637004746 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 452637004747 Tetramer interface [polypeptide binding]; other site 452637004748 active site 452637004749 FMN-binding site [chemical binding]; other site 452637004750 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 452637004751 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 452637004752 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 452637004753 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 452637004754 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 452637004755 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637004756 Walker A/P-loop; other site 452637004757 ATP binding site [chemical binding]; other site 452637004758 Q-loop/lid; other site 452637004759 ABC transporter signature motif; other site 452637004760 Walker B; other site 452637004761 D-loop; other site 452637004762 H-loop/switch region; other site 452637004763 ABC transporter; Region: ABC_tran_2; pfam12848 452637004764 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 452637004765 EamA-like transporter family; Region: EamA; pfam00892 452637004766 Deoxyhypusine synthase; Region: DS; cl00826 452637004767 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 452637004768 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 452637004769 putative DNA binding site [nucleotide binding]; other site 452637004770 catalytic residue [active] 452637004771 putative H2TH interface [polypeptide binding]; other site 452637004772 putative catalytic residues [active] 452637004773 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 452637004774 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 452637004775 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 452637004776 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 452637004777 catalytic residues [active] 452637004778 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452637004779 non-specific DNA binding site [nucleotide binding]; other site 452637004780 salt bridge; other site 452637004781 sequence-specific DNA binding site [nucleotide binding]; other site 452637004782 Response regulator receiver domain; Region: Response_reg; pfam00072 452637004783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637004784 active site 452637004785 phosphorylation site [posttranslational modification] 452637004786 intermolecular recognition site; other site 452637004787 dimerization interface [polypeptide binding]; other site 452637004788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637004789 active site 452637004790 phosphorylation site [posttranslational modification] 452637004791 intermolecular recognition site; other site 452637004792 dimerization interface [polypeptide binding]; other site 452637004793 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 452637004794 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 452637004795 active site 452637004796 Zn binding site [ion binding]; other site 452637004797 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 452637004798 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 452637004799 HlyD family secretion protein; Region: HlyD_3; pfam13437 452637004800 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452637004801 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452637004802 Walker A/P-loop; other site 452637004803 ATP binding site [chemical binding]; other site 452637004804 Q-loop/lid; other site 452637004805 ABC transporter signature motif; other site 452637004806 Walker B; other site 452637004807 D-loop; other site 452637004808 H-loop/switch region; other site 452637004809 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637004810 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 452637004811 FtsX-like permease family; Region: FtsX; pfam02687 452637004812 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637004813 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 452637004814 FtsX-like permease family; Region: FtsX; pfam02687 452637004815 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 452637004816 four helix bundle protein; Region: TIGR02436 452637004817 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 452637004818 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 452637004819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637004820 active site 452637004821 phosphorylation site [posttranslational modification] 452637004822 intermolecular recognition site; other site 452637004823 dimerization interface [polypeptide binding]; other site 452637004824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637004825 Walker A motif; other site 452637004826 ATP binding site [chemical binding]; other site 452637004827 Walker B motif; other site 452637004828 arginine finger; other site 452637004829 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 452637004830 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452637004831 dimerization interface [polypeptide binding]; other site 452637004832 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 452637004833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637004834 dimer interface [polypeptide binding]; other site 452637004835 phosphorylation site [posttranslational modification] 452637004836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637004837 ATP binding site [chemical binding]; other site 452637004838 Mg2+ binding site [ion binding]; other site 452637004839 G-X-G motif; other site 452637004840 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 452637004841 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 452637004842 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 452637004843 Peptidase family U32; Region: Peptidase_U32; pfam01136 452637004844 Collagenase; Region: DUF3656; pfam12392 452637004845 Peptidase family U32; Region: Peptidase_U32; cl03113 452637004846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452637004847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452637004848 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 452637004849 dimerization interface [polypeptide binding]; other site 452637004850 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452637004851 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637004852 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637004853 DNA binding residues [nucleotide binding] 452637004854 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 452637004855 protein binding site [polypeptide binding]; other site 452637004856 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 452637004857 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 452637004858 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 452637004859 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 452637004860 Smr domain; Region: Smr; pfam01713 452637004861 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 452637004862 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 452637004863 active site 452637004864 catalytic residues [active] 452637004865 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 452637004866 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 452637004867 dimer interface [polypeptide binding]; other site 452637004868 active site residues [active] 452637004869 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 452637004870 hypothetical protein; Provisional; Region: PRK13665 452637004871 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452637004872 non-specific DNA binding site [nucleotide binding]; other site 452637004873 salt bridge; other site 452637004874 sequence-specific DNA binding site [nucleotide binding]; other site 452637004875 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 452637004876 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 452637004877 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 452637004878 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 452637004879 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 452637004880 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 452637004881 GrpE; Region: GrpE; pfam01025 452637004882 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 452637004883 dimer interface [polypeptide binding]; other site 452637004884 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 452637004885 chaperone protein DnaJ; Provisional; Region: PRK10767 452637004886 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 452637004887 HSP70 interaction site [polypeptide binding]; other site 452637004888 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 452637004889 Zn binding sites [ion binding]; other site 452637004890 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 452637004891 dimer interface [polypeptide binding]; other site 452637004892 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 452637004893 Na binding site [ion binding]; other site 452637004894 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 452637004895 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 452637004896 active site 452637004897 substrate binding site [chemical binding]; other site 452637004898 cosubstrate binding site; other site 452637004899 catalytic site [active] 452637004900 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 452637004901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637004902 S-adenosylmethionine binding site [chemical binding]; other site 452637004903 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 452637004904 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 452637004905 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 452637004906 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 452637004907 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 452637004908 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 452637004909 carboxyltransferase (CT) interaction site; other site 452637004910 biotinylation site [posttranslational modification]; other site 452637004911 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 452637004912 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 452637004913 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 452637004914 nucleotide binding region [chemical binding]; other site 452637004915 ATP-binding site [chemical binding]; other site 452637004916 SEC-C motif; Region: SEC-C; pfam02810 452637004917 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 452637004918 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 452637004919 putative active site [active] 452637004920 catalytic triad [active] 452637004921 putative dimer interface [polypeptide binding]; other site 452637004922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637004923 TPR motif; other site 452637004924 binding surface 452637004925 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637004926 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637004927 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637004928 FtsX-like permease family; Region: FtsX; pfam02687 452637004929 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637004930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637004931 active site 452637004932 phosphorylation site [posttranslational modification] 452637004933 intermolecular recognition site; other site 452637004934 dimerization interface [polypeptide binding]; other site 452637004935 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637004936 DNA binding residues [nucleotide binding] 452637004937 dimerization interface [polypeptide binding]; other site 452637004938 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452637004939 Histidine kinase; Region: HisKA_3; pfam07730 452637004940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637004941 ATP binding site [chemical binding]; other site 452637004942 Mg2+ binding site [ion binding]; other site 452637004943 G-X-G motif; other site 452637004944 short chain dehydrogenase; Provisional; Region: PRK06181 452637004945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452637004946 NAD(P) binding site [chemical binding]; other site 452637004947 active site 452637004948 Uncharacterized conserved protein [Function unknown]; Region: COG0432 452637004949 Haemolysin-III related; Region: HlyIII; cl03831 452637004950 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 452637004951 TspO/MBR family; Region: TspO_MBR; pfam03073 452637004952 hypothetical protein; Provisional; Region: PRK07338 452637004953 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 452637004954 metal binding site [ion binding]; metal-binding site 452637004955 dimer interface [polypeptide binding]; other site 452637004956 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452637004957 Beta-lactamase; Region: Beta-lactamase; pfam00144 452637004958 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 452637004959 Trp docking motif [polypeptide binding]; other site 452637004960 active site 452637004961 PQQ-like domain; Region: PQQ_2; pfam13360 452637004962 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 452637004963 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 452637004964 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 452637004965 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 452637004966 NAD(P) binding site [chemical binding]; other site 452637004967 catalytic residues [active] 452637004968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 452637004969 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 452637004970 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637004971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637004972 active site 452637004973 phosphorylation site [posttranslational modification] 452637004974 intermolecular recognition site; other site 452637004975 dimerization interface [polypeptide binding]; other site 452637004976 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637004977 DNA binding residues [nucleotide binding] 452637004978 dimerization interface [polypeptide binding]; other site 452637004979 Response regulator receiver domain; Region: Response_reg; pfam00072 452637004980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637004981 active site 452637004982 phosphorylation site [posttranslational modification] 452637004983 intermolecular recognition site; other site 452637004984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637004985 active site 452637004986 dimerization interface [polypeptide binding]; other site 452637004987 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452637004988 Histidine kinase; Region: HisKA_3; pfam07730 452637004989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637004990 ATP binding site [chemical binding]; other site 452637004991 Mg2+ binding site [ion binding]; other site 452637004992 G-X-G motif; other site 452637004993 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 452637004994 Catalytic site [active] 452637004995 HDOD domain; Region: HDOD; pfam08668 452637004996 recombination factor protein RarA; Reviewed; Region: PRK13342 452637004997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637004998 Walker A motif; other site 452637004999 ATP binding site [chemical binding]; other site 452637005000 Walker B motif; other site 452637005001 arginine finger; other site 452637005002 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 452637005003 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 452637005004 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 452637005005 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 452637005006 dimerization interface [polypeptide binding]; other site 452637005007 active site 452637005008 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 452637005009 homopentamer interface [polypeptide binding]; other site 452637005010 active site 452637005011 transcription antitermination factor NusB; Region: nusB; TIGR01951 452637005012 putative RNA binding site [nucleotide binding]; other site 452637005013 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 452637005014 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 452637005015 P loop; other site 452637005016 GTP binding site [chemical binding]; other site 452637005017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452637005018 dimer interface [polypeptide binding]; other site 452637005019 conserved gate region; other site 452637005020 putative PBP binding loops; other site 452637005021 ABC-ATPase subunit interface; other site 452637005022 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 452637005023 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 452637005024 FOG: WD40 repeat [General function prediction only]; Region: COG2319 452637005025 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 452637005026 structural tetrad; other site 452637005027 Cupin domain; Region: Cupin_2; pfam07883 452637005028 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637005029 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637005030 DNA binding residues [nucleotide binding] 452637005031 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637005032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637005033 ATP binding site [chemical binding]; other site 452637005034 Mg2+ binding site [ion binding]; other site 452637005035 G-X-G motif; other site 452637005036 SCP-2 sterol transfer family; Region: SCP2; cl01225 452637005037 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 452637005038 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637005039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637005040 dimer interface [polypeptide binding]; other site 452637005041 phosphorylation site [posttranslational modification] 452637005042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637005043 ATP binding site [chemical binding]; other site 452637005044 Mg2+ binding site [ion binding]; other site 452637005045 G-X-G motif; other site 452637005046 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637005047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637005048 active site 452637005049 phosphorylation site [posttranslational modification] 452637005050 intermolecular recognition site; other site 452637005051 dimerization interface [polypeptide binding]; other site 452637005052 Response regulator receiver domain; Region: Response_reg; pfam00072 452637005053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637005054 active site 452637005055 phosphorylation site [posttranslational modification] 452637005056 intermolecular recognition site; other site 452637005057 dimerization interface [polypeptide binding]; other site 452637005058 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637005059 DNA binding residues [nucleotide binding] 452637005060 Predicted membrane protein [Function unknown]; Region: COG2246 452637005061 GtrA-like protein; Region: GtrA; pfam04138 452637005062 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 452637005063 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637005064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 452637005065 DNA binding residues [nucleotide binding] 452637005066 dimerization interface [polypeptide binding]; other site 452637005067 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 452637005068 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 452637005069 P-loop, Walker A motif; other site 452637005070 Base recognition motif; other site 452637005071 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 452637005072 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 452637005073 Domain of unknown function DUF21; Region: DUF21; pfam01595 452637005074 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 452637005075 Transporter associated domain; Region: CorC_HlyC; smart01091 452637005076 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 452637005077 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 452637005078 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 452637005079 protein binding site [polypeptide binding]; other site 452637005080 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 452637005081 protein binding site [polypeptide binding]; other site 452637005082 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452637005083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637005084 active site 452637005085 phosphorylation site [posttranslational modification] 452637005086 intermolecular recognition site; other site 452637005087 dimerization interface [polypeptide binding]; other site 452637005088 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452637005089 DNA binding site [nucleotide binding] 452637005090 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 452637005091 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 452637005092 dimerization interface [polypeptide binding]; other site 452637005093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637005094 dimer interface [polypeptide binding]; other site 452637005095 phosphorylation site [posttranslational modification] 452637005096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637005097 ATP binding site [chemical binding]; other site 452637005098 Mg2+ binding site [ion binding]; other site 452637005099 G-X-G motif; other site 452637005100 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 452637005101 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 452637005102 Soluble P-type ATPase [General function prediction only]; Region: COG4087 452637005103 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 452637005104 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452637005105 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637005106 Sensory domain found in PocR; Region: PocR; pfam10114 452637005107 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 452637005108 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637005109 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 452637005110 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637005111 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452637005112 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452637005113 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 452637005114 dimerization interface [polypeptide binding]; other site 452637005115 NMT1-like family; Region: NMT1_2; pfam13379 452637005116 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 452637005117 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 452637005118 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 452637005119 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567 452637005120 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 452637005121 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 452637005122 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 452637005123 Flavodoxin; Region: Flavodoxin_1; pfam00258 452637005124 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 452637005125 FAD binding pocket [chemical binding]; other site 452637005126 FAD binding motif [chemical binding]; other site 452637005127 catalytic residues [active] 452637005128 NAD binding pocket [chemical binding]; other site 452637005129 phosphate binding motif [ion binding]; other site 452637005130 beta-alpha-beta structure motif; other site 452637005131 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 452637005132 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 452637005133 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 452637005134 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 452637005135 [4Fe-4S] binding site [ion binding]; other site 452637005136 molybdopterin cofactor binding site; other site 452637005137 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 452637005138 molybdopterin cofactor binding site; other site 452637005139 MOSC domain; Region: MOSC; pfam03473 452637005140 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 452637005141 GTP binding site; other site 452637005142 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 452637005143 putative transposase OrfB; Reviewed; Region: PHA02517 452637005144 DNA-binding interface [nucleotide binding]; DNA binding site 452637005145 Homeodomain-like domain; Region: HTH_32; pfam13565 452637005146 Integrase core domain; Region: rve; pfam00665 452637005147 Integrase core domain; Region: rve_3; cl15866 452637005148 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 452637005149 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 452637005150 catalytic domain interface [polypeptide binding]; other site 452637005151 putative homodimer interface [polypeptide binding]; other site 452637005152 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 452637005153 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 452637005154 catalytic domain interface [polypeptide binding]; other site 452637005155 homodimer interface [polypeptide binding]; other site 452637005156 putative active site [active] 452637005157 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 452637005158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637005159 dimer interface [polypeptide binding]; other site 452637005160 phosphorylation site [posttranslational modification] 452637005161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637005162 ATP binding site [chemical binding]; other site 452637005163 Mg2+ binding site [ion binding]; other site 452637005164 G-X-G motif; other site 452637005165 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637005166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637005167 active site 452637005168 phosphorylation site [posttranslational modification] 452637005169 intermolecular recognition site; other site 452637005170 dimerization interface [polypeptide binding]; other site 452637005171 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 452637005172 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 452637005173 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 452637005174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452637005175 dimer interface [polypeptide binding]; other site 452637005176 conserved gate region; other site 452637005177 putative PBP binding loops; other site 452637005178 ABC-ATPase subunit interface; other site 452637005179 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 452637005180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452637005181 dimer interface [polypeptide binding]; other site 452637005182 conserved gate region; other site 452637005183 putative PBP binding loops; other site 452637005184 ABC-ATPase subunit interface; other site 452637005185 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 452637005186 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 452637005187 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 452637005188 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452637005189 sugar binding site [chemical binding]; other site 452637005190 putative alpha-glucosidase; Provisional; Region: PRK10658 452637005191 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 452637005192 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 452637005193 active site 452637005194 homotrimer interface [polypeptide binding]; other site 452637005195 catalytic site [active] 452637005196 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 452637005197 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 452637005198 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 452637005199 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 452637005200 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637005201 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 452637005202 ligand binding site [chemical binding]; other site 452637005203 dimerization interface [polypeptide binding]; other site 452637005204 xylose isomerase; Provisional; Region: PRK05474 452637005205 xylose isomerase; Region: xylose_isom_A; TIGR02630 452637005206 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 452637005207 putative deacylase active site [active] 452637005208 Cupin domain; Region: Cupin_2; cl17218 452637005209 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 452637005210 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 452637005211 active site 452637005212 (T/H)XGH motif; other site 452637005213 Oligomerisation domain; Region: Oligomerisation; pfam02410 452637005214 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 452637005215 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 452637005216 O-Antigen ligase; Region: Wzy_C; pfam04932 452637005217 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 452637005218 Ligand binding site; other site 452637005219 Putative Catalytic site; other site 452637005220 DXD motif; other site 452637005221 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 452637005222 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 452637005223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 452637005224 putative methyltransferase, LIC12133 family; Region: MTase_LIC12133; TIGR04325 452637005225 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 452637005226 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 452637005227 metal-binding site 452637005228 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 452637005229 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 452637005230 Probable Catalytic site; other site 452637005231 metal-binding site 452637005232 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 452637005233 Bacterial sugar transferase; Region: Bac_transf; pfam02397 452637005234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637005235 binding surface 452637005236 TPR motif; other site 452637005237 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 452637005238 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 452637005239 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 452637005240 generic binding surface II; other site 452637005241 generic binding surface I; other site 452637005242 methionine sulfoxide reductase B; Provisional; Region: PRK00222 452637005243 SelR domain; Region: SelR; pfam01641 452637005244 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637005245 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637005246 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 452637005247 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637005248 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637005249 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 452637005250 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 452637005251 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 452637005252 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 452637005253 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 452637005254 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 452637005255 dimer interface [polypeptide binding]; other site 452637005256 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 452637005257 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637005258 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637005259 DNA binding residues [nucleotide binding] 452637005260 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 452637005261 Glycerate kinase family; Region: Gly_kinase; cl00841 452637005262 ATP cone domain; Region: ATP-cone; pfam03477 452637005263 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 452637005264 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 452637005265 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 452637005266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637005267 S-adenosylmethionine binding site [chemical binding]; other site 452637005268 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 452637005269 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 452637005270 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 452637005271 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637005272 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637005273 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452637005274 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637005275 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 452637005276 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637005277 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 452637005278 Family description; Region: VCBS; pfam13517 452637005279 Family description; Region: VCBS; pfam13517 452637005280 Family description; Region: VCBS; pfam13517 452637005281 Family description; Region: VCBS; pfam13517 452637005282 Family description; Region: VCBS; pfam13517 452637005283 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637005284 Family description; Region: VCBS; pfam13517 452637005285 Family description; Region: VCBS; pfam13517 452637005286 Family description; Region: VCBS; pfam13517 452637005287 Family description; Region: VCBS; pfam13517 452637005288 Family description; Region: VCBS; pfam13517 452637005289 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637005290 Family description; Region: VCBS; pfam13517 452637005291 Family description; Region: VCBS; pfam13517 452637005292 Family description; Region: VCBS; pfam13517 452637005293 Family description; Region: VCBS; pfam13517 452637005294 Family description; Region: VCBS; pfam13517 452637005295 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637005296 Family description; Region: VCBS; pfam13517 452637005297 Family description; Region: VCBS; pfam13517 452637005298 Family description; Region: VCBS; pfam13517 452637005299 Family description; Region: VCBS; pfam13517 452637005300 Family description; Region: VCBS; pfam13517 452637005301 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637005302 TIGR04076 family protein; Region: TIGR04076 452637005303 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 452637005304 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 452637005305 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 452637005306 Cu(I) binding site [ion binding]; other site 452637005307 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 452637005308 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 452637005309 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 452637005310 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 452637005311 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 452637005312 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 452637005313 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 452637005314 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 452637005315 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452637005316 Walker A/P-loop; other site 452637005317 ATP binding site [chemical binding]; other site 452637005318 Q-loop/lid; other site 452637005319 ABC transporter signature motif; other site 452637005320 Walker B; other site 452637005321 D-loop; other site 452637005322 H-loop/switch region; other site 452637005323 Predicted transcriptional regulator [Transcription]; Region: COG2378 452637005324 HTH domain; Region: HTH_11; cl17392 452637005325 WYL domain; Region: WYL; pfam13280 452637005326 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 452637005327 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 452637005328 active site 452637005329 Zn binding site [ion binding]; other site 452637005330 PAS fold; Region: PAS_4; pfam08448 452637005331 PAS domain S-box; Region: sensory_box; TIGR00229 452637005332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637005333 putative active site [active] 452637005334 heme pocket [chemical binding]; other site 452637005335 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452637005336 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452637005337 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 452637005338 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637005339 putative active site [active] 452637005340 heme pocket [chemical binding]; other site 452637005341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637005342 phosphorylation site [posttranslational modification] 452637005343 dimer interface [polypeptide binding]; other site 452637005344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637005345 ATP binding site [chemical binding]; other site 452637005346 Mg2+ binding site [ion binding]; other site 452637005347 G-X-G motif; other site 452637005348 Response regulator receiver domain; Region: Response_reg; pfam00072 452637005349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637005350 active site 452637005351 phosphorylation site [posttranslational modification] 452637005352 intermolecular recognition site; other site 452637005353 dimerization interface [polypeptide binding]; other site 452637005354 Rhomboid family; Region: Rhomboid; cl11446 452637005355 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005356 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005357 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005358 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 452637005359 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 452637005360 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 452637005361 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 452637005362 Predicted membrane protein [Function unknown]; Region: COG2311 452637005363 Protein of unknown function (DUF418); Region: DUF418; cl12135 452637005364 Protein of unknown function (DUF418); Region: DUF418; pfam04235 452637005365 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 452637005366 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637005367 TPR repeat; Region: TPR_11; pfam13414 452637005368 binding surface 452637005369 TPR motif; other site 452637005370 hypothetical protein; Provisional; Region: PRK09133 452637005371 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 452637005372 putative metal binding site [ion binding]; other site 452637005373 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 452637005374 Beta-propeller repeat; Region: SBBP; pfam06739 452637005375 Beta-propeller repeat; Region: SBBP; pfam06739 452637005376 Beta-propeller repeat; Region: SBBP; pfam06739 452637005377 Beta-propeller repeat; Region: SBBP; pfam06739 452637005378 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 452637005379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637005380 S-adenosylmethionine binding site [chemical binding]; other site 452637005381 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 452637005382 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005383 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005384 FtsX-like permease family; Region: FtsX; pfam02687 452637005385 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005386 FtsX-like permease family; Region: FtsX; pfam02687 452637005387 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005388 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005389 FtsX-like permease family; Region: FtsX; pfam02687 452637005390 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005391 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005392 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005393 FtsX-like permease family; Region: FtsX; pfam02687 452637005394 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005395 FtsX-like permease family; Region: FtsX; pfam02687 452637005396 Uncharacterized conserved protein [Function unknown]; Region: COG3595 452637005397 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 452637005398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452637005399 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452637005400 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 452637005401 intracellular protease, PfpI family; Region: PfpI; TIGR01382 452637005402 conserved cys residue [active] 452637005403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452637005404 Coenzyme A binding pocket [chemical binding]; other site 452637005405 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 452637005406 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452637005407 dimerization interface [polypeptide binding]; other site 452637005408 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637005409 dimer interface [polypeptide binding]; other site 452637005410 phosphorylation site [posttranslational modification] 452637005411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637005412 ATP binding site [chemical binding]; other site 452637005413 Mg2+ binding site [ion binding]; other site 452637005414 G-X-G motif; other site 452637005415 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452637005416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637005417 active site 452637005418 phosphorylation site [posttranslational modification] 452637005419 intermolecular recognition site; other site 452637005420 dimerization interface [polypeptide binding]; other site 452637005421 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452637005422 DNA binding site [nucleotide binding] 452637005423 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 452637005424 hypothetical protein; Provisional; Region: PRK10318 452637005425 Kelch domain; Region: Kelch; smart00612 452637005426 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 452637005427 Kelch motif; Region: Kelch_1; pfam01344 452637005428 Kelch motif; Region: Kelch_1; pfam01344 452637005429 Kelch motif; Region: Kelch_1; pfam01344 452637005430 Kelch motif; Region: Kelch_1; pfam01344 452637005431 phosphodiesterase YaeI; Provisional; Region: PRK11340 452637005432 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 452637005433 putative active site [active] 452637005434 putative metal binding site [ion binding]; other site 452637005435 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 452637005436 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 452637005437 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452637005438 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637005439 dimer interface [polypeptide binding]; other site 452637005440 phosphorylation site [posttranslational modification] 452637005441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637005442 ATP binding site [chemical binding]; other site 452637005443 Mg2+ binding site [ion binding]; other site 452637005444 G-X-G motif; other site 452637005445 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637005446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637005447 active site 452637005448 phosphorylation site [posttranslational modification] 452637005449 intermolecular recognition site; other site 452637005450 dimerization interface [polypeptide binding]; other site 452637005451 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 452637005452 active site 452637005453 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452637005454 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637005455 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637005456 DNA binding residues [nucleotide binding] 452637005457 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005458 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005459 FtsX-like permease family; Region: FtsX; pfam02687 452637005460 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005461 FtsX-like permease family; Region: FtsX; pfam02687 452637005462 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 452637005463 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005464 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005465 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005466 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005467 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005468 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 452637005469 FtsX-like permease family; Region: FtsX; pfam02687 452637005470 Predicted transcriptional regulators [Transcription]; Region: COG1695 452637005471 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 452637005472 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 452637005473 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 452637005474 FMN binding site [chemical binding]; other site 452637005475 dimer interface [polypeptide binding]; other site 452637005476 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452637005477 Coenzyme A binding pocket [chemical binding]; other site 452637005478 adenylate kinase; Reviewed; Region: adk; PRK00279 452637005479 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 452637005480 AMP-binding site [chemical binding]; other site 452637005481 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 452637005482 adenylate kinase; Reviewed; Region: adk; PRK00279 452637005483 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 452637005484 AMP-binding site [chemical binding]; other site 452637005485 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 452637005486 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 452637005487 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 452637005488 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452637005489 active site 452637005490 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 452637005491 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 452637005492 active site 452637005493 TDP-binding site; other site 452637005494 acceptor substrate-binding pocket; other site 452637005495 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005496 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005497 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005498 FtsX-like permease family; Region: FtsX; pfam02687 452637005499 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 452637005500 FMN binding site [chemical binding]; other site 452637005501 dimer interface [polypeptide binding]; other site 452637005502 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005503 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005504 FtsX-like permease family; Region: FtsX; pfam02687 452637005505 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005506 FtsX-like permease family; Region: FtsX; pfam02687 452637005507 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005508 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005509 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005510 FtsX-like permease family; Region: FtsX; pfam02687 452637005511 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005512 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005513 FtsX-like permease family; Region: FtsX; pfam02687 452637005514 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005515 FtsX-like permease family; Region: FtsX; pfam02687 452637005516 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005517 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005518 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005519 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005520 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005521 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005522 FtsX-like permease family; Region: FtsX; pfam02687 452637005523 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005524 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005525 FtsX-like permease family; Region: FtsX; pfam02687 452637005526 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005527 FtsX-like permease family; Region: FtsX; pfam02687 452637005528 SnoaL-like domain; Region: SnoaL_3; pfam13474 452637005529 TIGR04076 family protein; Region: TIGR04076 452637005530 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452637005531 Beta-lactamase; Region: Beta-lactamase; pfam00144 452637005532 SnoaL-like domain; Region: SnoaL_3; pfam13474 452637005533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637005534 TPR motif; other site 452637005535 binding surface 452637005536 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005537 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005538 FtsX-like permease family; Region: FtsX; pfam02687 452637005539 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005540 FtsX-like permease family; Region: FtsX; pfam02687 452637005541 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 452637005542 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005543 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005544 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005545 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005546 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005547 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005548 FtsX-like permease family; Region: FtsX; pfam02687 452637005549 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005550 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005551 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005552 FtsX-like permease family; Region: FtsX; pfam02687 452637005553 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005554 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005555 FtsX-like permease family; Region: FtsX; pfam02687 452637005556 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005557 FtsX-like permease family; Region: FtsX; pfam02687 452637005558 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005559 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005560 FtsX-like permease family; Region: FtsX; pfam02687 452637005561 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005562 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005563 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005564 FtsX-like permease family; Region: FtsX; pfam02687 452637005565 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005566 FtsX-like permease family; Region: FtsX; pfam02687 452637005567 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 452637005568 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 452637005569 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005570 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005571 FtsX-like permease family; Region: FtsX; pfam02687 452637005572 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005573 FtsX-like permease family; Region: FtsX; pfam02687 452637005574 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005575 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005576 FtsX-like permease family; Region: FtsX; pfam02687 452637005577 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005578 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005579 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005580 FtsX-like permease family; Region: FtsX; pfam02687 452637005581 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005582 FtsX-like permease family; Region: FtsX; pfam02687 452637005583 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005584 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005585 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005586 FtsX-like permease family; Region: FtsX; pfam02687 452637005587 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005588 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005589 FtsX-like permease family; Region: FtsX; pfam02687 452637005590 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005591 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005592 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005593 FtsX-like permease family; Region: FtsX; pfam02687 452637005594 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005595 FtsX-like permease family; Region: FtsX; pfam02687 452637005596 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005597 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005598 FtsX-like permease family; Region: FtsX; pfam02687 452637005599 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005600 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005601 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005602 FtsX-like permease family; Region: FtsX; pfam02687 452637005603 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005604 FtsX-like permease family; Region: FtsX; pfam02687 452637005605 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452637005606 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452637005607 Walker A/P-loop; other site 452637005608 ATP binding site [chemical binding]; other site 452637005609 Q-loop/lid; other site 452637005610 ABC transporter signature motif; other site 452637005611 Walker B; other site 452637005612 D-loop; other site 452637005613 H-loop/switch region; other site 452637005614 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 452637005615 HlyD family secretion protein; Region: HlyD_3; pfam13437 452637005616 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 452637005617 dimerization interface [polypeptide binding]; other site 452637005618 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 452637005619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637005620 ATP binding site [chemical binding]; other site 452637005621 Mg2+ binding site [ion binding]; other site 452637005622 G-X-G motif; other site 452637005623 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 452637005624 four helix bundle protein; Region: TIGR02436 452637005625 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 452637005626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637005627 active site 452637005628 phosphorylation site [posttranslational modification] 452637005629 intermolecular recognition site; other site 452637005630 dimerization interface [polypeptide binding]; other site 452637005631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637005632 Walker A motif; other site 452637005633 ATP binding site [chemical binding]; other site 452637005634 Walker B motif; other site 452637005635 arginine finger; other site 452637005636 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 452637005637 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637005638 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005639 FtsX-like permease family; Region: FtsX; pfam02687 452637005640 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637005641 FtsX-like permease family; Region: FtsX; pfam02687 452637005642 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 452637005643 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 452637005644 putative active site [active] 452637005645 putative metal binding site [ion binding]; other site 452637005646 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 452637005647 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 452637005648 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 452637005649 active site 452637005650 Zn binding site [ion binding]; other site 452637005651 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 452637005652 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 452637005653 active site 452637005654 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 452637005655 dimerization domain swap beta strand [polypeptide binding]; other site 452637005656 regulatory protein interface [polypeptide binding]; other site 452637005657 active site 452637005658 regulatory phosphorylation site [posttranslational modification]; other site 452637005659 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 452637005660 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 452637005661 Ligand binding site; other site 452637005662 oligomer interface; other site 452637005663 PAS domain; Region: PAS_9; pfam13426 452637005664 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637005665 PAS fold; Region: PAS_3; pfam08447 452637005666 putative active site [active] 452637005667 heme pocket [chemical binding]; other site 452637005668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637005669 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637005670 dimer interface [polypeptide binding]; other site 452637005671 phosphorylation site [posttranslational modification] 452637005672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637005673 ATP binding site [chemical binding]; other site 452637005674 Mg2+ binding site [ion binding]; other site 452637005675 G-X-G motif; other site 452637005676 Response regulator receiver domain; Region: Response_reg; pfam00072 452637005677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637005678 active site 452637005679 phosphorylation site [posttranslational modification] 452637005680 intermolecular recognition site; other site 452637005681 dimerization interface [polypeptide binding]; other site 452637005682 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 452637005683 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 452637005684 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 452637005685 catalytic site [active] 452637005686 subunit interface [polypeptide binding]; other site 452637005687 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 452637005688 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452637005689 FeS/SAM binding site; other site 452637005690 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 452637005691 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452637005692 active site 452637005693 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 452637005694 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637005695 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637005696 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 452637005697 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 452637005698 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 452637005699 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 452637005700 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 452637005701 catalytic residue [active] 452637005702 putative FPP diphosphate binding site; other site 452637005703 putative FPP binding hydrophobic cleft; other site 452637005704 dimer interface [polypeptide binding]; other site 452637005705 putative IPP diphosphate binding site; other site 452637005706 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 452637005707 aromatic arch; other site 452637005708 DCoH dimer interaction site [polypeptide binding]; other site 452637005709 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 452637005710 DCoH tetramer interaction site [polypeptide binding]; other site 452637005711 substrate binding site [chemical binding]; other site 452637005712 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 452637005713 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 452637005714 PLD-like domain; Region: PLDc_2; pfam13091 452637005715 putative active site [active] 452637005716 catalytic site [active] 452637005717 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 452637005718 PLD-like domain; Region: PLDc_2; pfam13091 452637005719 putative active site [active] 452637005720 catalytic site [active] 452637005721 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 452637005722 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 452637005723 glycine dehydrogenase; Provisional; Region: PRK05367 452637005724 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 452637005725 tetramer interface [polypeptide binding]; other site 452637005726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637005727 catalytic residue [active] 452637005728 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 452637005729 tetramer interface [polypeptide binding]; other site 452637005730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637005731 catalytic residue [active] 452637005732 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 452637005733 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 452637005734 minor groove reading motif; other site 452637005735 helix-hairpin-helix signature motif; other site 452637005736 substrate binding pocket [chemical binding]; other site 452637005737 active site 452637005738 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 452637005739 GIY-YIG motif/motif A; other site 452637005740 putative active site [active] 452637005741 putative metal binding site [ion binding]; other site 452637005742 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 452637005743 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 452637005744 active site 452637005745 catalytic residues [active] 452637005746 DNA binding site [nucleotide binding] 452637005747 Int/Topo IB signature motif; other site 452637005748 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 452637005749 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 452637005750 TrwC relaxase; Region: TrwC; pfam08751 452637005751 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 452637005752 AAA domain; Region: AAA_30; pfam13604 452637005753 AAA domain; Region: AAA_22; pfam13401 452637005754 Transposase; Region: HTH_Tnp_1; pfam01527 452637005755 putative transposase OrfB; Reviewed; Region: PHA02517 452637005756 HTH-like domain; Region: HTH_21; pfam13276 452637005757 Integrase core domain; Region: rve; pfam00665 452637005758 Integrase core domain; Region: rve_3; pfam13683 452637005759 ATP-grasp ribosomal peptide maturase, MvdC family; Region: ATPgraspMvdC; TIGR04185 452637005760 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452637005761 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 452637005762 Clp amino terminal domain; Region: Clp_N; pfam02861 452637005763 Clp amino terminal domain; Region: Clp_N; pfam02861 452637005764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637005765 Walker A motif; other site 452637005766 ATP binding site [chemical binding]; other site 452637005767 Walker B motif; other site 452637005768 arginine finger; other site 452637005769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637005770 Walker A motif; other site 452637005771 ATP binding site [chemical binding]; other site 452637005772 Walker B motif; other site 452637005773 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 452637005774 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452637005775 Beta-lactamase; Region: Beta-lactamase; pfam00144 452637005776 Protein of unknown function, DUF481; Region: DUF481; cl01213 452637005777 ParA-like protein; Provisional; Region: PHA02518 452637005778 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 452637005779 P-loop; other site 452637005780 Magnesium ion binding site [ion binding]; other site 452637005781 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 452637005782 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 452637005783 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452637005784 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 452637005785 Walker A/P-loop; other site 452637005786 ATP binding site [chemical binding]; other site 452637005787 Q-loop/lid; other site 452637005788 ABC transporter signature motif; other site 452637005789 Walker B; other site 452637005790 D-loop; other site 452637005791 H-loop/switch region; other site 452637005792 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 452637005793 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 452637005794 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 452637005795 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 452637005796 Thioesterase domain; Region: Thioesterase; pfam00975 452637005797 MbtH-like protein; Region: MbtH; cl01279 452637005798 acyl-CoA synthetase; Validated; Region: PRK05850 452637005799 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 452637005800 acyl-activating enzyme (AAE) consensus motif; other site 452637005801 active site 452637005802 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452637005803 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452637005804 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452637005805 active site 452637005806 Acyl transferase domain; Region: Acyl_transf_1; cl08282 452637005807 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 452637005808 KR domain; Region: KR; pfam08659 452637005809 putative NADP binding site [chemical binding]; other site 452637005810 active site 452637005811 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452637005812 hypothetical protein; Provisional; Region: PRK06761 452637005813 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452637005814 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 452637005815 active site 452637005816 Methyltransferase domain; Region: Methyltransf_12; pfam08242 452637005817 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 452637005818 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452637005819 putative NADP binding site [chemical binding]; other site 452637005820 active site 452637005821 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452637005822 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452637005823 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452637005824 active site 452637005825 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452637005826 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452637005827 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 452637005828 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452637005829 NADP binding site [chemical binding]; other site 452637005830 active site 452637005831 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452637005832 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 452637005833 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 452637005834 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452637005835 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452637005836 active site 452637005837 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 452637005838 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 452637005839 KR domain; Region: KR; pfam08659 452637005840 putative NADP binding site [chemical binding]; other site 452637005841 active site 452637005842 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 452637005843 Condensation domain; Region: Condensation; pfam00668 452637005844 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452637005845 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 452637005846 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452637005847 acyl-activating enzyme (AAE) consensus motif; other site 452637005848 AMP binding site [chemical binding]; other site 452637005849 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452637005850 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452637005851 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452637005852 active site 452637005853 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452637005854 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452637005855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452637005856 KR domain; Region: KR; pfam08659 452637005857 NAD(P) binding site [chemical binding]; other site 452637005858 active site 452637005859 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452637005860 Condensation domain; Region: Condensation; pfam00668 452637005861 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452637005862 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 452637005863 Condensation domain; Region: Condensation; pfam00668 452637005864 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452637005865 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 452637005866 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452637005867 acyl-activating enzyme (AAE) consensus motif; other site 452637005868 AMP binding site [chemical binding]; other site 452637005869 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452637005870 Condensation domain; Region: Condensation; pfam00668 452637005871 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452637005872 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 452637005873 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 452637005874 acyl-activating enzyme (AAE) consensus motif; other site 452637005875 AMP binding site [chemical binding]; other site 452637005876 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452637005877 Condensation domain; Region: Condensation; pfam00668 452637005878 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452637005879 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 452637005880 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452637005881 acyl-activating enzyme (AAE) consensus motif; other site 452637005882 AMP binding site [chemical binding]; other site 452637005883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637005884 S-adenosylmethionine binding site [chemical binding]; other site 452637005885 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452637005886 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452637005887 Condensation domain; Region: Condensation; pfam00668 452637005888 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452637005889 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 452637005890 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452637005891 acyl-activating enzyme (AAE) consensus motif; other site 452637005892 AMP binding site [chemical binding]; other site 452637005893 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452637005894 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 452637005895 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 452637005896 active site 452637005897 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452637005898 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 452637005899 Methyltransferase domain; Region: Methyltransf_23; pfam13489 452637005900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637005901 S-adenosylmethionine binding site [chemical binding]; other site 452637005902 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 452637005903 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 452637005904 putative NADP binding site [chemical binding]; other site 452637005905 active site 452637005906 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 452637005907 Enoylreductase; Region: PKS_ER; smart00829 452637005908 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 452637005909 NAD(P) binding site [chemical binding]; other site 452637005910 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452637005911 Condensation domain; Region: Condensation; pfam00668 452637005912 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452637005913 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 452637005914 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452637005915 acyl-activating enzyme (AAE) consensus motif; other site 452637005916 AMP binding site [chemical binding]; other site 452637005917 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452637005918 Condensation domain; Region: Condensation; pfam00668 452637005919 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 452637005920 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452637005921 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 452637005922 acyl-activating enzyme (AAE) consensus motif; other site 452637005923 AMP binding site [chemical binding]; other site 452637005924 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452637005925 Condensation domain; Region: Condensation; pfam00668 452637005926 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452637005927 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 452637005928 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 452637005929 acyl-activating enzyme (AAE) consensus motif; other site 452637005930 AMP binding site [chemical binding]; other site 452637005931 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452637005932 Condensation domain; Region: Condensation; pfam00668 452637005933 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 452637005934 Condensation domain; Region: Condensation; pfam00668 452637005935 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452637005936 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 452637005937 acyl-activating enzyme (AAE) consensus motif; other site 452637005938 AMP binding site [chemical binding]; other site 452637005939 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452637005940 Condensation domain; Region: Condensation; pfam00668 452637005941 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 452637005942 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 452637005943 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452637005944 Methyltransferase domain; Region: Methyltransf_31; pfam13847 452637005945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637005946 S-adenosylmethionine binding site [chemical binding]; other site 452637005947 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 452637005948 acyl-activating enzyme (AAE) consensus motif; other site 452637005949 AMP binding site [chemical binding]; other site 452637005950 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 452637005951 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 452637005952 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 452637005953 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 452637005954 inhibitor-cofactor binding pocket; inhibition site 452637005955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637005956 catalytic residue [active] 452637005957 Transposase IS200 like; Region: Y1_Tnp; cl00848 452637005958 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 452637005959 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 452637005960 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 452637005961 active site residue [active] 452637005962 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 452637005963 active site residue [active] 452637005964 Fe-S metabolism associated domain; Region: SufE; cl00951 452637005965 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452637005966 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 452637005967 dimer interface [polypeptide binding]; other site 452637005968 active site 452637005969 metal binding site [ion binding]; metal-binding site 452637005970 glutathione binding site [chemical binding]; other site 452637005971 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 452637005972 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 452637005973 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 452637005974 helix-hairpin-helix signature motif; other site 452637005975 substrate binding pocket [chemical binding]; other site 452637005976 active site 452637005977 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 452637005978 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 452637005979 peptide binding site [polypeptide binding]; other site 452637005980 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452637005981 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452637005982 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 452637005983 Walker A/P-loop; other site 452637005984 ATP binding site [chemical binding]; other site 452637005985 Q-loop/lid; other site 452637005986 ABC transporter signature motif; other site 452637005987 Walker B; other site 452637005988 D-loop; other site 452637005989 H-loop/switch region; other site 452637005990 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452637005991 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452637005992 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637005993 Walker A/P-loop; other site 452637005994 ATP binding site [chemical binding]; other site 452637005995 Q-loop/lid; other site 452637005996 ABC transporter signature motif; other site 452637005997 Walker B; other site 452637005998 D-loop; other site 452637005999 H-loop/switch region; other site 452637006000 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452637006001 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637006002 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637006003 DNA binding residues [nucleotide binding] 452637006004 von Willebrand factor; Region: vWF_A; pfam12450 452637006005 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 452637006006 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 452637006007 metal ion-dependent adhesion site (MIDAS); other site 452637006008 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 452637006009 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637006010 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637006011 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 452637006012 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 452637006013 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637006014 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452637006015 DNA binding site [nucleotide binding] 452637006016 domain linker motif; other site 452637006017 Periplasmic binding protein-like domain; Region: Peripla_BP_3; pfam13377 452637006018 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637006019 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637006020 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637006021 FtsX-like permease family; Region: FtsX; pfam02687 452637006022 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637006023 FtsX-like permease family; Region: FtsX; pfam02687 452637006024 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637006025 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637006026 FtsX-like permease family; Region: FtsX; pfam02687 452637006027 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637006028 FtsX-like permease family; Region: FtsX; pfam02687 452637006029 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452637006030 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 452637006031 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 452637006032 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 452637006033 Immunoglobulin I-set domain; Region: I-set; pfam07679 452637006034 Immunoglobulin domain; Region: Ig; cd00096 452637006035 TPR repeat; Region: TPR_11; pfam13414 452637006036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637006037 TPR motif; other site 452637006038 binding surface 452637006039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637006040 TPR motif; other site 452637006041 TPR repeat; Region: TPR_11; pfam13414 452637006042 binding surface 452637006043 TPR repeat; Region: TPR_11; pfam13414 452637006044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637006045 binding surface 452637006046 TPR motif; other site 452637006047 TPR repeat; Region: TPR_11; pfam13414 452637006048 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 452637006049 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452637006050 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 452637006051 ACT domain; Region: ACT_6; pfam13740 452637006052 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 452637006053 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452637006054 GAF domain; Region: GAF; pfam01590 452637006055 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452637006056 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452637006057 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637006058 dimer interface [polypeptide binding]; other site 452637006059 phosphorylation site [posttranslational modification] 452637006060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637006061 ATP binding site [chemical binding]; other site 452637006062 Mg2+ binding site [ion binding]; other site 452637006063 G-X-G motif; other site 452637006064 PII uridylyl-transferase; Provisional; Region: PRK05092 452637006065 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 452637006066 metal binding triad; other site 452637006067 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 452637006068 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 452637006069 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 452637006070 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 452637006071 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452637006072 active site 452637006073 HIGH motif; other site 452637006074 nucleotide binding site [chemical binding]; other site 452637006075 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 452637006076 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 452637006077 active site 452637006078 KMSKS motif; other site 452637006079 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 452637006080 tRNA binding surface [nucleotide binding]; other site 452637006081 anticodon binding site; other site 452637006082 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 452637006083 Response regulator receiver domain; Region: Response_reg; pfam00072 452637006084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637006085 active site 452637006086 phosphorylation site [posttranslational modification] 452637006087 intermolecular recognition site; other site 452637006088 dimerization interface [polypeptide binding]; other site 452637006089 heat shock protein 90; Provisional; Region: PRK05218 452637006090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637006091 ATP binding site [chemical binding]; other site 452637006092 Mg2+ binding site [ion binding]; other site 452637006093 G-X-G motif; other site 452637006094 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 452637006095 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 452637006096 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 452637006097 active site 452637006098 catalytic site [active] 452637006099 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 452637006100 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 452637006101 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 452637006102 catalytic site [active] 452637006103 active site 452637006104 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 452637006105 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 452637006106 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 452637006107 active site 452637006108 catalytic site [active] 452637006109 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 452637006110 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 452637006111 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 452637006112 Walker A/P-loop; other site 452637006113 ATP binding site [chemical binding]; other site 452637006114 Q-loop/lid; other site 452637006115 ABC transporter signature motif; other site 452637006116 Walker B; other site 452637006117 D-loop; other site 452637006118 H-loop/switch region; other site 452637006119 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 452637006120 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 452637006121 Walker A/P-loop; other site 452637006122 ATP binding site [chemical binding]; other site 452637006123 Q-loop/lid; other site 452637006124 ABC transporter signature motif; other site 452637006125 Walker B; other site 452637006126 D-loop; other site 452637006127 H-loop/switch region; other site 452637006128 Bacterial PH domain; Region: DUF304; pfam03703 452637006129 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 452637006130 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 452637006131 TM-ABC transporter signature motif; other site 452637006132 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 452637006133 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 452637006134 TM-ABC transporter signature motif; other site 452637006135 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 452637006136 four helix bundle protein; Region: TIGR02436 452637006137 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 452637006138 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 452637006139 putative ligand binding site [chemical binding]; other site 452637006140 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 452637006141 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 452637006142 putative ligand binding site [chemical binding]; other site 452637006143 Predicted permeases [General function prediction only]; Region: COG0795 452637006144 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 452637006145 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 452637006146 classical (c) SDRs; Region: SDR_c; cd05233 452637006147 NAD(P) binding site [chemical binding]; other site 452637006148 active site 452637006149 SeqA protein; Region: SeqA; cl11470 452637006150 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 452637006151 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 452637006152 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 452637006153 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 452637006154 acetolactate synthase; Region: PLN02470 452637006155 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 452637006156 PYR/PP interface [polypeptide binding]; other site 452637006157 dimer interface [polypeptide binding]; other site 452637006158 TPP binding site [chemical binding]; other site 452637006159 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 452637006160 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 452637006161 TPP-binding site [chemical binding]; other site 452637006162 dimer interface [polypeptide binding]; other site 452637006163 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 452637006164 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 452637006165 putative active site [active] 452637006166 metal binding site [ion binding]; metal-binding site 452637006167 homodimer binding site [polypeptide binding]; other site 452637006168 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 452637006169 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 452637006170 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 452637006171 active site clefts [active] 452637006172 zinc binding site [ion binding]; other site 452637006173 dimer interface [polypeptide binding]; other site 452637006174 PspC domain; Region: PspC; pfam04024 452637006175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 452637006176 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 452637006177 Uncharacterized conserved protein [Function unknown]; Region: COG2353 452637006178 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 452637006179 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 452637006180 Cupin domain; Region: Cupin_2; pfam07883 452637006181 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 452637006182 catalytic triad [active] 452637006183 putative active site [active] 452637006184 Immunoglobulin I-set domain; Region: I-set; pfam07679 452637006185 Pectate lyase; Region: Pec_lyase_C; cl01593 452637006186 Right handed beta helix region; Region: Beta_helix; pfam13229 452637006187 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 452637006188 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 452637006189 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 452637006190 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 452637006191 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 452637006192 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637006193 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637006194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637006195 MFS/sugar transport protein; Region: MFS_2; pfam13347 452637006196 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637006197 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452637006198 DNA binding site [nucleotide binding] 452637006199 domain linker motif; other site 452637006200 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 452637006201 ligand binding site [chemical binding]; other site 452637006202 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 452637006203 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 452637006204 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 452637006205 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 452637006206 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 452637006207 NEF interaction site [polypeptide binding]; other site 452637006208 nucleotide binding site [chemical binding]; other site 452637006209 SBD interface [polypeptide binding]; other site 452637006210 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 452637006211 oligomerisation interface [polypeptide binding]; other site 452637006212 mobile loop; other site 452637006213 roof hairpin; other site 452637006214 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 452637006215 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 452637006216 ring oligomerisation interface [polypeptide binding]; other site 452637006217 ATP/Mg binding site [chemical binding]; other site 452637006218 stacking interactions; other site 452637006219 hinge regions; other site 452637006220 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 452637006221 SLBB domain; Region: SLBB; pfam10531 452637006222 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 452637006223 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 452637006224 putative hexamer interface [polypeptide binding]; other site 452637006225 putative hexagonal pore; other site 452637006226 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 452637006227 putative hexamer interface [polypeptide binding]; other site 452637006228 putative hexagonal pore; other site 452637006229 putative hydrolase; Provisional; Region: PRK02113 452637006230 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 452637006231 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 452637006232 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 452637006233 nucleotide binding pocket [chemical binding]; other site 452637006234 K-X-D-G motif; other site 452637006235 catalytic site [active] 452637006236 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 452637006237 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 452637006238 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 452637006239 Dimer interface [polypeptide binding]; other site 452637006240 Predicted transcriptional regulator [Transcription]; Region: COG1959 452637006241 Transcriptional regulator; Region: Rrf2; pfam02082 452637006242 FlxA-like protein; Region: FlxA; pfam14282 452637006243 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 452637006244 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 452637006245 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 452637006246 substrate binding pocket [chemical binding]; other site 452637006247 membrane-bound complex binding site; other site 452637006248 hinge residues; other site 452637006249 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 452637006250 active site 452637006251 Zn binding site [ion binding]; other site 452637006252 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 452637006253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452637006254 dimer interface [polypeptide binding]; other site 452637006255 conserved gate region; other site 452637006256 putative PBP binding loops; other site 452637006257 ABC-ATPase subunit interface; other site 452637006258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452637006259 dimer interface [polypeptide binding]; other site 452637006260 conserved gate region; other site 452637006261 putative PBP binding loops; other site 452637006262 ABC-ATPase subunit interface; other site 452637006263 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 452637006264 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 452637006265 Walker A/P-loop; other site 452637006266 ATP binding site [chemical binding]; other site 452637006267 Q-loop/lid; other site 452637006268 ABC transporter signature motif; other site 452637006269 Walker B; other site 452637006270 D-loop; other site 452637006271 H-loop/switch region; other site 452637006272 TOBE-like domain; Region: TOBE_3; pfam12857 452637006273 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 452637006274 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 452637006275 TrkA-C domain; Region: TrkA_C; pfam02080 452637006276 TrkA-C domain; Region: TrkA_C; pfam02080 452637006277 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 452637006278 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 452637006279 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 452637006280 dimer interface [polypeptide binding]; other site 452637006281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637006282 catalytic residue [active] 452637006283 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 452637006284 Heme/copper-type cytochrome/quinol oxidase, subunit 3 [Energy production and conversion]; Region: CyoC; COG1845 452637006285 Subunit I/III interface [polypeptide binding]; other site 452637006286 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 452637006287 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 452637006288 D-pathway; other site 452637006289 Putative ubiquinol binding site [chemical binding]; other site 452637006290 Low-spin heme (heme b) binding site [chemical binding]; other site 452637006291 Putative water exit pathway; other site 452637006292 Binuclear center (heme o3/CuB) [ion binding]; other site 452637006293 K-pathway; other site 452637006294 Putative proton exit pathway; other site 452637006295 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 452637006296 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 452637006297 Cytochrome c; Region: Cytochrom_C; pfam00034 452637006298 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 452637006299 Protein of unknown function (DUF420); Region: DUF420; pfam04238 452637006300 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 452637006301 UbiA prenyltransferase family; Region: UbiA; pfam01040 452637006302 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 452637006303 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 452637006304 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 452637006305 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 452637006306 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 452637006307 Cu(I) binding site [ion binding]; other site 452637006308 AMP nucleosidase; Provisional; Region: PRK07115 452637006309 lipoyl synthase; Provisional; Region: PRK05481 452637006310 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452637006311 FeS/SAM binding site; other site 452637006312 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 452637006313 Predicted membrane protein [Function unknown]; Region: COG3174 452637006314 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 452637006315 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 452637006316 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 452637006317 dimer interface [polypeptide binding]; other site 452637006318 putative anticodon binding site; other site 452637006319 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 452637006320 motif 1; other site 452637006321 dimer interface [polypeptide binding]; other site 452637006322 active site 452637006323 motif 2; other site 452637006324 motif 3; other site 452637006325 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 452637006326 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637006327 FtsX-like permease family; Region: FtsX; pfam02687 452637006328 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452637006329 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452637006330 Walker A/P-loop; other site 452637006331 ATP binding site [chemical binding]; other site 452637006332 Q-loop/lid; other site 452637006333 ABC transporter signature motif; other site 452637006334 Walker B; other site 452637006335 D-loop; other site 452637006336 H-loop/switch region; other site 452637006337 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637006338 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637006339 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 452637006340 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 452637006341 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 452637006342 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 452637006343 tRNA; other site 452637006344 putative tRNA binding site [nucleotide binding]; other site 452637006345 putative NADP binding site [chemical binding]; other site 452637006346 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 452637006347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637006348 S-adenosylmethionine binding site [chemical binding]; other site 452637006349 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 452637006350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637006351 S-adenosylmethionine binding site [chemical binding]; other site 452637006352 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 452637006353 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 452637006354 active site 452637006355 PHP Thumb interface [polypeptide binding]; other site 452637006356 metal binding site [ion binding]; metal-binding site 452637006357 VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal...; Region: VHS_ENTH_ANTH; cl02544 452637006358 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 452637006359 generic binding surface II; other site 452637006360 generic binding surface I; other site 452637006361 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 452637006362 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 452637006363 Metal-binding active site; metal-binding site 452637006364 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 452637006365 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 452637006366 catalytic residues [active] 452637006367 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 452637006368 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 452637006369 minor groove reading motif; other site 452637006370 helix-hairpin-helix signature motif; other site 452637006371 substrate binding pocket [chemical binding]; other site 452637006372 active site 452637006373 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 452637006374 ribonuclease HIII; Provisional; Region: PRK00996 452637006375 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 452637006376 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 452637006377 RNA/DNA hybrid binding site [nucleotide binding]; other site 452637006378 active site 452637006379 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 452637006380 RNA/DNA hybrid binding site [nucleotide binding]; other site 452637006381 active site 452637006382 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 452637006383 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637006384 putative active site [active] 452637006385 heme pocket [chemical binding]; other site 452637006386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637006387 dimer interface [polypeptide binding]; other site 452637006388 phosphorylation site [posttranslational modification] 452637006389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637006390 ATP binding site [chemical binding]; other site 452637006391 Mg2+ binding site [ion binding]; other site 452637006392 G-X-G motif; other site 452637006393 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 452637006394 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637006395 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637006396 DNA binding residues [nucleotide binding] 452637006397 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 452637006398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637006399 active site 452637006400 phosphorylation site [posttranslational modification] 452637006401 intermolecular recognition site; other site 452637006402 dimerization interface [polypeptide binding]; other site 452637006403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637006404 Walker A motif; other site 452637006405 ATP binding site [chemical binding]; other site 452637006406 Walker B motif; other site 452637006407 arginine finger; other site 452637006408 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 452637006409 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 452637006410 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 452637006411 Chain length determinant protein; Region: Wzz; cl15801 452637006412 Chain length determinant protein; Region: Wzz; cl15801 452637006413 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 452637006414 amidophosphoribosyltransferase; Region: purF; TIGR01134 452637006415 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 452637006416 active site 452637006417 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 452637006418 active site 452637006419 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 452637006420 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 452637006421 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 452637006422 active site 452637006423 HIGH motif; other site 452637006424 dimer interface [polypeptide binding]; other site 452637006425 KMSKS motif; other site 452637006426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637006427 S-adenosylmethionine binding site [chemical binding]; other site 452637006428 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 452637006429 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 452637006430 putative acyl-acceptor binding pocket; other site 452637006431 cytidylate kinase; Provisional; Region: cmk; PRK00023 452637006432 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 452637006433 CMP-binding site; other site 452637006434 The sites determining sugar specificity; other site 452637006435 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 452637006436 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 452637006437 hinge; other site 452637006438 active site 452637006439 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 452637006440 prephenate dehydrogenase; Validated; Region: PRK08507 452637006441 EVE domain; Region: EVE; pfam01878 452637006442 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 452637006443 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 452637006444 putative active site [active] 452637006445 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 452637006446 Uncharacterized conserved protein [Function unknown]; Region: COG1262 452637006447 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 452637006448 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 452637006449 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 452637006450 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 452637006451 Fibronectin type 3 domain; Region: FN3; smart00060 452637006452 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 452637006453 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 452637006454 putative NAD(P) binding site [chemical binding]; other site 452637006455 putative substrate binding site [chemical binding]; other site 452637006456 catalytic Zn binding site [ion binding]; other site 452637006457 structural Zn binding site [ion binding]; other site 452637006458 dimer interface [polypeptide binding]; other site 452637006459 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 452637006460 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 452637006461 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637006462 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 452637006463 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637006464 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 452637006465 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 452637006466 active site 452637006467 catalytic triad [active] 452637006468 oxyanion hole [active] 452637006469 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 452637006470 trimer interface [polypeptide binding]; other site 452637006471 active site 452637006472 Predicted flavoprotein [General function prediction only]; Region: COG0431 452637006473 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 452637006474 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 452637006475 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 452637006476 DNA binding residues [nucleotide binding] 452637006477 dimer interface [polypeptide binding]; other site 452637006478 [2Fe-2S] cluster binding site [ion binding]; other site 452637006479 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 452637006480 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 452637006481 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637006482 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637006483 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 452637006484 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 452637006485 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 452637006486 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 452637006487 BNR repeat-like domain; Region: BNR_2; pfam13088 452637006488 Uncharacterized conserved protein [Function unknown]; Region: COG2006 452637006489 Domain of unknown function (DUF362); Region: DUF362; pfam04015 452637006490 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 452637006491 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 452637006492 Two component regulator propeller; Region: Reg_prop; pfam07494 452637006493 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 452637006494 PAS fold; Region: PAS_4; pfam08448 452637006495 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637006496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637006497 ATP binding site [chemical binding]; other site 452637006498 Mg2+ binding site [ion binding]; other site 452637006499 G-X-G motif; other site 452637006500 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 452637006501 GTP cyclohydrolase I; Provisional; Region: PLN03044 452637006502 active site 452637006503 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 452637006504 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452637006505 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 452637006506 putative acyl-acceptor binding pocket; other site 452637006507 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 452637006508 apolar tunnel; other site 452637006509 heme binding site [chemical binding]; other site 452637006510 dimerization interface [polypeptide binding]; other site 452637006511 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 452637006512 EF-hand domain pair; Region: EF_hand_5; pfam13499 452637006513 Ca2+ binding site [ion binding]; other site 452637006514 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 452637006515 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452637006516 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452637006517 active site 452637006518 catalytic tetrad [active] 452637006519 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 452637006520 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 452637006521 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 452637006522 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 452637006523 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 452637006524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637006525 dimer interface [polypeptide binding]; other site 452637006526 phosphorylation site [posttranslational modification] 452637006527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637006528 ATP binding site [chemical binding]; other site 452637006529 Mg2+ binding site [ion binding]; other site 452637006530 G-X-G motif; other site 452637006531 Response regulator receiver domain; Region: Response_reg; pfam00072 452637006532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637006533 active site 452637006534 phosphorylation site [posttranslational modification] 452637006535 intermolecular recognition site; other site 452637006536 dimerization interface [polypeptide binding]; other site 452637006537 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 452637006538 CoenzymeA binding site [chemical binding]; other site 452637006539 subunit interaction site [polypeptide binding]; other site 452637006540 PHB binding site; other site 452637006541 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 452637006542 MG2 domain; Region: A2M_N; pfam01835 452637006543 Alpha-2-macroglobulin family; Region: A2M; pfam00207 452637006544 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 452637006545 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 452637006546 Protein of unknown function (DUF3160); Region: DUF3160; pfam11369 452637006547 PAS domain S-box; Region: sensory_box; TIGR00229 452637006548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637006549 putative active site [active] 452637006550 heme pocket [chemical binding]; other site 452637006551 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637006552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637006553 ATP binding site [chemical binding]; other site 452637006554 Mg2+ binding site [ion binding]; other site 452637006555 G-X-G motif; other site 452637006556 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 452637006557 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452637006558 PAS domain; Region: PAS; smart00091 452637006559 PAS domain; Region: PAS_9; pfam13426 452637006560 putative active site [active] 452637006561 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 452637006562 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 452637006563 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 452637006564 Immunoglobulin domain; Region: Ig_2; pfam13895 452637006565 A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603 452637006566 ligand binding surface [chemical binding]; other site 452637006567 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 452637006568 RHS Repeat; Region: RHS_repeat; pfam05593 452637006569 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 452637006570 RHS Repeat; Region: RHS_repeat; cl11982 452637006571 RHS Repeat; Region: RHS_repeat; cl11982 452637006572 RHS Repeat; Region: RHS_repeat; pfam05593 452637006573 RHS Repeat; Region: RHS_repeat; pfam05593 452637006574 RHS Repeat; Region: RHS_repeat; pfam05593 452637006575 RHS Repeat; Region: RHS_repeat; pfam05593 452637006576 RHS Repeat; Region: RHS_repeat; pfam05593 452637006577 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 452637006578 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637006579 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637006580 dimer interface [polypeptide binding]; other site 452637006581 phosphorylation site [posttranslational modification] 452637006582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637006583 ATP binding site [chemical binding]; other site 452637006584 Mg2+ binding site [ion binding]; other site 452637006585 G-X-G motif; other site 452637006586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637006587 Response regulator receiver domain; Region: Response_reg; pfam00072 452637006588 active site 452637006589 phosphorylation site [posttranslational modification] 452637006590 intermolecular recognition site; other site 452637006591 dimerization interface [polypeptide binding]; other site 452637006592 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 452637006593 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 452637006594 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 452637006595 putative NADH binding site [chemical binding]; other site 452637006596 putative active site [active] 452637006597 nudix motif; other site 452637006598 putative metal binding site [ion binding]; other site 452637006599 SnoaL-like domain; Region: SnoaL_2; pfam12680 452637006600 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 452637006601 Chromate transporter; Region: Chromate_transp; pfam02417 452637006602 Predicted membrane protein [Function unknown]; Region: COG2259 452637006603 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452637006604 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 452637006605 active site 452637006606 nucleotide binding site [chemical binding]; other site 452637006607 HIGH motif; other site 452637006608 KMSKS motif; other site 452637006609 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 452637006610 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 452637006611 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 452637006612 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 452637006613 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 452637006614 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 452637006615 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452637006616 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 452637006617 Immunoglobulin domain; Region: Ig; cd00096 452637006618 Immunoglobulin I-set domain; Region: I-set; pfam07679 452637006619 Immunoglobulin domain; Region: Ig_2; pfam13895 452637006620 Immunoglobulin domain; Region: Ig_2; pfam13895 452637006621 Immunoglobulin I-set domain; Region: I-set; pfam07679 452637006622 Immunoglobulin domain; Region: Ig_2; pfam13895 452637006623 Immunoglobulin domain; Region: Ig; cl11960 452637006624 Immunoglobulin C-2 Type; Region: IGc2; smart00408 452637006625 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 452637006626 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 452637006627 fructuronate transporter; Provisional; Region: PRK10034; cl15264 452637006628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637006629 putative substrate translocation pore; other site 452637006630 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 452637006631 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 452637006632 PQQ-like domain; Region: PQQ_2; pfam13360 452637006633 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 452637006634 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 452637006635 active site 452637006636 PQQ-like domain; Region: PQQ_2; pfam13360 452637006637 Trp docking motif [polypeptide binding]; other site 452637006638 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 452637006639 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 452637006640 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 452637006641 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452637006642 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452637006643 active site 452637006644 catalytic tetrad [active] 452637006645 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 452637006646 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 452637006647 Rhomboid family; Region: Rhomboid; pfam01694 452637006648 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 452637006649 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637006650 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637006651 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 452637006652 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 452637006653 Predicted membrane protein [Function unknown]; Region: COG2323 452637006654 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 452637006655 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 452637006656 HlyD family secretion protein; Region: HlyD_3; pfam13437 452637006657 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637006658 FtsX-like permease family; Region: FtsX; pfam02687 452637006659 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452637006660 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452637006661 Walker A/P-loop; other site 452637006662 ATP binding site [chemical binding]; other site 452637006663 Q-loop/lid; other site 452637006664 ABC transporter signature motif; other site 452637006665 Walker B; other site 452637006666 D-loop; other site 452637006667 H-loop/switch region; other site 452637006668 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cd10320 452637006669 active site 452637006670 catalytic site [active] 452637006671 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 452637006672 C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317 452637006673 Ca binding site [ion binding]; other site 452637006674 substrate binding site [chemical binding]; other site 452637006675 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 452637006676 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 452637006677 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 452637006678 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 452637006679 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 452637006680 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 452637006681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637006682 TPR repeat; Region: TPR_11; pfam13414 452637006683 binding surface 452637006684 TPR motif; other site 452637006685 PAS fold; Region: PAS_4; pfam08448 452637006686 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637006687 putative active site [active] 452637006688 heme pocket [chemical binding]; other site 452637006689 PAS fold; Region: PAS_4; pfam08448 452637006690 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637006691 dimer interface [polypeptide binding]; other site 452637006692 phosphorylation site [posttranslational modification] 452637006693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637006694 ATP binding site [chemical binding]; other site 452637006695 Mg2+ binding site [ion binding]; other site 452637006696 G-X-G motif; other site 452637006697 Response regulator receiver domain; Region: Response_reg; pfam00072 452637006698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637006699 active site 452637006700 phosphorylation site [posttranslational modification] 452637006701 intermolecular recognition site; other site 452637006702 dimerization interface [polypeptide binding]; other site 452637006703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637006704 Response regulator receiver domain; Region: Response_reg; pfam00072 452637006705 active site 452637006706 phosphorylation site [posttranslational modification] 452637006707 intermolecular recognition site; other site 452637006708 dimerization interface [polypeptide binding]; other site 452637006709 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637006710 dimer interface [polypeptide binding]; other site 452637006711 phosphorylation site [posttranslational modification] 452637006712 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637006713 ATP binding site [chemical binding]; other site 452637006714 Mg2+ binding site [ion binding]; other site 452637006715 G-X-G motif; other site 452637006716 Response regulator receiver domain; Region: Response_reg; pfam00072 452637006717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637006718 active site 452637006719 phosphorylation site [posttranslational modification] 452637006720 intermolecular recognition site; other site 452637006721 dimerization interface [polypeptide binding]; other site 452637006722 Nudix hydrolase homolog; Region: PLN02791 452637006723 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 452637006724 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 452637006725 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 452637006726 homotrimer interaction site [polypeptide binding]; other site 452637006727 putative active site [active] 452637006728 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153 452637006729 homotrimer interaction site [polypeptide binding]; other site 452637006730 putative active site [active] 452637006731 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 452637006732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637006733 putative substrate translocation pore; other site 452637006734 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 452637006735 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 452637006736 HlyD family secretion protein; Region: HlyD_3; pfam13437 452637006737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452637006738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452637006739 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 452637006740 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 452637006741 Helix-turn-helix domain; Region: HTH_17; pfam12728 452637006742 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 452637006743 active site 452637006744 phosphorylation site [posttranslational modification] 452637006745 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 452637006746 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 452637006747 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 452637006748 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 452637006749 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 452637006750 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452637006751 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 452637006752 dimerization interface [polypeptide binding]; other site 452637006753 substrate binding pocket [chemical binding]; other site 452637006754 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 452637006755 YceI-like domain; Region: YceI; pfam04264 452637006756 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 452637006757 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 452637006758 homoserine dehydrogenase; Provisional; Region: PRK06349 452637006759 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 452637006760 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 452637006761 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 452637006762 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 452637006763 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 452637006764 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 452637006765 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 452637006766 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 452637006767 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 452637006768 active site 452637006769 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637006770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637006771 active site 452637006772 phosphorylation site [posttranslational modification] 452637006773 intermolecular recognition site; other site 452637006774 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637006775 DNA binding residues [nucleotide binding] 452637006776 dimerization interface [polypeptide binding]; other site 452637006777 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 452637006778 Catalytic site [active] 452637006779 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 452637006780 metal binding site [ion binding]; metal-binding site 452637006781 FOG: WD40 repeat [General function prediction only]; Region: COG2319 452637006782 active site 452637006783 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 452637006784 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637006785 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637006786 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452637006787 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637006788 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637006789 DNA binding residues [nucleotide binding] 452637006790 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 452637006791 GIY-YIG motif/motif A; other site 452637006792 putative active site [active] 452637006793 putative metal binding site [ion binding]; other site 452637006794 HNH endonuclease; Region: HNH_2; pfam13391 452637006795 HNH endonuclease; Region: HNH_2; pfam13391 452637006796 Protein of unknown function DUF262; Region: DUF262; pfam03235 452637006797 Uncharacterized conserved protein [Function unknown]; Region: COG1479 452637006798 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 452637006799 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 452637006800 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 452637006801 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452637006802 active site 452637006803 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452637006804 Beta-lactamase; Region: Beta-lactamase; pfam00144 452637006805 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 452637006806 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452637006807 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 452637006808 DNA binding residues [nucleotide binding] 452637006809 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 452637006810 dimer interface [polypeptide binding]; other site 452637006811 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637006812 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637006813 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637006814 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637006815 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 452637006816 Immunoglobulin domain; Region: Ig_2; pfam13895 452637006817 Immunoglobulin I-set domain; Region: I-set; pfam07679 452637006818 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cd10546 452637006819 putative active site [active] 452637006820 redox center [active] 452637006821 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 452637006822 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 452637006823 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 452637006824 RibD C-terminal domain; Region: RibD_C; cl17279 452637006825 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 452637006826 SnoaL-like domain; Region: SnoaL_2; pfam12680 452637006827 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 452637006828 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 452637006829 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 452637006830 NHL repeat; Region: NHL; pfam01436 452637006831 NHL repeat; Region: NHL; pfam01436 452637006832 NHL repeat; Region: NHL; pfam01436 452637006833 NHL repeat; Region: NHL; pfam01436 452637006834 NHL repeat; Region: NHL; pfam01436 452637006835 NHL repeat; Region: NHL; pfam01436 452637006836 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 452637006837 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 452637006838 ArsC family; Region: ArsC; pfam03960 452637006839 putative ArsC-like catalytic residues; other site 452637006840 putative TRX-like catalytic residues [active] 452637006841 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 452637006842 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452637006843 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 452637006844 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452637006845 Protein of unknown function (DUF419); Region: DUF419; pfam04237 452637006846 Family description; Region: VCBS; pfam13517 452637006847 Family description; Region: VCBS; pfam13517 452637006848 Family description; Region: VCBS; pfam13517 452637006849 Family description; Region: VCBS; pfam13517 452637006850 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637006851 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 452637006852 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 452637006853 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 452637006854 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 452637006855 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 452637006856 putative hydrophobic ligand binding site [chemical binding]; other site 452637006857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637006858 Response regulator receiver domain; Region: Response_reg; pfam00072 452637006859 active site 452637006860 phosphorylation site [posttranslational modification] 452637006861 intermolecular recognition site; other site 452637006862 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 452637006863 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452637006864 putative metal binding site [ion binding]; other site 452637006865 Uncharacterized conserved protein [Function unknown]; Region: COG2353 452637006866 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 452637006867 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 452637006868 5S rRNA interface [nucleotide binding]; other site 452637006869 CTC domain interface [polypeptide binding]; other site 452637006870 L16 interface [polypeptide binding]; other site 452637006871 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 452637006872 putative active site [active] 452637006873 catalytic residue [active] 452637006874 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 452637006875 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 452637006876 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 452637006877 dimer interface [polypeptide binding]; other site 452637006878 ssDNA binding site [nucleotide binding]; other site 452637006879 tetramer (dimer of dimers) interface [polypeptide binding]; other site 452637006880 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 452637006881 active site 452637006882 Int/Topo IB signature motif; other site 452637006883 catalytic residues [active] 452637006884 DNA binding site [nucleotide binding] 452637006885 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 452637006886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 452637006887 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452637006888 non-specific DNA binding site [nucleotide binding]; other site 452637006889 salt bridge; other site 452637006890 sequence-specific DNA binding site [nucleotide binding]; other site 452637006891 AAA domain; Region: AAA_23; pfam13476 452637006892 P-loop containing region of AAA domain; Region: AAA_29; cl17516 452637006893 AAA domain; Region: AAA_21; pfam13304 452637006894 NACHT domain; Region: NACHT; pfam05729 452637006895 AAA domain; Region: AAA_17; pfam13207 452637006896 Radical SAM superfamily; Region: Radical_SAM; pfam04055 452637006897 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 452637006898 LexA repressor; Validated; Region: PRK00215 452637006899 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 452637006900 Catalytic site [active] 452637006901 alpha-galactosidase; Region: PLN02808; cl17638 452637006902 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 452637006903 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 452637006904 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637006905 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637006906 DNA binding residues [nucleotide binding] 452637006907 Domain of unknown function (DUF377); Region: DUF377; pfam04041 452637006908 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 452637006909 active site 452637006910 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 452637006911 putative active cleft [active] 452637006912 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 452637006913 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 452637006914 catalytic domain interface [polypeptide binding]; other site 452637006915 putative homodimer interface [polypeptide binding]; other site 452637006916 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 452637006917 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 452637006918 substrate binding site [chemical binding]; other site 452637006919 ATP binding site [chemical binding]; other site 452637006920 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 452637006921 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 452637006922 catalytic domain interface [polypeptide binding]; other site 452637006923 putative homodimer interface [polypeptide binding]; other site 452637006924 Domain of unknown function (DUF377); Region: DUF377; pfam04041 452637006925 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 452637006926 active site 452637006927 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 452637006928 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 452637006929 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 452637006930 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 452637006931 MFS/sugar transport protein; Region: MFS_2; pfam13347 452637006932 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452637006933 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637006934 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637006935 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 452637006936 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637006937 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 452637006938 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]; Region: RPN7; COG5187 452637006939 Family description; Region: VCBS; pfam13517 452637006940 Family description; Region: VCBS; pfam13517 452637006941 Family description; Region: VCBS; pfam13517 452637006942 Family description; Region: VCBS; pfam13517 452637006943 Family description; Region: VCBS; pfam13517 452637006944 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637006945 Family description; Region: VCBS; pfam13517 452637006946 Family description; Region: VCBS; pfam13517 452637006947 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637006948 Family description; Region: VCBS; pfam13517 452637006949 Family description; Region: VCBS; pfam13517 452637006950 Family description; Region: VCBS; pfam13517 452637006951 Family description; Region: VCBS; pfam13517 452637006952 Family description; Region: VCBS; pfam13517 452637006953 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637006954 binding surface 452637006955 TPR motif; other site 452637006956 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637006957 binding surface 452637006958 TPR motif; other site 452637006959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637006960 TPR motif; other site 452637006961 TPR repeat; Region: TPR_11; pfam13414 452637006962 binding surface 452637006963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637006964 binding surface 452637006965 TPR motif; other site 452637006966 TPR repeat; Region: TPR_11; pfam13414 452637006967 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 452637006968 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 452637006969 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 452637006970 Family description; Region: VCBS; pfam13517 452637006971 Family description; Region: VCBS; pfam13517 452637006972 Family description; Region: VCBS; pfam13517 452637006973 Family description; Region: VCBS; pfam13517 452637006974 Family description; Region: VCBS; pfam13517 452637006975 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637006976 Family description; Region: VCBS; pfam13517 452637006977 Family description; Region: VCBS; pfam13517 452637006978 Family description; Region: VCBS; pfam13517 452637006979 Family description; Region: VCBS; pfam13517 452637006980 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 452637006981 active site 452637006982 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 452637006983 Family description; Region: VCBS; pfam13517 452637006984 Family description; Region: VCBS; pfam13517 452637006985 Family description; Region: VCBS; pfam13517 452637006986 Family description; Region: VCBS; pfam13517 452637006987 Family description; Region: VCBS; pfam13517 452637006988 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637006989 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 452637006990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637006991 active site 452637006992 phosphorylation site [posttranslational modification] 452637006993 intermolecular recognition site; other site 452637006994 dimerization interface [polypeptide binding]; other site 452637006995 LytTr DNA-binding domain; Region: LytTR; smart00850 452637006996 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 452637006997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637006998 active site 452637006999 phosphorylation site [posttranslational modification] 452637007000 intermolecular recognition site; other site 452637007001 dimerization interface [polypeptide binding]; other site 452637007002 LytTr DNA-binding domain; Region: LytTR; smart00850 452637007003 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452637007004 Histidine kinase; Region: His_kinase; pfam06580 452637007005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637007006 ATP binding site [chemical binding]; other site 452637007007 Mg2+ binding site [ion binding]; other site 452637007008 G-X-G motif; other site 452637007009 Family description; Region: VCBS; pfam13517 452637007010 Family description; Region: VCBS; pfam13517 452637007011 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637007012 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 452637007013 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 452637007014 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 452637007015 replicative DNA helicase; Region: DnaB; TIGR00665 452637007016 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 452637007017 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 452637007018 Walker A motif; other site 452637007019 ATP binding site [chemical binding]; other site 452637007020 Walker B motif; other site 452637007021 DNA binding loops [nucleotide binding] 452637007022 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 452637007023 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 452637007024 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 452637007025 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 452637007026 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 452637007027 Surface antigen; Region: Bac_surface_Ag; pfam01103 452637007028 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 452637007029 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 452637007030 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 452637007031 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 452637007032 trimer interface [polypeptide binding]; other site 452637007033 active site 452637007034 UDP-GlcNAc binding site [chemical binding]; other site 452637007035 lipid binding site [chemical binding]; lipid-binding site 452637007036 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 452637007037 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 452637007038 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 452637007039 active site 452637007040 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 452637007041 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 452637007042 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 452637007043 protein binding site [polypeptide binding]; other site 452637007044 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 452637007045 protein binding site [polypeptide binding]; other site 452637007046 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 452637007047 active site 452637007048 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 452637007049 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 452637007050 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 452637007051 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 452637007052 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 452637007053 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 452637007054 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 452637007055 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 452637007056 catalytic center binding site [active] 452637007057 ATP binding site [chemical binding]; other site 452637007058 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 452637007059 active site 452637007060 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 452637007061 dihydropteroate synthase; Region: DHPS; TIGR01496 452637007062 substrate binding pocket [chemical binding]; other site 452637007063 dimer interface [polypeptide binding]; other site 452637007064 inhibitor binding site; inhibition site 452637007065 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 452637007066 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 452637007067 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 452637007068 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 452637007069 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 452637007070 homodimer interface [polypeptide binding]; other site 452637007071 substrate-cofactor binding pocket; other site 452637007072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637007073 catalytic residue [active] 452637007074 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 452637007075 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 452637007076 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 452637007077 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 452637007078 23S rRNA binding site [nucleotide binding]; other site 452637007079 L21 binding site [polypeptide binding]; other site 452637007080 L13 binding site [polypeptide binding]; other site 452637007081 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 452637007082 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 452637007083 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 452637007084 dimer interface [polypeptide binding]; other site 452637007085 motif 1; other site 452637007086 active site 452637007087 motif 2; other site 452637007088 motif 3; other site 452637007089 GxxExxY protein; Region: GxxExxY; TIGR04256 452637007090 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 452637007091 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 452637007092 putative tRNA-binding site [nucleotide binding]; other site 452637007093 B3/4 domain; Region: B3_4; pfam03483 452637007094 tRNA synthetase B5 domain; Region: B5; pfam03484 452637007095 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 452637007096 motif 1; other site 452637007097 dimer interface [polypeptide binding]; other site 452637007098 active site 452637007099 motif 2; other site 452637007100 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 452637007101 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 452637007102 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 452637007103 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 452637007104 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 452637007105 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 452637007106 GatB domain; Region: GatB_Yqey; smart00845 452637007107 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637007108 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 452637007109 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 452637007110 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 452637007111 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 452637007112 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 452637007113 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 452637007114 metal binding site 2 [ion binding]; metal-binding site 452637007115 putative DNA binding helix; other site 452637007116 metal binding site 1 [ion binding]; metal-binding site 452637007117 dimer interface [polypeptide binding]; other site 452637007118 structural Zn2+ binding site [ion binding]; other site 452637007119 Verruc_Plancto-restricted protein; Region: Plancto_Ver_chp; TIGR04138 452637007120 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 452637007121 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 452637007122 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 452637007123 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 452637007124 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 452637007125 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 452637007126 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 452637007127 ATP-NAD kinase; Region: NAD_kinase; pfam01513 452637007128 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 452637007129 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 452637007130 RNA binding surface [nucleotide binding]; other site 452637007131 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 452637007132 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 452637007133 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cd08773 452637007134 DNA binding site [nucleotide binding] 452637007135 catalytic residue [active] 452637007136 H2TH interface [polypeptide binding]; other site 452637007137 putative catalytic residues [active] 452637007138 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 452637007139 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 452637007140 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 452637007141 active site 452637007142 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 452637007143 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 452637007144 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 452637007145 nudix motif; other site 452637007146 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 452637007147 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 452637007148 active site 452637007149 metal binding site [ion binding]; metal-binding site 452637007150 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 452637007151 Domain of unknown function (DUF386); Region: DUF386; cl01047 452637007152 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 452637007153 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 452637007154 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 452637007155 putative dimer interface [polypeptide binding]; other site 452637007156 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 452637007157 homodimer interface [polypeptide binding]; other site 452637007158 chemical substrate binding site [chemical binding]; other site 452637007159 oligomer interface [polypeptide binding]; other site 452637007160 metal binding site [ion binding]; metal-binding site 452637007161 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 452637007162 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 452637007163 MPT binding site; other site 452637007164 trimer interface [polypeptide binding]; other site 452637007165 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 452637007166 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 452637007167 active site 452637007168 HIGH motif; other site 452637007169 nucleotide binding site [chemical binding]; other site 452637007170 active site 452637007171 KMSKS motif; other site 452637007172 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 452637007173 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 452637007174 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452637007175 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 452637007176 dimerization interface [polypeptide binding]; other site 452637007177 substrate binding pocket [chemical binding]; other site 452637007178 Nitronate monooxygenase; Region: NMO; pfam03060 452637007179 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 452637007180 FMN binding site [chemical binding]; other site 452637007181 substrate binding site [chemical binding]; other site 452637007182 putative catalytic residue [active] 452637007183 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 452637007184 nudix motif; other site 452637007185 Oxygen tolerance; Region: BatD; pfam13584 452637007186 von Willebrand factor type A domain; Region: VWA_2; pfam13519 452637007187 metal ion-dependent adhesion site (MIDAS); other site 452637007188 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 452637007189 metal ion-dependent adhesion site (MIDAS); other site 452637007190 Protein of unknown function DUF58; Region: DUF58; pfam01882 452637007191 MoxR-like ATPases [General function prediction only]; Region: COG0714 452637007192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637007193 Walker A motif; other site 452637007194 ATP binding site [chemical binding]; other site 452637007195 Walker B motif; other site 452637007196 arginine finger; other site 452637007197 RF-1 domain; Region: RF-1; pfam00472 452637007198 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 452637007199 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 452637007200 MOSC domain; Region: MOSC; pfam03473 452637007201 Planctomycetes uncharacterized domain TIGR03067; Region: Planc_TIGR03067 452637007202 RmuC family; Region: RmuC; pfam02646 452637007203 Response regulator receiver domain; Region: Response_reg; pfam00072 452637007204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637007205 active site 452637007206 phosphorylation site [posttranslational modification] 452637007207 intermolecular recognition site; other site 452637007208 dimerization interface [polypeptide binding]; other site 452637007209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637007210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637007211 ATP binding site [chemical binding]; other site 452637007212 Mg2+ binding site [ion binding]; other site 452637007213 G-X-G motif; other site 452637007214 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 452637007215 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 452637007216 active site 452637007217 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637007218 dimer interface [polypeptide binding]; other site 452637007219 phosphorylation site [posttranslational modification] 452637007220 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637007221 ATP binding site [chemical binding]; other site 452637007222 Mg2+ binding site [ion binding]; other site 452637007223 G-X-G motif; other site 452637007224 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 452637007225 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 452637007226 Walker A/P-loop; other site 452637007227 ATP binding site [chemical binding]; other site 452637007228 Q-loop/lid; other site 452637007229 ABC transporter signature motif; other site 452637007230 Walker B; other site 452637007231 D-loop; other site 452637007232 H-loop/switch region; other site 452637007233 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 452637007234 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 452637007235 Survival protein SurE; Region: SurE; pfam01975 452637007236 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 452637007237 putative ligand binding site [chemical binding]; other site 452637007238 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 452637007239 putative transposase OrfB; Reviewed; Region: PHA02517 452637007240 DNA-binding interface [nucleotide binding]; DNA binding site 452637007241 Homeodomain-like domain; Region: HTH_32; pfam13565 452637007242 Integrase core domain; Region: rve; pfam00665 452637007243 Integrase core domain; Region: rve_3; cl15866 452637007244 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 452637007245 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 452637007246 RNase E interface [polypeptide binding]; other site 452637007247 trimer interface [polypeptide binding]; other site 452637007248 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 452637007249 RNase E interface [polypeptide binding]; other site 452637007250 trimer interface [polypeptide binding]; other site 452637007251 active site 452637007252 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 452637007253 putative nucleic acid binding region [nucleotide binding]; other site 452637007254 G-X-X-G motif; other site 452637007255 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 452637007256 RNA binding site [nucleotide binding]; other site 452637007257 domain interface; other site 452637007258 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 452637007259 16S/18S rRNA binding site [nucleotide binding]; other site 452637007260 S13e-L30e interaction site [polypeptide binding]; other site 452637007261 25S rRNA binding site [nucleotide binding]; other site 452637007262 Protein of unknown function (DUF721); Region: DUF721; pfam05258 452637007263 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 452637007264 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 452637007265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637007266 Walker A/P-loop; other site 452637007267 ATP binding site [chemical binding]; other site 452637007268 Q-loop/lid; other site 452637007269 ABC transporter signature motif; other site 452637007270 Walker B; other site 452637007271 D-loop; other site 452637007272 H-loop/switch region; other site 452637007273 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 452637007274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452637007275 dimer interface [polypeptide binding]; other site 452637007276 conserved gate region; other site 452637007277 putative PBP binding loops; other site 452637007278 ABC-ATPase subunit interface; other site 452637007279 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 452637007280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452637007281 dimer interface [polypeptide binding]; other site 452637007282 conserved gate region; other site 452637007283 putative PBP binding loops; other site 452637007284 ABC-ATPase subunit interface; other site 452637007285 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 452637007286 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 452637007287 DNA binding residues [nucleotide binding] 452637007288 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637007289 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637007290 dimer interface [polypeptide binding]; other site 452637007291 phosphorylation site [posttranslational modification] 452637007292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637007293 ATP binding site [chemical binding]; other site 452637007294 Mg2+ binding site [ion binding]; other site 452637007295 G-X-G motif; other site 452637007296 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452637007297 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452637007298 active site 452637007299 ATP binding site [chemical binding]; other site 452637007300 substrate binding site [chemical binding]; other site 452637007301 activation loop (A-loop); other site 452637007302 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 452637007303 putative transposase OrfB; Reviewed; Region: PHA02517 452637007304 DNA-binding interface [nucleotide binding]; DNA binding site 452637007305 Homeodomain-like domain; Region: HTH_32; pfam13565 452637007306 Integrase core domain; Region: rve; pfam00665 452637007307 Integrase core domain; Region: rve_3; cl15866 452637007308 serine O-acetyltransferase; Region: cysE; TIGR01172 452637007309 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 452637007310 trimer interface [polypeptide binding]; other site 452637007311 active site 452637007312 substrate binding site [chemical binding]; other site 452637007313 CoA binding site [chemical binding]; other site 452637007314 Rrf2 family protein; Region: rrf2_super; TIGR00738 452637007315 Transcriptional regulator; Region: Rrf2; pfam02082 452637007316 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 452637007317 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 452637007318 CysD dimerization site [polypeptide binding]; other site 452637007319 G1 box; other site 452637007320 putative GEF interaction site [polypeptide binding]; other site 452637007321 GTP/Mg2+ binding site [chemical binding]; other site 452637007322 Switch I region; other site 452637007323 G2 box; other site 452637007324 G3 box; other site 452637007325 Switch II region; other site 452637007326 G4 box; other site 452637007327 G5 box; other site 452637007328 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 452637007329 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 452637007330 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 452637007331 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 452637007332 Active Sites [active] 452637007333 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 452637007334 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 452637007335 Active Sites [active] 452637007336 sulfite reductase subunit beta; Provisional; Region: PRK13504 452637007337 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 452637007338 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 452637007339 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 452637007340 active site 452637007341 SAM binding site [chemical binding]; other site 452637007342 homodimer interface [polypeptide binding]; other site 452637007343 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 452637007344 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 452637007345 putative active site [active] 452637007346 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 452637007347 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 452637007348 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 452637007349 peptide binding site [polypeptide binding]; other site 452637007350 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 452637007351 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 452637007352 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 452637007353 PA/protease or protease-like domain interface [polypeptide binding]; other site 452637007354 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 452637007355 metal binding site [ion binding]; metal-binding site 452637007356 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 452637007357 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 452637007358 peptide binding site [polypeptide binding]; other site 452637007359 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 452637007360 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 452637007361 peptide binding site [polypeptide binding]; other site 452637007362 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 452637007363 homotrimer interaction site [polypeptide binding]; other site 452637007364 zinc binding site [ion binding]; other site 452637007365 CDP-binding sites; other site 452637007366 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 452637007367 substrate binding site; other site 452637007368 dimer interface; other site 452637007369 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 452637007370 active site 452637007371 dimer interface [polypeptide binding]; other site 452637007372 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 452637007373 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 452637007374 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 452637007375 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 452637007376 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 452637007377 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 452637007378 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 452637007379 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 452637007380 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 452637007381 folate binding site [chemical binding]; other site 452637007382 NADP+ binding site [chemical binding]; other site 452637007383 E3 Ubiquitin ligase; Region: GIDE; pfam12483 452637007384 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 452637007385 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 452637007386 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 452637007387 hexamer interface [polypeptide binding]; other site 452637007388 ligand binding site [chemical binding]; other site 452637007389 putative active site [active] 452637007390 NAD(P) binding site [chemical binding]; other site 452637007391 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 452637007392 active site 452637007393 recombination protein F; Reviewed; Region: recF; PRK00064 452637007394 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637007395 Walker A/P-loop; other site 452637007396 ATP binding site [chemical binding]; other site 452637007397 Q-loop/lid; other site 452637007398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637007399 ABC transporter signature motif; other site 452637007400 Walker B; other site 452637007401 D-loop; other site 452637007402 H-loop/switch region; other site 452637007403 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 452637007404 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 452637007405 active site 452637007406 putative DNA-binding cleft [nucleotide binding]; other site 452637007407 dimer interface [polypeptide binding]; other site 452637007408 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 452637007409 putative transporter; Provisional; Region: PRK11660 452637007410 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 452637007411 Sulfate transporter family; Region: Sulfate_transp; pfam00916 452637007412 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 452637007413 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 452637007414 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 452637007415 active site 452637007416 phosphorylation site [posttranslational modification] 452637007417 hydrogenase 4 subunit B; Validated; Region: PRK06521 452637007418 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452637007419 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 452637007420 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 452637007421 hydrogenase 4 subunit F; Validated; Region: PRK06458 452637007422 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452637007423 hydrogenase 4 subunit B; Validated; Region: PRK06521 452637007424 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452637007425 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 452637007426 NADH dehydrogenase; Region: NADHdh; cl00469 452637007427 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 452637007428 hydrogenase 4 subunit F; Validated; Region: PRK06458 452637007429 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452637007430 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 452637007431 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 452637007432 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 452637007433 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 452637007434 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 452637007435 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 452637007436 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 452637007437 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 452637007438 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 452637007439 4Fe-4S binding domain; Region: Fer4; pfam00037 452637007440 4Fe-4S binding domain; Region: Fer4; pfam00037 452637007441 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 452637007442 Transposase IS200 like; Region: Y1_Tnp; cl00848 452637007443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637007444 PAS fold; Region: PAS_3; pfam08447 452637007445 putative active site [active] 452637007446 heme pocket [chemical binding]; other site 452637007447 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 452637007448 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 452637007449 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637007450 putative active site [active] 452637007451 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 452637007452 dimer interface [polypeptide binding]; other site 452637007453 phosphorylation site [posttranslational modification] 452637007454 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637007455 ATP binding site [chemical binding]; other site 452637007456 Mg2+ binding site [ion binding]; other site 452637007457 G-X-G motif; other site 452637007458 Response regulator receiver domain; Region: Response_reg; pfam00072 452637007459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637007460 active site 452637007461 phosphorylation site [posttranslational modification] 452637007462 intermolecular recognition site; other site 452637007463 dimerization interface [polypeptide binding]; other site 452637007464 ferrochelatase; Reviewed; Region: hemH; PRK00035 452637007465 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 452637007466 C-terminal domain interface [polypeptide binding]; other site 452637007467 active site 452637007468 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 452637007469 active site 452637007470 N-terminal domain interface [polypeptide binding]; other site 452637007471 PAS domain S-box; Region: sensory_box; TIGR00229 452637007472 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 452637007473 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 452637007474 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637007475 putative active site [active] 452637007476 heme pocket [chemical binding]; other site 452637007477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 452637007478 dimer interface [polypeptide binding]; other site 452637007479 phosphorylation site [posttranslational modification] 452637007480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637007481 ATP binding site [chemical binding]; other site 452637007482 Mg2+ binding site [ion binding]; other site 452637007483 G-X-G motif; other site 452637007484 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637007485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637007486 active site 452637007487 phosphorylation site [posttranslational modification] 452637007488 intermolecular recognition site; other site 452637007489 dimerization interface [polypeptide binding]; other site 452637007490 phosphoglyceromutase; Provisional; Region: PRK05434 452637007491 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 452637007492 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 452637007493 active site 452637007494 nucleophile elbow; other site 452637007495 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 452637007496 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 452637007497 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 452637007498 dimer interface [polypeptide binding]; other site 452637007499 anticodon binding site; other site 452637007500 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 452637007501 homodimer interface [polypeptide binding]; other site 452637007502 motif 1; other site 452637007503 active site 452637007504 motif 2; other site 452637007505 GAD domain; Region: GAD; pfam02938 452637007506 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 452637007507 active site 452637007508 motif 3; other site 452637007509 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 452637007510 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 452637007511 Nitrogen regulatory protein P-II; Region: P-II; smart00938 452637007512 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 452637007513 Nitrogen regulatory protein P-II; Region: P-II; smart00938 452637007514 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 452637007515 Nitrogen regulatory protein P-II; Region: P-II; smart00938 452637007516 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 452637007517 Nitrogen regulatory protein P-II; Region: P-II; smart00938 452637007518 Cupin domain; Region: Cupin_2; pfam07883 452637007519 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 452637007520 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637007521 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 452637007522 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637007523 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637007524 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 452637007525 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 452637007526 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 452637007527 active site 452637007528 dimer interface [polypeptide binding]; other site 452637007529 motif 1; other site 452637007530 motif 2; other site 452637007531 motif 3; other site 452637007532 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 452637007533 anticodon binding site; other site 452637007534 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 452637007535 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452637007536 active site 452637007537 HIGH motif; other site 452637007538 nucleotide binding site [chemical binding]; other site 452637007539 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 452637007540 KMSKS motif; other site 452637007541 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 452637007542 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452637007543 Sel1-like repeats; Region: SEL1; smart00671 452637007544 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 452637007545 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 452637007546 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 452637007547 Zn binding sites [ion binding]; other site 452637007548 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 452637007549 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 452637007550 Zn binding sites [ion binding]; other site 452637007551 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 452637007552 dimer interface [polypeptide binding]; other site 452637007553 active site 452637007554 aspartate-rich active site metal binding site; other site 452637007555 allosteric magnesium binding site [ion binding]; other site 452637007556 Schiff base residues; other site 452637007557 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 452637007558 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 452637007559 SLBB domain; Region: SLBB; pfam10531 452637007560 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 452637007561 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 452637007562 quinone interaction residues [chemical binding]; other site 452637007563 active site 452637007564 catalytic residues [active] 452637007565 FMN binding site [chemical binding]; other site 452637007566 substrate binding site [chemical binding]; other site 452637007567 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 452637007568 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 452637007569 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637007570 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637007571 DNA binding residues [nucleotide binding] 452637007572 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637007573 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637007574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637007575 active site 452637007576 phosphorylation site [posttranslational modification] 452637007577 intermolecular recognition site; other site 452637007578 dimerization interface [polypeptide binding]; other site 452637007579 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637007580 DNA binding residues [nucleotide binding] 452637007581 dimerization interface [polypeptide binding]; other site 452637007582 Histidine kinase; Region: HisKA_3; pfam07730 452637007583 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 452637007584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637007585 ATP binding site [chemical binding]; other site 452637007586 Mg2+ binding site [ion binding]; other site 452637007587 G-X-G motif; other site 452637007588 Phosphate transporter family; Region: PHO4; pfam01384 452637007589 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 452637007590 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 452637007591 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 452637007592 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 452637007593 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 452637007594 active site 452637007595 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 452637007596 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 452637007597 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 452637007598 thiamine monophosphate kinase; Provisional; Region: PRK05731 452637007599 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 452637007600 ATP binding site [chemical binding]; other site 452637007601 dimerization interface [polypeptide binding]; other site 452637007602 CAAX protease self-immunity; Region: Abi; pfam02517 452637007603 dihydroorotase; Validated; Region: pyrC; PRK09357 452637007604 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 452637007605 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 452637007606 active site 452637007607 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 452637007608 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 452637007609 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 452637007610 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 452637007611 active site 452637007612 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 452637007613 catalytic triad [active] 452637007614 putative active site [active] 452637007615 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 452637007616 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 452637007617 Trp docking motif [polypeptide binding]; other site 452637007618 active site 452637007619 PQQ-like domain; Region: PQQ_2; pfam13360 452637007620 Immunoglobulin domain; Region: Ig; cd00096 452637007621 DEAD_2; Region: DEAD_2; pfam06733 452637007622 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 452637007623 Uncharacterized conserved protein [Function unknown]; Region: COG2928 452637007624 Immunoglobulin domain; Region: Ig; cl11960 452637007625 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 452637007626 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 452637007627 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 452637007628 catalytic loop [active] 452637007629 iron binding site [ion binding]; other site 452637007630 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 452637007631 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 452637007632 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 452637007633 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 452637007634 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 452637007635 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 452637007636 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 452637007637 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452637007638 Zn2+ binding site [ion binding]; other site 452637007639 Mg2+ binding site [ion binding]; other site 452637007640 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 452637007641 PhoH-like protein; Region: PhoH; pfam02562 452637007642 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 452637007643 nucleotide binding site/active site [active] 452637007644 HIT family signature motif; other site 452637007645 catalytic residue [active] 452637007646 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452637007647 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452637007648 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 452637007649 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 452637007650 dimer interface [polypeptide binding]; other site 452637007651 active site 452637007652 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 452637007653 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 452637007654 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 452637007655 active site 452637007656 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 452637007657 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 452637007658 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 452637007659 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 452637007660 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 452637007661 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 452637007662 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 452637007663 YCII-related domain; Region: YCII; cl00999 452637007664 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452637007665 Sel1-like repeats; Region: SEL1; smart00671 452637007666 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 452637007667 putative active site [active] 452637007668 putative metal binding site [ion binding]; other site 452637007669 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 452637007670 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 452637007671 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 452637007672 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 452637007673 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 452637007674 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452637007675 ATP binding site [chemical binding]; other site 452637007676 putative Mg++ binding site [ion binding]; other site 452637007677 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452637007678 nucleotide binding region [chemical binding]; other site 452637007679 ATP-binding site [chemical binding]; other site 452637007680 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 452637007681 active site 452637007682 phosphorylation site [posttranslational modification] 452637007683 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 452637007684 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 452637007685 Cl- selectivity filter; other site 452637007686 Cl- binding residues [ion binding]; other site 452637007687 pore gating glutamate residue; other site 452637007688 dimer interface [polypeptide binding]; other site 452637007689 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 452637007690 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 452637007691 PBP superfamily domain; Region: PBP_like_2; cl17296 452637007692 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 452637007693 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 452637007694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452637007695 dimer interface [polypeptide binding]; other site 452637007696 conserved gate region; other site 452637007697 putative PBP binding loops; other site 452637007698 ABC-ATPase subunit interface; other site 452637007699 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 452637007700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452637007701 dimer interface [polypeptide binding]; other site 452637007702 conserved gate region; other site 452637007703 putative PBP binding loops; other site 452637007704 ABC-ATPase subunit interface; other site 452637007705 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 452637007706 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 452637007707 Walker A/P-loop; other site 452637007708 ATP binding site [chemical binding]; other site 452637007709 Q-loop/lid; other site 452637007710 ABC transporter signature motif; other site 452637007711 Walker B; other site 452637007712 D-loop; other site 452637007713 H-loop/switch region; other site 452637007714 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 452637007715 PhoU domain; Region: PhoU; pfam01895 452637007716 PhoU domain; Region: PhoU; pfam01895 452637007717 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452637007718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637007719 active site 452637007720 phosphorylation site [posttranslational modification] 452637007721 intermolecular recognition site; other site 452637007722 dimerization interface [polypeptide binding]; other site 452637007723 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452637007724 DNA binding site [nucleotide binding] 452637007725 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 452637007726 PAS domain; Region: PAS; smart00091 452637007727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637007728 dimer interface [polypeptide binding]; other site 452637007729 phosphorylation site [posttranslational modification] 452637007730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637007731 ATP binding site [chemical binding]; other site 452637007732 Mg2+ binding site [ion binding]; other site 452637007733 G-X-G motif; other site 452637007734 Phosphate transporter family; Region: PHO4; pfam01384 452637007735 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 452637007736 Uncharacterized conserved protein [Function unknown]; Region: COG1434 452637007737 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 452637007738 putative active site [active] 452637007739 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 452637007740 putative catalytic site [active] 452637007741 putative metal binding site [ion binding]; other site 452637007742 putative phosphate binding site [ion binding]; other site 452637007743 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 452637007744 substrate binding site [chemical binding]; other site 452637007745 active site 452637007746 catalytic residues [active] 452637007747 heterodimer interface [polypeptide binding]; other site 452637007748 Response regulator receiver domain; Region: Response_reg; pfam00072 452637007749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637007750 active site 452637007751 phosphorylation site [posttranslational modification] 452637007752 intermolecular recognition site; other site 452637007753 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 452637007754 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 452637007755 metal binding site [ion binding]; metal-binding site 452637007756 active site 452637007757 I-site; other site 452637007758 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 452637007759 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 452637007760 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 452637007761 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 452637007762 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 452637007763 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 452637007764 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 452637007765 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 452637007766 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 452637007767 active site 452637007768 HIGH motif; other site 452637007769 KMSK motif region; other site 452637007770 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 452637007771 tRNA binding surface [nucleotide binding]; other site 452637007772 anticodon binding site; other site 452637007773 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 452637007774 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 452637007775 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 452637007776 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 452637007777 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 452637007778 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637007779 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637007780 DNA binding residues [nucleotide binding] 452637007781 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 452637007782 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 452637007783 putative RNA binding site [nucleotide binding]; other site 452637007784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637007785 S-adenosylmethionine binding site [chemical binding]; other site 452637007786 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 452637007787 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452637007788 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 452637007789 active site 452637007790 metal binding site [ion binding]; metal-binding site 452637007791 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 452637007792 active site clefts [active] 452637007793 zinc binding site [ion binding]; other site 452637007794 dimer interface [polypeptide binding]; other site 452637007795 elongation factor P; Validated; Region: PRK00529 452637007796 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 452637007797 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 452637007798 RNA binding site [nucleotide binding]; other site 452637007799 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 452637007800 RNA binding site [nucleotide binding]; other site 452637007801 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 452637007802 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 452637007803 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 452637007804 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 452637007805 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 452637007806 active site 452637007807 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 452637007808 Protein of unknown function (DUF971); Region: DUF971; pfam06155 452637007809 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 452637007810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452637007811 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 452637007812 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 452637007813 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 452637007814 Cytochrome c; Region: Cytochrom_C; cl11414 452637007815 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 452637007816 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 452637007817 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 452637007818 FAD binding domain; Region: FAD_binding_4; pfam01565 452637007819 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 452637007820 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 452637007821 active site 452637007822 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 452637007823 Peptidase family M23; Region: Peptidase_M23; pfam01551 452637007824 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 452637007825 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 452637007826 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 452637007827 heme-binding residues [chemical binding]; other site 452637007828 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 452637007829 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 452637007830 heme-binding residues [chemical binding]; other site 452637007831 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 452637007832 heme-binding residues [chemical binding]; other site 452637007833 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 452637007834 PAS fold; Region: PAS_4; pfam08448 452637007835 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637007836 putative active site [active] 452637007837 heme pocket [chemical binding]; other site 452637007838 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637007839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637007840 ATP binding site [chemical binding]; other site 452637007841 Mg2+ binding site [ion binding]; other site 452637007842 G-X-G motif; other site 452637007843 Two component regulator propeller; Region: Reg_prop; pfam07494 452637007844 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 452637007845 PAS domain; Region: PAS; smart00091 452637007846 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 452637007847 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637007848 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 452637007849 putative active site [active] 452637007850 heme pocket [chemical binding]; other site 452637007851 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637007852 heme pocket [chemical binding]; other site 452637007853 putative active site [active] 452637007854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637007855 ATP binding site [chemical binding]; other site 452637007856 Mg2+ binding site [ion binding]; other site 452637007857 G-X-G motif; other site 452637007858 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 452637007859 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 452637007860 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 452637007861 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 452637007862 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 452637007863 Na binding site [ion binding]; other site 452637007864 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 452637007865 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 452637007866 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 452637007867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637007868 TPR repeat; Region: TPR_11; pfam13414 452637007869 binding surface 452637007870 TPR motif; other site 452637007871 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 452637007872 active site 452637007873 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 452637007874 30S subunit binding site; other site 452637007875 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452637007876 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452637007877 active site 452637007878 catalytic tetrad [active] 452637007879 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 452637007880 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 452637007881 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 452637007882 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 452637007883 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 452637007884 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 452637007885 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452637007886 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452637007887 active site 452637007888 catalytic tetrad [active] 452637007889 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637007890 PAS fold; Region: PAS_3; pfam08447 452637007891 putative active site [active] 452637007892 heme pocket [chemical binding]; other site 452637007893 MraZ protein; Region: MraZ; pfam02381 452637007894 cell division protein MraZ; Reviewed; Region: PRK00326 452637007895 MraZ protein; Region: MraZ; pfam02381 452637007896 MraW methylase family; Region: Methyltransf_5; cl17771 452637007897 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 452637007898 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 452637007899 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 452637007900 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 452637007901 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 452637007902 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 452637007903 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 452637007904 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 452637007905 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 452637007906 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 452637007907 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 452637007908 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 452637007909 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 452637007910 Mg++ binding site [ion binding]; other site 452637007911 putative catalytic motif [active] 452637007912 putative substrate binding site [chemical binding]; other site 452637007913 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 452637007914 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 452637007915 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 452637007916 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 452637007917 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 452637007918 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 452637007919 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 452637007920 active site 452637007921 homodimer interface [polypeptide binding]; other site 452637007922 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 452637007923 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 452637007924 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 452637007925 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 452637007926 FAD binding domain; Region: FAD_binding_4; pfam01565 452637007927 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 452637007928 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 452637007929 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 452637007930 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452637007931 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 452637007932 cell division protein FtsA; Region: ftsA; TIGR01174 452637007933 Cell division protein FtsA; Region: FtsA; smart00842 452637007934 Cell division protein FtsA; Region: FtsA; pfam14450 452637007935 cell division protein FtsZ; Region: ftsZ; TIGR00065 452637007936 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 452637007937 nucleotide binding site [chemical binding]; other site 452637007938 SulA interaction site; other site 452637007939 Sigma 54 modulation protein / S30EA ribosomal protein; Region: Ribosomal_S30AE; pfam02482 452637007940 30S subunit binding site; other site 452637007941 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 452637007942 classical (c) SDRs; Region: SDR_c; cd05233 452637007943 NAD(P) binding site [chemical binding]; other site 452637007944 active site 452637007945 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 452637007946 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 452637007947 active site 452637007948 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 452637007949 putative active site [active] 452637007950 Zn binding site [ion binding]; other site 452637007951 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 452637007952 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 452637007953 active site 452637007954 HIGH motif; other site 452637007955 KMSKS motif; other site 452637007956 Gram-negative bacterial tonB protein; Region: TonB; cl10048 452637007957 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 452637007958 4Fe-4S binding domain; Region: Fer4_5; pfam12801 452637007959 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 452637007960 ferredoxin-type protein; Provisional; Region: PRK10194 452637007961 Uncharacterized conserved protein [Function unknown]; Region: COG2006 452637007962 Domain of unknown function (DUF362); Region: DUF362; pfam04015 452637007963 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 452637007964 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 452637007965 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 452637007966 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 452637007967 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452637007968 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452637007969 active site 452637007970 ATP binding site [chemical binding]; other site 452637007971 substrate binding site [chemical binding]; other site 452637007972 activation loop (A-loop); other site 452637007973 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 452637007974 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 452637007975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637007976 S-adenosylmethionine binding site [chemical binding]; other site 452637007977 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 452637007978 IHF dimer interface [polypeptide binding]; other site 452637007979 IHF - DNA interface [nucleotide binding]; other site 452637007980 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 452637007981 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 452637007982 dimer interface [polypeptide binding]; other site 452637007983 motif 1; other site 452637007984 active site 452637007985 motif 2; other site 452637007986 motif 3; other site 452637007987 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 452637007988 anticodon binding site; other site 452637007989 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 452637007990 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 452637007991 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 452637007992 active site 452637007993 catalytic motif [active] 452637007994 Zn binding site [ion binding]; other site 452637007995 2-amino-3-ketobutyrate coenzyme A ligase; Provisional; Region: PRK06939 452637007996 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 452637007997 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452637007998 catalytic residue [active] 452637007999 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 452637008000 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 452637008001 NAD(P) binding site [chemical binding]; other site 452637008002 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 452637008003 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 452637008004 DNA binding site [nucleotide binding] 452637008005 active site 452637008006 RNB domain; Region: RNB; pfam00773 452637008007 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 452637008008 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 452637008009 RNA binding site [nucleotide binding]; other site 452637008010 glycogen synthase; Provisional; Region: glgA; PRK00654 452637008011 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 452637008012 ADP-binding pocket [chemical binding]; other site 452637008013 homodimer interface [polypeptide binding]; other site 452637008014 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 452637008015 DNA photolyase; Region: DNA_photolyase; pfam00875 452637008016 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 452637008017 TIGR01777 family protein; Region: yfcH 452637008018 putative NAD(P) binding site [chemical binding]; other site 452637008019 putative active site [active] 452637008020 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 452637008021 active site 452637008022 multimer interface [polypeptide binding]; other site 452637008023 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 452637008024 active site 452637008025 catalytic triad [active] 452637008026 oxyanion hole [active] 452637008027 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 452637008028 putative dehydratase; Provisional; Region: PRK08211 452637008029 Dehydratase family; Region: ILVD_EDD; cl00340 452637008030 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 452637008031 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 452637008032 dimer interface [polypeptide binding]; other site 452637008033 NADP binding site [chemical binding]; other site 452637008034 catalytic residues [active] 452637008035 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 452637008036 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 452637008037 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637008038 D-galactonate transporter; Region: 2A0114; TIGR00893 452637008039 putative substrate translocation pore; other site 452637008040 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 452637008041 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 452637008042 DRTGG domain; Region: DRTGG; pfam07085 452637008043 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 452637008044 DHH family; Region: DHH; pfam01368 452637008045 DHHA2 domain; Region: DHHA2; pfam02833 452637008046 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 452637008047 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 452637008048 homodimer interface [polypeptide binding]; other site 452637008049 substrate-cofactor binding pocket; other site 452637008050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637008051 catalytic residue [active] 452637008052 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 452637008053 UvrB/uvrC motif; Region: UVR; pfam02151 452637008054 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 452637008055 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 452637008056 ADP binding site [chemical binding]; other site 452637008057 phosphagen binding site; other site 452637008058 substrate specificity loop; other site 452637008059 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 452637008060 Clp amino terminal domain; Region: Clp_N; pfam02861 452637008061 Clp amino terminal domain; Region: Clp_N; pfam02861 452637008062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637008063 Walker A motif; other site 452637008064 ATP binding site [chemical binding]; other site 452637008065 Walker B motif; other site 452637008066 arginine finger; other site 452637008067 UvrB/uvrC motif; Region: UVR; pfam02151 452637008068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637008069 Walker A motif; other site 452637008070 ATP binding site [chemical binding]; other site 452637008071 Walker B motif; other site 452637008072 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 452637008073 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452637008074 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452637008075 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 452637008076 dimerization interface [polypeptide binding]; other site 452637008077 substrate binding pocket [chemical binding]; other site 452637008078 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 452637008079 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 452637008080 substrate binding site [chemical binding]; other site 452637008081 ligand binding site [chemical binding]; other site 452637008082 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 452637008083 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 452637008084 substrate binding site [chemical binding]; other site 452637008085 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 452637008086 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 452637008087 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 452637008088 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 452637008089 active site 452637008090 HIGH motif; other site 452637008091 dimer interface [polypeptide binding]; other site 452637008092 KMSKS motif; other site 452637008093 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 452637008094 RNA binding surface [nucleotide binding]; other site 452637008095 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 452637008096 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 452637008097 aconitate hydratase; Validated; Region: PRK09277 452637008098 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 452637008099 substrate binding site [chemical binding]; other site 452637008100 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 452637008101 ligand binding site [chemical binding]; other site 452637008102 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 452637008103 substrate binding site [chemical binding]; other site 452637008104 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 452637008105 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 452637008106 anti sigma factor interaction site; other site 452637008107 regulatory phosphorylation site [posttranslational modification]; other site 452637008108 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452637008109 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452637008110 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 452637008111 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452637008112 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 452637008113 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 452637008114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637008115 catalytic residue [active] 452637008116 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 452637008117 four helix bundle protein; Region: TIGR02436 452637008118 hypothetical protein; Provisional; Region: PRK11820 452637008119 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 452637008120 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 452637008121 lipoprotein signal peptidase; Provisional; Region: PRK14787 452637008122 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 452637008123 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 452637008124 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 452637008125 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452637008126 active site 452637008127 HIGH motif; other site 452637008128 nucleotide binding site [chemical binding]; other site 452637008129 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 452637008130 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452637008131 KMSKS motif; other site 452637008132 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 452637008133 tRNA binding surface [nucleotide binding]; other site 452637008134 anticodon binding site; other site 452637008135 protoporphyrinogen oxidase; Region: PLN02576 452637008136 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 452637008137 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 452637008138 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 452637008139 substrate binding site [chemical binding]; other site 452637008140 active site 452637008141 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 452637008142 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 452637008143 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 452637008144 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 452637008145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 452637008146 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 452637008147 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 452637008148 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 452637008149 G1 box; other site 452637008150 putative GEF interaction site [polypeptide binding]; other site 452637008151 GTP/Mg2+ binding site [chemical binding]; other site 452637008152 Switch I region; other site 452637008153 G2 box; other site 452637008154 G3 box; other site 452637008155 Switch II region; other site 452637008156 G4 box; other site 452637008157 G5 box; other site 452637008158 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 452637008159 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 452637008160 PUA domain; Region: PUA; cl00607 452637008161 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 452637008162 putative RNA binding site [nucleotide binding]; other site 452637008163 Methyltransferase domain; Region: Methyltransf_26; pfam13659 452637008164 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 452637008165 enolase; Provisional; Region: eno; PRK00077 452637008166 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 452637008167 dimer interface [polypeptide binding]; other site 452637008168 metal binding site [ion binding]; metal-binding site 452637008169 substrate binding pocket [chemical binding]; other site 452637008170 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 452637008171 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452637008172 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452637008173 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452637008174 Response regulator receiver domain; Region: Response_reg; pfam00072 452637008175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637008176 active site 452637008177 phosphorylation site [posttranslational modification] 452637008178 intermolecular recognition site; other site 452637008179 dimerization interface [polypeptide binding]; other site 452637008180 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 452637008181 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637008182 Walker A/P-loop; other site 452637008183 ATP binding site [chemical binding]; other site 452637008184 Q-loop/lid; other site 452637008185 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 452637008186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637008187 Walker A/P-loop; other site 452637008188 ATP binding site [chemical binding]; other site 452637008189 Q-loop/lid; other site 452637008190 ABC transporter signature motif; other site 452637008191 Walker B; other site 452637008192 D-loop; other site 452637008193 H-loop/switch region; other site 452637008194 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637008195 Walker A/P-loop; other site 452637008196 ATP binding site [chemical binding]; other site 452637008197 Q-loop/lid; other site 452637008198 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 452637008199 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 452637008200 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637008201 Walker A/P-loop; other site 452637008202 ATP binding site [chemical binding]; other site 452637008203 Q-loop/lid; other site 452637008204 ABC transporter signature motif; other site 452637008205 Walker B; other site 452637008206 D-loop; other site 452637008207 H-loop/switch region; other site 452637008208 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 452637008209 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 452637008210 putative ADP-binding pocket [chemical binding]; other site 452637008211 Membrane protein of unknown function; Region: DUF360; pfam04020 452637008212 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 452637008213 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452637008214 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 452637008215 HDOD domain; Region: HDOD; pfam08668 452637008216 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 452637008217 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 452637008218 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 452637008219 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 452637008220 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 452637008221 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 452637008222 SmpB-tmRNA interface; other site 452637008223 homoserine kinase; Provisional; Region: PRK01212 452637008224 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 452637008225 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 452637008226 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 452637008227 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452637008228 Walker A/P-loop; other site 452637008229 ATP binding site [chemical binding]; other site 452637008230 Q-loop/lid; other site 452637008231 ABC transporter signature motif; other site 452637008232 Walker B; other site 452637008233 D-loop; other site 452637008234 H-loop/switch region; other site 452637008235 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 452637008236 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 452637008237 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 452637008238 Walker A/P-loop; other site 452637008239 ATP binding site [chemical binding]; other site 452637008240 Q-loop/lid; other site 452637008241 ABC transporter signature motif; other site 452637008242 Walker B; other site 452637008243 D-loop; other site 452637008244 H-loop/switch region; other site 452637008245 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 452637008246 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 452637008247 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 452637008248 putative active site [active] 452637008249 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 452637008250 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 452637008251 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452637008252 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 452637008253 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 452637008254 putative acyl-acceptor binding pocket; other site 452637008255 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 452637008256 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 452637008257 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 452637008258 putative active site [active] 452637008259 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 452637008260 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 452637008261 putative active site [active] 452637008262 seryl-tRNA synthetase; Provisional; Region: PRK05431 452637008263 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 452637008264 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 452637008265 dimer interface [polypeptide binding]; other site 452637008266 active site 452637008267 motif 1; other site 452637008268 motif 2; other site 452637008269 motif 3; other site 452637008270 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 452637008271 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 452637008272 Ligand Binding Site [chemical binding]; other site 452637008273 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 452637008274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637008275 Walker A motif; other site 452637008276 ATP binding site [chemical binding]; other site 452637008277 Walker B motif; other site 452637008278 arginine finger; other site 452637008279 Peptidase family M41; Region: Peptidase_M41; pfam01434 452637008280 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 452637008281 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 452637008282 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 452637008283 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 452637008284 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 452637008285 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 452637008286 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 452637008287 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 452637008288 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 452637008289 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 452637008290 active site 452637008291 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 452637008292 dimer interface [polypeptide binding]; other site 452637008293 substrate binding site [chemical binding]; other site 452637008294 catalytic residues [active] 452637008295 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 452637008296 trigger factor; Provisional; Region: tig; PRK01490 452637008297 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 452637008298 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 452637008299 Clp protease; Region: CLP_protease; pfam00574 452637008300 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 452637008301 oligomer interface [polypeptide binding]; other site 452637008302 active site residues [active] 452637008303 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 452637008304 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 452637008305 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 452637008306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637008307 Walker A motif; other site 452637008308 ATP binding site [chemical binding]; other site 452637008309 Walker B motif; other site 452637008310 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 452637008311 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 452637008312 putative active cleft [active] 452637008313 dimerization interface [polypeptide binding]; other site 452637008314 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 452637008315 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 452637008316 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 452637008317 oligomer interface [polypeptide binding]; other site 452637008318 active site 452637008319 metal binding site [ion binding]; metal-binding site 452637008320 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 452637008321 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 452637008322 catalytic residues [active] 452637008323 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 452637008324 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 452637008325 NAD binding site [chemical binding]; other site 452637008326 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 452637008327 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452637008328 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 452637008329 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 452637008330 Bacterial sugar transferase; Region: Bac_transf; pfam02397 452637008331 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 452637008332 putative glycosyl transferase; Provisional; Region: PRK10307 452637008333 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 452637008334 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 452637008335 putative metal binding site; other site 452637008336 O-Antigen ligase; Region: Wzy_C; pfam04932 452637008337 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 452637008338 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637008339 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 452637008340 putative ADP-binding pocket [chemical binding]; other site 452637008341 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 452637008342 putative trimer interface [polypeptide binding]; other site 452637008343 putative active site [active] 452637008344 putative substrate binding site [chemical binding]; other site 452637008345 putative CoA binding site [chemical binding]; other site 452637008346 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637008347 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452637008348 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 452637008349 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452637008350 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452637008351 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637008352 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 452637008353 putative ADP-binding pocket [chemical binding]; other site 452637008354 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452637008355 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452637008356 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637008357 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 452637008358 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 452637008359 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452637008360 active site 452637008361 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 452637008362 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 452637008363 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 452637008364 active site 452637008365 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637008366 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452637008367 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 452637008368 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452637008369 active site 452637008370 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 452637008371 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 452637008372 homodimer interface [polypeptide binding]; other site 452637008373 active site 452637008374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637008375 S-adenosylmethionine binding site [chemical binding]; other site 452637008376 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 452637008377 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 452637008378 Walker A/P-loop; other site 452637008379 ATP binding site [chemical binding]; other site 452637008380 Q-loop/lid; other site 452637008381 ABC transporter signature motif; other site 452637008382 Walker B; other site 452637008383 D-loop; other site 452637008384 H-loop/switch region; other site 452637008385 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 452637008386 putative carbohydrate binding site [chemical binding]; other site 452637008387 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 452637008388 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 452637008389 WxcM-like, C-terminal; Region: FdtA; pfam05523 452637008390 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637008391 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452637008392 DJ-1 family protein; Region: not_thiJ; TIGR01383 452637008393 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 452637008394 conserved cys residue [active] 452637008395 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452637008396 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452637008397 NAD(P) binding site [chemical binding]; other site 452637008398 active site 452637008399 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 452637008400 recombination protein RecR; Reviewed; Region: recR; PRK00076 452637008401 RecR protein; Region: RecR; pfam02132 452637008402 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 452637008403 putative active site [active] 452637008404 putative metal-binding site [ion binding]; other site 452637008405 tetramer interface [polypeptide binding]; other site 452637008406 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 452637008407 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 452637008408 TPP-binding site; other site 452637008409 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 452637008410 PYR/PP interface [polypeptide binding]; other site 452637008411 dimer interface [polypeptide binding]; other site 452637008412 TPP binding site [chemical binding]; other site 452637008413 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 452637008414 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 452637008415 Peptidase family M48; Region: Peptidase_M48; pfam01435 452637008416 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 452637008417 putative catalytic site [active] 452637008418 putative metal binding site [ion binding]; other site 452637008419 putative phosphate binding site [ion binding]; other site 452637008420 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 452637008421 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452637008422 FeS/SAM binding site; other site 452637008423 HemN C-terminal domain; Region: HemN_C; pfam06969 452637008424 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 452637008425 Peptidase family M23; Region: Peptidase_M23; pfam01551 452637008426 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452637008427 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637008428 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637008429 DNA binding residues [nucleotide binding] 452637008430 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637008431 TPR motif; other site 452637008432 binding surface 452637008433 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 452637008434 metal binding site 2 [ion binding]; metal-binding site 452637008435 putative DNA binding helix; other site 452637008436 metal binding site 1 [ion binding]; metal-binding site 452637008437 dimer interface [polypeptide binding]; other site 452637008438 structural Zn2+ binding site [ion binding]; other site 452637008439 primosome assembly protein PriA; Validated; Region: PRK05580 452637008440 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452637008441 ATP binding site [chemical binding]; other site 452637008442 putative Mg++ binding site [ion binding]; other site 452637008443 helicase superfamily c-terminal domain; Region: HELICc; smart00490 452637008444 N-acetylglutamate synthase; Validated; Region: PRK05279 452637008445 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 452637008446 nucleotide binding site [chemical binding]; other site 452637008447 substrate binding site [chemical binding]; other site 452637008448 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452637008449 Coenzyme A binding pocket [chemical binding]; other site 452637008450 prolyl-tRNA synthetase; Provisional; Region: PRK09194 452637008451 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 452637008452 motif 1; other site 452637008453 dimer interface [polypeptide binding]; other site 452637008454 active site 452637008455 motif 2; other site 452637008456 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 452637008457 putative deacylase active site [active] 452637008458 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 452637008459 active site 452637008460 motif 3; other site 452637008461 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 452637008462 anticodon binding site; other site 452637008463 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 452637008464 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like2_exo; cd05785 452637008465 DNA polymerase type-B family; Region: POLBc; smart00486 452637008466 active site 452637008467 catalytic site [active] 452637008468 substrate binding site [chemical binding]; other site 452637008469 DNA polymerase family B; Region: DNA_pol_B; pfam00136 452637008470 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 452637008471 active site 452637008472 metal-binding site 452637008473 P-loop containing region of AAA domain; Region: AAA_29; cl17516 452637008474 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 452637008475 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 452637008476 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 452637008477 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 452637008478 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 452637008479 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 452637008480 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 452637008481 catalytic loop [active] 452637008482 iron binding site [ion binding]; other site 452637008483 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 452637008484 Adenylosuccinate synthetase; Region: Adenylsucc_synt; pfam00709 452637008485 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 452637008486 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 452637008487 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 452637008488 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 452637008489 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 452637008490 active site 452637008491 O-succinylbenzoate synthase; Provisional; Region: PRK02714 452637008492 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 452637008493 active site 452637008494 O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445 452637008495 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452637008496 acyl-activating enzyme (AAE) consensus motif; other site 452637008497 AMP binding site [chemical binding]; other site 452637008498 active site 452637008499 CoA binding site [chemical binding]; other site 452637008500 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 452637008501 active site 452637008502 hypothetical protein; Provisional; Region: PRK08609 452637008503 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 452637008504 active site 452637008505 primer binding site [nucleotide binding]; other site 452637008506 NTP binding site [chemical binding]; other site 452637008507 metal binding triad [ion binding]; metal-binding site 452637008508 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 452637008509 active site 452637008510 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 452637008511 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 452637008512 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 452637008513 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 452637008514 NusA N-terminal domain; Region: NusA_N; pfam08529 452637008515 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 452637008516 RNA binding site [nucleotide binding]; other site 452637008517 homodimer interface [polypeptide binding]; other site 452637008518 NusA-like KH domain; Region: KH_5; pfam13184 452637008519 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 452637008520 G-X-X-G motif; other site 452637008521 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 452637008522 translation initiation factor IF-2; Region: IF-2; TIGR00487 452637008523 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 452637008524 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 452637008525 G1 box; other site 452637008526 putative GEF interaction site [polypeptide binding]; other site 452637008527 GTP/Mg2+ binding site [chemical binding]; other site 452637008528 Switch I region; other site 452637008529 G2 box; other site 452637008530 G3 box; other site 452637008531 Switch II region; other site 452637008532 G4 box; other site 452637008533 G5 box; other site 452637008534 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 452637008535 Translation-initiation factor 2; Region: IF-2; pfam11987 452637008536 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 452637008537 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 452637008538 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 452637008539 DHH family; Region: DHH; pfam01368 452637008540 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 452637008541 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 452637008542 RNA binding site [nucleotide binding]; other site 452637008543 active site 452637008544 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 452637008545 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 452637008546 active site 452637008547 Riboflavin kinase; Region: Flavokinase; smart00904 452637008548 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 452637008549 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637008550 Walker A/P-loop; other site 452637008551 ATP binding site [chemical binding]; other site 452637008552 Q-loop/lid; other site 452637008553 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 452637008554 ABC transporter signature motif; other site 452637008555 Walker B; other site 452637008556 D-loop; other site 452637008557 H-loop/switch region; other site 452637008558 Trehalose utilisation; Region: ThuA; pfam06283 452637008559 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 452637008560 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 452637008561 CHRD domain; Region: CHRD; cl06473 452637008562 CHRD domain; Region: CHRD; pfam07452 452637008563 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 452637008564 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 452637008565 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 452637008566 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 452637008567 putative active site [active] 452637008568 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 452637008569 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 452637008570 substrate binding site [chemical binding]; other site 452637008571 glutamase interaction surface [polypeptide binding]; other site 452637008572 transcription termination factor Rho; Provisional; Region: PRK12608 452637008573 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452637008574 Walker A motif; other site 452637008575 ATP binding site [chemical binding]; other site 452637008576 Walker B motif; other site 452637008577 acetyl-CoA synthetase; Provisional; Region: PRK00174 452637008578 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 452637008579 active site 452637008580 CoA binding site [chemical binding]; other site 452637008581 acyl-activating enzyme (AAE) consensus motif; other site 452637008582 AMP binding site [chemical binding]; other site 452637008583 acetate binding site [chemical binding]; other site 452637008584 Response regulator receiver domain; Region: Response_reg; pfam00072 452637008585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637008586 active site 452637008587 phosphorylation site [posttranslational modification] 452637008588 intermolecular recognition site; other site 452637008589 dimerization interface [polypeptide binding]; other site 452637008590 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 452637008591 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452637008592 Zn binding site [ion binding]; other site 452637008593 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 452637008594 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452637008595 Zn binding site [ion binding]; other site 452637008596 Response regulator receiver domain; Region: Response_reg; pfam00072 452637008597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637008598 active site 452637008599 phosphorylation site [posttranslational modification] 452637008600 intermolecular recognition site; other site 452637008601 dimerization interface [polypeptide binding]; other site 452637008602 Response regulator receiver domain; Region: Response_reg; pfam00072 452637008603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637008604 active site 452637008605 phosphorylation site [posttranslational modification] 452637008606 intermolecular recognition site; other site 452637008607 dimerization interface [polypeptide binding]; other site 452637008608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637008609 dimer interface [polypeptide binding]; other site 452637008610 phosphorylation site [posttranslational modification] 452637008611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637008612 ATP binding site [chemical binding]; other site 452637008613 Mg2+ binding site [ion binding]; other site 452637008614 G-X-G motif; other site 452637008615 Response regulator receiver domain; Region: Response_reg; pfam00072 452637008616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637008617 active site 452637008618 phosphorylation site [posttranslational modification] 452637008619 intermolecular recognition site; other site 452637008620 dimerization interface [polypeptide binding]; other site 452637008621 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 452637008622 putative binding surface; other site 452637008623 active site 452637008624 signal recognition particle protein; Provisional; Region: PRK10867 452637008625 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 452637008626 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 452637008627 P loop; other site 452637008628 GTP binding site [chemical binding]; other site 452637008629 Signal peptide binding domain; Region: SRP_SPB; pfam02978 452637008630 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637008631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637008632 active site 452637008633 phosphorylation site [posttranslational modification] 452637008634 intermolecular recognition site; other site 452637008635 dimerization interface [polypeptide binding]; other site 452637008636 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 452637008637 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 452637008638 AsnC family; Region: AsnC_trans_reg; pfam01037 452637008639 hypothetical protein; Validated; Region: PRK07682 452637008640 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452637008641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637008642 homodimer interface [polypeptide binding]; other site 452637008643 catalytic residue [active] 452637008644 GTP-binding protein Der; Reviewed; Region: PRK00093 452637008645 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 452637008646 G1 box; other site 452637008647 GTP/Mg2+ binding site [chemical binding]; other site 452637008648 Switch I region; other site 452637008649 G2 box; other site 452637008650 Switch II region; other site 452637008651 G3 box; other site 452637008652 G4 box; other site 452637008653 G5 box; other site 452637008654 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 452637008655 G1 box; other site 452637008656 GTP/Mg2+ binding site [chemical binding]; other site 452637008657 Switch I region; other site 452637008658 G2 box; other site 452637008659 G3 box; other site 452637008660 Switch II region; other site 452637008661 G4 box; other site 452637008662 G5 box; other site 452637008663 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 452637008664 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 452637008665 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 452637008666 putative active site [active] 452637008667 substrate binding site [chemical binding]; other site 452637008668 putative cosubstrate binding site; other site 452637008669 catalytic site [active] 452637008670 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 452637008671 substrate binding site [chemical binding]; other site 452637008672 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 452637008673 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 452637008674 ParB-like nuclease domain; Region: ParB; smart00470 452637008675 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 452637008676 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 452637008677 E3 interaction surface; other site 452637008678 lipoyl attachment site [posttranslational modification]; other site 452637008679 e3 binding domain; Region: E3_binding; pfam02817 452637008680 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 452637008681 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 452637008682 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 452637008683 alpha subunit interface [polypeptide binding]; other site 452637008684 TPP binding site [chemical binding]; other site 452637008685 heterodimer interface [polypeptide binding]; other site 452637008686 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 452637008687 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 452637008688 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 452637008689 tetramer interface [polypeptide binding]; other site 452637008690 TPP-binding site [chemical binding]; other site 452637008691 heterodimer interface [polypeptide binding]; other site 452637008692 phosphorylation loop region [posttranslational modification] 452637008693 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 452637008694 nudix motif; other site 452637008695 Competence protein A; Region: Competence_A; pfam11104 452637008696 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 452637008697 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 452637008698 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 452637008699 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637008700 putative active site [active] 452637008701 heme pocket [chemical binding]; other site 452637008702 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637008703 dimer interface [polypeptide binding]; other site 452637008704 phosphorylation site [posttranslational modification] 452637008705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637008706 ATP binding site [chemical binding]; other site 452637008707 Mg2+ binding site [ion binding]; other site 452637008708 G-X-G motif; other site 452637008709 Response regulator receiver domain; Region: Response_reg; pfam00072 452637008710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637008711 active site 452637008712 phosphorylation site [posttranslational modification] 452637008713 intermolecular recognition site; other site 452637008714 dimerization interface [polypeptide binding]; other site 452637008715 5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739 452637008716 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 452637008717 active site 452637008718 metal binding site 1 [ion binding]; metal-binding site 452637008719 putative 5' ssDNA interaction site; other site 452637008720 metal binding site 3; metal-binding site 452637008721 metal binding site 2 [ion binding]; metal-binding site 452637008722 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 452637008723 putative DNA binding site [nucleotide binding]; other site 452637008724 putative metal binding site [ion binding]; other site 452637008725 NHL repeat; Region: NHL; pfam01436 452637008726 NHL repeat; Region: NHL; pfam01436 452637008727 NHL repeat; Region: NHL; pfam01436 452637008728 NHL repeat; Region: NHL; pfam01436 452637008729 Immunoglobulin domain; Region: Ig; cl11960 452637008730 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 452637008731 Immunoglobulin I-set domain; Region: I-set; pfam07679 452637008732 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452637008733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637008734 active site 452637008735 phosphorylation site [posttranslational modification] 452637008736 intermolecular recognition site; other site 452637008737 dimerization interface [polypeptide binding]; other site 452637008738 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 452637008739 DNA binding site [nucleotide binding] 452637008740 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 452637008741 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 452637008742 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 452637008743 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 452637008744 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 452637008745 putative active site; other site 452637008746 catalytic triad [active] 452637008747 putative dimer interface [polypeptide binding]; other site 452637008748 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 452637008749 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 452637008750 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 452637008751 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 452637008752 RNA binding site [nucleotide binding]; other site 452637008753 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 452637008754 RNA binding site [nucleotide binding]; other site 452637008755 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 452637008756 RNA binding site [nucleotide binding]; other site 452637008757 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 452637008758 RNA binding site [nucleotide binding]; other site 452637008759 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 452637008760 RNA binding site [nucleotide binding]; other site 452637008761 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 452637008762 RNA binding site [nucleotide binding]; other site 452637008763 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 452637008764 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 452637008765 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 452637008766 classical (c) SDRs; Region: SDR_c; cd05233 452637008767 NAD(P) binding site [chemical binding]; other site 452637008768 active site 452637008769 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 452637008770 Di-iron ligands [ion binding]; other site 452637008771 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_1; cd09156 452637008772 PLD-like domain; Region: PLDc_2; pfam13091 452637008773 putative active site [active] 452637008774 catalytic site [active] 452637008775 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar1_2; cd09162 452637008776 PLD-like domain; Region: PLDc_2; pfam13091 452637008777 putative active site [active] 452637008778 catalytic site [active] 452637008779 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 452637008780 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 452637008781 ligand binding site [chemical binding]; other site 452637008782 flexible hinge region; other site 452637008783 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 452637008784 putative switch regulator; other site 452637008785 non-specific DNA interactions [nucleotide binding]; other site 452637008786 DNA binding site [nucleotide binding] 452637008787 sequence specific DNA binding site [nucleotide binding]; other site 452637008788 putative cAMP binding site [chemical binding]; other site 452637008789 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 452637008790 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 452637008791 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 452637008792 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 452637008793 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 452637008794 Low-spin heme binding site [chemical binding]; other site 452637008795 D-pathway; other site 452637008796 Putative water exit pathway; other site 452637008797 Binuclear center (active site) [active] 452637008798 K-pathway; other site 452637008799 Putative proton exit pathway; other site 452637008800 MarR family; Region: MarR_2; pfam12802 452637008801 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 452637008802 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452637008803 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 452637008804 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 452637008805 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 452637008806 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 452637008807 Iron permease FTR1 family; Region: FTR1; cl00475 452637008808 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 452637008809 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452637008810 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452637008811 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 452637008812 dimerization interface [polypeptide binding]; other site 452637008813 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 452637008814 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 452637008815 homodimer interface [polypeptide binding]; other site 452637008816 substrate-cofactor binding pocket; other site 452637008817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637008818 catalytic residue [active] 452637008819 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 452637008820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452637008821 NAD(P) binding site [chemical binding]; other site 452637008822 active site 452637008823 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637008824 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637008825 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 452637008826 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 452637008827 Cupin domain; Region: Cupin_2; pfam07883 452637008828 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 452637008829 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637008830 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 452637008831 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 452637008832 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637008833 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 452637008834 Uroporphyrinogen decarboxylase (URO-D); Region: URO-D; pfam01208 452637008835 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 452637008836 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 452637008837 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 452637008838 inhibitor-cofactor binding pocket; inhibition site 452637008839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637008840 catalytic residue [active] 452637008841 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 452637008842 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452637008843 catalytic residue [active] 452637008844 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 452637008845 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 452637008846 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 452637008847 Na binding site [ion binding]; other site 452637008848 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 452637008849 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 452637008850 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 452637008851 nucleotide binding site [chemical binding]; other site 452637008852 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 452637008853 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 452637008854 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452637008855 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 452637008856 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 452637008857 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637008858 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452637008859 DNA binding site [nucleotide binding] 452637008860 domain linker motif; other site 452637008861 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 452637008862 ligand binding site [chemical binding]; other site 452637008863 dimerization interface [polypeptide binding]; other site 452637008864 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 452637008865 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 452637008866 Methane oxygenase PmoA; Region: PmoA; pfam14100 452637008867 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 452637008868 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 452637008869 Peptidase family M28; Region: Peptidase_M28; pfam04389 452637008870 metal binding site [ion binding]; metal-binding site 452637008871 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 452637008872 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 452637008873 Na binding site [ion binding]; other site 452637008874 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 452637008875 active site 452637008876 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 452637008877 active site 452637008878 catalytic residues [active] 452637008879 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637008880 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637008881 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 452637008882 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 452637008883 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 452637008884 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637008885 Right handed beta helix region; Region: Beta_helix; pfam13229 452637008886 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 452637008887 dimer interface [polypeptide binding]; other site 452637008888 active site 452637008889 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 452637008890 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452637008891 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 452637008892 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 452637008893 acetylornithine deacetylase; Provisional; Region: PRK07522 452637008894 metal binding site [ion binding]; metal-binding site 452637008895 dimer interface [polypeptide binding]; other site 452637008896 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637008897 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 452637008898 inhibitor site; inhibition site 452637008899 active site 452637008900 dimer interface [polypeptide binding]; other site 452637008901 catalytic residue [active] 452637008902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452637008903 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452637008904 NAD(P) binding site [chemical binding]; other site 452637008905 active site 452637008906 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 452637008907 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 452637008908 substrate-cofactor binding pocket; other site 452637008909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637008910 catalytic residue [active] 452637008911 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 452637008912 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 452637008913 NAD(P) binding site [chemical binding]; other site 452637008914 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452637008915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452637008916 non-specific DNA binding site [nucleotide binding]; other site 452637008917 salt bridge; other site 452637008918 sequence-specific DNA binding site [nucleotide binding]; other site 452637008919 Cupin domain; Region: Cupin_2; pfam07883 452637008920 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 452637008921 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 452637008922 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452637008923 sugar binding site [chemical binding]; other site 452637008924 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637008925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637008926 active site 452637008927 phosphorylation site [posttranslational modification] 452637008928 intermolecular recognition site; other site 452637008929 dimerization interface [polypeptide binding]; other site 452637008930 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637008931 DNA binding residues [nucleotide binding] 452637008932 dimerization interface [polypeptide binding]; other site 452637008933 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452637008934 Histidine kinase; Region: HisKA_3; pfam07730 452637008935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637008936 ATP binding site [chemical binding]; other site 452637008937 Mg2+ binding site [ion binding]; other site 452637008938 G-X-G motif; other site 452637008939 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 452637008940 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 452637008941 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 452637008942 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 452637008943 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 452637008944 Ferritin-like domain; Region: Ferritin; pfam00210 452637008945 dinuclear metal binding motif [ion binding]; other site 452637008946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637008947 S-adenosylmethionine binding site [chemical binding]; other site 452637008948 Family description; Region: VCBS; pfam13517 452637008949 Family description; Region: VCBS; pfam13517 452637008950 Family description; Region: VCBS; pfam13517 452637008951 Family description; Region: VCBS; pfam13517 452637008952 Family description; Region: VCBS; pfam13517 452637008953 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637008954 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 452637008955 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637008956 putative active site [active] 452637008957 heme pocket [chemical binding]; other site 452637008958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637008959 dimer interface [polypeptide binding]; other site 452637008960 phosphorylation site [posttranslational modification] 452637008961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637008962 ATP binding site [chemical binding]; other site 452637008963 Mg2+ binding site [ion binding]; other site 452637008964 G-X-G motif; other site 452637008965 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637008966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637008967 active site 452637008968 phosphorylation site [posttranslational modification] 452637008969 intermolecular recognition site; other site 452637008970 dimerization interface [polypeptide binding]; other site 452637008971 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 452637008972 putative binding surface; other site 452637008973 active site 452637008974 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 452637008975 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 452637008976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637008977 ATP binding site [chemical binding]; other site 452637008978 Mg2+ binding site [ion binding]; other site 452637008979 G-X-G motif; other site 452637008980 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 452637008981 CheW-like domain; Region: CheW; pfam01584 452637008982 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 452637008983 dimer interface [polypeptide binding]; other site 452637008984 putative CheW interface [polypeptide binding]; other site 452637008985 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 452637008986 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 452637008987 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 452637008988 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 452637008989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637008990 active site 452637008991 phosphorylation site [posttranslational modification] 452637008992 intermolecular recognition site; other site 452637008993 dimerization interface [polypeptide binding]; other site 452637008994 CheB methylesterase; Region: CheB_methylest; pfam01339 452637008995 Response regulator receiver domain; Region: Response_reg; pfam00072 452637008996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637008997 active site 452637008998 phosphorylation site [posttranslational modification] 452637008999 intermolecular recognition site; other site 452637009000 dimerization interface [polypeptide binding]; other site 452637009001 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 452637009002 Chemotaxis phosphatase CheX; Region: CheX; cl15816 452637009003 Chemotaxis phosphatase CheX; Region: CheX; cl15816 452637009004 GAF domain; Region: GAF_3; pfam13492 452637009005 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637009006 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637009007 dimer interface [polypeptide binding]; other site 452637009008 phosphorylation site [posttranslational modification] 452637009009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637009010 ATP binding site [chemical binding]; other site 452637009011 Mg2+ binding site [ion binding]; other site 452637009012 G-X-G motif; other site 452637009013 Response regulator receiver domain; Region: Response_reg; pfam00072 452637009014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637009015 active site 452637009016 phosphorylation site [posttranslational modification] 452637009017 intermolecular recognition site; other site 452637009018 dimerization interface [polypeptide binding]; other site 452637009019 Family description; Region: VCBS; pfam13517 452637009020 Family description; Region: VCBS; pfam13517 452637009021 Family description; Region: VCBS; pfam13517 452637009022 Family description; Region: VCBS; pfam13517 452637009023 Family description; Region: VCBS; pfam13517 452637009024 Family description; Region: VCBS; pfam13517 452637009025 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637009026 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 452637009027 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_4; cd07582 452637009028 Predicted amidohydrolase [General function prediction only]; Region: COG0388 452637009029 putative active site [active] 452637009030 catalytic triad [active] 452637009031 putative dimer interface [polypeptide binding]; other site 452637009032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637009033 binding surface 452637009034 TPR motif; other site 452637009035 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452637009036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637009037 binding surface 452637009038 TPR repeat; Region: TPR_11; pfam13414 452637009039 TPR motif; other site 452637009040 Family description; Region: VCBS; pfam13517 452637009041 Family description; Region: VCBS; pfam13517 452637009042 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637009043 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 452637009044 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 452637009045 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 452637009046 ligand binding site [chemical binding]; other site 452637009047 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452637009048 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 452637009049 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 452637009050 ligand binding site [chemical binding]; other site 452637009051 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 452637009052 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 452637009053 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 452637009054 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 452637009055 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 452637009056 Family description; Region: VCBS; pfam13517 452637009057 Family description; Region: VCBS; pfam13517 452637009058 Family description; Region: VCBS; pfam13517 452637009059 Family description; Region: VCBS; pfam13517 452637009060 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637009061 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 452637009062 Family description; Region: VCBS; pfam13517 452637009063 Family description; Region: VCBS; pfam13517 452637009064 Family description; Region: VCBS; pfam13517 452637009065 Family description; Region: VCBS; pfam13517 452637009066 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637009067 Family description; Region: VCBS; pfam13517 452637009068 Family description; Region: VCBS; pfam13517 452637009069 Family description; Region: VCBS; pfam13517 452637009070 Family description; Region: VCBS; pfam13517 452637009071 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637009072 Tetratricopeptide repeat; Region: TPR_16; pfam13432 452637009073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637009074 TPR motif; other site 452637009075 binding surface 452637009076 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637009077 TPR motif; other site 452637009078 Tetratricopeptide repeat; Region: TPR_16; pfam13432 452637009079 binding surface 452637009080 Family description; Region: VCBS; pfam13517 452637009081 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 452637009082 Asparagine synthase; Region: Asn_synthase; pfam00733 452637009083 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1244 452637009084 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 452637009085 FeS/SAM binding site; other site 452637009086 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 452637009087 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 452637009088 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 452637009089 dimerization domain swap beta strand [polypeptide binding]; other site 452637009090 regulatory protein interface [polypeptide binding]; other site 452637009091 active site 452637009092 regulatory phosphorylation site [posttranslational modification]; other site 452637009093 Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579 452637009094 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 452637009095 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 452637009096 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 452637009097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637009098 Response regulator receiver domain; Region: Response_reg; pfam00072 452637009099 active site 452637009100 phosphorylation site [posttranslational modification] 452637009101 intermolecular recognition site; other site 452637009102 dimerization interface [polypeptide binding]; other site 452637009103 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 452637009104 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 452637009105 UDP-glucose 4-epimerase; Region: PLN02240 452637009106 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 452637009107 NAD binding site [chemical binding]; other site 452637009108 homodimer interface [polypeptide binding]; other site 452637009109 active site 452637009110 substrate binding site [chemical binding]; other site 452637009111 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 452637009112 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 452637009113 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 452637009114 intersubunit interface [polypeptide binding]; other site 452637009115 active site 452637009116 catalytic residue [active] 452637009117 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637009118 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637009119 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 452637009120 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 452637009121 Metal-binding active site; metal-binding site 452637009122 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 452637009123 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 452637009124 PYR/PP interface [polypeptide binding]; other site 452637009125 dimer interface [polypeptide binding]; other site 452637009126 TPP binding site [chemical binding]; other site 452637009127 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 452637009128 TPP-binding site [chemical binding]; other site 452637009129 Predicted peptidase [General function prediction only]; Region: COG4099 452637009130 putative hydrolase; Provisional; Region: PRK11460 452637009131 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 452637009132 metal-binding site [ion binding] 452637009133 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 452637009134 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 452637009135 DNA binding residues [nucleotide binding] 452637009136 dimer interface [polypeptide binding]; other site 452637009137 metal binding site [ion binding]; metal-binding site 452637009138 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 452637009139 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 452637009140 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 452637009141 Int/Topo IB signature motif; other site 452637009142 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 452637009143 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 452637009144 active site 452637009145 DNA binding site [nucleotide binding] 452637009146 Int/Topo IB signature motif; other site 452637009147 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 452637009148 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 452637009149 Int/Topo IB signature motif; other site 452637009150 hypothetical protein; Reviewed; Region: PRK00024 452637009151 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 452637009152 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 452637009153 conserved cys residue [active] 452637009154 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 452637009155 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 452637009156 transcription-repair coupling factor (mfd); Region: mfd; TIGR00580 452637009157 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 452637009158 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452637009159 ATP binding site [chemical binding]; other site 452637009160 putative Mg++ binding site [ion binding]; other site 452637009161 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452637009162 nucleotide binding region [chemical binding]; other site 452637009163 ATP-binding site [chemical binding]; other site 452637009164 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 452637009165 ribonuclease III; Reviewed; Region: rnc; PRK00102 452637009166 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 452637009167 dimerization interface [polypeptide binding]; other site 452637009168 active site 452637009169 metal binding site [ion binding]; metal-binding site 452637009170 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 452637009171 dsRNA binding site [nucleotide binding]; other site 452637009172 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 452637009173 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 452637009174 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 452637009175 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 452637009176 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 452637009177 active site 452637009178 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 452637009179 intersubunit interface [polypeptide binding]; other site 452637009180 active site 452637009181 zinc binding site [ion binding]; other site 452637009182 Na+ binding site [ion binding]; other site 452637009183 DNA topoisomerase III; Validated; Region: PRK08173 452637009184 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 452637009185 active site 452637009186 putative interdomain interaction site [polypeptide binding]; other site 452637009187 putative metal-binding site [ion binding]; other site 452637009188 putative nucleotide binding site [chemical binding]; other site 452637009189 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 452637009190 domain I; other site 452637009191 DNA binding groove [nucleotide binding] 452637009192 phosphate binding site [ion binding]; other site 452637009193 domain II; other site 452637009194 domain III; other site 452637009195 nucleotide binding site [chemical binding]; other site 452637009196 catalytic site [active] 452637009197 domain IV; other site 452637009198 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 452637009199 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 452637009200 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 452637009201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 452637009202 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 452637009203 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 452637009204 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452637009205 catalytic residue [active] 452637009206 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 452637009207 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 452637009208 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 452637009209 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 452637009210 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 452637009211 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 452637009212 active site 452637009213 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 452637009214 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 452637009215 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 452637009216 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452637009217 ATP binding site [chemical binding]; other site 452637009218 putative Mg++ binding site [ion binding]; other site 452637009219 nucleotide binding region [chemical binding]; other site 452637009220 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 452637009221 ATP-binding site [chemical binding]; other site 452637009222 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 452637009223 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 452637009224 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 452637009225 HsdM N-terminal domain; Region: HsdM_N; pfam12161 452637009226 Methyltransferase domain; Region: Methyltransf_26; pfam13659 452637009227 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 452637009228 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 452637009229 active site 452637009230 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 452637009231 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 452637009232 DNA binding residues [nucleotide binding] 452637009233 exopolyphosphatase; Region: exo_poly_only; TIGR03706 452637009234 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 452637009235 Predicted methyltransferases [General function prediction only]; Region: COG0313 452637009236 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 452637009237 putative SAM binding site [chemical binding]; other site 452637009238 putative homodimer interface [polypeptide binding]; other site 452637009239 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 452637009240 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 452637009241 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 452637009242 active site 452637009243 dimer interface [polypeptide binding]; other site 452637009244 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 452637009245 dimer interface [polypeptide binding]; other site 452637009246 active site 452637009247 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 452637009248 6-phosphogluconate dehydratase; Region: edd; TIGR01196 452637009249 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 452637009250 Chorismate mutase type II; Region: CM_2; pfam01817 452637009251 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 452637009252 Prephenate dehydratase; Region: PDT; pfam00800 452637009253 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 452637009254 putative L-Phe binding site [chemical binding]; other site 452637009255 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 452637009256 dimer interface [polypeptide binding]; other site 452637009257 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452637009258 ligand binding site [chemical binding]; other site 452637009259 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 452637009260 EamA-like transporter family; Region: EamA; pfam00892 452637009261 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 452637009262 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 452637009263 Cl- selectivity filter; other site 452637009264 Cl- binding residues [ion binding]; other site 452637009265 pore gating glutamate residue; other site 452637009266 dimer interface [polypeptide binding]; other site 452637009267 H+/Cl- coupling transport residue; other site 452637009268 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 452637009269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452637009270 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 452637009271 SnoaL-like domain; Region: SnoaL_2; pfam12680 452637009272 TIGR03118 family protein; Region: PEPCTERM_chp_1 452637009273 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637009274 PAS domain; Region: PAS_9; pfam13426 452637009275 putative active site [active] 452637009276 heme pocket [chemical binding]; other site 452637009277 PAS fold; Region: PAS_4; pfam08448 452637009278 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637009279 putative active site [active] 452637009280 heme pocket [chemical binding]; other site 452637009281 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 452637009282 heme pocket [chemical binding]; other site 452637009283 putative active site [active] 452637009284 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637009285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637009286 dimer interface [polypeptide binding]; other site 452637009287 phosphorylation site [posttranslational modification] 452637009288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637009289 ATP binding site [chemical binding]; other site 452637009290 Mg2+ binding site [ion binding]; other site 452637009291 G-X-G motif; other site 452637009292 Response regulator receiver domain; Region: Response_reg; pfam00072 452637009293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637009294 active site 452637009295 phosphorylation site [posttranslational modification] 452637009296 intermolecular recognition site; other site 452637009297 dimerization interface [polypeptide binding]; other site 452637009298 CHRD domain; Region: CHRD; pfam07452 452637009299 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 452637009300 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 452637009301 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 452637009302 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 452637009303 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 452637009304 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 452637009305 Peptidase family M49; Region: Peptidase_M49; pfam03571 452637009306 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 452637009307 SnoaL-like domain; Region: SnoaL_3; pfam13474 452637009308 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 452637009309 Predicted flavoprotein [General function prediction only]; Region: COG0431 452637009310 Cupin domain; Region: Cupin_2; pfam07883 452637009311 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 452637009312 active site 452637009313 catalytic triad [active] 452637009314 oxyanion hole [active] 452637009315 Hemerythrin; Region: Hemerythrin; cd12107 452637009316 Fe binding site [ion binding]; other site 452637009317 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 452637009318 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 452637009319 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 452637009320 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 452637009321 Uncharacterized conserved protein [Function unknown]; Region: COG5276 452637009322 LVIVD repeat; Region: LVIVD; pfam08309 452637009323 Bacterial Ig-like domain; Region: Big_5; pfam13205 452637009324 IPT/TIG domain; Region: TIG; pfam01833 452637009325 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 452637009326 Bacterial Ig-like domain; Region: Big_5; pfam13205 452637009327 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 452637009328 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 452637009329 Bacterial Ig-like domain; Region: Big_5; pfam13205 452637009330 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 452637009331 IPT/TIG domain; Region: TIG; pfam01833 452637009332 Bacterial Ig-like domain; Region: Big_5; pfam13205 452637009333 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 452637009334 Bacterial Ig-like domain; Region: Big_5; pfam13205 452637009335 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 452637009336 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 452637009337 Bacterial Ig-like domain; Region: Big_5; pfam13205 452637009338 Uncharacterized conserved protein [Function unknown]; Region: COG5276 452637009339 LVIVD repeat; Region: LVIVD; pfam08309 452637009340 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 452637009341 Interdomain contacts; other site 452637009342 Cytokine receptor motif; other site 452637009343 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 452637009344 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 452637009345 Interdomain contacts; other site 452637009346 Cytokine receptor motif; other site 452637009347 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 452637009348 Interdomain contacts; other site 452637009349 Cytokine receptor motif; other site 452637009350 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 452637009351 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 452637009352 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 452637009353 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 452637009354 PA14 domain; Region: PA14; cl08459 452637009355 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 452637009356 Fn3 associated; Region: Fn3_assoc; pfam13287 452637009357 Immunoglobulin domain; Region: Ig_2; pfam13895 452637009358 Immunoglobulin domain; Region: Ig_2; pfam13895 452637009359 Immunoglobulin I-set domain; Region: I-set; pfam07679 452637009360 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 452637009361 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 452637009362 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 452637009363 Bacterial Ig-like domain; Region: Big_5; pfam13205 452637009364 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 452637009365 Bacterial Ig-like domain; Region: Big_5; pfam13205 452637009366 Bacterial Ig-like domain; Region: Big_5; pfam13205 452637009367 Bacterial Ig-like domain; Region: Big_5; pfam13205 452637009368 Cna protein B-type domain; Region: Cna_B_2; pfam13715 452637009369 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 452637009370 IPT/TIG domain; Region: TIG; pfam01833 452637009371 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 452637009372 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 452637009373 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 452637009374 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 452637009375 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 452637009376 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 452637009377 metal binding site 2 [ion binding]; metal-binding site 452637009378 putative DNA binding helix; other site 452637009379 metal binding site 1 [ion binding]; metal-binding site 452637009380 dimer interface [polypeptide binding]; other site 452637009381 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 452637009382 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 452637009383 Cl- selectivity filter; other site 452637009384 Cl- binding residues [ion binding]; other site 452637009385 pore gating glutamate residue; other site 452637009386 dimer interface [polypeptide binding]; other site 452637009387 FOG: CBS domain [General function prediction only]; Region: COG0517 452637009388 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593 452637009389 PAS domain S-box; Region: sensory_box; TIGR00229 452637009390 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637009391 putative active site [active] 452637009392 heme pocket [chemical binding]; other site 452637009393 PAS domain S-box; Region: sensory_box; TIGR00229 452637009394 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637009395 putative active site [active] 452637009396 heme pocket [chemical binding]; other site 452637009397 PAS domain S-box; Region: sensory_box; TIGR00229 452637009398 PAS domain S-box; Region: sensory_box; TIGR00229 452637009399 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 452637009400 putative active site [active] 452637009401 heme pocket [chemical binding]; other site 452637009402 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637009403 PAS domain; Region: PAS_9; pfam13426 452637009404 putative active site [active] 452637009405 heme pocket [chemical binding]; other site 452637009406 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637009407 putative active site [active] 452637009408 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637009409 heme pocket [chemical binding]; other site 452637009410 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637009411 dimer interface [polypeptide binding]; other site 452637009412 phosphorylation site [posttranslational modification] 452637009413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637009414 ATP binding site [chemical binding]; other site 452637009415 Mg2+ binding site [ion binding]; other site 452637009416 G-X-G motif; other site 452637009417 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637009418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637009419 active site 452637009420 phosphorylation site [posttranslational modification] 452637009421 intermolecular recognition site; other site 452637009422 dimerization interface [polypeptide binding]; other site 452637009423 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637009424 PAS fold; Region: PAS_3; pfam08447 452637009425 putative active site [active] 452637009426 heme pocket [chemical binding]; other site 452637009427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637009428 PAS fold; Region: PAS_3; pfam08447 452637009429 putative active site [active] 452637009430 heme pocket [chemical binding]; other site 452637009431 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637009432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637009433 dimer interface [polypeptide binding]; other site 452637009434 phosphorylation site [posttranslational modification] 452637009435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637009436 ATP binding site [chemical binding]; other site 452637009437 Mg2+ binding site [ion binding]; other site 452637009438 G-X-G motif; other site 452637009439 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637009440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637009441 active site 452637009442 phosphorylation site [posttranslational modification] 452637009443 intermolecular recognition site; other site 452637009444 dimerization interface [polypeptide binding]; other site 452637009445 HDOD domain; Region: HDOD; pfam08668 452637009446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637009447 Response regulator receiver domain; Region: Response_reg; pfam00072 452637009448 active site 452637009449 phosphorylation site [posttranslational modification] 452637009450 intermolecular recognition site; other site 452637009451 dimerization interface [polypeptide binding]; other site 452637009452 Protein of unknown function, DUF481; Region: DUF481; pfam04338 452637009453 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 452637009454 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 452637009455 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 452637009456 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 452637009457 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 452637009458 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 452637009459 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 452637009460 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 452637009461 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 452637009462 CoA-binding site [chemical binding]; other site 452637009463 ATP-binding [chemical binding]; other site 452637009464 transcription termination factor Rho; Provisional; Region: rho; PRK09376 452637009465 RNA binding site [nucleotide binding]; other site 452637009466 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 452637009467 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452637009468 Walker A motif; other site 452637009469 ATP binding site [chemical binding]; other site 452637009470 Walker B motif; other site 452637009471 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 452637009472 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 452637009473 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 452637009474 Walker A motif; other site 452637009475 ATP binding site [chemical binding]; other site 452637009476 Walker B motif; other site 452637009477 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 452637009478 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452637009479 Walker A motif; other site 452637009480 ATP binding site [chemical binding]; other site 452637009481 Walker B motif; other site 452637009482 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 452637009483 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 452637009484 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452637009485 Walker A motif; other site 452637009486 ATP binding site [chemical binding]; other site 452637009487 Walker B motif; other site 452637009488 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 452637009489 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 452637009490 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 452637009491 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 452637009492 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 452637009493 generic binding surface I; other site 452637009494 generic binding surface II; other site 452637009495 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452637009496 Zn2+ binding site [ion binding]; other site 452637009497 Mg2+ binding site [ion binding]; other site 452637009498 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 452637009499 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 452637009500 Isochorismatase family; Region: Isochorismatase; pfam00857 452637009501 catalytic triad [active] 452637009502 conserved cis-peptide bond; other site 452637009503 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 452637009504 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 452637009505 active site 452637009506 metal binding site [ion binding]; metal-binding site 452637009507 polyphosphate kinase; Provisional; Region: PRK05443 452637009508 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 452637009509 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 452637009510 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 452637009511 putative domain interface [polypeptide binding]; other site 452637009512 putative active site [active] 452637009513 catalytic site [active] 452637009514 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 452637009515 putative domain interface [polypeptide binding]; other site 452637009516 putative active site [active] 452637009517 catalytic site [active] 452637009518 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 452637009519 PAS fold; Region: PAS_4; pfam08448 452637009520 PAS fold; Region: PAS_4; pfam08448 452637009521 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 452637009522 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 452637009523 oligoendopeptidase F; Region: pepF; TIGR00181 452637009524 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 452637009525 active site 452637009526 Zn binding site [ion binding]; other site 452637009527 GTP-binding protein YchF; Reviewed; Region: PRK09601 452637009528 YchF GTPase; Region: YchF; cd01900 452637009529 G1 box; other site 452637009530 GTP/Mg2+ binding site [chemical binding]; other site 452637009531 Switch I region; other site 452637009532 G2 box; other site 452637009533 Switch II region; other site 452637009534 G3 box; other site 452637009535 G4 box; other site 452637009536 G5 box; other site 452637009537 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 452637009538 Protein of unknown function (DUF456); Region: DUF456; pfam04306 452637009539 ribosomal protein S16; Region: S16; TIGR00002 452637009540 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 452637009541 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 452637009542 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 452637009543 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637009544 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637009545 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 452637009546 Predicted acyl esterases [General function prediction only]; Region: COG2936 452637009547 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 452637009548 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452637009549 DNA binding site [nucleotide binding] 452637009550 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637009551 domain linker motif; other site 452637009552 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 452637009553 ligand binding site [chemical binding]; other site 452637009554 dimerization interface [polypeptide binding]; other site 452637009555 Glycosyl hydrolase family 43; Region: GH43_7; cd08986 452637009556 active site 452637009557 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137 452637009558 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637009559 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637009560 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 452637009561 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 452637009562 active site 452637009563 catalytic residues [active] 452637009564 metal binding site [ion binding]; metal-binding site 452637009565 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 452637009566 CsbD-like; Region: CsbD; pfam05532 452637009567 potassium uptake protein; Region: kup; TIGR00794 452637009568 K+ potassium transporter; Region: K_trans; pfam02705 452637009569 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 452637009570 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 452637009571 substrate binding site [chemical binding]; other site 452637009572 oxyanion hole (OAH) forming residues; other site 452637009573 trimer interface [polypeptide binding]; other site 452637009574 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 452637009575 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 452637009576 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 452637009577 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 452637009578 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 452637009579 NYN domain; Region: NYN; pfam01936 452637009580 Uncharacterized conserved protein [Function unknown]; Region: COG1432 452637009581 putative metal binding site [ion binding]; other site 452637009582 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 452637009583 Uncharacterized conserved protein [Function unknown]; Region: COG3791 452637009584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637009585 S-adenosylmethionine binding site [chemical binding]; other site 452637009586 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 452637009587 Cytochrome c; Region: Cytochrom_C; pfam00034 452637009588 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 452637009589 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 452637009590 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 452637009591 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 452637009592 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 452637009593 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 452637009594 catalytic loop [active] 452637009595 iron binding site [ion binding]; other site 452637009596 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 452637009597 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 452637009598 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 452637009599 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 452637009600 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 452637009601 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 452637009602 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 452637009603 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 452637009604 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 452637009605 Uncharacterized conserved protein [Function unknown]; Region: COG2128 452637009606 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 452637009607 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 452637009608 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637009609 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 452637009610 SnoaL-like domain; Region: SnoaL_2; pfam12680 452637009611 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 452637009612 Mechanosensitive ion channel; Region: MS_channel; pfam00924 452637009613 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452637009614 nucleotide binding site [chemical binding]; other site 452637009615 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 452637009616 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 452637009617 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 452637009618 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 452637009619 substrate binding site [chemical binding]; other site 452637009620 ATP binding site [chemical binding]; other site 452637009621 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 452637009622 active site 452637009623 DNA binding site [nucleotide binding] 452637009624 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 452637009625 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 452637009626 active site 452637009627 metal binding site [ion binding]; metal-binding site 452637009628 ATP-dependent helicase; Provisional; Region: PRK13767 452637009629 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452637009630 ATP binding site [chemical binding]; other site 452637009631 putative Mg++ binding site [ion binding]; other site 452637009632 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452637009633 nucleotide binding region [chemical binding]; other site 452637009634 ATP-binding site [chemical binding]; other site 452637009635 DEAD/H associated; Region: DEAD_assoc; pfam08494 452637009636 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 452637009637 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 452637009638 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 452637009639 ATP-dependent DNA ligase; Provisional; Region: PRK01109 452637009640 Adenylation domain of ATP-dependent DNA Ligases; Region: Adenylation_DNA_ligase; cd07898 452637009641 active site 452637009642 DNA binding site [nucleotide binding] 452637009643 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 452637009644 DNA binding site [nucleotide binding] 452637009645 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 452637009646 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452637009647 Beta-lactamase; Region: Beta-lactamase; pfam00144 452637009648 Immunoglobulin domain; Region: Ig; cd00096 452637009649 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 452637009650 Predicted transcriptional regulators [Transcription]; Region: COG1695 452637009651 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 452637009652 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637009653 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637009654 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637009655 FtsX-like permease family; Region: FtsX; pfam02687 452637009656 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637009657 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637009658 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637009659 TPR motif; other site 452637009660 binding surface 452637009661 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637009662 TPR motif; other site 452637009663 Tetratricopeptide repeat; Region: TPR_16; pfam13432 452637009664 binding surface 452637009665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637009666 binding surface 452637009667 TPR motif; other site 452637009668 TPR repeat; Region: TPR_11; pfam13414 452637009669 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637009670 TPR motif; other site 452637009671 binding surface 452637009672 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 452637009673 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637009674 SnoaL-like domain; Region: SnoaL_3; pfam13474 452637009675 Radical SAM superfamily; Region: Radical_SAM; pfam04055 452637009676 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452637009677 FeS/SAM binding site; other site 452637009678 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 452637009679 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 452637009680 Beta-lactamase; Region: Beta-lactamase; pfam00144 452637009681 Immunoglobulin domain; Region: Ig_2; pfam13895 452637009682 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 452637009683 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 452637009684 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 452637009685 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 452637009686 Protein of unknown function (DUF1302); Region: DUF1302; pfam06980 452637009687 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 452637009688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637009689 Walker A/P-loop; other site 452637009690 ATP binding site [chemical binding]; other site 452637009691 Q-loop/lid; other site 452637009692 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 452637009693 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 452637009694 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 452637009695 Transcriptional regulator; Region: Transcrip_reg; pfam01709 452637009696 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 452637009697 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 452637009698 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 452637009699 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 452637009700 active site 452637009701 DNA binding site [nucleotide binding] 452637009702 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 452637009703 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 452637009704 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 452637009705 active site 452637009706 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 452637009707 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 452637009708 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 452637009709 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 452637009710 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452637009711 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 452637009712 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 452637009713 Beta-Casp domain; Region: Beta-Casp; pfam10996 452637009714 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 452637009715 Protein of unknown function (DUF525); Region: DUF525; pfam04379 452637009716 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 452637009717 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 452637009718 purine monophosphate binding site [chemical binding]; other site 452637009719 dimer interface [polypeptide binding]; other site 452637009720 putative catalytic residues [active] 452637009721 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 452637009722 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 452637009723 Peptidase family M48; Region: Peptidase_M48; pfam01435 452637009724 hypothetical protein; Validated; Region: PRK09104 452637009725 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 452637009726 metal binding site [ion binding]; metal-binding site 452637009727 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 452637009728 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 452637009729 ligand binding site [chemical binding]; other site 452637009730 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637009731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637009732 active site 452637009733 phosphorylation site [posttranslational modification] 452637009734 intermolecular recognition site; other site 452637009735 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637009736 DNA binding residues [nucleotide binding] 452637009737 dimerization interface [polypeptide binding]; other site 452637009738 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 452637009739 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637009740 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637009741 DNA binding residues [nucleotide binding] 452637009742 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 452637009743 RuvA N terminal domain; Region: RuvA_N; pfam01330 452637009744 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 452637009745 dihydrodipicolinate reductase; Provisional; Region: PRK00048 452637009746 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 452637009747 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 452637009748 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 452637009749 dihydrodipicolinate synthase; Region: dapA; TIGR00674 452637009750 dimer interface [polypeptide binding]; other site 452637009751 active site 452637009752 catalytic residue [active] 452637009753 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 452637009754 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452637009755 Walker A motif; other site 452637009756 ATP binding site [chemical binding]; other site 452637009757 Walker B motif; other site 452637009758 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 452637009759 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 452637009760 GTP-binding protein LepA; Provisional; Region: PRK05433 452637009761 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 452637009762 G1 box; other site 452637009763 putative GEF interaction site [polypeptide binding]; other site 452637009764 GTP/Mg2+ binding site [chemical binding]; other site 452637009765 Switch I region; other site 452637009766 G2 box; other site 452637009767 G3 box; other site 452637009768 Switch II region; other site 452637009769 G4 box; other site 452637009770 G5 box; other site 452637009771 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 452637009772 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 452637009773 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 452637009774 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 452637009775 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 452637009776 Catalytic site [active] 452637009777 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 452637009778 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 452637009779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637009780 binding surface 452637009781 TPR motif; other site 452637009782 TPR repeat; Region: TPR_11; pfam13414 452637009783 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637009784 binding surface 452637009785 TPR motif; other site 452637009786 TPR repeat; Region: TPR_11; pfam13414 452637009787 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637009788 TPR motif; other site 452637009789 TPR repeat; Region: TPR_11; pfam13414 452637009790 binding surface 452637009791 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637009792 Family description; Region: VCBS; pfam13517 452637009793 Family description; Region: VCBS; pfam13517 452637009794 Family description; Region: VCBS; pfam13517 452637009795 Family description; Region: VCBS; pfam13517 452637009796 Family description; Region: VCBS; pfam13517 452637009797 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637009798 Family description; Region: VCBS; pfam13517 452637009799 Family description; Region: VCBS; pfam13517 452637009800 Family description; Region: VCBS; pfam13517 452637009801 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637009802 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 452637009803 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637009804 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452637009805 DNA binding site [nucleotide binding] 452637009806 domain linker motif; other site 452637009807 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 452637009808 dimerization interface [polypeptide binding]; other site 452637009809 ligand binding site [chemical binding]; other site 452637009810 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 452637009811 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 452637009812 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637009813 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 452637009814 active site 452637009815 oxyanion hole [active] 452637009816 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637009817 Tetratricopeptide repeat; Region: TPR_16; pfam13432 452637009818 binding surface 452637009819 TPR motif; other site 452637009820 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637009821 TPR motif; other site 452637009822 binding surface 452637009823 Glycosyl hydrolase family 43; Region: GH43_2; cd08981 452637009824 active site 452637009825 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 452637009826 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 452637009827 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 452637009828 Domain of unknown function (DUF303); Region: DUF303; pfam03629 452637009829 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 452637009830 Domain of unknown function (DUF303); Region: DUF303; pfam03629 452637009831 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 452637009832 active site 452637009833 zinc binding site [ion binding]; other site 452637009834 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 452637009835 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 452637009836 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 452637009837 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 452637009838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 452637009839 Protein of unknown function (DUF1593); Region: DUF1593; pfam07632 452637009840 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 452637009841 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 452637009842 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 452637009843 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 452637009844 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 452637009845 putative metal binding site [ion binding]; other site 452637009846 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 452637009847 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 452637009848 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 452637009849 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 452637009850 He_PIG associated, NEW1 domain of bacterial glycohydrolase; Region: He_PIG_assoc; pfam10632 452637009851 Putative Ig domain; Region: He_PIG; pfam05345 452637009852 alpha-galactosidase; Region: PLN02808; cl17638 452637009853 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 452637009854 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 452637009855 putative active site [active] 452637009856 putative catalytic site [active] 452637009857 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 452637009858 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 452637009859 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 452637009860 Putative esterase; Region: Esterase; pfam00756 452637009861 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 452637009862 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 452637009863 active site 452637009864 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 452637009865 substrate binding site [chemical binding]; other site 452637009866 active site 452637009867 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 452637009868 metal binding site [ion binding]; metal-binding site 452637009869 ligand binding site [chemical binding]; other site 452637009870 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 452637009871 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 452637009872 Carboxylesterase family; Region: COesterase; pfam00135 452637009873 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 452637009874 substrate binding pocket [chemical binding]; other site 452637009875 catalytic triad [active] 452637009876 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 452637009877 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 452637009878 putative ligand binding site [chemical binding]; other site 452637009879 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 452637009880 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 452637009881 inhibitor binding site; inhibition site 452637009882 active site 452637009883 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637009884 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452637009885 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637009886 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 452637009887 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637009888 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 452637009889 Histidine kinase; Region: HisKA_3; pfam07730 452637009890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637009891 ATP binding site [chemical binding]; other site 452637009892 Mg2+ binding site [ion binding]; other site 452637009893 G-X-G motif; other site 452637009894 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637009895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637009896 active site 452637009897 phosphorylation site [posttranslational modification] 452637009898 intermolecular recognition site; other site 452637009899 dimerization interface [polypeptide binding]; other site 452637009900 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637009901 DNA binding residues [nucleotide binding] 452637009902 dimerization interface [polypeptide binding]; other site 452637009903 Family description; Region: VCBS; pfam13517 452637009904 Family description; Region: VCBS; pfam13517 452637009905 Family description; Region: VCBS; pfam13517 452637009906 Family description; Region: VCBS; pfam13517 452637009907 Family description; Region: VCBS; pfam13517 452637009908 Family description; Region: VCBS; pfam13517 452637009909 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637009910 Family description; Region: VCBS; pfam13517 452637009911 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 452637009912 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637009913 Family description; Region: VCBS; pfam13517 452637009914 Family description; Region: VCBS; pfam13517 452637009915 Family description; Region: VCBS; pfam13517 452637009916 Family description; Region: VCBS; pfam13517 452637009917 Family description; Region: VCBS; pfam13517 452637009918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637009919 binding surface 452637009920 TPR motif; other site 452637009921 TPR repeat; Region: TPR_11; pfam13414 452637009922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637009923 binding surface 452637009924 TPR motif; other site 452637009925 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637009926 TPR motif; other site 452637009927 binding surface 452637009928 TPR repeat; Region: TPR_11; pfam13414 452637009929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637009930 TPR motif; other site 452637009931 binding surface 452637009932 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 452637009933 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 452637009934 active site 452637009935 Glycosyl hydrolase family 62, characterized arabinofuranosidases; Region: GH62; cd08987 452637009936 active site 452637009937 Immunoglobulin C-2 Type; Region: IGc2; smart00408 452637009938 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637009939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637009940 active site 452637009941 phosphorylation site [posttranslational modification] 452637009942 intermolecular recognition site; other site 452637009943 dimerization interface [polypeptide binding]; other site 452637009944 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637009945 DNA binding residues [nucleotide binding] 452637009946 dimerization interface [polypeptide binding]; other site 452637009947 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 452637009948 Bacterial sugar transferase; Region: Bac_transf; pfam02397 452637009949 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 452637009950 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 452637009951 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 452637009952 SLBB domain; Region: SLBB; pfam10531 452637009953 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 452637009954 Chain length determinant protein; Region: Wzz; cl15801 452637009955 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 452637009956 O-Antigen ligase; Region: Wzy_C; pfam04932 452637009957 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 452637009958 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 452637009959 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 452637009960 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 452637009961 Walker A/P-loop; other site 452637009962 ATP binding site [chemical binding]; other site 452637009963 Q-loop/lid; other site 452637009964 ABC transporter signature motif; other site 452637009965 Walker B; other site 452637009966 D-loop; other site 452637009967 H-loop/switch region; other site 452637009968 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 452637009969 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637009970 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637009971 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 452637009972 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452637009973 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452637009974 NAD(P) binding site [chemical binding]; other site 452637009975 active site 452637009976 Core-2/I-Branching enzyme; Region: Branch; pfam02485 452637009977 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 452637009978 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452637009979 active site 452637009980 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637009981 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452637009982 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 452637009983 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 452637009984 active site 452637009985 Protein of unknown function (DUF563); Region: DUF563; pfam04577 452637009986 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637009987 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452637009988 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637009989 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 452637009990 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 452637009991 putative ADP-binding pocket [chemical binding]; other site 452637009992 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637009993 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452637009994 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637009995 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 452637009996 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 452637009997 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 452637009998 Ligand Binding Site [chemical binding]; other site 452637009999 Molecular Tunnel; other site 452637010000 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 452637010001 putative metal binding site; other site 452637010002 Protein of unknown function (DUF4002); Region: DUF4002; pfam13164 452637010003 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 452637010004 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 452637010005 active site 452637010006 substrate binding site [chemical binding]; other site 452637010007 trimer interface [polypeptide binding]; other site 452637010008 CoA binding site [chemical binding]; other site 452637010009 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 452637010010 active site 452637010011 Zn binding site [ion binding]; other site 452637010012 Nrap protein; Region: Nrap; pfam03813 452637010013 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 452637010014 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 452637010015 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 452637010016 putative glycosyl transferase; Provisional; Region: PRK10307 452637010017 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 452637010018 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 452637010019 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 452637010020 putative ATP binding site [chemical binding]; other site 452637010021 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 452637010022 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 452637010023 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 452637010024 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 452637010025 putative ADP-binding pocket [chemical binding]; other site 452637010026 4-alpha-glucanotransferase; Provisional; Region: PRK14508 452637010027 haloalkane dehalogenase; Provisional; Region: PRK03592 452637010028 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 452637010029 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 452637010030 active site 452637010031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452637010032 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 452637010033 NAD(P) binding site [chemical binding]; other site 452637010034 active site 452637010035 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 452637010036 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 452637010037 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 452637010038 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 452637010039 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 452637010040 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 452637010041 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452637010042 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 452637010043 DNA binding site [nucleotide binding] 452637010044 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 452637010045 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 452637010046 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 452637010047 Phosphopantetheine attachment site; Region: PP-binding; cl09936 452637010048 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 452637010049 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 452637010050 dimer interface [polypeptide binding]; other site 452637010051 active site 452637010052 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 452637010053 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 452637010054 NAD binding site [chemical binding]; other site 452637010055 homodimer interface [polypeptide binding]; other site 452637010056 active site 452637010057 substrate binding site [chemical binding]; other site 452637010058 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 452637010059 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 452637010060 FOG: CBS domain [General function prediction only]; Region: COG0517 452637010061 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 452637010062 malate dehydrogenase; Provisional; Region: PRK13529 452637010063 Malic enzyme, N-terminal domain; Region: malic; pfam00390 452637010064 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 452637010065 NAD(P) binding site [chemical binding]; other site 452637010066 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 452637010067 Putative esterase; Region: Esterase; pfam00756 452637010068 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 452637010069 Response regulator receiver domain; Region: Response_reg; pfam00072 452637010070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637010071 active site 452637010072 phosphorylation site [posttranslational modification] 452637010073 intermolecular recognition site; other site 452637010074 dimerization interface [polypeptide binding]; other site 452637010075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637010076 Walker A motif; other site 452637010077 ATP binding site [chemical binding]; other site 452637010078 Walker B motif; other site 452637010079 arginine finger; other site 452637010080 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 452637010081 Peptidase family M50; Region: Peptidase_M50; pfam02163 452637010082 active site 452637010083 putative substrate binding region [chemical binding]; other site 452637010084 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 452637010085 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 452637010086 transmembrane helices; other site 452637010087 PAS domain S-box; Region: sensory_box; TIGR00229 452637010088 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637010089 putative active site [active] 452637010090 heme pocket [chemical binding]; other site 452637010091 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637010092 PAS fold; Region: PAS_3; pfam08447 452637010093 putative active site [active] 452637010094 heme pocket [chemical binding]; other site 452637010095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637010096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637010097 dimer interface [polypeptide binding]; other site 452637010098 phosphorylation site [posttranslational modification] 452637010099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637010100 ATP binding site [chemical binding]; other site 452637010101 Mg2+ binding site [ion binding]; other site 452637010102 G-X-G motif; other site 452637010103 Response regulator receiver domain; Region: Response_reg; pfam00072 452637010104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637010105 active site 452637010106 phosphorylation site [posttranslational modification] 452637010107 intermolecular recognition site; other site 452637010108 dimerization interface [polypeptide binding]; other site 452637010109 potassium uptake protein; Region: kup; TIGR00794 452637010110 K+ potassium transporter; Region: K_trans; pfam02705 452637010111 membrane ATPase/protein kinase; Provisional; Region: PRK09435 452637010112 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 452637010113 Walker A; other site 452637010114 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 452637010115 active site clefts [active] 452637010116 zinc binding site [ion binding]; other site 452637010117 dimer interface [polypeptide binding]; other site 452637010118 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 452637010119 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 452637010120 active site 452637010121 substrate binding site [chemical binding]; other site 452637010122 coenzyme B12 binding site [chemical binding]; other site 452637010123 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 452637010124 B12 binding site [chemical binding]; other site 452637010125 cobalt ligand [ion binding]; other site 452637010126 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 452637010127 heterodimer interface [polypeptide binding]; other site 452637010128 substrate interaction site [chemical binding]; other site 452637010129 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 452637010130 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452637010131 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 452637010132 dimer interface [polypeptide binding]; other site 452637010133 substrate binding site [chemical binding]; other site 452637010134 metal binding site [ion binding]; metal-binding site 452637010135 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 452637010136 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 452637010137 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 452637010138 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 452637010139 carboxyltransferase (CT) interaction site; other site 452637010140 biotinylation site [posttranslational modification]; other site 452637010141 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 452637010142 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 452637010143 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 452637010144 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 452637010145 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 452637010146 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 452637010147 active site 452637010148 catalytic residues [active] 452637010149 metal binding site [ion binding]; metal-binding site 452637010150 homodimer binding site [polypeptide binding]; other site 452637010151 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 452637010152 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 452637010153 hexamer (dimer of trimers) interface [polypeptide binding]; other site 452637010154 substrate binding site [chemical binding]; other site 452637010155 trimer interface [polypeptide binding]; other site 452637010156 Mn binding site [ion binding]; other site 452637010157 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 452637010158 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 452637010159 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 452637010160 putative ligand binding site [chemical binding]; other site 452637010161 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 452637010162 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 452637010163 Walker A/P-loop; other site 452637010164 ATP binding site [chemical binding]; other site 452637010165 Q-loop/lid; other site 452637010166 ABC transporter signature motif; other site 452637010167 Walker B; other site 452637010168 D-loop; other site 452637010169 H-loop/switch region; other site 452637010170 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 452637010171 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 452637010172 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 452637010173 TM-ABC transporter signature motif; other site 452637010174 TolA protein; Region: tolA_full; TIGR02794 452637010175 TonB C terminal; Region: TonB_2; pfam13103 452637010176 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 452637010177 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 452637010178 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 452637010179 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 452637010180 ATP binding site [chemical binding]; other site 452637010181 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 452637010182 substrate binding site [chemical binding]; other site 452637010183 thymidylate kinase; Validated; Region: tmk; PRK00698 452637010184 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 452637010185 TMP-binding site; other site 452637010186 ATP-binding site [chemical binding]; other site 452637010187 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 452637010188 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 452637010189 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 452637010190 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452637010191 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 452637010192 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 452637010193 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637010194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637010195 ATP binding site [chemical binding]; other site 452637010196 Mg2+ binding site [ion binding]; other site 452637010197 G-X-G motif; other site 452637010198 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 452637010199 Predicted amidohydrolase [General function prediction only]; Region: COG0388 452637010200 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 452637010201 active site 452637010202 catalytic triad [active] 452637010203 dimer interface [polypeptide binding]; other site 452637010204 YCII-related domain; Region: YCII; cl00999 452637010205 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 452637010206 putative dimer interface [polypeptide binding]; other site 452637010207 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452637010208 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 452637010209 PLD-like domain; Region: PLDc_2; pfam13091 452637010210 putative active site [active] 452637010211 catalytic site [active] 452637010212 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 452637010213 PLD-like domain; Region: PLDc_2; pfam13091 452637010214 putative active site [active] 452637010215 catalytic site [active] 452637010216 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 452637010217 YCII-related domain; Region: YCII; cl00999 452637010218 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 452637010219 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637010220 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 452637010221 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 452637010222 classical (c) SDRs; Region: SDR_c; cd05233 452637010223 NAD(P) binding site [chemical binding]; other site 452637010224 active site 452637010225 glucose-1-dehydrogenase; Provisional; Region: PRK08936 452637010226 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 452637010227 NAD binding site [chemical binding]; other site 452637010228 homodimer interface [polypeptide binding]; other site 452637010229 active site 452637010230 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637010231 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637010232 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637010233 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 452637010234 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 452637010235 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 452637010236 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 452637010237 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 452637010238 beta-D-glucuronidase; Provisional; Region: PRK10150 452637010239 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 452637010240 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 452637010241 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 452637010242 dimer interface [polypeptide binding]; other site 452637010243 putative CheW interface [polypeptide binding]; other site 452637010244 PBP superfamily domain; Region: PBP_like_2; cl17296 452637010245 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 452637010246 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637010247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 452637010248 phosphorylation site [posttranslational modification] 452637010249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637010250 ATP binding site [chemical binding]; other site 452637010251 Mg2+ binding site [ion binding]; other site 452637010252 G-X-G motif; other site 452637010253 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637010254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637010255 active site 452637010256 phosphorylation site [posttranslational modification] 452637010257 intermolecular recognition site; other site 452637010258 dimerization interface [polypeptide binding]; other site 452637010259 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637010260 DNA binding residues [nucleotide binding] 452637010261 dimerization interface [polypeptide binding]; other site 452637010262 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 452637010263 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 452637010264 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452637010265 ATP binding site [chemical binding]; other site 452637010266 putative Mg++ binding site [ion binding]; other site 452637010267 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452637010268 nucleotide binding region [chemical binding]; other site 452637010269 ATP-binding site [chemical binding]; other site 452637010270 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 452637010271 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 452637010272 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 452637010273 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 452637010274 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 452637010275 G1 box; other site 452637010276 putative GEF interaction site [polypeptide binding]; other site 452637010277 GTP/Mg2+ binding site [chemical binding]; other site 452637010278 Switch I region; other site 452637010279 G2 box; other site 452637010280 G3 box; other site 452637010281 Switch II region; other site 452637010282 G4 box; other site 452637010283 G5 box; other site 452637010284 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 452637010285 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 452637010286 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 452637010287 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 452637010288 HlyD family secretion protein; Region: HlyD_3; pfam13437 452637010289 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 452637010290 lipoyl attachment site [posttranslational modification]; other site 452637010291 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 452637010292 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 452637010293 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 452637010294 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 452637010295 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 452637010296 ligand binding site; other site 452637010297 oligomer interface; other site 452637010298 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 452637010299 dimer interface [polypeptide binding]; other site 452637010300 N-terminal domain interface [polypeptide binding]; other site 452637010301 sulfate 1 binding site; other site 452637010302 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 452637010303 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 452637010304 glutaminase active site [active] 452637010305 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 452637010306 dimer interface [polypeptide binding]; other site 452637010307 active site 452637010308 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 452637010309 dimer interface [polypeptide binding]; other site 452637010310 active site 452637010311 anthranilate synthase component I; Provisional; Region: PRK13565 452637010312 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 452637010313 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 452637010314 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 452637010315 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 452637010316 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637010317 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 452637010318 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637010319 DNA binding residues [nucleotide binding] 452637010320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637010321 TPR motif; other site 452637010322 binding surface 452637010323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637010324 TPR motif; other site 452637010325 binding surface 452637010326 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 452637010327 active site 452637010328 catalytic triad [active] 452637010329 oxyanion hole [active] 452637010330 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 452637010331 Ca2+ binding site [ion binding]; other site 452637010332 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637010333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637010334 active site 452637010335 phosphorylation site [posttranslational modification] 452637010336 intermolecular recognition site; other site 452637010337 dimerization interface [polypeptide binding]; other site 452637010338 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637010339 DNA binding residues [nucleotide binding] 452637010340 dimerization interface [polypeptide binding]; other site 452637010341 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452637010342 Histidine kinase; Region: HisKA_3; pfam07730 452637010343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637010344 ATP binding site [chemical binding]; other site 452637010345 Mg2+ binding site [ion binding]; other site 452637010346 G-X-G motif; other site 452637010347 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637010348 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452637010349 DNA binding site [nucleotide binding] 452637010350 domain linker motif; other site 452637010351 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452637010352 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 452637010353 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 452637010354 Ligand Binding Site [chemical binding]; other site 452637010355 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 452637010356 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 452637010357 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 452637010358 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 452637010359 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 452637010360 HNH endonuclease; Region: HNH_3; pfam13392 452637010361 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 452637010362 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 452637010363 AAA domain; Region: AAA_22; pfam13401 452637010364 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 452637010365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452637010366 non-specific DNA binding site [nucleotide binding]; other site 452637010367 salt bridge; other site 452637010368 sequence-specific DNA binding site [nucleotide binding]; other site 452637010369 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 452637010370 Protein of unknown function (DUF935); Region: DUF935; pfam06074 452637010371 chromosome segregation protein; Provisional; Region: PRK03918 452637010372 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 452637010373 DNA topoisomerase III; Validated; Region: PRK08173 452637010374 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 452637010375 active site 452637010376 putative interdomain interaction site [polypeptide binding]; other site 452637010377 putative metal-binding site [ion binding]; other site 452637010378 putative nucleotide binding site [chemical binding]; other site 452637010379 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 452637010380 domain I; other site 452637010381 DNA binding groove [nucleotide binding] 452637010382 phosphate binding site [ion binding]; other site 452637010383 domain II; other site 452637010384 domain III; other site 452637010385 nucleotide binding site [chemical binding]; other site 452637010386 catalytic site [active] 452637010387 domain IV; other site 452637010388 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 452637010389 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 452637010390 O-Antigen ligase; Region: Wzy_C; pfam04932 452637010391 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 452637010392 Bacterial sugar transferase; Region: Bac_transf; pfam02397 452637010393 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 452637010394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 452637010395 non-specific DNA binding site [nucleotide binding]; other site 452637010396 salt bridge; other site 452637010397 sequence-specific DNA binding site [nucleotide binding]; other site 452637010398 Transcriptional regulator [Transcription]; Region: LysR; COG0583 452637010399 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 452637010400 LysR substrate binding domain; Region: LysR_substrate; pfam03466 452637010401 dimerization interface [polypeptide binding]; other site 452637010402 Protein of unknown function (DUF3485); Region: DUF3485; cl11827 452637010403 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 452637010404 putative ADP-binding pocket [chemical binding]; other site 452637010405 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637010406 Methyltransferase domain; Region: Methyltransf_23; pfam13489 452637010407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637010408 S-adenosylmethionine binding site [chemical binding]; other site 452637010409 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637010410 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452637010411 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 452637010412 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 452637010413 active site 452637010414 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452637010415 active site 452637010416 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452637010417 active site 452637010418 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 452637010419 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 452637010420 four helix bundle protein; Region: TIGR02436 452637010421 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 452637010422 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637010423 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637010424 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 452637010425 DHH family; Region: DHH; pfam01368 452637010426 DHHA1 domain; Region: DHHA1; pfam02272 452637010427 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 452637010428 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 452637010429 Protein export membrane protein; Region: SecD_SecF; pfam02355 452637010430 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 452637010431 arginine decarboxylase; Provisional; Region: PRK05354 452637010432 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 452637010433 active site 452637010434 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 452637010435 catalytic residues [active] 452637010436 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 452637010437 Yqey-like protein; Region: YqeY; pfam09424 452637010438 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 452637010439 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 452637010440 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 452637010441 dimerization interface [polypeptide binding]; other site 452637010442 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 452637010443 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 452637010444 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637010445 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 452637010446 endonuclease III; Region: ENDO3c; smart00478 452637010447 minor groove reading motif; other site 452637010448 helix-hairpin-helix signature motif; other site 452637010449 substrate binding pocket [chemical binding]; other site 452637010450 active site 452637010451 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 452637010452 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 452637010453 DNA binding site [nucleotide binding] 452637010454 active site 452637010455 CheD chemotactic sensory transduction; Region: CheD; cl00810 452637010456 HDOD domain; Region: HDOD; pfam08668 452637010457 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452637010458 Zn2+ binding site [ion binding]; other site 452637010459 Mg2+ binding site [ion binding]; other site 452637010460 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 452637010461 active site 452637010462 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 452637010463 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 452637010464 inhibitor-cofactor binding pocket; inhibition site 452637010465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637010466 catalytic residue [active] 452637010467 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 452637010468 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 452637010469 active site 452637010470 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 452637010471 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 452637010472 domain interfaces; other site 452637010473 active site 452637010474 ketol-acid reductoisomerase; Region: ilvC; TIGR00465 452637010475 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 452637010476 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 452637010477 Dehydratase family; Region: ILVD_EDD; cl00340 452637010478 Dehydratase family; Region: ILVD_EDD; cl00340 452637010479 ketol-acid reductoisomerase; Provisional; Region: PRK05479 452637010480 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 452637010481 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 452637010482 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 452637010483 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 452637010484 putative valine binding site [chemical binding]; other site 452637010485 dimer interface [polypeptide binding]; other site 452637010486 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 452637010487 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 452637010488 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 452637010489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 452637010490 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 452637010491 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 452637010492 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 452637010493 Soluble P-type ATPase [General function prediction only]; Region: COG4087 452637010494 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 452637010495 DEAD_2; Region: DEAD_2; pfam06733 452637010496 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 452637010497 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 452637010498 active site 452637010499 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 452637010500 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 452637010501 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 452637010502 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 452637010503 Surface antigen; Region: Bac_surface_Ag; pfam01103 452637010504 Family of unknown function (DUF490); Region: DUF490; pfam04357 452637010505 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 452637010506 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 452637010507 active site 452637010508 Zn binding site [ion binding]; other site 452637010509 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637010510 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 452637010511 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 452637010512 C-terminal peptidase (prc); Region: prc; TIGR00225 452637010513 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 452637010514 protein binding site [polypeptide binding]; other site 452637010515 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 452637010516 Catalytic dyad [active] 452637010517 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 452637010518 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 452637010519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637010520 S-adenosylmethionine binding site [chemical binding]; other site 452637010521 peptide chain release factor 1; Validated; Region: prfA; PRK00591 452637010522 This domain is found in peptide chain release factors; Region: PCRF; smart00937 452637010523 RF-1 domain; Region: RF-1; pfam00472 452637010524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 452637010525 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 452637010526 CHASE2 domain; Region: CHASE2; pfam05226 452637010527 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 452637010528 cyclase homology domain; Region: CHD; cd07302 452637010529 nucleotidyl binding site; other site 452637010530 metal binding site [ion binding]; metal-binding site 452637010531 dimer interface [polypeptide binding]; other site 452637010532 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452637010533 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637010534 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637010535 DNA binding residues [nucleotide binding] 452637010536 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 452637010537 FecR protein; Region: FecR; pfam04773 452637010538 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 452637010539 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 452637010540 N-terminal plug; other site 452637010541 ligand-binding site [chemical binding]; other site 452637010542 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 452637010543 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452637010544 ATP binding site [chemical binding]; other site 452637010545 putative Mg++ binding site [ion binding]; other site 452637010546 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452637010547 nucleotide binding region [chemical binding]; other site 452637010548 ATP-binding site [chemical binding]; other site 452637010549 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637010550 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637010551 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452637010552 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637010553 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637010554 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637010555 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637010556 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637010557 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637010558 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 452637010559 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 452637010560 sugar binding site [chemical binding]; other site 452637010561 TIGR03663 family protein; Region: TIGR03663 452637010562 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 452637010563 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 452637010564 Ligand binding site; other site 452637010565 Putative Catalytic site; other site 452637010566 DXD motif; other site 452637010567 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 452637010568 Active site serine [active] 452637010569 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 452637010570 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 452637010571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637010572 catalytic residue [active] 452637010573 aspartate kinase; Reviewed; Region: PRK06635 452637010574 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 452637010575 putative nucleotide binding site [chemical binding]; other site 452637010576 putative catalytic residues [active] 452637010577 putative Mg ion binding site [ion binding]; other site 452637010578 putative aspartate binding site [chemical binding]; other site 452637010579 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 452637010580 putative allosteric regulatory site; other site 452637010581 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 452637010582 putative allosteric regulatory residue; other site 452637010583 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 452637010584 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 452637010585 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 452637010586 ligand binding site [chemical binding]; other site 452637010587 NAD binding site [chemical binding]; other site 452637010588 dimerization interface [polypeptide binding]; other site 452637010589 catalytic site [active] 452637010590 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 452637010591 putative L-serine binding site [chemical binding]; other site 452637010592 HD domain; Region: HD_3; pfam13023 452637010593 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 452637010594 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 452637010595 Zn2+ binding site [ion binding]; other site 452637010596 Mg2+ binding site [ion binding]; other site 452637010597 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 452637010598 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 452637010599 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 452637010600 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 452637010601 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 452637010602 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 452637010603 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 452637010604 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 452637010605 active site 452637010606 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 452637010607 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 452637010608 dimerization interface 3.5A [polypeptide binding]; other site 452637010609 active site 452637010610 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 452637010611 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452637010612 motif II; other site 452637010613 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 452637010614 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 452637010615 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 452637010616 ATP binding site [chemical binding]; other site 452637010617 substrate interface [chemical binding]; other site 452637010618 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 452637010619 active site residue [active] 452637010620 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 452637010621 legume lectins; Region: lectin_L-type; cl14058 452637010622 homotetramer interaction site [polypeptide binding]; other site 452637010623 carbohydrate binding site [chemical binding]; other site 452637010624 metal binding site [ion binding]; metal-binding site 452637010625 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 452637010626 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 452637010627 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 452637010628 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 452637010629 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 452637010630 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 452637010631 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 452637010632 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 452637010633 Magnesium ion binding site [ion binding]; other site 452637010634 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 452637010635 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 452637010636 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 452637010637 Restriction endonuclease; Region: Mrr_cat; pfam04471 452637010638 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 452637010639 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 452637010640 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 452637010641 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 452637010642 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 452637010643 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 452637010644 Cytochrome c; Region: Cytochrom_C; pfam00034 452637010645 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 452637010646 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 452637010647 D-pathway; other site 452637010648 Putative ubiquinol binding site [chemical binding]; other site 452637010649 Low-spin heme (heme b) binding site [chemical binding]; other site 452637010650 Putative water exit pathway; other site 452637010651 Binuclear center (heme o3/CuB) [ion binding]; other site 452637010652 K-pathway; other site 452637010653 Putative proton exit pathway; other site 452637010654 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 452637010655 Subunit I/III interface [polypeptide binding]; other site 452637010656 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 452637010657 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 452637010658 iron-sulfur cluster [ion binding]; other site 452637010659 [2Fe-2S] cluster binding site [ion binding]; other site 452637010660 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 452637010661 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 452637010662 intrachain domain interface; other site 452637010663 interchain domain interface [polypeptide binding]; other site 452637010664 heme bH binding site [chemical binding]; other site 452637010665 Qi binding site; other site 452637010666 heme bL binding site [chemical binding]; other site 452637010667 Qo binding site; other site 452637010668 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 452637010669 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 452637010670 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 452637010671 inhibitor binding site; inhibition site 452637010672 active site 452637010673 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 452637010674 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 452637010675 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 452637010676 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 452637010677 inhibitor-cofactor binding pocket; inhibition site 452637010678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637010679 catalytic residue [active] 452637010680 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 452637010681 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 452637010682 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 452637010683 active site 452637010684 DNA binding site [nucleotide binding] 452637010685 Int/Topo IB signature motif; other site 452637010686 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 452637010687 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 452637010688 homodimer interface [polypeptide binding]; other site 452637010689 metal binding site [ion binding]; metal-binding site 452637010690 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 452637010691 active site 452637010692 ribulose/triose binding site [chemical binding]; other site 452637010693 phosphate binding site [ion binding]; other site 452637010694 substrate (anthranilate) binding pocket [chemical binding]; other site 452637010695 product (indole) binding pocket [chemical binding]; other site 452637010696 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 452637010697 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 452637010698 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 452637010699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452637010700 Coenzyme A binding pocket [chemical binding]; other site 452637010701 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 452637010702 B12 binding domain; Region: B12-binding; pfam02310 452637010703 B12 binding site [chemical binding]; other site 452637010704 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 452637010705 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 452637010706 N- and C-terminal domain interface [polypeptide binding]; other site 452637010707 D-xylulose kinase; Region: XylB; TIGR01312 452637010708 active site 452637010709 MgATP binding site [chemical binding]; other site 452637010710 catalytic site [active] 452637010711 metal binding site [ion binding]; metal-binding site 452637010712 xylulose binding site [chemical binding]; other site 452637010713 putative homodimer interface [polypeptide binding]; other site 452637010714 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637010715 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 452637010716 putative active site [active] 452637010717 heme pocket [chemical binding]; other site 452637010718 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637010719 putative active site [active] 452637010720 heme pocket [chemical binding]; other site 452637010721 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637010722 dimer interface [polypeptide binding]; other site 452637010723 phosphorylation site [posttranslational modification] 452637010724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637010725 ATP binding site [chemical binding]; other site 452637010726 Mg2+ binding site [ion binding]; other site 452637010727 G-X-G motif; other site 452637010728 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637010729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637010730 active site 452637010731 phosphorylation site [posttranslational modification] 452637010732 intermolecular recognition site; other site 452637010733 dimerization interface [polypeptide binding]; other site 452637010734 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 452637010735 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 452637010736 Walker A/P-loop; other site 452637010737 ATP binding site [chemical binding]; other site 452637010738 Q-loop/lid; other site 452637010739 ABC transporter signature motif; other site 452637010740 Walker B; other site 452637010741 D-loop; other site 452637010742 H-loop/switch region; other site 452637010743 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 452637010744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 452637010745 NMT1/THI5 like; Region: NMT1; pfam09084 452637010746 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 452637010747 substrate binding pocket [chemical binding]; other site 452637010748 membrane-bound complex binding site; other site 452637010749 Methyltransferase domain; Region: Methyltransf_31; pfam13847 452637010750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637010751 S-adenosylmethionine binding site [chemical binding]; other site 452637010752 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 452637010753 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 452637010754 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 452637010755 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 452637010756 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452637010757 FeS/SAM binding site; other site 452637010758 TRAM domain; Region: TRAM; cl01282 452637010759 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 452637010760 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 452637010761 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 452637010762 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 452637010763 protein binding site [polypeptide binding]; other site 452637010764 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 452637010765 protein binding site [polypeptide binding]; other site 452637010766 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 452637010767 protein binding site [polypeptide binding]; other site 452637010768 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 452637010769 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 452637010770 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 452637010771 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 452637010772 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 452637010773 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452637010774 Walker A/P-loop; other site 452637010775 ATP binding site [chemical binding]; other site 452637010776 Q-loop/lid; other site 452637010777 ABC transporter signature motif; other site 452637010778 Walker B; other site 452637010779 D-loop; other site 452637010780 H-loop/switch region; other site 452637010781 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 452637010782 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 452637010783 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452637010784 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452637010785 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637010786 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637010787 dimer interface [polypeptide binding]; other site 452637010788 phosphorylation site [posttranslational modification] 452637010789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637010790 ATP binding site [chemical binding]; other site 452637010791 Mg2+ binding site [ion binding]; other site 452637010792 G-X-G motif; other site 452637010793 Response regulator receiver domain; Region: Response_reg; pfam00072 452637010794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637010795 active site 452637010796 phosphorylation site [posttranslational modification] 452637010797 intermolecular recognition site; other site 452637010798 dimerization interface [polypeptide binding]; other site 452637010799 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 452637010800 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 452637010801 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 452637010802 dimer interface [polypeptide binding]; other site 452637010803 putative CheW interface [polypeptide binding]; other site 452637010804 Nitrate and nitrite sensing; Region: NIT; pfam08376 452637010805 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 452637010806 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 452637010807 dimer interface [polypeptide binding]; other site 452637010808 putative CheW interface [polypeptide binding]; other site 452637010809 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 452637010810 homotrimer interaction site [polypeptide binding]; other site 452637010811 putative active site [active] 452637010812 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 452637010813 Amidase; Region: Amidase; cl11426 452637010814 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 452637010815 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 452637010816 active site 452637010817 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 452637010818 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 452637010819 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 452637010820 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 452637010821 active site 452637010822 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 452637010823 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 452637010824 Ligand Binding Site [chemical binding]; other site 452637010825 manganese transport protein MntH; Reviewed; Region: PRK00701 452637010826 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 452637010827 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 452637010828 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 452637010829 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 452637010830 FeoA domain; Region: FeoA; pfam04023 452637010831 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 452637010832 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 452637010833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452637010834 dimer interface [polypeptide binding]; other site 452637010835 conserved gate region; other site 452637010836 putative PBP binding loops; other site 452637010837 ABC-ATPase subunit interface; other site 452637010838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452637010839 dimer interface [polypeptide binding]; other site 452637010840 conserved gate region; other site 452637010841 putative PBP binding loops; other site 452637010842 ABC-ATPase subunit interface; other site 452637010843 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452637010844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637010845 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 452637010846 Glyco_18 domain; Region: Glyco_18; smart00636 452637010847 active site 452637010848 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 452637010849 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 452637010850 P-loop; other site 452637010851 Magnesium ion binding site [ion binding]; other site 452637010852 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 452637010853 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 452637010854 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 452637010855 active site 452637010856 substrate binding site [chemical binding]; other site 452637010857 metal binding site [ion binding]; metal-binding site 452637010858 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 452637010859 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 452637010860 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 452637010861 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 452637010862 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 452637010863 putative phosphate acyltransferase; Provisional; Region: PRK05331 452637010864 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 452637010865 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 452637010866 dimer interface [polypeptide binding]; other site 452637010867 active site 452637010868 CoA binding pocket [chemical binding]; other site 452637010869 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 452637010870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 452637010871 TPR motif; other site 452637010872 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 452637010873 binding surface 452637010874 Lipopolysaccharide-assembly; Region: LptE; pfam04390 452637010875 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 452637010876 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 452637010877 substrate binding site [chemical binding]; other site 452637010878 hexamer interface [polypeptide binding]; other site 452637010879 metal binding site [ion binding]; metal-binding site 452637010880 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 452637010881 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 452637010882 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 452637010883 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 452637010884 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 452637010885 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 452637010886 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 452637010887 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 452637010888 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 452637010889 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 452637010890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637010891 Walker A/P-loop; other site 452637010892 ATP binding site [chemical binding]; other site 452637010893 Q-loop/lid; other site 452637010894 ABC transporter signature motif; other site 452637010895 Walker B; other site 452637010896 D-loop; other site 452637010897 H-loop/switch region; other site 452637010898 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 452637010899 active site 452637010900 excinuclease ABC subunit B; Provisional; Region: PRK05298 452637010901 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452637010902 ATP binding site [chemical binding]; other site 452637010903 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452637010904 nucleotide binding region [chemical binding]; other site 452637010905 ATP-binding site [chemical binding]; other site 452637010906 Ultra-violet resistance protein B; Region: UvrB; pfam12344 452637010907 UvrB/uvrC motif; Region: UVR; pfam02151 452637010908 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 452637010909 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 452637010910 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 452637010911 NAD(P) binding site [chemical binding]; other site 452637010912 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 452637010913 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637010914 putative homodimer interface [polypeptide binding]; other site 452637010915 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 452637010916 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 452637010917 UDP-galactopyranose mutase; Region: GLF; pfam03275 452637010918 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 452637010919 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 452637010920 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 452637010921 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 452637010922 Dodecin; Region: Dodecin; pfam07311 452637010923 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 452637010924 Peptidase family M50; Region: Peptidase_M50; pfam02163 452637010925 active site 452637010926 putative substrate binding region [chemical binding]; other site 452637010927 FOG: CBS domain [General function prediction only]; Region: COG0517 452637010928 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 452637010929 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 452637010930 Uncharacterized conserved protein [Function unknown]; Region: COG4198 452637010931 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 452637010932 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 452637010933 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 452637010934 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 452637010935 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 452637010936 catalytic motif [active] 452637010937 Zn binding site [ion binding]; other site 452637010938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452637010939 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 452637010940 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 452637010941 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 452637010942 active site 452637010943 Uncharacterized conserved protein [Function unknown]; Region: COG0327 452637010944 dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486 452637010945 Dehydroquinase class II; Region: DHquinase_II; pfam01220 452637010946 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 452637010947 trimer interface [polypeptide binding]; other site 452637010948 active site 452637010949 dimer interface [polypeptide binding]; other site 452637010950 transcriptional activator RfaH; Region: RfaH; TIGR01955 452637010951 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895 452637010952 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 452637010953 tetramer interfaces [polypeptide binding]; other site 452637010954 binuclear metal-binding site [ion binding]; other site 452637010955 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 452637010956 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 452637010957 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 452637010958 active site 452637010959 (T/H)XGH motif; other site 452637010960 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 452637010961 HlyD family secretion protein; Region: HlyD_3; pfam13437 452637010962 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452637010963 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452637010964 Walker A/P-loop; other site 452637010965 ATP binding site [chemical binding]; other site 452637010966 Q-loop/lid; other site 452637010967 ABC transporter signature motif; other site 452637010968 Walker B; other site 452637010969 D-loop; other site 452637010970 H-loop/switch region; other site 452637010971 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637010972 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 452637010973 TPR repeat; Region: TPR_11; pfam13414 452637010974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637010975 binding surface 452637010976 TPR motif; other site 452637010977 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 452637010978 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 452637010979 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 452637010980 dimer interface [polypeptide binding]; other site 452637010981 tetramer interface [polypeptide binding]; other site 452637010982 PYR/PP interface [polypeptide binding]; other site 452637010983 TPP binding site [chemical binding]; other site 452637010984 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 452637010985 TPP-binding site; other site 452637010986 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 452637010987 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 452637010988 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 452637010989 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 452637010990 chorismate binding enzyme; Region: Chorismate_bind; cl10555 452637010991 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 452637010992 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 452637010993 active site 452637010994 HIGH motif; other site 452637010995 KMSKS motif; other site 452637010996 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 452637010997 tRNA binding surface [nucleotide binding]; other site 452637010998 anticodon binding site; other site 452637010999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 452637011000 Histidine kinase; Region: HisKA_3; pfam07730 452637011001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637011002 ATP binding site [chemical binding]; other site 452637011003 Mg2+ binding site [ion binding]; other site 452637011004 G-X-G motif; other site 452637011005 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 452637011006 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 452637011007 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 452637011008 active site 452637011009 dimerization interface [polypeptide binding]; other site 452637011010 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 452637011011 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 452637011012 catalytic motif [active] 452637011013 Zn binding site [ion binding]; other site 452637011014 RibD C-terminal domain; Region: RibD_C; cl17279 452637011015 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 452637011016 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 452637011017 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 452637011018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637011019 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637011020 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 452637011021 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 452637011022 B12 binding site [chemical binding]; other site 452637011023 cobalt ligand [ion binding]; other site 452637011024 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 452637011025 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 452637011026 Active site serine [active] 452637011027 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 452637011028 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 452637011029 tartrate dehydrogenase; Provisional; Region: PRK08194 452637011030 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 452637011031 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 452637011032 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 452637011033 catalytic site [active] 452637011034 active site 452637011035 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 452637011036 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 452637011037 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 452637011038 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 452637011039 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 452637011040 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 452637011041 active site 452637011042 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 452637011043 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 452637011044 N-terminal plug; other site 452637011045 ligand-binding site [chemical binding]; other site 452637011046 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 452637011047 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 452637011048 Sodium Bile acid symporter family; Region: SBF; cl17470 452637011049 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 452637011050 Low molecular weight phosphatase family; Region: LMWPc; cd00115 452637011051 active site 452637011052 Protein of unknown function (DUF563); Region: DUF563; pfam04577 452637011053 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 452637011054 Interdomain contacts; other site 452637011055 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 452637011056 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 452637011057 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 452637011058 Interdomain contacts; other site 452637011059 Cytokine receptor motif; other site 452637011060 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 452637011061 Interdomain contacts; other site 452637011062 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 452637011063 Interdomain contacts; other site 452637011064 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 452637011065 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 452637011066 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452637011067 active site 452637011068 HIGH motif; other site 452637011069 nucleotide binding site [chemical binding]; other site 452637011070 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 452637011071 KMSKS motif; other site 452637011072 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 452637011073 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 452637011074 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 452637011075 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 452637011076 Cysteine-rich domain; Region: CCG; pfam02754 452637011077 Cysteine-rich domain; Region: CCG; pfam02754 452637011078 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 452637011079 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452637011080 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 452637011081 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 452637011082 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 452637011083 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 452637011084 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 452637011085 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 452637011086 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 452637011087 nickel binding site [ion binding]; other site 452637011088 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 452637011089 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 452637011090 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637011091 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637011092 DNA binding residues [nucleotide binding] 452637011093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 452637011094 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 452637011095 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 452637011096 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 452637011097 catalytic residues [active] 452637011098 Restriction endonuclease; Region: Mrr_cat; pfam04471 452637011099 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 452637011100 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452637011101 ATP binding site [chemical binding]; other site 452637011102 putative Mg++ binding site [ion binding]; other site 452637011103 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452637011104 nucleotide binding region [chemical binding]; other site 452637011105 ATP-binding site [chemical binding]; other site 452637011106 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 452637011107 HRDC domain; Region: HRDC; pfam00570 452637011108 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 452637011109 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 452637011110 homodimer interface [polypeptide binding]; other site 452637011111 substrate-cofactor binding pocket; other site 452637011112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637011113 catalytic residue [active] 452637011114 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 452637011115 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 452637011116 Uncharacterized conserved protein [Function unknown]; Region: COG2966 452637011117 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 452637011118 cobyric acid synthase; Provisional; Region: PRK00784 452637011119 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 452637011120 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 452637011121 catalytic triad [active] 452637011122 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 452637011123 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637011124 Walker A/P-loop; other site 452637011125 ATP binding site [chemical binding]; other site 452637011126 Q-loop/lid; other site 452637011127 ABC transporter signature motif; other site 452637011128 Walker B; other site 452637011129 D-loop; other site 452637011130 H-loop/switch region; other site 452637011131 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 452637011132 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 452637011133 ABC-ATPase subunit interface; other site 452637011134 dimer interface [polypeptide binding]; other site 452637011135 putative PBP binding regions; other site 452637011136 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 452637011137 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 452637011138 intersubunit interface [polypeptide binding]; other site 452637011139 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 452637011140 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 452637011141 N-terminal plug; other site 452637011142 ligand-binding site [chemical binding]; other site 452637011143 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 452637011144 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 452637011145 motif II; other site 452637011146 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 452637011147 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 452637011148 putative catalytic site [active] 452637011149 putative metal binding site [ion binding]; other site 452637011150 putative phosphate binding site [ion binding]; other site 452637011151 short chain dehydrogenase; Provisional; Region: PRK07109 452637011152 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 452637011153 putative NAD(P) binding site [chemical binding]; other site 452637011154 active site 452637011155 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 452637011156 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 452637011157 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 452637011158 active site 452637011159 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04537 452637011160 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 452637011161 ATP binding site [chemical binding]; other site 452637011162 Mg++ binding site [ion binding]; other site 452637011163 motif III; other site 452637011164 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452637011165 nucleotide binding region [chemical binding]; other site 452637011166 ATP-binding site [chemical binding]; other site 452637011167 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 452637011168 RNA binding site [nucleotide binding]; other site 452637011169 Methyltransferase domain; Region: Methyltransf_23; pfam13489 452637011170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637011171 S-adenosylmethionine binding site [chemical binding]; other site 452637011172 Phosphoribosylaminoimidazole (AIR) synthetase [Nucleotide transport and metabolism]; Region: PurM; COG0150 452637011173 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 452637011174 ATP binding site [chemical binding]; other site 452637011175 dimerization interface [polypeptide binding]; other site 452637011176 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 452637011177 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 452637011178 active site 452637011179 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 452637011180 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 452637011181 dimerization interface [polypeptide binding]; other site 452637011182 ATP binding site [chemical binding]; other site 452637011183 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 452637011184 dimerization interface [polypeptide binding]; other site 452637011185 ATP binding site [chemical binding]; other site 452637011186 AIR synthase related protein, C-terminal domain; Region: AIRS_C; pfam02769 452637011187 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 452637011188 putative active site [active] 452637011189 catalytic triad [active] 452637011190 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 452637011191 EamA-like transporter family; Region: EamA; pfam00892 452637011192 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 452637011193 hypothetical protein; Provisional; Region: PRK11239 452637011194 Protein of unknown function, DUF480; Region: DUF480; pfam04337 452637011195 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 452637011196 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 452637011197 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 452637011198 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 452637011199 active site 452637011200 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 452637011201 Right handed beta helix region; Region: Beta_helix; pfam13229 452637011202 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452637011203 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637011204 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637011205 DNA binding residues [nucleotide binding] 452637011206 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 452637011207 FecR protein; Region: FecR; pfam04773 452637011208 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 452637011209 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637011210 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 452637011211 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637011212 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 452637011213 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 452637011214 putative dimer interface [polypeptide binding]; other site 452637011215 putative anticodon binding site; other site 452637011216 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 452637011217 homodimer interface [polypeptide binding]; other site 452637011218 motif 1; other site 452637011219 motif 2; other site 452637011220 active site 452637011221 motif 3; other site 452637011222 phosphoserine phosphatase; Provisional; Region: thrH; PRK13582 452637011223 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 452637011224 ParB-like nuclease domain; Region: ParBc; cl02129 452637011225 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 452637011226 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 452637011227 TrkA-C domain; Region: TrkA_C; pfam02080 452637011228 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 452637011229 Uncharacterized conserved protein [Function unknown]; Region: COG2128 452637011230 Protein transport protein SEC31; Region: Sec31; pfam11549 452637011231 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 452637011232 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 452637011233 protein binding site [polypeptide binding]; other site 452637011234 Cupin domain; Region: Cupin_2; pfam07883 452637011235 Cupin domain; Region: Cupin_2; pfam07883 452637011236 DTW domain; Region: DTW; cl01221 452637011237 aspartate aminotransferase; Provisional; Region: PRK05764 452637011238 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452637011239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637011240 homodimer interface [polypeptide binding]; other site 452637011241 catalytic residue [active] 452637011242 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 452637011243 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452637011244 dimerization interface [polypeptide binding]; other site 452637011245 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637011246 dimer interface [polypeptide binding]; other site 452637011247 phosphorylation site [posttranslational modification] 452637011248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637011249 ATP binding site [chemical binding]; other site 452637011250 Mg2+ binding site [ion binding]; other site 452637011251 G-X-G motif; other site 452637011252 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 452637011253 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 452637011254 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 452637011255 active site 452637011256 substrate binding site [chemical binding]; other site 452637011257 metal binding site [ion binding]; metal-binding site 452637011258 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 452637011259 substrate binding site; other site 452637011260 dimerization interface; other site 452637011261 Septum formation initiator; Region: DivIC; cl17659 452637011262 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 452637011263 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637011264 Walker A motif; other site 452637011265 ATP binding site [chemical binding]; other site 452637011266 Walker B motif; other site 452637011267 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 452637011268 MutS domain I; Region: MutS_I; pfam01624 452637011269 MutS domain II; Region: MutS_II; pfam05188 452637011270 MutS domain III; Region: MutS_III; pfam05192 452637011271 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 452637011272 Walker A/P-loop; other site 452637011273 ATP binding site [chemical binding]; other site 452637011274 Q-loop/lid; other site 452637011275 ABC transporter signature motif; other site 452637011276 Walker B; other site 452637011277 D-loop; other site 452637011278 H-loop/switch region; other site 452637011279 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 452637011280 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 452637011281 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 452637011282 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 452637011283 active site 452637011284 Maf-like protein; Region: Maf; pfam02545 452637011285 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 452637011286 active site 452637011287 dimer interface [polypeptide binding]; other site 452637011288 NAD synthetase; Provisional; Region: PRK13981 452637011289 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 452637011290 multimer interface [polypeptide binding]; other site 452637011291 active site 452637011292 catalytic triad [active] 452637011293 protein interface 1 [polypeptide binding]; other site 452637011294 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 452637011295 homodimer interface [polypeptide binding]; other site 452637011296 NAD binding pocket [chemical binding]; other site 452637011297 ATP binding pocket [chemical binding]; other site 452637011298 Mg binding site [ion binding]; other site 452637011299 active-site loop [active] 452637011300 ApbE family; Region: ApbE; pfam02424 452637011301 RNA polymerase sigma factor; Provisional; Region: PRK11922 452637011302 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637011303 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637011304 DNA binding residues [nucleotide binding] 452637011305 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 452637011306 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 452637011307 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 452637011308 four helix bundle protein; Region: TIGR02436 452637011309 PGAP1-like protein; Region: PGAP1; pfam07819 452637011310 acyl-CoA esterase; Provisional; Region: PRK10673 452637011311 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 452637011312 Bacterial sugar transferase; Region: Bac_transf; pfam02397 452637011313 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 452637011314 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 452637011315 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637011316 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 452637011317 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637011318 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 452637011319 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 452637011320 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637011321 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 452637011322 metal binding site [ion binding]; metal-binding site 452637011323 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 452637011324 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 452637011325 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 452637011326 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 452637011327 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 452637011328 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 452637011329 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637011330 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637011331 DNA binding residues [nucleotide binding] 452637011332 DEAD-like helicases superfamily; Region: DEXDc; smart00487 452637011333 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452637011334 ATP binding site [chemical binding]; other site 452637011335 putative Mg++ binding site [ion binding]; other site 452637011336 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452637011337 nucleotide binding region [chemical binding]; other site 452637011338 ATP-binding site [chemical binding]; other site 452637011339 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 452637011340 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 452637011341 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 452637011342 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 452637011343 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 452637011344 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 452637011345 protein binding site [polypeptide binding]; other site 452637011346 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 452637011347 Catalytic dyad [active] 452637011348 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 452637011349 ribosomal protein L28; Region: L28; TIGR00009 452637011350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637011351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637011352 dimer interface [polypeptide binding]; other site 452637011353 phosphorylation site [posttranslational modification] 452637011354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637011355 ATP binding site [chemical binding]; other site 452637011356 Mg2+ binding site [ion binding]; other site 452637011357 G-X-G motif; other site 452637011358 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637011359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637011360 active site 452637011361 phosphorylation site [posttranslational modification] 452637011362 intermolecular recognition site; other site 452637011363 dimerization interface [polypeptide binding]; other site 452637011364 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 452637011365 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 452637011366 dimer interface [polypeptide binding]; other site 452637011367 active site 452637011368 acyl carrier protein; Provisional; Region: acpP; PRK00982 452637011369 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 452637011370 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 452637011371 NAD(P) binding site [chemical binding]; other site 452637011372 homotetramer interface [polypeptide binding]; other site 452637011373 homodimer interface [polypeptide binding]; other site 452637011374 active site 452637011375 FAD binding domain; Region: FAD_binding_1; pfam00667 452637011376 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 452637011377 FAD binding pocket [chemical binding]; other site 452637011378 FAD binding motif [chemical binding]; other site 452637011379 catalytic residues [active] 452637011380 NAD binding pocket [chemical binding]; other site 452637011381 phosphate binding motif [ion binding]; other site 452637011382 beta-alpha-beta structure motif; other site 452637011383 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 452637011384 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 452637011385 RNA binding surface [nucleotide binding]; other site 452637011386 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 452637011387 active site 452637011388 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 452637011389 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 452637011390 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 452637011391 homodimer interface [polypeptide binding]; other site 452637011392 NADP binding site [chemical binding]; other site 452637011393 substrate binding site [chemical binding]; other site 452637011394 Response regulator receiver domain; Region: Response_reg; pfam00072 452637011395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637011396 active site 452637011397 phosphorylation site [posttranslational modification] 452637011398 intermolecular recognition site; other site 452637011399 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637011400 dimerization interface [polypeptide binding]; other site 452637011401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637011402 dimer interface [polypeptide binding]; other site 452637011403 phosphorylation site [posttranslational modification] 452637011404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637011405 ATP binding site [chemical binding]; other site 452637011406 G-X-G motif; other site 452637011407 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 452637011408 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 452637011409 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 452637011410 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 452637011411 Walker A/P-loop; other site 452637011412 ATP binding site [chemical binding]; other site 452637011413 Q-loop/lid; other site 452637011414 ABC transporter signature motif; other site 452637011415 Walker B; other site 452637011416 D-loop; other site 452637011417 H-loop/switch region; other site 452637011418 TOBE domain; Region: TOBE_2; pfam08402 452637011419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452637011420 dimer interface [polypeptide binding]; other site 452637011421 conserved gate region; other site 452637011422 putative PBP binding loops; other site 452637011423 ABC-ATPase subunit interface; other site 452637011424 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 452637011425 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 452637011426 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 452637011427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452637011428 dimer interface [polypeptide binding]; other site 452637011429 conserved gate region; other site 452637011430 putative PBP binding loops; other site 452637011431 ABC-ATPase subunit interface; other site 452637011432 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 452637011433 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 452637011434 multidrug efflux protein; Reviewed; Region: PRK09579 452637011435 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 452637011436 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 452637011437 HlyD family secretion protein; Region: HlyD_3; pfam13437 452637011438 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452637011439 MarR family; Region: MarR; pfam01047 452637011440 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 452637011441 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 452637011442 TPP-binding site [chemical binding]; other site 452637011443 dimer interface [polypeptide binding]; other site 452637011444 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 452637011445 PYR/PP interface [polypeptide binding]; other site 452637011446 dimer interface [polypeptide binding]; other site 452637011447 TPP binding site [chemical binding]; other site 452637011448 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 452637011449 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 452637011450 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 452637011451 Substrate binding site; other site 452637011452 Cupin domain; Region: Cupin_2; cl17218 452637011453 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 452637011454 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 452637011455 NAD(P) binding site [chemical binding]; other site 452637011456 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 452637011457 pseudouridine synthase; Region: TIGR00093 452637011458 active site 452637011459 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 452637011460 FMN binding site [chemical binding]; other site 452637011461 dimer interface [polypeptide binding]; other site 452637011462 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 452637011463 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 452637011464 active site 452637011465 FMN binding site [chemical binding]; other site 452637011466 substrate binding site [chemical binding]; other site 452637011467 homotetramer interface [polypeptide binding]; other site 452637011468 catalytic residue [active] 452637011469 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 452637011470 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 452637011471 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 452637011472 NADP binding site [chemical binding]; other site 452637011473 homodimer interface [polypeptide binding]; other site 452637011474 active site 452637011475 substrate binding site [chemical binding]; other site 452637011476 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 452637011477 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 452637011478 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 452637011479 HlyD family secretion protein; Region: HlyD_3; pfam13437 452637011480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 452637011481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 452637011482 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452637011483 Coenzyme A binding pocket [chemical binding]; other site 452637011484 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 452637011485 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 452637011486 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 452637011487 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 452637011488 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 452637011489 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 452637011490 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 452637011491 substrate binding pocket [chemical binding]; other site 452637011492 chain length determination region; other site 452637011493 substrate-Mg2+ binding site; other site 452637011494 catalytic residues [active] 452637011495 aspartate-rich region 1; other site 452637011496 active site lid residues [active] 452637011497 aspartate-rich region 2; other site 452637011498 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 452637011499 Immunoglobulin C-2 Type; Region: IGc2; smart00408 452637011500 triosephosphate isomerase; Provisional; Region: PRK14567 452637011501 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 452637011502 substrate binding site [chemical binding]; other site 452637011503 dimer interface [polypeptide binding]; other site 452637011504 catalytic triad [active] 452637011505 Phosphoglycerate kinase; Region: PGK; pfam00162 452637011506 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 452637011507 substrate binding site [chemical binding]; other site 452637011508 hinge regions; other site 452637011509 ADP binding site [chemical binding]; other site 452637011510 catalytic site [active] 452637011511 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 452637011512 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 452637011513 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 452637011514 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 452637011515 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 452637011516 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 452637011517 active site 452637011518 catalytic site [active] 452637011519 Sulfatase; Region: Sulfatase; cl17466 452637011520 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 452637011521 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 452637011522 Ligand Binding Site [chemical binding]; other site 452637011523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637011524 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637011525 active site 452637011526 phosphorylation site [posttranslational modification] 452637011527 intermolecular recognition site; other site 452637011528 dimerization interface [polypeptide binding]; other site 452637011529 HDOD domain; Region: HDOD; pfam08668 452637011530 TPR repeat; Region: TPR_11; pfam13414 452637011531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637011532 TPR motif; other site 452637011533 binding surface 452637011534 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 452637011535 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 452637011536 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 452637011537 Walker A motif; other site 452637011538 ATP binding site [chemical binding]; other site 452637011539 Walker B motif; other site 452637011540 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 452637011541 GTP1/OBG; Region: GTP1_OBG; pfam01018 452637011542 Obg GTPase; Region: Obg; cd01898 452637011543 G1 box; other site 452637011544 GTP/Mg2+ binding site [chemical binding]; other site 452637011545 Switch I region; other site 452637011546 G2 box; other site 452637011547 G3 box; other site 452637011548 Switch II region; other site 452637011549 G4 box; other site 452637011550 G5 box; other site 452637011551 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452637011552 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 452637011553 active site 452637011554 catalytic tetrad [active] 452637011555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637011556 putative substrate translocation pore; other site 452637011557 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452637011558 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 452637011559 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 452637011560 motif 1; other site 452637011561 active site 452637011562 motif 2; other site 452637011563 motif 3; other site 452637011564 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 452637011565 DHHA1 domain; Region: DHHA1; pfam02272 452637011566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637011567 dimer interface [polypeptide binding]; other site 452637011568 phosphorylation site [posttranslational modification] 452637011569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637011570 ATP binding site [chemical binding]; other site 452637011571 Mg2+ binding site [ion binding]; other site 452637011572 G-X-G motif; other site 452637011573 Response regulator receiver domain; Region: Response_reg; pfam00072 452637011574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637011575 active site 452637011576 phosphorylation site [posttranslational modification] 452637011577 intermolecular recognition site; other site 452637011578 dimerization interface [polypeptide binding]; other site 452637011579 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 452637011580 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 452637011581 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 452637011582 glycogen branching enzyme; Provisional; Region: PRK05402 452637011583 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 452637011584 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 452637011585 active site 452637011586 catalytic site [active] 452637011587 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 452637011588 OstA-like protein; Region: OstA; cl00844 452637011589 Organic solvent tolerance protein; Region: OstA_C; pfam04453 452637011590 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 452637011591 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 452637011592 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 452637011593 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 452637011594 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 452637011595 catalytic residues [active] 452637011596 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 452637011597 UbiA prenyltransferase family; Region: UbiA; pfam01040 452637011598 Acylphosphatase; Region: Acylphosphatase; pfam00708 452637011599 Adenosylhomocysteinase; Provisional; Region: PTZ00075 452637011600 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 452637011601 homotetramer interface [polypeptide binding]; other site 452637011602 ligand binding site [chemical binding]; other site 452637011603 catalytic site [active] 452637011604 NAD binding site [chemical binding]; other site 452637011605 S-adenosylmethionine synthetase; Validated; Region: PRK05250 452637011606 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 452637011607 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 452637011608 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 452637011609 Response regulator receiver domain; Region: Response_reg; pfam00072 452637011610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637011611 active site 452637011612 phosphorylation site [posttranslational modification] 452637011613 intermolecular recognition site; other site 452637011614 dimerization interface [polypeptide binding]; other site 452637011615 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637011616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637011617 dimer interface [polypeptide binding]; other site 452637011618 phosphorylation site [posttranslational modification] 452637011619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637011620 ATP binding site [chemical binding]; other site 452637011621 Mg2+ binding site [ion binding]; other site 452637011622 G-X-G motif; other site 452637011623 Response regulator receiver domain; Region: Response_reg; pfam00072 452637011624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637011625 active site 452637011626 phosphorylation site [posttranslational modification] 452637011627 intermolecular recognition site; other site 452637011628 dimerization interface [polypeptide binding]; other site 452637011629 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 452637011630 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 452637011631 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452637011632 Walker A motif; other site 452637011633 ATP binding site [chemical binding]; other site 452637011634 Walker B motif; other site 452637011635 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 452637011636 putative binding surface; other site 452637011637 active site 452637011638 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 452637011639 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 452637011640 Ligand binding site; other site 452637011641 DXD motif; other site 452637011642 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 452637011643 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 452637011644 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 452637011645 Fe-S cluster binding site [ion binding]; other site 452637011646 active site 452637011647 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 452637011648 Lumazine binding domain; Region: Lum_binding; pfam00677 452637011649 Lumazine binding domain; Region: Lum_binding; pfam00677 452637011650 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 452637011651 protein binding site [polypeptide binding]; other site 452637011652 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 452637011653 protein binding site [polypeptide binding]; other site 452637011654 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 452637011655 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 452637011656 protein binding site [polypeptide binding]; other site 452637011657 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 452637011658 protein binding site [polypeptide binding]; other site 452637011659 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 452637011660 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 452637011661 HIGH motif; other site 452637011662 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 452637011663 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452637011664 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452637011665 active site 452637011666 KMSKS motif; other site 452637011667 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 452637011668 tRNA binding surface [nucleotide binding]; other site 452637011669 FecR protein; Region: FecR; pfam04773 452637011670 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 452637011671 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 452637011672 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 452637011673 SLBB domain; Region: SLBB; pfam10531 452637011674 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 452637011675 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 452637011676 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 452637011677 P-loop; other site 452637011678 Magnesium ion binding site [ion binding]; other site 452637011679 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 452637011680 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 452637011681 Bifunctional nuclease; Region: DNase-RNase; pfam02577 452637011682 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 452637011683 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 452637011684 FMN binding site [chemical binding]; other site 452637011685 active site 452637011686 catalytic residues [active] 452637011687 substrate binding site [chemical binding]; other site 452637011688 Domain of unknown function DUF59; Region: DUF59; cl00941 452637011689 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 452637011690 tandem repeat interface [polypeptide binding]; other site 452637011691 oligomer interface [polypeptide binding]; other site 452637011692 active site residues [active] 452637011693 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 452637011694 tandem repeat interface [polypeptide binding]; other site 452637011695 oligomer interface [polypeptide binding]; other site 452637011696 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 452637011697 active site residues [active] 452637011698 diaminopimelate epimerase; Provisional; Region: PRK13577 452637011699 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 452637011700 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 452637011701 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 452637011702 putative catalytic residue [active] 452637011703 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 452637011704 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 452637011705 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 452637011706 exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178 452637011707 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 452637011708 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 452637011709 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 452637011710 active site 452637011711 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 452637011712 active site 452637011713 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 452637011714 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 452637011715 4Fe-4S binding domain; Region: Fer4_6; pfam12837 452637011716 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 452637011717 Ligand Binding Site [chemical binding]; other site 452637011718 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 452637011719 Electron transfer flavoprotein domain; Region: ETF; smart00893 452637011720 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 452637011721 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 452637011722 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 452637011723 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 452637011724 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 452637011725 putative active site [active] 452637011726 dimerization interface [polypeptide binding]; other site 452637011727 putative tRNAtyr binding site [nucleotide binding]; other site 452637011728 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 452637011729 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 452637011730 tetramer interface [polypeptide binding]; other site 452637011731 active site 452637011732 Mg2+/Mn2+ binding site [ion binding]; other site 452637011733 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 452637011734 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 452637011735 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 452637011736 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 452637011737 shikimate binding site; other site 452637011738 NAD(P) binding site [chemical binding]; other site 452637011739 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 452637011740 YWTD domain; Region: YWTD; pfam13570 452637011741 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 452637011742 active site 452637011743 Trp docking motif [polypeptide binding]; other site 452637011744 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 452637011745 transmembrane helices; other site 452637011746 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 452637011747 TrkA-C domain; Region: TrkA_C; pfam02080 452637011748 TrkA-C domain; Region: TrkA_C; pfam02080 452637011749 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 452637011750 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 452637011751 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 452637011752 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 452637011753 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 452637011754 active site 452637011755 metal binding site [ion binding]; metal-binding site 452637011756 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 452637011757 Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991 452637011758 active site 452637011759 classical (c) SDRs; Region: SDR_c; cd05233 452637011760 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 452637011761 NAD(P) binding site [chemical binding]; other site 452637011762 active site 452637011763 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 452637011764 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 452637011765 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 452637011766 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 452637011767 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 452637011768 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 452637011769 hypothetical protein; Reviewed; Region: PRK12497 452637011770 GAF domain; Region: GAF_2; pfam13185 452637011771 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 452637011772 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 452637011773 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 452637011774 Walker A motif; other site 452637011775 ATP binding site [chemical binding]; other site 452637011776 Walker B motif; other site 452637011777 Histidine kinase; Region: His_kinase; pfam06580 452637011778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637011779 ATP binding site [chemical binding]; other site 452637011780 Mg2+ binding site [ion binding]; other site 452637011781 G-X-G motif; other site 452637011782 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 452637011783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637011784 active site 452637011785 phosphorylation site [posttranslational modification] 452637011786 intermolecular recognition site; other site 452637011787 dimerization interface [polypeptide binding]; other site 452637011788 LytTr DNA-binding domain; Region: LytTR; smart00850 452637011789 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 452637011790 tellurite resistance protein TehB; Provisional; Region: PRK11207 452637011791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637011792 S-adenosylmethionine binding site [chemical binding]; other site 452637011793 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 452637011794 AAA domain; Region: AAA_23; pfam13476 452637011795 Walker A/P-loop; other site 452637011796 ATP binding site [chemical binding]; other site 452637011797 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 452637011798 ABC transporter signature motif; other site 452637011799 Walker B; other site 452637011800 D-loop; other site 452637011801 H-loop/switch region; other site 452637011802 putative acetyltransferase; Provisional; Region: PRK03624 452637011803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452637011804 Coenzyme A binding pocket [chemical binding]; other site 452637011805 putative transporter; Provisional; Region: PRK10504 452637011806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637011807 putative substrate translocation pore; other site 452637011808 FAD binding domain; Region: FAD_binding_4; pfam01565 452637011809 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 452637011810 Response regulator receiver domain; Region: Response_reg; pfam00072 452637011811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637011812 active site 452637011813 phosphorylation site [posttranslational modification] 452637011814 intermolecular recognition site; other site 452637011815 dimerization interface [polypeptide binding]; other site 452637011816 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637011817 dimer interface [polypeptide binding]; other site 452637011818 phosphorylation site [posttranslational modification] 452637011819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637011820 ATP binding site [chemical binding]; other site 452637011821 Mg2+ binding site [ion binding]; other site 452637011822 G-X-G motif; other site 452637011823 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637011824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637011825 active site 452637011826 phosphorylation site [posttranslational modification] 452637011827 intermolecular recognition site; other site 452637011828 dimerization interface [polypeptide binding]; other site 452637011829 Response regulator receiver domain; Region: Response_reg; pfam00072 452637011830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637011831 active site 452637011832 phosphorylation site [posttranslational modification] 452637011833 intermolecular recognition site; other site 452637011834 dimerization interface [polypeptide binding]; other site 452637011835 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 452637011836 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 452637011837 putative acyl-acceptor binding pocket; other site 452637011838 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452637011839 acyl-activating enzyme (AAE) consensus motif; other site 452637011840 AMP binding site [chemical binding]; other site 452637011841 active site 452637011842 CoA binding site [chemical binding]; other site 452637011843 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637011844 Walker A/P-loop; other site 452637011845 ATP binding site [chemical binding]; other site 452637011846 AAA domain; Region: AAA_21; pfam13304 452637011847 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 452637011848 putative transposase OrfB; Reviewed; Region: PHA02517 452637011849 DNA-binding interface [nucleotide binding]; DNA binding site 452637011850 Homeodomain-like domain; Region: HTH_32; pfam13565 452637011851 Integrase core domain; Region: rve; pfam00665 452637011852 Integrase core domain; Region: rve_3; cl15866 452637011853 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 452637011854 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 452637011855 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 452637011856 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 452637011857 Putative water exit pathway; other site 452637011858 Binuclear center (active site) [active] 452637011859 K-pathway; other site 452637011860 Putative proton exit pathway; other site 452637011861 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 452637011862 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 452637011863 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 452637011864 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 452637011865 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 452637011866 molybdopterin cofactor binding site; other site 452637011867 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 452637011868 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 452637011869 4Fe-4S binding domain; Region: Fer4_2; pfam12797 452637011870 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 452637011871 heme-binding residues [chemical binding]; other site 452637011872 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452637011873 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 452637011874 Walker A/P-loop; other site 452637011875 ATP binding site [chemical binding]; other site 452637011876 Q-loop/lid; other site 452637011877 ABC transporter signature motif; other site 452637011878 Walker B; other site 452637011879 D-loop; other site 452637011880 H-loop/switch region; other site 452637011881 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 452637011882 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637011883 FtsX-like permease family; Region: FtsX; pfam02687 452637011884 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 452637011885 HlyD family secretion protein; Region: HlyD_3; pfam13437 452637011886 Outer membrane efflux protein; Region: OEP; pfam02321 452637011887 Outer membrane efflux protein; Region: OEP; pfam02321 452637011888 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 452637011889 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 452637011890 NADP-binding site; other site 452637011891 homotetramer interface [polypeptide binding]; other site 452637011892 substrate binding site [chemical binding]; other site 452637011893 homodimer interface [polypeptide binding]; other site 452637011894 active site 452637011895 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 452637011896 ligand-binding site [chemical binding]; other site 452637011897 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 452637011898 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 452637011899 Active Sites [active] 452637011900 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 452637011901 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 452637011902 CysD dimerization site [polypeptide binding]; other site 452637011903 G1 box; other site 452637011904 putative GEF interaction site [polypeptide binding]; other site 452637011905 GTP/Mg2+ binding site [chemical binding]; other site 452637011906 Switch I region; other site 452637011907 G2 box; other site 452637011908 G3 box; other site 452637011909 Switch II region; other site 452637011910 G4 box; other site 452637011911 G5 box; other site 452637011912 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 452637011913 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 452637011914 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 452637011915 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 452637011916 NADP-binding site; other site 452637011917 homotetramer interface [polypeptide binding]; other site 452637011918 substrate binding site [chemical binding]; other site 452637011919 homodimer interface [polypeptide binding]; other site 452637011920 active site 452637011921 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 452637011922 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 452637011923 Methyltransferase domain; Region: Methyltransf_11; pfam08241 452637011924 Methyltransferase domain; Region: Methyltransf_23; pfam13489 452637011925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637011926 S-adenosylmethionine binding site [chemical binding]; other site 452637011927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637011928 S-adenosylmethionine binding site [chemical binding]; other site 452637011929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452637011930 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 452637011931 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 452637011932 putative active site [active] 452637011933 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 452637011934 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 452637011935 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452637011936 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637011937 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 452637011938 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 452637011939 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 452637011940 metal-binding site 452637011941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452637011942 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 452637011943 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 452637011944 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 452637011945 metal-binding site 452637011946 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 452637011947 putative active site [active] 452637011948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637011949 TPR motif; other site 452637011950 binding surface 452637011951 Tetratricopeptide repeat; Region: TPR_16; pfam13432 452637011952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637011953 binding surface 452637011954 TPR motif; other site 452637011955 TPR repeat; Region: TPR_11; pfam13414 452637011956 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637011957 binding surface 452637011958 TPR repeat; Region: TPR_11; pfam13414 452637011959 TPR motif; other site 452637011960 Tetratricopeptide repeat; Region: TPR_16; pfam13432 452637011961 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 452637011962 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 452637011963 Methyltransferase domain; Region: Methyltransf_23; pfam13489 452637011964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637011965 S-adenosylmethionine binding site [chemical binding]; other site 452637011966 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 452637011967 Methyltransferase domain; Region: Methyltransf_31; pfam13847 452637011968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637011969 S-adenosylmethionine binding site [chemical binding]; other site 452637011970 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 452637011971 Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797 452637011972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 452637011973 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637011974 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 452637011975 putative ADP-binding pocket [chemical binding]; other site 452637011976 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 452637011977 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 452637011978 Walker A/P-loop; other site 452637011979 ATP binding site [chemical binding]; other site 452637011980 Q-loop/lid; other site 452637011981 ABC transporter signature motif; other site 452637011982 Walker B; other site 452637011983 D-loop; other site 452637011984 H-loop/switch region; other site 452637011985 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 452637011986 putative carbohydrate binding site [chemical binding]; other site 452637011987 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637011988 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637011989 DNA binding residues [nucleotide binding] 452637011990 dimerization interface [polypeptide binding]; other site 452637011991 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 452637011992 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 452637011993 active site 452637011994 putative substrate binding region [chemical binding]; other site 452637011995 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 452637011996 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 452637011997 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 452637011998 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 452637011999 HlyD family secretion protein; Region: HlyD_3; pfam13437 452637012000 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 452637012001 HlyD family secretion protein; Region: HlyD_3; pfam13437 452637012002 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452637012003 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 452637012004 active site 452637012005 nucleotide binding site [chemical binding]; other site 452637012006 HIGH motif; other site 452637012007 KMSKS motif; other site 452637012008 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 452637012009 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 452637012010 putative ribose interaction site [chemical binding]; other site 452637012011 putative ADP binding site [chemical binding]; other site 452637012012 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637012013 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452637012014 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 452637012015 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 452637012016 Probable Catalytic site; other site 452637012017 metal-binding site 452637012018 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 452637012019 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 452637012020 Probable Catalytic site; other site 452637012021 metal-binding site 452637012022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637012023 S-adenosylmethionine binding site [chemical binding]; other site 452637012024 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452637012025 UDP-glucose 4 epimerase, subgroup 2, extended (e) SDRs; Region: UDP_G4E_2_SDR_e; cd05234 452637012026 NAD binding site [chemical binding]; other site 452637012027 homodimer interface [polypeptide binding]; other site 452637012028 active site 452637012029 putative substrate binding site [chemical binding]; other site 452637012030 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 452637012031 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 452637012032 Ligand binding site; other site 452637012033 Putative Catalytic site; other site 452637012034 DXD motif; other site 452637012035 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 452637012036 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 452637012037 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 452637012038 Substrate binding site; other site 452637012039 Mg++ binding site; other site 452637012040 metal-binding site 452637012041 Mg++ binding site; other site 452637012042 metal-binding site 452637012043 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 452637012044 dimer interface [polypeptide binding]; other site 452637012045 active site 452637012046 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 452637012047 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452637012048 active site 452637012049 motif I; other site 452637012050 motif II; other site 452637012051 putative translaldolase; Provisional; Region: PRK12376 452637012052 catalytic residue [active] 452637012053 Methyltransferase domain; Region: Methyltransf_23; pfam13489 452637012054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637012055 S-adenosylmethionine binding site [chemical binding]; other site 452637012056 Methyltransferase domain; Region: Methyltransf_23; pfam13489 452637012057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637012058 S-adenosylmethionine binding site [chemical binding]; other site 452637012059 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 452637012060 Ligand binding site; other site 452637012061 Putative Catalytic site; other site 452637012062 DXD motif; other site 452637012063 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452637012064 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 452637012065 NAD binding site [chemical binding]; other site 452637012066 homotetramer interface [polypeptide binding]; other site 452637012067 homodimer interface [polypeptide binding]; other site 452637012068 active site 452637012069 substrate binding site [chemical binding]; other site 452637012070 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 452637012071 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 452637012072 active site 452637012073 active site 452637012074 Immunoglobulin domain; Region: Ig_3; pfam13927 452637012075 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 452637012076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452637012077 NAD(P) binding site [chemical binding]; other site 452637012078 active site 452637012079 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 452637012080 Ligand binding site; other site 452637012081 Putative Catalytic site; other site 452637012082 DXD motif; other site 452637012083 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 452637012084 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 452637012085 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 452637012086 NADP binding site [chemical binding]; other site 452637012087 active site 452637012088 putative substrate binding site [chemical binding]; other site 452637012089 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 452637012090 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 452637012091 NAD binding site [chemical binding]; other site 452637012092 substrate binding site [chemical binding]; other site 452637012093 homodimer interface [polypeptide binding]; other site 452637012094 active site 452637012095 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 452637012096 four helix bundle protein; Region: TIGR02436 452637012097 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 452637012098 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 452637012099 substrate binding site; other site 452637012100 tetramer interface; other site 452637012101 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 452637012102 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 452637012103 Probable Catalytic site; other site 452637012104 metal-binding site 452637012105 DinB superfamily; Region: DinB_2; pfam12867 452637012106 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 452637012107 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 452637012108 Ligand binding site; other site 452637012109 Putative Catalytic site; other site 452637012110 DXD motif; other site 452637012111 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 452637012112 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 452637012113 inhibitor-cofactor binding pocket; inhibition site 452637012114 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637012115 catalytic residue [active] 452637012116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637012117 S-adenosylmethionine binding site [chemical binding]; other site 452637012118 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452637012119 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637012120 Methyltransferase domain; Region: Methyltransf_23; pfam13489 452637012121 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 452637012122 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637012123 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452637012124 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637012125 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 452637012126 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 452637012127 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 452637012128 catalytic residue [active] 452637012129 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452637012130 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637012131 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637012132 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 452637012133 putative ADP-binding pocket [chemical binding]; other site 452637012134 monogalactosyldiacylglycerol synthase; Region: PLN02605 452637012135 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 452637012136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452637012137 NAD(P) binding site [chemical binding]; other site 452637012138 active site 452637012139 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 452637012140 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 452637012141 dimer interface [polypeptide binding]; other site 452637012142 active site 452637012143 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 452637012144 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 452637012145 active site 2 [active] 452637012146 active site 1 [active] 452637012147 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637012148 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 452637012149 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 452637012150 active site 452637012151 epoxyqueuosine reductase; Region: TIGR00276 452637012152 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 452637012153 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 452637012154 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 452637012155 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 452637012156 ADP binding site [chemical binding]; other site 452637012157 magnesium binding site [ion binding]; other site 452637012158 putative shikimate binding site; other site 452637012159 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 452637012160 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 452637012161 tetramer interface [polypeptide binding]; other site 452637012162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637012163 catalytic residue [active] 452637012164 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 452637012165 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 452637012166 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 452637012167 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 452637012168 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 452637012169 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 452637012170 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452637012171 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 452637012172 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 452637012173 Low molecular weight phosphatase family; Region: LMWPc; cd00115 452637012174 active site 452637012175 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 452637012176 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 452637012177 dimer interface [polypeptide binding]; other site 452637012178 active site 452637012179 glycine-pyridoxal phosphate binding site [chemical binding]; other site 452637012180 folate binding site [chemical binding]; other site 452637012181 CHASE domain; Region: CHASE; pfam03924 452637012182 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 452637012183 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637012184 putative active site [active] 452637012185 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637012186 heme pocket [chemical binding]; other site 452637012187 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637012188 dimer interface [polypeptide binding]; other site 452637012189 phosphorylation site [posttranslational modification] 452637012190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637012191 ATP binding site [chemical binding]; other site 452637012192 Mg2+ binding site [ion binding]; other site 452637012193 G-X-G motif; other site 452637012194 Response regulator receiver domain; Region: Response_reg; pfam00072 452637012195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637012196 active site 452637012197 phosphorylation site [posttranslational modification] 452637012198 intermolecular recognition site; other site 452637012199 dimerization interface [polypeptide binding]; other site 452637012200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637012201 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452637012202 putative substrate translocation pore; other site 452637012203 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 452637012204 catalytic motif [active] 452637012205 Catalytic residue [active] 452637012206 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 452637012207 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 452637012208 NusB family; Region: NusB; pfam01029 452637012209 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 452637012210 transcription elongation factor GreA; Region: greA; TIGR01462 452637012211 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 452637012212 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 452637012213 LysE type translocator; Region: LysE; cl00565 452637012214 Tic20-like protein; Region: Tic20; pfam09685 452637012215 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452637012216 dimerization interface [polypeptide binding]; other site 452637012217 putative DNA binding site [nucleotide binding]; other site 452637012218 putative Zn2+ binding site [ion binding]; other site 452637012219 Methyltransferase domain; Region: Methyltransf_31; pfam13847 452637012220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637012221 S-adenosylmethionine binding site [chemical binding]; other site 452637012222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 452637012223 Predicted membrane protein [Function unknown]; Region: COG2510 452637012224 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 452637012225 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 452637012226 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 452637012227 trimer interface [polypeptide binding]; other site 452637012228 putative metal binding site [ion binding]; other site 452637012229 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 452637012230 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 452637012231 Nucleoside recognition; Region: Gate; pfam07670 452637012232 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 452637012233 Protein of unknown function (DUF1318); Region: DUF1318; cl01547 452637012234 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 452637012235 Dicarboxylate transport; Region: DctA-YdbH; cl14674 452637012236 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 452637012237 homodimer interface [polypeptide binding]; other site 452637012238 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 452637012239 active site pocket [active] 452637012240 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 452637012241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637012242 ATP binding site [chemical binding]; other site 452637012243 Mg2+ binding site [ion binding]; other site 452637012244 G-X-G motif; other site 452637012245 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 452637012246 ATP binding site [chemical binding]; other site 452637012247 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 452637012248 argininosuccinate lyase; Provisional; Region: PRK00855 452637012249 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 452637012250 active sites [active] 452637012251 tetramer interface [polypeptide binding]; other site 452637012252 OsmC-like protein; Region: OsmC; pfam02566 452637012253 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 452637012254 ABC1 family; Region: ABC1; cl17513 452637012255 OsmC-like protein; Region: OsmC; cl00767 452637012256 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 452637012257 Fe-S cluster binding site [ion binding]; other site 452637012258 active site 452637012259 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 452637012260 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 452637012261 putative active site [active] 452637012262 putative PHP Thumb interface [polypeptide binding]; other site 452637012263 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 452637012264 generic binding surface II; other site 452637012265 generic binding surface I; other site 452637012266 active site 452637012267 Y-family of DNA polymerases; Region: PolY; cl12025 452637012268 Y-family of DNA polymerases; Region: PolY; cl12025 452637012269 DNA binding site [nucleotide binding] 452637012270 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 452637012271 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452637012272 Walker A motif; other site 452637012273 ATP binding site [chemical binding]; other site 452637012274 Walker B motif; other site 452637012275 LexA repressor; Validated; Region: PRK00215 452637012276 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 452637012277 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 452637012278 Catalytic site [active] 452637012279 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 452637012280 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637012281 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637012282 DNA binding residues [nucleotide binding] 452637012283 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 452637012284 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 452637012285 catalytic residues [active] 452637012286 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 452637012287 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 452637012288 Predicted permeases [General function prediction only]; Region: COG0701 452637012289 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452637012290 dimerization interface [polypeptide binding]; other site 452637012291 putative DNA binding site [nucleotide binding]; other site 452637012292 putative Zn2+ binding site [ion binding]; other site 452637012293 Tic20-like protein; Region: Tic20; pfam09685 452637012294 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 452637012295 substrate binding site [chemical binding]; other site 452637012296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 452637012297 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 452637012298 Putative glucoamylase; Region: Glycoamylase; pfam10091 452637012299 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_4; cd09619 452637012300 putative ligand binding site [chemical binding]; other site 452637012301 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637012302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637012303 ATP binding site [chemical binding]; other site 452637012304 Mg2+ binding site [ion binding]; other site 452637012305 G-X-G motif; other site 452637012306 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 452637012307 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 452637012308 PLD-like domain; Region: PLDc_2; pfam13091 452637012309 putative active site [active] 452637012310 catalytic site [active] 452637012311 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 452637012312 PLD-like domain; Region: PLDc_2; pfam13091 452637012313 putative active site [active] 452637012314 catalytic site [active] 452637012315 Sensory domain found in PocR; Region: PocR; pfam10114 452637012316 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 452637012317 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 452637012318 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637012319 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637012320 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 452637012321 cbb3-type cytochrome c oxidase subunit I; Provisional; Region: PRK14488 452637012322 Low-spin heme binding site [chemical binding]; other site 452637012323 D-pathway; other site 452637012324 Putative water exit pathway; other site 452637012325 Binuclear center (active site) [active] 452637012326 K-pathway; other site 452637012327 Putative proton exit pathway; other site 452637012328 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 452637012329 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 452637012330 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 452637012331 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 452637012332 4Fe-4S binding domain; Region: Fer4_5; pfam12801 452637012333 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 452637012334 Family description; Region: DsbD_2; pfam13386 452637012335 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 452637012336 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 452637012337 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 452637012338 metal-binding site [ion binding] 452637012339 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 452637012340 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 452637012341 Ligand Binding Site [chemical binding]; other site 452637012342 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 452637012343 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 452637012344 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 452637012345 active site 452637012346 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 452637012347 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 452637012348 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 452637012349 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 452637012350 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 452637012351 Class I aldolases; Region: Aldolase_Class_I; cl17187 452637012352 catalytic residue [active] 452637012353 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 452637012354 pyruvate phosphate dikinase; Provisional; Region: PRK09279 452637012355 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 452637012356 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 452637012357 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 452637012358 putative pectinesterase; Region: PLN02432; cl01911 452637012359 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 452637012360 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 452637012361 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 452637012362 Major royal jelly protein; Region: MRJP; pfam03022 452637012363 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 452637012364 Sodium Bile acid symporter family; Region: SBF; pfam01758 452637012365 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 452637012366 Na binding site [ion binding]; other site 452637012367 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 452637012368 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 452637012369 dimer interface [polypeptide binding]; other site 452637012370 putative CheW interface [polypeptide binding]; other site 452637012371 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 452637012372 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 452637012373 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 452637012374 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 452637012375 putative dimer interface [polypeptide binding]; other site 452637012376 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452637012377 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 452637012378 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 452637012379 active site 452637012380 Predicted transcriptional regulator [Transcription]; Region: COG2378 452637012381 WYL domain; Region: WYL; pfam13280 452637012382 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 452637012383 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 452637012384 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 452637012385 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 452637012386 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 452637012387 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 452637012388 structural tetrad; other site 452637012389 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637012390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637012391 active site 452637012392 phosphorylation site [posttranslational modification] 452637012393 intermolecular recognition site; other site 452637012394 dimerization interface [polypeptide binding]; other site 452637012395 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 452637012396 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 452637012397 HflX GTPase family; Region: HflX; cd01878 452637012398 G1 box; other site 452637012399 GTP/Mg2+ binding site [chemical binding]; other site 452637012400 Switch I region; other site 452637012401 G2 box; other site 452637012402 G3 box; other site 452637012403 Switch II region; other site 452637012404 G4 box; other site 452637012405 G5 box; other site 452637012406 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 452637012407 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 452637012408 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 452637012409 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 452637012410 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 452637012411 NADH dehydrogenase; Region: NADHdh; cl00469 452637012412 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 452637012413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452637012414 Coenzyme A binding pocket [chemical binding]; other site 452637012415 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 452637012416 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 452637012417 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 452637012418 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 452637012419 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 452637012420 TPR repeat; Region: TPR_11; pfam13414 452637012421 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637012422 binding surface 452637012423 TPR motif; other site 452637012424 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637012425 TPR motif; other site 452637012426 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 452637012427 active site 452637012428 DNA binding site [nucleotide binding] 452637012429 Int/Topo IB signature motif; other site 452637012430 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 452637012431 active site 452637012432 GIY-YIG motif/motif A; other site 452637012433 catalytic site [active] 452637012434 metal binding site [ion binding]; metal-binding site 452637012435 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 452637012436 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 452637012437 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 452637012438 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 452637012439 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 452637012440 dimerization interface [polypeptide binding]; other site 452637012441 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 452637012442 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 452637012443 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637012444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637012445 ATP binding site [chemical binding]; other site 452637012446 Mg2+ binding site [ion binding]; other site 452637012447 G-X-G motif; other site 452637012448 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637012449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637012450 active site 452637012451 phosphorylation site [posttranslational modification] 452637012452 intermolecular recognition site; other site 452637012453 dimerization interface [polypeptide binding]; other site 452637012454 PAS domain S-box; Region: sensory_box; TIGR00229 452637012455 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637012456 putative active site [active] 452637012457 heme pocket [chemical binding]; other site 452637012458 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637012459 dimer interface [polypeptide binding]; other site 452637012460 phosphorylation site [posttranslational modification] 452637012461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637012462 ATP binding site [chemical binding]; other site 452637012463 Mg2+ binding site [ion binding]; other site 452637012464 G-X-G motif; other site 452637012465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637012466 active site 452637012467 phosphorylation site [posttranslational modification] 452637012468 intermolecular recognition site; other site 452637012469 phytoene desaturase; Region: phytoene_desat; TIGR02731 452637012470 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 452637012471 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 452637012472 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 452637012473 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 452637012474 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 452637012475 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 452637012476 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 452637012477 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 452637012478 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 452637012479 active site 452637012480 DNA binding site [nucleotide binding] 452637012481 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 452637012482 DNA binding site [nucleotide binding] 452637012483 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 452637012484 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 452637012485 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 452637012486 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 452637012487 Coenzyme A binding pocket [chemical binding]; other site 452637012488 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 452637012489 GAF domain; Region: GAF_2; pfam13185 452637012490 GAF domain; Region: GAF; pfam01590 452637012491 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 452637012492 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 452637012493 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 452637012494 putative molybdopterin cofactor binding site [chemical binding]; other site 452637012495 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 452637012496 putative molybdopterin cofactor binding site; other site 452637012497 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 452637012498 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 452637012499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452637012500 dimer interface [polypeptide binding]; other site 452637012501 conserved gate region; other site 452637012502 putative PBP binding loops; other site 452637012503 ABC-ATPase subunit interface; other site 452637012504 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 452637012505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 452637012506 dimer interface [polypeptide binding]; other site 452637012507 conserved gate region; other site 452637012508 putative PBP binding loops; other site 452637012509 ABC-ATPase subunit interface; other site 452637012510 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 452637012511 putative nucleotide binding site [chemical binding]; other site 452637012512 uridine monophosphate binding site [chemical binding]; other site 452637012513 homohexameric interface [polypeptide binding]; other site 452637012514 ribosome recycling factor; Reviewed; Region: frr; PRK00083 452637012515 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 452637012516 hinge region; other site 452637012517 gamma-glutamyl kinase; Provisional; Region: PRK05429 452637012518 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 452637012519 nucleotide binding site [chemical binding]; other site 452637012520 homotetrameric interface [polypeptide binding]; other site 452637012521 putative phosphate binding site [ion binding]; other site 452637012522 putative allosteric binding site; other site 452637012523 PUA domain; Region: PUA; pfam01472 452637012524 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 452637012525 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637012526 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 452637012527 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452637012528 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452637012529 Coenzyme A binding pocket [chemical binding]; other site 452637012530 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 452637012531 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 452637012532 active site 452637012533 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 452637012534 Part of AAA domain; Region: AAA_19; pfam13245 452637012535 Family description; Region: UvrD_C_2; pfam13538 452637012536 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 452637012537 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637012538 FtsX-like permease family; Region: FtsX; pfam02687 452637012539 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 452637012540 FtsX-like permease family; Region: FtsX; pfam02687 452637012541 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 452637012542 hypothetical protein; Provisional; Region: PRK00955 452637012543 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 452637012544 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 452637012545 PAS domain S-box; Region: sensory_box; TIGR00229 452637012546 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637012547 putative active site [active] 452637012548 heme pocket [chemical binding]; other site 452637012549 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637012550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637012551 ATP binding site [chemical binding]; other site 452637012552 Mg2+ binding site [ion binding]; other site 452637012553 G-X-G motif; other site 452637012554 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452637012555 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637012556 DNA binding residues [nucleotide binding] 452637012557 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 452637012558 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 452637012559 Metal-binding active site; metal-binding site 452637012560 AP (apurinic/apyrimidinic) site pocket; other site 452637012561 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 452637012562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 452637012563 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452637012564 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 452637012565 metal binding site 2 [ion binding]; metal-binding site 452637012566 putative DNA binding helix; other site 452637012567 metal binding site 1 [ion binding]; metal-binding site 452637012568 dimer interface [polypeptide binding]; other site 452637012569 structural Zn2+ binding site [ion binding]; other site 452637012570 FeS assembly ATPase SufC; Region: sufC; TIGR01978 452637012571 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 452637012572 Walker A/P-loop; other site 452637012573 ATP binding site [chemical binding]; other site 452637012574 Q-loop/lid; other site 452637012575 ABC transporter signature motif; other site 452637012576 Walker B; other site 452637012577 D-loop; other site 452637012578 H-loop/switch region; other site 452637012579 FeS assembly protein SufB; Region: sufB; TIGR01980 452637012580 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 452637012581 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 452637012582 FeS assembly protein SufD; Region: sufD; TIGR01981 452637012583 Domain of unknown function DUF59; Region: DUF59; cl00941 452637012584 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637012585 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637012586 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 452637012587 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 452637012588 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 452637012589 DNA binding residues [nucleotide binding] 452637012590 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 452637012591 Catalytic domain of Protein Kinases; Region: PKc; cd00180 452637012592 active site 452637012593 ATP binding site [chemical binding]; other site 452637012594 substrate binding site [chemical binding]; other site 452637012595 activation loop (A-loop); other site 452637012596 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452637012597 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452637012598 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452637012599 Tetratricopeptide repeat; Region: TPR_10; pfam13374 452637012600 Tetratricopeptide repeat; Region: TPR_10; pfam13374 452637012601 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452637012602 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637012603 binding surface 452637012604 TPR motif; other site 452637012605 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452637012606 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637012607 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637012608 DNA binding residues [nucleotide binding] 452637012609 2-isopropylmalate synthase; Validated; Region: PRK03739 452637012610 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 452637012611 active site 452637012612 catalytic residues [active] 452637012613 metal binding site [ion binding]; metal-binding site 452637012614 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 452637012615 Low affinity iron permease; Region: Iron_permease; pfam04120 452637012616 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 452637012617 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 452637012618 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452637012619 FeS/SAM binding site; other site 452637012620 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 452637012621 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 452637012622 Walker A/P-loop; other site 452637012623 ATP binding site [chemical binding]; other site 452637012624 Q-loop/lid; other site 452637012625 ABC transporter signature motif; other site 452637012626 Walker B; other site 452637012627 D-loop; other site 452637012628 H-loop/switch region; other site 452637012629 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 452637012630 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 452637012631 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 452637012632 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 452637012633 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 452637012634 FAD binding site [chemical binding]; other site 452637012635 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 452637012636 putative rRNA binding site [nucleotide binding]; other site 452637012637 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 452637012638 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 452637012639 TPP-binding site [chemical binding]; other site 452637012640 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 452637012641 dimer interface [polypeptide binding]; other site 452637012642 PYR/PP interface [polypeptide binding]; other site 452637012643 TPP binding site [chemical binding]; other site 452637012644 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 452637012645 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 452637012646 E3 interaction surface; other site 452637012647 lipoyl attachment site [posttranslational modification]; other site 452637012648 e3 binding domain; Region: E3_binding; pfam02817 452637012649 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 452637012650 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 452637012651 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 452637012652 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 452637012653 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 452637012654 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 452637012655 EamA-like transporter family; Region: EamA; pfam00892 452637012656 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 452637012657 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 452637012658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452637012659 motif II; other site 452637012660 BNR repeat-like domain; Region: BNR_2; pfam13088 452637012661 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 452637012662 Predicted esterase [General function prediction only]; Region: COG0400 452637012663 putative hydrolase; Provisional; Region: PRK11460 452637012664 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 452637012665 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 452637012666 active site 452637012667 catalytic tetrad [active] 452637012668 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 452637012669 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 452637012670 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 452637012671 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637012672 DNA binding residues [nucleotide binding] 452637012673 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 452637012674 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 452637012675 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 452637012676 tetramer interface [polypeptide binding]; other site 452637012677 TPP-binding site [chemical binding]; other site 452637012678 heterodimer interface [polypeptide binding]; other site 452637012679 phosphorylation loop region [posttranslational modification] 452637012680 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 452637012681 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 452637012682 alpha subunit interface [polypeptide binding]; other site 452637012683 TPP binding site [chemical binding]; other site 452637012684 heterodimer interface [polypeptide binding]; other site 452637012685 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 452637012686 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 452637012687 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 452637012688 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 452637012689 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 452637012690 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 452637012691 Walker A/P-loop; other site 452637012692 ATP binding site [chemical binding]; other site 452637012693 Q-loop/lid; other site 452637012694 ABC transporter signature motif; other site 452637012695 Walker B; other site 452637012696 D-loop; other site 452637012697 H-loop/switch region; other site 452637012698 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 452637012699 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 452637012700 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 452637012701 Hpr binding site; other site 452637012702 active site 452637012703 homohexamer subunit interaction site [polypeptide binding]; other site 452637012704 ribonuclease PH; Reviewed; Region: rph; PRK00173 452637012705 Ribonuclease PH; Region: RNase_PH_bact; cd11362 452637012706 hexamer interface [polypeptide binding]; other site 452637012707 active site 452637012708 UreD urease accessory protein; Region: UreD; pfam01774 452637012709 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 452637012710 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 452637012711 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 452637012712 UreF; Region: UreF; pfam01730 452637012713 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727 452637012714 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 452637012715 dimer interface [polypeptide binding]; other site 452637012716 catalytic residues [active] 452637012717 hypothetical protein; Provisional; Region: PRK02250 452637012718 glutamate racemase; Provisional; Region: PRK00865 452637012719 N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067 452637012720 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 452637012721 MFS/sugar transport protein; Region: MFS_2; pfam13347 452637012722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637012723 putative substrate translocation pore; other site 452637012724 urease subunit alpha; Reviewed; Region: ureC; PRK13207 452637012725 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 452637012726 subunit interactions [polypeptide binding]; other site 452637012727 active site 452637012728 flap region; other site 452637012729 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 452637012730 gamma-beta subunit interface [polypeptide binding]; other site 452637012731 alpha-beta subunit interface [polypeptide binding]; other site 452637012732 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 452637012733 alpha-gamma subunit interface [polypeptide binding]; other site 452637012734 beta-gamma subunit interface [polypeptide binding]; other site 452637012735 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 452637012736 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 452637012737 Walker A/P-loop; other site 452637012738 ATP binding site [chemical binding]; other site 452637012739 Q-loop/lid; other site 452637012740 ABC transporter signature motif; other site 452637012741 Walker B; other site 452637012742 D-loop; other site 452637012743 H-loop/switch region; other site 452637012744 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 452637012745 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 452637012746 Walker A/P-loop; other site 452637012747 ATP binding site [chemical binding]; other site 452637012748 Q-loop/lid; other site 452637012749 ABC transporter signature motif; other site 452637012750 Walker B; other site 452637012751 D-loop; other site 452637012752 H-loop/switch region; other site 452637012753 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 452637012754 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 452637012755 TM-ABC transporter signature motif; other site 452637012756 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 452637012757 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 452637012758 TM-ABC transporter signature motif; other site 452637012759 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 452637012760 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 452637012761 putative ligand binding site [chemical binding]; other site 452637012762 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 452637012763 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 452637012764 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 452637012765 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 452637012766 CoA-ligase; Region: Ligase_CoA; pfam00549 452637012767 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 452637012768 CoA binding domain; Region: CoA_binding; pfam02629 452637012769 CoA-ligase; Region: Ligase_CoA; pfam00549 452637012770 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452637012771 Walker A motif; other site 452637012772 ATP binding site [chemical binding]; other site 452637012773 Walker B motif; other site 452637012774 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 452637012775 Sel1-like repeats; Region: SEL1; smart00671 452637012776 Sel1-like repeats; Region: SEL1; smart00671 452637012777 Sel1-like repeats; Region: SEL1; smart00671 452637012778 Sel1-like repeats; Region: SEL1; smart00671 452637012779 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 452637012780 peptide chain release factor 2; Provisional; Region: PRK05589 452637012781 This domain is found in peptide chain release factors; Region: PCRF; smart00937 452637012782 RF-1 domain; Region: RF-1; pfam00472 452637012783 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 452637012784 active site 452637012785 ATP binding site [chemical binding]; other site 452637012786 substrate binding site [chemical binding]; other site 452637012787 activation loop (A-loop); other site 452637012788 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 452637012789 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 452637012790 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 452637012791 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 452637012792 NADP binding site [chemical binding]; other site 452637012793 active site 452637012794 putative substrate binding site [chemical binding]; other site 452637012795 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 452637012796 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 452637012797 NADP-binding site; other site 452637012798 homotetramer interface [polypeptide binding]; other site 452637012799 substrate binding site [chemical binding]; other site 452637012800 homodimer interface [polypeptide binding]; other site 452637012801 active site 452637012802 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 452637012803 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 452637012804 NAD(P) binding site [chemical binding]; other site 452637012805 catalytic residues [active] 452637012806 YcaO-like family; Region: YcaO; pfam02624 452637012807 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 452637012808 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 452637012809 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637012810 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637012811 dimer interface [polypeptide binding]; other site 452637012812 phosphorylation site [posttranslational modification] 452637012813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637012814 ATP binding site [chemical binding]; other site 452637012815 Mg2+ binding site [ion binding]; other site 452637012816 G-X-G motif; other site 452637012817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637012818 Response regulator receiver domain; Region: Response_reg; pfam00072 452637012819 active site 452637012820 phosphorylation site [posttranslational modification] 452637012821 intermolecular recognition site; other site 452637012822 dimerization interface [polypeptide binding]; other site 452637012823 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637012824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637012825 active site 452637012826 phosphorylation site [posttranslational modification] 452637012827 intermolecular recognition site; other site 452637012828 dimerization interface [polypeptide binding]; other site 452637012829 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637012830 DNA binding residues [nucleotide binding] 452637012831 dimerization interface [polypeptide binding]; other site 452637012832 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 452637012833 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 452637012834 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 452637012835 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 452637012836 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 452637012837 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 452637012838 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 452637012839 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 452637012840 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 452637012841 Interdomain contacts; other site 452637012842 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 452637012843 PAS domain; Region: PAS_9; pfam13426 452637012844 putative active site [active] 452637012845 heme pocket [chemical binding]; other site 452637012846 Histidine kinase; Region: HisKA_3; pfam07730 452637012847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637012848 ATP binding site [chemical binding]; other site 452637012849 Mg2+ binding site [ion binding]; other site 452637012850 G-X-G motif; other site 452637012851 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637012852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637012853 active site 452637012854 phosphorylation site [posttranslational modification] 452637012855 intermolecular recognition site; other site 452637012856 dimerization interface [polypeptide binding]; other site 452637012857 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637012858 DNA binding residues [nucleotide binding] 452637012859 dimerization interface [polypeptide binding]; other site 452637012860 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 452637012861 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 452637012862 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 452637012863 Phage Tail Collar Domain; Region: Collar; pfam07484 452637012864 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452637012865 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 452637012866 Methyltransferase domain; Region: Methyltransf_31; pfam13847 452637012867 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 452637012868 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 452637012869 substrate binding site [chemical binding]; other site 452637012870 ATP binding site [chemical binding]; other site 452637012871 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 452637012872 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 452637012873 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 452637012874 putative ligand binding site [chemical binding]; other site 452637012875 putative NAD binding site [chemical binding]; other site 452637012876 catalytic site [active] 452637012877 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 452637012878 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 452637012879 active site 452637012880 intersubunit interface [polypeptide binding]; other site 452637012881 catalytic residue [active] 452637012882 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 452637012883 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 452637012884 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 452637012885 NADP binding site [chemical binding]; other site 452637012886 homodimer interface [polypeptide binding]; other site 452637012887 active site 452637012888 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637012889 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637012890 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452637012891 DNA binding site [nucleotide binding] 452637012892 domain linker motif; other site 452637012893 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 452637012894 Periplasmic binding protein-like domain; Region: Peripla_BP_3; pfam13377 452637012895 N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067 452637012896 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 452637012897 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 452637012898 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 452637012899 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 452637012900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637012901 Major Facilitator Superfamily; Region: MFS_1; pfam07690 452637012902 putative substrate translocation pore; other site 452637012903 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 452637012904 putative transposase OrfB; Reviewed; Region: PHA02517 452637012905 DNA-binding interface [nucleotide binding]; DNA binding site 452637012906 Homeodomain-like domain; Region: HTH_32; pfam13565 452637012907 Integrase core domain; Region: rve; pfam00665 452637012908 Integrase core domain; Region: rve_3; cl15866 452637012909 Pectinesterase; Region: Pectinesterase; pfam01095 452637012910 putative pectinesterase; Region: PLN02432; cl01911 452637012911 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 452637012912 active site 452637012913 catalytic triad [active] 452637012914 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 452637012915 MarR family; Region: MarR_2; pfam12802 452637012916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637012917 S-adenosylmethionine binding site [chemical binding]; other site 452637012918 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 452637012919 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 452637012920 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637012921 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452637012922 DNA binding site [nucleotide binding] 452637012923 domain linker motif; other site 452637012924 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 452637012925 ligand binding site [chemical binding]; other site 452637012926 dimerization interface [polypeptide binding]; other site 452637012927 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 452637012928 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 452637012929 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 452637012930 Pectate lyase; Region: Pec_lyase_C; cl01593 452637012931 Tetratricopeptide repeat; Region: TPR_12; pfam13424 452637012932 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637012933 TPR motif; other site 452637012934 binding surface 452637012935 TPR repeat; Region: TPR_11; pfam13414 452637012936 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637012937 binding surface 452637012938 TPR motif; other site 452637012939 TPR repeat; Region: TPR_11; pfam13414 452637012940 TPR repeat; Region: TPR_11; pfam13414 452637012941 TPR repeat; Region: TPR_11; pfam13414 452637012942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637012943 binding surface 452637012944 TPR motif; other site 452637012945 Tetratricopeptide repeat; Region: TPR_16; pfam13432 452637012946 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 452637012947 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452637012948 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637012949 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452637012950 DNA binding site [nucleotide binding] 452637012951 domain linker motif; other site 452637012952 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 452637012953 dimerization interface [polypeptide binding]; other site 452637012954 ligand binding site [chemical binding]; other site 452637012955 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 452637012956 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 452637012957 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637012958 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452637012959 DNA binding site [nucleotide binding] 452637012960 domain linker motif; other site 452637012961 Periplasmic binding protein-like domain; Region: Peripla_BP_3; pfam13377 452637012962 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 452637012963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637012964 D-galactonate transporter; Region: 2A0114; TIGR00893 452637012965 putative substrate translocation pore; other site 452637012966 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 452637012967 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 452637012968 active site 452637012969 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 452637012970 putative transposase OrfB; Reviewed; Region: PHA02517 452637012971 DNA-binding interface [nucleotide binding]; DNA binding site 452637012972 Homeodomain-like domain; Region: HTH_32; pfam13565 452637012973 Integrase core domain; Region: rve; pfam00665 452637012974 Integrase core domain; Region: rve_3; cl15866 452637012975 D-mannonate oxidoreductase; Provisional; Region: PRK08277 452637012976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452637012977 NAD(P) binding site [chemical binding]; other site 452637012978 active site 452637012979 Glucuronate isomerase; Region: UxaC; pfam02614 452637012980 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 452637012981 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 452637012982 catalytic nucleophile [active] 452637012983 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 452637012984 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 452637012985 Protein of unknown function, DUF488; Region: DUF488; cl01246 452637012986 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 452637012987 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 452637012988 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 452637012989 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 452637012990 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 452637012991 nucleotide binding site [chemical binding]; other site 452637012992 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 452637012993 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 452637012994 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 452637012995 active site 452637012996 DNA binding site [nucleotide binding] 452637012997 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 452637012998 DNA binding site [nucleotide binding] 452637012999 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637013000 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452637013001 DNA binding site [nucleotide binding] 452637013002 domain linker motif; other site 452637013003 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 452637013004 ligand binding site [chemical binding]; other site 452637013005 dimerization interface [polypeptide binding]; other site 452637013006 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637013007 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452637013008 DNA binding site [nucleotide binding] 452637013009 domain linker motif; other site 452637013010 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 452637013011 dimerization interface [polypeptide binding]; other site 452637013012 ligand binding site [chemical binding]; other site 452637013013 Glycosyl hydrolase family 52; Region: Glyco_hydro_52; pfam03512 452637013014 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 452637013015 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 452637013016 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 452637013017 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 452637013018 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 452637013019 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 452637013020 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 452637013021 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 452637013022 active site 452637013023 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 452637013024 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 452637013025 dimer interface [polypeptide binding]; other site 452637013026 PYR/PP interface [polypeptide binding]; other site 452637013027 TPP binding site [chemical binding]; other site 452637013028 substrate binding site [chemical binding]; other site 452637013029 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 452637013030 TPP-binding site; other site 452637013031 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 452637013032 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 452637013033 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 452637013034 acyl-activating enzyme (AAE) consensus motif; other site 452637013035 AMP binding site [chemical binding]; other site 452637013036 active site 452637013037 CoA binding site [chemical binding]; other site 452637013038 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 452637013039 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 452637013040 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 452637013041 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 452637013042 inhibitor binding site; inhibition site 452637013043 active site 452637013044 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 452637013045 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 452637013046 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl17706 452637013047 substrate binding site [chemical binding]; other site 452637013048 catalytic residues [active] 452637013049 TPR repeat; Region: TPR_11; pfam13414 452637013050 TPR repeat; Region: TPR_11; pfam13414 452637013051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637013052 TPR motif; other site 452637013053 binding surface 452637013054 TPR repeat; Region: TPR_11; pfam13414 452637013055 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637013056 binding surface 452637013057 TPR motif; other site 452637013058 TPR repeat; Region: TPR_11; pfam13414 452637013059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637013060 TPR motif; other site 452637013061 TPR repeat; Region: TPR_11; pfam13414 452637013062 binding surface 452637013063 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 452637013064 active site 452637013065 catalytic triad [active] 452637013066 oxyanion hole [active] 452637013067 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637013068 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637013069 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 452637013070 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 452637013071 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 452637013072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 452637013073 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 452637013074 NAD(P) binding site [chemical binding]; other site 452637013075 active site 452637013076 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 452637013077 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 452637013078 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 452637013079 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 452637013080 active site 452637013081 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 452637013082 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 452637013083 substrate binding pocket [chemical binding]; other site 452637013084 dimer interface [polypeptide binding]; other site 452637013085 inhibitor binding site; inhibition site 452637013086 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 452637013087 FAD binding site [chemical binding]; other site 452637013088 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 452637013089 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 452637013090 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 452637013091 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 452637013092 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 452637013093 B12 binding site [chemical binding]; other site 452637013094 cobalt ligand [ion binding]; other site 452637013095 Virulence factor; Region: Virulence_fact; pfam13769 452637013096 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 452637013097 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 452637013098 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 452637013099 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 452637013100 catalytic loop [active] 452637013101 iron binding site [ion binding]; other site 452637013102 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 452637013103 nucleotide binding site [chemical binding]; other site 452637013104 D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312 452637013105 mannonate dehydratase; Region: uxuA; TIGR00695 452637013106 mannonate dehydratase; Region: uxuA; TIGR00695 452637013107 Transcriptional regulators [Transcription]; Region: PurR; COG1609 452637013108 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 452637013109 DNA binding site [nucleotide binding] 452637013110 domain linker motif; other site 452637013111 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 452637013112 dimerization interface [polypeptide binding]; other site 452637013113 ligand binding site [chemical binding]; other site 452637013114 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 452637013115 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 452637013116 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 452637013117 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 452637013118 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 452637013119 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452637013120 ATP binding site [chemical binding]; other site 452637013121 putative Mg++ binding site [ion binding]; other site 452637013122 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452637013123 nucleotide binding region [chemical binding]; other site 452637013124 ATP-binding site [chemical binding]; other site 452637013125 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 452637013126 dimer interface [polypeptide binding]; other site 452637013127 active site 452637013128 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 452637013129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 452637013130 hypothetical protein; Provisional; Region: PRK13663 452637013131 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 452637013132 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 452637013133 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 452637013134 active site 452637013135 catalytic residues [active] 452637013136 DNA binding site [nucleotide binding] 452637013137 Int/Topo IB signature motif; other site 452637013138 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 452637013139 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 452637013140 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 452637013141 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 452637013142 Int/Topo IB signature motif; other site 452637013143 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 452637013144 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 452637013145 active site 452637013146 DNA binding site [nucleotide binding] 452637013147 Int/Topo IB signature motif; other site 452637013148 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 452637013149 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 452637013150 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 452637013151 Int/Topo IB signature motif; other site 452637013152 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 452637013153 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 452637013154 DNA binding residues [nucleotide binding] 452637013155 dimer interface [polypeptide binding]; other site 452637013156 metal binding site [ion binding]; metal-binding site 452637013157 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 452637013158 metal-binding site [ion binding] 452637013159 Predicted ATPase [General function prediction only]; Region: COG5293 452637013160 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 452637013161 Domain of unknown function (DUF932); Region: DUF932; cl12129 452637013162 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637013163 DNA binding residues [nucleotide binding] 452637013164 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637013165 dimerization interface [polypeptide binding]; other site 452637013166 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 452637013167 B12 binding site [chemical binding]; other site 452637013168 Radical SAM superfamily; Region: Radical_SAM; pfam04055 452637013169 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 452637013170 FeS/SAM binding site; other site 452637013171 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 452637013172 zinc binding site [ion binding]; other site 452637013173 putative ligand binding site [chemical binding]; other site 452637013174 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 452637013175 TM-ABC transporter signature motif; other site 452637013176 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 452637013177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 452637013178 Walker A/P-loop; other site 452637013179 ATP binding site [chemical binding]; other site 452637013180 Q-loop/lid; other site 452637013181 ABC transporter signature motif; other site 452637013182 Walker B; other site 452637013183 D-loop; other site 452637013184 H-loop/switch region; other site 452637013185 Response regulator receiver domain; Region: Response_reg; pfam00072 452637013186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637013187 active site 452637013188 phosphorylation site [posttranslational modification] 452637013189 intermolecular recognition site; other site 452637013190 dimerization interface [polypeptide binding]; other site 452637013191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637013192 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 452637013193 Walker A motif; other site 452637013194 ATP binding site [chemical binding]; other site 452637013195 Walker B motif; other site 452637013196 arginine finger; other site 452637013197 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 452637013198 DNA binding residues [nucleotide binding] 452637013199 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 452637013200 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 452637013201 active site 452637013202 catalytic residues [active] 452637013203 DNA binding site [nucleotide binding] 452637013204 Int/Topo IB signature motif; other site 452637013205 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 452637013206 metal-binding site [ion binding] 452637013207 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 452637013208 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 452637013209 DNA binding residues [nucleotide binding] 452637013210 dimer interface [polypeptide binding]; other site 452637013211 metal binding site [ion binding]; metal-binding site 452637013212 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 452637013213 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 452637013214 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 452637013215 Int/Topo IB signature motif; other site 452637013216 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 452637013217 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 452637013218 active site 452637013219 DNA binding site [nucleotide binding] 452637013220 Int/Topo IB signature motif; other site 452637013221 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 452637013222 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 452637013223 Int/Topo IB signature motif; other site 452637013224 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 452637013225 Domain of unknown function (DUF305); Region: DUF305; pfam03713 452637013226 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 452637013227 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 452637013228 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 452637013229 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 452637013230 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 452637013231 dimerization interface [polypeptide binding]; other site 452637013232 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 452637013233 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 452637013234 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 452637013235 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452637013236 motif II; other site 452637013237 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 452637013238 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 452637013239 Multicopper oxidase; Region: Cu-oxidase; pfam00394 452637013240 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 452637013241 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 452637013242 Domain of unknown function (DUF305); Region: DUF305; pfam03713 452637013243 Domain of unknown function (DUF305); Region: DUF305; cl17794 452637013244 Adenosine specific kinase; Region: Adenosine_kin; cl00796 452637013245 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 452637013246 dimer interface [polypeptide binding]; other site 452637013247 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 452637013248 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637013249 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637013250 DNA binding residues [nucleotide binding] 452637013251 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 452637013252 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 452637013253 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 452637013254 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 452637013255 dimer interface [polypeptide binding]; other site 452637013256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637013257 catalytic residue [active] 452637013258 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 452637013259 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 452637013260 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637013261 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 452637013262 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637013263 DNA binding residues [nucleotide binding] 452637013264 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 452637013265 Sensory domain found in PocR; Region: PocR; pfam10114 452637013266 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 452637013267 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 452637013268 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637013269 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 452637013270 30S subunit binding site; other site 452637013271 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 452637013272 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 452637013273 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 452637013274 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 452637013275 glycogen binding site [chemical binding]; other site 452637013276 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 452637013277 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 452637013278 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 452637013279 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 452637013280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637013281 putative active site [active] 452637013282 heme pocket [chemical binding]; other site 452637013283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637013284 ATP binding site [chemical binding]; other site 452637013285 Mg2+ binding site [ion binding]; other site 452637013286 G-X-G motif; other site 452637013287 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 452637013288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637013289 active site 452637013290 phosphorylation site [posttranslational modification] 452637013291 intermolecular recognition site; other site 452637013292 dimerization interface [polypeptide binding]; other site 452637013293 Outer membrane efflux protein; Region: OEP; pfam02321 452637013294 Outer membrane efflux protein; Region: OEP; pfam02321 452637013295 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 452637013296 HlyD family secretion protein; Region: HlyD_3; pfam13437 452637013297 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 452637013298 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 452637013299 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 452637013300 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 452637013301 Outer membrane efflux protein; Region: OEP; pfam02321 452637013302 Outer membrane efflux protein; Region: OEP; pfam02321 452637013303 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 452637013304 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 452637013305 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 452637013306 Nitrogen regulatory protein P-II; Region: P-II; smart00938 452637013307 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 452637013308 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 452637013309 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 452637013310 substrate binding site [chemical binding]; other site 452637013311 hexamer interface [polypeptide binding]; other site 452637013312 metal binding site [ion binding]; metal-binding site 452637013313 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 452637013314 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 452637013315 Soluble P-type ATPase [General function prediction only]; Region: COG4087 452637013316 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 452637013317 dimerization interface [polypeptide binding]; other site 452637013318 putative DNA binding site [nucleotide binding]; other site 452637013319 putative Zn2+ binding site [ion binding]; other site 452637013320 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 452637013321 active site residue [active] 452637013322 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 452637013323 DsrE/DsrF-like family; Region: DrsE; pfam02635 452637013324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 452637013325 S-adenosylmethionine binding site [chemical binding]; other site 452637013326 Domain of unknown function (DUF932); Region: DUF932; cl12129 452637013327 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 452637013328 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 452637013329 TIR domain; Region: TIR_2; pfam13676 452637013330 electron transport complex protein RnfC; Provisional; Region: PRK05035 452637013331 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 452637013332 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 452637013333 Protein of unknown function (DUF998); Region: DUF998; pfam06197 452637013334 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 452637013335 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637013336 phosphorylation site [posttranslational modification] 452637013337 dimer interface [polypeptide binding]; other site 452637013338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637013339 ATP binding site [chemical binding]; other site 452637013340 Mg2+ binding site [ion binding]; other site 452637013341 G-X-G motif; other site 452637013342 Uncharacterized conserved protein [Function unknown]; Region: COG1434 452637013343 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 452637013344 putative active site [active] 452637013345 Response regulator receiver domain; Region: Response_reg; pfam00072 452637013346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637013347 active site 452637013348 phosphorylation site [posttranslational modification] 452637013349 intermolecular recognition site; other site 452637013350 dimerization interface [polypeptide binding]; other site 452637013351 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 452637013352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637013353 active site 452637013354 phosphorylation site [posttranslational modification] 452637013355 dimerization interface [polypeptide binding]; other site 452637013356 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 452637013357 DNA binding site [nucleotide binding] 452637013358 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 452637013359 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 452637013360 homotrimer interaction site [polypeptide binding]; other site 452637013361 putative active site [active] 452637013362 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 452637013363 AAA-like domain; Region: AAA_10; pfam12846 452637013364 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 452637013365 Walker A motif; other site 452637013366 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 452637013367 TrwC relaxase; Region: TrwC; pfam08751 452637013368 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 452637013369 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 452637013370 G1 box; other site 452637013371 GTP/Mg2+ binding site [chemical binding]; other site 452637013372 G2 box; other site 452637013373 Switch I region; other site 452637013374 G3 box; other site 452637013375 Switch II region; other site 452637013376 Family description; Region: UvrD_C_2; pfam13538 452637013377 Domain of unknown function (DUF4133); Region: DUF4133; pfam13571 452637013378 AAA-like domain; Region: AAA_10; pfam12846 452637013379 conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193 452637013380 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 452637013381 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 452637013382 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637013383 Walker A motif; other site 452637013384 ATP binding site [chemical binding]; other site 452637013385 Walker B motif; other site 452637013386 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 452637013387 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 452637013388 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 452637013389 DNA binding residues [nucleotide binding] 452637013390 dimerization interface [polypeptide binding]; other site 452637013391 Helix-turn-helix domain; Region: HTH_17; pfam12728 452637013392 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 452637013393 rRNA interaction site [nucleotide binding]; other site 452637013394 S8 interaction site; other site 452637013395 elongation factor Ts; Reviewed; Region: tsf; PRK12332 452637013396 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 452637013397 Elongation factor TS; Region: EF_TS; pfam00889 452637013398 Protein of unknown function (DUF983); Region: DUF983; cl02211 452637013399 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 452637013400 dimer interface [polypeptide binding]; other site 452637013401 putative CheW interface [polypeptide binding]; other site 452637013402 PBP superfamily domain; Region: PBP_like_2; cl17296 452637013403 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 452637013404 Isochorismatase family; Region: Isochorismatase; pfam00857 452637013405 catalytic triad [active] 452637013406 metal binding site [ion binding]; metal-binding site 452637013407 conserved cis-peptide bond; other site 452637013408 HupF/HypC family; Region: HupF_HypC; pfam01455 452637013409 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 452637013410 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 452637013411 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 452637013412 dimerization interface [polypeptide binding]; other site 452637013413 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 452637013414 ATP binding site [chemical binding]; other site 452637013415 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 452637013416 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 452637013417 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 452637013418 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 452637013419 Acylphosphatase; Region: Acylphosphatase; pfam00708 452637013420 HypF finger; Region: zf-HYPF; pfam07503 452637013421 HypF finger; Region: zf-HYPF; pfam07503 452637013422 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 452637013423 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 452637013424 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 452637013425 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637013426 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637013427 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 452637013428 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 452637013429 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 452637013430 NADH(P)-binding; Region: NAD_binding_10; pfam13460 452637013431 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 452637013432 putative NAD(P) binding site [chemical binding]; other site 452637013433 active site 452637013434 Cupin; Region: Cupin_6; pfam12852 452637013435 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637013436 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 452637013437 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 452637013438 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 452637013439 active site 452637013440 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 452637013441 MFS/sugar transport protein; Region: MFS_2; pfam13347 452637013442 Trehalose utilisation; Region: ThuA; pfam06283 452637013443 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 452637013444 ATP binding site [chemical binding]; other site 452637013445 putative Mg++ binding site [ion binding]; other site 452637013446 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 452637013447 nucleotide binding region [chemical binding]; other site 452637013448 ATP-binding site [chemical binding]; other site 452637013449 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137 452637013450 SET domain; Region: SET; pfam00856 452637013451 PspC domain; Region: PspC; pfam04024 452637013452 Predicted transcriptional regulators [Transcription]; Region: COG1695 452637013453 Transcriptional regulator PadR-like family; Region: PadR; cl17335 452637013454 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 452637013455 Domain of unknown function (DUF362); Region: DUF362; pfam04015 452637013456 Uncharacterized conserved protein [Function unknown]; Region: COG2006 452637013457 Response regulator receiver domain; Region: Response_reg; pfam00072 452637013458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637013459 active site 452637013460 phosphorylation site [posttranslational modification] 452637013461 intermolecular recognition site; other site 452637013462 dimerization interface [polypeptide binding]; other site 452637013463 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 452637013464 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 452637013465 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452637013466 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 452637013467 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 452637013468 ATP-grasp domain; Region: ATP-grasp_4; cl17255 452637013469 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 452637013470 IMP binding site; other site 452637013471 dimer interface [polypeptide binding]; other site 452637013472 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 452637013473 Ca binding site [ion binding]; other site 452637013474 Ca binding site (active) [ion binding]; other site 452637013475 ligand binding site [chemical binding]; other site 452637013476 SnoaL-like domain; Region: SnoaL_2; pfam12680 452637013477 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 452637013478 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 452637013479 substrate binding pocket [chemical binding]; other site 452637013480 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 452637013481 Trehalose utilisation; Region: ThuA; pfam06283 452637013482 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 452637013483 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 452637013484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 452637013485 Putative glucoamylase; Region: Glycoamylase; pfam10091 452637013486 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 452637013487 nucleoside/Zn binding site; other site 452637013488 dimer interface [polypeptide binding]; other site 452637013489 catalytic motif [active] 452637013490 Clp protease; Region: CLP_protease; pfam00574 452637013491 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 452637013492 oligomer interface [polypeptide binding]; other site 452637013493 active site residues [active] 452637013494 TIGR03790 family protein; Region: TIGR03790 452637013495 camphor resistance protein CrcB; Provisional; Region: PRK14206 452637013496 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 452637013497 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 452637013498 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 452637013499 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 452637013500 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 452637013501 active site 452637013502 metal binding site [ion binding]; metal-binding site 452637013503 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 452637013504 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 452637013505 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 452637013506 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 452637013507 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 452637013508 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 452637013509 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 452637013510 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 452637013511 putative trimer interface [polypeptide binding]; other site 452637013512 putative CoA binding site [chemical binding]; other site 452637013513 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 452637013514 active site 452637013515 dimer interface [polypeptide binding]; other site 452637013516 metal binding site [ion binding]; metal-binding site 452637013517 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 452637013518 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 452637013519 N-terminal plug; other site 452637013520 ligand-binding site [chemical binding]; other site 452637013521 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 452637013522 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 452637013523 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 452637013524 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 452637013525 dimerization interface [polypeptide binding]; other site 452637013526 DPS ferroxidase diiron center [ion binding]; other site 452637013527 ion pore; other site 452637013528 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 452637013529 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 452637013530 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 452637013531 CHASE2 domain; Region: CHASE2; pfam05226 452637013532 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 452637013533 cyclase homology domain; Region: CHD; cd07302 452637013534 nucleotidyl binding site; other site 452637013535 metal binding site [ion binding]; metal-binding site 452637013536 dimer interface [polypeptide binding]; other site 452637013537 FecR protein; Region: FecR; pfam04773 452637013538 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 452637013539 O-Antigen ligase; Region: Wzy_C; pfam04932 452637013540 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 452637013541 TPR motif; other site 452637013542 binding surface 452637013543 glutamine synthetase; Region: PLN02284 452637013544 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 452637013545 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 452637013546 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 452637013547 active site 452637013548 ATP binding site [chemical binding]; other site 452637013549 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 452637013550 Protein phosphatase 2C; Region: PP2C; pfam00481 452637013551 active site 452637013552 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 452637013553 putative active site pocket [active] 452637013554 dimerization interface [polypeptide binding]; other site 452637013555 putative catalytic residue [active] 452637013556 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 452637013557 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637013558 Walker A motif; other site 452637013559 ATP binding site [chemical binding]; other site 452637013560 Walker B motif; other site 452637013561 arginine finger; other site 452637013562 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 452637013563 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 452637013564 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 452637013565 TrkA-C domain; Region: TrkA_C; pfam02080 452637013566 TrkA-C domain; Region: TrkA_C; pfam02080 452637013567 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 452637013568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 452637013569 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 452637013570 putative substrate translocation pore; other site 452637013571 Polymerase and Histidinol Phosphatase domain of Chlorobi like; Region: PHP_HisPPase_Chlorobi_like; cd12112 452637013572 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 452637013573 active site 452637013574 dimer interface [polypeptide binding]; other site 452637013575 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 452637013576 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 452637013577 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 452637013578 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 452637013579 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 452637013580 ligand binding site [chemical binding]; other site 452637013581 homodimer interface [polypeptide binding]; other site 452637013582 NAD(P) binding site [chemical binding]; other site 452637013583 trimer interface B [polypeptide binding]; other site 452637013584 trimer interface A [polypeptide binding]; other site 452637013585 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 452637013586 dimerization interface [polypeptide binding]; other site 452637013587 ATP binding site [chemical binding]; other site 452637013588 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 452637013589 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 452637013590 active site 452637013591 DNA binding site [nucleotide binding] 452637013592 Int/Topo IB signature motif; other site 452637013593 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 452637013594 rRNA binding site [nucleotide binding]; other site 452637013595 predicted 30S ribosome binding site; other site 452637013596 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 452637013597 nucleoside/Zn binding site; other site 452637013598 dimer interface [polypeptide binding]; other site 452637013599 catalytic motif [active] 452637013600 superoxide dismutase; Provisional; Region: PRK10925 452637013601 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 452637013602 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 452637013603 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 452637013604 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 452637013605 Domain of unknown function DUF59; Region: DUF59; pfam01883 452637013606 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 452637013607 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 452637013608 Walker A motif; other site 452637013609 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 452637013610 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 452637013611 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 452637013612 active site 452637013613 phosphorylation site [posttranslational modification] 452637013614 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 452637013615 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 452637013616 DNA primase; Validated; Region: dnaG; PRK05667 452637013617 CHC2 zinc finger; Region: zf-CHC2; pfam01807 452637013618 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 452637013619 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 452637013620 active site 452637013621 metal binding site [ion binding]; metal-binding site 452637013622 interdomain interaction site; other site 452637013623 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 452637013624 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 452637013625 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 452637013626 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 452637013627 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 452637013628 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 452637013629 DNA binding residues [nucleotide binding] 452637013630 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 452637013631 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 452637013632 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 452637013633 TrkA-C domain; Region: TrkA_C; pfam02080 452637013634 TrkA-C domain; Region: TrkA_C; pfam02080 452637013635 rod shape-determining protein MreB; Provisional; Region: PRK13927 452637013636 MreB and similar proteins; Region: MreB_like; cd10225 452637013637 nucleotide binding site [chemical binding]; other site 452637013638 Mg binding site [ion binding]; other site 452637013639 putative protofilament interaction site [polypeptide binding]; other site 452637013640 RodZ interaction site [polypeptide binding]; other site 452637013641 Transposase IS200 like; Region: Y1_Tnp; cl00848 452637013642 rod shape-determining protein MreC; Provisional; Region: PRK13922 452637013643 rod shape-determining protein MreC; Region: MreC; pfam04085 452637013644 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 452637013645 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 452637013646 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 452637013647 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 452637013648 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 452637013649 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 452637013650 Protein of unknown function DUF58; Region: DUF58; pfam01882 452637013651 MoxR-like ATPases [General function prediction only]; Region: COG0714 452637013652 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637013653 Walker A motif; other site 452637013654 ATP binding site [chemical binding]; other site 452637013655 Walker B motif; other site 452637013656 arginine finger; other site 452637013657 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 452637013658 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 452637013659 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 452637013660 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 452637013661 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 452637013662 Cytochrome c552; Region: Cytochrom_C552; pfam02335 452637013663 OPT oligopeptide transporter protein; Region: OPT; cl14607 452637013664 OPT oligopeptide transporter protein; Region: OPT; cl14607 452637013665 Glycosyl hydrolase family 10; Region: Glyco_10; smart00633 452637013666 Immunoglobulin like; Region: IG_like; smart00410 452637013667 oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728 452637013668 OPT oligopeptide transporter protein; Region: OPT; pfam03169 452637013669 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 452637013670 active site 452637013671 Immunoglobulin C-2 Type; Region: IGc2; smart00408 452637013672 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 452637013673 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 452637013674 active site 452637013675 Zn binding site [ion binding]; other site 452637013676 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 452637013677 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 452637013678 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 452637013679 Immunoglobulin domain; Region: Ig; cd00096 452637013680 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 452637013681 active site 452637013682 catalytic residues [active] 452637013683 NHL repeat; Region: NHL; pfam01436 452637013684 NHL repeat; Region: NHL; pfam01436 452637013685 NHL repeat; Region: NHL; pfam01436 452637013686 NHL repeat; Region: NHL; pfam01436 452637013687 pantoate--beta-alanine ligase; Region: panC; TIGR00018 452637013688 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 452637013689 active site 452637013690 nucleotide binding site [chemical binding]; other site 452637013691 HIGH motif; other site 452637013692 KMSKS motif; other site 452637013693 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 452637013694 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 452637013695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 452637013696 homodimer interface [polypeptide binding]; other site 452637013697 catalytic residue [active] 452637013698 Protein of unknown function (DUF330); Region: DUF330; cl01135 452637013699 mce related protein; Region: MCE; pfam02470 452637013700 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 452637013701 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 452637013702 Walker A/P-loop; other site 452637013703 ATP binding site [chemical binding]; other site 452637013704 Q-loop/lid; other site 452637013705 ABC transporter signature motif; other site 452637013706 Walker B; other site 452637013707 D-loop; other site 452637013708 H-loop/switch region; other site 452637013709 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 452637013710 Permease; Region: Permease; pfam02405 452637013711 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 452637013712 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 452637013713 motif II; other site 452637013714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 452637013715 AAA domain; Region: AAA_22; pfam13401 452637013716 Walker A motif; other site 452637013717 ATP binding site [chemical binding]; other site 452637013718 Walker B motif; other site 452637013719 Family description; Region: UvrD_C_2; pfam13538 452637013720 MASE1; Region: MASE1; cl17823 452637013721 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 452637013722 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 452637013723 putative active site [active] 452637013724 heme pocket [chemical binding]; other site 452637013725 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 452637013726 dimer interface [polypeptide binding]; other site 452637013727 phosphorylation site [posttranslational modification] 452637013728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 452637013729 ATP binding site [chemical binding]; other site 452637013730 Mg2+ binding site [ion binding]; other site 452637013731 G-X-G motif; other site 452637013732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 452637013733 Response regulator receiver domain; Region: Response_reg; pfam00072 452637013734 active site 452637013735 phosphorylation site [posttranslational modification] 452637013736 intermolecular recognition site; other site 452637013737 dimerization interface [polypeptide binding]; other site 452637013738 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 452637013739 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 452637013740 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 452637013741 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 452637013742 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 452637013743 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 452637013744 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 452637013745 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 452637013746 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 452637013747 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 452637013748 RIP metalloprotease RseP; Region: TIGR00054 452637013749 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 452637013750 active site 452637013751 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 452637013752 protein binding site [polypeptide binding]; other site 452637013753 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 452637013754 protein binding site [polypeptide binding]; other site 452637013755 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 452637013756 putative substrate binding region [chemical binding]; other site 452637013757 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 452637013758 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694