-- dump date   	20140619_224757
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
179408000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
179408000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
179408000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408000004	Walker A motif; other site
179408000005	ATP binding site [chemical binding]; other site
179408000006	Walker B motif; other site
179408000007	arginine finger; other site
179408000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
179408000009	DnaA box-binding interface [nucleotide binding]; other site
179408000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
179408000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
179408000012	putative DNA binding surface [nucleotide binding]; other site
179408000013	dimer interface [polypeptide binding]; other site
179408000014	beta-clamp/clamp loader binding surface; other site
179408000015	beta-clamp/translesion DNA polymerase binding surface; other site
179408000016	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
179408000017	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408000018	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408000019	dimer interface [polypeptide binding]; other site
179408000020	phosphorylation site [posttranslational modification]
179408000021	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408000022	ATP binding site [chemical binding]; other site
179408000023	Mg2+ binding site [ion binding]; other site
179408000024	G-X-G motif; other site
179408000025	Predicted permeases [General function prediction only]; Region: COG0701
179408000026	TIGR03943 family protein; Region: TIGR03943
179408000027	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
179408000028	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
179408000029	Bacterial Ig-like domain; Region: Big_5; pfam13205
179408000030	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
179408000031	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
179408000032	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408000033	ATP binding site [chemical binding]; other site
179408000034	Mg2+ binding site [ion binding]; other site
179408000035	G-X-G motif; other site
179408000036	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
179408000037	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408000038	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408000039	ATP binding site [chemical binding]; other site
179408000040	Mg2+ binding site [ion binding]; other site
179408000041	G-X-G motif; other site
179408000042	Homeodomain-like domain; Region: HTH_23; pfam13384
179408000043	Winged helix-turn helix; Region: HTH_29; pfam13551
179408000044	Winged helix-turn helix; Region: HTH_33; pfam13592
179408000045	DDE superfamily endonuclease; Region: DDE_3; pfam13358
179408000046	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
179408000047	Ion channel; Region: Ion_trans_2; pfam07885
179408000048	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
179408000049	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
179408000050	putative metal binding site [ion binding]; other site
179408000051	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408000052	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408000053	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408000054	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408000055	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408000056	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408000057	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408000058	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408000059	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408000060	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408000061	Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664
179408000062	Protein phosphatase 2C; Region: PP2C; pfam00481
179408000063	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
179408000064	active site
179408000065	Curli production assembly/transport component CsgG; Region: CsgG; cl17434
179408000066	Domain of unknown function (DUF1823); Region: DUF1823; pfam08853
179408000067	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
179408000068	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
179408000069	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
179408000070	Nitrogen regulatory protein P-II; Region: P-II; cl00412
179408000071	Domain of unknown function (DUF897); Region: DUF897; pfam05982
179408000072	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
179408000073	catalytic triad [active]
179408000074	dimer interface [polypeptide binding]; other site
179408000075	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
179408000076	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408000077	putative active site [active]
179408000078	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408000079	binding surface
179408000080	Tetratricopeptide repeat; Region: TPR_16; pfam13432
179408000081	TPR motif; other site
179408000082	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408000083	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408000084	binding surface
179408000085	TPR motif; other site
179408000086	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408000087	TPR repeat; Region: TPR_11; pfam13414
179408000088	binding surface
179408000089	TPR motif; other site
179408000090	Tetratricopeptide repeat; Region: TPR_16; pfam13432
179408000091	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
179408000092	Tetratricopeptide repeat; Region: TPR_16; pfam13432
179408000093	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408000094	binding surface
179408000095	TPR motif; other site
179408000096	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
179408000097	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408000098	TPR motif; other site
179408000099	binding surface
179408000100	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408000101	binding surface
179408000102	TPR motif; other site
179408000103	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
179408000104	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408000105	binding surface
179408000106	TPR motif; other site
179408000107	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408000108	binding surface
179408000109	TPR motif; other site
179408000110	Methyltransferase domain; Region: Methyltransf_24; pfam13578
179408000111	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
179408000112	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408000113	binding surface
179408000114	TPR motif; other site
179408000115	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408000116	binding surface
179408000117	TPR motif; other site
179408000118	Protein of unknown function (DUF563); Region: DUF563; pfam04577
179408000119	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408000120	binding surface
179408000121	TPR repeat; Region: TPR_11; pfam13414
179408000122	TPR motif; other site
179408000123	Tetratricopeptide repeat; Region: TPR_16; pfam13432
179408000124	TPR repeat; Region: TPR_11; pfam13414
179408000125	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408000126	binding surface
179408000127	TPR motif; other site
179408000128	TPR repeat; Region: TPR_11; pfam13414
179408000129	TPR repeat; Region: TPR_11; pfam13414
179408000130	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408000131	binding surface
179408000132	TPR motif; other site
179408000133	TPR repeat; Region: TPR_11; pfam13414
179408000134	TPR repeat; Region: TPR_11; pfam13414
179408000135	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408000136	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408000137	binding surface
179408000138	TPR motif; other site
179408000139	TPR repeat; Region: TPR_11; pfam13414
179408000140	Protein of unknown function (DUF563); Region: DUF563; pfam04577
179408000141	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408000142	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408000143	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408000144	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408000145	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408000146	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408000147	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408000148	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408000149	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
179408000150	active site
179408000151	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
179408000152	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
179408000153	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
179408000154	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
179408000155	Predicted membrane protein [Function unknown]; Region: COG3463
179408000156	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
179408000157	Predicted membrane protein [Function unknown]; Region: COG3463
179408000158	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
179408000159	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
179408000160	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
179408000161	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
179408000162	ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165
179408000163	Domain of unknown function (DUF309); Region: DUF309; pfam03745
179408000164	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
179408000165	OstA-like protein; Region: OstA; pfam03968
179408000166	OstA-like protein; Region: OstA; cl00844
179408000167	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
179408000168	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
179408000169	Walker A/P-loop; other site
179408000170	ATP binding site [chemical binding]; other site
179408000171	Q-loop/lid; other site
179408000172	ABC transporter signature motif; other site
179408000173	Walker B; other site
179408000174	D-loop; other site
179408000175	H-loop/switch region; other site
179408000176	Predicted permeases [General function prediction only]; Region: COG0795
179408000177	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
179408000178	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
179408000179	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
179408000180	putative active site [active]
179408000181	Double zinc ribbon; Region: DZR; pfam12773
179408000182	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
179408000183	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
179408000184	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
179408000185	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
179408000186	phosphopeptide binding site; other site
179408000187	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
179408000188	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
179408000189	phosphopeptide binding site; other site
179408000190	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
179408000191	PRC-barrel domain; Region: PRC; pfam05239
179408000192	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
179408000193	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
179408000194	phosphopeptide binding site; other site
179408000195	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
179408000196	prephenate dehydratase; Provisional; Region: PRK11898
179408000197	Prephenate dehydratase; Region: PDT; pfam00800
179408000198	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
179408000199	putative L-Phe binding site [chemical binding]; other site
179408000200	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408000201	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408000202	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408000203	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408000204	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408000205	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408000206	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408000207	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
179408000208	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
179408000209	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
179408000210	elongation factor Tu; Region: tufA; CHL00071
179408000211	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
179408000212	G1 box; other site
179408000213	GEF interaction site [polypeptide binding]; other site
179408000214	GTP/Mg2+ binding site [chemical binding]; other site
179408000215	Switch I region; other site
179408000216	G2 box; other site
179408000217	G3 box; other site
179408000218	Switch II region; other site
179408000219	G4 box; other site
179408000220	G5 box; other site
179408000221	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
179408000222	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
179408000223	Antibiotic Binding Site [chemical binding]; other site
179408000224	elongation factor G; Reviewed; Region: PRK00007
179408000225	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
179408000226	G1 box; other site
179408000227	putative GEF interaction site [polypeptide binding]; other site
179408000228	GTP/Mg2+ binding site [chemical binding]; other site
179408000229	Switch I region; other site
179408000230	G2 box; other site
179408000231	G3 box; other site
179408000232	Switch II region; other site
179408000233	G4 box; other site
179408000234	G5 box; other site
179408000235	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
179408000236	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
179408000237	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
179408000238	30S ribosomal protein S7; Validated; Region: PRK05302
179408000239	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
179408000240	S17 interaction site [polypeptide binding]; other site
179408000241	S8 interaction site; other site
179408000242	16S rRNA interaction site [nucleotide binding]; other site
179408000243	streptomycin interaction site [chemical binding]; other site
179408000244	23S rRNA interaction site [nucleotide binding]; other site
179408000245	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
179408000246	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
179408000247	metal binding site 2 [ion binding]; metal-binding site
179408000248	putative DNA binding helix; other site
179408000249	metal binding site 1 [ion binding]; metal-binding site
179408000250	dimer interface [polypeptide binding]; other site
179408000251	structural Zn2+ binding site [ion binding]; other site
179408000252	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
179408000253	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408000254	active site
179408000255	phosphorylation site [posttranslational modification]
179408000256	intermolecular recognition site; other site
179408000257	dimerization interface [polypeptide binding]; other site
179408000258	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
179408000259	DNA binding site [nucleotide binding]
179408000260	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
179408000261	Ferritin-like domain; Region: Ferritin; pfam00210
179408000262	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
179408000263	dinuclear metal binding motif [ion binding]; other site
179408000264	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397
179408000265	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
179408000266	PDGLE domain; Region: PDGLE; pfam13190
179408000267	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
179408000268	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
179408000269	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
179408000270	Walker A/P-loop; other site
179408000271	ATP binding site [chemical binding]; other site
179408000272	Q-loop/lid; other site
179408000273	ABC transporter signature motif; other site
179408000274	Walker B; other site
179408000275	D-loop; other site
179408000276	H-loop/switch region; other site
179408000277	Ion transport protein; Region: Ion_trans; pfam00520
179408000278	Ion channel; Region: Ion_trans_2; pfam07885
179408000279	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
179408000280	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
179408000281	putative ligand binding site [chemical binding]; other site
179408000282	putative NAD binding site [chemical binding]; other site
179408000283	catalytic site [active]
179408000284	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
179408000285	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
179408000286	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
179408000287	hinge; other site
179408000288	active site
179408000289	Mitochondrial ATP synthase g subunit; Region: ATP-synt_G; pfam04718
179408000290	Uncharacterized conserved protein [Function unknown]; Region: COG1359
179408000291	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
179408000292	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
179408000293	MOSC domain; Region: MOSC; pfam03473
179408000294	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408000295	Probable transposase; Region: OrfB_IS605; pfam01385
179408000296	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408000297	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
179408000298	Methyltransferase domain; Region: Methyltransf_31; pfam13847
179408000299	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408000300	S-adenosylmethionine binding site [chemical binding]; other site
179408000301	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408000302	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
179408000303	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
179408000304	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408000305	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
179408000306	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
179408000307	active site
179408000308	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
179408000309	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
179408000310	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
179408000311	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
179408000312	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
179408000313	ligand binding site [chemical binding]; other site
179408000314	flexible hinge region; other site
179408000315	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
179408000316	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
179408000317	putative active site [active]
179408000318	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
179408000319	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408000320	Walker A/P-loop; other site
179408000321	ATP binding site [chemical binding]; other site
179408000322	Q-loop/lid; other site
179408000323	ABC transporter signature motif; other site
179408000324	Walker B; other site
179408000325	D-loop; other site
179408000326	H-loop/switch region; other site
179408000327	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
179408000328	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
179408000329	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
179408000330	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
179408000331	Ligand binding site; other site
179408000332	Putative Catalytic site; other site
179408000333	DXD motif; other site
179408000334	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
179408000335	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
179408000336	NAD(P) binding site [chemical binding]; other site
179408000337	active site
179408000338	Methyltransferase domain; Region: Methyltransf_23; pfam13489
179408000339	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408000340	S-adenosylmethionine binding site [chemical binding]; other site
179408000341	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
179408000342	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
179408000343	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
179408000344	NADP binding site [chemical binding]; other site
179408000345	active site
179408000346	putative substrate binding site [chemical binding]; other site
179408000347	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
179408000348	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
179408000349	Ligand binding site; other site
179408000350	Putative Catalytic site; other site
179408000351	DXD motif; other site
179408000352	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
179408000353	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
179408000354	oxyanion hole [active]
179408000355	PRC-barrel domain; Region: PRC; pfam05239
179408000356	PRC-barrel domain; Region: PRC; pfam05239
179408000357	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
179408000358	Walker A/P-loop; other site
179408000359	ATP binding site [chemical binding]; other site
179408000360	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
179408000361	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
179408000362	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
179408000363	ABC transporter signature motif; other site
179408000364	Walker B; other site
179408000365	D-loop; other site
179408000366	H-loop/switch region; other site
179408000367	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408000368	Probable transposase; Region: OrfB_IS605; pfam01385
179408000369	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408000370	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
179408000371	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
179408000372	hinge; other site
179408000373	active site
179408000374	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
179408000375	Domain of unknown function (DUF4394); Region: DUF4394; pfam14339
179408000376	PQQ-like domain; Region: PQQ_2; pfam13360
179408000377	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408000378	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
179408000379	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408000380	putative active site [active]
179408000381	putative NTP binding site [chemical binding]; other site
179408000382	putative nucleic acid binding site [nucleotide binding]; other site
179408000383	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408000384	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408000385	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408000386	active site
179408000387	Mer2; Region: Mer2; pfam09074
179408000388	acetolactate synthase; Reviewed; Region: PRK08322
179408000389	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
179408000390	PYR/PP interface [polypeptide binding]; other site
179408000391	dimer interface [polypeptide binding]; other site
179408000392	TPP binding site [chemical binding]; other site
179408000393	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
179408000394	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
179408000395	TPP-binding site [chemical binding]; other site
179408000396	dimer interface [polypeptide binding]; other site
179408000397	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
179408000398	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
179408000399	NAD(P) binding site [chemical binding]; other site
179408000400	catalytic residues [active]
179408000401	TPR repeat; Region: TPR_11; pfam13414
179408000402	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
179408000403	TPR motif; other site
179408000404	binding surface
179408000405	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
179408000406	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
179408000407	putative ligand binding site [chemical binding]; other site
179408000408	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
179408000409	Chain length determinant protein; Region: Wzz; cl15801
179408000410	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
179408000411	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
179408000412	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
179408000413	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
179408000414	SLBB domain; Region: SLBB; pfam10531
179408000415	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
179408000416	ligand-binding site [chemical binding]; other site
179408000417	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
179408000418	heterocyst differentiation control protein; Reviewed; Region: hetR; PRK13245
179408000419	Integral membrane protein DUF92; Region: DUF92; pfam01940
179408000420	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408000421	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408000422	Probable transposase; Region: OrfB_IS605; pfam01385
179408000423	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408000424	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
179408000425	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
179408000426	active site
179408000427	metal binding site [ion binding]; metal-binding site
179408000428	Lipase (class 2); Region: Lipase_2; pfam01674
179408000429	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
179408000430	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
179408000431	Lipase (class 2); Region: Lipase_2; pfam01674
179408000432	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
179408000433	YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831
179408000434	toxin interface [polypeptide binding]; other site
179408000435	Zn binding site [ion binding]; other site
179408000436	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
179408000437	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
179408000438	RNA methyltransferase, RsmE family; Region: TIGR00046
179408000439	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
179408000440	ferredoxin-sulfite reductase; Region: sir; TIGR02042
179408000441	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
179408000442	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
179408000443	Protein of unknown function (DUF3571); Region: DUF3571; pfam12095
179408000444	Protein of unknown function (DUF2614); Region: DUF2614; cl07936
179408000445	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
179408000446	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408000447	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
179408000448	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
179408000449	putative ligand binding site [chemical binding]; other site
179408000450	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
179408000451	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
179408000452	Walker A/P-loop; other site
179408000453	ATP binding site [chemical binding]; other site
179408000454	Q-loop/lid; other site
179408000455	ABC transporter signature motif; other site
179408000456	Walker B; other site
179408000457	D-loop; other site
179408000458	H-loop/switch region; other site
179408000459	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
179408000460	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
179408000461	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
179408000462	TM-ABC transporter signature motif; other site
179408000463	seryl-tRNA synthetase; Provisional; Region: PRK05431
179408000464	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
179408000465	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
179408000466	dimer interface [polypeptide binding]; other site
179408000467	active site
179408000468	motif 1; other site
179408000469	motif 2; other site
179408000470	motif 3; other site
179408000471	methionine sulfoxide reductase A; Provisional; Region: PRK00058
179408000472	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
179408000473	Dynamin family; Region: Dynamin_N; pfam00350
179408000474	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
179408000475	G1 box; other site
179408000476	GTP/Mg2+ binding site [chemical binding]; other site
179408000477	G2 box; other site
179408000478	Switch I region; other site
179408000479	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
179408000480	G3 box; other site
179408000481	Switch II region; other site
179408000482	GTP/Mg2+ binding site [chemical binding]; other site
179408000483	G4 box; other site
179408000484	G5 box; other site
179408000485	Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722
179408000486	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
179408000487	putative active site [active]
179408000488	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
179408000489	feedback inhibition sensing region; other site
179408000490	homohexameric interface [polypeptide binding]; other site
179408000491	nucleotide binding site [chemical binding]; other site
179408000492	N-acetyl-L-glutamate binding site [chemical binding]; other site
179408000493	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
179408000494	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
179408000495	motif II; other site
179408000496	rod shape-determining protein MreD; Region: MreD; cl01087
179408000497	rod shape-determining protein MreC; Provisional; Region: PRK13922
179408000498	rod shape-determining protein MreC; Region: MreC; pfam04085
179408000499	rod shape-determining protein MreB; Provisional; Region: PRK13927
179408000500	MreB and similar proteins; Region: MreB_like; cd10225
179408000501	nucleotide binding site [chemical binding]; other site
179408000502	Mg binding site [ion binding]; other site
179408000503	putative protofilament interaction site [polypeptide binding]; other site
179408000504	RodZ interaction site [polypeptide binding]; other site
179408000505	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
179408000506	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
179408000507	dimer interface [polypeptide binding]; other site
179408000508	ssDNA binding site [nucleotide binding]; other site
179408000509	tetramer (dimer of dimers) interface [polypeptide binding]; other site
179408000510	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
179408000511	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
179408000512	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
179408000513	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
179408000514	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
179408000515	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
179408000516	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
179408000517	active site
179408000518	Substrate binding site; other site
179408000519	Mg++ binding site; other site
179408000520	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
179408000521	putative trimer interface [polypeptide binding]; other site
179408000522	putative CoA binding site [chemical binding]; other site
179408000523	arginine decarboxylase; Provisional; Region: PRK05354
179408000524	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
179408000525	dimer interface [polypeptide binding]; other site
179408000526	active site
179408000527	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
179408000528	catalytic residues [active]
179408000529	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
179408000530	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
179408000531	Helix-turn-helix domain; Region: HTH_25; pfam13413
179408000532	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
179408000533	light-harvesting-like protein 3; Provisional; Region: PLN00014
179408000534	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
179408000535	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
179408000536	DNA binding residues [nucleotide binding]
179408000537	dimer interface [polypeptide binding]; other site
179408000538	metal binding site [ion binding]; metal-binding site
179408000539	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
179408000540	YcfA-like protein; Region: YcfA; cl00752
179408000541	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
179408000542	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
179408000543	nucleotide binding site [chemical binding]; other site
179408000544	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
179408000545	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
179408000546	ATP binding site [chemical binding]; other site
179408000547	putative Mg++ binding site [ion binding]; other site
179408000548	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
179408000549	nucleotide binding region [chemical binding]; other site
179408000550	ATP-binding site [chemical binding]; other site
179408000551	AAA ATPase domain; Region: AAA_16; pfam13191
179408000552	NACHT domain; Region: NACHT; pfam05729
179408000553	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
179408000554	putative catalytic site [active]
179408000555	putative phosphate binding site [ion binding]; other site
179408000556	active site
179408000557	metal binding site A [ion binding]; metal-binding site
179408000558	DNA binding site [nucleotide binding]
179408000559	putative AP binding site [nucleotide binding]; other site
179408000560	putative metal binding site B [ion binding]; other site
179408000561	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
179408000562	Ycf39; Provisional; Region: ycf39; CHL00194
179408000563	NAD(P) binding site [chemical binding]; other site
179408000564	putative active site [active]
179408000565	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
179408000566	lipoyl synthase; Provisional; Region: PRK05481
179408000567	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408000568	FeS/SAM binding site; other site
179408000569	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
179408000570	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
179408000571	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
179408000572	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
179408000573	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
179408000574	DNA binding residues [nucleotide binding]
179408000575	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
179408000576	metal binding site 2 [ion binding]; metal-binding site
179408000577	putative DNA binding helix; other site
179408000578	metal binding site 1 [ion binding]; metal-binding site
179408000579	dimer interface [polypeptide binding]; other site
179408000580	structural Zn2+ binding site [ion binding]; other site
179408000581	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
179408000582	active site
179408000583	catalytic triad [active]
179408000584	oxyanion hole [active]
179408000585	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
179408000586	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
179408000587	active site
179408000588	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408000589	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
179408000590	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
179408000591	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
179408000592	acyl-activating enzyme (AAE) consensus motif; other site
179408000593	AMP binding site [chemical binding]; other site
179408000594	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
179408000595	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
179408000596	N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319
179408000597	Ycf46; Provisional; Region: ycf46; CHL00195
179408000598	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408000599	Walker A motif; other site
179408000600	ATP binding site [chemical binding]; other site
179408000601	Walker B motif; other site
179408000602	arginine finger; other site
179408000603	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
179408000604	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
179408000605	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
179408000606	G-X-X-G motif; other site
179408000607	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
179408000608	RxxxH motif; other site
179408000609	putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654
179408000610	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
179408000611	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
179408000612	Bacterial PH domain; Region: DUF304; pfam03703
179408000613	ribonuclease P; Reviewed; Region: rnpA; PRK03031
179408000614	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
179408000615	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
179408000616	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
179408000617	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
179408000618	HlyD family secretion protein; Region: HlyD_3; pfam13437
179408000619	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
179408000620	MarR family; Region: MarR_2; cl17246
179408000621	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408000622	Protein of unknown function (DUF433); Region: DUF433; pfam04255
179408000623	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
179408000624	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
179408000625	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
179408000626	substrate binding site; other site
179408000627	metal-binding site
179408000628	Oligomer interface; other site
179408000629	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
179408000630	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
179408000631	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
179408000632	Probable Catalytic site; other site
179408000633	metal-binding site
179408000634	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
179408000635	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408000636	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408000637	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
179408000638	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
179408000639	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408000640	Cytochrome B6-F complex subunit 5; Region: PetG; pfam02529
179408000641	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
179408000642	Cytochrome c; Region: Cytochrom_C; pfam00034
179408000643	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
179408000644	Cna protein B-type domain; Region: Cna_B; pfam05738
179408000645	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
179408000646	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408000647	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
179408000648	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
179408000649	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408000650	dimer interface [polypeptide binding]; other site
179408000651	conserved gate region; other site
179408000652	putative PBP binding loops; other site
179408000653	ABC-ATPase subunit interface; other site
179408000654	sulfate transport protein; Provisional; Region: cysT; CHL00187
179408000655	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408000656	dimer interface [polypeptide binding]; other site
179408000657	conserved gate region; other site
179408000658	putative PBP binding loops; other site
179408000659	ABC-ATPase subunit interface; other site
179408000660	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
179408000661	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
179408000662	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408000663	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408000664	structural tetrad; other site
179408000665	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
179408000666	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
179408000667	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
179408000668	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
179408000669	active site
179408000670	aspartate aminotransferase; Provisional; Region: PRK05957
179408000671	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
179408000672	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408000673	homodimer interface [polypeptide binding]; other site
179408000674	catalytic residue [active]
179408000675	XisI protein; Region: XisI; pfam08869
179408000676	XisH protein; Region: XisH; pfam08814
179408000677	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
179408000678	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
179408000679	Walker A/P-loop; other site
179408000680	ATP binding site [chemical binding]; other site
179408000681	Q-loop/lid; other site
179408000682	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
179408000683	ABC transporter signature motif; other site
179408000684	Walker B; other site
179408000685	D-loop; other site
179408000686	H-loop/switch region; other site
179408000687	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
179408000688	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
179408000689	active site
179408000690	metal binding site [ion binding]; metal-binding site
179408000691	DNA binding site [nucleotide binding]
179408000692	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
179408000693	Protein of unknown function (DUF433); Region: DUF433; pfam04255
179408000694	Inward rectifier potassium channel; Region: IRK; pfam01007
179408000695	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
179408000696	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
179408000697	NAD(P) binding site [chemical binding]; other site
179408000698	active site
179408000699	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
179408000700	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
179408000701	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408000702	S-adenosylmethionine binding site [chemical binding]; other site
179408000703	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408000704	TPR repeat; Region: TPR_11; pfam13414
179408000705	binding surface
179408000706	TPR motif; other site
179408000707	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408000708	binding surface
179408000709	TPR motif; other site
179408000710	TPR repeat; Region: TPR_11; pfam13414
179408000711	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408000712	binding surface
179408000713	TPR motif; other site
179408000714	TPR repeat; Region: TPR_11; pfam13414
179408000715	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408000716	binding surface
179408000717	TPR motif; other site
179408000718	TPR repeat; Region: TPR_11; pfam13414
179408000719	Uncharacterized conserved protein [Function unknown]; Region: COG0393
179408000720	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
179408000721	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
179408000722	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
179408000723	substrate binding pocket [chemical binding]; other site
179408000724	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
179408000725	B12 binding site [chemical binding]; other site
179408000726	cobalt ligand [ion binding]; other site
179408000727	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
179408000728	Protein of unknown function, DUF488; Region: DUF488; pfam04343
179408000729	Protein of unknown function (DUF3082); Region: DUF3082; pfam11282
179408000730	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534
179408000731	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
179408000732	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
179408000733	dimer interface [polypeptide binding]; other site
179408000734	phosphorylation site [posttranslational modification]
179408000735	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408000736	ATP binding site [chemical binding]; other site
179408000737	Mg2+ binding site [ion binding]; other site
179408000738	G-X-G motif; other site
179408000739	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
179408000740	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408000741	S-adenosylmethionine binding site [chemical binding]; other site
179408000742	galactokinase; Provisional; Region: PRK05101
179408000743	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
179408000744	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
179408000745	Cupin domain; Region: Cupin_2; cl17218
179408000746	Predicted integral membrane protein [Function unknown]; Region: COG5637
179408000747	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
179408000748	putative hydrophobic ligand binding site [chemical binding]; other site
179408000749	Methyltransferase domain; Region: Methyltransf_23; pfam13489
179408000750	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408000751	S-adenosylmethionine binding site [chemical binding]; other site
179408000752	Isochorismatase family; Region: Isochorismatase; pfam00857
179408000753	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
179408000754	catalytic triad [active]
179408000755	dimer interface [polypeptide binding]; other site
179408000756	conserved cis-peptide bond; other site
179408000757	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
179408000758	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
179408000759	UbiA prenyltransferase family; Region: UbiA; pfam01040
179408000760	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
179408000761	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
179408000762	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
179408000763	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
179408000764	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
179408000765	putative ligand binding site [chemical binding]; other site
179408000766	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
179408000767	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408000768	DXD motif; other site
179408000769	Cellulose synthase-like protein; Region: PLN02893
179408000770	CHAT domain; Region: CHAT; cl17868
179408000771	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
179408000772	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
179408000773	phosphopeptide binding site; other site
179408000774	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
179408000775	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
179408000776	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
179408000777	glutathione synthetase; Provisional; Region: PRK05246
179408000778	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
179408000779	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
179408000780	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
179408000781	GSH binding site [chemical binding]; other site
179408000782	catalytic residues [active]
179408000783	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
179408000784	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
179408000785	HflX GTPase family; Region: HflX; cd01878
179408000786	G1 box; other site
179408000787	GTP/Mg2+ binding site [chemical binding]; other site
179408000788	Switch I region; other site
179408000789	G2 box; other site
179408000790	G3 box; other site
179408000791	Switch II region; other site
179408000792	G4 box; other site
179408000793	G5 box; other site
179408000794	light-harvesting-like protein 3; Provisional; Region: PLN00014
179408000795	Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425
179408000796	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
179408000797	CAAX protease self-immunity; Region: Abi; pfam02517
179408000798	Protein of unknown function (DUF433); Region: DUF433; pfam04255
179408000799	Uncharacterized conserved protein [Function unknown]; Region: COG2442
179408000800	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408000801	putative active site [active]
179408000802	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
179408000803	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
179408000804	active site
179408000805	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
179408000806	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
179408000807	active site
179408000808	catalytic residues [active]
179408000809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
179408000810	KWG Leptospira; Region: KWG; pfam07656
179408000811	KWG Leptospira; Region: KWG; pfam07656
179408000812	KWG Leptospira; Region: KWG; pfam07656
179408000813	KWG Leptospira; Region: KWG; pfam07656
179408000814	Subtilase family; Region: Peptidase_S8; pfam00082
179408000815	catalytic residues [active]
179408000816	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408000817	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408000818	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408000819	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408000820	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408000821	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
179408000822	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408000823	Leucine-rich repeats; other site
179408000824	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408000825	Substrate binding site [chemical binding]; other site
179408000826	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408000827	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408000828	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
179408000829	Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311
179408000830	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
179408000831	HPP family; Region: HPP; pfam04982
179408000832	Dihaem cytochrome c; Region: DHC; pfam09626
179408000833	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
179408000834	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
179408000835	dimer interface [polypeptide binding]; other site
179408000836	substrate binding site [chemical binding]; other site
179408000837	metal binding sites [ion binding]; metal-binding site
179408000838	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408000839	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408000840	active site
179408000841	ATP binding site [chemical binding]; other site
179408000842	substrate binding site [chemical binding]; other site
179408000843	activation loop (A-loop); other site
179408000844	Protein kinase domain; Region: Pkinase; pfam00069
179408000845	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408000846	active site
179408000847	ATP binding site [chemical binding]; other site
179408000848	substrate binding site [chemical binding]; other site
179408000849	activation loop (A-loop); other site
179408000850	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408000851	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408000852	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408000853	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408000854	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408000855	PAS domain; Region: PAS_9; pfam13426
179408000856	putative active site [active]
179408000857	heme pocket [chemical binding]; other site
179408000858	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
179408000859	cyclase homology domain; Region: CHD; cd07302
179408000860	nucleotidyl binding site; other site
179408000861	metal binding site [ion binding]; metal-binding site
179408000862	dimer interface [polypeptide binding]; other site
179408000863	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
179408000864	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
179408000865	Walker A/P-loop; other site
179408000866	ATP binding site [chemical binding]; other site
179408000867	Q-loop/lid; other site
179408000868	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
179408000869	ABC transporter signature motif; other site
179408000870	Walker B; other site
179408000871	D-loop; other site
179408000872	H-loop/switch region; other site
179408000873	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408000874	putative active site [active]
179408000875	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
179408000876	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408000877	Walker A motif; other site
179408000878	ATP binding site [chemical binding]; other site
179408000879	Walker B motif; other site
179408000880	arginine finger; other site
179408000881	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
179408000882	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
179408000883	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
179408000884	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
179408000885	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
179408000886	Walker A/P-loop; other site
179408000887	ATP binding site [chemical binding]; other site
179408000888	Q-loop/lid; other site
179408000889	ABC transporter signature motif; other site
179408000890	Walker B; other site
179408000891	D-loop; other site
179408000892	H-loop/switch region; other site
179408000893	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
179408000894	putative carbohydrate binding site [chemical binding]; other site
179408000895	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408000896	Methyltransferase domain; Region: Methyltransf_31; pfam13847
179408000897	S-adenosylmethionine binding site [chemical binding]; other site
179408000898	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
179408000899	Tropomyosin like; Region: Tropomyosin_1; pfam12718
179408000900	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408000901	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
179408000902	Probable Catalytic site; other site
179408000903	metal-binding site
179408000904	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408000905	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
179408000906	Probable Catalytic site; other site
179408000907	metal-binding site
179408000908	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408000909	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
179408000910	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
179408000911	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408000912	S-adenosylmethionine binding site [chemical binding]; other site
179408000913	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408000914	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
179408000915	putative ADP-binding pocket [chemical binding]; other site
179408000916	Response regulator receiver domain; Region: Response_reg; pfam00072
179408000917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408000918	active site
179408000919	phosphorylation site [posttranslational modification]
179408000920	intermolecular recognition site; other site
179408000921	dimerization interface [polypeptide binding]; other site
179408000922	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
179408000923	dimer interface [polypeptide binding]; other site
179408000924	phosphorylation site [posttranslational modification]
179408000925	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408000926	ATP binding site [chemical binding]; other site
179408000927	Mg2+ binding site [ion binding]; other site
179408000928	G-X-G motif; other site
179408000929	Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219
179408000930	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408000931	active site
179408000932	ATP binding site [chemical binding]; other site
179408000933	substrate binding site [chemical binding]; other site
179408000934	activation loop (A-loop); other site
179408000935	AAA ATPase domain; Region: AAA_16; pfam13191
179408000936	Predicted ATPase [General function prediction only]; Region: COG3899
179408000937	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408000938	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408000939	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408000940	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408000941	dimer interface [polypeptide binding]; other site
179408000942	phosphorylation site [posttranslational modification]
179408000943	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408000944	ATP binding site [chemical binding]; other site
179408000945	Mg2+ binding site [ion binding]; other site
179408000946	G-X-G motif; other site
179408000947	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408000948	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408000949	active site
179408000950	phosphorylation site [posttranslational modification]
179408000951	intermolecular recognition site; other site
179408000952	dimerization interface [polypeptide binding]; other site
179408000953	Domain of unknown function (DUF1802); Region: DUF1802; pfam08819
179408000954	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408000955	dimer interface [polypeptide binding]; other site
179408000956	conserved gate region; other site
179408000957	ABC-ATPase subunit interface; other site
179408000958	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
179408000959	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
179408000960	Walker A/P-loop; other site
179408000961	ATP binding site [chemical binding]; other site
179408000962	Q-loop/lid; other site
179408000963	ABC transporter signature motif; other site
179408000964	Walker B; other site
179408000965	D-loop; other site
179408000966	H-loop/switch region; other site
179408000967	GTPase Era; Reviewed; Region: era; PRK00089
179408000968	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
179408000969	G1 box; other site
179408000970	GTP/Mg2+ binding site [chemical binding]; other site
179408000971	Switch I region; other site
179408000972	G2 box; other site
179408000973	Switch II region; other site
179408000974	G3 box; other site
179408000975	G4 box; other site
179408000976	G5 box; other site
179408000977	KH domain; Region: KH_2; pfam07650
179408000978	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408000979	putative active site [active]
179408000980	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
179408000981	phosphoenolpyruvate synthase; Validated; Region: PRK06241
179408000982	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
179408000983	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
179408000984	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
179408000985	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
179408000986	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
179408000987	ligand binding site [chemical binding]; other site
179408000988	flexible hinge region; other site
179408000989	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
179408000990	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
179408000991	Alternative oxidase, ferritin-like diiron-binding domain; Region: AOX; cd01053
179408000992	diiron binding motif [ion binding]; other site
179408000993	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
179408000994	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
179408000995	Retropepsins; pepsin-like aspartate proteases; Region: retropepsin_like; cd00303
179408000996	inhibitor binding site; inhibition site
179408000997	catalytic motif [active]
179408000998	Catalytic residue [active]
179408000999	Active site flap [active]
179408001000	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649
179408001001	ATP-NAD kinase; Region: NAD_kinase; pfam01513
179408001002	Ycf39; Provisional; Region: ycf39; CHL00194
179408001003	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
179408001004	NAD(P) binding site [chemical binding]; other site
179408001005	putative active site [active]
179408001006	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
179408001007	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
179408001008	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
179408001009	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
179408001010	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
179408001011	ligand binding site [chemical binding]; other site
179408001012	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
179408001013	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
179408001014	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
179408001015	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4295
179408001016	Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021
179408001017	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
179408001018	PIN domain nuclease, a component of toxin-antitoxin system (PIN domain) [Signal transduction mechanisms]; Region: COG3744
179408001019	putative active site [active]
179408001020	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
179408001021	active site
179408001022	catalytic site [active]
179408001023	substrate binding site [chemical binding]; other site
179408001024	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
179408001025	Transposase [DNA replication, recombination, and repair]; Region: COG5421
179408001026	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
179408001027	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
179408001028	folate binding site [chemical binding]; other site
179408001029	NADP+ binding site [chemical binding]; other site
179408001030	elongation factor Tu; Region: tufA; CHL00071
179408001031	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
179408001032	G1 box; other site
179408001033	GEF interaction site [polypeptide binding]; other site
179408001034	GTP/Mg2+ binding site [chemical binding]; other site
179408001035	Switch I region; other site
179408001036	G2 box; other site
179408001037	G3 box; other site
179408001038	Switch II region; other site
179408001039	G4 box; other site
179408001040	G5 box; other site
179408001041	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
179408001042	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
179408001043	Antibiotic Binding Site [chemical binding]; other site
179408001044	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
179408001045	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
179408001046	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
179408001047	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
179408001048	metal ion-dependent adhesion site (MIDAS); other site
179408001049	putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208
179408001050	oligomer interface [polypeptide binding]; other site
179408001051	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
179408001052	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408001053	putative active site [active]
179408001054	Protein of unknown function (DUF433); Region: DUF433; pfam04255
179408001055	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
179408001056	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
179408001057	ATP binding site [chemical binding]; other site
179408001058	substrate interface [chemical binding]; other site
179408001059	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408001060	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408001061	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
179408001062	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
179408001063	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
179408001064	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
179408001065	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408001066	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408001067	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
179408001068	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
179408001069	Walker A/P-loop; other site
179408001070	ATP binding site [chemical binding]; other site
179408001071	Q-loop/lid; other site
179408001072	ABC transporter signature motif; other site
179408001073	Walker B; other site
179408001074	D-loop; other site
179408001075	H-loop/switch region; other site
179408001076	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
179408001077	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
179408001078	Walker A/P-loop; other site
179408001079	ATP binding site [chemical binding]; other site
179408001080	Q-loop/lid; other site
179408001081	ABC transporter signature motif; other site
179408001082	Walker B; other site
179408001083	D-loop; other site
179408001084	H-loop/switch region; other site
179408001085	EamA-like transporter family; Region: EamA; cl17759
179408001086	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
179408001087	EamA-like transporter family; Region: EamA; cl17759
179408001088	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
179408001089	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
179408001090	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
179408001091	Predicted ATPases [General function prediction only]; Region: COG1106
179408001092	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408001093	Walker A/P-loop; other site
179408001094	ATP binding site [chemical binding]; other site
179408001095	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408001096	ABC transporter signature motif; other site
179408001097	Walker B; other site
179408001098	D-loop; other site
179408001099	H-loop/switch region; other site
179408001100	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645
179408001101	ATP-NAD kinase; Region: NAD_kinase; pfam01513
179408001102	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
179408001103	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
179408001104	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
179408001105	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
179408001106	active site
179408001107	oxyanion hole [active]
179408001108	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
179408001109	Domain of unknown function DUF21; Region: DUF21; pfam01595
179408001110	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
179408001111	Transporter associated domain; Region: CorC_HlyC; smart01091
179408001112	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
179408001113	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
179408001114	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
179408001115	ATP binding site [chemical binding]; other site
179408001116	putative Mg++ binding site [ion binding]; other site
179408001117	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
179408001118	nucleotide binding region [chemical binding]; other site
179408001119	ATP-binding site [chemical binding]; other site
179408001120	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
179408001121	S-layer homology domain; Region: SLH; pfam00395
179408001122	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
179408001123	heme binding pocket [chemical binding]; other site
179408001124	heme ligand [chemical binding]; other site
179408001125	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
179408001126	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408001127	Mg2+ binding site [ion binding]; other site
179408001128	G-X-G motif; other site
179408001129	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
179408001130	anchoring element; other site
179408001131	dimer interface [polypeptide binding]; other site
179408001132	ATP binding site [chemical binding]; other site
179408001133	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
179408001134	active site
179408001135	putative metal-binding site [ion binding]; other site
179408001136	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
179408001137	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
179408001138	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
179408001139	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408001140	putative active site [active]
179408001141	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408001142	putative active site [active]
179408001143	TMAO/DMSO reductase; Reviewed; Region: PRK05363
179408001144	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
179408001145	Moco binding site; other site
179408001146	metal coordination site [ion binding]; other site
179408001147	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408001148	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408001149	active site
179408001150	ATP binding site [chemical binding]; other site
179408001151	substrate binding site [chemical binding]; other site
179408001152	activation loop (A-loop); other site
179408001153	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408001154	WD40 repeats; Region: WD40; smart00320
179408001155	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408001156	structural tetrad; other site
179408001157	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
179408001158	Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253
179408001159	NAD(P) binding site [chemical binding]; other site
179408001160	short chain dehydrogenase; Provisional; Region: PRK12939
179408001161	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
179408001162	NADP binding site [chemical binding]; other site
179408001163	homodimer interface [polypeptide binding]; other site
179408001164	active site
179408001165	substrate binding site [chemical binding]; other site
179408001166	TPR repeat; Region: TPR_11; pfam13414
179408001167	TPR repeat; Region: TPR_11; pfam13414
179408001168	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408001169	binding surface
179408001170	TPR motif; other site
179408001171	TPR repeat; Region: TPR_11; pfam13414
179408001172	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408001173	binding surface
179408001174	TPR motif; other site
179408001175	Protein of unknown function (DUF3288); Region: DUF3288; pfam11691
179408001176	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
179408001177	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
179408001178	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902
179408001179	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
179408001180	ATP binding site [chemical binding]; other site
179408001181	putative Mg++ binding site [ion binding]; other site
179408001182	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
179408001183	ribonuclease Z; Region: RNase_Z; TIGR02651
179408001184	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
179408001185	Stage II sporulation protein; Region: SpoIID; pfam08486
179408001186	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
179408001187	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
179408001188	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408001189	binding surface
179408001190	TPR motif; other site
179408001191	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
179408001192	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
179408001193	TrkA-N domain; Region: TrkA_N; pfam02254
179408001194	TrkA-C domain; Region: TrkA_C; pfam02080
179408001195	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
179408001196	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
179408001197	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
179408001198	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
179408001199	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
179408001200	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
179408001201	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
179408001202	motif II; other site
179408001203	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
179408001204	BON domain; Region: BON; pfam04972
179408001205	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
179408001206	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408001207	active site
179408001208	phosphorylation site [posttranslational modification]
179408001209	intermolecular recognition site; other site
179408001210	dimerization interface [polypeptide binding]; other site
179408001211	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
179408001212	DNA binding site [nucleotide binding]
179408001213	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408001214	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408001215	dimer interface [polypeptide binding]; other site
179408001216	phosphorylation site [posttranslational modification]
179408001217	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408001218	ATP binding site [chemical binding]; other site
179408001219	Mg2+ binding site [ion binding]; other site
179408001220	G-X-G motif; other site
179408001221	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
179408001222	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
179408001223	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
179408001224	active site
179408001225	catalytic tetrad [active]
179408001226	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408001227	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408001228	active site
179408001229	ATP binding site [chemical binding]; other site
179408001230	substrate binding site [chemical binding]; other site
179408001231	activation loop (A-loop); other site
179408001232	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408001233	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408001234	structural tetrad; other site
179408001235	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
179408001236	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
179408001237	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
179408001238	DNA binding residues [nucleotide binding]
179408001239	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
179408001240	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
179408001241	SnoaL-like domain; Region: SnoaL_3; pfam13474
179408001242	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
179408001243	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
179408001244	dimer interface [polypeptide binding]; other site
179408001245	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
179408001246	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
179408001247	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
179408001248	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
179408001249	Protein of unknown function (DUF433); Region: DUF433; pfam04255
179408001250	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
179408001251	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
179408001252	TM-ABC transporter signature motif; other site
179408001253	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
179408001254	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
179408001255	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
179408001256	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
179408001257	TM-ABC transporter signature motif; other site
179408001258	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_13; cd06348
179408001259	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
179408001260	putative ligand binding site [chemical binding]; other site
179408001261	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
179408001262	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
179408001263	putative acyl-acceptor binding pocket; other site
179408001264	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
179408001265	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408001266	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408001267	Probable transposase; Region: OrfB_IS605; pfam01385
179408001268	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408001269	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
179408001270	CHASE4 domain; Region: CHASE4; pfam05228
179408001271	PAS domain S-box; Region: sensory_box; TIGR00229
179408001272	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408001273	putative active site [active]
179408001274	heme pocket [chemical binding]; other site
179408001275	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408001276	GAF domain; Region: GAF_3; pfam13492
179408001277	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408001278	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408001279	dimer interface [polypeptide binding]; other site
179408001280	phosphorylation site [posttranslational modification]
179408001281	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408001282	ATP binding site [chemical binding]; other site
179408001283	Mg2+ binding site [ion binding]; other site
179408001284	G-X-G motif; other site
179408001285	Response regulator receiver domain; Region: Response_reg; pfam00072
179408001286	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408001287	active site
179408001288	phosphorylation site [posttranslational modification]
179408001289	intermolecular recognition site; other site
179408001290	dimerization interface [polypeptide binding]; other site
179408001291	Response regulator receiver domain; Region: Response_reg; pfam00072
179408001292	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408001293	active site
179408001294	phosphorylation site [posttranslational modification]
179408001295	intermolecular recognition site; other site
179408001296	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408001297	active site
179408001298	dimerization interface [polypeptide binding]; other site
179408001299	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
179408001300	putative binding surface; other site
179408001301	active site
179408001302	WYL domain; Region: WYL; pfam13280
179408001303	CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577
179408001304	CRISPR-associated protein; Region: DUF3692; pfam12469
179408001305	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
179408001306	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075
179408001307	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
179408001308	Transposase IS200 like; Region: Y1_Tnp; cl00848
179408001309	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408001310	putative active site [active]
179408001311	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
179408001312	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
179408001313	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408001314	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408001315	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
179408001316	putative active site [active]
179408001317	putative NTP binding site [chemical binding]; other site
179408001318	putative nucleic acid binding site [nucleotide binding]; other site
179408001319	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408001320	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408001321	active site
179408001322	RRXRR protein; Region: RRXRR; pfam14239
179408001323	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408001324	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408001325	active site
179408001326	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
179408001327	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
179408001328	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
179408001329	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
179408001330	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
179408001331	DNA binding residues [nucleotide binding]
179408001332	dimerization interface [polypeptide binding]; other site
179408001333	Protein of unknown function (DUF1036); Region: DUF1036; cl02296
179408001334	Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480
179408001335	active site
179408001336	catalytic triad [active]
179408001337	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
179408001338	integral membrane protein MviN; Region: mviN; TIGR01695
179408001339	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
179408001340	Protein of unknown function (DUF3181); Region: DUF3181; pfam11378
179408001341	2TM domain; Region: 2TM; pfam13239
179408001342	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
179408001343	trimer interface [polypeptide binding]; other site
179408001344	dimer interface [polypeptide binding]; other site
179408001345	putative active site [active]
179408001346	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
179408001347	putative substrate translocation pore; other site
179408001348	Major Facilitator Superfamily; Region: MFS_1; pfam07690
179408001349	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
179408001350	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408001351	Predicted membrane protein [Function unknown]; Region: COG3463
179408001352	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
179408001353	adaptive-response sensory kinase; Validated; Region: PRK09303
179408001354	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
179408001355	tetramer interface [polypeptide binding]; other site
179408001356	dimer interface [polypeptide binding]; other site
179408001357	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408001358	ATP binding site [chemical binding]; other site
179408001359	Mg2+ binding site [ion binding]; other site
179408001360	G-X-G motif; other site
179408001361	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
179408001362	active site
179408001363	8-oxo-dGMP binding site [chemical binding]; other site
179408001364	nudix motif; other site
179408001365	metal binding site [ion binding]; metal-binding site
179408001366	Protein of unknown function (DUF760); Region: DUF760; pfam05542
179408001367	RNA polymerase sigma factor SigD; Validated; Region: PRK07405
179408001368	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
179408001369	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
179408001370	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
179408001371	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
179408001372	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
179408001373	DNA binding residues [nucleotide binding]
179408001374	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
179408001375	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
179408001376	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
179408001377	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
179408001378	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
179408001379	Protein of unknown function (DUF3464); Region: DUF3464; pfam11947
179408001380	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
179408001381	16S/18S rRNA binding site [nucleotide binding]; other site
179408001382	S13e-L30e interaction site [polypeptide binding]; other site
179408001383	25S rRNA binding site [nucleotide binding]; other site
179408001384	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
179408001385	GIY-YIG motif/motif A; other site
179408001386	active site
179408001387	catalytic site [active]
179408001388	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
179408001389	RuvA N terminal domain; Region: RuvA_N; pfam01330
179408001390	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
179408001391	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
179408001392	GUN4-like; Region: GUN4; pfam05419
179408001393	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408001394	putative active site [active]
179408001395	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408001396	AAA domain; Region: AAA_22; pfam13401
179408001397	Walker A motif; other site
179408001398	ATP binding site [chemical binding]; other site
179408001399	Walker B motif; other site
179408001400	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408001401	TPR motif; other site
179408001402	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408001403	binding surface
179408001404	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408001405	TPR motif; other site
179408001406	binding surface
179408001407	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408001408	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408001409	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408001410	binding surface
179408001411	TPR motif; other site
179408001412	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
179408001413	Uncharacterized conserved protein [Function unknown]; Region: COG2442
179408001414	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
179408001415	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
179408001416	Protein of unknown function (DUF790); Region: DUF790; pfam05626
179408001417	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
179408001418	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
179408001419	ATP binding site [chemical binding]; other site
179408001420	putative Mg++ binding site [ion binding]; other site
179408001421	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
179408001422	nucleotide binding region [chemical binding]; other site
179408001423	ATP-binding site [chemical binding]; other site
179408001424	Methyltransferase domain; Region: Methyltransf_24; pfam13578
179408001425	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
179408001426	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
179408001427	hexamer interface [polypeptide binding]; other site
179408001428	ligand binding site [chemical binding]; other site
179408001429	putative active site [active]
179408001430	NAD(P) binding site [chemical binding]; other site
179408001431	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
179408001432	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
179408001433	C-terminal domain interface [polypeptide binding]; other site
179408001434	GSH binding site (G-site) [chemical binding]; other site
179408001435	dimer interface [polypeptide binding]; other site
179408001436	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
179408001437	N-terminal domain interface [polypeptide binding]; other site
179408001438	dimer interface [polypeptide binding]; other site
179408001439	substrate binding pocket (H-site) [chemical binding]; other site
179408001440	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
179408001441	oligomeric interface; other site
179408001442	putative active site [active]
179408001443	homodimer interface [polypeptide binding]; other site
179408001444	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
179408001445	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
179408001446	ring oligomerisation interface [polypeptide binding]; other site
179408001447	ATP/Mg binding site [chemical binding]; other site
179408001448	stacking interactions; other site
179408001449	hinge regions; other site
179408001450	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
179408001451	oligomerisation interface [polypeptide binding]; other site
179408001452	mobile loop; other site
179408001453	roof hairpin; other site
179408001454	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
179408001455	dimer interface [polypeptide binding]; other site
179408001456	[2Fe-2S] cluster binding site [ion binding]; other site
179408001457	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
179408001458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408001459	active site
179408001460	phosphorylation site [posttranslational modification]
179408001461	intermolecular recognition site; other site
179408001462	dimerization interface [polypeptide binding]; other site
179408001463	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
179408001464	DNA binding residues [nucleotide binding]
179408001465	dimerization interface [polypeptide binding]; other site
179408001466	Uncharacterized conserved protein [Function unknown]; Region: COG1432
179408001467	LabA_like proteins; Region: LabA; cd10911
179408001468	putative metal binding site [ion binding]; other site
179408001469	2-isopropylmalate synthase; Validated; Region: PRK00915
179408001470	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
179408001471	active site
179408001472	catalytic residues [active]
179408001473	metal binding site [ion binding]; metal-binding site
179408001474	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
179408001475	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408001476	S-adenosylmethionine binding site [chemical binding]; other site
179408001477	Protein of unknown function DUF104; Region: DUF104; pfam01954
179408001478	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
179408001479	putative active site [active]
179408001480	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
179408001481	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
179408001482	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408001483	homodimer interface [polypeptide binding]; other site
179408001484	catalytic residue [active]
179408001485	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
179408001486	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
179408001487	active site
179408001488	catalytic site [active]
179408001489	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
179408001490	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
179408001491	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
179408001492	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
179408001493	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408001494	binding surface
179408001495	TPR motif; other site
179408001496	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408001497	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
179408001498	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
179408001499	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
179408001500	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
179408001501	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
179408001502	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
179408001503	Walker A/P-loop; other site
179408001504	ATP binding site [chemical binding]; other site
179408001505	Q-loop/lid; other site
179408001506	ABC transporter signature motif; other site
179408001507	Walker B; other site
179408001508	D-loop; other site
179408001509	H-loop/switch region; other site
179408001510	NurA nuclease; Region: NurA; smart00933
179408001511	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
179408001512	active site
179408001513	motif I; other site
179408001514	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
179408001515	motif II; other site
179408001516	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
179408001517	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
179408001518	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
179408001519	CHASE2 domain; Region: CHASE2; pfam05226
179408001520	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408001521	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408001522	Probable transposase; Region: OrfB_IS605; pfam01385
179408001523	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408001524	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
179408001525	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
179408001526	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
179408001527	Photosystem II protein Y (PsbY); Region: PsbY; pfam06298
179408001528	4-alpha-glucanotransferase; Provisional; Region: PRK14508
179408001529	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
179408001530	Helix-turn-helix domain; Region: HTH_25; pfam13413
179408001531	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
179408001532	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
179408001533	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
179408001534	RNA binding surface [nucleotide binding]; other site
179408001535	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
179408001536	active site
179408001537	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
179408001538	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
179408001539	phosphatidate cytidylyltransferase; Region: PLN02953
179408001540	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
179408001541	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408001542	S-adenosylmethionine binding site [chemical binding]; other site
179408001543	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
179408001544	homodimer interface [polypeptide binding]; other site
179408001545	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408001546	catalytic residue [active]
179408001547	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
179408001548	Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538
179408001549	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
179408001550	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408001551	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408001552	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
179408001553	catalytic residue [active]
179408001554	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408001555	structural tetrad; other site
179408001556	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
179408001557	Caspase domain; Region: Peptidase_C14; pfam00656
179408001558	AAA ATPase domain; Region: AAA_16; pfam13191
179408001559	WD domain, G-beta repeat; Region: WD40; pfam00400
179408001560	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408001561	structural tetrad; other site
179408001562	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408001563	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408001564	structural tetrad; other site
179408001565	Caspase domain; Region: Peptidase_C14; pfam00656
179408001566	PGAP1-like protein; Region: PGAP1; pfam07819
179408001567	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408001568	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
179408001569	putative active site [active]
179408001570	GTP-binding protein YchF; Reviewed; Region: PRK09601
179408001571	YchF GTPase; Region: YchF; cd01900
179408001572	G1 box; other site
179408001573	GTP/Mg2+ binding site [chemical binding]; other site
179408001574	Switch I region; other site
179408001575	G2 box; other site
179408001576	Switch II region; other site
179408001577	G3 box; other site
179408001578	G4 box; other site
179408001579	G5 box; other site
179408001580	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
179408001581	Predicted membrane protein [Function unknown]; Region: COG1950
179408001582	Protein of unknown function (DUF3531); Region: DUF3531; pfam12049
179408001583	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408001584	TPR motif; other site
179408001585	binding surface
179408001586	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
179408001587	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
179408001588	Walker A/P-loop; other site
179408001589	ATP binding site [chemical binding]; other site
179408001590	Q-loop/lid; other site
179408001591	ABC transporter signature motif; other site
179408001592	Walker B; other site
179408001593	D-loop; other site
179408001594	H-loop/switch region; other site
179408001595	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
179408001596	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
179408001597	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
179408001598	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
179408001599	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
179408001600	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
179408001601	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
179408001602	active site
179408001603	catalytic tetrad [active]
179408001604	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
179408001605	tetramer (dimer of dimers) interface [polypeptide binding]; other site
179408001606	active site
179408001607	dimer interface [polypeptide binding]; other site
179408001608	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408001609	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
179408001610	TPR repeat; Region: TPR_11; pfam13414
179408001611	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408001612	binding surface
179408001613	TPR motif; other site
179408001614	TPR repeat; Region: TPR_11; pfam13414
179408001615	TPR repeat; Region: TPR_11; pfam13414
179408001616	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408001617	binding surface
179408001618	TPR motif; other site
179408001619	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408001620	binding surface
179408001621	TPR motif; other site
179408001622	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
179408001623	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408001624	binding surface
179408001625	TPR motif; other site
179408001626	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408001627	binding surface
179408001628	TPR motif; other site
179408001629	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408001630	binding surface
179408001631	TPR motif; other site
179408001632	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
179408001633	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408001634	binding surface
179408001635	TPR motif; other site
179408001636	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635
179408001637	PAS domain; Region: PAS_9; pfam13426
179408001638	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408001639	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408001640	PAS fold; Region: PAS_4; pfam08448
179408001641	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408001642	putative active site [active]
179408001643	heme pocket [chemical binding]; other site
179408001644	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408001645	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408001646	putative active site [active]
179408001647	heme pocket [chemical binding]; other site
179408001648	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408001649	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408001650	putative active site [active]
179408001651	heme pocket [chemical binding]; other site
179408001652	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408001653	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408001654	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408001655	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408001656	metal binding site [ion binding]; metal-binding site
179408001657	active site
179408001658	I-site; other site
179408001659	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
179408001660	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
179408001661	transmembrane helices; other site
179408001662	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
179408001663	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
179408001664	active site
179408001665	catalytic site [active]
179408001666	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
179408001667	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
179408001668	photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655
179408001669	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
179408001670	OstA-like protein; Region: OstA; cl00844
179408001671	Protein of unknown function (DUF3769); Region: DUF3769; pfam12600
179408001672	CpeS-like protein; Region: CpeS; pfam09367
179408001673	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408001674	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408001675	structural tetrad; other site
179408001676	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408001677	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408001678	structural tetrad; other site
179408001679	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
179408001680	structural tetrad; other site
179408001681	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408001682	putative active site [active]
179408001683	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408001684	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
179408001685	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408001686	putative active site [active]
179408001687	putative NTP binding site [chemical binding]; other site
179408001688	putative nucleic acid binding site [nucleotide binding]; other site
179408001689	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408001690	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408001691	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408001692	active site
179408001693	Transposase IS200 like; Region: Y1_Tnp; pfam01797
179408001694	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
179408001695	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
179408001696	Cysteine-rich domain; Region: CCG; pfam02754
179408001697	Cysteine-rich domain; Region: CCG; pfam02754
179408001698	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
179408001699	FAD binding domain; Region: FAD_binding_4; pfam01565
179408001700	circadian clock protein KaiC; Reviewed; Region: PRK09302
179408001701	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
179408001702	Walker A motif; other site
179408001703	ATP binding site [chemical binding]; other site
179408001704	Walker B motif; other site
179408001705	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
179408001706	Walker A motif; other site
179408001707	ATP binding site [chemical binding]; other site
179408001708	Walker B motif; other site
179408001709	Response regulator receiver domain; Region: Response_reg; pfam00072
179408001710	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408001711	active site
179408001712	phosphorylation site [posttranslational modification]
179408001713	dimerization interface [polypeptide binding]; other site
179408001714	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408001715	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
179408001716	dimer interface [polypeptide binding]; other site
179408001717	phosphorylation site [posttranslational modification]
179408001718	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408001719	ATP binding site [chemical binding]; other site
179408001720	Mg2+ binding site [ion binding]; other site
179408001721	G-X-G motif; other site
179408001722	DALR anticodon binding domain; Region: DALR_1; smart00836
179408001723	anticodon binding site; other site
179408001724	tRNA binding surface [nucleotide binding]; other site
179408001725	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
179408001726	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
179408001727	putative switch regulator; other site
179408001728	non-specific DNA interactions [nucleotide binding]; other site
179408001729	DNA binding site [nucleotide binding]
179408001730	sequence specific DNA binding site [nucleotide binding]; other site
179408001731	putative cAMP binding site [chemical binding]; other site
179408001732	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
179408001733	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
179408001734	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
179408001735	motif II; other site
179408001736	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
179408001737	intersubunit interface [polypeptide binding]; other site
179408001738	active site
179408001739	Zn2+ binding site [ion binding]; other site
179408001740	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
179408001741	active site
179408001742	nucleophile elbow; other site
179408001743	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
179408001744	Permease; Region: Permease; cl00510
179408001745	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
179408001746	active site
179408001747	catalytic triad [active]
179408001748	oxyanion hole [active]
179408001749	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
179408001750	catalytic residue [active]
179408001751	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
179408001752	NADH(P)-binding; Region: NAD_binding_10; pfam13460
179408001753	NAD(P) binding site [chemical binding]; other site
179408001754	putative active site [active]
179408001755	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
179408001756	PAS fold; Region: PAS_7; pfam12860
179408001757	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408001758	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408001759	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408001760	dimer interface [polypeptide binding]; other site
179408001761	phosphorylation site [posttranslational modification]
179408001762	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408001763	ATP binding site [chemical binding]; other site
179408001764	Mg2+ binding site [ion binding]; other site
179408001765	G-X-G motif; other site
179408001766	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408001767	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408001768	active site
179408001769	phosphorylation site [posttranslational modification]
179408001770	intermolecular recognition site; other site
179408001771	dimerization interface [polypeptide binding]; other site
179408001772	Response regulator receiver domain; Region: Response_reg; pfam00072
179408001773	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408001774	active site
179408001775	phosphorylation site [posttranslational modification]
179408001776	intermolecular recognition site; other site
179408001777	dimerization interface [polypeptide binding]; other site
179408001778	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
179408001779	cyclase homology domain; Region: CHD; cd07302
179408001780	nucleotidyl binding site; other site
179408001781	metal binding site [ion binding]; metal-binding site
179408001782	dimer interface [polypeptide binding]; other site
179408001783	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
179408001784	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
179408001785	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
179408001786	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
179408001787	putative C-terminal domain interface [polypeptide binding]; other site
179408001788	putative GSH binding site (G-site) [chemical binding]; other site
179408001789	putative dimer interface [polypeptide binding]; other site
179408001790	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
179408001791	putative N-terminal domain interface [polypeptide binding]; other site
179408001792	putative dimer interface [polypeptide binding]; other site
179408001793	putative substrate binding pocket (H-site) [chemical binding]; other site
179408001794	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
179408001795	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408001796	active site
179408001797	phosphorylation site [posttranslational modification]
179408001798	intermolecular recognition site; other site
179408001799	dimerization interface [polypeptide binding]; other site
179408001800	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
179408001801	DNA binding site [nucleotide binding]
179408001802	phosphodiesterase YaeI; Provisional; Region: PRK11340
179408001803	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
179408001804	putative active site [active]
179408001805	putative metal binding site [ion binding]; other site
179408001806	methionine sulfoxide reductase A; Provisional; Region: PRK13014
179408001807	DNA polymerase III subunit delta'; Validated; Region: PRK07399
179408001808	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408001809	Walker A motif; other site
179408001810	ATP binding site [chemical binding]; other site
179408001811	Walker B motif; other site
179408001812	arginine finger; other site
179408001813	thymidylate kinase; Validated; Region: tmk; PRK00698
179408001814	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
179408001815	TMP-binding site; other site
179408001816	ATP-binding site [chemical binding]; other site
179408001817	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
179408001818	metal-binding site [ion binding]
179408001819	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
179408001820	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
179408001821	Soluble P-type ATPase [General function prediction only]; Region: COG4087
179408001822	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
179408001823	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
179408001824	C-terminal peptidase (prc); Region: prc; TIGR00225
179408001825	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
179408001826	protein binding site [polypeptide binding]; other site
179408001827	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
179408001828	Catalytic dyad [active]
179408001829	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
179408001830	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
179408001831	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
179408001832	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408001833	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408001834	active site
179408001835	ATP binding site [chemical binding]; other site
179408001836	substrate binding site [chemical binding]; other site
179408001837	activation loop (A-loop); other site
179408001838	GUN4-like; Region: GUN4; pfam05419
179408001839	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
179408001840	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
179408001841	PemK-like protein; Region: PemK; cl00995
179408001842	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408001843	putative active site [active]
179408001844	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
179408001845	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
179408001846	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
179408001847	Family of unknown function (DUF490); Region: DUF490; pfam04357
179408001848	Protein of unknown function (DUF3110); Region: DUF3110; pfam11360
179408001849	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
179408001850	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
179408001851	putative active site [active]
179408001852	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
179408001853	AAA domain; Region: AAA_17; pfam13207
179408001854	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
179408001855	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
179408001856	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408001857	HEAT repeats; Region: HEAT_2; pfam13646
179408001858	HEAT repeats; Region: HEAT_2; pfam13646
179408001859	FOG: CBS domain [General function prediction only]; Region: COG0517
179408001860	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
179408001861	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
179408001862	dimer interface [polypeptide binding]; other site
179408001863	[2Fe-2S] cluster binding site [ion binding]; other site
179408001864	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
179408001865	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
179408001866	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
179408001867	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
179408001868	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
179408001869	putative substrate translocation pore; other site
179408001870	recombinase A; Provisional; Region: recA; PRK09354
179408001871	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
179408001872	hexamer interface [polypeptide binding]; other site
179408001873	Walker A motif; other site
179408001874	ATP binding site [chemical binding]; other site
179408001875	Walker B motif; other site
179408001876	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
179408001877	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
179408001878	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
179408001879	Catalytic site [active]
179408001880	dihydroorotase; Provisional; Region: PRK07575
179408001881	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
179408001882	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
179408001883	active site
179408001884	Uncharacterized conserved protein [Function unknown]; Region: COG2442
179408001885	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
179408001886	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
179408001887	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
179408001888	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
179408001889	phosphate binding site [ion binding]; other site
179408001890	putative substrate binding pocket [chemical binding]; other site
179408001891	dimer interface [polypeptide binding]; other site
179408001892	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
179408001893	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
179408001894	Walker A/P-loop; other site
179408001895	ATP binding site [chemical binding]; other site
179408001896	Q-loop/lid; other site
179408001897	ABC transporter signature motif; other site
179408001898	Walker B; other site
179408001899	D-loop; other site
179408001900	H-loop/switch region; other site
179408001901	mce related protein; Region: MCE; pfam02470
179408001902	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408001903	putative active site [active]
179408001904	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408001905	putative active site [active]
179408001906	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
179408001907	TPR motif; other site
179408001908	binding surface
179408001909	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
179408001910	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
179408001911	Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301
179408001912	GDP-Fucose binding site [chemical binding]; other site
179408001913	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
179408001914	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408001915	TPR repeat; Region: TPR_11; pfam13414
179408001916	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
179408001917	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
179408001918	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
179408001919	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408001920	S-adenosylmethionine binding site [chemical binding]; other site
179408001921	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
179408001922	Domain of unknown function DUF20; Region: UPF0118; pfam01594
179408001923	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408001924	putative active site [active]
179408001925	Domain of unknown function DUF39; Region: DUF39; pfam01837
179408001926	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
179408001927	TPR motif; other site
179408001928	binding surface
179408001929	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408001930	Tetratricopeptide repeat; Region: TPR_16; pfam13432
179408001931	TPR motif; other site
179408001932	Putative restriction endonuclease; Region: Uma2; pfam05685
179408001933	putative active site [active]
179408001934	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408001935	Response regulator receiver domain; Region: Response_reg; pfam00072
179408001936	active site
179408001937	phosphorylation site [posttranslational modification]
179408001938	intermolecular recognition site; other site
179408001939	dimerization interface [polypeptide binding]; other site
179408001940	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
179408001941	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945
179408001942	L-aspartate oxidase; Provisional; Region: PRK06175
179408001943	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
179408001944	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408001945	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
179408001946	Probable transposase; Region: OrfB_IS605; pfam01385
179408001947	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408001948	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
179408001949	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
179408001950	putative acyl-acceptor binding pocket; other site
179408001951	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
179408001952	Protein of unknown function (DUF2996); Region: DUF2996; pfam11210
179408001953	photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877
179408001954	photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704
179408001955	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
179408001956	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
179408001957	Probable Catalytic site; other site
179408001958	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
179408001959	quinolinate synthetase; Provisional; Region: PRK09375
179408001960	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
179408001961	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
179408001962	ATP binding site [chemical binding]; other site
179408001963	Domain of unknown function (DUF3893); Region: DUF3893; pfam13032
179408001964	Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397
179408001965	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
179408001966	putative active site [active]
179408001967	putative metal binding site [ion binding]; other site
179408001968	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
179408001969	D5 N terminal like; Region: D5_N; cl07360
179408001970	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
179408001971	Uncharacterized subfamily of  glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798
179408001972	active site
179408001973	catalytic site [active]
179408001974	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
179408001975	active site
179408001976	DNA binding site [nucleotide binding]
179408001977	NDF6 (NDH-dependent flow 6); Provisional; Region: PLN00180
179408001978	Gammaherpesvirus latent membrane protein (LMP2) protein; Region: Herpes_LMP2; pfam07415
179408001979	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
179408001980	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408001981	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
179408001982	Coenzyme A binding pocket [chemical binding]; other site
179408001983	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
179408001984	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
179408001985	Protein of unknown function (DUF3727); Region: DUF3727; pfam12527
179408001986	YceG-like family; Region: YceG; pfam02618
179408001987	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
179408001988	dimerization interface [polypeptide binding]; other site
179408001989	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
179408001990	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
179408001991	active site
179408001992	motif I; other site
179408001993	motif II; other site
179408001994	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
179408001995	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
179408001996	catalytic core [active]
179408001997	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
179408001998	catalytic core [active]
179408001999	dihydroorotase; Provisional; Region: PRK07369
179408002000	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
179408002001	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
179408002002	active site
179408002003	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
179408002004	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
179408002005	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
179408002006	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
179408002007	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408002008	active site
179408002009	phosphorylation site [posttranslational modification]
179408002010	intermolecular recognition site; other site
179408002011	dimerization interface [polypeptide binding]; other site
179408002012	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
179408002013	DNA binding site [nucleotide binding]
179408002014	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
179408002015	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
179408002016	active site
179408002017	multimer interface [polypeptide binding]; other site
179408002018	gamma-glutamyl kinase; Provisional; Region: PRK05429
179408002019	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
179408002020	nucleotide binding site [chemical binding]; other site
179408002021	homotetrameric interface [polypeptide binding]; other site
179408002022	putative phosphate binding site [ion binding]; other site
179408002023	putative allosteric binding site; other site
179408002024	PUA domain; Region: PUA; pfam01472
179408002025	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
179408002026	Short C-terminal domain; Region: SHOCT; pfam09851
179408002027	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
179408002028	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
179408002029	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
179408002030	UbiA prenyltransferase family; Region: UbiA; pfam01040
179408002031	Transglycosylase; Region: Transgly; pfam00912
179408002032	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
179408002033	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
179408002034	NusB family; Region: NusB; pfam01029
179408002035	16S rRNA methyltransferase B; Provisional; Region: PRK14901
179408002036	putative RNA binding site [nucleotide binding]; other site
179408002037	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408002038	S-adenosylmethionine binding site [chemical binding]; other site
179408002039	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408002040	putative active site [active]
179408002041	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408002042	putative active site [active]
179408002043	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
179408002044	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
179408002045	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
179408002046	active site
179408002047	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408002048	putative active site [active]
179408002049	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
179408002050	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
179408002051	Cupin domain; Region: Cupin_2; pfam07883
179408002052	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408002053	Coenzyme A binding pocket [chemical binding]; other site
179408002054	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
179408002055	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
179408002056	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
179408002057	dimer interface [polypeptide binding]; other site
179408002058	motif 1; other site
179408002059	active site
179408002060	motif 2; other site
179408002061	motif 3; other site
179408002062	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
179408002063	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
179408002064	Walker A/P-loop; other site
179408002065	ATP binding site [chemical binding]; other site
179408002066	Q-loop/lid; other site
179408002067	ABC transporter signature motif; other site
179408002068	Walker B; other site
179408002069	D-loop; other site
179408002070	H-loop/switch region; other site
179408002071	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
179408002072	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
179408002073	putative substrate translocation pore; other site
179408002074	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
179408002075	H+ Antiporter protein; Region: 2A0121; TIGR00900
179408002076	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
179408002077	putative substrate translocation pore; other site
179408002078	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
179408002079	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
179408002080	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
179408002081	ligand binding site [chemical binding]; other site
179408002082	homodimer interface [polypeptide binding]; other site
179408002083	NAD(P) binding site [chemical binding]; other site
179408002084	trimer interface B [polypeptide binding]; other site
179408002085	trimer interface A [polypeptide binding]; other site
179408002086	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
179408002087	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
179408002088	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
179408002089	YcfA-like protein; Region: YcfA; pfam07927
179408002090	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
179408002091	Fusaric acid resistance protein family; Region: FUSC; pfam04632
179408002092	Protein of unknown function (DUF433); Region: DUF433; pfam04255
179408002093	Uncharacterized conserved protein [Function unknown]; Region: COG2442
179408002094	Uncharacterized conserved protein [Function unknown]; Region: COG1656
179408002095	Protein-arginine deiminase (PAD); Region: PAD; pfam03068
179408002096	Proline dehydrogenase; Region: Pro_dh; pfam01619
179408002097	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
179408002098	delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237
179408002099	Glutamate binding site [chemical binding]; other site
179408002100	homodimer interface [polypeptide binding]; other site
179408002101	NAD binding site [chemical binding]; other site
179408002102	catalytic residues [active]
179408002103	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
179408002104	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
179408002105	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
179408002106	catalytic triad [active]
179408002107	putative active site [active]
179408002108	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
179408002109	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
179408002110	Right handed beta helix region; Region: Beta_helix; pfam13229
179408002111	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408002112	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408002113	Q-loop/lid; other site
179408002114	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
179408002115	ABC transporter signature motif; other site
179408002116	Walker B; other site
179408002117	D-loop; other site
179408002118	H-loop/switch region; other site
179408002119	Protein of unknown function (DUF1190); Region: DUF1190; cl10031
179408002120	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
179408002121	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
179408002122	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
179408002123	Walker A/P-loop; other site
179408002124	ATP binding site [chemical binding]; other site
179408002125	Q-loop/lid; other site
179408002126	ABC transporter signature motif; other site
179408002127	Walker B; other site
179408002128	D-loop; other site
179408002129	H-loop/switch region; other site
179408002130	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
179408002131	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
179408002132	substrate binding pocket [chemical binding]; other site
179408002133	membrane-bound complex binding site; other site
179408002134	hinge residues; other site
179408002135	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
179408002136	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408002137	dimer interface [polypeptide binding]; other site
179408002138	conserved gate region; other site
179408002139	putative PBP binding loops; other site
179408002140	ABC-ATPase subunit interface; other site
179408002141	CRISPR-associated protein; Region: TIGR03986
179408002142	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
179408002143	CRISPR-associated protein, TIGR03984 family; Region: TIGR03984
179408002144	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
179408002145	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
179408002146	CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558
179408002147	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
179408002148	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
179408002149	Domain of unknown function (DUF1887); Region: DUF1887; pfam09002
179408002150	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
179408002151	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
179408002152	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
179408002153	Rhodanese Homology Domain; Region: RHOD; smart00450
179408002154	active site residue [active]
179408002155	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
179408002156	active site residue [active]
179408002157	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
179408002158	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
179408002159	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
179408002160	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
179408002161	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
179408002162	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
179408002163	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
179408002164	Mechanosensitive ion channel; Region: MS_channel; pfam00924
179408002165	EamA-like transporter family; Region: EamA; pfam00892
179408002166	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
179408002167	EamA-like transporter family; Region: EamA; pfam00892
179408002168	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
179408002169	Beta-propeller repeat; Region: SBBP; pfam06739
179408002170	Beta-propeller repeat; Region: SBBP; pfam06739
179408002171	Beta-propeller repeat; Region: SBBP; pfam06739
179408002172	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
179408002173	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
179408002174	active site
179408002175	catalytic residues [active]
179408002176	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
179408002177	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
179408002178	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
179408002179	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
179408002180	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408002181	Probable transposase; Region: OrfB_IS605; pfam01385
179408002182	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408002183	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
179408002184	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
179408002185	interchain domain interface [polypeptide binding]; other site
179408002186	intrachain domain interface; other site
179408002187	Qi binding site; other site
179408002188	Qo binding site; other site
179408002189	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
179408002190	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
179408002191	Qi binding site; other site
179408002192	intrachain domain interface; other site
179408002193	interchain domain interface [polypeptide binding]; other site
179408002194	heme bH binding site [chemical binding]; other site
179408002195	heme bL binding site [chemical binding]; other site
179408002196	Qo binding site; other site
179408002197	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408002198	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
179408002199	Family description; Region: VCBS; pfam13517
179408002200	Family description; Region: VCBS; pfam13517
179408002201	Family description; Region: VCBS; pfam13517
179408002202	Family description; Region: VCBS; pfam13517
179408002203	Family description; Region: VCBS; pfam13517
179408002204	Calx-beta domain; Region: Calx-beta; cl02522
179408002205	Clostripain family; Region: Peptidase_C11; pfam03415
179408002206	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408002207	carboxyl-terminal processing protease; Provisional; Region: PLN00049
179408002208	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
179408002209	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
179408002210	protein binding site [polypeptide binding]; other site
179408002211	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
179408002212	Catalytic dyad [active]
179408002213	Photosystem I protein M (PsaM); Region: PsaM; pfam07465
179408002214	Integral membrane protein TerC family; Region: TerC; cl10468
179408002215	Protein of unknown function (DUF3223); Region: DUF3223; pfam11523
179408002216	XisI protein; Region: XisI; pfam08869
179408002217	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
179408002218	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408002219	Walker A/P-loop; other site
179408002220	ATP binding site [chemical binding]; other site
179408002221	Q-loop/lid; other site
179408002222	ABC transporter signature motif; other site
179408002223	Walker B; other site
179408002224	D-loop; other site
179408002225	H-loop/switch region; other site
179408002226	TOBE domain; Region: TOBE_2; pfam08402
179408002227	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
179408002228	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408002229	ABC-ATPase subunit interface; other site
179408002230	putative PBP binding loops; other site
179408002231	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408002232	dimer interface [polypeptide binding]; other site
179408002233	conserved gate region; other site
179408002234	putative PBP binding loops; other site
179408002235	ABC-ATPase subunit interface; other site
179408002236	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408002237	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408002238	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408002239	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408002240	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408002241	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
179408002242	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
179408002243	glycogen synthase; Provisional; Region: glgA; PRK00654
179408002244	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
179408002245	ADP-binding pocket [chemical binding]; other site
179408002246	homodimer interface [polypeptide binding]; other site
179408002247	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408002248	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408002249	putative active site [active]
179408002250	heme pocket [chemical binding]; other site
179408002251	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408002252	putative active site [active]
179408002253	heme pocket [chemical binding]; other site
179408002254	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408002255	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408002256	putative active site [active]
179408002257	heme pocket [chemical binding]; other site
179408002258	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408002259	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408002260	metal binding site [ion binding]; metal-binding site
179408002261	active site
179408002262	I-site; other site
179408002263	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
179408002264	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
179408002265	M28 Zn-Peptidases; Region: M28_like_1; cd05640
179408002266	Peptidase family M28; Region: Peptidase_M28; pfam04389
179408002267	metal binding site [ion binding]; metal-binding site
179408002268	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
179408002269	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
179408002270	phosphopeptide binding site; other site
179408002271	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
179408002272	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
179408002273	phosphopeptide binding site; other site
179408002274	The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955
179408002275	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
179408002276	Walker A/P-loop; other site
179408002277	ATP binding site [chemical binding]; other site
179408002278	Q-loop/lid; other site
179408002279	ABC transporter signature motif; other site
179408002280	Walker B; other site
179408002281	D-loop; other site
179408002282	H-loop/switch region; other site
179408002283	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
179408002284	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
179408002285	putative hydrophobic ligand binding site [chemical binding]; other site
179408002286	protein interface [polypeptide binding]; other site
179408002287	gate; other site
179408002288	Uncharacterized conserved protein [Function unknown]; Region: COG2947
179408002289	glucokinase, proteobacterial type; Region: glk; TIGR00749
179408002290	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
179408002291	nucleotide binding site [chemical binding]; other site
179408002292	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
179408002293	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
179408002294	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
179408002295	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
179408002296	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
179408002297	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
179408002298	catalytic site [active]
179408002299	active site
179408002300	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
179408002301	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
179408002302	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
179408002303	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
179408002304	active site
179408002305	catalytic site [active]
179408002306	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
179408002307	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408002308	Coenzyme A binding pocket [chemical binding]; other site
179408002309	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
179408002310	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
179408002311	nucleotide binding site [chemical binding]; other site
179408002312	NEF interaction site [polypeptide binding]; other site
179408002313	SBD interface [polypeptide binding]; other site
179408002314	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
179408002315	Predicted transcriptional regulators [Transcription]; Region: COG1695
179408002316	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
179408002317	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
179408002318	E3 interaction surface; other site
179408002319	lipoyl attachment site [posttranslational modification]; other site
179408002320	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
179408002321	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
179408002322	HlyD family secretion protein; Region: HlyD_3; pfam13437
179408002323	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
179408002324	Protein export membrane protein; Region: SecD_SecF; cl14618
179408002325	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
179408002326	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408002327	dimer interface [polypeptide binding]; other site
179408002328	conserved gate region; other site
179408002329	putative PBP binding loops; other site
179408002330	ABC-ATPase subunit interface; other site
179408002331	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
179408002332	dinuclear metal binding motif [ion binding]; other site
179408002333	acyl-ACP reductase; Provisional; Region: PRK14982
179408002334	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
179408002335	NAD(P) binding pocket [chemical binding]; other site
179408002336	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
179408002337	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
179408002338	short chain dehydrogenase; Provisional; Region: PRK07454
179408002339	classical (c) SDRs; Region: SDR_c; cd05233
179408002340	NAD(P) binding site [chemical binding]; other site
179408002341	active site
179408002342	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
179408002343	homodecamer interface [polypeptide binding]; other site
179408002344	GTP cyclohydrolase I; Provisional; Region: PLN03044
179408002345	active site
179408002346	putative catalytic site residues [active]
179408002347	zinc binding site [ion binding]; other site
179408002348	GTP-CH-I/GFRP interaction surface; other site
179408002349	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
179408002350	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
179408002351	active site
179408002352	substrate binding site [chemical binding]; other site
179408002353	metal binding site [ion binding]; metal-binding site
179408002354	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
179408002355	active site
179408002356	dimerization interface [polypeptide binding]; other site
179408002357	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
179408002358	Nitrogen regulatory protein P-II; Region: P-II; smart00938
179408002359	Brix domain; Region: Brix; cl00935
179408002360	H+ Antiporter protein; Region: 2A0121; TIGR00900
179408002361	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
179408002362	putative substrate translocation pore; other site
179408002363	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418
179408002364	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
179408002365	PYR/PP interface [polypeptide binding]; other site
179408002366	dimer interface [polypeptide binding]; other site
179408002367	TPP binding site [chemical binding]; other site
179408002368	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
179408002369	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
179408002370	TPP-binding site [chemical binding]; other site
179408002371	dimer interface [polypeptide binding]; other site
179408002372	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
179408002373	Protein kinase domain; Region: Pkinase; pfam00069
179408002374	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408002375	active site
179408002376	ATP binding site [chemical binding]; other site
179408002377	substrate binding site [chemical binding]; other site
179408002378	activation loop (A-loop); other site
179408002379	GUN4-like; Region: GUN4; pfam05419
179408002380	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
179408002381	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
179408002382	D-xylulose kinase; Region: XylB; TIGR01312
179408002383	nucleotide binding site [chemical binding]; other site
179408002384	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
179408002385	Part of AAA domain; Region: AAA_19; pfam13245
179408002386	Family description; Region: UvrD_C_2; pfam13538
179408002387	Uncharacterized conserved protein [Function unknown]; Region: COG3339
179408002388	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
179408002389	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
179408002390	putative homodimer interface [polypeptide binding]; other site
179408002391	putative active site pocket [active]
179408002392	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
179408002393	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
179408002394	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
179408002395	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
179408002396	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
179408002397	Helix-turn-helix domain; Region: HTH_37; pfam13744
179408002398	photosystem II 47 kDa protein; Region: psbB; CHL00062
179408002399	photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875
179408002400	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
179408002401	ATP cone domain; Region: ATP-cone; pfam03477
179408002402	30S ribosomal protein S1; Reviewed; Region: PRK07400
179408002403	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
179408002404	RNA binding site [nucleotide binding]; other site
179408002405	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
179408002406	RNA binding site [nucleotide binding]; other site
179408002407	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
179408002408	RNA binding site [nucleotide binding]; other site
179408002409	CheB methylesterase; Region: CheB_methylest; pfam01339
179408002410	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
179408002411	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
179408002412	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
179408002413	PAS domain; Region: PAS_9; pfam13426
179408002414	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
179408002415	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408002416	dimer interface [polypeptide binding]; other site
179408002417	phosphorylation site [posttranslational modification]
179408002418	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408002419	ATP binding site [chemical binding]; other site
179408002420	Mg2+ binding site [ion binding]; other site
179408002421	G-X-G motif; other site
179408002422	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408002423	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408002424	active site
179408002425	phosphorylation site [posttranslational modification]
179408002426	intermolecular recognition site; other site
179408002427	dimerization interface [polypeptide binding]; other site
179408002428	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
179408002429	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
179408002430	motif II; other site
179408002431	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
179408002432	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408002433	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
179408002434	Coenzyme A binding pocket [chemical binding]; other site
179408002435	UGMP family protein; Validated; Region: PRK09604
179408002436	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
179408002437	Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627
179408002438	photosystem I reaction center subunit IX; Provisional; Region: PRK02733
179408002439	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
179408002440	nitrilase; Region: PLN02798
179408002441	putative active site [active]
179408002442	catalytic triad [active]
179408002443	dimer interface [polypeptide binding]; other site
179408002444	acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100
179408002445	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
179408002446	putative valine binding site [chemical binding]; other site
179408002447	dimer interface [polypeptide binding]; other site
179408002448	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
179408002449	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408002450	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408002451	putative active site [active]
179408002452	heme pocket [chemical binding]; other site
179408002453	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408002454	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408002455	putative active site [active]
179408002456	heme pocket [chemical binding]; other site
179408002457	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408002458	putative active site [active]
179408002459	heme pocket [chemical binding]; other site
179408002460	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408002461	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408002462	metal binding site [ion binding]; metal-binding site
179408002463	active site
179408002464	I-site; other site
179408002465	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
179408002466	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
179408002467	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
179408002468	putative NAD(P) binding site [chemical binding]; other site
179408002469	Glyco_18 domain; Region: Glyco_18; smart00636
179408002470	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
179408002471	active site
179408002472	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
179408002473	Ribosome inactivating protein; Region: RIP; pfam00161
179408002474	Beta/gamma crystallins; Region: XTALbg; smart00247
179408002475	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
179408002476	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
179408002477	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
179408002478	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
179408002479	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
179408002480	active site
179408002481	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
179408002482	Ligand Binding Site [chemical binding]; other site
179408002483	Molecular Tunnel; other site
179408002484	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
179408002485	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408002486	active site
179408002487	ATP binding site [chemical binding]; other site
179408002488	substrate binding site [chemical binding]; other site
179408002489	activation loop (A-loop); other site
179408002490	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
179408002491	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
179408002492	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
179408002493	putative dimerization interface [polypeptide binding]; other site
179408002494	Predicted membrane protein [Function unknown]; Region: COG4094
179408002495	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
179408002496	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
179408002497	catalytic residues [active]
179408002498	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
179408002499	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
179408002500	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
179408002501	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
179408002502	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546
179408002503	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
179408002504	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408002505	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408002506	binding surface
179408002507	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408002508	TPR motif; other site
179408002509	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408002510	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408002511	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408002512	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
179408002513	binding surface
179408002514	TPR motif; other site
179408002515	clan AA aspartic protease, AF_0612 family; Region: clan_AA_DTGF; TIGR03698
179408002516	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
179408002517	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
179408002518	membrane-bound complex binding site; other site
179408002519	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
179408002520	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408002521	ATP binding site [chemical binding]; other site
179408002522	Mg2+ binding site [ion binding]; other site
179408002523	G-X-G motif; other site
179408002524	Protein of unknown function (DUF2656); Region: DUF2656; pfam10847
179408002525	HEAT repeats; Region: HEAT_2; pfam13646
179408002526	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
179408002527	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
179408002528	protein binding surface [polypeptide binding]; other site
179408002529	HEAT repeats; Region: HEAT_2; pfam13646
179408002530	CpeS-like protein; Region: CpeS; pfam09367
179408002531	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408002532	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408002533	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408002534	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408002535	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408002536	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408002537	Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930
179408002538	dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13247
179408002539	Phycobilisome protein; Region: Phycobilisome; cl08227
179408002540	HEAT repeats; Region: HEAT_2; pfam13646
179408002541	HEAT repeats; Region: HEAT_2; pfam13646
179408002542	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
179408002543	CpcD/allophycocyanin linker domain; Region: CpcD; smart01094
179408002544	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
179408002545	CpcD/allophycocyanin linker domain; Region: CpcD; smart01094
179408002546	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
179408002547	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
179408002548	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
179408002549	CpeS-like protein; Region: CpeS; pfam09367
179408002550	Phycobilisome protein; Region: Phycobilisome; cl08227
179408002551	Phycobilisome protein; Region: Phycobilisome; cl08227
179408002552	HEAT repeats; Region: HEAT_2; pfam13646
179408002553	HEAT repeats; Region: HEAT_2; pfam13646
179408002554	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
179408002555	HEAT repeats; Region: HEAT_2; pfam13646
179408002556	protein binding surface [polypeptide binding]; other site
179408002557	HEAT repeats; Region: HEAT_2; pfam13646
179408002558	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
179408002559	dimerization interface [polypeptide binding]; other site
179408002560	putative DNA binding site [nucleotide binding]; other site
179408002561	putative Zn2+ binding site [ion binding]; other site
179408002562	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
179408002563	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
179408002564	active site residue [active]
179408002565	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
179408002566	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
179408002567	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408002568	active site
179408002569	ATP binding site [chemical binding]; other site
179408002570	substrate binding site [chemical binding]; other site
179408002571	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408002572	activation loop (A-loop); other site
179408002573	AAA ATPase domain; Region: AAA_16; pfam13191
179408002574	Predicted ATPase [General function prediction only]; Region: COG3899
179408002575	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408002576	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408002577	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
179408002578	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408002579	dimer interface [polypeptide binding]; other site
179408002580	phosphorylation site [posttranslational modification]
179408002581	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408002582	ATP binding site [chemical binding]; other site
179408002583	Mg2+ binding site [ion binding]; other site
179408002584	G-X-G motif; other site
179408002585	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408002586	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408002587	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
179408002588	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
179408002589	DNA binding residues [nucleotide binding]
179408002590	dimerization interface [polypeptide binding]; other site
179408002591	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
179408002592	MAPEG family; Region: MAPEG; cl09190
179408002593	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
179408002594	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408002595	active site
179408002596	ATP binding site [chemical binding]; other site
179408002597	substrate binding site [chemical binding]; other site
179408002598	activation loop (A-loop); other site
179408002599	Uncharacterized conserved protein [Function unknown]; Region: COG1262
179408002600	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
179408002601	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
179408002602	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
179408002603	EamA-like transporter family; Region: EamA; pfam00892
179408002604	EamA-like transporter family; Region: EamA; pfam00892
179408002605	peptide synthase; Provisional; Region: PRK12467
179408002606	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
179408002607	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
179408002608	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
179408002609	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
179408002610	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
179408002611	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
179408002612	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
179408002613	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
179408002614	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
179408002615	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
179408002616	putative homodimer interface [polypeptide binding]; other site
179408002617	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
179408002618	heterodimer interface [polypeptide binding]; other site
179408002619	homodimer interface [polypeptide binding]; other site
179408002620	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
179408002621	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
179408002622	23S rRNA interface [nucleotide binding]; other site
179408002623	L7/L12 interface [polypeptide binding]; other site
179408002624	putative thiostrepton binding site; other site
179408002625	L25 interface [polypeptide binding]; other site
179408002626	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
179408002627	mRNA/rRNA interface [nucleotide binding]; other site
179408002628	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
179408002629	23S rRNA interface [nucleotide binding]; other site
179408002630	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
179408002631	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
179408002632	peripheral dimer interface [polypeptide binding]; other site
179408002633	core dimer interface [polypeptide binding]; other site
179408002634	L10 interface [polypeptide binding]; other site
179408002635	L11 interface [polypeptide binding]; other site
179408002636	putative EF-Tu interaction site [polypeptide binding]; other site
179408002637	putative EF-G interaction site [polypeptide binding]; other site
179408002638	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
179408002639	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
179408002640	HEAT repeats; Region: HEAT_2; pfam13646
179408002641	HEAT repeats; Region: HEAT_2; pfam13646
179408002642	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
179408002643	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408002644	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408002645	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
179408002646	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
179408002647	catalytic loop [active]
179408002648	iron binding site [ion binding]; other site
179408002649	Staphylococcal nuclease homologues; Region: SNc; smart00318
179408002650	Catalytic site; other site
179408002651	Staphylococcal nuclease homologue; Region: SNase; pfam00565
179408002652	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
179408002653	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
179408002654	active site
179408002655	dimerization interface [polypeptide binding]; other site
179408002656	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
179408002657	HSP70 interaction site [polypeptide binding]; other site
179408002658	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408002659	TPR repeat; Region: TPR_11; pfam13414
179408002660	binding surface
179408002661	TPR motif; other site
179408002662	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
179408002663	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
179408002664	dimer interface [polypeptide binding]; other site
179408002665	motif 1; other site
179408002666	active site
179408002667	motif 2; other site
179408002668	motif 3; other site
179408002669	Ferredoxin [Energy production and conversion]; Region: COG1146
179408002670	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408002671	putative active site [active]
179408002672	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
179408002673	MPN+ (JAMM) motif; other site
179408002674	Zinc-binding site [ion binding]; other site
179408002675	hypothetical protein; Validated; Region: PRK07411
179408002676	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
179408002677	ATP binding site [chemical binding]; other site
179408002678	substrate interface [chemical binding]; other site
179408002679	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
179408002680	active site residue [active]
179408002681	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
179408002682	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
179408002683	motif 1; other site
179408002684	active site
179408002685	motif 2; other site
179408002686	motif 3; other site
179408002687	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
179408002688	DHHA1 domain; Region: DHHA1; pfam02272
179408002689	Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765
179408002690	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
179408002691	BON domain; Region: BON; pfam04972
179408002692	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
179408002693	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
179408002694	ligand binding site [chemical binding]; other site
179408002695	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
179408002696	Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154
179408002697	Rab subfamily motif 1 (RabSF1); other site
179408002698	G1 box; other site
179408002699	GTP/Mg2+ binding site [chemical binding]; other site
179408002700	Rab subfamily motif 2 (RabSF2); other site
179408002701	Switch I region; other site
179408002702	G2 box; other site
179408002703	effector interaction site; other site
179408002704	GDI interaction site; other site
179408002705	Rab family motif 1 (RabF1); other site
179408002706	GEF interaction site [polypeptide binding]; other site
179408002707	Rab family motif 2 (RabF2); other site
179408002708	G3 box; other site
179408002709	Switch II region; other site
179408002710	Rab family motif 3 (RabF3); other site
179408002711	Rab family motif 4 (RabF4); other site
179408002712	Rab family motif 5 (RabF5); other site
179408002713	Rab subfamily motif 3 (RabSF3); other site
179408002714	G4 box; other site
179408002715	G5 box; other site
179408002716	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408002717	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408002718	putative active site [active]
179408002719	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408002720	heme pocket [chemical binding]; other site
179408002721	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408002722	dimer interface [polypeptide binding]; other site
179408002723	phosphorylation site [posttranslational modification]
179408002724	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408002725	ATP binding site [chemical binding]; other site
179408002726	Mg2+ binding site [ion binding]; other site
179408002727	G-X-G motif; other site
179408002728	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408002729	PAS domain; Region: PAS_9; pfam13426
179408002730	putative active site [active]
179408002731	heme pocket [chemical binding]; other site
179408002732	GAF domain; Region: GAF; cl17456
179408002733	GAF domain; Region: GAF_2; pfam13185
179408002734	PAS domain S-box; Region: sensory_box; TIGR00229
179408002735	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408002736	putative active site [active]
179408002737	heme pocket [chemical binding]; other site
179408002738	PAS fold; Region: PAS_7; pfam12860
179408002739	Heme NO binding associated; Region: HNOBA; pfam07701
179408002740	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
179408002741	cyclase homology domain; Region: CHD; cd07302
179408002742	nucleotidyl binding site; other site
179408002743	metal binding site [ion binding]; metal-binding site
179408002744	dimer interface [polypeptide binding]; other site
179408002745	FOG: CBS domain [General function prediction only]; Region: COG0517
179408002746	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
179408002747	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
179408002748	PAS domain S-box; Region: sensory_box; TIGR00229
179408002749	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408002750	putative active site [active]
179408002751	heme pocket [chemical binding]; other site
179408002752	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408002753	PAS fold; Region: PAS_3; pfam08447
179408002754	putative active site [active]
179408002755	heme pocket [chemical binding]; other site
179408002756	PAS domain S-box; Region: sensory_box; TIGR00229
179408002757	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
179408002758	putative active site [active]
179408002759	heme pocket [chemical binding]; other site
179408002760	PAS domain S-box; Region: sensory_box; TIGR00229
179408002761	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408002762	putative active site [active]
179408002763	heme pocket [chemical binding]; other site
179408002764	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408002765	PAS fold; Region: PAS_3; pfam08447
179408002766	putative active site [active]
179408002767	heme pocket [chemical binding]; other site
179408002768	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408002769	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408002770	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
179408002771	Histidine kinase; Region: HisKA_2; pfam07568
179408002772	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408002773	ATP binding site [chemical binding]; other site
179408002774	Mg2+ binding site [ion binding]; other site
179408002775	G-X-G motif; other site
179408002776	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408002777	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408002778	active site
179408002779	phosphorylation site [posttranslational modification]
179408002780	intermolecular recognition site; other site
179408002781	dimerization interface [polypeptide binding]; other site
179408002782	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408002783	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408002784	dimer interface [polypeptide binding]; other site
179408002785	phosphorylation site [posttranslational modification]
179408002786	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408002787	ATP binding site [chemical binding]; other site
179408002788	Mg2+ binding site [ion binding]; other site
179408002789	G-X-G motif; other site
179408002790	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
179408002791	hydroxyglutarate oxidase; Provisional; Region: PRK11728
179408002792	Predicted membrane protein (DUF2231); Region: DUF2231; pfam09990
179408002793	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408002794	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408002795	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408002796	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408002797	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408002798	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408002799	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408002800	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
179408002801	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
179408002802	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
179408002803	metal ion-dependent adhesion site (MIDAS); other site
179408002804	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
179408002805	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
179408002806	CTP synthetase; Validated; Region: pyrG; PRK05380
179408002807	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
179408002808	Catalytic site [active]
179408002809	active site
179408002810	UTP binding site [chemical binding]; other site
179408002811	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
179408002812	active site
179408002813	putative oxyanion hole; other site
179408002814	catalytic triad [active]
179408002815	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
179408002816	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
179408002817	nucleotide binding site [chemical binding]; other site
179408002818	TPR repeat; Region: TPR_11; pfam13414
179408002819	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408002820	binding surface
179408002821	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
179408002822	MltA specific insert domain; Region: MltA; pfam03562
179408002823	3D domain; Region: 3D; pfam06725
179408002824	Cytochrome P450; Region: p450; cl12078
179408002825	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
179408002826	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
179408002827	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
179408002828	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
179408002829	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
179408002830	ATP-grasp domain; Region: ATP-grasp_4; cl17255
179408002831	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
179408002832	IMP binding site; other site
179408002833	dimer interface [polypeptide binding]; other site
179408002834	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408002835	putative active site [active]
179408002836	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
179408002837	metal ion-dependent adhesion site (MIDAS); other site
179408002838	Protein phosphatase 2C; Region: PP2C_2; pfam13672
179408002839	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
179408002840	dimerization interface [polypeptide binding]; other site
179408002841	active site
179408002842	metal binding site [ion binding]; metal-binding site
179408002843	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258
179408002844	active site
179408002845	metal binding site [ion binding]; metal-binding site
179408002846	dimerization interface [polypeptide binding]; other site
179408002847	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
179408002848	substrate binding site [chemical binding]; other site
179408002849	activation loop (A-loop); other site
179408002850	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
179408002851	MgtC family; Region: MgtC; pfam02308
179408002852	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
179408002853	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
179408002854	DNA binding residues [nucleotide binding]
179408002855	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082
179408002856	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
179408002857	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
179408002858	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
179408002859	Soluble P-type ATPase [General function prediction only]; Region: COG4087
179408002860	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
179408002861	elongation factor G; Reviewed; Region: PRK12740
179408002862	G1 box; other site
179408002863	putative GEF interaction site [polypeptide binding]; other site
179408002864	GTP/Mg2+ binding site [chemical binding]; other site
179408002865	Switch I region; other site
179408002866	G2 box; other site
179408002867	G3 box; other site
179408002868	Switch II region; other site
179408002869	G4 box; other site
179408002870	G5 box; other site
179408002871	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
179408002872	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
179408002873	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
179408002874	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408002875	putative active site [active]
179408002876	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
179408002877	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
179408002878	P loop; other site
179408002879	Nucleotide binding site [chemical binding]; other site
179408002880	DTAP/Switch II; other site
179408002881	Switch I; other site
179408002882	Protein of unknown function (DUF2862); Region: DUF2862; pfam11061
179408002883	FecR protein; Region: FecR; pfam04773
179408002884	CHASE2 domain; Region: CHASE2; pfam05226
179408002885	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
179408002886	cyclase homology domain; Region: CHD; cd07302
179408002887	nucleotidyl binding site; other site
179408002888	metal binding site [ion binding]; metal-binding site
179408002889	dimer interface [polypeptide binding]; other site
179408002890	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
179408002891	glutaminase; Provisional; Region: PRK00971
179408002892	Uncharacterized conserved protein [Function unknown]; Region: COG1434
179408002893	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
179408002894	putative active site [active]
179408002895	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
179408002896	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
179408002897	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
179408002898	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
179408002899	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
179408002900	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
179408002901	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
179408002902	Walker A/P-loop; other site
179408002903	ATP binding site [chemical binding]; other site
179408002904	Q-loop/lid; other site
179408002905	ABC transporter signature motif; other site
179408002906	Walker B; other site
179408002907	D-loop; other site
179408002908	H-loop/switch region; other site
179408002909	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
179408002910	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
179408002911	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
179408002912	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408002913	dimer interface [polypeptide binding]; other site
179408002914	conserved gate region; other site
179408002915	ABC-ATPase subunit interface; other site
179408002916	Cache domain; Region: Cache_1; pfam02743
179408002917	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408002918	dimerization interface [polypeptide binding]; other site
179408002919	PAS fold; Region: PAS_4; pfam08448
179408002920	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408002921	putative active site [active]
179408002922	heme pocket [chemical binding]; other site
179408002923	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408002924	GAF domain; Region: GAF; pfam01590
179408002925	PAS domain S-box; Region: sensory_box; TIGR00229
179408002926	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408002927	putative active site [active]
179408002928	heme pocket [chemical binding]; other site
179408002929	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408002930	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408002931	dimer interface [polypeptide binding]; other site
179408002932	phosphorylation site [posttranslational modification]
179408002933	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408002934	ATP binding site [chemical binding]; other site
179408002935	Mg2+ binding site [ion binding]; other site
179408002936	G-X-G motif; other site
179408002937	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
179408002938	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
179408002939	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408002940	dimer interface [polypeptide binding]; other site
179408002941	conserved gate region; other site
179408002942	putative PBP binding loops; other site
179408002943	ABC-ATPase subunit interface; other site
179408002944	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
179408002945	Domain of unknown function DUF20; Region: UPF0118; pfam01594
179408002946	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408002947	Probable transposase; Region: OrfB_IS605; pfam01385
179408002948	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408002949	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
179408002950	HlyD family secretion protein; Region: HlyD_3; pfam13437
179408002951	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
179408002952	Sec8 exocyst complex component specific domain; Region: Sec8_exocyst; pfam04048
179408002953	PAS domain; Region: PAS_10; pfam13596
179408002954	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
179408002955	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408002956	dimer interface [polypeptide binding]; other site
179408002957	phosphorylation site [posttranslational modification]
179408002958	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408002959	ATP binding site [chemical binding]; other site
179408002960	Mg2+ binding site [ion binding]; other site
179408002961	G-X-G motif; other site
179408002962	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
179408002963	DDE superfamily endonuclease; Region: DDE_3; pfam13358
179408002964	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
179408002965	CheB methylesterase; Region: CheB_methylest; pfam01339
179408002966	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
179408002967	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
179408002968	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
179408002969	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
179408002970	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
179408002971	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408002972	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
179408002973	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
179408002974	active site residue [active]
179408002975	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
179408002976	GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060
179408002977	putative GSH binding site (G-site) [chemical binding]; other site
179408002978	active site cysteine [active]
179408002979	putative C-terminal domain interface [polypeptide binding]; other site
179408002980	putative dimer interface [polypeptide binding]; other site
179408002981	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
179408002982	putative N-terminal domain interface [polypeptide binding]; other site
179408002983	putative dimer interface [polypeptide binding]; other site
179408002984	putative substrate binding pocket (H-site) [chemical binding]; other site
179408002985	DEAD-like helicases superfamily; Region: DEXDc; smart00487
179408002986	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
179408002987	ATP binding site [chemical binding]; other site
179408002988	putative Mg++ binding site [ion binding]; other site
179408002989	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
179408002990	nucleotide binding region [chemical binding]; other site
179408002991	ATP-binding site [chemical binding]; other site
179408002992	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
179408002993	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408002994	active site
179408002995	phosphorylation site [posttranslational modification]
179408002996	intermolecular recognition site; other site
179408002997	dimerization interface [polypeptide binding]; other site
179408002998	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
179408002999	DNA binding site [nucleotide binding]
179408003000	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
179408003001	putative binding surface; other site
179408003002	active site
179408003003	Response regulator receiver domain; Region: Response_reg; pfam00072
179408003004	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408003005	active site
179408003006	phosphorylation site [posttranslational modification]
179408003007	intermolecular recognition site; other site
179408003008	dimerization interface [polypeptide binding]; other site
179408003009	Response regulator receiver domain; Region: Response_reg; pfam00072
179408003010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408003011	active site
179408003012	phosphorylation site [posttranslational modification]
179408003013	intermolecular recognition site; other site
179408003014	dimerization interface [polypeptide binding]; other site
179408003015	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408003016	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408003017	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003018	PAS domain; Region: PAS_9; pfam13426
179408003019	putative active site [active]
179408003020	heme pocket [chemical binding]; other site
179408003021	PAS domain; Region: PAS_9; pfam13426
179408003022	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003023	PAS domain; Region: PAS_9; pfam13426
179408003024	putative active site [active]
179408003025	heme pocket [chemical binding]; other site
179408003026	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408003027	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408003028	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003029	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
179408003030	putative active site [active]
179408003031	heme pocket [chemical binding]; other site
179408003032	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408003033	dimer interface [polypeptide binding]; other site
179408003034	phosphorylation site [posttranslational modification]
179408003035	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408003036	ATP binding site [chemical binding]; other site
179408003037	Mg2+ binding site [ion binding]; other site
179408003038	G-X-G motif; other site
179408003039	Response regulator receiver domain; Region: Response_reg; pfam00072
179408003040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408003041	active site
179408003042	phosphorylation site [posttranslational modification]
179408003043	intermolecular recognition site; other site
179408003044	dimerization interface [polypeptide binding]; other site
179408003045	Response regulator receiver domain; Region: Response_reg; pfam00072
179408003046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408003047	active site
179408003048	phosphorylation site [posttranslational modification]
179408003049	intermolecular recognition site; other site
179408003050	dimerization interface [polypeptide binding]; other site
179408003051	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
179408003052	active site
179408003053	phosphorylation site [posttranslational modification]
179408003054	intermolecular recognition site; other site
179408003055	dimerization interface [polypeptide binding]; other site
179408003056	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408003057	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408003058	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408003059	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408003060	putative active site [active]
179408003061	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408003062	putative active site [active]
179408003063	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408003064	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408003065	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408003066	binding surface
179408003067	TPR motif; other site
179408003068	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408003069	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408003070	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408003071	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408003072	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408003073	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408003074	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
179408003075	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
179408003076	GatB domain; Region: GatB_Yqey; smart00845
179408003077	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003078	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408003079	putative active site [active]
179408003080	heme pocket [chemical binding]; other site
179408003081	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003082	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408003083	putative active site [active]
179408003084	heme pocket [chemical binding]; other site
179408003085	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003086	putative active site [active]
179408003087	heme pocket [chemical binding]; other site
179408003088	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003089	PAS fold; Region: PAS_3; pfam08447
179408003090	putative active site [active]
179408003091	heme pocket [chemical binding]; other site
179408003092	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003093	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408003094	putative active site [active]
179408003095	heme pocket [chemical binding]; other site
179408003096	PAS domain; Region: PAS; smart00091
179408003097	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
179408003098	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408003099	dimer interface [polypeptide binding]; other site
179408003100	phosphorylation site [posttranslational modification]
179408003101	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408003102	ATP binding site [chemical binding]; other site
179408003103	Mg2+ binding site [ion binding]; other site
179408003104	G-X-G motif; other site
179408003105	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408003106	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408003107	active site
179408003108	phosphorylation site [posttranslational modification]
179408003109	intermolecular recognition site; other site
179408003110	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408003111	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408003112	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003113	PAS fold; Region: PAS_3; pfam08447
179408003114	putative active site [active]
179408003115	heme pocket [chemical binding]; other site
179408003116	PAS domain S-box; Region: sensory_box; TIGR00229
179408003117	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003118	putative active site [active]
179408003119	heme pocket [chemical binding]; other site
179408003120	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408003121	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408003122	metal binding site [ion binding]; metal-binding site
179408003123	active site
179408003124	I-site; other site
179408003125	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
179408003126	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408003127	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408003128	Probable transposase; Region: OrfB_IS605; pfam01385
179408003129	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408003130	Uncharacterized conserved protein [Function unknown]; Region: COG1543
179408003131	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
179408003132	active site
179408003133	substrate binding site [chemical binding]; other site
179408003134	catalytic site [active]
179408003135	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
179408003136	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408003137	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408003138	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
179408003139	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408003140	putative active site [active]
179408003141	putative NTP binding site [chemical binding]; other site
179408003142	putative nucleic acid binding site [nucleotide binding]; other site
179408003143	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408003144	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408003145	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408003146	active site
179408003147	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
179408003148	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
179408003149	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
179408003150	active site
179408003151	catalytic tetrad [active]
179408003152	GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450
179408003153	GIY-YIG motif/motif A; other site
179408003154	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
179408003155	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
179408003156	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
179408003157	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
179408003158	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
179408003159	DNA methylase; Region: N6_N4_Mtase; pfam01555
179408003160	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408003161	non-specific DNA binding site [nucleotide binding]; other site
179408003162	salt bridge; other site
179408003163	sequence-specific DNA binding site [nucleotide binding]; other site
179408003164	Restriction endonuclease PvuII; Region: Endonuc-PvuII; pfam09225
179408003165	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
179408003166	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
179408003167	HIGH motif; other site
179408003168	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
179408003169	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
179408003170	active site
179408003171	KMSKS motif; other site
179408003172	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
179408003173	tRNA binding surface [nucleotide binding]; other site
179408003174	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408003175	putative active site [active]
179408003176	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
179408003177	ribosomal protein S14; Region: rps14; CHL00074
179408003178	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
179408003179	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
179408003180	minor groove reading motif; other site
179408003181	helix-hairpin-helix signature motif; other site
179408003182	substrate binding pocket [chemical binding]; other site
179408003183	active site
179408003184	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
179408003185	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
179408003186	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
179408003187	active site
179408003188	putative substrate binding region [chemical binding]; other site
179408003189	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
179408003190	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
179408003191	putative substrate binding region [chemical binding]; other site
179408003192	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
179408003193	active site
179408003194	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
179408003195	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
179408003196	putative substrate translocation pore; other site
179408003197	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
179408003198	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
179408003199	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
179408003200	FOG: CBS domain [General function prediction only]; Region: COG0517
179408003201	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
179408003202	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408003203	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408003204	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408003205	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408003206	dimer interface [polypeptide binding]; other site
179408003207	phosphorylation site [posttranslational modification]
179408003208	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408003209	ATP binding site [chemical binding]; other site
179408003210	Mg2+ binding site [ion binding]; other site
179408003211	G-X-G motif; other site
179408003212	HEAT repeats; Region: HEAT_2; pfam13646
179408003213	HEAT repeats; Region: HEAT_2; pfam13646
179408003214	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
179408003215	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
179408003216	dimerization interface [polypeptide binding]; other site
179408003217	putative DNA binding site [nucleotide binding]; other site
179408003218	putative Zn2+ binding site [ion binding]; other site
179408003219	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
179408003220	amphipathic channel; other site
179408003221	Asn-Pro-Ala signature motifs; other site
179408003222	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
179408003223	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
179408003224	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
179408003225	arsenical-resistance protein; Region: acr3; TIGR00832
179408003226	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
179408003227	Low molecular weight phosphatase family; Region: LMWPc; cd00115
179408003228	active site
179408003229	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
179408003230	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408003231	FeS/SAM binding site; other site
179408003232	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
179408003233	Uncharacterized conserved protein [Function unknown]; Region: COG0398
179408003234	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
179408003235	Cache domain; Region: Cache_1; pfam02743
179408003236	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408003237	GAF domain; Region: GAF; pfam01590
179408003238	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408003239	dimer interface [polypeptide binding]; other site
179408003240	phosphorylation site [posttranslational modification]
179408003241	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408003242	ATP binding site [chemical binding]; other site
179408003243	Mg2+ binding site [ion binding]; other site
179408003244	G-X-G motif; other site
179408003245	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408003246	S-adenosylmethionine binding site [chemical binding]; other site
179408003247	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
179408003248	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
179408003249	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
179408003250	motif II; other site
179408003251	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
179408003252	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
179408003253	putative ligand binding site [chemical binding]; other site
179408003254	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
179408003255	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
179408003256	TM-ABC transporter signature motif; other site
179408003257	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
179408003258	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
179408003259	TM-ABC transporter signature motif; other site
179408003260	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
179408003261	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
179408003262	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
179408003263	Walker A/P-loop; other site
179408003264	ATP binding site [chemical binding]; other site
179408003265	Q-loop/lid; other site
179408003266	ABC transporter signature motif; other site
179408003267	Walker B; other site
179408003268	D-loop; other site
179408003269	H-loop/switch region; other site
179408003270	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
179408003271	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
179408003272	Walker A/P-loop; other site
179408003273	ATP binding site [chemical binding]; other site
179408003274	Q-loop/lid; other site
179408003275	ABC transporter signature motif; other site
179408003276	Walker B; other site
179408003277	D-loop; other site
179408003278	H-loop/switch region; other site
179408003279	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408003280	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408003281	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408003282	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408003283	CheW-like domain; Region: CheW; pfam01584
179408003284	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
179408003285	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
179408003286	putative binding surface; other site
179408003287	active site
179408003288	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
179408003289	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408003290	ATP binding site [chemical binding]; other site
179408003291	Mg2+ binding site [ion binding]; other site
179408003292	G-X-G motif; other site
179408003293	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
179408003294	Response regulator receiver domain; Region: Response_reg; pfam00072
179408003295	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408003296	active site
179408003297	phosphorylation site [posttranslational modification]
179408003298	intermolecular recognition site; other site
179408003299	dimerization interface [polypeptide binding]; other site
179408003300	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408003301	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003302	putative active site [active]
179408003303	heme pocket [chemical binding]; other site
179408003304	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003305	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408003306	putative active site [active]
179408003307	heme pocket [chemical binding]; other site
179408003308	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408003309	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003310	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408003311	putative active site [active]
179408003312	heme pocket [chemical binding]; other site
179408003313	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003314	putative active site [active]
179408003315	heme pocket [chemical binding]; other site
179408003316	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408003317	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003318	putative active site [active]
179408003319	heme pocket [chemical binding]; other site
179408003320	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003321	putative active site [active]
179408003322	heme pocket [chemical binding]; other site
179408003323	PAS domain S-box; Region: sensory_box; TIGR00229
179408003324	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003325	putative active site [active]
179408003326	heme pocket [chemical binding]; other site
179408003327	PAS domain; Region: PAS_9; pfam13426
179408003328	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003329	PAS domain; Region: PAS_9; pfam13426
179408003330	putative active site [active]
179408003331	heme pocket [chemical binding]; other site
179408003332	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
179408003333	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
179408003334	dimer interface [polypeptide binding]; other site
179408003335	putative CheW interface [polypeptide binding]; other site
179408003336	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
179408003337	Response regulator receiver domain; Region: Response_reg; pfam00072
179408003338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408003339	active site
179408003340	phosphorylation site [posttranslational modification]
179408003341	intermolecular recognition site; other site
179408003342	dimerization interface [polypeptide binding]; other site
179408003343	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
179408003344	Active Sites [active]
179408003345	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
179408003346	intersubunit interface [polypeptide binding]; other site
179408003347	active site
179408003348	zinc binding site [ion binding]; other site
179408003349	Na+ binding site [ion binding]; other site
179408003350	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408003351	putative active site [active]
179408003352	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
179408003353	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
179408003354	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
179408003355	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
179408003356	RNA binding site [nucleotide binding]; other site
179408003357	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408003358	putative active site [active]
179408003359	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
179408003360	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
179408003361	putative active site [active]
179408003362	coproporphyrinogen III oxidase; Provisional; Region: PRK07379
179408003363	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408003364	FeS/SAM binding site; other site
179408003365	HemN C-terminal domain; Region: HemN_C; pfam06969
179408003366	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
179408003367	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
179408003368	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
179408003369	putative lipid kinase; Reviewed; Region: PRK13057
179408003370	HEAT repeats; Region: HEAT_2; pfam13646
179408003371	HEAT repeats; Region: HEAT_2; pfam13646
179408003372	HEAT repeats; Region: HEAT_2; pfam13646
179408003373	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
179408003374	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
179408003375	inhibitor-cofactor binding pocket; inhibition site
179408003376	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408003377	catalytic residue [active]
179408003378	Bacterial sugar transferase; Region: Bac_transf; pfam02397
179408003379	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
179408003380	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
179408003381	NAD(P) binding site [chemical binding]; other site
179408003382	active site
179408003383	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
179408003384	putative ADP-binding pocket [chemical binding]; other site
179408003385	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408003386	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408003387	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
179408003388	putative ADP-binding pocket [chemical binding]; other site
179408003389	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408003390	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
179408003391	putative ADP-binding pocket [chemical binding]; other site
179408003392	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
179408003393	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
179408003394	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
179408003395	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
179408003396	NAD(P) binding site [chemical binding]; other site
179408003397	homodimer interface [polypeptide binding]; other site
179408003398	substrate binding site [chemical binding]; other site
179408003399	active site
179408003400	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
179408003401	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
179408003402	Chain length determinant protein; Region: Wzz; cl15801
179408003403	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
179408003404	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
179408003405	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
179408003406	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408003407	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003408	putative active site [active]
179408003409	heme pocket [chemical binding]; other site
179408003410	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003411	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408003412	putative active site [active]
179408003413	heme pocket [chemical binding]; other site
179408003414	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408003415	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003416	putative active site [active]
179408003417	heme pocket [chemical binding]; other site
179408003418	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408003419	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408003420	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408003421	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408003422	dimer interface [polypeptide binding]; other site
179408003423	phosphorylation site [posttranslational modification]
179408003424	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408003425	ATP binding site [chemical binding]; other site
179408003426	Mg2+ binding site [ion binding]; other site
179408003427	G-X-G motif; other site
179408003428	Transcriptional regulator [Transcription]; Region: LysR; COG0583
179408003429	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
179408003430	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
179408003431	dimerization interface [polypeptide binding]; other site
179408003432	hypothetical protein; Provisional; Region: PRK07394
179408003433	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
179408003434	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
179408003435	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
179408003436	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
179408003437	GTP binding site; other site
179408003438	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
179408003439	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
179408003440	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
179408003441	catalytic residue [active]
179408003442	Transcriptional regulator [Transcription]; Region: LytR; COG1316
179408003443	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
179408003444	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408003445	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408003446	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408003447	S-layer homology domain; Region: SLH; pfam00395
179408003448	S-layer homology domain; Region: SLH; pfam00395
179408003449	S-layer homology domain; Region: SLH; pfam00395
179408003450	Protein of unknown function DUF262; Region: DUF262; pfam03235
179408003451	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408003452	active site
179408003453	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
179408003454	active site
179408003455	catalytic triad [active]
179408003456	oxyanion hole [active]
179408003457	DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191
179408003458	Domain of unknown function (DUF1818); Region: DUF1818; pfam08848
179408003459	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
179408003460	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
179408003461	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
179408003462	Subunit I/III interface [polypeptide binding]; other site
179408003463	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
179408003464	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
179408003465	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
179408003466	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
179408003467	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
179408003468	Predicted membrane protein [Function unknown]; Region: COG4244
179408003469	Predicted membrane protein [Function unknown]; Region: COG4244
179408003470	glucose-1-dehydrogenase; Provisional; Region: PRK08936
179408003471	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
179408003472	NAD binding site [chemical binding]; other site
179408003473	homodimer interface [polypeptide binding]; other site
179408003474	active site
179408003475	alpha-glucosidase; Provisional; Region: PRK10137
179408003476	Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200
179408003477	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
179408003478	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
179408003479	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
179408003480	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
179408003481	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
179408003482	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
179408003483	active site
179408003484	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
179408003485	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
179408003486	active site
179408003487	metal binding site [ion binding]; metal-binding site
179408003488	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
179408003489	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
179408003490	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
179408003491	preprotein translocase subunit SecY; Validated; Region: secY; CHL00161
179408003492	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408003493	Probable transposase; Region: OrfB_IS605; pfam01385
179408003494	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408003495	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
179408003496	Strictosidine synthase; Region: Str_synth; pfam03088
179408003497	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
179408003498	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
179408003499	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
179408003500	active site
179408003501	dimer interface [polypeptide binding]; other site
179408003502	metal binding site [ion binding]; metal-binding site
179408003503	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408003504	TPR motif; other site
179408003505	binding surface
179408003506	TPR repeat; Region: TPR_11; pfam13414
179408003507	TPR repeat; Region: TPR_11; pfam13414
179408003508	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
179408003509	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
179408003510	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
179408003511	dihydropteroate synthase; Region: DHPS; TIGR01496
179408003512	substrate binding pocket [chemical binding]; other site
179408003513	dimer interface [polypeptide binding]; other site
179408003514	inhibitor binding site; inhibition site
179408003515	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408003516	putative active site [active]
179408003517	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
179408003518	triosephosphate isomerase; Provisional; Region: PRK14565
179408003519	substrate binding site [chemical binding]; other site
179408003520	dimer interface [polypeptide binding]; other site
179408003521	catalytic triad [active]
179408003522	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
179408003523	Response regulator receiver domain; Region: Response_reg; pfam00072
179408003524	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408003525	active site
179408003526	phosphorylation site [posttranslational modification]
179408003527	intermolecular recognition site; other site
179408003528	dimerization interface [polypeptide binding]; other site
179408003529	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408003530	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408003531	metal binding site [ion binding]; metal-binding site
179408003532	active site
179408003533	I-site; other site
179408003534	Hemerythrin; Region: Hemerythrin; cd12107
179408003535	Fe binding site [ion binding]; other site
179408003536	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
179408003537	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408003538	GAF domain; Region: GAF_3; pfam13492
179408003539	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003540	PAS fold; Region: PAS_3; pfam08447
179408003541	putative active site [active]
179408003542	heme pocket [chemical binding]; other site
179408003543	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408003544	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003545	putative active site [active]
179408003546	heme pocket [chemical binding]; other site
179408003547	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408003548	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408003549	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408003550	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408003551	dimer interface [polypeptide binding]; other site
179408003552	phosphorylation site [posttranslational modification]
179408003553	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408003554	ATP binding site [chemical binding]; other site
179408003555	Mg2+ binding site [ion binding]; other site
179408003556	G-X-G motif; other site
179408003557	Response regulator receiver domain; Region: Response_reg; pfam00072
179408003558	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408003559	active site
179408003560	phosphorylation site [posttranslational modification]
179408003561	intermolecular recognition site; other site
179408003562	dimerization interface [polypeptide binding]; other site
179408003563	Response regulator receiver domain; Region: Response_reg; pfam00072
179408003564	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408003565	active site
179408003566	phosphorylation site [posttranslational modification]
179408003567	intermolecular recognition site; other site
179408003568	dimerization interface [polypeptide binding]; other site
179408003569	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
179408003570	putative binding surface; other site
179408003571	active site
179408003572	gpW; Region: gpW; pfam02831
179408003573	Transposase; Region: HTH_Tnp_IS630; pfam01710
179408003574	Helix-turn-helix domain; Region: HTH_28; pfam13518
179408003575	DDE superfamily endonuclease; Region: DDE_3; pfam13358
179408003576	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408003577	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408003578	GAF domain; Region: GAF; cl17456
179408003579	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408003580	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408003581	GAF domain; Region: GAF; pfam01590
179408003582	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408003583	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408003584	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408003585	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408003586	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408003587	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408003588	ATP binding site [chemical binding]; other site
179408003589	Mg2+ binding site [ion binding]; other site
179408003590	G-X-G motif; other site
179408003591	photosystem II 44 kDa protein; Region: psbC; CHL00035
179408003592	photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153
179408003593	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
179408003594	D1 interface; other site
179408003595	chlorophyll binding site; other site
179408003596	pheophytin binding site; other site
179408003597	beta carotene binding site; other site
179408003598	cytochrome b559 beta interface; other site
179408003599	quinone binding site; other site
179408003600	cytochrome b559 alpha interface; other site
179408003601	protein J interface; other site
179408003602	protein H interface; other site
179408003603	protein X interface; other site
179408003604	core light harvesting protein interface; other site
179408003605	protein L interface; other site
179408003606	CP43 interface; other site
179408003607	protein T interface; other site
179408003608	Fe binding site [ion binding]; other site
179408003609	protein M interface; other site
179408003610	Mn-stabilizing polypeptide interface; other site
179408003611	bromide binding site; other site
179408003612	cytochrome c-550 interface; other site
179408003613	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
179408003614	Probable transposase; Region: OrfB_IS605; pfam01385
179408003615	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408003616	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
179408003617	photosystem I assembly protein Ycf4; Provisional; Region: PRK02542
179408003618	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
179408003619	active site
179408003620	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
179408003621	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952
179408003622	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
179408003623	dimer interface [polypeptide binding]; other site
179408003624	active site
179408003625	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408003626	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408003627	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
179408003628	putative active site [active]
179408003629	putative NTP binding site [chemical binding]; other site
179408003630	putative nucleic acid binding site [nucleotide binding]; other site
179408003631	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408003632	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408003633	active site
179408003634	Probable transposase; Region: OrfB_IS605; pfam01385
179408003635	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408003636	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
179408003637	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
179408003638	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
179408003639	ligand binding site [chemical binding]; other site
179408003640	flexible hinge region; other site
179408003641	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408003642	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408003643	dimer interface [polypeptide binding]; other site
179408003644	phosphorylation site [posttranslational modification]
179408003645	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408003646	ATP binding site [chemical binding]; other site
179408003647	Mg2+ binding site [ion binding]; other site
179408003648	G-X-G motif; other site
179408003649	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
179408003650	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408003651	ATP binding site [chemical binding]; other site
179408003652	Mg2+ binding site [ion binding]; other site
179408003653	G-X-G motif; other site
179408003654	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
179408003655	ATP binding site [chemical binding]; other site
179408003656	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
179408003657	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
179408003658	Tetratricopeptide repeat; Region: TPR_9; pfam13371
179408003659	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
179408003660	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
179408003661	hydrophobic ligand binding site; other site
179408003662	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408003663	Probable transposase; Region: OrfB_IS605; pfam01385
179408003664	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408003665	Conserved TM helix; Region: TM_helix; pfam05552
179408003666	Conserved TM helix; Region: TM_helix; pfam05552
179408003667	Conserved TM helix; Region: TM_helix; pfam05552
179408003668	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408003669	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408003670	active site
179408003671	ATP binding site [chemical binding]; other site
179408003672	substrate binding site [chemical binding]; other site
179408003673	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
179408003674	substrate binding site [chemical binding]; other site
179408003675	activation loop (A-loop); other site
179408003676	activation loop (A-loop); other site
179408003677	AAA ATPase domain; Region: AAA_16; pfam13191
179408003678	Predicted ATPase [General function prediction only]; Region: COG3899
179408003679	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408003680	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408003681	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
179408003682	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408003683	ATP binding site [chemical binding]; other site
179408003684	Mg2+ binding site [ion binding]; other site
179408003685	G-X-G motif; other site
179408003686	KTSC domain; Region: KTSC; pfam13619
179408003687	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
179408003688	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
179408003689	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
179408003690	NAD binding site [chemical binding]; other site
179408003691	substrate binding site [chemical binding]; other site
179408003692	active site
179408003693	Domain of unknown function (DUF4291); Region: DUF4291; pfam14124
179408003694	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408003695	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
179408003696	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408003697	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408003698	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408003699	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408003700	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003701	putative active site [active]
179408003702	heme pocket [chemical binding]; other site
179408003703	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
179408003704	cyclase homology domain; Region: CHD; cd07302
179408003705	nucleotidyl binding site; other site
179408003706	metal binding site [ion binding]; metal-binding site
179408003707	dimer interface [polypeptide binding]; other site
179408003708	Response regulator receiver domain; Region: Response_reg; pfam00072
179408003709	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408003710	active site
179408003711	phosphorylation site [posttranslational modification]
179408003712	intermolecular recognition site; other site
179408003713	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408003714	dimerization interface [polypeptide binding]; other site
179408003715	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408003716	dimer interface [polypeptide binding]; other site
179408003717	phosphorylation site [posttranslational modification]
179408003718	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408003719	ATP binding site [chemical binding]; other site
179408003720	Mg2+ binding site [ion binding]; other site
179408003721	G-X-G motif; other site
179408003722	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
179408003723	GUN4-like; Region: GUN4; pfam05419
179408003724	Uncharacterized conserved protein [Function unknown]; Region: COG1434
179408003725	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
179408003726	putative active site [active]
179408003727	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408003728	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
179408003729	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
179408003730	putative acyl-acceptor binding pocket; other site
179408003731	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
179408003732	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
179408003733	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
179408003734	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
179408003735	dimer interface [polypeptide binding]; other site
179408003736	active site
179408003737	CoA binding pocket [chemical binding]; other site
179408003738	putative phosphate acyltransferase; Provisional; Region: PRK05331
179408003739	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
179408003740	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
179408003741	ribosomal protein S16; Region: rps16; CHL00005
179408003742	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
179408003743	KH domain; Region: KH_4; pfam13083
179408003744	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
179408003745	PhoH-like protein; Region: PhoH; pfam02562
179408003746	Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509
179408003747	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
179408003748	protein I interface; other site
179408003749	D2 interface; other site
179408003750	protein T interface; other site
179408003751	chlorophyll binding site; other site
179408003752	beta carotene binding site; other site
179408003753	pheophytin binding site; other site
179408003754	manganese-stabilizing polypeptide interface; other site
179408003755	CP43 interface; other site
179408003756	protein L interface; other site
179408003757	oxygen evolving complex binding site; other site
179408003758	bromide binding site; other site
179408003759	quinone binding site; other site
179408003760	Fe binding site [ion binding]; other site
179408003761	core light harvesting interface; other site
179408003762	cytochrome b559 alpha subunit interface; other site
179408003763	cytochrome c-550 interface; other site
179408003764	protein J interface; other site
179408003765	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
179408003766	putative active site [active]
179408003767	Sporulation and spore germination; Region: Germane; pfam10646
179408003768	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
179408003769	dimerization interface [polypeptide binding]; other site
179408003770	putative DNA binding site [nucleotide binding]; other site
179408003771	putative Zn2+ binding site [ion binding]; other site
179408003772	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
179408003773	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
179408003774	carboxyltransferase (CT) interaction site; other site
179408003775	biotinylation site [posttranslational modification]; other site
179408003776	elongation factor P; Validated; Region: PRK00529
179408003777	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
179408003778	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
179408003779	RNA binding site [nucleotide binding]; other site
179408003780	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
179408003781	RNA binding site [nucleotide binding]; other site
179408003782	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
179408003783	active site
179408003784	thiamine monophosphate kinase; Provisional; Region: PRK05731
179408003785	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
179408003786	ATP binding site [chemical binding]; other site
179408003787	dimerization interface [polypeptide binding]; other site
179408003788	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
179408003789	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
179408003790	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
179408003791	catalytic residue [active]
179408003792	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
179408003793	PLD-like domain; Region: PLDc_2; pfam13091
179408003794	putative active site [active]
179408003795	catalytic site [active]
179408003796	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
179408003797	PLD-like domain; Region: PLDc_2; pfam13091
179408003798	putative active site [active]
179408003799	catalytic site [active]
179408003800	Helix-hairpin-helix motif; Region: HHH; pfam00633
179408003801	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
179408003802	calcium/proton exchanger (cax); Region: cax; TIGR00378
179408003803	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
179408003804	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408003805	putative active site [active]
179408003806	MORN repeat; Region: MORN; cl14787
179408003807	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
179408003808	MORN repeat; Region: MORN; cl14787
179408003809	MORN repeat; Region: MORN; pfam02493
179408003810	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
179408003811	Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; Region: MORN; smart00698
179408003812	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408003813	Probable transposase; Region: OrfB_IS605; pfam01385
179408003814	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408003815	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
179408003816	catalytic motif [active]
179408003817	Catalytic residue [active]
179408003818	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
179408003819	phosphoglyceromutase; Provisional; Region: PRK05434
179408003820	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
179408003821	Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279
179408003822	active site
179408003823	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
179408003824	nudix motif; other site
179408003825	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
179408003826	active site residue [active]
179408003827	Mannitol repressor; Region: MtlR; cl11450
179408003828	Domain of unknown function (DUF1802); Region: DUF1802; cl01755
179408003829	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408003830	putative active site [active]
179408003831	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408003832	putative active site [active]
179408003833	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
179408003834	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003835	PAS domain; Region: PAS_9; pfam13426
179408003836	putative active site [active]
179408003837	heme pocket [chemical binding]; other site
179408003838	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408003839	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
179408003840	PAS domain S-box; Region: sensory_box; TIGR00229
179408003841	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408003842	putative active site [active]
179408003843	heme pocket [chemical binding]; other site
179408003844	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408003845	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408003846	metal binding site [ion binding]; metal-binding site
179408003847	active site
179408003848	I-site; other site
179408003849	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
179408003850	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
179408003851	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
179408003852	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408003853	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408003854	Probable transposase; Region: OrfB_IS605; pfam01385
179408003855	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408003856	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
179408003857	Active_site [active]
179408003858	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
179408003859	phosphopeptide binding site; other site
179408003860	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
179408003861	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
179408003862	phosphopeptide binding site; other site
179408003863	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
179408003864	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
179408003865	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
179408003866	cofactor binding site; other site
179408003867	DNA binding site [nucleotide binding]
179408003868	substrate interaction site [chemical binding]; other site
179408003869	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333
179408003870	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
179408003871	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408003872	FeS/SAM binding site; other site
179408003873	TRAM domain; Region: TRAM; pfam01938
179408003874	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
179408003875	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
179408003876	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
179408003877	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
179408003878	Domain of unknown function DUF20; Region: UPF0118; pfam01594
179408003879	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
179408003880	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
179408003881	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
179408003882	protein binding site [polypeptide binding]; other site
179408003883	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
179408003884	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
179408003885	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408003886	Radical SAM superfamily; Region: Radical_SAM; pfam04055
179408003887	FeS/SAM binding site; other site
179408003888	Fatty acid desaturase; Region: FA_desaturase; pfam00487
179408003889	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
179408003890	Di-iron ligands [ion binding]; other site
179408003891	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
179408003892	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
179408003893	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
179408003894	iron-sulfur cluster [ion binding]; other site
179408003895	[2Fe-2S] cluster binding site [ion binding]; other site
179408003896	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
179408003897	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
179408003898	Transposase IS200 like; Region: Y1_Tnp; pfam01797
179408003899	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408003900	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408003901	Probable transposase; Region: OrfB_IS605; pfam01385
179408003902	hybrid cluster protein; Provisional; Region: PRK05290
179408003903	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
179408003904	ACS interaction site; other site
179408003905	CODH interaction site; other site
179408003906	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
179408003907	hybrid metal cluster; other site
179408003908	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
179408003909	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408003910	FeS/SAM binding site; other site
179408003911	HemN C-terminal domain; Region: HemN_C; pfam06969
179408003912	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
179408003913	heme binding pocket [chemical binding]; other site
179408003914	heme ligand [chemical binding]; other site
179408003915	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
179408003916	diiron binding motif [ion binding]; other site
179408003917	Predicted transcriptional regulators [Transcription]; Region: COG1733
179408003918	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
179408003919	dimerization interface [polypeptide binding]; other site
179408003920	putative DNA binding site [nucleotide binding]; other site
179408003921	putative Zn2+ binding site [ion binding]; other site
179408003922	Transposase IS200 like; Region: Y1_Tnp; pfam01797
179408003923	Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891
179408003924	glycine dehydrogenase; Provisional; Region: PRK05367
179408003925	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
179408003926	tetramer interface [polypeptide binding]; other site
179408003927	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408003928	catalytic residue [active]
179408003929	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
179408003930	tetramer interface [polypeptide binding]; other site
179408003931	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408003932	catalytic residue [active]
179408003933	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
179408003934	lipoyl attachment site [posttranslational modification]; other site
179408003935	D-aminoacyl-tRNA deacylase; Region: tRNA_deacylase; cl00716
179408003936	Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677
179408003937	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
179408003938	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
179408003939	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
179408003940	bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571
179408003941	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
179408003942	putative dimer interface [polypeptide binding]; other site
179408003943	[2Fe-2S] cluster binding site [ion binding]; other site
179408003944	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
179408003945	dimer interface [polypeptide binding]; other site
179408003946	[2Fe-2S] cluster binding site [ion binding]; other site
179408003947	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
179408003948	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
179408003949	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
179408003950	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
179408003951	catalytic loop [active]
179408003952	iron binding site [ion binding]; other site
179408003953	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
179408003954	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
179408003955	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
179408003956	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
179408003957	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
179408003958	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
179408003959	nickel binding site [ion binding]; other site
179408003960	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
179408003961	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
179408003962	hydrogenase accessory protein HypB; Region: hypB; TIGR00073
179408003963	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
179408003964	Acylphosphatase; Region: Acylphosphatase; pfam00708
179408003965	HypF finger; Region: zf-HYPF; pfam07503
179408003966	HypF finger; Region: zf-HYPF; pfam07503
179408003967	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
179408003968	HupF/HypC family; Region: HupF_HypC; pfam01455
179408003969	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
179408003970	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
179408003971	dimer interface [polypeptide binding]; other site
179408003972	PYR/PP interface [polypeptide binding]; other site
179408003973	TPP binding site [chemical binding]; other site
179408003974	substrate binding site [chemical binding]; other site
179408003975	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
179408003976	Domain of unknown function; Region: EKR; pfam10371
179408003977	4Fe-4S binding domain; Region: Fer4; pfam00037
179408003978	4Fe-4S binding domain; Region: Fer4; pfam00037
179408003979	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
179408003980	TPP-binding site [chemical binding]; other site
179408003981	dimer interface [polypeptide binding]; other site
179408003982	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
179408003983	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
179408003984	putative active site [active]
179408003985	putative FMN binding site [chemical binding]; other site
179408003986	putative substrate binding site [chemical binding]; other site
179408003987	Domain of unknown function (DUF305); Region: DUF305; pfam03713
179408003988	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
179408003989	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
179408003990	RRXRR protein; Region: RRXRR; pfam14239
179408003991	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408003992	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408003993	active site
179408003994	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
179408003995	dimerization interface [polypeptide binding]; other site
179408003996	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
179408003997	ATP binding site [chemical binding]; other site
179408003998	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
179408003999	active site
179408004000	catalytic residues [active]
179408004001	DNA binding site [nucleotide binding]
179408004002	Int/Topo IB signature motif; other site
179408004003	D5 N terminal like; Region: D5_N; smart00885
179408004004	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
179408004005	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408004006	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408004007	active site
179408004008	ATP binding site [chemical binding]; other site
179408004009	substrate binding site [chemical binding]; other site
179408004010	activation loop (A-loop); other site
179408004011	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408004012	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408004013	structural tetrad; other site
179408004014	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
179408004015	putative hydrophobic ligand binding site [chemical binding]; other site
179408004016	9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732
179408004017	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
179408004018	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487
179408004019	PemK-like protein; Region: PemK; pfam02452
179408004020	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
179408004021	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408004022	binding surface
179408004023	TPR motif; other site
179408004024	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
179408004025	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
179408004026	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
179408004027	putative NAD(P) binding site [chemical binding]; other site
179408004028	putative active site [active]
179408004029	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
179408004030	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
179408004031	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
179408004032	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
179408004033	putative dimer interface [polypeptide binding]; other site
179408004034	N-terminal domain interface [polypeptide binding]; other site
179408004035	putative substrate binding pocket (H-site) [chemical binding]; other site
179408004036	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408004037	S-adenosylmethionine binding site [chemical binding]; other site
179408004038	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
179408004039	Helix-turn-helix domain; Region: HTH_18; pfam12833
179408004040	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
179408004041	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
179408004042	DNA binding site [nucleotide binding]
179408004043	active site
179408004044	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
179408004045	MPT binding site; other site
179408004046	trimer interface [polypeptide binding]; other site
179408004047	photosystem II reaction center protein Psb28; Provisional; Region: PRK13612
179408004048	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
179408004049	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
179408004050	S-layer homology domain; Region: SLH; pfam00395
179408004051	S-layer homology domain; Region: SLH; pfam00395
179408004052	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408004053	putative active site [active]
179408004054	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
179408004055	Peptidase family M48; Region: Peptidase_M48; cl12018
179408004056	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
179408004057	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
179408004058	putative catalytic cysteine [active]
179408004059	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
179408004060	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408004061	active site
179408004062	ATP binding site [chemical binding]; other site
179408004063	substrate binding site [chemical binding]; other site
179408004064	activation loop (A-loop); other site
179408004065	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
179408004066	homooctamer interface [polypeptide binding]; other site
179408004067	active site
179408004068	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
179408004069	NADH dehydrogenase subunit 6; Region: ndhG; CHL00016
179408004070	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
179408004071	NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403
179408004072	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
179408004073	NADH dehydrogenase; Region: NADHdh; cl00469
179408004074	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
179408004075	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408004076	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408004077	active site
179408004078	ATP binding site [chemical binding]; other site
179408004079	substrate binding site [chemical binding]; other site
179408004080	activation loop (A-loop); other site
179408004081	Fic family protein [Function unknown]; Region: COG3177
179408004082	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
179408004083	Fic/DOC family; Region: Fic; pfam02661
179408004084	Pep3/Vps18/deep orange family; Region: Pep3_Vps18; pfam05131
179408004085	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
179408004086	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
179408004087	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
179408004088	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
179408004089	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
179408004090	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408004091	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408004092	Probable transposase; Region: OrfB_IS605; pfam01385
179408004093	Protein of unknown function (DUF565); Region: DUF565; pfam04483
179408004094	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
179408004095	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
179408004096	GAF domain; Region: GAF_3; pfam13492
179408004097	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408004098	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408004099	dimer interface [polypeptide binding]; other site
179408004100	phosphorylation site [posttranslational modification]
179408004101	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408004102	ATP binding site [chemical binding]; other site
179408004103	Mg2+ binding site [ion binding]; other site
179408004104	G-X-G motif; other site
179408004105	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
179408004106	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408004107	active site
179408004108	phosphorylation site [posttranslational modification]
179408004109	intermolecular recognition site; other site
179408004110	dimerization interface [polypeptide binding]; other site
179408004111	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
179408004112	DNA binding residues [nucleotide binding]
179408004113	dimerization interface [polypeptide binding]; other site
179408004114	1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296
179408004115	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
179408004116	glycogen binding site [chemical binding]; other site
179408004117	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350
179408004118	active site
179408004119	catalytic site [active]
179408004120	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
179408004121	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408004122	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408004123	Phytochrome region; Region: PHY; pfam00360
179408004124	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408004125	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408004126	metal binding site [ion binding]; metal-binding site
179408004127	active site
179408004128	I-site; other site
179408004129	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
179408004130	Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025
179408004131	Response regulator receiver domain; Region: Response_reg; pfam00072
179408004132	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408004133	active site
179408004134	phosphorylation site [posttranslational modification]
179408004135	intermolecular recognition site; other site
179408004136	dimerization interface [polypeptide binding]; other site
179408004137	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
179408004138	BON domain; Region: BON; cl02771
179408004139	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
179408004140	proposed catalytic triad [active]
179408004141	active site nucleophile [active]
179408004142	cyanophycin synthetase; Provisional; Region: PRK14016
179408004143	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
179408004144	CHASE domain; Region: CHASE; pfam03924
179408004145	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408004146	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408004147	dimer interface [polypeptide binding]; other site
179408004148	phosphorylation site [posttranslational modification]
179408004149	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408004150	ATP binding site [chemical binding]; other site
179408004151	Mg2+ binding site [ion binding]; other site
179408004152	G-X-G motif; other site
179408004153	putative hydrolase; Provisional; Region: PRK11460
179408004154	Predicted esterase [General function prediction only]; Region: COG0400
179408004155	Protein of unknown function (DUF2555); Region: DUF2555; pfam10742
179408004156	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
179408004157	Flavoprotein; Region: Flavoprotein; pfam02441
179408004158	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
179408004159	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
179408004160	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3657
179408004161	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
179408004162	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
179408004163	[2Fe-2S] cluster binding site [ion binding]; other site
179408004164	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
179408004165	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408004166	S-adenosylmethionine binding site [chemical binding]; other site
179408004167	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
179408004168	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
179408004169	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
179408004170	iron-sulfur cluster [ion binding]; other site
179408004171	[2Fe-2S] cluster binding site [ion binding]; other site
179408004172	Uncharacterized conserved protein [Function unknown]; Region: COG3349
179408004173	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
179408004174	capsid maturational protease; Provisional; Region: PHA03369
179408004175	S-layer homology domain; Region: SLH; pfam00395
179408004176	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
179408004177	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
179408004178	FIST N domain; Region: FIST; pfam08495
179408004179	FIST C domain; Region: FIST_C; pfam10442
179408004180	CP12 domain; Region: CP12; pfam02672
179408004181	Protein of unknown function (DUF3177); Region: DUF3177; pfam11375
179408004182	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408004183	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408004184	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
179408004185	Cache domain; Region: Cache_1; pfam02743
179408004186	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408004187	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408004188	dimerization interface [polypeptide binding]; other site
179408004189	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408004190	dimer interface [polypeptide binding]; other site
179408004191	phosphorylation site [posttranslational modification]
179408004192	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408004193	ATP binding site [chemical binding]; other site
179408004194	Mg2+ binding site [ion binding]; other site
179408004195	G-X-G motif; other site
179408004196	Response regulator receiver domain; Region: Response_reg; pfam00072
179408004197	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408004198	active site
179408004199	phosphorylation site [posttranslational modification]
179408004200	intermolecular recognition site; other site
179408004201	dimerization interface [polypeptide binding]; other site
179408004202	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
179408004203	cyclase homology domain; Region: CHD; cd07302
179408004204	nucleotidyl binding site; other site
179408004205	metal binding site [ion binding]; metal-binding site
179408004206	dimer interface [polypeptide binding]; other site
179408004207	Cache domain; Region: Cache_1; pfam02743
179408004208	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408004209	dimerization interface [polypeptide binding]; other site
179408004210	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408004211	dimer interface [polypeptide binding]; other site
179408004212	phosphorylation site [posttranslational modification]
179408004213	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408004214	ATP binding site [chemical binding]; other site
179408004215	Mg2+ binding site [ion binding]; other site
179408004216	G-X-G motif; other site
179408004217	Response regulator receiver domain; Region: Response_reg; pfam00072
179408004218	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408004219	active site
179408004220	phosphorylation site [posttranslational modification]
179408004221	intermolecular recognition site; other site
179408004222	dimerization interface [polypeptide binding]; other site
179408004223	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
179408004224	cyclase homology domain; Region: CHD; cd07302
179408004225	nucleotidyl binding site; other site
179408004226	metal binding site [ion binding]; metal-binding site
179408004227	dimer interface [polypeptide binding]; other site
179408004228	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
179408004229	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
179408004230	substrate binding pocket [chemical binding]; other site
179408004231	membrane-bound complex binding site; other site
179408004232	hinge residues; other site
179408004233	ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063
179408004234	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
179408004235	gamma subunit interface [polypeptide binding]; other site
179408004236	epsilon subunit interface [polypeptide binding]; other site
179408004237	LBP interface [polypeptide binding]; other site
179408004238	ATP synthase CF1 beta subunit; Region: atpB; CHL00060
179408004239	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
179408004240	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
179408004241	alpha subunit interaction interface [polypeptide binding]; other site
179408004242	Walker A motif; other site
179408004243	ATP binding site [chemical binding]; other site
179408004244	Walker B motif; other site
179408004245	inhibitor binding site; inhibition site
179408004246	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
179408004247	haemagglutination activity domain; Region: Haemagg_act; pfam05860
179408004248	flagellin; Validated; Region: PRK08026
179408004249	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
179408004250	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
179408004251	metal ion-dependent adhesion site (MIDAS); other site
179408004252	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
179408004253	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
179408004254	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
179408004255	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
179408004256	protein I interface; other site
179408004257	D2 interface; other site
179408004258	protein T interface; other site
179408004259	chlorophyll binding site; other site
179408004260	beta carotene binding site; other site
179408004261	pheophytin binding site; other site
179408004262	manganese-stabilizing polypeptide interface; other site
179408004263	CP43 interface; other site
179408004264	protein L interface; other site
179408004265	oxygen evolving complex binding site; other site
179408004266	bromide binding site; other site
179408004267	quinone binding site; other site
179408004268	Fe binding site [ion binding]; other site
179408004269	core light harvesting interface; other site
179408004270	cytochrome b559 alpha subunit interface; other site
179408004271	cytochrome c-550 interface; other site
179408004272	protein J interface; other site
179408004273	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
179408004274	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
179408004275	XisI protein; Region: XisI; pfam08869
179408004276	cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904
179408004277	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
179408004278	GUN4-like; Region: GUN4; pfam05419
179408004279	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
179408004280	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
179408004281	active site
179408004282	dimer interface [polypeptide binding]; other site
179408004283	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
179408004284	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
179408004285	active site
179408004286	FMN binding site [chemical binding]; other site
179408004287	substrate binding site [chemical binding]; other site
179408004288	3Fe-4S cluster binding site [ion binding]; other site
179408004289	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
179408004290	domain interface; other site
179408004291	Cupin domain; Region: Cupin_2; cl17218
179408004292	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
179408004293	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408004294	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408004295	active site
179408004296	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
179408004297	Response regulator receiver domain; Region: Response_reg; pfam00072
179408004298	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408004299	active site
179408004300	phosphorylation site [posttranslational modification]
179408004301	intermolecular recognition site; other site
179408004302	dimerization interface [polypeptide binding]; other site
179408004303	Haemolytic domain; Region: Haemolytic; pfam01809
179408004304	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755
179408004305	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
179408004306	RNA binding site [nucleotide binding]; other site
179408004307	active site
179408004308	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
179408004309	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408004310	allophanate hydrolase; Provisional; Region: PRK08186
179408004311	Amidase; Region: Amidase; cl11426
179408004312	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
179408004313	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
179408004314	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
179408004315	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408004316	dimer interface [polypeptide binding]; other site
179408004317	conserved gate region; other site
179408004318	putative PBP binding loops; other site
179408004319	ABC-ATPase subunit interface; other site
179408004320	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
179408004321	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
179408004322	Walker A/P-loop; other site
179408004323	ATP binding site [chemical binding]; other site
179408004324	Q-loop/lid; other site
179408004325	ABC transporter signature motif; other site
179408004326	Walker B; other site
179408004327	D-loop; other site
179408004328	H-loop/switch region; other site
179408004329	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
179408004330	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
179408004331	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
179408004332	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
179408004333	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
179408004334	active site
179408004335	iron coordination sites [ion binding]; other site
179408004336	substrate binding pocket [chemical binding]; other site
179408004337	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
179408004338	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
179408004339	HEAT repeats; Region: HEAT_2; pfam13646
179408004340	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
179408004341	CHAT domain; Region: CHAT; cl17868
179408004342	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
179408004343	CHASE2 domain; Region: CHASE2; pfam05226
179408004344	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
179408004345	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408004346	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
179408004347	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
179408004348	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
179408004349	Surface antigen; Region: Bac_surface_Ag; pfam01103
179408004350	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
179408004351	haemagglutination activity domain; Region: Haemagg_act; pfam05860
179408004352	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
179408004353	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408004354	S-adenosylmethionine binding site [chemical binding]; other site
179408004355	beta-lactamase TEM; Provisional; Region: PRK15442
179408004356	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
179408004357	urea carboxylase; Region: urea_carbox; TIGR02712
179408004358	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
179408004359	ATP-grasp domain; Region: ATP-grasp_4; cl17255
179408004360	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
179408004361	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
179408004362	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
179408004363	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
179408004364	carboxyltransferase (CT) interaction site; other site
179408004365	biotinylation site [posttranslational modification]; other site
179408004366	hypothetical protein; Provisional; Region: PRK06847
179408004367	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
179408004368	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
179408004369	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
179408004370	putative active site [active]
179408004371	putative dimer interface [polypeptide binding]; other site
179408004372	Staphylococcal nuclease homologues; Region: SNc; smart00318
179408004373	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
179408004374	Catalytic site; other site
179408004375	Protein of unknown function, DUF479; Region: DUF479; cl01203
179408004376	XisI protein; Region: XisI; pfam08869
179408004377	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408004378	putative active site [active]
179408004379	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
179408004380	catalytic motif [active]
179408004381	Catalytic residue [active]
179408004382	KWG Leptospira; Region: KWG; pfam07656
179408004383	acetyl-CoA synthetase; Provisional; Region: PRK00174
179408004384	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
179408004385	active site
179408004386	CoA binding site [chemical binding]; other site
179408004387	acyl-activating enzyme (AAE) consensus motif; other site
179408004388	AMP binding site [chemical binding]; other site
179408004389	acetate binding site [chemical binding]; other site
179408004390	Protein of unknown function (DUF433); Region: DUF433; cl01030
179408004391	ADP-glucose phosphorylase; Region: PLN02643
179408004392	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
179408004393	nucleotide binding site/active site [active]
179408004394	HIT family signature motif; other site
179408004395	catalytic residue [active]
179408004396	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
179408004397	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
179408004398	active site
179408004399	metal binding site [ion binding]; metal-binding site
179408004400	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
179408004401	Uncharacterized conserved protein [Function unknown]; Region: COG1479
179408004402	Protein of unknown function DUF262; Region: DUF262; pfam03235
179408004403	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
179408004404	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408004405	putative active site [active]
179408004406	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
179408004407	tartrate dehydrogenase; Region: TTC; TIGR02089
179408004408	bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500
179408004409	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
179408004410	active site
179408004411	dimer interface [polypeptide binding]; other site
179408004412	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
179408004413	active site
179408004414	Protein of unknown function, DUF547; Region: DUF547; pfam04784
179408004415	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408004416	putative active site [active]
179408004417	Predicted membrane protein (DUF2157); Region: DUF2157; cl10480
179408004418	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
179408004419	ferrochelatase; Reviewed; Region: hemH; PRK00035
179408004420	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
179408004421	active site
179408004422	C-terminal domain interface [polypeptide binding]; other site
179408004423	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
179408004424	active site
179408004425	N-terminal domain interface [polypeptide binding]; other site
179408004426	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; pfam00504
179408004427	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
179408004428	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
179408004429	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
179408004430	NAD(P) binding site [chemical binding]; other site
179408004431	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
179408004432	non-specific DNA binding site [nucleotide binding]; other site
179408004433	salt bridge; other site
179408004434	sequence-specific DNA binding site [nucleotide binding]; other site
179408004435	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408004436	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
179408004437	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408004438	putative active site [active]
179408004439	putative NTP binding site [chemical binding]; other site
179408004440	putative nucleic acid binding site [nucleotide binding]; other site
179408004441	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408004442	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408004443	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408004444	active site
179408004445	Domain of unknown function (DUF4394); Region: DUF4394; pfam14339
179408004446	Domain of unknown function (DUF4394); Region: DUF4394; pfam14339
179408004447	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
179408004448	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
179408004449	Walker A/P-loop; other site
179408004450	ATP binding site [chemical binding]; other site
179408004451	Q-loop/lid; other site
179408004452	ABC transporter signature motif; other site
179408004453	Walker B; other site
179408004454	D-loop; other site
179408004455	H-loop/switch region; other site
179408004456	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408004457	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
179408004458	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408004459	Substrate binding site [chemical binding]; other site
179408004460	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408004461	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408004462	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
179408004463	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408004464	dimer interface [polypeptide binding]; other site
179408004465	conserved gate region; other site
179408004466	putative PBP binding loops; other site
179408004467	ABC-ATPase subunit interface; other site
179408004468	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
179408004469	active site
179408004470	aspartate aminotransferase; Provisional; Region: PRK05764
179408004471	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
179408004472	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408004473	homodimer interface [polypeptide binding]; other site
179408004474	catalytic residue [active]
179408004475	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
179408004476	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
179408004477	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
179408004478	DNA binding residues [nucleotide binding]
179408004479	Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716
179408004480	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408004481	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408004482	Protein kinase domain; Region: Pkinase; pfam00069
179408004483	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408004484	active site
179408004485	ATP binding site [chemical binding]; other site
179408004486	substrate binding site [chemical binding]; other site
179408004487	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
179408004488	substrate binding site [chemical binding]; other site
179408004489	activation loop (A-loop); other site
179408004490	activation loop (A-loop); other site
179408004491	AAA ATPase domain; Region: AAA_16; pfam13191
179408004492	Predicted ATPase [General function prediction only]; Region: COG3899
179408004493	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408004494	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408004495	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408004496	ATP binding site [chemical binding]; other site
179408004497	Mg2+ binding site [ion binding]; other site
179408004498	G-X-G motif; other site
179408004499	Predicted permeases [General function prediction only]; Region: COG0679
179408004500	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
179408004501	metal ion-dependent adhesion site (MIDAS); other site
179408004502	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
179408004503	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
179408004504	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
179408004505	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
179408004506	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
179408004507	putative NAD(P) binding site [chemical binding]; other site
179408004508	putative substrate binding site [chemical binding]; other site
179408004509	catalytic Zn binding site [ion binding]; other site
179408004510	structural Zn binding site [ion binding]; other site
179408004511	dimer interface [polypeptide binding]; other site
179408004512	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
179408004513	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
179408004514	active site
179408004515	catalytic tetrad [active]
179408004516	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
179408004517	catalytic site [active]
179408004518	putative active site [active]
179408004519	putative substrate binding site [chemical binding]; other site
179408004520	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408004521	putative active site [active]
179408004522	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
179408004523	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
179408004524	CAP-like domain; other site
179408004525	active site
179408004526	primary dimer interface [polypeptide binding]; other site
179408004527	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
179408004528	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
179408004529	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
179408004530	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
179408004531	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
179408004532	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
179408004533	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
179408004534	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
179408004535	active site
179408004536	Zn binding site [ion binding]; other site
179408004537	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
179408004538	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408004539	Walker A/P-loop; other site
179408004540	ATP binding site [chemical binding]; other site
179408004541	Q-loop/lid; other site
179408004542	ABC transporter signature motif; other site
179408004543	Walker B; other site
179408004544	D-loop; other site
179408004545	H-loop/switch region; other site
179408004546	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
179408004547	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408004548	putative active site [active]
179408004549	AAA domain; Region: AAA_22; pfam13401
179408004550	AAA ATPase domain; Region: AAA_16; pfam13191
179408004551	XisI protein; Region: XisI; pfam08869
179408004552	XisH protein; Region: XisH; pfam08814
179408004553	ABC-2 type transporter; Region: ABC2_membrane; cl17235
179408004554	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
179408004555	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
179408004556	FAD binding domain; Region: FAD_binding_4; pfam01565
179408004557	Methyltransferase domain; Region: Methyltransf_31; pfam13847
179408004558	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408004559	S-adenosylmethionine binding site [chemical binding]; other site
179408004560	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
179408004561	Heme NO binding associated; Region: HNOBA; pfam07701
179408004562	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
179408004563	cyclase homology domain; Region: CHD; cd07302
179408004564	nucleotidyl binding site; other site
179408004565	metal binding site [ion binding]; metal-binding site
179408004566	dimer interface [polypeptide binding]; other site
179408004567	Bacterial virulence factor haemolysin; Region: SMP_2; cl11479
179408004568	HAMP domain; Region: HAMP; pfam00672
179408004569	dimerization interface [polypeptide binding]; other site
179408004570	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
179408004571	cyclase homology domain; Region: CHD; cd07302
179408004572	nucleotidyl binding site; other site
179408004573	metal binding site [ion binding]; metal-binding site
179408004574	dimer interface [polypeptide binding]; other site
179408004575	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
179408004576	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
179408004577	inhibitor-cofactor binding pocket; inhibition site
179408004578	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408004579	catalytic residue [active]
179408004580	biotin synthase; Validated; Region: PRK06256
179408004581	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408004582	FeS/SAM binding site; other site
179408004583	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
179408004584	Methyltransferase domain; Region: Methyltransf_23; pfam13489
179408004585	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408004586	S-adenosylmethionine binding site [chemical binding]; other site
179408004587	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
179408004588	NADH(P)-binding; Region: NAD_binding_10; pfam13460
179408004589	NAD(P) binding site [chemical binding]; other site
179408004590	putative active site [active]
179408004591	intracellular protease, PfpI family; Region: PfpI; TIGR01382
179408004592	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
179408004593	conserved cys residue [active]
179408004594	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
179408004595	CsbD-like; Region: CsbD; cl17424
179408004596	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408004597	hypothetical protein; Validated; Region: PRK07413
179408004598	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
179408004599	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
179408004600	Walker A motif; other site
179408004601	homodimer interface [polypeptide binding]; other site
179408004602	ATP binding site [chemical binding]; other site
179408004603	hydroxycobalamin binding site [chemical binding]; other site
179408004604	Walker B motif; other site
179408004605	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
179408004606	putative active site [active]
179408004607	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
179408004608	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
179408004609	Ligand Binding Site [chemical binding]; other site
179408004610	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
179408004611	active site
179408004612	catalytic triad [active]
179408004613	oxyanion hole [active]
179408004614	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
179408004615	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
179408004616	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
179408004617	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
179408004618	Protein of unknown function DUF91; Region: DUF91; cl00709
179408004619	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
179408004620	catalytic core [active]
179408004621	hypothetical protein; Validated; Region: PRK00110
179408004622	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
179408004623	Restriction endonuclease; Region: Mrr_cat; pfam04471
179408004624	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408004625	putative active site [active]
179408004626	CHASE domain; Region: CHASE; pfam03924
179408004627	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
179408004628	cyclase homology domain; Region: CHD; cd07302
179408004629	nucleotidyl binding site; other site
179408004630	metal binding site [ion binding]; metal-binding site
179408004631	dimer interface [polypeptide binding]; other site
179408004632	PAS domain; Region: PAS_9; pfam13426
179408004633	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408004634	putative active site [active]
179408004635	heme pocket [chemical binding]; other site
179408004636	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408004637	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408004638	putative active site [active]
179408004639	heme pocket [chemical binding]; other site
179408004640	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408004641	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408004642	putative active site [active]
179408004643	heme pocket [chemical binding]; other site
179408004644	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408004645	putative active site [active]
179408004646	heme pocket [chemical binding]; other site
179408004647	PAS fold; Region: PAS_4; pfam08448
179408004648	PAS domain S-box; Region: sensory_box; TIGR00229
179408004649	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408004650	putative active site [active]
179408004651	heme pocket [chemical binding]; other site
179408004652	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408004653	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
179408004654	dimer interface [polypeptide binding]; other site
179408004655	phosphorylation site [posttranslational modification]
179408004656	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408004657	ATP binding site [chemical binding]; other site
179408004658	Mg2+ binding site [ion binding]; other site
179408004659	G-X-G motif; other site
179408004660	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408004661	AAA domain; Region: AAA_23; pfam13476
179408004662	Walker A/P-loop; other site
179408004663	ATP binding site [chemical binding]; other site
179408004664	Q-loop/lid; other site
179408004665	exonuclease SbcC; Region: sbcc; TIGR00618
179408004666	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408004667	ABC transporter signature motif; other site
179408004668	Walker B; other site
179408004669	D-loop; other site
179408004670	H-loop/switch region; other site
179408004671	PemK-like protein; Region: PemK; pfam02452
179408004672	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
179408004673	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
179408004674	ligand binding site [chemical binding]; other site
179408004675	flexible hinge region; other site
179408004676	DNA photolyase; Region: DNA_photolyase; pfam00875
179408004677	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
179408004678	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408004679	Probable transposase; Region: OrfB_IS605; pfam01385
179408004680	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408004681	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
179408004682	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
179408004683	active site
179408004684	metal binding site [ion binding]; metal-binding site
179408004685	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
179408004686	Protein of unknown function (DUF3891); Region: DUF3891; pfam13030
179408004687	putative lipid kinase; Reviewed; Region: PRK00861
179408004688	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
179408004689	NACHT domain; Region: NACHT; pfam05729
179408004690	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408004691	WD domain, G-beta repeat; Region: WD40; pfam00400
179408004692	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408004693	WD40 repeats; Region: WD40; smart00320
179408004694	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408004695	structural tetrad; other site
179408004696	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408004697	structural tetrad; other site
179408004698	WD40 repeats; Region: WD40; smart00320
179408004699	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
179408004700	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
179408004701	oligomeric interface; other site
179408004702	putative active site [active]
179408004703	homodimer interface [polypeptide binding]; other site
179408004704	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
179408004705	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
179408004706	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
179408004707	Walker A/P-loop; other site
179408004708	ATP binding site [chemical binding]; other site
179408004709	Q-loop/lid; other site
179408004710	ABC transporter signature motif; other site
179408004711	Walker B; other site
179408004712	D-loop; other site
179408004713	H-loop/switch region; other site
179408004714	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408004715	putative active site [active]
179408004716	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
179408004717	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
179408004718	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
179408004719	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
179408004720	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
179408004721	catalytic motif [active]
179408004722	Zn binding site [ion binding]; other site
179408004723	RibD C-terminal domain; Region: RibD_C; cl17279
179408004724	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
179408004725	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
179408004726	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
179408004727	cofactor binding site; other site
179408004728	DNA binding site [nucleotide binding]
179408004729	substrate interaction site [chemical binding]; other site
179408004730	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
179408004731	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
179408004732	Protein of unknown function (DUF1036); Region: DUF1036; cl02296
179408004733	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
179408004734	PIN domain; Region: PIN_3; pfam13470
179408004735	DNA binding domain, excisionase family; Region: excise; TIGR01764
179408004736	adenylosuccinate lyase; Provisional; Region: PRK07380
179408004737	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
179408004738	tetramer interface [polypeptide binding]; other site
179408004739	active site
179408004740	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
179408004741	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
179408004742	Bacterial SH3 domain; Region: SH3_3; pfam08239
179408004743	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
179408004744	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408004745	putative active site [active]
179408004746	pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144
179408004747	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
179408004748	alpha subunit interface [polypeptide binding]; other site
179408004749	TPP binding site [chemical binding]; other site
179408004750	heterodimer interface [polypeptide binding]; other site
179408004751	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
179408004752	protein-export membrane protein SecD; Region: secD; TIGR01129
179408004753	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
179408004754	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
179408004755	Protein export membrane protein; Region: SecD_SecF; pfam02355
179408004756	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
179408004757	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408004758	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
179408004759	dimer interface [polypeptide binding]; other site
179408004760	phosphorylation site [posttranslational modification]
179408004761	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408004762	ATP binding site [chemical binding]; other site
179408004763	G-X-G motif; other site
179408004764	Domain of unknown function (DUF4342); Region: DUF4342; pfam14242
179408004765	Mg chelatase-related protein; Region: TIGR00368
179408004766	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
179408004767	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408004768	Walker A motif; other site
179408004769	ATP binding site [chemical binding]; other site
179408004770	Walker B motif; other site
179408004771	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
179408004772	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
179408004773	nucleotide binding site/active site [active]
179408004774	HIT family signature motif; other site
179408004775	catalytic residue [active]
179408004776	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
179408004777	protein I interface; other site
179408004778	D2 interface; other site
179408004779	protein T interface; other site
179408004780	chlorophyll binding site; other site
179408004781	beta carotene binding site; other site
179408004782	pheophytin binding site; other site
179408004783	manganese-stabilizing polypeptide interface; other site
179408004784	CP43 interface; other site
179408004785	protein L interface; other site
179408004786	oxygen evolving complex binding site; other site
179408004787	bromide binding site; other site
179408004788	quinone binding site; other site
179408004789	Fe binding site [ion binding]; other site
179408004790	core light harvesting interface; other site
179408004791	cytochrome b559 alpha subunit interface; other site
179408004792	cytochrome c-550 interface; other site
179408004793	protein J interface; other site
179408004794	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
179408004795	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
179408004796	putative active site [active]
179408004797	catalytic triad [active]
179408004798	putative dimer interface [polypeptide binding]; other site
179408004799	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
179408004800	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
179408004801	DHH family; Region: DHH; pfam01368
179408004802	DHHA1 domain; Region: DHHA1; pfam02272
179408004803	Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139
179408004804	Flagellin N-methylase; Region: FliB; pfam03692
179408004805	YGGT family; Region: YGGT; pfam02325
179408004806	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
179408004807	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
179408004808	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
179408004809	NAD(P) binding site [chemical binding]; other site
179408004810	shikimate binding site; other site
179408004811	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
179408004812	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
179408004813	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
179408004814	potential catalytic triad [active]
179408004815	conserved cys residue [active]
179408004816	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
179408004817	phycobillisome linker protein; Region: apcE; CHL00091
179408004818	Phycobilisome protein; Region: Phycobilisome; cl08227
179408004819	Phycobilisome protein; Region: Phycobilisome; cl08227
179408004820	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
179408004821	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
179408004822	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
179408004823	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408004824	S-adenosylmethionine binding site [chemical binding]; other site
179408004825	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
179408004826	putative active site [active]
179408004827	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; cl01562
179408004828	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
179408004829	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408004830	FeS/SAM binding site; other site
179408004831	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
179408004832	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655
179408004833	ATP synthase I chain; Region: ATP_synt_I; pfam03899
179408004834	ATP synthase CF0 A subunit; Region: atpI; CHL00046
179408004835	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
179408004836	F0F1 ATP synthase subunit C; Validated; Region: PRK07354
179408004837	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
179408004838	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
179408004839	F0F1 ATP synthase subunit B; Validated; Region: PRK07352
179408004840	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
179408004841	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
179408004842	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
179408004843	ATP synthase CF1 alpha subunit; Region: atpA; CHL00059
179408004844	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
179408004845	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
179408004846	beta subunit interaction interface [polypeptide binding]; other site
179408004847	Walker A motif; other site
179408004848	ATP binding site [chemical binding]; other site
179408004849	Walker B motif; other site
179408004850	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
179408004851	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
179408004852	core domain interface [polypeptide binding]; other site
179408004853	delta subunit interface [polypeptide binding]; other site
179408004854	epsilon subunit interface [polypeptide binding]; other site
179408004855	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
179408004856	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408004857	non-specific DNA binding site [nucleotide binding]; other site
179408004858	salt bridge; other site
179408004859	sequence-specific DNA binding site [nucleotide binding]; other site
179408004860	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408004861	putative active site [active]
179408004862	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408004863	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
179408004864	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408004865	putative active site [active]
179408004866	putative NTP binding site [chemical binding]; other site
179408004867	putative nucleic acid binding site [nucleotide binding]; other site
179408004868	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408004869	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408004870	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408004871	active site
179408004872	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408004873	putative active site [active]
179408004874	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
179408004875	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
179408004876	catalytic loop [active]
179408004877	iron binding site [ion binding]; other site
179408004878	Protein of unknown function (DUF3326); Region: DUF3326; pfam11805
179408004879	CAAX protease self-immunity; Region: Abi; pfam02517
179408004880	Protein of unknown function (DUF2393); Region: DUF2393; pfam09624
179408004881	TIGR02588 family protein; Region: TIGR02588
179408004882	Putative integral membrane protein (DUF2391); Region: DUF2391; pfam09622
179408004883	PemK-like protein; Region: PemK; pfam02452
179408004884	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
179408004885	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
179408004886	DNA repair protein RadA; Provisional; Region: PRK11823
179408004887	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
179408004888	Walker A motif/ATP binding site; other site
179408004889	ATP binding site [chemical binding]; other site
179408004890	Walker B motif; other site
179408004891	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
179408004892	Ycf27; Reviewed; Region: orf27; CHL00148
179408004893	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408004894	active site
179408004895	phosphorylation site [posttranslational modification]
179408004896	intermolecular recognition site; other site
179408004897	dimerization interface [polypeptide binding]; other site
179408004898	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
179408004899	DNA binding site [nucleotide binding]
179408004900	Protein of unknown function (DUF2930); Region: DUF2930; pfam11152
179408004901	GAF domain; Region: GAF_2; pfam13185
179408004902	cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153
179408004903	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
179408004904	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
179408004905	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
179408004906	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
179408004907	NAD binding site [chemical binding]; other site
179408004908	substrate binding site [chemical binding]; other site
179408004909	homodimer interface [polypeptide binding]; other site
179408004910	active site
179408004911	S-layer homology domain; Region: SLH; pfam00395
179408004912	S-layer homology domain; Region: SLH; pfam00395
179408004913	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408004914	Uncharacterized conserved protein [Function unknown]; Region: COG3391
179408004915	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
179408004916	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
179408004917	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
179408004918	alanine racemase; Reviewed; Region: alr; PRK00053
179408004919	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
179408004920	active site
179408004921	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
179408004922	dimer interface [polypeptide binding]; other site
179408004923	substrate binding site [chemical binding]; other site
179408004924	catalytic residues [active]
179408004925	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
179408004926	Mechanosensitive ion channel; Region: MS_channel; pfam00924
179408004927	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
179408004928	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
179408004929	active site
179408004930	nucleophile elbow; other site
179408004931	Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301
179408004932	GDP-Fucose binding site [chemical binding]; other site
179408004933	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408004934	Probable transposase; Region: OrfB_IS605; pfam01385
179408004935	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408004936	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408004937	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408004938	Probable transposase; Region: OrfB_IS605; pfam01385
179408004939	Transposase IS200 like; Region: Y1_Tnp; pfam01797
179408004940	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
179408004941	NlpC/P60 family; Region: NLPC_P60; pfam00877
179408004942	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
179408004943	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
179408004944	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
179408004945	Putative Catalytic site; other site
179408004946	DXD motif; other site
179408004947	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
179408004948	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
179408004949	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
179408004950	catalytic residue [active]
179408004951	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
179408004952	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
179408004953	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
179408004954	Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617
179408004955	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
179408004956	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408004957	Walker A motif; other site
179408004958	ATP binding site [chemical binding]; other site
179408004959	Walker B motif; other site
179408004960	R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645
179408004961	RxxxH motif; other site
179408004962	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
179408004963	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
179408004964	TPR repeat; Region: TPR_11; pfam13414
179408004965	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408004966	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408004967	binding surface
179408004968	TPR motif; other site
179408004969	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
179408004970	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
179408004971	CHASE3 domain; Region: CHASE3; pfam05227
179408004972	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
179408004973	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
179408004974	dimer interface [polypeptide binding]; other site
179408004975	putative CheW interface [polypeptide binding]; other site
179408004976	Cache domain; Region: Cache_1; pfam02743
179408004977	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
179408004978	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
179408004979	dimer interface [polypeptide binding]; other site
179408004980	putative CheW interface [polypeptide binding]; other site
179408004981	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
179408004982	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
179408004983	putative binding surface; other site
179408004984	active site
179408004985	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
179408004986	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408004987	ATP binding site [chemical binding]; other site
179408004988	Mg2+ binding site [ion binding]; other site
179408004989	G-X-G motif; other site
179408004990	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
179408004991	Response regulator receiver domain; Region: Response_reg; pfam00072
179408004992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408004993	active site
179408004994	phosphorylation site [posttranslational modification]
179408004995	intermolecular recognition site; other site
179408004996	dimerization interface [polypeptide binding]; other site
179408004997	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
179408004998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408004999	active site
179408005000	phosphorylation site [posttranslational modification]
179408005001	intermolecular recognition site; other site
179408005002	dimerization interface [polypeptide binding]; other site
179408005003	CheB methylesterase; Region: CheB_methylest; pfam01339
179408005004	Response regulator receiver domain; Region: Response_reg; pfam00072
179408005005	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408005006	active site
179408005007	phosphorylation site [posttranslational modification]
179408005008	intermolecular recognition site; other site
179408005009	dimerization interface [polypeptide binding]; other site
179408005010	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408005011	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408005012	GAF domain; Region: GAF_3; pfam13492
179408005013	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408005014	GAF domain; Region: GAF; pfam01590
179408005015	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408005016	dimer interface [polypeptide binding]; other site
179408005017	phosphorylation site [posttranslational modification]
179408005018	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408005019	ATP binding site [chemical binding]; other site
179408005020	Mg2+ binding site [ion binding]; other site
179408005021	G-X-G motif; other site
179408005022	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
179408005023	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
179408005024	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
179408005025	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
179408005026	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408005027	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408005028	active site
179408005029	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
179408005030	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
179408005031	Surface antigen; Region: Bac_surface_Ag; pfam01103
179408005032	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
179408005033	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
179408005034	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
179408005035	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
179408005036	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
179408005037	active site
179408005038	catalytic tetrad [active]
179408005039	hydrolase, alpha/beta fold family protein; Region: PLN02824
179408005040	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
179408005041	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
179408005042	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
179408005043	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
179408005044	putative dimer interface [polypeptide binding]; other site
179408005045	putative anticodon binding site; other site
179408005046	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
179408005047	homodimer interface [polypeptide binding]; other site
179408005048	motif 1; other site
179408005049	motif 2; other site
179408005050	active site
179408005051	motif 3; other site
179408005052	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
179408005053	putative active site [active]
179408005054	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
179408005055	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
179408005056	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
179408005057	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
179408005058	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
179408005059	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
179408005060	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
179408005061	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
179408005062	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
179408005063	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408005064	Coenzyme A binding pocket [chemical binding]; other site
179408005065	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
179408005066	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
179408005067	Predicted membrane protein [Function unknown]; Region: COG1950
179408005068	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408005069	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408005070	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408005071	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
179408005072	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
179408005073	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
179408005074	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
179408005075	N-acetyl-D-glucosamine binding site [chemical binding]; other site
179408005076	catalytic residue [active]
179408005077	multifunctional aminopeptidase A; Provisional; Region: PRK00913
179408005078	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
179408005079	interface (dimer of trimers) [polypeptide binding]; other site
179408005080	Substrate-binding/catalytic site; other site
179408005081	Zn-binding sites [ion binding]; other site
179408005082	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408005083	PAS domain; Region: PAS_9; pfam13426
179408005084	putative active site [active]
179408005085	heme pocket [chemical binding]; other site
179408005086	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408005087	PAS fold; Region: PAS_3; pfam08447
179408005088	putative active site [active]
179408005089	heme pocket [chemical binding]; other site
179408005090	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408005091	dimer interface [polypeptide binding]; other site
179408005092	phosphorylation site [posttranslational modification]
179408005093	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408005094	ATP binding site [chemical binding]; other site
179408005095	Mg2+ binding site [ion binding]; other site
179408005096	G-X-G motif; other site
179408005097	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408005098	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408005099	active site
179408005100	ATP binding site [chemical binding]; other site
179408005101	substrate binding site [chemical binding]; other site
179408005102	activation loop (A-loop); other site
179408005103	AAA ATPase domain; Region: AAA_16; pfam13191
179408005104	Predicted ATPase [General function prediction only]; Region: COG3899
179408005105	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408005106	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408005107	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408005108	dimer interface [polypeptide binding]; other site
179408005109	phosphorylation site [posttranslational modification]
179408005110	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408005111	ATP binding site [chemical binding]; other site
179408005112	Mg2+ binding site [ion binding]; other site
179408005113	G-X-G motif; other site
179408005114	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408005115	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408005116	active site
179408005117	ATP binding site [chemical binding]; other site
179408005118	substrate binding site [chemical binding]; other site
179408005119	activation loop (A-loop); other site
179408005120	AAA ATPase domain; Region: AAA_16; pfam13191
179408005121	Predicted ATPase [General function prediction only]; Region: COG3899
179408005122	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408005123	GAF domain; Region: GAF_3; pfam13492
179408005124	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408005125	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408005126	ATP binding site [chemical binding]; other site
179408005127	Mg2+ binding site [ion binding]; other site
179408005128	G-X-G motif; other site
179408005129	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408005130	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408005131	active site
179408005132	ATP binding site [chemical binding]; other site
179408005133	substrate binding site [chemical binding]; other site
179408005134	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
179408005135	substrate binding site [chemical binding]; other site
179408005136	activation loop (A-loop); other site
179408005137	activation loop (A-loop); other site
179408005138	AAA ATPase domain; Region: AAA_16; pfam13191
179408005139	Predicted ATPase [General function prediction only]; Region: COG3899
179408005140	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408005141	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408005142	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408005143	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408005144	ATP binding site [chemical binding]; other site
179408005145	Mg2+ binding site [ion binding]; other site
179408005146	G-X-G motif; other site
179408005147	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
179408005148	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
179408005149	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
179408005150	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
179408005151	Uncharacterized conserved protein [Function unknown]; Region: COG2836
179408005152	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
179408005153	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
179408005154	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
179408005155	catalytic residues [active]
179408005156	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
179408005157	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
179408005158	active site
179408005159	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
179408005160	conserved hypothetical protein; Region: TIGR03492
179408005161	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
179408005162	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
179408005163	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
179408005164	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408005165	active site
179408005166	ATP binding site [chemical binding]; other site
179408005167	substrate binding site [chemical binding]; other site
179408005168	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
179408005169	substrate binding site [chemical binding]; other site
179408005170	activation loop (A-loop); other site
179408005171	activation loop (A-loop); other site
179408005172	AAA ATPase domain; Region: AAA_16; pfam13191
179408005173	Predicted ATPase [General function prediction only]; Region: COG3899
179408005174	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408005175	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408005176	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
179408005177	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408005178	putative active site [active]
179408005179	heme pocket [chemical binding]; other site
179408005180	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408005181	dimer interface [polypeptide binding]; other site
179408005182	phosphorylation site [posttranslational modification]
179408005183	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408005184	ATP binding site [chemical binding]; other site
179408005185	Mg2+ binding site [ion binding]; other site
179408005186	G-X-G motif; other site
179408005187	Response regulator receiver domain; Region: Response_reg; pfam00072
179408005188	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408005189	active site
179408005190	phosphorylation site [posttranslational modification]
179408005191	intermolecular recognition site; other site
179408005192	dimerization interface [polypeptide binding]; other site
179408005193	Response regulator receiver domain; Region: Response_reg; pfam00072
179408005194	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408005195	active site
179408005196	phosphorylation site [posttranslational modification]
179408005197	intermolecular recognition site; other site
179408005198	dimerization interface [polypeptide binding]; other site
179408005199	PAS fold; Region: PAS_4; pfam08448
179408005200	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
179408005201	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
179408005202	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
179408005203	DNA binding residues [nucleotide binding]
179408005204	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408005205	TPR motif; other site
179408005206	binding surface
179408005207	TPR repeat; Region: TPR_11; pfam13414
179408005208	TPR repeat; Region: TPR_11; pfam13414
179408005209	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408005210	TPR motif; other site
179408005211	binding surface
179408005212	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408005213	TPR motif; other site
179408005214	TPR repeat; Region: TPR_11; pfam13414
179408005215	binding surface
179408005216	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408005217	binding surface
179408005218	TPR motif; other site
179408005219	Beta/Gamma crystallin; Region: Crystall; cl02528
179408005220	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
179408005221	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
179408005222	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408005223	Walker A/P-loop; other site
179408005224	ATP binding site [chemical binding]; other site
179408005225	Q-loop/lid; other site
179408005226	ABC transporter signature motif; other site
179408005227	Walker B; other site
179408005228	D-loop; other site
179408005229	H-loop/switch region; other site
179408005230	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408005231	S-adenosylmethionine binding site [chemical binding]; other site
179408005232	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
179408005233	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
179408005234	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
179408005235	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408005236	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408005237	TPR motif; other site
179408005238	binding surface
179408005239	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408005240	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
179408005241	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
179408005242	active site
179408005243	metal binding site [ion binding]; metal-binding site
179408005244	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
179408005245	proton extrusion protein PcxA; Provisional; Region: PRK02507
179408005246	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408005247	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
179408005248	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
179408005249	intracellular protease, PfpI family; Region: PfpI; TIGR01382
179408005250	proposed catalytic triad [active]
179408005251	conserved cys residue [active]
179408005252	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
179408005253	dinuclear metal binding motif [ion binding]; other site
179408005254	PAS domain S-box; Region: sensory_box; TIGR00229
179408005255	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408005256	putative active site [active]
179408005257	heme pocket [chemical binding]; other site
179408005258	PAS domain S-box; Region: sensory_box; TIGR00229
179408005259	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408005260	putative active site [active]
179408005261	heme pocket [chemical binding]; other site
179408005262	PAS domain S-box; Region: sensory_box; TIGR00229
179408005263	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408005264	putative active site [active]
179408005265	heme pocket [chemical binding]; other site
179408005266	PAS domain S-box; Region: sensory_box; TIGR00229
179408005267	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408005268	putative active site [active]
179408005269	heme pocket [chemical binding]; other site
179408005270	PAS domain S-box; Region: sensory_box; TIGR00229
179408005271	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408005272	putative active site [active]
179408005273	heme pocket [chemical binding]; other site
179408005274	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408005275	PAS fold; Region: PAS_3; pfam08447
179408005276	putative active site [active]
179408005277	heme pocket [chemical binding]; other site
179408005278	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408005279	dimer interface [polypeptide binding]; other site
179408005280	phosphorylation site [posttranslational modification]
179408005281	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408005282	ATP binding site [chemical binding]; other site
179408005283	Mg2+ binding site [ion binding]; other site
179408005284	G-X-G motif; other site
179408005285	Response regulator receiver domain; Region: Response_reg; pfam00072
179408005286	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408005287	active site
179408005288	phosphorylation site [posttranslational modification]
179408005289	intermolecular recognition site; other site
179408005290	dimerization interface [polypeptide binding]; other site
179408005291	Response regulator receiver domain; Region: Response_reg; pfam00072
179408005292	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408005293	active site
179408005294	phosphorylation site [posttranslational modification]
179408005295	intermolecular recognition site; other site
179408005296	dimerization interface [polypeptide binding]; other site
179408005297	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408005298	PAS domain; Region: PAS_9; pfam13426
179408005299	putative active site [active]
179408005300	heme pocket [chemical binding]; other site
179408005301	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408005302	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408005303	metal binding site [ion binding]; metal-binding site
179408005304	active site
179408005305	I-site; other site
179408005306	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
179408005307	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
179408005308	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
179408005309	putative NAD(P) binding site [chemical binding]; other site
179408005310	Sec-independent translocase component C; Provisional; Region: tatC; CHL00182
179408005311	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
179408005312	TAP-like protein; Region: Abhydrolase_4; pfam08386
179408005313	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
179408005314	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
179408005315	Hexamer interface [polypeptide binding]; other site
179408005316	Hexagonal pore residue; other site
179408005317	Protein of unknown function (DUF3067); Region: DUF3067; pfam11267
179408005318	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
179408005319	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
179408005320	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
179408005321	cytochrome b subunit interaction site [polypeptide binding]; other site
179408005322	[2Fe-2S] cluster binding site [ion binding]; other site
179408005323	apocytochrome f; Reviewed; Region: PRK02693
179408005324	cytochrome f; Region: petA; CHL00037
179408005325	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
179408005326	haloalkane dehalogenase; Provisional; Region: PRK03592
179408005327	photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042
179408005328	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
179408005329	hydroxyglutarate oxidase; Provisional; Region: PRK11728
179408005330	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
179408005331	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
179408005332	nudix motif; other site
179408005333	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
179408005334	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
179408005335	Zn binding site [ion binding]; other site
179408005336	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
179408005337	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
179408005338	putative active site; other site
179408005339	catalytic residue [active]
179408005340	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
179408005341	Response regulator receiver domain; Region: Response_reg; pfam00072
179408005342	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408005343	active site
179408005344	phosphorylation site [posttranslational modification]
179408005345	intermolecular recognition site; other site
179408005346	dimerization interface [polypeptide binding]; other site
179408005347	Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651
179408005348	HEAT repeats; Region: HEAT_2; pfam13646
179408005349	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
179408005350	protein binding surface [polypeptide binding]; other site
179408005351	HEAT repeats; Region: HEAT_2; pfam13646
179408005352	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
179408005353	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
179408005354	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
179408005355	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
179408005356	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
179408005357	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
179408005358	Phycobilisome protein; Region: Phycobilisome; cl08227
179408005359	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
179408005360	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
179408005361	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
179408005362	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
179408005363	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
179408005364	motif II; other site
179408005365	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
179408005366	recombination protein F; Reviewed; Region: recF; PRK00064
179408005367	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
179408005368	Walker A/P-loop; other site
179408005369	ATP binding site [chemical binding]; other site
179408005370	Q-loop/lid; other site
179408005371	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408005372	ABC transporter signature motif; other site
179408005373	Walker B; other site
179408005374	D-loop; other site
179408005375	H-loop/switch region; other site
179408005376	photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044
179408005377	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
179408005378	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
179408005379	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
179408005380	NodB motif; other site
179408005381	active site
179408005382	catalytic site [active]
179408005383	metal binding site [ion binding]; metal-binding site
179408005384	bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424
179408005385	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
179408005386	short chain dehydrogenase; Provisional; Region: PRK12367
179408005387	NAD(P) binding site [chemical binding]; other site
179408005388	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
179408005389	active site
179408005390	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
179408005391	putative active site pocket [active]
179408005392	dimerization interface [polypeptide binding]; other site
179408005393	putative catalytic residue [active]
179408005394	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
179408005395	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
179408005396	Mg2+ binding site [ion binding]; other site
179408005397	Putative zinc-finger; Region: zf-HC2; pfam13490
179408005398	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
179408005399	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
179408005400	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
179408005401	DNA binding residues [nucleotide binding]
179408005402	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
179408005403	MoaE homodimer interface [polypeptide binding]; other site
179408005404	MoaD interaction [polypeptide binding]; other site
179408005405	active site residues [active]
179408005406	Bacterial SH3 domain; Region: SH3_3; cl17532
179408005407	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
179408005408	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
179408005409	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
179408005410	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
179408005411	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
179408005412	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
179408005413	phosphopeptide binding site; other site
179408005414	Double zinc ribbon; Region: DZR; pfam12773
179408005415	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408005416	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408005417	active site
179408005418	ATP binding site [chemical binding]; other site
179408005419	substrate binding site [chemical binding]; other site
179408005420	activation loop (A-loop); other site
179408005421	Double zinc ribbon; Region: DZR; pfam12773
179408005422	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
179408005423	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
179408005424	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
179408005425	active site
179408005426	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
179408005427	DHH family; Region: DHH; pfam01368
179408005428	DHHA1 domain; Region: DHHA1; pfam02272
179408005429	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
179408005430	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
179408005431	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
179408005432	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408005433	putative active site [active]
179408005434	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408005435	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408005436	Probable transposase; Region: OrfB_IS605; pfam01385
179408005437	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408005438	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408005439	non-specific DNA binding site [nucleotide binding]; other site
179408005440	salt bridge; other site
179408005441	sequence-specific DNA binding site [nucleotide binding]; other site
179408005442	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
179408005443	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
179408005444	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408005445	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
179408005446	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
179408005447	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
179408005448	Mg++ binding site [ion binding]; other site
179408005449	putative catalytic motif [active]
179408005450	putative substrate binding site [chemical binding]; other site
179408005451	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
179408005452	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408005453	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408005454	active site
179408005455	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
179408005456	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
179408005457	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
179408005458	active site clefts [active]
179408005459	zinc binding site [ion binding]; other site
179408005460	dimer interface [polypeptide binding]; other site
179408005461	NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363
179408005462	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
179408005463	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
179408005464	CO2 hydration protein (ChpXY); Region: ChpXY; cl10905
179408005465	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408005466	non-specific DNA binding site [nucleotide binding]; other site
179408005467	salt bridge; other site
179408005468	sequence-specific DNA binding site [nucleotide binding]; other site
179408005469	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408005470	Probable transposase; Region: OrfB_IS605; pfam01385
179408005471	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408005472	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408005473	non-specific DNA binding site [nucleotide binding]; other site
179408005474	salt bridge; other site
179408005475	sequence-specific DNA binding site [nucleotide binding]; other site
179408005476	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408005477	non-specific DNA binding site [nucleotide binding]; other site
179408005478	salt bridge; other site
179408005479	sequence-specific DNA binding site [nucleotide binding]; other site
179408005480	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
179408005481	apolar tunnel; other site
179408005482	heme binding site [chemical binding]; other site
179408005483	dimerization interface [polypeptide binding]; other site
179408005484	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
179408005485	Transposase [DNA replication, recombination, and repair]; Region: COG5421
179408005486	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
179408005487	photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199
179408005488	photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200
179408005489	ribonuclease E; Reviewed; Region: rne; PRK10811
179408005490	Methyltransferase domain; Region: Methyltransf_31; pfam13847
179408005491	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408005492	S-adenosylmethionine binding site [chemical binding]; other site
179408005493	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
179408005494	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
179408005495	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
179408005496	catalytic residues [active]
179408005497	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
179408005498	tetramer interface [polypeptide binding]; other site
179408005499	dimer interface [polypeptide binding]; other site
179408005500	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
179408005501	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
179408005502	Walker A motif; other site
179408005503	ATP binding site [chemical binding]; other site
179408005504	Walker B motif; other site
179408005505	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
179408005506	Amidase; Region: Amidase; pfam01425
179408005507	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
179408005508	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
179408005509	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
179408005510	Ligand Binding Site [chemical binding]; other site
179408005511	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
179408005512	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
179408005513	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
179408005514	ketol-acid reductoisomerase; Provisional; Region: PRK05479
179408005515	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
179408005516	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
179408005517	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
179408005518	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
179408005519	putative metal binding site [ion binding]; other site
179408005520	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
179408005521	putative catalytic site [active]
179408005522	putative metal binding site [ion binding]; other site
179408005523	putative phosphate binding site [ion binding]; other site
179408005524	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
179408005525	Dynamin family; Region: Dynamin_N; pfam00350
179408005526	G1 box; other site
179408005527	GTP/Mg2+ binding site [chemical binding]; other site
179408005528	G2 box; other site
179408005529	Switch I region; other site
179408005530	G3 box; other site
179408005531	Switch II region; other site
179408005532	G4 box; other site
179408005533	G5 box; other site
179408005534	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
179408005535	Dynamin family; Region: Dynamin_N; pfam00350
179408005536	G1 box; other site
179408005537	GTP/Mg2+ binding site [chemical binding]; other site
179408005538	G2 box; other site
179408005539	Switch I region; other site
179408005540	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
179408005541	G3 box; other site
179408005542	Switch II region; other site
179408005543	GTP/Mg2+ binding site [chemical binding]; other site
179408005544	G4 box; other site
179408005545	G5 box; other site
179408005546	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408005547	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408005548	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408005549	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408005550	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408005551	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
179408005552	NADPH bind site [chemical binding]; other site
179408005553	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
179408005554	putative FMN binding site [chemical binding]; other site
179408005555	NADPH bind site [chemical binding]; other site
179408005556	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
179408005557	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
179408005558	trmE is a tRNA modification GTPase; Region: trmE; cd04164
179408005559	G1 box; other site
179408005560	GTP/Mg2+ binding site [chemical binding]; other site
179408005561	Switch I region; other site
179408005562	G2 box; other site
179408005563	Switch II region; other site
179408005564	G3 box; other site
179408005565	G4 box; other site
179408005566	G5 box; other site
179408005567	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
179408005568	Protein kinase domain; Region: Pkinase; pfam00069
179408005569	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408005570	active site
179408005571	ATP binding site [chemical binding]; other site
179408005572	substrate binding site [chemical binding]; other site
179408005573	activation loop (A-loop); other site
179408005574	TPR repeat; Region: TPR_11; pfam13414
179408005575	TPR repeat; Region: TPR_11; pfam13414
179408005576	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408005577	binding surface
179408005578	TPR motif; other site
179408005579	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408005580	binding surface
179408005581	TPR motif; other site
179408005582	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
179408005583	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408005584	binding surface
179408005585	TPR motif; other site
179408005586	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408005587	binding surface
179408005588	TPR motif; other site
179408005589	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408005590	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408005591	active site
179408005592	ATP binding site [chemical binding]; other site
179408005593	substrate binding site [chemical binding]; other site
179408005594	activation loop (A-loop); other site
179408005595	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408005596	TPR motif; other site
179408005597	TPR repeat; Region: TPR_11; pfam13414
179408005598	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408005599	TPR motif; other site
179408005600	binding surface
179408005601	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
179408005602	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408005603	binding surface
179408005604	TPR motif; other site
179408005605	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408005606	binding surface
179408005607	TPR motif; other site
179408005608	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408005609	binding surface
179408005610	TPR motif; other site
179408005611	Uncharacterized conserved protein [Function unknown]; Region: COG0397
179408005612	hypothetical protein; Validated; Region: PRK00029
179408005613	Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354
179408005614	beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215
179408005615	Protein of unknown function, DUF608; Region: DUF608; pfam04685
179408005616	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408005617	putative active site [active]
179408005618	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408005619	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408005620	binding surface
179408005621	TPR motif; other site
179408005622	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408005623	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408005624	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408005625	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408005626	binding surface
179408005627	TPR motif; other site
179408005628	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408005629	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408005630	binding surface
179408005631	TPR motif; other site
179408005632	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408005633	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408005634	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408005635	binding surface
179408005636	TPR motif; other site
179408005637	TPR repeat; Region: TPR_11; pfam13414
179408005638	CHAT domain; Region: CHAT; pfam12770
179408005639	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
179408005640	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
179408005641	trimer interface [polypeptide binding]; other site
179408005642	putative metal binding site [ion binding]; other site
179408005643	Protein of unknown function (DUF2396); Region: DUF2396; pfam09654
179408005644	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
179408005645	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
179408005646	active site
179408005647	metal binding site [ion binding]; metal-binding site
179408005648	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
179408005649	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
179408005650	Soluble P-type ATPase [General function prediction only]; Region: COG4087
179408005651	manganese transport protein MntH; Reviewed; Region: PRK00701
179408005652	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
179408005653	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
179408005654	C-terminal peptidase (prc); Region: prc; TIGR00225
179408005655	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
179408005656	protein binding site [polypeptide binding]; other site
179408005657	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
179408005658	Catalytic dyad [active]
179408005659	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
179408005660	pseudouridine synthase; Region: TIGR00093
179408005661	active site
179408005662	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
179408005663	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
179408005664	active site
179408005665	homodimer interface [polypeptide binding]; other site
179408005666	Repair protein; Region: Repair_PSII; pfam04536
179408005667	Thioredoxin domain-containing protein; Provisional; Region: PTZ00443
179408005668	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
179408005669	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
179408005670	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870
179408005671	UbiA prenyltransferase family; Region: UbiA; pfam01040
179408005672	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
179408005673	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
179408005674	HD domain; Region: HD; pfam01966
179408005675	Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237
179408005676	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408005677	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
179408005678	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
179408005679	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408005680	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
179408005681	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408005682	active site
179408005683	phosphorylation site [posttranslational modification]
179408005684	intermolecular recognition site; other site
179408005685	dimerization interface [polypeptide binding]; other site
179408005686	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
179408005687	DNA binding residues [nucleotide binding]
179408005688	dimerization interface [polypeptide binding]; other site
179408005689	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408005690	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408005691	dimer interface [polypeptide binding]; other site
179408005692	phosphorylation site [posttranslational modification]
179408005693	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408005694	ATP binding site [chemical binding]; other site
179408005695	Mg2+ binding site [ion binding]; other site
179408005696	G-X-G motif; other site
179408005697	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
179408005698	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
179408005699	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
179408005700	Soluble P-type ATPase [General function prediction only]; Region: COG4087
179408005701	F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604
179408005702	K+-transporting ATPase, c chain; Region: KdpC; cl00944
179408005703	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
179408005704	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
179408005705	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
179408005706	Ligand Binding Site [chemical binding]; other site
179408005707	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
179408005708	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
179408005709	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408005710	S-adenosylmethionine binding site [chemical binding]; other site
179408005711	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837
179408005712	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
179408005713	BT1 family; Region: BT1; pfam03092
179408005714	putative substrate translocation pore; other site
179408005715	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
179408005716	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
179408005717	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
179408005718	active site
179408005719	catalytic triad [active]
179408005720	oxyanion hole [active]
179408005721	Protein of unknown function (DUF4087); Region: DUF4087; pfam13316
179408005722	Predicted integral membrane protein [Function unknown]; Region: COG5500
179408005723	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
179408005724	oxyanion hole [active]
179408005725	RDD family; Region: RDD; pfam06271
179408005726	ribosomal protein L33; Region: rpl33; CHL00104
179408005727	ribosomal protein S18; Region: rps18; CHL00077
179408005728	Exoribonuclease R [Transcription]; Region: VacB; COG0557
179408005729	RNB domain; Region: RNB; pfam00773
179408005730	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
179408005731	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408005732	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408005733	dimer interface [polypeptide binding]; other site
179408005734	phosphorylation site [posttranslational modification]
179408005735	putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947
179408005736	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
179408005737	Transcriptional activator RinB; Region: RinB; pfam06116
179408005738	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
179408005739	binding surface
179408005740	TPR motif; other site
179408005741	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408005742	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408005743	binding surface
179408005744	TPR motif; other site
179408005745	TPR repeat; Region: TPR_11; pfam13414
179408005746	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
179408005747	SmpB-tmRNA interface; other site
179408005748	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
179408005749	PEP-CTERM family integral membrane protein; Region: PEP_integral; TIGR02921
179408005750	Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146
179408005751	iron-sulfur cluster [ion binding]; other site
179408005752	[2Fe-2S] cluster binding site [ion binding]; other site
179408005753	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408005754	non-specific DNA binding site [nucleotide binding]; other site
179408005755	salt bridge; other site
179408005756	sequence-specific DNA binding site [nucleotide binding]; other site
179408005757	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408005758	non-specific DNA binding site [nucleotide binding]; other site
179408005759	salt bridge; other site
179408005760	sequence-specific DNA binding site [nucleotide binding]; other site
179408005761	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408005762	non-specific DNA binding site [nucleotide binding]; other site
179408005763	salt bridge; other site
179408005764	sequence-specific DNA binding site [nucleotide binding]; other site
179408005765	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
179408005766	HAS barrel domain; Region: HAS-barrel; pfam09378
179408005767	Protein of unknown function (DUF3252); Region: DUF3252; pfam11623
179408005768	antiporter inner membrane protein; Provisional; Region: PRK11670
179408005769	Domain of unknown function DUF59; Region: DUF59; pfam01883
179408005770	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
179408005771	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
179408005772	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
179408005773	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
179408005774	anti sigma factor interaction site; other site
179408005775	regulatory phosphorylation site [posttranslational modification]; other site
179408005776	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
179408005777	Thf1-like protein; Reviewed; Region: PRK13266
179408005778	photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060
179408005779	Late competence development protein ComFB; Region: ComFB; pfam10719
179408005780	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
179408005781	Peptidase family M23; Region: Peptidase_M23; pfam01551
179408005782	Uncharacterized conserved protein [Function unknown]; Region: COG1262
179408005783	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
179408005784	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
179408005785	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
179408005786	active site
179408005787	substrate binding site [chemical binding]; other site
179408005788	metal binding site [ion binding]; metal-binding site
179408005789	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
179408005790	active site
179408005791	phosphate binding residues; other site
179408005792	catalytic residues [active]
179408005793	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
179408005794	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
179408005795	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
179408005796	TrkA-N domain; Region: TrkA_N; pfam02254
179408005797	TrkA-C domain; Region: TrkA_C; pfam02080
179408005798	TrkA-C domain; Region: TrkA_C; pfam02080
179408005799	Sm and related proteins; Region: Sm_like; cl00259
179408005800	heptamer interface [polypeptide binding]; other site
179408005801	Sm1 motif; other site
179408005802	hexamer interface [polypeptide binding]; other site
179408005803	RNA binding site [nucleotide binding]; other site
179408005804	Sm2 motif; other site
179408005805	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
179408005806	diaminopimelate epimerase; Region: PLN02536
179408005807	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
179408005808	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
179408005809	Dynamin family; Region: Dynamin_N; pfam00350
179408005810	G1 box; other site
179408005811	GTP/Mg2+ binding site [chemical binding]; other site
179408005812	aspartate aminotransferase; Provisional; Region: PRK05942
179408005813	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
179408005814	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408005815	homodimer interface [polypeptide binding]; other site
179408005816	catalytic residue [active]
179408005817	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
179408005818	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
179408005819	putative active site [active]
179408005820	metal binding site [ion binding]; metal-binding site
179408005821	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
179408005822	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
179408005823	Catalytic site [active]
179408005824	PemK-like protein; Region: PemK; pfam02452
179408005825	GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541
179408005826	GIY-YIG motif/motif A; other site
179408005827	active site
179408005828	catalytic site [active]
179408005829	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
179408005830	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
179408005831	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
179408005832	ATP binding site [chemical binding]; other site
179408005833	putative Mg++ binding site [ion binding]; other site
179408005834	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
179408005835	nucleotide binding region [chemical binding]; other site
179408005836	ATP-binding site [chemical binding]; other site
179408005837	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
179408005838	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
179408005839	Aspartase; Region: Aspartase; cd01357
179408005840	active sites [active]
179408005841	tetramer interface [polypeptide binding]; other site
179408005842	Uncharacterized conserved protein [Function unknown]; Region: COG2006
179408005843	Domain of unknown function (DUF362); Region: DUF362; pfam04015
179408005844	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408005845	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
179408005846	S-adenosylmethionine synthetase; Validated; Region: PRK05250
179408005847	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
179408005848	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
179408005849	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
179408005850	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
179408005851	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
179408005852	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
179408005853	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
179408005854	HEAT repeats; Region: HEAT_2; pfam13646
179408005855	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
179408005856	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408005857	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408005858	dimerization interface [polypeptide binding]; other site
179408005859	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408005860	dimer interface [polypeptide binding]; other site
179408005861	phosphorylation site [posttranslational modification]
179408005862	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408005863	ATP binding site [chemical binding]; other site
179408005864	Mg2+ binding site [ion binding]; other site
179408005865	G-X-G motif; other site
179408005866	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
179408005867	protein I interface; other site
179408005868	D2 interface; other site
179408005869	protein T interface; other site
179408005870	chlorophyll binding site; other site
179408005871	beta carotene binding site; other site
179408005872	pheophytin binding site; other site
179408005873	manganese-stabilizing polypeptide interface; other site
179408005874	CP43 interface; other site
179408005875	protein L interface; other site
179408005876	oxygen evolving complex binding site; other site
179408005877	bromide binding site; other site
179408005878	quinone binding site; other site
179408005879	Fe binding site [ion binding]; other site
179408005880	core light harvesting interface; other site
179408005881	cytochrome b559 alpha subunit interface; other site
179408005882	cytochrome c-550 interface; other site
179408005883	protein J interface; other site
179408005884	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
179408005885	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
179408005886	Predicted ATPase [General function prediction only]; Region: COG4637
179408005887	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408005888	Walker A/P-loop; other site
179408005889	ATP binding site [chemical binding]; other site
179408005890	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
179408005891	Q-loop/lid; other site
179408005892	ABC transporter signature motif; other site
179408005893	Walker B; other site
179408005894	D-loop; other site
179408005895	H-loop/switch region; other site
179408005896	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
179408005897	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
179408005898	dimer interface [polypeptide binding]; other site
179408005899	active site
179408005900	acyl carrier protein; Provisional; Region: acpP; PRK00982
179408005901	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
179408005902	Cysteine-rich domain; Region: CCG; pfam02754
179408005903	Cysteine-rich domain; Region: CCG; pfam02754
179408005904	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
179408005905	Cl- selectivity filter; other site
179408005906	Cl- binding residues [ion binding]; other site
179408005907	pore gating glutamate residue; other site
179408005908	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
179408005909	dimer interface [polypeptide binding]; other site
179408005910	photosystem I subunit VII; Region: psaC; CHL00065
179408005911	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
179408005912	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
179408005913	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
179408005914	glutaminase active site [active]
179408005915	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
179408005916	dimer interface [polypeptide binding]; other site
179408005917	active site
179408005918	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
179408005919	dimer interface [polypeptide binding]; other site
179408005920	active site
179408005921	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
179408005922	O-Antigen ligase; Region: Wzy_C; pfam04932
179408005923	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
179408005924	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
179408005925	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
179408005926	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408005927	putative active site [active]
179408005928	Putative restriction endonuclease; Region: Uma2; pfam05685
179408005929	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
179408005930	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
179408005931	NodB motif; other site
179408005932	active site
179408005933	catalytic site [active]
179408005934	metal binding site [ion binding]; metal-binding site
179408005935	bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477
179408005936	Pantoate-beta-alanine ligase; Region: PanC; cd00560
179408005937	active site
179408005938	ATP-binding site [chemical binding]; other site
179408005939	pantoate-binding site; other site
179408005940	HXXH motif; other site
179408005941	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
179408005942	CMP-binding site; other site
179408005943	The sites determining sugar specificity; other site
179408005944	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
179408005945	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
179408005946	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
179408005947	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
179408005948	dimerization interface [polypeptide binding]; other site
179408005949	putative ATP binding site [chemical binding]; other site
179408005950	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408005951	putative active site [active]
179408005952	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
179408005953	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
179408005954	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
179408005955	anti sigma factor interaction site; other site
179408005956	regulatory phosphorylation site [posttranslational modification]; other site
179408005957	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
179408005958	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
179408005959	active site
179408005960	intersubunit interface [polypeptide binding]; other site
179408005961	Zn2+ binding site [ion binding]; other site
179408005962	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
179408005963	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
179408005964	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
179408005965	Tetramer interface [polypeptide binding]; other site
179408005966	active site
179408005967	FMN-binding site [chemical binding]; other site
179408005968	Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468
179408005969	photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624
179408005970	twin arginine translocase protein A; Provisional; Region: tatA; PRK14857
179408005971	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
179408005972	putative active site [active]
179408005973	catalytic residue [active]
179408005974	Protein of unknown function (DUF3146); Region: DUF3146; pfam11344
179408005975	CAAX protease self-immunity; Region: Abi; pfam02517
179408005976	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
179408005977	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
179408005978	G1 box; other site
179408005979	GTP/Mg2+ binding site [chemical binding]; other site
179408005980	Switch I region; other site
179408005981	G2 box; other site
179408005982	Switch II region; other site
179408005983	G3 box; other site
179408005984	G4 box; other site
179408005985	G5 box; other site
179408005986	Domain of unknown function (DUF697); Region: DUF697; pfam05128
179408005987	RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623
179408005988	3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074
179408005989	Methyltransferase domain; Region: Methyltransf_12; pfam08242
179408005990	polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075
179408005991	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408005992	Walker A/P-loop; other site
179408005993	ATP binding site [chemical binding]; other site
179408005994	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
179408005995	active site
179408005996	metal binding site [ion binding]; metal-binding site
179408005997	argininosuccinate synthase; Provisional; Region: PRK13820
179408005998	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
179408005999	ANP binding site [chemical binding]; other site
179408006000	Substrate Binding Site II [chemical binding]; other site
179408006001	Substrate Binding Site I [chemical binding]; other site
179408006002	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
179408006003	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
179408006004	active site
179408006005	Response regulator receiver domain; Region: Response_reg; pfam00072
179408006006	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408006007	active site
179408006008	phosphorylation site [posttranslational modification]
179408006009	intermolecular recognition site; other site
179408006010	dimerization interface [polypeptide binding]; other site
179408006011	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006012	PAS fold; Region: PAS_3; pfam08447
179408006013	putative active site [active]
179408006014	heme pocket [chemical binding]; other site
179408006015	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408006016	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408006017	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006018	PAS fold; Region: PAS_3; pfam08447
179408006019	putative active site [active]
179408006020	heme pocket [chemical binding]; other site
179408006021	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006022	PAS fold; Region: PAS_3; pfam08447
179408006023	putative active site [active]
179408006024	heme pocket [chemical binding]; other site
179408006025	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408006026	dimer interface [polypeptide binding]; other site
179408006027	phosphorylation site [posttranslational modification]
179408006028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408006029	ATP binding site [chemical binding]; other site
179408006030	Mg2+ binding site [ion binding]; other site
179408006031	G-X-G motif; other site
179408006032	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
179408006033	Amidinotransferase; Region: Amidinotransf; cl12043
179408006034	Uncharacterized conserved protein [Function unknown]; Region: COG1915
179408006035	Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144
179408006036	homodimer interface [polypeptide binding]; other site
179408006037	citrate synthase; Provisional; Region: PRK14036
179408006038	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
179408006039	oxalacetate binding site [chemical binding]; other site
179408006040	citrylCoA binding site [chemical binding]; other site
179408006041	coenzyme A binding site [chemical binding]; other site
179408006042	catalytic triad [active]
179408006043	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
179408006044	catalytic core [active]
179408006045	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408006046	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006047	putative active site [active]
179408006048	heme pocket [chemical binding]; other site
179408006049	PAS domain S-box; Region: sensory_box; TIGR00229
179408006050	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006051	putative active site [active]
179408006052	heme pocket [chemical binding]; other site
179408006053	GAF domain; Region: GAF_3; pfam13492
179408006054	GAF domain; Region: GAF_2; pfam13185
179408006055	PAS domain S-box; Region: sensory_box; TIGR00229
179408006056	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006057	putative active site [active]
179408006058	heme pocket [chemical binding]; other site
179408006059	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408006060	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408006061	metal binding site [ion binding]; metal-binding site
179408006062	active site
179408006063	I-site; other site
179408006064	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
179408006065	Transposase [DNA replication, recombination, and repair]; Region: COG5421
179408006066	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408006067	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408006068	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
179408006069	DHH family; Region: DHH; pfam01368
179408006070	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408006071	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408006072	active site
179408006073	Circadian oscillating protein COP23; Region: COP23; pfam14218
179408006074	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408006075	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408006076	structural tetrad; other site
179408006077	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
179408006078	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
179408006079	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408006080	putative active site [active]
179408006081	TIR domain; Region: TIR_2; pfam13676
179408006082	AMIN domain; Region: AMIN; pfam11741
179408006083	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
179408006084	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
179408006085	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
179408006086	dimer interface [polypeptide binding]; other site
179408006087	ligand binding site [chemical binding]; other site
179408006088	GUN4-like; Region: GUN4; pfam05419
179408006089	Domain of unknown function (DUF4342); Region: DUF4342; pfam14242
179408006090	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408006091	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408006092	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
179408006093	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
179408006094	XisI protein; Region: XisI; pfam08869
179408006095	XisH protein; Region: XisH; pfam08814
179408006096	Protein of unknown function (DUF433); Region: DUF433; cl01030
179408006097	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
179408006098	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
179408006099	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
179408006100	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
179408006101	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
179408006102	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
179408006103	putative ligand binding site [chemical binding]; other site
179408006104	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
179408006105	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
179408006106	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408006107	FeS/SAM binding site; other site
179408006108	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
179408006109	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408006110	S-adenosylmethionine binding site [chemical binding]; other site
179408006111	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
179408006112	ligand binding site [chemical binding]; other site
179408006113	flexible hinge region; other site
179408006114	Protein of unknown function (DUF1517); Region: DUF1517; pfam07466
179408006115	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
179408006116	dimer interface [polypeptide binding]; other site
179408006117	active site
179408006118	Schiff base residues; other site
179408006119	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
179408006120	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408006121	Coenzyme A binding pocket [chemical binding]; other site
179408006122	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408006123	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408006124	dimer interface [polypeptide binding]; other site
179408006125	phosphorylation site [posttranslational modification]
179408006126	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
179408006127	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
179408006128	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
179408006129	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408006130	Tic22-like family; Region: Tic22; pfam04278
179408006131	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408006132	Coenzyme A binding pocket [chemical binding]; other site
179408006133	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408006134	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408006135	Probable transposase; Region: OrfB_IS605; pfam01385
179408006136	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408006137	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
179408006138	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
179408006139	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408006140	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408006141	Probable transposase; Region: OrfB_IS605; pfam01385
179408006142	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408006143	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
179408006144	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
179408006145	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
179408006146	active site
179408006147	HIGH motif; other site
179408006148	KMSKS motif; other site
179408006149	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
179408006150	tRNA binding surface [nucleotide binding]; other site
179408006151	anticodon binding site; other site
179408006152	Uncharacterized conserved protein [Function unknown]; Region: COG1432
179408006153	LabA_like proteins; Region: LabA; cd10911
179408006154	putative metal binding site [ion binding]; other site
179408006155	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
179408006156	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408006157	putative active site [active]
179408006158	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408006159	putative active site [active]
179408006160	Cache domain; Region: Cache_1; pfam02743
179408006161	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408006162	dimerization interface [polypeptide binding]; other site
179408006163	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408006164	dimer interface [polypeptide binding]; other site
179408006165	phosphorylation site [posttranslational modification]
179408006166	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408006167	ATP binding site [chemical binding]; other site
179408006168	Mg2+ binding site [ion binding]; other site
179408006169	G-X-G motif; other site
179408006170	Response regulator receiver domain; Region: Response_reg; pfam00072
179408006171	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408006172	active site
179408006173	phosphorylation site [posttranslational modification]
179408006174	intermolecular recognition site; other site
179408006175	dimerization interface [polypeptide binding]; other site
179408006176	Response regulator receiver domain; Region: Response_reg; pfam00072
179408006177	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408006178	active site
179408006179	phosphorylation site [posttranslational modification]
179408006180	intermolecular recognition site; other site
179408006181	dimerization interface [polypeptide binding]; other site
179408006182	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408006183	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408006184	metal binding site [ion binding]; metal-binding site
179408006185	active site
179408006186	I-site; other site
179408006187	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
179408006188	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408006189	putative active site [active]
179408006190	signal recognition particle protein; Provisional; Region: PRK10867
179408006191	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
179408006192	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
179408006193	GTP binding site [chemical binding]; other site
179408006194	Signal peptide binding domain; Region: SRP_SPB; pfam02978
179408006195	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408006196	putative active site [active]
179408006197	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408006198	GAF domain; Region: GAF; pfam01590
179408006199	Protein kinase domain; Region: Pkinase; pfam00069
179408006200	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408006201	active site
179408006202	ATP binding site [chemical binding]; other site
179408006203	substrate binding site [chemical binding]; other site
179408006204	activation loop (A-loop); other site
179408006205	AAA ATPase domain; Region: AAA_16; pfam13191
179408006206	Predicted ATPase [General function prediction only]; Region: COG3899
179408006207	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408006208	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408006209	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408006210	dimer interface [polypeptide binding]; other site
179408006211	phosphorylation site [posttranslational modification]
179408006212	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408006213	ATP binding site [chemical binding]; other site
179408006214	Mg2+ binding site [ion binding]; other site
179408006215	G-X-G motif; other site
179408006216	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
179408006217	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408006218	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006219	putative active site [active]
179408006220	heme pocket [chemical binding]; other site
179408006221	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006222	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408006223	putative active site [active]
179408006224	heme pocket [chemical binding]; other site
179408006225	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408006226	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006227	putative active site [active]
179408006228	heme pocket [chemical binding]; other site
179408006229	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006230	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408006231	putative active site [active]
179408006232	heme pocket [chemical binding]; other site
179408006233	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006234	putative active site [active]
179408006235	heme pocket [chemical binding]; other site
179408006236	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408006237	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
179408006238	dimer interface [polypeptide binding]; other site
179408006239	phosphorylation site [posttranslational modification]
179408006240	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408006241	ATP binding site [chemical binding]; other site
179408006242	Mg2+ binding site [ion binding]; other site
179408006243	G-X-G motif; other site
179408006244	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
179408006245	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
179408006246	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
179408006247	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
179408006248	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
179408006249	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
179408006250	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
179408006251	motif II; other site
179408006252	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
179408006253	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
179408006254	protein I interface; other site
179408006255	D2 interface; other site
179408006256	protein T interface; other site
179408006257	chlorophyll binding site; other site
179408006258	beta carotene binding site; other site
179408006259	pheophytin binding site; other site
179408006260	manganese-stabilizing polypeptide interface; other site
179408006261	CP43 interface; other site
179408006262	protein L interface; other site
179408006263	oxygen evolving complex binding site; other site
179408006264	bromide binding site; other site
179408006265	quinone binding site; other site
179408006266	Fe binding site [ion binding]; other site
179408006267	core light harvesting interface; other site
179408006268	cytochrome b559 alpha subunit interface; other site
179408006269	cytochrome c-550 interface; other site
179408006270	protein J interface; other site
179408006271	precorrin-3B synthase; Region: CobG; TIGR02435
179408006272	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
179408006273	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
179408006274	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
179408006275	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
179408006276	Precorrin-8X methylmutase; Region: CbiC; pfam02570
179408006277	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
179408006278	active site
179408006279	SAM binding site [chemical binding]; other site
179408006280	homodimer interface [polypeptide binding]; other site
179408006281	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
179408006282	protein I interface; other site
179408006283	D2 interface; other site
179408006284	protein T interface; other site
179408006285	chlorophyll binding site; other site
179408006286	beta carotene binding site; other site
179408006287	pheophytin binding site; other site
179408006288	manganese-stabilizing polypeptide interface; other site
179408006289	CP43 interface; other site
179408006290	protein L interface; other site
179408006291	oxygen evolving complex binding site; other site
179408006292	bromide binding site; other site
179408006293	quinone binding site; other site
179408006294	Fe binding site [ion binding]; other site
179408006295	core light harvesting interface; other site
179408006296	cytochrome b559 alpha subunit interface; other site
179408006297	cytochrome c-550 interface; other site
179408006298	protein J interface; other site
179408006299	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408006300	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
179408006301	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
179408006302	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
179408006303	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
179408006304	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
179408006305	motif II; other site
179408006306	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
179408006307	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408006308	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408006309	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
179408006310	putative active site [active]
179408006311	putative NTP binding site [chemical binding]; other site
179408006312	putative nucleic acid binding site [nucleotide binding]; other site
179408006313	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408006314	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408006315	active site
179408006316	Probable transposase; Region: OrfB_IS605; pfam01385
179408006317	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408006318	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
179408006319	Predicted permeases [General function prediction only]; Region: COG0701
179408006320	carotene isomerase; Region: carot_isom; TIGR02730
179408006321	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
179408006322	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
179408006323	Domain of unknown function (DUF814); Region: DUF814; pfam05670
179408006324	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
179408006325	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408006326	putative ADP-binding pocket [chemical binding]; other site
179408006327	Bacterial sugar transferase; Region: Bac_transf; pfam02397
179408006328	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
179408006329	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
179408006330	NADP-binding site; other site
179408006331	homotetramer interface [polypeptide binding]; other site
179408006332	substrate binding site [chemical binding]; other site
179408006333	homodimer interface [polypeptide binding]; other site
179408006334	active site
179408006335	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
179408006336	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
179408006337	NADP binding site [chemical binding]; other site
179408006338	active site
179408006339	putative substrate binding site [chemical binding]; other site
179408006340	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408006341	non-specific DNA binding site [nucleotide binding]; other site
179408006342	salt bridge; other site
179408006343	sequence-specific DNA binding site [nucleotide binding]; other site
179408006344	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
179408006345	Dynamin family; Region: Dynamin_N; pfam00350
179408006346	G1 box; other site
179408006347	GTP/Mg2+ binding site [chemical binding]; other site
179408006348	G2 box; other site
179408006349	Switch I region; other site
179408006350	Clusterin-associated protein-1; Region: Cluap1; pfam10234
179408006351	AAA ATPase domain; Region: AAA_16; pfam13191
179408006352	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
179408006353	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
179408006354	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
179408006355	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
179408006356	chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994
179408006357	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
179408006358	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
179408006359	dimer interface [polypeptide binding]; other site
179408006360	active site
179408006361	glycine-pyridoxal phosphate binding site [chemical binding]; other site
179408006362	folate binding site [chemical binding]; other site
179408006363	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
179408006364	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
179408006365	Mg++ binding site [ion binding]; other site
179408006366	putative catalytic motif [active]
179408006367	substrate binding site [chemical binding]; other site
179408006368	competence damage-inducible protein A; Provisional; Region: PRK00549
179408006369	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
179408006370	putative MPT binding site; other site
179408006371	Competence-damaged protein; Region: CinA; pfam02464
179408006372	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
179408006373	Dehydroquinase class II; Region: DHquinase_II; pfam01220
179408006374	trimer interface [polypeptide binding]; other site
179408006375	active site
179408006376	dimer interface [polypeptide binding]; other site
179408006377	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
179408006378	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
179408006379	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
179408006380	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
179408006381	Zn2+ binding site [ion binding]; other site
179408006382	Mg2+ binding site [ion binding]; other site
179408006383	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
179408006384	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408006385	dimer interface [polypeptide binding]; other site
179408006386	conserved gate region; other site
179408006387	putative PBP binding loops; other site
179408006388	ABC-ATPase subunit interface; other site
179408006389	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
179408006390	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
179408006391	heterotetramer interface [polypeptide binding]; other site
179408006392	active site pocket [active]
179408006393	cleavage site
179408006394	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408006395	Probable transposase; Region: OrfB_IS605; pfam01385
179408006396	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408006397	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
179408006398	HEAT repeats; Region: HEAT_2; pfam13646
179408006399	HEAT repeats; Region: HEAT_2; pfam13646
179408006400	HEAT repeats; Region: HEAT_2; pfam13646
179408006401	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
179408006402	nitrite reductase subunit NirD; Provisional; Region: PRK14989
179408006403	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
179408006404	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
179408006405	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
179408006406	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
179408006407	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
179408006408	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
179408006409	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
179408006410	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408006411	Walker A/P-loop; other site
179408006412	ATP binding site [chemical binding]; other site
179408006413	Q-loop/lid; other site
179408006414	ABC transporter signature motif; other site
179408006415	Walker B; other site
179408006416	D-loop; other site
179408006417	H-loop/switch region; other site
179408006418	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408006419	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
179408006420	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
179408006421	NADP binding site [chemical binding]; other site
179408006422	active site
179408006423	steroid binding site; other site
179408006424	EamA-like transporter family; Region: EamA; pfam00892
179408006425	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
179408006426	putative binding surface; other site
179408006427	active site
179408006428	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
179408006429	GAF domain; Region: GAF; pfam01590
179408006430	Phytochrome region; Region: PHY; pfam00360
179408006431	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408006432	ATP binding site [chemical binding]; other site
179408006433	Mg2+ binding site [ion binding]; other site
179408006434	G-X-G motif; other site
179408006435	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
179408006436	NADH(P)-binding; Region: NAD_binding_10; pfam13460
179408006437	NAD(P) binding site [chemical binding]; other site
179408006438	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
179408006439	NADH(P)-binding; Region: NAD_binding_10; pfam13460
179408006440	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
179408006441	active site
179408006442	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408006443	dimer interface [polypeptide binding]; other site
179408006444	conserved gate region; other site
179408006445	putative PBP binding loops; other site
179408006446	ABC-ATPase subunit interface; other site
179408006447	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
179408006448	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
179408006449	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
179408006450	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
179408006451	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408006452	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
179408006453	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408006454	dimer interface [polypeptide binding]; other site
179408006455	phosphorylation site [posttranslational modification]
179408006456	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408006457	ATP binding site [chemical binding]; other site
179408006458	Mg2+ binding site [ion binding]; other site
179408006459	G-X-G motif; other site
179408006460	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
179408006461	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408006462	active site
179408006463	phosphorylation site [posttranslational modification]
179408006464	intermolecular recognition site; other site
179408006465	dimerization interface [polypeptide binding]; other site
179408006466	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
179408006467	DNA binding site [nucleotide binding]
179408006468	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
179408006469	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
179408006470	ligand binding site [chemical binding]; other site
179408006471	flexible hinge region; other site
179408006472	TLC ATP/ADP transporter; Region: TLC; cl03940
179408006473	HEAT repeats; Region: HEAT_2; pfam13646
179408006474	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
179408006475	translation initiation factor 3; Provisional; Region: infC; CHL00199
179408006476	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
179408006477	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
179408006478	hydrolase, alpha/beta fold family protein; Region: PLN02824
179408006479	AMIN domain; Region: AMIN; pfam11741
179408006480	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
179408006481	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
179408006482	active site
179408006483	metal binding site [ion binding]; metal-binding site
179408006484	glutamate racemase; Provisional; Region: PRK00865
179408006485	YacP-like NYN domain; Region: NYN_YacP; cl01491
179408006486	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
179408006487	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
179408006488	DDE superfamily endonuclease; Region: DDE_4; pfam13359
179408006489	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408006490	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
179408006491	DXD motif; other site
179408006492	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
179408006493	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
179408006494	NAD(P) binding site [chemical binding]; other site
179408006495	active site
179408006496	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
179408006497	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
179408006498	Walker A motif; other site
179408006499	ATP binding site [chemical binding]; other site
179408006500	Walker B motif; other site
179408006501	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
179408006502	Protein of unknown function DUF58; Region: DUF58; pfam01882
179408006503	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
179408006504	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
179408006505	Cl- selectivity filter; other site
179408006506	Cl- binding residues [ion binding]; other site
179408006507	pore gating glutamate residue; other site
179408006508	dimer interface [polypeptide binding]; other site
179408006509	H+/Cl- coupling transport residue; other site
179408006510	FOG: CBS domain [General function prediction only]; Region: COG0517
179408006511	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
179408006512	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
179408006513	Ligand Binding Site [chemical binding]; other site
179408006514	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
179408006515	Ligand Binding Site [chemical binding]; other site
179408006516	cell division topological specificity factor MinE; Provisional; Region: PRK13988
179408006517	septum site-determining protein MinD; Region: minD_bact; TIGR01968
179408006518	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
179408006519	Switch I; other site
179408006520	Switch II; other site
179408006521	septum formation inhibitor; Reviewed; Region: minC; PRK00513
179408006522	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
179408006523	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
179408006524	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
179408006525	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
179408006526	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
179408006527	AAA ATPase domain; Region: AAA_16; pfam13191
179408006528	NACHT domain; Region: NACHT; pfam05729
179408006529	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
179408006530	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
179408006531	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
179408006532	Protein of unknown function (DUF1361); Region: DUF1361; pfam07099
179408006533	CHASE domain; Region: CHASE; cl01369
179408006534	PAS domain S-box; Region: sensory_box; TIGR00229
179408006535	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006536	putative active site [active]
179408006537	heme pocket [chemical binding]; other site
179408006538	PAS fold; Region: PAS_4; pfam08448
179408006539	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006540	putative active site [active]
179408006541	heme pocket [chemical binding]; other site
179408006542	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408006543	GAF domain; Region: GAF; pfam01590
179408006544	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006545	PAS fold; Region: PAS_3; pfam08447
179408006546	putative active site [active]
179408006547	heme pocket [chemical binding]; other site
179408006548	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408006549	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006550	putative active site [active]
179408006551	heme pocket [chemical binding]; other site
179408006552	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006553	putative active site [active]
179408006554	heme pocket [chemical binding]; other site
179408006555	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408006556	dimer interface [polypeptide binding]; other site
179408006557	phosphorylation site [posttranslational modification]
179408006558	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408006559	ATP binding site [chemical binding]; other site
179408006560	Mg2+ binding site [ion binding]; other site
179408006561	G-X-G motif; other site
179408006562	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
179408006563	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408006564	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408006565	active site
179408006566	phosphorylation site [posttranslational modification]
179408006567	intermolecular recognition site; other site
179408006568	dimerization interface [polypeptide binding]; other site
179408006569	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408006570	dimer interface [polypeptide binding]; other site
179408006571	phosphorylation site [posttranslational modification]
179408006572	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408006573	ATP binding site [chemical binding]; other site
179408006574	Mg2+ binding site [ion binding]; other site
179408006575	G-X-G motif; other site
179408006576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408006577	Response regulator receiver domain; Region: Response_reg; pfam00072
179408006578	active site
179408006579	phosphorylation site [posttranslational modification]
179408006580	intermolecular recognition site; other site
179408006581	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408006582	dimerization interface [polypeptide binding]; other site
179408006583	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408006584	ATP binding site [chemical binding]; other site
179408006585	Mg2+ binding site [ion binding]; other site
179408006586	G-X-G motif; other site
179408006587	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408006588	Response regulator receiver domain; Region: Response_reg; pfam00072
179408006589	active site
179408006590	phosphorylation site [posttranslational modification]
179408006591	intermolecular recognition site; other site
179408006592	dimerization interface [polypeptide binding]; other site
179408006593	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
179408006594	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
179408006595	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006596	putative active site [active]
179408006597	heme pocket [chemical binding]; other site
179408006598	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408006599	dimer interface [polypeptide binding]; other site
179408006600	phosphorylation site [posttranslational modification]
179408006601	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408006602	ATP binding site [chemical binding]; other site
179408006603	Mg2+ binding site [ion binding]; other site
179408006604	G-X-G motif; other site
179408006605	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
179408006606	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
179408006607	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
179408006608	catalytic residue [active]
179408006609	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
179408006610	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408006611	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
179408006612	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
179408006613	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
179408006614	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
179408006615	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
179408006616	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
179408006617	Walker A motif; other site
179408006618	ATP binding site [chemical binding]; other site
179408006619	Walker B motif; other site
179408006620	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
179408006621	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
179408006622	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
179408006623	Walker A motif; other site
179408006624	ATP binding site [chemical binding]; other site
179408006625	Walker B motif; other site
179408006626	GrpE; Region: GrpE; pfam01025
179408006627	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
179408006628	dimer interface [polypeptide binding]; other site
179408006629	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
179408006630	molecular chaperone DnaK; Provisional; Region: PRK13411
179408006631	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
179408006632	nucleotide binding site [chemical binding]; other site
179408006633	NEF interaction site [polypeptide binding]; other site
179408006634	SBD interface [polypeptide binding]; other site
179408006635	chaperone protein DnaJ; Provisional; Region: PRK14293
179408006636	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
179408006637	HSP70 interaction site [polypeptide binding]; other site
179408006638	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
179408006639	Zn binding sites [ion binding]; other site
179408006640	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
179408006641	dimer interface [polypeptide binding]; other site
179408006642	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
179408006643	CPxP  motif; other site
179408006644	Predicted GTPases [General function prediction only]; Region: COG1162
179408006645	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
179408006646	RNA binding site [nucleotide binding]; other site
179408006647	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
179408006648	GTPase/Zn-binding domain interface [polypeptide binding]; other site
179408006649	GTP/Mg2+ binding site [chemical binding]; other site
179408006650	G4 box; other site
179408006651	G5 box; other site
179408006652	G1 box; other site
179408006653	Switch I region; other site
179408006654	G2 box; other site
179408006655	G3 box; other site
179408006656	Switch II region; other site
179408006657	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
179408006658	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
179408006659	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
179408006660	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
179408006661	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
179408006662	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
179408006663	active site
179408006664	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408006665	Probable transposase; Region: OrfB_IS605; pfam01385
179408006666	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408006667	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
179408006668	ABC1 family; Region: ABC1; cl17513
179408006669	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408006670	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408006671	active site
179408006672	ATP binding site [chemical binding]; other site
179408006673	substrate binding site [chemical binding]; other site
179408006674	activation loop (A-loop); other site
179408006675	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
179408006676	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
179408006677	peptide binding site [polypeptide binding]; other site
179408006678	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
179408006679	active site
179408006680	AAA domain; Region: AAA_33; pfam13671
179408006681	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
179408006682	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408006683	dimer interface [polypeptide binding]; other site
179408006684	conserved gate region; other site
179408006685	putative PBP binding loops; other site
179408006686	ABC-ATPase subunit interface; other site
179408006687	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
179408006688	HlyD family secretion protein; Region: HlyD_3; pfam13437
179408006689	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
179408006690	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
179408006691	FtsX-like permease family; Region: FtsX; pfam02687
179408006692	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
179408006693	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
179408006694	FtsX-like permease family; Region: FtsX; pfam02687
179408006695	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408006696	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
179408006697	active site
179408006698	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
179408006699	phosphoenolpyruvate synthase; Validated; Region: PRK06241
179408006700	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
179408006701	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
179408006702	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
179408006703	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
179408006704	HD domain; Region: HD_5; pfam13487
179408006705	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408006706	Probable transposase; Region: OrfB_IS605; pfam01385
179408006707	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408006708	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408006709	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408006710	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408006711	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408006712	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408006713	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
179408006714	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
179408006715	chaperone protein DnaJ; Provisional; Region: PRK14299
179408006716	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
179408006717	HSP70 interaction site [polypeptide binding]; other site
179408006718	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
179408006719	substrate binding site [polypeptide binding]; other site
179408006720	dimer interface [polypeptide binding]; other site
179408006721	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
179408006722	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
179408006723	ligand binding site; other site
179408006724	oligomer interface; other site
179408006725	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
179408006726	dimer interface [polypeptide binding]; other site
179408006727	N-terminal domain interface [polypeptide binding]; other site
179408006728	sulfate 1 binding site; other site
179408006729	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
179408006730	active site
179408006731	homodimer interface [polypeptide binding]; other site
179408006732	catalytic site [active]
179408006733	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
179408006734	Fasciclin domain; Region: Fasciclin; pfam02469
179408006735	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
179408006736	histidinol-phosphate aminotransferase; Provisional; Region: PRK02610
179408006737	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
179408006738	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408006739	homodimer interface [polypeptide binding]; other site
179408006740	catalytic residue [active]
179408006741	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
179408006742	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
179408006743	nucleotide binding site [chemical binding]; other site
179408006744	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
179408006745	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
179408006746	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
179408006747	dimer interface [polypeptide binding]; other site
179408006748	RNA polymerase sigma factor; Provisional; Region: PRK12518
179408006749	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
179408006750	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
179408006751	DNA binding residues [nucleotide binding]
179408006752	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
179408006753	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
179408006754	Protein of unknown function DUF58; Region: DUF58; pfam01882
179408006755	MoxR-like ATPases [General function prediction only]; Region: COG0714
179408006756	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408006757	Walker A motif; other site
179408006758	ATP binding site [chemical binding]; other site
179408006759	Walker B motif; other site
179408006760	arginine finger; other site
179408006761	Opioid growth factor receptor (OGFr) conserved region; Region: OGFr_N; pfam04664
179408006762	glutathione reductase; Validated; Region: PRK06116
179408006763	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
179408006764	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
179408006765	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
179408006766	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
179408006767	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
179408006768	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
179408006769	Walker A/P-loop; other site
179408006770	ATP binding site [chemical binding]; other site
179408006771	Q-loop/lid; other site
179408006772	ABC transporter signature motif; other site
179408006773	Walker B; other site
179408006774	D-loop; other site
179408006775	H-loop/switch region; other site
179408006776	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408006777	Probable transposase; Region: OrfB_IS605; pfam01385
179408006778	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408006779	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
179408006780	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
179408006781	putative acyl-acceptor binding pocket; other site
179408006782	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
179408006783	nucleoside/Zn binding site; other site
179408006784	dimer interface [polypeptide binding]; other site
179408006785	catalytic motif [active]
179408006786	tellurium resistance terB-like protein; Region: terB_like; cd07177
179408006787	metal binding site [ion binding]; metal-binding site
179408006788	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
179408006789	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
179408006790	substrate binding site [chemical binding]; other site
179408006791	oxyanion hole (OAH) forming residues; other site
179408006792	trimer interface [polypeptide binding]; other site
179408006793	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408006794	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408006795	Probable transposase; Region: OrfB_IS605; pfam01385
179408006796	Sporulation related domain; Region: SPOR; cl10051
179408006797	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
179408006798	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
179408006799	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408006800	Probable transposase; Region: OrfB_IS605; pfam01385
179408006801	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408006802	Methyltransferase domain; Region: Methyltransf_26; pfam13659
179408006803	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
179408006804	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
179408006805	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
179408006806	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
179408006807	putative active site [active]
179408006808	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
179408006809	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
179408006810	active site
179408006811	dimer interface [polypeptide binding]; other site
179408006812	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
179408006813	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
179408006814	active site
179408006815	FMN binding site [chemical binding]; other site
179408006816	substrate binding site [chemical binding]; other site
179408006817	3Fe-4S cluster binding site [ion binding]; other site
179408006818	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
179408006819	domain interface; other site
179408006820	Transposase IS200 like; Region: Y1_Tnp; pfam01797
179408006821	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
179408006822	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408006823	active site
179408006824	ATP binding site [chemical binding]; other site
179408006825	substrate binding site [chemical binding]; other site
179408006826	activation loop (A-loop); other site
179408006827	AAA ATPase domain; Region: AAA_16; pfam13191
179408006828	Predicted ATPase [General function prediction only]; Region: COG3899
179408006829	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408006830	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408006831	PAS domain; Region: PAS_9; pfam13426
179408006832	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
179408006833	PAS fold; Region: PAS_4; pfam08448
179408006834	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006835	putative active site [active]
179408006836	heme pocket [chemical binding]; other site
179408006837	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
179408006838	Histidine kinase; Region: HisKA_3; pfam07730
179408006839	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408006840	ATP binding site [chemical binding]; other site
179408006841	Mg2+ binding site [ion binding]; other site
179408006842	G-X-G motif; other site
179408006843	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
179408006844	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408006845	active site
179408006846	phosphorylation site [posttranslational modification]
179408006847	intermolecular recognition site; other site
179408006848	dimerization interface [polypeptide binding]; other site
179408006849	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
179408006850	DNA binding residues [nucleotide binding]
179408006851	dimerization interface [polypeptide binding]; other site
179408006852	Cupin domain; Region: Cupin_2; pfam07883
179408006853	short chain dehydrogenase; Provisional; Region: PRK06500
179408006854	classical (c) SDRs; Region: SDR_c; cd05233
179408006855	NAD(P) binding site [chemical binding]; other site
179408006856	active site
179408006857	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
179408006858	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
179408006859	putative NAD(P) binding site [chemical binding]; other site
179408006860	choline dehydrogenase; Validated; Region: PRK02106
179408006861	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
179408006862	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
179408006863	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
179408006864	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
179408006865	SnoaL-like domain; Region: SnoaL_4; pfam13577
179408006866	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
179408006867	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
179408006868	NAD(P) binding site [chemical binding]; other site
179408006869	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
179408006870	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
179408006871	Isochorismatase family; Region: Isochorismatase; pfam00857
179408006872	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
179408006873	catalytic triad [active]
179408006874	conserved cis-peptide bond; other site
179408006875	mercuric reductase; Validated; Region: PRK06370
179408006876	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
179408006877	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
179408006878	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
179408006879	Thioredoxin; Region: Thioredoxin_4; cl17273
179408006880	short chain dehydrogenase; Provisional; Region: PRK08263
179408006881	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
179408006882	NADP binding site [chemical binding]; other site
179408006883	active site
179408006884	steroid binding site; other site
179408006885	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
179408006886	Epoxide hydrolase N terminus; Region: EHN; pfam06441
179408006887	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408006888	Probable transposase; Region: OrfB_IS605; pfam01385
179408006889	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408006890	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408006891	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408006892	active site
179408006893	phosphorylation site [posttranslational modification]
179408006894	intermolecular recognition site; other site
179408006895	dimerization interface [polypeptide binding]; other site
179408006896	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408006897	dimer interface [polypeptide binding]; other site
179408006898	phosphorylation site [posttranslational modification]
179408006899	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408006900	ATP binding site [chemical binding]; other site
179408006901	Mg2+ binding site [ion binding]; other site
179408006902	G-X-G motif; other site
179408006903	Protein kinase domain; Region: Pkinase; pfam00069
179408006904	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408006905	active site
179408006906	ATP binding site [chemical binding]; other site
179408006907	substrate binding site [chemical binding]; other site
179408006908	substrate binding site [chemical binding]; other site
179408006909	activation loop (A-loop); other site
179408006910	activation loop (A-loop); other site
179408006911	AAA ATPase domain; Region: AAA_16; pfam13191
179408006912	Predicted ATPase [General function prediction only]; Region: COG3899
179408006913	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408006914	GAF domain; Region: GAF; pfam01590
179408006915	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408006916	dimer interface [polypeptide binding]; other site
179408006917	phosphorylation site [posttranslational modification]
179408006918	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408006919	ATP binding site [chemical binding]; other site
179408006920	Mg2+ binding site [ion binding]; other site
179408006921	G-X-G motif; other site
179408006922	Response regulator receiver domain; Region: Response_reg; pfam00072
179408006923	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408006924	active site
179408006925	phosphorylation site [posttranslational modification]
179408006926	intermolecular recognition site; other site
179408006927	dimerization interface [polypeptide binding]; other site
179408006928	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
179408006929	putative catalytic site [active]
179408006930	putative metal binding site [ion binding]; other site
179408006931	putative phosphate binding site [ion binding]; other site
179408006932	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408006933	S-adenosylmethionine binding site [chemical binding]; other site
179408006934	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
179408006935	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
179408006936	putative dimer interface [polypeptide binding]; other site
179408006937	Winged helix-turn helix; Region: HTH_29; pfam13551
179408006938	Homeodomain-like domain; Region: HTH_32; pfam13565
179408006939	Winged helix-turn helix; Region: HTH_33; pfam13592
179408006940	DDE superfamily endonuclease; Region: DDE_3; pfam13358
179408006941	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
179408006942	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006943	PAS domain; Region: PAS_9; pfam13426
179408006944	putative active site [active]
179408006945	heme pocket [chemical binding]; other site
179408006946	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408006947	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006948	putative active site [active]
179408006949	heme pocket [chemical binding]; other site
179408006950	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408006951	putative active site [active]
179408006952	heme pocket [chemical binding]; other site
179408006953	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408006954	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408006955	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408006956	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408006957	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408006958	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408006959	dimer interface [polypeptide binding]; other site
179408006960	phosphorylation site [posttranslational modification]
179408006961	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408006962	ATP binding site [chemical binding]; other site
179408006963	Mg2+ binding site [ion binding]; other site
179408006964	G-X-G motif; other site
179408006965	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408006966	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408006967	active site
179408006968	phosphorylation site [posttranslational modification]
179408006969	intermolecular recognition site; other site
179408006970	dimerization interface [polypeptide binding]; other site
179408006971	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
179408006972	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
179408006973	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408006974	non-specific DNA binding site [nucleotide binding]; other site
179408006975	salt bridge; other site
179408006976	sequence-specific DNA binding site [nucleotide binding]; other site
179408006977	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
179408006978	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408006979	non-specific DNA binding site [nucleotide binding]; other site
179408006980	salt bridge; other site
179408006981	sequence-specific DNA binding site [nucleotide binding]; other site
179408006982	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408006983	non-specific DNA binding site [nucleotide binding]; other site
179408006984	salt bridge; other site
179408006985	sequence-specific DNA binding site [nucleotide binding]; other site
179408006986	hypothetical protein; Provisional; Region: PRK09256
179408006987	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
179408006988	Restriction endonuclease; Region: Mrr_cat; pfam04471
179408006989	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
179408006990	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
179408006991	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
179408006992	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408006993	putative active site [active]
179408006994	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
179408006995	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
179408006996	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408006997	Walker A/P-loop; other site
179408006998	ATP binding site [chemical binding]; other site
179408006999	Q-loop/lid; other site
179408007000	ABC transporter signature motif; other site
179408007001	Walker B; other site
179408007002	D-loop; other site
179408007003	H-loop/switch region; other site
179408007004	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408007005	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408007006	structural tetrad; other site
179408007007	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
179408007008	structural tetrad; other site
179408007009	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408007010	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408007011	structural tetrad; other site
179408007012	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408007013	putative active site [active]
179408007014	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
179408007015	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
179408007016	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
179408007017	trimer interface [polypeptide binding]; other site
179408007018	active site
179408007019	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
179408007020	catalytic site [active]
179408007021	Protein of unknown function (DUF3050); Region: DUF3050; pfam11251
179408007022	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
179408007023	Predicted ATPase [General function prediction only]; Region: COG4637
179408007024	P-loop containing region of AAA domain; Region: AAA_29; cl17516
179408007025	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
179408007026	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
179408007027	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
179408007028	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
179408007029	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
179408007030	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
179408007031	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
179408007032	Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304
179408007033	ligand binding site [chemical binding]; other site
179408007034	Cache domain; Region: Cache_1; pfam02743
179408007035	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408007036	dimerization interface [polypeptide binding]; other site
179408007037	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408007038	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408007039	putative active site [active]
179408007040	heme pocket [chemical binding]; other site
179408007041	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
179408007042	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408007043	putative active site [active]
179408007044	heme pocket [chemical binding]; other site
179408007045	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408007046	dimer interface [polypeptide binding]; other site
179408007047	phosphorylation site [posttranslational modification]
179408007048	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408007049	ATP binding site [chemical binding]; other site
179408007050	Mg2+ binding site [ion binding]; other site
179408007051	G-X-G motif; other site
179408007052	circadian clock protein KaiC; Reviewed; Region: PRK09302
179408007053	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
179408007054	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
179408007055	Walker A motif; other site
179408007056	Walker A motif; other site
179408007057	ATP binding site [chemical binding]; other site
179408007058	Walker B motif; other site
179408007059	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
179408007060	Walker A motif; other site
179408007061	ATP binding site [chemical binding]; other site
179408007062	Walker B motif; other site
179408007063	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
179408007064	tetramer interface [polypeptide binding]; other site
179408007065	dimer interface [polypeptide binding]; other site
179408007066	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
179408007067	tetramer interface [polypeptide binding]; other site
179408007068	dimer interface [polypeptide binding]; other site
179408007069	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408007070	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408007071	putative active site [active]
179408007072	heme pocket [chemical binding]; other site
179408007073	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408007074	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408007075	putative active site [active]
179408007076	heme pocket [chemical binding]; other site
179408007077	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
179408007078	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408007079	putative active site [active]
179408007080	heme pocket [chemical binding]; other site
179408007081	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408007082	dimer interface [polypeptide binding]; other site
179408007083	phosphorylation site [posttranslational modification]
179408007084	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408007085	ATP binding site [chemical binding]; other site
179408007086	Mg2+ binding site [ion binding]; other site
179408007087	G-X-G motif; other site
179408007088	Response regulator receiver domain; Region: Response_reg; pfam00072
179408007089	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408007090	active site
179408007091	phosphorylation site [posttranslational modification]
179408007092	intermolecular recognition site; other site
179408007093	dimerization interface [polypeptide binding]; other site
179408007094	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
179408007095	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
179408007096	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
179408007097	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
179408007098	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
179408007099	catalytic residues [active]
179408007100	Protein of unknown function (DUF2459); Region: DUF2459; pfam09601
179408007101	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
179408007102	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
179408007103	serpin-like protein; Provisional; Region: PHA02660
179408007104	SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049
179408007105	reactive center loop; other site
179408007106	Isochorismatase family; Region: Isochorismatase; pfam00857
179408007107	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
179408007108	catalytic triad [active]
179408007109	conserved cis-peptide bond; other site
179408007110	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
179408007111	Protein of unknown function (DUF952); Region: DUF952; cl01393
179408007112	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
179408007113	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
179408007114	active site
179408007115	NTP binding site [chemical binding]; other site
179408007116	metal binding triad [ion binding]; metal-binding site
179408007117	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
179408007118	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
179408007119	Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718
179408007120	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408007121	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408007122	active site
179408007123	ATP binding site [chemical binding]; other site
179408007124	substrate binding site [chemical binding]; other site
179408007125	activation loop (A-loop); other site
179408007126	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
179408007127	Glycoprotease family; Region: Peptidase_M22; pfam00814
179408007128	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408007129	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408007130	binding surface
179408007131	TPR motif; other site
179408007132	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408007133	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408007134	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408007135	binding surface
179408007136	TPR motif; other site
179408007137	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408007138	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408007139	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408007140	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408007141	binding surface
179408007142	TPR motif; other site
179408007143	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408007144	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408007145	binding surface
179408007146	TPR motif; other site
179408007147	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408007148	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408007149	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408007150	binding surface
179408007151	TPR motif; other site
179408007152	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408007153	CHAT domain; Region: CHAT; pfam12770
179408007154	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
179408007155	classical (c) SDRs; Region: SDR_c; cd05233
179408007156	NAD(P) binding site [chemical binding]; other site
179408007157	active site
179408007158	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
179408007159	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
179408007160	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
179408007161	dimer interface [polypeptide binding]; other site
179408007162	catalytic triad [active]
179408007163	Methyltransferase domain; Region: Methyltransf_31; pfam13847
179408007164	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408007165	S-adenosylmethionine binding site [chemical binding]; other site
179408007166	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
179408007167	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
179408007168	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
179408007169	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
179408007170	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
179408007171	D-pathway; other site
179408007172	Putative ubiquinol binding site [chemical binding]; other site
179408007173	Low-spin heme (heme b) binding site [chemical binding]; other site
179408007174	Putative water exit pathway; other site
179408007175	Binuclear center (heme o3/CuB) [ion binding]; other site
179408007176	K-pathway; other site
179408007177	Putative proton exit pathway; other site
179408007178	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
179408007179	Subunit I/III interface [polypeptide binding]; other site
179408007180	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
179408007181	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
179408007182	dimer interface [polypeptide binding]; other site
179408007183	[2Fe-2S] cluster binding site [ion binding]; other site
179408007184	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
179408007185	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
179408007186	dimer interface [polypeptide binding]; other site
179408007187	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408007188	catalytic residue [active]
179408007189	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408007190	putative active site [active]
179408007191	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408007192	putative active site [active]
179408007193	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
179408007194	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
179408007195	dimer interface [polypeptide binding]; other site
179408007196	decamer (pentamer of dimers) interface [polypeptide binding]; other site
179408007197	catalytic triad [active]
179408007198	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
179408007199	Protein of unknown function, DUF399; Region: DUF399; pfam04187
179408007200	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
179408007201	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408007202	Walker A/P-loop; other site
179408007203	ATP binding site [chemical binding]; other site
179408007204	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408007205	Q-loop/lid; other site
179408007206	ABC transporter signature motif; other site
179408007207	Walker B; other site
179408007208	D-loop; other site
179408007209	H-loop/switch region; other site
179408007210	TIGR02646 family protein; Region: TIGR02646
179408007211	Predicted flavoprotein [General function prediction only]; Region: COG0431
179408007212	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
179408007213	Helix-turn-helix domain; Region: HTH_17; cl17695
179408007214	PIN domain; Region: PIN_3; pfam13470
179408007215	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
179408007216	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
179408007217	active site
179408007218	PUCC protein; Region: PUCC; pfam03209
179408007219	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
179408007220	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
179408007221	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
179408007222	active site
179408007223	catalytic tetrad [active]
179408007224	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
179408007225	NB-ARC domain; Region: NB-ARC; pfam00931
179408007226	Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538
179408007227	Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776
179408007228	Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450
179408007229	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408007230	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408007231	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408007232	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408007233	TIGR03790 family protein; Region: TIGR03790
179408007234	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
179408007235	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
179408007236	Cl- selectivity filter; other site
179408007237	Cl- binding residues [ion binding]; other site
179408007238	pore gating glutamate residue; other site
179408007239	dimer interface [polypeptide binding]; other site
179408007240	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
179408007241	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
179408007242	FCP1-like phosphatase, phosphatase domain; Region: FCP1_euk; TIGR02250
179408007243	NLI interacting factor-like phosphatase; Region: NIF; pfam03031
179408007244	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
179408007245	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
179408007246	HSP70 interaction site [polypeptide binding]; other site
179408007247	Protein of unknown function (DUF3143); Region: DUF3143; pfam11341
179408007248	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
179408007249	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
179408007250	catalytic residue [active]
179408007251	putative FPP diphosphate  binding site; other site
179408007252	putative FPP binding hydrophobic cleft; other site
179408007253	dimer interface [polypeptide binding]; other site
179408007254	putative IPP diphosphate binding site; other site
179408007255	Uncharacterized conserved protein [Function unknown]; Region: COG1624
179408007256	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
179408007257	diaminopimelate decarboxylase; Region: lysA; TIGR01048
179408007258	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
179408007259	active site
179408007260	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
179408007261	substrate binding site [chemical binding]; other site
179408007262	catalytic residues [active]
179408007263	dimer interface [polypeptide binding]; other site
179408007264	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
179408007265	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
179408007266	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
179408007267	nucleophilic elbow; other site
179408007268	catalytic triad; other site
179408007269	Clp protease ATP binding subunit; Region: clpC; CHL00095
179408007270	Clp amino terminal domain; Region: Clp_N; pfam02861
179408007271	Clp amino terminal domain; Region: Clp_N; pfam02861
179408007272	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408007273	Walker A motif; other site
179408007274	ATP binding site [chemical binding]; other site
179408007275	Walker B motif; other site
179408007276	arginine finger; other site
179408007277	UvrB/uvrC motif; Region: UVR; pfam02151
179408007278	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408007279	Walker A motif; other site
179408007280	ATP binding site [chemical binding]; other site
179408007281	Walker B motif; other site
179408007282	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
179408007283	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
179408007284	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
179408007285	Catalytic site [active]
179408007286	Domain of unknown function (DUF1825); Region: DUF1825; pfam08855
179408007287	Transglycosylase; Region: Transgly; pfam00912
179408007288	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
179408007289	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
179408007290	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
179408007291	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
179408007292	active site
179408007293	HIGH motif; other site
179408007294	dimer interface [polypeptide binding]; other site
179408007295	KMSKS motif; other site
179408007296	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
179408007297	RNA binding surface [nucleotide binding]; other site
179408007298	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
179408007299	active site
179408007300	dimer interface [polypeptide binding]; other site
179408007301	Bpu10I restriction endonuclease; Region: RE_Bpu10I; pfam09549
179408007302	DNA methylase; Region: N6_N4_Mtase; cl17433
179408007303	Methyltransferase domain; Region: Methyltransf_26; pfam13659
179408007304	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
179408007305	Fe-S cluster binding site [ion binding]; other site
179408007306	active site
179408007307	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
179408007308	active site
179408007309	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
179408007310	active site
179408007311	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
179408007312	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
179408007313	catalytic core [active]
179408007314	TPR repeat; Region: TPR_11; pfam13414
179408007315	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408007316	binding surface
179408007317	TPR motif; other site
179408007318	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
179408007319	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
179408007320	active site
179408007321	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
179408007322	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
179408007323	Protein of unknown function (DUF433); Region: DUF433; pfam04255
179408007324	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
179408007325	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
179408007326	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
179408007327	generic binding surface II; other site
179408007328	generic binding surface I; other site
179408007329	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
179408007330	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
179408007331	catalytic site [active]
179408007332	G-X2-G-X-G-K; other site
179408007333	hypothetical protein; Provisional; Region: PRK04323
179408007334	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408007335	PAS domain; Region: PAS_9; pfam13426
179408007336	putative active site [active]
179408007337	heme pocket [chemical binding]; other site
179408007338	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408007339	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408007340	dimer interface [polypeptide binding]; other site
179408007341	phosphorylation site [posttranslational modification]
179408007342	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408007343	ATP binding site [chemical binding]; other site
179408007344	Mg2+ binding site [ion binding]; other site
179408007345	G-X-G motif; other site
179408007346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408007347	active site
179408007348	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
179408007349	phosphorylation site [posttranslational modification]
179408007350	intermolecular recognition site; other site
179408007351	dimerization interface [polypeptide binding]; other site
179408007352	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408007353	active site
179408007354	phosphorylation site [posttranslational modification]
179408007355	intermolecular recognition site; other site
179408007356	dimerization interface [polypeptide binding]; other site
179408007357	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408007358	metal binding site [ion binding]; metal-binding site
179408007359	active site
179408007360	I-site; other site
179408007361	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
179408007362	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408007363	S-adenosylmethionine binding site [chemical binding]; other site
179408007364	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
179408007365	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
179408007366	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
179408007367	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408007368	Walker A motif; other site
179408007369	ATP binding site [chemical binding]; other site
179408007370	Walker B motif; other site
179408007371	arginine finger; other site
179408007372	PAS fold; Region: PAS_4; pfam08448
179408007373	PAS domain S-box; Region: sensory_box; TIGR00229
179408007374	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408007375	putative active site [active]
179408007376	heme pocket [chemical binding]; other site
179408007377	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
179408007378	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408007379	dimer interface [polypeptide binding]; other site
179408007380	phosphorylation site [posttranslational modification]
179408007381	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408007382	ATP binding site [chemical binding]; other site
179408007383	Mg2+ binding site [ion binding]; other site
179408007384	G-X-G motif; other site
179408007385	uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792
179408007386	peptidase PmbA; Provisional; Region: PRK11040
179408007387	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
179408007388	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
179408007389	active site
179408007390	Zn binding site [ion binding]; other site
179408007391	Southampton virus-type processing peptidase; Region: Peptidase_C37; pfam05416
179408007392	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408007393	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408007394	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408007395	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408007396	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408007397	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408007398	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
179408007399	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
179408007400	Walker A/P-loop; other site
179408007401	ATP binding site [chemical binding]; other site
179408007402	Q-loop/lid; other site
179408007403	ABC transporter signature motif; other site
179408007404	Walker B; other site
179408007405	D-loop; other site
179408007406	H-loop/switch region; other site
179408007407	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
179408007408	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
179408007409	Walker A/P-loop; other site
179408007410	ATP binding site [chemical binding]; other site
179408007411	Q-loop/lid; other site
179408007412	ABC transporter signature motif; other site
179408007413	Walker B; other site
179408007414	D-loop; other site
179408007415	H-loop/switch region; other site
179408007416	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
179408007417	NMT1-like family; Region: NMT1_2; pfam13379
179408007418	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
179408007419	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408007420	dimer interface [polypeptide binding]; other site
179408007421	conserved gate region; other site
179408007422	ABC-ATPase subunit interface; other site
179408007423	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
179408007424	NMT1-like family; Region: NMT1_2; pfam13379
179408007425	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
179408007426	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
179408007427	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
179408007428	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
179408007429	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
179408007430	Soluble P-type ATPase [General function prediction only]; Region: COG4087
179408007431	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
179408007432	CHASE3 domain; Region: CHASE3; pfam05227
179408007433	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
179408007434	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
179408007435	dimer interface [polypeptide binding]; other site
179408007436	putative CheW interface [polypeptide binding]; other site
179408007437	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
179408007438	putative active site [active]
179408007439	Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335
179408007440	catalytic triad [active]
179408007441	conserved cis-peptide bond; other site
179408007442	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
179408007443	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
179408007444	mercuric reductase; Validated; Region: PRK06370
179408007445	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
179408007446	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
179408007447	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408007448	putative active site [active]
179408007449	polynucleotide kinase; Provisional; Region: pseT; PHA02530
179408007450	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
179408007451	active site
179408007452	RNA ligase; Region: RNA_lig_T4_1; pfam09511
179408007453	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
179408007454	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408007455	Probable transposase; Region: OrfB_IS605; pfam01385
179408007456	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408007457	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
179408007458	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
179408007459	catalytic residues [active]
179408007460	catalytic nucleophile [active]
179408007461	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
179408007462	putative active site [active]
179408007463	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
179408007464	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
179408007465	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
179408007466	domain interfaces; other site
179408007467	active site
179408007468	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
179408007469	PemK-like protein; Region: PemK; pfam02452
179408007470	Uncharacterized conserved protein [Function unknown]; Region: COG2442
179408007471	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
179408007472	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
179408007473	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
179408007474	Circadian oscillating protein COP23; Region: COP23; pfam14218
179408007475	glycogen synthase; Provisional; Region: glgA; PRK00654
179408007476	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
179408007477	ADP-binding pocket [chemical binding]; other site
179408007478	homodimer interface [polypeptide binding]; other site
179408007479	Domain of unknown function (DUF1824); Region: DUF1824; pfam08854
179408007480	ribonuclease III; Reviewed; Region: rnc; PRK00102
179408007481	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
179408007482	dimerization interface [polypeptide binding]; other site
179408007483	active site
179408007484	metal binding site [ion binding]; metal-binding site
179408007485	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
179408007486	dsRNA binding site [nucleotide binding]; other site
179408007487	ribonuclease III; Reviewed; Region: rnc; PRK00102
179408007488	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
179408007489	dimerization interface [polypeptide binding]; other site
179408007490	active site
179408007491	metal binding site [ion binding]; metal-binding site
179408007492	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
179408007493	dsRNA binding site [nucleotide binding]; other site
179408007494	UDP-sulfoquinovose:DAG sulfoquinovosyltransferase; Region: PLN02871
179408007495	light-harvesting-like protein 3; Provisional; Region: PLN00014
179408007496	Response regulator receiver domain; Region: Response_reg; pfam00072
179408007497	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408007498	active site
179408007499	phosphorylation site [posttranslational modification]
179408007500	intermolecular recognition site; other site
179408007501	dimerization interface [polypeptide binding]; other site
179408007502	PAS fold; Region: PAS_4; pfam08448
179408007503	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408007504	putative active site [active]
179408007505	heme pocket [chemical binding]; other site
179408007506	PAS domain S-box; Region: sensory_box; TIGR00229
179408007507	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408007508	putative active site [active]
179408007509	heme pocket [chemical binding]; other site
179408007510	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408007511	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
179408007512	putative active site [active]
179408007513	heme pocket [chemical binding]; other site
179408007514	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408007515	dimer interface [polypeptide binding]; other site
179408007516	phosphorylation site [posttranslational modification]
179408007517	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408007518	ATP binding site [chemical binding]; other site
179408007519	Mg2+ binding site [ion binding]; other site
179408007520	G-X-G motif; other site
179408007521	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
179408007522	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
179408007523	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
179408007524	putative active site [active]
179408007525	catalytic site [active]
179408007526	NifU-like domain; Region: NifU; pfam01106
179408007527	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
179408007528	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408007529	Probable transposase; Region: OrfB_IS605; pfam01385
179408007530	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
179408007531	PAS domain S-box; Region: sensory_box; TIGR00229
179408007532	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408007533	putative active site [active]
179408007534	heme pocket [chemical binding]; other site
179408007535	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408007536	PAS fold; Region: PAS_3; pfam08447
179408007537	putative active site [active]
179408007538	heme pocket [chemical binding]; other site
179408007539	PAS domain; Region: PAS_9; pfam13426
179408007540	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408007541	putative active site [active]
179408007542	heme pocket [chemical binding]; other site
179408007543	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408007544	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408007545	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408007546	dimer interface [polypeptide binding]; other site
179408007547	phosphorylation site [posttranslational modification]
179408007548	PAS fold; Region: PAS_4; pfam08448
179408007549	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408007550	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408007551	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408007552	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408007553	dimer interface [polypeptide binding]; other site
179408007554	phosphorylation site [posttranslational modification]
179408007555	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408007556	ATP binding site [chemical binding]; other site
179408007557	Mg2+ binding site [ion binding]; other site
179408007558	G-X-G motif; other site
179408007559	GTP-binding protein LepA; Provisional; Region: PRK05433
179408007560	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
179408007561	G1 box; other site
179408007562	putative GEF interaction site [polypeptide binding]; other site
179408007563	GTP/Mg2+ binding site [chemical binding]; other site
179408007564	Switch I region; other site
179408007565	G2 box; other site
179408007566	G3 box; other site
179408007567	Switch II region; other site
179408007568	G4 box; other site
179408007569	G5 box; other site
179408007570	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
179408007571	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
179408007572	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
179408007573	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
179408007574	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
179408007575	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408007576	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408007577	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408007578	active site
179408007579	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
179408007580	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
179408007581	NAD binding site [chemical binding]; other site
179408007582	putative substrate binding site 2 [chemical binding]; other site
179408007583	putative substrate binding site 1 [chemical binding]; other site
179408007584	active site
179408007585	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
179408007586	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
179408007587	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
179408007588	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
179408007589	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408007590	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
179408007591	non-specific DNA binding site [nucleotide binding]; other site
179408007592	salt bridge; other site
179408007593	sequence-specific DNA binding site [nucleotide binding]; other site
179408007594	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408007595	NACHT domain; Region: NACHT; pfam05729
179408007596	Walker A/P-loop; other site
179408007597	ATP binding site [chemical binding]; other site
179408007598	HEAT repeats; Region: HEAT_2; pfam13646
179408007599	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
179408007600	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408007601	putative active site [active]
179408007602	polyphosphate kinase; Provisional; Region: PRK05443
179408007603	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
179408007604	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
179408007605	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
179408007606	putative domain interface [polypeptide binding]; other site
179408007607	putative active site [active]
179408007608	catalytic site [active]
179408007609	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
179408007610	putative domain interface [polypeptide binding]; other site
179408007611	putative active site [active]
179408007612	catalytic site [active]
179408007613	Protein of unknown function (DUF2854); Region: DUF2854; pfam11016
179408007614	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
179408007615	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
179408007616	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
179408007617	putative NAD(P) binding site [chemical binding]; other site
179408007618	Protein of unknown function (DUF779); Region: DUF779; pfam05610
179408007619	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
179408007620	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
179408007621	NAD(P) binding site [chemical binding]; other site
179408007622	catalytic residues [active]
179408007623	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
179408007624	endonuclease III; Region: ENDO3c; smart00478
179408007625	minor groove reading motif; other site
179408007626	helix-hairpin-helix signature motif; other site
179408007627	substrate binding pocket [chemical binding]; other site
179408007628	active site
179408007629	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
179408007630	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
179408007631	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
179408007632	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
179408007633	metal-binding site [ion binding]
179408007634	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
179408007635	Soluble P-type ATPase [General function prediction only]; Region: COG4087
179408007636	Plastocyanin domain containing protein [General function prediction only]; Region: COG4633
179408007637	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
179408007638	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
179408007639	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
179408007640	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
179408007641	DNA binding residues [nucleotide binding]
179408007642	dimer interface [polypeptide binding]; other site
179408007643	Phytochelatin synthase; Region: Phytochelatin; pfam05023
179408007644	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408007645	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408007646	structural tetrad; other site
179408007647	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408007648	structural tetrad; other site
179408007649	CHAT domain; Region: CHAT; cl17868
179408007650	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
179408007651	cyclase homology domain; Region: CHD; cd07302
179408007652	nucleotidyl binding site; other site
179408007653	metal binding site [ion binding]; metal-binding site
179408007654	dimer interface [polypeptide binding]; other site
179408007655	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408007656	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408007657	active site
179408007658	ATP binding site [chemical binding]; other site
179408007659	substrate binding site [chemical binding]; other site
179408007660	activation loop (A-loop); other site
179408007661	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
179408007662	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
179408007663	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
179408007664	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
179408007665	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
179408007666	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
179408007667	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
179408007668	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
179408007669	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
179408007670	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
179408007671	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
179408007672	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
179408007673	AMP binding site [chemical binding]; other site
179408007674	metal binding site [ion binding]; metal-binding site
179408007675	active site
179408007676	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
179408007677	putative active site [active]
179408007678	transaldolase; Provisional; Region: PRK03903
179408007679	catalytic residue [active]
179408007680	integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752
179408007681	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
179408007682	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
179408007683	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
179408007684	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
179408007685	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408007686	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
179408007687	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
179408007688	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
179408007689	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
179408007690	catalytic triad [active]
179408007691	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
179408007692	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
179408007693	cytosine deaminase; Provisional; Region: PRK09230
179408007694	active site
179408007695	KGK domain; Region: KGK; pfam08872
179408007696	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
179408007697	amidase; Provisional; Region: PRK09201
179408007698	Amidase; Region: Amidase; pfam01425
179408007699	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
179408007700	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408007701	Radical SAM superfamily; Region: Radical_SAM; pfam04055
179408007702	FeS/SAM binding site; other site
179408007703	TPR repeat; Region: TPR_11; pfam13414
179408007704	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408007705	TPR motif; other site
179408007706	binding surface
179408007707	TPR repeat; Region: TPR_11; pfam13414
179408007708	TPR repeat; Region: TPR_11; pfam13414
179408007709	Tetratricopeptide repeat; Region: TPR_17; pfam13431
179408007710	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
179408007711	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408007712	magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031
179408007713	Walker A motif; other site
179408007714	ATP binding site [chemical binding]; other site
179408007715	Walker B motif; other site
179408007716	arginine finger; other site
179408007717	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
179408007718	metal ion-dependent adhesion site (MIDAS); other site
179408007719	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
179408007720	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408007721	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408007722	dimer interface [polypeptide binding]; other site
179408007723	phosphorylation site [posttranslational modification]
179408007724	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408007725	ATP binding site [chemical binding]; other site
179408007726	Mg2+ binding site [ion binding]; other site
179408007727	G-X-G motif; other site
179408007728	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
179408007729	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
179408007730	transmembrane helices; other site
179408007731	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
179408007732	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408007733	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408007734	dimer interface [polypeptide binding]; other site
179408007735	phosphorylation site [posttranslational modification]
179408007736	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408007737	ATP binding site [chemical binding]; other site
179408007738	Mg2+ binding site [ion binding]; other site
179408007739	G-X-G motif; other site
179408007740	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
179408007741	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408007742	dimer interface [polypeptide binding]; other site
179408007743	conserved gate region; other site
179408007744	putative PBP binding loops; other site
179408007745	ABC-ATPase subunit interface; other site
179408007746	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
179408007747	NMT1-like family; Region: NMT1_2; pfam13379
179408007748	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
179408007749	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
179408007750	Walker A/P-loop; other site
179408007751	ATP binding site [chemical binding]; other site
179408007752	Q-loop/lid; other site
179408007753	ABC transporter signature motif; other site
179408007754	Walker B; other site
179408007755	D-loop; other site
179408007756	H-loop/switch region; other site
179408007757	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
179408007758	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
179408007759	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
179408007760	active site
179408007761	dimerization interface [polypeptide binding]; other site
179408007762	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
179408007763	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
179408007764	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
179408007765	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408007766	non-specific DNA binding site [nucleotide binding]; other site
179408007767	salt bridge; other site
179408007768	sequence-specific DNA binding site [nucleotide binding]; other site
179408007769	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
179408007770	DNA methylase; Region: N6_N4_Mtase; pfam01555
179408007771	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
179408007772	MutS domain III; Region: MutS_III; pfam05192
179408007773	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408007774	Walker A/P-loop; other site
179408007775	ATP binding site [chemical binding]; other site
179408007776	Q-loop/lid; other site
179408007777	ABC transporter signature motif; other site
179408007778	Walker B; other site
179408007779	D-loop; other site
179408007780	H-loop/switch region; other site
179408007781	Smr domain; Region: Smr; pfam01713
179408007782	Response regulator receiver domain; Region: Response_reg; pfam00072
179408007783	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408007784	active site
179408007785	phosphorylation site [posttranslational modification]
179408007786	intermolecular recognition site; other site
179408007787	dimerization interface [polypeptide binding]; other site
179408007788	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408007789	dimer interface [polypeptide binding]; other site
179408007790	phosphorylation site [posttranslational modification]
179408007791	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408007792	ATP binding site [chemical binding]; other site
179408007793	Mg2+ binding site [ion binding]; other site
179408007794	G-X-G motif; other site
179408007795	homoserine kinase; Provisional; Region: PRK01212
179408007796	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
179408007797	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408007798	putative active site [active]
179408007799	TPR repeat; Region: TPR_11; pfam13414
179408007800	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408007801	binding surface
179408007802	TPR motif; other site
179408007803	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408007804	putative active site [active]
179408007805	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
179408007806	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
179408007807	metal ion-dependent adhesion site (MIDAS); other site
179408007808	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
179408007809	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
179408007810	oligomer interface [polypeptide binding]; other site
179408007811	active site residues [active]
179408007812	Clp protease; Region: CLP_protease; pfam00574
179408007813	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
179408007814	oligomer interface [polypeptide binding]; other site
179408007815	active site residues [active]
179408007816	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
179408007817	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
179408007818	HSP70 interaction site [polypeptide binding]; other site
179408007819	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408007820	active site
179408007821	ATP binding site [chemical binding]; other site
179408007822	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
179408007823	substrate binding site [chemical binding]; other site
179408007824	activation loop (A-loop); other site
179408007825	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
179408007826	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
179408007827	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
179408007828	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
179408007829	conserved hypothetical protein; Region: TIGR03492
179408007830	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408007831	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408007832	active site
179408007833	phosphorylation site [posttranslational modification]
179408007834	intermolecular recognition site; other site
179408007835	dimerization interface [polypeptide binding]; other site
179408007836	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408007837	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408007838	putative active site [active]
179408007839	heme pocket [chemical binding]; other site
179408007840	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408007841	putative active site [active]
179408007842	heme pocket [chemical binding]; other site
179408007843	PAS domain S-box; Region: sensory_box; TIGR00229
179408007844	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408007845	putative active site [active]
179408007846	heme pocket [chemical binding]; other site
179408007847	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408007848	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408007849	putative active site [active]
179408007850	heme pocket [chemical binding]; other site
179408007851	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408007852	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408007853	putative active site [active]
179408007854	heme pocket [chemical binding]; other site
179408007855	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408007856	putative active site [active]
179408007857	heme pocket [chemical binding]; other site
179408007858	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408007859	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408007860	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408007861	dimer interface [polypeptide binding]; other site
179408007862	phosphorylation site [posttranslational modification]
179408007863	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408007864	ATP binding site [chemical binding]; other site
179408007865	Mg2+ binding site [ion binding]; other site
179408007866	G-X-G motif; other site
179408007867	Response regulator receiver domain; Region: Response_reg; pfam00072
179408007868	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408007869	active site
179408007870	phosphorylation site [posttranslational modification]
179408007871	intermolecular recognition site; other site
179408007872	dimerization interface [polypeptide binding]; other site
179408007873	Response regulator receiver domain; Region: Response_reg; pfam00072
179408007874	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408007875	active site
179408007876	phosphorylation site [posttranslational modification]
179408007877	intermolecular recognition site; other site
179408007878	dimerization interface [polypeptide binding]; other site
179408007879	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408007880	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408007881	dimer interface [polypeptide binding]; other site
179408007882	phosphorylation site [posttranslational modification]
179408007883	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408007884	ATP binding site [chemical binding]; other site
179408007885	Mg2+ binding site [ion binding]; other site
179408007886	G-X-G motif; other site
179408007887	TPR repeat; Region: TPR_11; pfam13414
179408007888	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408007889	binding surface
179408007890	TPR motif; other site
179408007891	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
179408007892	Tetratricopeptide repeat; Region: TPR_1; pfam00515
179408007893	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408007894	binding surface
179408007895	TPR motif; other site
179408007896	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408007897	binding surface
179408007898	TPR motif; other site
179408007899	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408007900	binding surface
179408007901	TPR motif; other site
179408007902	TPR repeat; Region: TPR_11; pfam13414
179408007903	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408007904	binding surface
179408007905	TPR motif; other site
179408007906	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
179408007907	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408007908	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408007909	active site
179408007910	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
179408007911	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408007912	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408007913	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408007914	active site
179408007915	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408007916	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408007917	active site
179408007918	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408007919	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
179408007920	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
179408007921	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
179408007922	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
179408007923	substrate binding site; other site
179408007924	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
179408007925	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
179408007926	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
179408007927	Domain of unknown function (DUF1995); Region: DUF1995; pfam09353
179408007928	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
179408007929	active site
179408007930	metal binding site [ion binding]; metal-binding site
179408007931	Peptidase family M48; Region: Peptidase_M48; pfam01435
179408007932	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
179408007933	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
179408007934	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
179408007935	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
179408007936	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
179408007937	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
179408007938	Riboflavin kinase; Region: Flavokinase; pfam01687
179408007939	MoxR-like ATPases [General function prediction only]; Region: COG0714
179408007940	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408007941	Walker A motif; other site
179408007942	ATP binding site [chemical binding]; other site
179408007943	Walker B motif; other site
179408007944	arginine finger; other site
179408007945	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
179408007946	putative ADP-binding pocket [chemical binding]; other site
179408007947	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408007948	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408007949	non-specific DNA binding site [nucleotide binding]; other site
179408007950	salt bridge; other site
179408007951	sequence-specific DNA binding site [nucleotide binding]; other site
179408007952	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
179408007953	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
179408007954	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
179408007955	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09742
179408007956	CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558
179408007957	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
179408007958	CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577
179408007959	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
179408007960	Protein of unknown function (DUF2488); Region: Ycf54; pfam10674
179408007961	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408007962	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408007963	active site
179408007964	ATP binding site [chemical binding]; other site
179408007965	substrate binding site [chemical binding]; other site
179408007966	activation loop (A-loop); other site
179408007967	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
179408007968	TPR repeat; Region: TPR_11; pfam13414
179408007969	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408007970	binding surface
179408007971	TPR motif; other site
179408007972	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
179408007973	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408007974	binding surface
179408007975	TPR motif; other site
179408007976	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408007977	binding surface
179408007978	TPR motif; other site
179408007979	Tetratricopeptide repeat; Region: TPR_16; pfam13432
179408007980	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
179408007981	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
179408007982	putative NAD(P) binding site [chemical binding]; other site
179408007983	active site
179408007984	DNA primase; Validated; Region: dnaG; PRK05667
179408007985	CHC2 zinc finger; Region: zf-CHC2; pfam01807
179408007986	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
179408007987	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
179408007988	active site
179408007989	metal binding site [ion binding]; metal-binding site
179408007990	interdomain interaction site; other site
179408007991	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408007992	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408007993	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408007994	hypothetical protein; Reviewed; Region: PRK12497
179408007995	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
179408007996	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
179408007997	ribosomal protein L32; Validated; Region: rpl32; CHL00152
179408007998	TM2 domain; Region: TM2; pfam05154
179408007999	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
179408008000	diiron binding motif [ion binding]; other site
179408008001	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408008002	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408008003	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408008004	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408008005	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408008006	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408008007	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408008008	TPR repeat; Region: TPR_11; pfam13414
179408008009	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408008010	binding surface
179408008011	TPR motif; other site
179408008012	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408008013	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408008014	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408008015	binding surface
179408008016	TPR motif; other site
179408008017	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408008018	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408008019	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408008020	binding surface
179408008021	TPR motif; other site
179408008022	CHAT domain; Region: CHAT; pfam12770
179408008023	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
179408008024	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408008025	S-adenosylmethionine binding site [chemical binding]; other site
179408008026	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
179408008027	putative active site [active]
179408008028	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
179408008029	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
179408008030	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
179408008031	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
179408008032	DNA polymerase III subunit alpha; Reviewed; Region: PRK09532
179408008033	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
179408008034	active site
179408008035	PHP Thumb interface [polypeptide binding]; other site
179408008036	metal binding site [ion binding]; metal-binding site
179408008037	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
179408008038	protein-splicing catalytic site; other site
179408008039	thioester formation/cholesterol transfer; other site
179408008040	reverse gyrase; Provisional; Region: PRK14701
179408008041	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
179408008042	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
179408008043	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
179408008044	generic binding surface I; other site
179408008045	generic binding surface II; other site
179408008046	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
179408008047	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408008048	active site
179408008049	ATP binding site [chemical binding]; other site
179408008050	substrate binding site [chemical binding]; other site
179408008051	activation loop (A-loop); other site
179408008052	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408008053	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408008054	structural tetrad; other site
179408008055	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
179408008056	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
179408008057	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
179408008058	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
179408008059	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408008060	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408008061	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408008062	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408008063	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408008064	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
179408008065	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
179408008066	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
179408008067	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
179408008068	Homeodomain-like domain; Region: HTH_23; pfam13384
179408008069	Winged helix-turn helix; Region: HTH_29; pfam13551
179408008070	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
179408008071	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
179408008072	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
179408008073	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
179408008074	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
179408008075	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
179408008076	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
179408008077	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
179408008078	active site
179408008079	metal binding site [ion binding]; metal-binding site
179408008080	dimerization interface [polypeptide binding]; other site
179408008081	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
179408008082	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
179408008083	anti sigma factor interaction site; other site
179408008084	regulatory phosphorylation site [posttranslational modification]; other site
179408008085	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
179408008086	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
179408008087	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
179408008088	catalytic site [active]
179408008089	subunit interface [polypeptide binding]; other site
179408008090	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
179408008091	catalytic motif [active]
179408008092	Catalytic residue [active]
179408008093	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
179408008094	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
179408008095	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
179408008096	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408008097	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008098	putative active site [active]
179408008099	heme pocket [chemical binding]; other site
179408008100	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008101	putative active site [active]
179408008102	heme pocket [chemical binding]; other site
179408008103	PAS domain S-box; Region: sensory_box; TIGR00229
179408008104	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008105	putative active site [active]
179408008106	heme pocket [chemical binding]; other site
179408008107	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008108	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408008109	putative active site [active]
179408008110	heme pocket [chemical binding]; other site
179408008111	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008112	putative active site [active]
179408008113	heme pocket [chemical binding]; other site
179408008114	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408008115	ATP binding site [chemical binding]; other site
179408008116	Mg2+ binding site [ion binding]; other site
179408008117	G-X-G motif; other site
179408008118	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
179408008119	Mechanosensitive ion channel; Region: MS_channel; pfam00924
179408008120	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
179408008121	RNA/DNA hybrid binding site [nucleotide binding]; other site
179408008122	active site
179408008123	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
179408008124	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
179408008125	homodimer interface [polypeptide binding]; other site
179408008126	oligonucleotide binding site [chemical binding]; other site
179408008127	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
179408008128	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408008129	FeS/SAM binding site; other site
179408008130	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
179408008131	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
179408008132	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
179408008133	anti sigma factor interaction site; other site
179408008134	regulatory phosphorylation site [posttranslational modification]; other site
179408008135	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408008136	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408008137	active site
179408008138	phosphorylation site [posttranslational modification]
179408008139	intermolecular recognition site; other site
179408008140	dimerization interface [polypeptide binding]; other site
179408008141	PAS domain S-box; Region: sensory_box; TIGR00229
179408008142	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008143	putative active site [active]
179408008144	heme pocket [chemical binding]; other site
179408008145	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008146	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408008147	putative active site [active]
179408008148	heme pocket [chemical binding]; other site
179408008149	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008150	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
179408008151	putative active site [active]
179408008152	heme pocket [chemical binding]; other site
179408008153	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408008154	dimer interface [polypeptide binding]; other site
179408008155	phosphorylation site [posttranslational modification]
179408008156	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408008157	ATP binding site [chemical binding]; other site
179408008158	Mg2+ binding site [ion binding]; other site
179408008159	G-X-G motif; other site
179408008160	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408008161	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408008162	active site
179408008163	phosphorylation site [posttranslational modification]
179408008164	intermolecular recognition site; other site
179408008165	dimerization interface [polypeptide binding]; other site
179408008166	Uncharacterized conserved protein [Function unknown]; Region: COG2928
179408008167	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408008168	Probable transposase; Region: OrfB_IS605; pfam01385
179408008169	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408008170	transcription antitermination protein NusB; Provisional; Region: nusB; PRK09634
179408008171	putative RNA binding site [nucleotide binding]; other site
179408008172	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
179408008173	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
179408008174	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
179408008175	P loop; other site
179408008176	GTP binding site [chemical binding]; other site
179408008177	GAF domain; Region: GAF_3; pfam13492
179408008178	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
179408008179	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
179408008180	argininosuccinate lyase; Provisional; Region: PRK00855
179408008181	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
179408008182	active sites [active]
179408008183	tetramer interface [polypeptide binding]; other site
179408008184	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
179408008185	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
179408008186	catalytic triad [active]
179408008187	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
179408008188	nudix motif; other site
179408008189	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
179408008190	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
179408008191	pantothenate kinase; Reviewed; Region: PRK13331
179408008192	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408008193	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408008194	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408008195	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408008196	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408008197	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408008198	ATP binding site [chemical binding]; other site
179408008199	Mg2+ binding site [ion binding]; other site
179408008200	G-X-G motif; other site
179408008201	Calx-beta domain; Region: Calx-beta; pfam03160
179408008202	Calx-beta domain; Region: Calx-beta; pfam03160
179408008203	Calx-beta domain; Region: Calx-beta; cl02522
179408008204	Calx-beta domain; Region: Calx-beta; cl02522
179408008205	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
179408008206	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
179408008207	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
179408008208	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
179408008209	metal ion-dependent adhesion site (MIDAS); other site
179408008210	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
179408008211	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
179408008212	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
179408008213	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
179408008214	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
179408008215	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
179408008216	Bacterial sugar transferase; Region: Bac_transf; pfam02397
179408008217	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
179408008218	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
179408008219	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
179408008220	ligand binding site [chemical binding]; other site
179408008221	flexible hinge region; other site
179408008222	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
179408008223	putative switch regulator; other site
179408008224	non-specific DNA interactions [nucleotide binding]; other site
179408008225	DNA binding site [nucleotide binding]
179408008226	sequence specific DNA binding site [nucleotide binding]; other site
179408008227	putative cAMP binding site [chemical binding]; other site
179408008228	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
179408008229	Ligand Binding Site [chemical binding]; other site
179408008230	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
179408008231	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
179408008232	putative dimer interface [polypeptide binding]; other site
179408008233	active site pocket [active]
179408008234	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
179408008235	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
179408008236	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
179408008237	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008238	putative active site [active]
179408008239	heme pocket [chemical binding]; other site
179408008240	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408008241	dimer interface [polypeptide binding]; other site
179408008242	phosphorylation site [posttranslational modification]
179408008243	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408008244	ATP binding site [chemical binding]; other site
179408008245	Mg2+ binding site [ion binding]; other site
179408008246	G-X-G motif; other site
179408008247	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408008248	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
179408008249	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408008250	putative active site [active]
179408008251	putative NTP binding site [chemical binding]; other site
179408008252	putative nucleic acid binding site [nucleotide binding]; other site
179408008253	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408008254	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408008255	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408008256	active site
179408008257	PAS fold; Region: PAS_4; pfam08448
179408008258	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008259	putative active site [active]
179408008260	heme pocket [chemical binding]; other site
179408008261	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
179408008262	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
179408008263	active site
179408008264	catalytic tetrad [active]
179408008265	Bifunctional nuclease; Region: DNase-RNase; pfam02577
179408008266	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
179408008267	Lumazine binding domain; Region: Lum_binding; pfam00677
179408008268	Lumazine binding domain; Region: Lum_binding; pfam00677
179408008269	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408008270	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
179408008271	active site
179408008272	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
179408008273	Peptidase family M23; Region: Peptidase_M23; pfam01551
179408008274	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408008275	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408008276	Probable transposase; Region: OrfB_IS605; pfam01385
179408008277	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
179408008278	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
179408008279	Protein of unknown function (DUF3353); Region: DUF3353; pfam11833
179408008280	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
179408008281	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
179408008282	motif II; other site
179408008283	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008284	PAS domain; Region: PAS_9; pfam13426
179408008285	putative active site [active]
179408008286	heme pocket [chemical binding]; other site
179408008287	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408008288	GAF domain; Region: GAF_2; pfam13185
179408008289	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408008290	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408008291	metal binding site [ion binding]; metal-binding site
179408008292	active site
179408008293	I-site; other site
179408008294	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
179408008295	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408008296	Coenzyme A binding pocket [chemical binding]; other site
179408008297	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
179408008298	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
179408008299	dimer interface [polypeptide binding]; other site
179408008300	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
179408008301	active site
179408008302	Fe binding site [ion binding]; other site
179408008303	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
179408008304	classical (c) SDRs; Region: SDR_c; cd05233
179408008305	NAD(P) binding site [chemical binding]; other site
179408008306	active site
179408008307	LabA_like proteins; Region: LabA_like; cd06167
179408008308	putative metal binding site [ion binding]; other site
179408008309	Amino acid permease; Region: AA_permease; pfam00324
179408008310	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
179408008311	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
179408008312	Walker A/P-loop; other site
179408008313	ATP binding site [chemical binding]; other site
179408008314	Q-loop/lid; other site
179408008315	ABC transporter signature motif; other site
179408008316	Walker B; other site
179408008317	D-loop; other site
179408008318	H-loop/switch region; other site
179408008319	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
179408008320	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408008321	dimer interface [polypeptide binding]; other site
179408008322	conserved gate region; other site
179408008323	putative PBP binding loops; other site
179408008324	ABC-ATPase subunit interface; other site
179408008325	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
179408008326	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408008327	dimer interface [polypeptide binding]; other site
179408008328	conserved gate region; other site
179408008329	putative PBP binding loops; other site
179408008330	ABC-ATPase subunit interface; other site
179408008331	PBP superfamily domain; Region: PBP_like_2; cl17296
179408008332	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
179408008333	InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811
179408008334	LabA_like proteins; Region: LabA_like; cd06167
179408008335	putative metal binding site [ion binding]; other site
179408008336	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
179408008337	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408008338	non-specific DNA binding site [nucleotide binding]; other site
179408008339	salt bridge; other site
179408008340	sequence-specific DNA binding site [nucleotide binding]; other site
179408008341	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408008342	non-specific DNA binding site [nucleotide binding]; other site
179408008343	salt bridge; other site
179408008344	sequence-specific DNA binding site [nucleotide binding]; other site
179408008345	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408008346	non-specific DNA binding site [nucleotide binding]; other site
179408008347	salt bridge; other site
179408008348	sequence-specific DNA binding site [nucleotide binding]; other site
179408008349	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
179408008350	Protein of unknown function (DUF4058); Region: DUF4058; pfam13267
179408008351	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
179408008352	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
179408008353	Walker A/P-loop; other site
179408008354	ATP binding site [chemical binding]; other site
179408008355	Q-loop/lid; other site
179408008356	ABC transporter signature motif; other site
179408008357	Walker B; other site
179408008358	D-loop; other site
179408008359	H-loop/switch region; other site
179408008360	hypothetical protein; Provisional; Region: PRK13683
179408008361	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
179408008362	D1 interface; other site
179408008363	chlorophyll binding site; other site
179408008364	pheophytin binding site; other site
179408008365	beta carotene binding site; other site
179408008366	cytochrome b559 beta interface; other site
179408008367	quinone binding site; other site
179408008368	cytochrome b559 alpha interface; other site
179408008369	protein J interface; other site
179408008370	protein H interface; other site
179408008371	protein X interface; other site
179408008372	core light harvesting protein interface; other site
179408008373	protein L interface; other site
179408008374	CP43 interface; other site
179408008375	protein T interface; other site
179408008376	Fe binding site [ion binding]; other site
179408008377	protein M interface; other site
179408008378	Mn-stabilizing polypeptide interface; other site
179408008379	bromide binding site; other site
179408008380	cytochrome c-550 interface; other site
179408008381	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408008382	Probable transposase; Region: OrfB_IS605; pfam01385
179408008383	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408008384	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
179408008385	aromatic arch; other site
179408008386	DCoH dimer interaction site [polypeptide binding]; other site
179408008387	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
179408008388	DCoH tetramer interaction site [polypeptide binding]; other site
179408008389	substrate binding site [chemical binding]; other site
179408008390	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408008391	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408008392	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
179408008393	Zn2+ binding site [ion binding]; other site
179408008394	Mg2+ binding site [ion binding]; other site
179408008395	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
179408008396	S-layer homology domain; Region: SLH; pfam00395
179408008397	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
179408008398	Predicted transcriptional regulator [Transcription]; Region: COG1959
179408008399	Transcriptional regulator; Region: Rrf2; pfam02082
179408008400	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
179408008401	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
179408008402	dimer interface [polypeptide binding]; other site
179408008403	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408008404	catalytic residue [active]
179408008405	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
179408008406	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
179408008407	HSP70 interaction site [polypeptide binding]; other site
179408008408	Mechanosensitive ion channel; Region: MS_channel; pfam00924
179408008409	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
179408008410	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
179408008411	ligand binding site [chemical binding]; other site
179408008412	flexible hinge region; other site
179408008413	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
179408008414	active site
179408008415	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
179408008416	active site
179408008417	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
179408008418	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408008419	binding surface
179408008420	TPR motif; other site
179408008421	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
179408008422	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408008423	binding surface
179408008424	TPR motif; other site
179408008425	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408008426	binding surface
179408008427	TPR motif; other site
179408008428	TPR repeat; Region: TPR_11; pfam13414
179408008429	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408008430	putative active site [active]
179408008431	Putative restriction endonuclease; Region: Uma2; pfam05685
179408008432	putative active site [active]
179408008433	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
179408008434	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
179408008435	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408008436	putative active site [active]
179408008437	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
179408008438	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
179408008439	cofactor binding site; other site
179408008440	DNA binding site [nucleotide binding]
179408008441	substrate interaction site [chemical binding]; other site
179408008442	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
179408008443	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
179408008444	active site
179408008445	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408008446	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408008447	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408008448	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408008449	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408008450	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408008451	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408008452	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
179408008453	putative hexamer interface [polypeptide binding]; other site
179408008454	putative hexagonal pore; other site
179408008455	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
179408008456	Hexamer interface [polypeptide binding]; other site
179408008457	Hexagonal pore residue; other site
179408008458	GAF domain; Region: GAF_3; pfam13492
179408008459	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408008460	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008461	putative active site [active]
179408008462	PAS fold; Region: PAS_3; pfam08447
179408008463	heme pocket [chemical binding]; other site
179408008464	PAS fold; Region: PAS_3; pfam08447
179408008465	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008466	heme pocket [chemical binding]; other site
179408008467	putative active site [active]
179408008468	PAS fold; Region: PAS_4; pfam08448
179408008469	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408008470	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008471	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408008472	putative active site [active]
179408008473	heme pocket [chemical binding]; other site
179408008474	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008475	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408008476	putative active site [active]
179408008477	heme pocket [chemical binding]; other site
179408008478	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008479	putative active site [active]
179408008480	heme pocket [chemical binding]; other site
179408008481	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408008482	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408008483	PAS domain; Region: PAS_9; pfam13426
179408008484	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008485	putative active site [active]
179408008486	heme pocket [chemical binding]; other site
179408008487	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408008488	dimer interface [polypeptide binding]; other site
179408008489	phosphorylation site [posttranslational modification]
179408008490	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408008491	ATP binding site [chemical binding]; other site
179408008492	Mg2+ binding site [ion binding]; other site
179408008493	G-X-G motif; other site
179408008494	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408008495	active site
179408008496	phosphorylation site [posttranslational modification]
179408008497	intermolecular recognition site; other site
179408008498	dimerization interface [polypeptide binding]; other site
179408008499	Creatinine amidohydrolase; Region: Creatininase; pfam02633
179408008500	Protein of unknown function (DUF561); Region: DUF561; pfam04481
179408008501	Calcium binding; Region: Calci_bind_CcbP; pfam11535
179408008502	Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; pfam10063
179408008503	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
179408008504	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
179408008505	DNA protecting protein DprA; Region: dprA; TIGR00732
179408008506	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
179408008507	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
179408008508	Family description; Region: VCBS; pfam13517
179408008509	Family description; Region: VCBS; pfam13517
179408008510	Family description; Region: VCBS; pfam13517
179408008511	Family description; Region: VCBS; pfam13517
179408008512	Family description; Region: VCBS; pfam13517
179408008513	Calx-beta domain; Region: Calx-beta; cl02522
179408008514	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
179408008515	catalytic triad [active]
179408008516	putative active site [active]
179408008517	Family description; Region: VCBS; pfam13517
179408008518	Family description; Region: VCBS; pfam13517
179408008519	Family description; Region: VCBS; pfam13517
179408008520	Family description; Region: VCBS; pfam13517
179408008521	Family description; Region: VCBS; pfam13517
179408008522	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
179408008523	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408008524	DltD N-terminal region; Region: DltD_N; pfam04915
179408008525	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
179408008526	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
179408008527	active site
179408008528	Cupin-like domain; Region: Cupin_8; pfam13621
179408008529	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
179408008530	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
179408008531	substrate binding site [chemical binding]; other site
179408008532	ATP binding site [chemical binding]; other site
179408008533	Predicted methyltransferases [General function prediction only]; Region: COG0313
179408008534	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
179408008535	putative SAM binding site [chemical binding]; other site
179408008536	putative homodimer interface [polypeptide binding]; other site
179408008537	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408008538	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
179408008539	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
179408008540	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
179408008541	cofactor binding site; other site
179408008542	DNA binding site [nucleotide binding]
179408008543	substrate interaction site [chemical binding]; other site
179408008544	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
179408008545	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
179408008546	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408008547	putative active site [active]
179408008548	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
179408008549	putative active site [active]
179408008550	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
179408008551	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
179408008552	Competence protein A; Region: Competence_A; pfam11104
179408008553	Cell division protein FtsA; Region: FtsA; cl17206
179408008554	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
179408008555	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
179408008556	AMIN domain; Region: AMIN; pfam11741
179408008557	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
179408008558	Secretin and TonB N terminus short domain; Region: STN; pfam07660
179408008559	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
179408008560	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
179408008561	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
179408008562	IHF dimer interface [polypeptide binding]; other site
179408008563	IHF - DNA interface [nucleotide binding]; other site
179408008564	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
179408008565	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
179408008566	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408008567	homodimer interface [polypeptide binding]; other site
179408008568	catalytic residue [active]
179408008569	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
179408008570	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
179408008571	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
179408008572	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
179408008573	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408008574	active site
179408008575	ATP binding site [chemical binding]; other site
179408008576	substrate binding site [chemical binding]; other site
179408008577	activation loop (A-loop); other site
179408008578	AAA ATPase domain; Region: AAA_16; pfam13191
179408008579	Predicted ATPase [General function prediction only]; Region: COG3899
179408008580	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408008581	GAF domain; Region: GAF; pfam01590
179408008582	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408008583	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408008584	dimer interface [polypeptide binding]; other site
179408008585	phosphorylation site [posttranslational modification]
179408008586	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408008587	ATP binding site [chemical binding]; other site
179408008588	Mg2+ binding site [ion binding]; other site
179408008589	G-X-G motif; other site
179408008590	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
179408008591	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
179408008592	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
179408008593	Nucleoside recognition; Region: Gate; pfam07670
179408008594	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
179408008595	haemagglutination activity domain; Region: Haemagg_act; pfam05860
179408008596	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
179408008597	CHAT domain; Region: CHAT; cl17868
179408008598	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408008599	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408008600	active site
179408008601	ATP binding site [chemical binding]; other site
179408008602	substrate binding site [chemical binding]; other site
179408008603	activation loop (A-loop); other site
179408008604	AAA ATPase domain; Region: AAA_16; pfam13191
179408008605	Predicted ATPase [General function prediction only]; Region: COG3899
179408008606	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408008607	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408008608	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408008609	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408008610	ATP binding site [chemical binding]; other site
179408008611	Mg2+ binding site [ion binding]; other site
179408008612	G-X-G motif; other site
179408008613	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408008614	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408008615	dimer interface [polypeptide binding]; other site
179408008616	phosphorylation site [posttranslational modification]
179408008617	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408008618	ATP binding site [chemical binding]; other site
179408008619	Mg2+ binding site [ion binding]; other site
179408008620	G-X-G motif; other site
179408008621	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408008622	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408008623	GAF domain; Region: GAF; pfam01590
179408008624	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408008625	dimer interface [polypeptide binding]; other site
179408008626	phosphorylation site [posttranslational modification]
179408008627	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408008628	ATP binding site [chemical binding]; other site
179408008629	Mg2+ binding site [ion binding]; other site
179408008630	G-X-G motif; other site
179408008631	Protein of unknown function (DUF3155); Region: DUF3155; pfam11352
179408008632	Protein of unknown function (DUF3529); Region: DUF3529; pfam12046
179408008633	Predicted transcriptional regulators [Transcription]; Region: COG1695
179408008634	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
179408008635	Protein of unknown function (DUF751); Region: DUF751; pfam05421
179408008636	DNA adenine methylase (dam); Region: dam; TIGR00571
179408008637	Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378
179408008638	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
179408008639	active site
179408008640	metal binding site [ion binding]; metal-binding site
179408008641	Uncharacterized conserved protein [Function unknown]; Region: COG3391
179408008642	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
179408008643	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
179408008644	active site
179408008645	substrate binding site [chemical binding]; other site
179408008646	Mg2+ binding site [ion binding]; other site
179408008647	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408008648	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408008649	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408008650	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408008651	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408008652	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408008653	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408008654	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
179408008655	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
179408008656	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
179408008657	Predicted membrane protein [Function unknown]; Region: COG1950
179408008658	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
179408008659	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
179408008660	putative active site cavity [active]
179408008661	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408008662	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408008663	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408008664	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408008665	dimer interface [polypeptide binding]; other site
179408008666	phosphorylation site [posttranslational modification]
179408008667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408008668	ATP binding site [chemical binding]; other site
179408008669	Mg2+ binding site [ion binding]; other site
179408008670	G-X-G motif; other site
179408008671	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408008672	Response regulator receiver domain; Region: Response_reg; pfam00072
179408008673	active site
179408008674	phosphorylation site [posttranslational modification]
179408008675	intermolecular recognition site; other site
179408008676	dimerization interface [polypeptide binding]; other site
179408008677	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
179408008678	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
179408008679	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408008680	active site
179408008681	phosphorylation site [posttranslational modification]
179408008682	intermolecular recognition site; other site
179408008683	dimerization interface [polypeptide binding]; other site
179408008684	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
179408008685	DNA binding site [nucleotide binding]
179408008686	Hpt domain; Region: Hpt; pfam01627
179408008687	putative binding surface; other site
179408008688	active site
179408008689	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408008690	Response regulator receiver domain; Region: Response_reg; pfam00072
179408008691	active site
179408008692	phosphorylation site [posttranslational modification]
179408008693	intermolecular recognition site; other site
179408008694	dimerization interface [polypeptide binding]; other site
179408008695	Response regulator receiver domain; Region: Response_reg; pfam00072
179408008696	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408008697	active site
179408008698	phosphorylation site [posttranslational modification]
179408008699	intermolecular recognition site; other site
179408008700	dimerization interface [polypeptide binding]; other site
179408008701	PAS fold; Region: PAS_2; pfam08446
179408008702	GAF domain; Region: GAF; pfam01590
179408008703	Phytochrome region; Region: PHY; pfam00360
179408008704	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008705	PAS fold; Region: PAS_3; pfam08447
179408008706	putative active site [active]
179408008707	heme pocket [chemical binding]; other site
179408008708	PAS domain; Region: PAS_9; pfam13426
179408008709	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008710	putative active site [active]
179408008711	heme pocket [chemical binding]; other site
179408008712	PAS domain S-box; Region: sensory_box; TIGR00229
179408008713	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008714	putative active site [active]
179408008715	heme pocket [chemical binding]; other site
179408008716	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408008717	dimer interface [polypeptide binding]; other site
179408008718	phosphorylation site [posttranslational modification]
179408008719	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408008720	ATP binding site [chemical binding]; other site
179408008721	Mg2+ binding site [ion binding]; other site
179408008722	G-X-G motif; other site
179408008723	Response regulator receiver domain; Region: Response_reg; pfam00072
179408008724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408008725	active site
179408008726	phosphorylation site [posttranslational modification]
179408008727	intermolecular recognition site; other site
179408008728	dimerization interface [polypeptide binding]; other site
179408008729	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
179408008730	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
179408008731	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
179408008732	active site
179408008733	motif I; other site
179408008734	motif II; other site
179408008735	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
179408008736	S-layer homology domain; Region: SLH; pfam00395
179408008737	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
179408008738	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008739	PAS domain; Region: PAS_9; pfam13426
179408008740	putative active site [active]
179408008741	heme pocket [chemical binding]; other site
179408008742	PAS domain S-box; Region: sensory_box; TIGR00229
179408008743	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008744	putative active site [active]
179408008745	heme pocket [chemical binding]; other site
179408008746	PAS fold; Region: PAS_4; pfam08448
179408008747	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008748	putative active site [active]
179408008749	heme pocket [chemical binding]; other site
179408008750	PAS domain S-box; Region: sensory_box; TIGR00229
179408008751	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008752	putative active site [active]
179408008753	heme pocket [chemical binding]; other site
179408008754	PAS domain S-box; Region: sensory_box; TIGR00229
179408008755	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408008756	putative active site [active]
179408008757	heme pocket [chemical binding]; other site
179408008758	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408008759	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408008760	dimer interface [polypeptide binding]; other site
179408008761	phosphorylation site [posttranslational modification]
179408008762	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408008763	ATP binding site [chemical binding]; other site
179408008764	Mg2+ binding site [ion binding]; other site
179408008765	G-X-G motif; other site
179408008766	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
179408008767	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
179408008768	motif II; other site
179408008769	Putative restriction endonuclease; Region: Uma2; pfam05685
179408008770	aspartate kinase; Provisional; Region: PRK07431
179408008771	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
179408008772	putative catalytic residues [active]
179408008773	putative nucleotide binding site [chemical binding]; other site
179408008774	putative aspartate binding site [chemical binding]; other site
179408008775	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
179408008776	putative allosteric regulatory site; other site
179408008777	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
179408008778	putative allosteric regulatory residue; other site
179408008779	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
179408008780	putative allosteric regulatory site; other site
179408008781	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
179408008782	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
179408008783	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
179408008784	cofactor binding site; other site
179408008785	DNA binding site [nucleotide binding]
179408008786	substrate interaction site [chemical binding]; other site
179408008787	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
179408008788	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
179408008789	Repair protein; Region: Repair_PSII; pfam04536
179408008790	Predicted flavoprotein [General function prediction only]; Region: COG0431
179408008791	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
179408008792	cell division protein; Validated; Region: ftsH; CHL00176
179408008793	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408008794	Walker A motif; other site
179408008795	ATP binding site [chemical binding]; other site
179408008796	Walker B motif; other site
179408008797	arginine finger; other site
179408008798	Peptidase family M41; Region: Peptidase_M41; pfam01434
179408008799	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
179408008800	Peptidase family M23; Region: Peptidase_M23; pfam01551
179408008801	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
179408008802	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
179408008803	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
179408008804	ATP binding site [chemical binding]; other site
179408008805	putative Mg++ binding site [ion binding]; other site
179408008806	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
179408008807	nucleotide binding region [chemical binding]; other site
179408008808	ATP-binding site [chemical binding]; other site
179408008809	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
179408008810	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
179408008811	RNA binding surface [nucleotide binding]; other site
179408008812	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
179408008813	active site
179408008814	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
179408008815	CpeS-like protein; Region: CpeS; pfam09367
179408008816	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
179408008817	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
179408008818	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
179408008819	Walker A/P-loop; other site
179408008820	ATP binding site [chemical binding]; other site
179408008821	Q-loop/lid; other site
179408008822	ABC transporter signature motif; other site
179408008823	Walker B; other site
179408008824	D-loop; other site
179408008825	H-loop/switch region; other site
179408008826	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
179408008827	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408008828	dimer interface [polypeptide binding]; other site
179408008829	conserved gate region; other site
179408008830	putative PBP binding loops; other site
179408008831	ABC-ATPase subunit interface; other site
179408008832	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
179408008833	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408008834	dimer interface [polypeptide binding]; other site
179408008835	conserved gate region; other site
179408008836	putative PBP binding loops; other site
179408008837	ABC-ATPase subunit interface; other site
179408008838	PBP superfamily domain; Region: PBP_like_2; cl17296
179408008839	BioY family; Region: BioY; pfam02632
179408008840	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
179408008841	lipoprotein signal peptidase; Provisional; Region: PRK14787
179408008842	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
179408008843	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
179408008844	B12 binding site [chemical binding]; other site
179408008845	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408008846	FeS/SAM binding site; other site
179408008847	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
179408008848	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
179408008849	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
179408008850	putative hydrophobic ligand binding site [chemical binding]; other site
179408008851	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
179408008852	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
179408008853	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
179408008854	catalytic triad [active]
179408008855	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
179408008856	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
179408008857	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
179408008858	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
179408008859	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
179408008860	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
179408008861	active site
179408008862	catalytic tetrad [active]
179408008863	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
179408008864	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
179408008865	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
179408008866	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
179408008867	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
179408008868	hypothetical protein; Provisional; Region: PRK07377
179408008869	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567
179408008870	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408008871	putative active site [active]
179408008872	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408008873	S-adenosylmethionine binding site [chemical binding]; other site
179408008874	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
179408008875	putative active site [active]
179408008876	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
179408008877	YcfA-like protein; Region: YcfA; pfam07927
179408008878	NADH dehydrogenase subunit J; Provisional; Region: PRK12494
179408008879	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
179408008880	NADH dehydrogenase subunit K; Region: ndhK; CHL00023
179408008881	NADH dehydrogenase subunit 3; Region: ndhC; CHL00022
179408008882	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
179408008883	Rubredoxin; Region: Rubredoxin; pfam00301
179408008884	iron binding site [ion binding]; other site
179408008885	Ycf48-like protein; Provisional; Region: PRK13684
179408008886	cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557
179408008887	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283
179408008888	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284
179408008889	cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561
179408008890	PsbL protein; Region: PsbL; cl03581
179408008891	PsbJ; Region: PsbJ; pfam01788
179408008892	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
179408008893	phosphopeptide binding site; other site
179408008894	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
179408008895	Transglycosylase; Region: Transgly; pfam00912
179408008896	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
179408008897	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408008898	Probable transposase; Region: OrfB_IS605; pfam01385
179408008899	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
179408008900	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408008901	HAMP domain; Region: HAMP; pfam00672
179408008902	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408008903	dimer interface [polypeptide binding]; other site
179408008904	phosphorylation site [posttranslational modification]
179408008905	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408008906	ATP binding site [chemical binding]; other site
179408008907	Mg2+ binding site [ion binding]; other site
179408008908	G-X-G motif; other site
179408008909	Response regulator receiver domain; Region: Response_reg; pfam00072
179408008910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408008911	active site
179408008912	phosphorylation site [posttranslational modification]
179408008913	intermolecular recognition site; other site
179408008914	dimerization interface [polypeptide binding]; other site
179408008915	Response regulator receiver domain; Region: Response_reg; pfam00072
179408008916	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408008917	active site
179408008918	phosphorylation site [posttranslational modification]
179408008919	intermolecular recognition site; other site
179408008920	dimerization interface [polypeptide binding]; other site
179408008921	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
179408008922	Histidine kinase; Region: HisKA_3; pfam07730
179408008923	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408008924	ATP binding site [chemical binding]; other site
179408008925	Mg2+ binding site [ion binding]; other site
179408008926	G-X-G motif; other site
179408008927	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
179408008928	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408008929	active site
179408008930	phosphorylation site [posttranslational modification]
179408008931	intermolecular recognition site; other site
179408008932	dimerization interface [polypeptide binding]; other site
179408008933	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
179408008934	DNA binding residues [nucleotide binding]
179408008935	dimerization interface [polypeptide binding]; other site
179408008936	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408008937	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
179408008938	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
179408008939	active site
179408008940	SAM binding site [chemical binding]; other site
179408008941	homodimer interface [polypeptide binding]; other site
179408008942	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
179408008943	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
179408008944	putative active site [active]
179408008945	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
179408008946	putative active site [active]
179408008947	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
179408008948	Ferritin-like domain; Region: Ferritin; pfam00210
179408008949	dimanganese center [ion binding]; other site
179408008950	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
179408008951	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408008952	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408008953	active site
179408008954	ATP binding site [chemical binding]; other site
179408008955	substrate binding site [chemical binding]; other site
179408008956	activation loop (A-loop); other site
179408008957	GUN4-like; Region: GUN4; pfam05419
179408008958	AAA domain; Region: AAA_11; pfam13086
179408008959	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408008960	Walker A motif; other site
179408008961	ATP binding site [chemical binding]; other site
179408008962	Walker B motif; other site
179408008963	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
179408008964	AAA domain; Region: AAA_12; pfam13087
179408008965	XisH protein; Region: XisH; pfam08814
179408008966	XisI protein; Region: XisI; pfam08869
179408008967	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812
179408008968	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
179408008969	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
179408008970	active site
179408008971	Yqey-like protein; Region: YqeY; pfam09424
179408008972	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408008973	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408008974	active site
179408008975	ATP binding site [chemical binding]; other site
179408008976	substrate binding site [chemical binding]; other site
179408008977	activation loop (A-loop); other site
179408008978	AAA domain; Region: AAA_26; pfam13500
179408008979	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
179408008980	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
179408008981	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
179408008982	metal binding site [ion binding]; metal-binding site
179408008983	dimer interface [polypeptide binding]; other site
179408008984	Transposase [DNA replication, recombination, and repair]; Region: COG5421
179408008985	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
179408008986	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
179408008987	FtsX-like permease family; Region: FtsX; pfam02687
179408008988	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
179408008989	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
179408008990	HlyD family secretion protein; Region: HlyD_3; pfam13437
179408008991	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
179408008992	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
179408008993	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
179408008994	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
179408008995	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
179408008996	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
179408008997	Hemerythrin-like domain; Region: Hr-like; cd12108
179408008998	short chain dehydrogenase; Provisional; Region: PRK06701
179408008999	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
179408009000	NAD binding site [chemical binding]; other site
179408009001	metal binding site [ion binding]; metal-binding site
179408009002	active site
179408009003	Cna protein B-type domain; Region: Cna_B; pfam05738
179408009004	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
179408009005	Cna protein B-type domain; Region: Cna_B; pfam05738
179408009006	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
179408009007	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
179408009008	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
179408009009	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
179408009010	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408009011	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408009012	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
179408009013	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
179408009014	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
179408009015	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
179408009016	thiamine phosphate binding site [chemical binding]; other site
179408009017	active site
179408009018	pyrophosphate binding site [ion binding]; other site
179408009019	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
179408009020	thiS-thiF/thiG interaction site; other site
179408009021	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
179408009022	ribosomal protein L21; Region: rpl21; CHL00075
179408009023	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408009024	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408009025	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408009026	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408009027	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
179408009028	Protein of unknown function (DUF3122); Region: DUF3122; pfam11320
179408009029	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
179408009030	Cytochrome c; Region: Cytochrom_C; cl11414
179408009031	glycerol kinase; Provisional; Region: glpK; PRK00047
179408009032	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
179408009033	N- and C-terminal domain interface [polypeptide binding]; other site
179408009034	active site
179408009035	MgATP binding site [chemical binding]; other site
179408009036	catalytic site [active]
179408009037	metal binding site [ion binding]; metal-binding site
179408009038	putative homotetramer interface [polypeptide binding]; other site
179408009039	glycerol binding site [chemical binding]; other site
179408009040	homodimer interface [polypeptide binding]; other site
179408009041	Protein of unknown function DUF99; Region: DUF99; pfam01949
179408009042	hypothetical protein; Provisional; Region: PRK00766
179408009043	Phycobilisome protein; Region: Phycobilisome; cl08227
179408009044	Phycobilisome protein; Region: Phycobilisome; cl08227
179408009045	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
179408009046	EamA-like transporter family; Region: EamA; cl17759
179408009047	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
179408009048	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
179408009049	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
179408009050	non-specific DNA interactions [nucleotide binding]; other site
179408009051	DNA binding site [nucleotide binding]
179408009052	sequence specific DNA binding site [nucleotide binding]; other site
179408009053	putative cAMP binding site [chemical binding]; other site
179408009054	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
179408009055	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
179408009056	dimerization interface [polypeptide binding]; other site
179408009057	domain crossover interface; other site
179408009058	redox-dependent activation switch; other site
179408009059	Uncharacterized conserved protein [Function unknown]; Region: COG4021
179408009060	tRNAHis guanylyltransferase; Region: Thg1; pfam04446
179408009061	Thg1 C terminal domain; Region: Thg1C; pfam14413
179408009062	AAA domain; Region: AAA_33; pfam13671
179408009063	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476
179408009064	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
179408009065	tellurium resistance terB-like protein; Region: terB_like; cd07177
179408009066	metal binding site [ion binding]; metal-binding site
179408009067	Uncharacterized conserved protein [Function unknown]; Region: COG3339
179408009068	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
179408009069	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
179408009070	putative NAD(P) binding site [chemical binding]; other site
179408009071	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408009072	putative active site [active]
179408009073	Methyltransferase domain; Region: Methyltransf_31; pfam13847
179408009074	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408009075	S-adenosylmethionine binding site [chemical binding]; other site
179408009076	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
179408009077	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
179408009078	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
179408009079	catalytic residue [active]
179408009080	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
179408009081	FeS assembly protein SufD; Region: sufD; TIGR01981
179408009082	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
179408009083	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
179408009084	Walker A/P-loop; other site
179408009085	ATP binding site [chemical binding]; other site
179408009086	Q-loop/lid; other site
179408009087	ABC transporter signature motif; other site
179408009088	Walker B; other site
179408009089	D-loop; other site
179408009090	H-loop/switch region; other site
179408009091	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
179408009092	putative ABC transporter; Region: ycf24; CHL00085
179408009093	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
179408009094	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
179408009095	putative DNA binding site [nucleotide binding]; other site
179408009096	putative Zn2+ binding site [ion binding]; other site
179408009097	6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131
179408009098	PIN domain; Region: PIN; pfam01850
179408009099	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
179408009100	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
179408009101	GTP/Mg2+ binding site [chemical binding]; other site
179408009102	G4 box; other site
179408009103	G5 box; other site
179408009104	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
179408009105	G1 box; other site
179408009106	G1 box; other site
179408009107	GTP/Mg2+ binding site [chemical binding]; other site
179408009108	G2 box; other site
179408009109	Switch I region; other site
179408009110	G3 box; other site
179408009111	Switch II region; other site
179408009112	G4 box; other site
179408009113	G5 box; other site
179408009114	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
179408009115	putative active site [active]
179408009116	Protein of unknown function (DUF2281); Region: DUF2281; pfam10047
179408009117	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428
179408009118	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
179408009119	dimerization interface [polypeptide binding]; other site
179408009120	active site
179408009121	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408009122	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
179408009123	putative active site [active]
179408009124	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
179408009125	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
179408009126	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
179408009127	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
179408009128	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
179408009129	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408009130	dimer interface [polypeptide binding]; other site
179408009131	conserved gate region; other site
179408009132	ABC-ATPase subunit interface; other site
179408009133	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
179408009134	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408009135	S-adenosylmethionine binding site [chemical binding]; other site
179408009136	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
179408009137	Ycf35; Provisional; Region: ycf35; CHL00193
179408009138	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
179408009139	yiaA/B two helix domain; Region: YiaAB; cl01759
179408009140	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
179408009141	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
179408009142	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408009143	non-specific DNA binding site [nucleotide binding]; other site
179408009144	salt bridge; other site
179408009145	sequence-specific DNA binding site [nucleotide binding]; other site
179408009146	Domain of unknown function (DUF955); Region: DUF955; pfam06114
179408009147	ATP-grasp domain; Region: ATP-grasp_4; cl17255
179408009148	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
179408009149	arginine-tRNA ligase; Region: PLN02286
179408009150	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
179408009151	active site
179408009152	HIGH motif; other site
179408009153	KMSK motif region; other site
179408009154	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
179408009155	tRNA binding surface [nucleotide binding]; other site
179408009156	anticodon binding site; other site
179408009157	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
179408009158	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
179408009159	Malic enzyme, N-terminal domain; Region: malic; pfam00390
179408009160	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
179408009161	putative NAD(P) binding site [chemical binding]; other site
179408009162	PAS domain S-box; Region: sensory_box; TIGR00229
179408009163	PAS domain; Region: PAS; smart00091
179408009164	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408009165	PAS domain; Region: PAS_9; pfam13426
179408009166	putative active site [active]
179408009167	heme pocket [chemical binding]; other site
179408009168	PAS fold; Region: PAS_4; pfam08448
179408009169	PAS fold; Region: PAS_4; pfam08448
179408009170	PAS domain S-box; Region: sensory_box; TIGR00229
179408009171	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408009172	putative active site [active]
179408009173	heme pocket [chemical binding]; other site
179408009174	PAS domain S-box; Region: sensory_box; TIGR00229
179408009175	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408009176	putative active site [active]
179408009177	heme pocket [chemical binding]; other site
179408009178	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408009179	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408009180	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408009181	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408009182	dimer interface [polypeptide binding]; other site
179408009183	phosphorylation site [posttranslational modification]
179408009184	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408009185	ATP binding site [chemical binding]; other site
179408009186	Mg2+ binding site [ion binding]; other site
179408009187	G-X-G motif; other site
179408009188	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
179408009189	Cytochrome P450; Region: p450; cl12078
179408009190	MAPEG family; Region: MAPEG; pfam01124
179408009191	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408009192	Coenzyme A binding pocket [chemical binding]; other site
179408009193	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
179408009194	active site
179408009195	dinuclear metal binding site [ion binding]; other site
179408009196	dimerization interface [polypeptide binding]; other site
179408009197	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408009198	TPR repeat; Region: TPR_11; pfam13414
179408009199	binding surface
179408009200	TPR motif; other site
179408009201	TPR repeat; Region: TPR_11; pfam13414
179408009202	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408009203	binding surface
179408009204	TPR motif; other site
179408009205	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
179408009206	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408009207	binding surface
179408009208	TPR motif; other site
179408009209	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
179408009210	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
179408009211	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
179408009212	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
179408009213	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
179408009214	binding surface
179408009215	TPR motif; other site
179408009216	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408009217	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408009218	active site
179408009219	ATP binding site [chemical binding]; other site
179408009220	substrate binding site [chemical binding]; other site
179408009221	activation loop (A-loop); other site
179408009222	PAS fold; Region: PAS_4; pfam08448
179408009223	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408009224	putative active site [active]
179408009225	heme pocket [chemical binding]; other site
179408009226	PAS domain S-box; Region: sensory_box; TIGR00229
179408009227	PAS domain; Region: PAS; smart00091
179408009228	PAS domain S-box; Region: sensory_box; TIGR00229
179408009229	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408009230	putative active site [active]
179408009231	heme pocket [chemical binding]; other site
179408009232	PAS fold; Region: PAS_3; pfam08447
179408009233	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408009234	putative active site [active]
179408009235	heme pocket [chemical binding]; other site
179408009236	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408009237	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408009238	dimer interface [polypeptide binding]; other site
179408009239	phosphorylation site [posttranslational modification]
179408009240	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408009241	ATP binding site [chemical binding]; other site
179408009242	Mg2+ binding site [ion binding]; other site
179408009243	G-X-G motif; other site
179408009244	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364
179408009245	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
179408009246	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408009247	non-specific DNA binding site [nucleotide binding]; other site
179408009248	salt bridge; other site
179408009249	sequence-specific DNA binding site [nucleotide binding]; other site
179408009250	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
179408009251	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
179408009252	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
179408009253	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
179408009254	Predicted integral membrane protein [Function unknown]; Region: COG0762
179408009255	Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596
179408009256	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
179408009257	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408009258	Probable transposase; Region: OrfB_IS605; pfam01385
179408009259	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408009260	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
179408009261	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
179408009262	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
179408009263	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
179408009264	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
179408009265	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
179408009266	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879
179408009267	succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577
179408009268	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
179408009269	hypothetical protein; Reviewed; Region: PRK00024
179408009270	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
179408009271	MPN+ (JAMM) motif; other site
179408009272	Zinc-binding site [ion binding]; other site
179408009273	Domain of unknown function (DUF1815); Region: DUF1815; pfam08844
179408009274	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
179408009275	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
179408009276	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
179408009277	Competence protein; Region: Competence; pfam03772
179408009278	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
179408009279	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
179408009280	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
179408009281	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
179408009282	Ligand binding site; other site
179408009283	Putative Catalytic site; other site
179408009284	DXD motif; other site
179408009285	Predicted membrane protein [Function unknown]; Region: COG2246
179408009286	GtrA-like protein; Region: GtrA; pfam04138
179408009287	FO synthase subunit 2; Reviewed; Region: PRK07360
179408009288	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408009289	FeS/SAM binding site; other site
179408009290	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408009291	putative active site [active]
179408009292	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408009293	non-specific DNA binding site [nucleotide binding]; other site
179408009294	salt bridge; other site
179408009295	sequence-specific DNA binding site [nucleotide binding]; other site
179408009296	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408009297	Walker A/P-loop; other site
179408009298	ATP binding site [chemical binding]; other site
179408009299	AAA domain; Region: AAA_21; pfam13304
179408009300	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
179408009301	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
179408009302	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408009303	homodimer interface [polypeptide binding]; other site
179408009304	catalytic residue [active]
179408009305	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408009306	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408009307	Probable transposase; Region: OrfB_IS605; pfam01385
179408009308	Transposase IS200 like; Region: Y1_Tnp; pfam01797
179408009309	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
179408009310	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
179408009311	haemagglutination activity domain; Region: Haemagg_act; pfam05860
179408009312	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
179408009313	Protein of unknown function DUF262; Region: DUF262; pfam03235
179408009314	Uncharacterized conserved protein [Function unknown]; Region: COG1479
179408009315	Divergent AAA domain; Region: AAA_4; pfam04326
179408009316	Transposase [DNA replication, recombination, and repair]; Region: COG5421
179408009317	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
179408009318	Uncharacterized conserved protein [Function unknown]; Region: COG5464
179408009319	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
179408009320	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
179408009321	cytochrome c biogenesis protein; Region: ccsA; CHL00045
179408009322	KGK domain; Region: KGK; pfam08872
179408009323	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
179408009324	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
179408009325	Ligand Binding Site [chemical binding]; other site
179408009326	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
179408009327	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
179408009328	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
179408009329	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
179408009330	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
179408009331	Response regulator receiver domain; Region: Response_reg; pfam00072
179408009332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408009333	active site
179408009334	phosphorylation site [posttranslational modification]
179408009335	intermolecular recognition site; other site
179408009336	dimerization interface [polypeptide binding]; other site
179408009337	Probable transposase; Region: OrfB_IS605; pfam01385
179408009338	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408009339	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
179408009340	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
179408009341	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408009342	dimerization interface [polypeptide binding]; other site
179408009343	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
179408009344	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
179408009345	dimer interface [polypeptide binding]; other site
179408009346	putative CheW interface [polypeptide binding]; other site
179408009347	HNH endonuclease; Region: HNH_3; pfam13392
179408009348	HNH endonuclease; Region: HNH_3; pfam13392
179408009349	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
179408009350	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
179408009351	putative binding surface; other site
179408009352	active site
179408009353	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
179408009354	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
179408009355	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408009356	ATP binding site [chemical binding]; other site
179408009357	Mg2+ binding site [ion binding]; other site
179408009358	G-X-G motif; other site
179408009359	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
179408009360	Response regulator receiver domain; Region: Response_reg; pfam00072
179408009361	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408009362	active site
179408009363	phosphorylation site [posttranslational modification]
179408009364	intermolecular recognition site; other site
179408009365	dimerization interface [polypeptide binding]; other site
179408009366	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408009367	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408009368	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408009369	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408009370	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408009371	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408009372	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408009373	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
179408009374	homotrimer interaction site [polypeptide binding]; other site
179408009375	putative active site [active]
179408009376	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
179408009377	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
179408009378	RNase E interface [polypeptide binding]; other site
179408009379	trimer interface [polypeptide binding]; other site
179408009380	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
179408009381	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
179408009382	RNase E interface [polypeptide binding]; other site
179408009383	trimer interface [polypeptide binding]; other site
179408009384	active site
179408009385	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
179408009386	putative nucleic acid binding region [nucleotide binding]; other site
179408009387	G-X-X-G motif; other site
179408009388	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
179408009389	RNA binding site [nucleotide binding]; other site
179408009390	domain interface; other site
179408009391	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
179408009392	SNF2 Helicase protein; Region: DUF3670; pfam12419
179408009393	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
179408009394	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
179408009395	thioester formation/cholesterol transfer; other site
179408009396	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
179408009397	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
179408009398	protein-splicing catalytic site; other site
179408009399	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
179408009400	putative Mg++ binding site [ion binding]; other site
179408009401	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
179408009402	nucleotide binding region [chemical binding]; other site
179408009403	ATP-binding site [chemical binding]; other site
179408009404	Uncharacterized conserved protein [Function unknown]; Region: COG4279
179408009405	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268
179408009406	trimer interface [polypeptide binding]; other site
179408009407	putative substrate binding pocket [chemical binding]; other site
179408009408	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
179408009409	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
179408009410	motif II; other site
179408009411	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
179408009412	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
179408009413	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
179408009414	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
179408009415	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
179408009416	SnoaL-like domain; Region: SnoaL_2; pfam12680
179408009417	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
179408009418	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
179408009419	ATP binding site [chemical binding]; other site
179408009420	Mg2+ binding site [ion binding]; other site
179408009421	G-X-G motif; other site
179408009422	Response regulator receiver domain; Region: Response_reg; pfam00072
179408009423	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408009424	active site
179408009425	phosphorylation site [posttranslational modification]
179408009426	intermolecular recognition site; other site
179408009427	dimerization interface [polypeptide binding]; other site
179408009428	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408009429	GAF domain; Region: GAF; pfam01590
179408009430	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
179408009431	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
179408009432	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
179408009433	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
179408009434	DNA binding residues [nucleotide binding]
179408009435	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
179408009436	catalytic residues [active]
179408009437	catalytic nucleophile [active]
179408009438	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
179408009439	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408009440	S-adenosylmethionine binding site [chemical binding]; other site
179408009441	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
179408009442	NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415
179408009443	Uncharacterized conserved protein [Function unknown]; Region: COG1565
179408009444	Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685
179408009445	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408009446	AAA domain; Region: AAA_21; pfam13304
179408009447	Walker A/P-loop; other site
179408009448	ATP binding site [chemical binding]; other site
179408009449	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
179408009450	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
179408009451	cofactor binding site; other site
179408009452	DNA binding site [nucleotide binding]
179408009453	substrate interaction site [chemical binding]; other site
179408009454	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
179408009455	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
179408009456	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
179408009457	dimer interface [polypeptide binding]; other site
179408009458	motif 1; other site
179408009459	active site
179408009460	motif 2; other site
179408009461	motif 3; other site
179408009462	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
179408009463	anticodon binding site; other site
179408009464	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
179408009465	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
179408009466	DNA binding residues [nucleotide binding]
179408009467	dimerization interface [polypeptide binding]; other site
179408009468	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
179408009469	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
179408009470	putative substrate binding site [chemical binding]; other site
179408009471	putative ATP binding site [chemical binding]; other site
179408009472	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
179408009473	ATP-binding site [chemical binding]; other site
179408009474	Gluconate-6-phosphate binding site [chemical binding]; other site
179408009475	Shikimate kinase; Region: SKI; pfam01202
179408009476	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
179408009477	amphipathic channel; other site
179408009478	Asn-Pro-Ala signature motifs; other site
179408009479	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
179408009480	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
179408009481	substrate binding site [chemical binding]; other site
179408009482	ligand binding site [chemical binding]; other site
179408009483	WD domain, G-beta repeat; Region: WD40; pfam00400
179408009484	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408009485	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408009486	structural tetrad; other site
179408009487	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408009488	structural tetrad; other site
179408009489	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408009490	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408009491	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
179408009492	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
179408009493	DDE superfamily endonuclease; Region: DDE_3; pfam13358
179408009494	WD domain, G-beta repeat; Region: WD40; pfam00400
179408009495	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408009496	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408009497	structural tetrad; other site
179408009498	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408009499	structural tetrad; other site
179408009500	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408009501	putative active site [active]
179408009502	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408009503	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408009504	dimer interface [polypeptide binding]; other site
179408009505	phosphorylation site [posttranslational modification]
179408009506	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408009507	ATP binding site [chemical binding]; other site
179408009508	Mg2+ binding site [ion binding]; other site
179408009509	G-X-G motif; other site
179408009510	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408009511	GAF domain; Region: GAF; pfam01590
179408009512	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408009513	PAS fold; Region: PAS_3; pfam08447
179408009514	putative active site [active]
179408009515	heme pocket [chemical binding]; other site
179408009516	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408009517	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408009518	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408009519	dimer interface [polypeptide binding]; other site
179408009520	phosphorylation site [posttranslational modification]
179408009521	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
179408009522	Mg2+ binding site [ion binding]; other site
179408009523	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408009524	ATP binding site [chemical binding]; other site
179408009525	G-X-G motif; other site
179408009526	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408009527	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408009528	active site
179408009529	phosphorylation site [posttranslational modification]
179408009530	intermolecular recognition site; other site
179408009531	dimerization interface [polypeptide binding]; other site
179408009532	Response regulator receiver domain; Region: Response_reg; pfam00072
179408009533	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408009534	active site
179408009535	phosphorylation site [posttranslational modification]
179408009536	intermolecular recognition site; other site
179408009537	dimerization interface [polypeptide binding]; other site
179408009538	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
179408009539	cyclase homology domain; Region: CHD; cd07302
179408009540	nucleotidyl binding site; other site
179408009541	metal binding site [ion binding]; metal-binding site
179408009542	dimer interface [polypeptide binding]; other site
179408009543	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
179408009544	Resolvase, N terminal domain; Region: Resolvase; smart00857
179408009545	Recombinase; Region: Recombinase; pfam07508
179408009546	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
179408009547	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
179408009548	dimer interface [polypeptide binding]; other site
179408009549	putative metal binding site [ion binding]; other site
179408009550	Cache domain; Region: Cache_1; pfam02743
179408009551	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
179408009552	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408009553	dimerization interface [polypeptide binding]; other site
179408009554	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
179408009555	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
179408009556	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
179408009557	cyclase homology domain; Region: CHD; cd07302
179408009558	nucleotidyl binding site; other site
179408009559	metal binding site [ion binding]; metal-binding site
179408009560	dimer interface [polypeptide binding]; other site
179408009561	Tetratricopeptide repeat; Region: TPR_16; pfam13432
179408009562	Tetratricopeptide repeat; Region: TPR_2; pfam07719
179408009563	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381
179408009564	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
179408009565	anti sigma factor interaction site; other site
179408009566	regulatory phosphorylation site [posttranslational modification]; other site
179408009567	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
179408009568	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408009569	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408009570	ATP binding site [chemical binding]; other site
179408009571	Mg2+ binding site [ion binding]; other site
179408009572	G-X-G motif; other site
179408009573	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
179408009574	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
179408009575	catalytic site [active]
179408009576	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
179408009577	Surface antigen; Region: Bac_surface_Ag; pfam01103
179408009578	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
179408009579	active site
179408009580	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
179408009581	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
179408009582	HEAT-like repeat; Region: HEAT_EZ; pfam13513
179408009583	protein binding surface [polypeptide binding]; other site
179408009584	HEAT repeats; Region: HEAT_2; pfam13646
179408009585	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
179408009586	Acylphosphatase; Region: Acylphosphatase; cl00551
179408009587	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
179408009588	active site
179408009589	photosystem I reaction center subunit PsaK; Region: PS_I_psaK; TIGR03049
179408009590	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
179408009591	Peptidase family M50; Region: Peptidase_M50; pfam02163
179408009592	active site
179408009593	putative substrate binding region [chemical binding]; other site
179408009594	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
179408009595	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
179408009596	CHASE2 domain; Region: CHASE2; pfam05226
179408009597	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
179408009598	cyclase homology domain; Region: CHD; cd07302
179408009599	nucleotidyl binding site; other site
179408009600	metal binding site [ion binding]; metal-binding site
179408009601	dimer interface [polypeptide binding]; other site
179408009602	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
179408009603	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
179408009604	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
179408009605	catalytic residues [active]
179408009606	succinyldiaminopimelate transaminase; Validated; Region: PRK07366
179408009607	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
179408009608	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408009609	homodimer interface [polypeptide binding]; other site
179408009610	catalytic residue [active]
179408009611	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
179408009612	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
179408009613	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
179408009614	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
179408009615	dimer interface [polypeptide binding]; other site
179408009616	motif 1; other site
179408009617	active site
179408009618	motif 2; other site
179408009619	motif 3; other site
179408009620	Response regulator receiver domain; Region: Response_reg; pfam00072
179408009621	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408009622	active site
179408009623	phosphorylation site [posttranslational modification]
179408009624	intermolecular recognition site; other site
179408009625	dimerization interface [polypeptide binding]; other site
179408009626	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408009627	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408009628	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408009629	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408009630	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408009631	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408009632	dimer interface [polypeptide binding]; other site
179408009633	phosphorylation site [posttranslational modification]
179408009634	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408009635	ATP binding site [chemical binding]; other site
179408009636	Mg2+ binding site [ion binding]; other site
179408009637	G-X-G motif; other site
179408009638	Response regulator receiver domain; Region: Response_reg; pfam00072
179408009639	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408009640	active site
179408009641	phosphorylation site [posttranslational modification]
179408009642	intermolecular recognition site; other site
179408009643	dimerization interface [polypeptide binding]; other site
179408009644	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
179408009645	cyclase homology domain; Region: CHD; cd07302
179408009646	nucleotidyl binding site; other site
179408009647	metal binding site [ion binding]; metal-binding site
179408009648	dimer interface [polypeptide binding]; other site
179408009649	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
179408009650	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408009651	Coenzyme A binding pocket [chemical binding]; other site
179408009652	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
179408009653	legume lectins; Region: lectin_L-type; cl14058
179408009654	homotetramer interaction site [polypeptide binding]; other site
179408009655	carbohydrate binding site [chemical binding]; other site
179408009656	metal binding site [ion binding]; metal-binding site
179408009657	Domain of unknown function DUF11; Region: DUF11; pfam01345
179408009658	Domain of unknown function DUF11; Region: DUF11; pfam01345
179408009659	Domain of unknown function DUF11; Region: DUF11; pfam01345
179408009660	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408009661	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
179408009662	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
179408009663	recombination protein RecR; Reviewed; Region: recR; PRK00076
179408009664	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
179408009665	RecR protein; Region: RecR; pfam02132
179408009666	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
179408009667	putative active site [active]
179408009668	putative metal-binding site [ion binding]; other site
179408009669	tetramer interface [polypeptide binding]; other site
179408009670	translation initiation factor Sui1; Validated; Region: PRK06824
179408009671	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
179408009672	putative rRNA binding site [nucleotide binding]; other site
179408009673	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
179408009674	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
179408009675	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408009676	catalytic residue [active]
179408009677	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
179408009678	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
179408009679	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
179408009680	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
179408009681	catalytic site [active]
179408009682	putative active site [active]
179408009683	putative substrate binding site [chemical binding]; other site
179408009684	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
179408009685	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
179408009686	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705
179408009687	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
179408009688	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
179408009689	ABC transporter C family member; Provisional; Region: PLN03130
179408009690	MAPEG family; Region: MAPEG; pfam01124
179408009691	Predicted membrane protein [Function unknown]; Region: COG1808
179408009692	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408009693	S-adenosylmethionine binding site [chemical binding]; other site
179408009694	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
179408009695	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
179408009696	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
179408009697	ligand binding site [chemical binding]; other site
179408009698	flexible hinge region; other site
179408009699	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
179408009700	ThiS interaction site; other site
179408009701	putative active site [active]
179408009702	tetramer interface [polypeptide binding]; other site
179408009703	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
179408009704	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408009705	active site
179408009706	phosphorylation site [posttranslational modification]
179408009707	intermolecular recognition site; other site
179408009708	dimerization interface [polypeptide binding]; other site
179408009709	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
179408009710	DNA binding site [nucleotide binding]
179408009711	protoporphyrinogen oxidase; Region: PLN02576
179408009712	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
179408009713	PAS fold; Region: PAS_4; pfam08448
179408009714	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408009715	putative active site [active]
179408009716	heme pocket [chemical binding]; other site
179408009717	PAS domain S-box; Region: sensory_box; TIGR00229
179408009718	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408009719	putative active site [active]
179408009720	heme pocket [chemical binding]; other site
179408009721	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408009722	GAF domain; Region: GAF; pfam01590
179408009723	PAS fold; Region: PAS_4; pfam08448
179408009724	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408009725	putative active site [active]
179408009726	heme pocket [chemical binding]; other site
179408009727	PAS fold; Region: PAS_4; pfam08448
179408009728	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408009729	PAS fold; Region: PAS_3; pfam08447
179408009730	putative active site [active]
179408009731	heme pocket [chemical binding]; other site
179408009732	PAS fold; Region: PAS_4; pfam08448
179408009733	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408009734	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408009735	dimer interface [polypeptide binding]; other site
179408009736	phosphorylation site [posttranslational modification]
179408009737	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408009738	ATP binding site [chemical binding]; other site
179408009739	Mg2+ binding site [ion binding]; other site
179408009740	G-X-G motif; other site
179408009741	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
179408009742	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
179408009743	oligomer interface [polypeptide binding]; other site
179408009744	metal binding site [ion binding]; metal-binding site
179408009745	metal binding site [ion binding]; metal-binding site
179408009746	Cl binding site [ion binding]; other site
179408009747	aspartate ring; other site
179408009748	basic sphincter; other site
179408009749	putative hydrophobic gate; other site
179408009750	periplasmic entrance; other site
179408009751	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
179408009752	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
179408009753	dimerization interface [polypeptide binding]; other site
179408009754	active site
179408009755	metal binding site [ion binding]; metal-binding site
179408009756	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
179408009757	dsRNA binding site [nucleotide binding]; other site
179408009758	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
179408009759	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
179408009760	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408009761	HAMP domain; Region: HAMP; pfam00672
179408009762	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408009763	dimer interface [polypeptide binding]; other site
179408009764	phosphorylation site [posttranslational modification]
179408009765	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408009766	ATP binding site [chemical binding]; other site
179408009767	Mg2+ binding site [ion binding]; other site
179408009768	G-X-G motif; other site
179408009769	Methyltransferase domain; Region: Methyltransf_23; pfam13489
179408009770	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408009771	S-adenosylmethionine binding site [chemical binding]; other site
179408009772	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
179408009773	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
179408009774	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
179408009775	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
179408009776	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
179408009777	ring oligomerisation interface [polypeptide binding]; other site
179408009778	ATP/Mg binding site [chemical binding]; other site
179408009779	stacking interactions; other site
179408009780	hinge regions; other site
179408009781	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
179408009782	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
179408009783	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408009784	Walker A/P-loop; other site
179408009785	ATP binding site [chemical binding]; other site
179408009786	Q-loop/lid; other site
179408009787	ABC transporter signature motif; other site
179408009788	Walker B; other site
179408009789	D-loop; other site
179408009790	H-loop/switch region; other site
179408009791	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
179408009792	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
179408009793	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
179408009794	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
179408009795	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
179408009796	catalytic loop [active]
179408009797	iron binding site [ion binding]; other site
179408009798	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
179408009799	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
179408009800	active site
179408009801	catalytic residues [active]
179408009802	metal binding site [ion binding]; metal-binding site
179408009803	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
179408009804	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
179408009805	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
179408009806	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
179408009807	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
179408009808	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
179408009809	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
179408009810	active site
179408009811	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
179408009812	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
179408009813	TPP-binding site; other site
179408009814	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
179408009815	PYR/PP interface [polypeptide binding]; other site
179408009816	dimer interface [polypeptide binding]; other site
179408009817	TPP binding site [chemical binding]; other site
179408009818	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
179408009819	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408009820	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408009821	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
179408009822	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
179408009823	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
179408009824	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
179408009825	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
179408009826	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
179408009827	putative active site [active]
179408009828	putative metal binding site [ion binding]; other site
179408009829	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
179408009830	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
179408009831	Walker A/P-loop; other site
179408009832	ATP binding site [chemical binding]; other site
179408009833	Q-loop/lid; other site
179408009834	ABC transporter signature motif; other site
179408009835	Walker B; other site
179408009836	D-loop; other site
179408009837	H-loop/switch region; other site
179408009838	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
179408009839	putative carbohydrate binding site [chemical binding]; other site
179408009840	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
179408009841	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
179408009842	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
179408009843	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408009844	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408009845	active site
179408009846	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408009847	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
179408009848	active site
179408009849	N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476
179408009850	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408009851	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408009852	active site
179408009853	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408009854	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408009855	Probable transposase; Region: OrfB_IS605; pfam01385
179408009856	Transposase IS200 like; Region: Y1_Tnp; pfam01797
179408009857	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
179408009858	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
179408009859	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
179408009860	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
179408009861	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
179408009862	putative active site [active]
179408009863	putative metal binding site [ion binding]; other site
179408009864	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
179408009865	active site
179408009866	catalytic residues [active]
179408009867	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
179408009868	intersubunit interface [polypeptide binding]; other site
179408009869	active site
179408009870	zinc binding site [ion binding]; other site
179408009871	Na+ binding site [ion binding]; other site
179408009872	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
179408009873	Protein of unknown function (DUF433); Region: DUF433; pfam04255
179408009874	AAA ATPase domain; Region: AAA_16; pfam13191
179408009875	NACHT domain; Region: NACHT; pfam05729
179408009876	XisI protein; Region: XisI; pfam08869
179408009877	XisH protein; Region: XisH; pfam08814
179408009878	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
179408009879	PGAP1-like protein; Region: PGAP1; pfam07819
179408009880	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
179408009881	nudix motif; other site
179408009882	Methyltransferase domain; Region: Methyltransf_31; pfam13847
179408009883	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408009884	S-adenosylmethionine binding site [chemical binding]; other site
179408009885	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
179408009886	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
179408009887	active site
179408009888	Substrate binding site; other site
179408009889	Mg++ binding site; other site
179408009890	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
179408009891	putative trimer interface [polypeptide binding]; other site
179408009892	putative CoA binding site [chemical binding]; other site
179408009893	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
179408009894	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
179408009895	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
179408009896	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
179408009897	dimer interface [polypeptide binding]; other site
179408009898	ssDNA binding site [nucleotide binding]; other site
179408009899	tetramer (dimer of dimers) interface [polypeptide binding]; other site
179408009900	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408009901	sequence-specific DNA binding site [nucleotide binding]; other site
179408009902	salt bridge; other site
179408009903	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
179408009904	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
179408009905	30S subunit binding site; other site
179408009906	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
179408009907	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
179408009908	catalytic triad [active]
179408009909	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
179408009910	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
179408009911	ABC-ATPase subunit  interface; other site
179408009912	dimer interface [polypeptide binding]; other site
179408009913	putative PBP binding regions; other site
179408009914	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
179408009915	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
179408009916	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
179408009917	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
179408009918	metal binding site [ion binding]; metal-binding site
179408009919	AAA domain; Region: AAA_22; pfam13401
179408009920	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
179408009921	nucleotide binding region [chemical binding]; other site
179408009922	ATP-binding site [chemical binding]; other site
179408009923	YCII-related domain; Region: YCII; cl00999
179408009924	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408009925	putative active site [active]
179408009926	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
179408009927	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
179408009928	putative tRNA-binding site [nucleotide binding]; other site
179408009929	B3/4 domain; Region: B3_4; pfam03483
179408009930	tRNA synthetase B5 domain; Region: B5; smart00874
179408009931	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
179408009932	dimer interface [polypeptide binding]; other site
179408009933	motif 1; other site
179408009934	motif 3; other site
179408009935	motif 2; other site
179408009936	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
179408009937	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408009938	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408009939	active site
179408009940	ATP binding site [chemical binding]; other site
179408009941	substrate binding site [chemical binding]; other site
179408009942	activation loop (A-loop); other site
179408009943	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408009944	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408009945	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408009946	MASE1; Region: MASE1; pfam05231
179408009947	MASE1; Region: MASE1; cl17823
179408009948	PAS fold; Region: PAS_3; pfam08447
179408009949	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408009950	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408009951	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408009952	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408009953	dimer interface [polypeptide binding]; other site
179408009954	phosphorylation site [posttranslational modification]
179408009955	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
179408009956	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408009957	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408009958	ATP binding site [chemical binding]; other site
179408009959	G-X-G motif; other site
179408009960	PAS domain S-box; Region: sensory_box; TIGR00229
179408009961	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408009962	putative active site [active]
179408009963	heme pocket [chemical binding]; other site
179408009964	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408009965	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408009966	dimer interface [polypeptide binding]; other site
179408009967	phosphorylation site [posttranslational modification]
179408009968	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408009969	ATP binding site [chemical binding]; other site
179408009970	Mg2+ binding site [ion binding]; other site
179408009971	G-X-G motif; other site
179408009972	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
179408009973	TPR repeat; Region: TPR_11; pfam13414
179408009974	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408009975	binding surface
179408009976	TPR motif; other site
179408009977	TPR repeat; Region: TPR_11; pfam13414
179408009978	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408009979	binding surface
179408009980	TPR motif; other site
179408009981	TPR repeat; Region: TPR_11; pfam13414
179408009982	TPR repeat; Region: TPR_11; pfam13414
179408009983	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408009984	binding surface
179408009985	TPR motif; other site
179408009986	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432
179408009987	Glucuronate isomerase; Region: UxaC; cl00829
179408009988	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
179408009989	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408009990	GAF domain; Region: GAF; pfam01590
179408009991	Heme NO binding associated; Region: HNOBA; pfam07701
179408009992	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
179408009993	cyclase homology domain; Region: CHD; cd07302
179408009994	nucleotidyl binding site; other site
179408009995	metal binding site [ion binding]; metal-binding site
179408009996	dimer interface [polypeptide binding]; other site
179408009997	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
179408009998	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
179408009999	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
179408010000	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
179408010001	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408010002	homodimer interface [polypeptide binding]; other site
179408010003	catalytic residue [active]
179408010004	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408010005	putative active site [active]
179408010006	Caspase domain; Region: Peptidase_C14; pfam00656
179408010007	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
179408010008	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
179408010009	ATP-sulfurylase; Region: ATPS; cd00517
179408010010	active site
179408010011	HXXH motif; other site
179408010012	flexible loop; other site
179408010013	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
179408010014	Peptidase family M50; Region: Peptidase_M50; pfam02163
179408010015	active site
179408010016	putative substrate binding region [chemical binding]; other site
179408010017	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
179408010018	maltose O-acetyltransferase; Provisional; Region: PRK10092
179408010019	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
179408010020	active site
179408010021	substrate binding site [chemical binding]; other site
179408010022	trimer interface [polypeptide binding]; other site
179408010023	CoA binding site [chemical binding]; other site
179408010024	Cache domain; Region: Cache_1; pfam02743
179408010025	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408010026	GAF domain; Region: GAF; pfam01590
179408010027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408010028	ATP binding site [chemical binding]; other site
179408010029	Mg2+ binding site [ion binding]; other site
179408010030	G-X-G motif; other site
179408010031	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
179408010032	Predicted membrane protein [Function unknown]; Region: COG1971
179408010033	Domain of unknown function DUF; Region: DUF204; pfam02659
179408010034	Domain of unknown function DUF; Region: DUF204; pfam02659
179408010035	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
179408010036	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
179408010037	putative C-terminal domain interface [polypeptide binding]; other site
179408010038	putative GSH binding site (G-site) [chemical binding]; other site
179408010039	putative dimer interface [polypeptide binding]; other site
179408010040	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
179408010041	N-terminal domain interface [polypeptide binding]; other site
179408010042	dimer interface [polypeptide binding]; other site
179408010043	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
179408010044	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
179408010045	cobalamin synthase; Reviewed; Region: cobS; PRK00235
179408010046	Condensation domain; Region: Condensation; pfam00668
179408010047	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
179408010048	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
179408010049	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
179408010050	acyl-activating enzyme (AAE) consensus motif; other site
179408010051	AMP binding site [chemical binding]; other site
179408010052	PilZ domain; Region: PilZ; pfam07238
179408010053	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
179408010054	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
179408010055	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
179408010056	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
179408010057	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
179408010058	active site
179408010059	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
179408010060	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
179408010061	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
179408010062	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
179408010063	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
179408010064	inhibitor-cofactor binding pocket; inhibition site
179408010065	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408010066	catalytic residue [active]
179408010067	Condensation domain; Region: Condensation; pfam00668
179408010068	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
179408010069	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
179408010070	acyl-activating enzyme (AAE) consensus motif; other site
179408010071	AMP binding site [chemical binding]; other site
179408010072	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
179408010073	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
179408010074	Clostridial hydrophobic W; Region: ChW; pfam07538
179408010075	Clostridial hydrophobic W; Region: ChW; pfam07538
179408010076	Clostridial hydrophobic W; Region: ChW; pfam07538
179408010077	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
179408010078	Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728
179408010079	Clostridial hydrophobic W; Region: ChW; pfam07538
179408010080	Clostridial hydrophobic W; Region: ChW; pfam07538
179408010081	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
179408010082	MgtC family; Region: MgtC; pfam02308
179408010083	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
179408010084	nucleotide binding site [chemical binding]; other site
179408010085	Uncharacterized conserved protein [Function unknown]; Region: COG3937
179408010086	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
179408010087	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
179408010088	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
179408010089	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
179408010090	Walker A motif; other site
179408010091	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
179408010092	protein-splicing catalytic site; other site
179408010093	thioester formation/cholesterol transfer; other site
179408010094	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
179408010095	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
179408010096	protein-splicing catalytic site; other site
179408010097	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
179408010098	Walker B motif; other site
179408010099	DNA binding loops [nucleotide binding]
179408010100	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
179408010101	protein-splicing catalytic site; other site
179408010102	thioester formation/cholesterol transfer; other site
179408010103	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
179408010104	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
179408010105	protein-splicing catalytic site; other site
179408010106	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
179408010107	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
179408010108	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
179408010109	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
179408010110	PAS fold; Region: PAS_4; pfam08448
179408010111	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408010112	putative active site [active]
179408010113	heme pocket [chemical binding]; other site
179408010114	PAS fold; Region: PAS_4; pfam08448
179408010115	PAS domain; Region: PAS_9; pfam13426
179408010116	PAS domain S-box; Region: sensory_box; TIGR00229
179408010117	PAS domain; Region: PAS_8; pfam13188
179408010118	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408010119	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408010120	putative active site [active]
179408010121	heme pocket [chemical binding]; other site
179408010122	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408010123	putative active site [active]
179408010124	heme pocket [chemical binding]; other site
179408010125	PAS fold; Region: PAS_4; pfam08448
179408010126	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408010127	putative active site [active]
179408010128	heme pocket [chemical binding]; other site
179408010129	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408010130	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408010131	putative active site [active]
179408010132	heme pocket [chemical binding]; other site
179408010133	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408010134	putative active site [active]
179408010135	heme pocket [chemical binding]; other site
179408010136	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408010137	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408010138	dimer interface [polypeptide binding]; other site
179408010139	phosphorylation site [posttranslational modification]
179408010140	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408010141	ATP binding site [chemical binding]; other site
179408010142	Mg2+ binding site [ion binding]; other site
179408010143	G-X-G motif; other site
179408010144	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408010145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408010146	active site
179408010147	phosphorylation site [posttranslational modification]
179408010148	intermolecular recognition site; other site
179408010149	dimerization interface [polypeptide binding]; other site
179408010150	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408010151	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
179408010152	active site
179408010153	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
179408010154	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
179408010155	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
179408010156	NAD binding site [chemical binding]; other site
179408010157	homodimer interface [polypeptide binding]; other site
179408010158	active site
179408010159	substrate binding site [chemical binding]; other site
179408010160	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914
179408010161	GDP-Fucose binding site [chemical binding]; other site
179408010162	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408010163	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408010164	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
179408010165	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
179408010166	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
179408010167	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
179408010168	Walker A/P-loop; other site
179408010169	ATP binding site [chemical binding]; other site
179408010170	Q-loop/lid; other site
179408010171	ABC transporter signature motif; other site
179408010172	Walker B; other site
179408010173	D-loop; other site
179408010174	H-loop/switch region; other site
179408010175	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408010176	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
179408010177	Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852
179408010178	gliding motility-associated lipoprotein GldK; Region: GldK_short; TIGR03529
179408010179	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
179408010180	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
179408010181	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
179408010182	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
179408010183	NAD(P) binding site [chemical binding]; other site
179408010184	active site
179408010185	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
179408010186	ABC1 family; Region: ABC1; cl17513
179408010187	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
179408010188	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
179408010189	inhibitor-cofactor binding pocket; inhibition site
179408010190	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408010191	catalytic residue [active]
179408010192	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
179408010193	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
179408010194	DDE superfamily endonuclease; Region: DDE_3; pfam13358
179408010195	Protein of unknown function (DUF972); Region: DUF972; pfam06156
179408010196	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
179408010197	Protein of unknown function (DUF760); Region: DUF760; pfam05542
179408010198	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
179408010199	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
179408010200	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
179408010201	protein binding site [polypeptide binding]; other site
179408010202	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
179408010203	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
179408010204	Peptidase family M23; Region: Peptidase_M23; pfam01551
179408010205	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408010206	Protein of unknown function (DUF4058); Region: DUF4058; pfam13267
179408010207	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
179408010208	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
179408010209	putative active site [active]
179408010210	catalytic triad [active]
179408010211	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
179408010212	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
179408010213	metal binding site 2 [ion binding]; metal-binding site
179408010214	putative DNA binding helix; other site
179408010215	metal binding site 1 [ion binding]; metal-binding site
179408010216	dimer interface [polypeptide binding]; other site
179408010217	structural Zn2+ binding site [ion binding]; other site
179408010218	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
179408010219	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
179408010220	putative active site [active]
179408010221	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
179408010222	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408010223	Walker A/P-loop; other site
179408010224	ATP binding site [chemical binding]; other site
179408010225	Q-loop/lid; other site
179408010226	ABC transporter signature motif; other site
179408010227	Walker B; other site
179408010228	D-loop; other site
179408010229	H-loop/switch region; other site
179408010230	Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476
179408010231	putative active site [active]
179408010232	putative catalytic triad [active]
179408010233	cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895
179408010234	cyanobactin biosynthesis protein, PatB/AcyB/McaB family; Region: patB_acyB_mcaB; TIGR04220
179408010235	C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317
179408010236	Ca binding site [ion binding]; other site
179408010237	substrate binding site [chemical binding]; other site
179408010238	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
179408010239	YcaO-like family; Region: YcaO; pfam02624
179408010240	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
179408010241	bacteriocin leader peptide, microcyclamide/patellamide family; Region: het_cyc_patell; TIGR03678
179408010242	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
179408010243	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408010244	S-adenosylmethionine binding site [chemical binding]; other site
179408010245	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
179408010246	putative FMN binding site [chemical binding]; other site
179408010247	NADPH bind site [chemical binding]; other site
179408010248	Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476
179408010249	putative active site [active]
179408010250	putative catalytic triad [active]
179408010251	cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895
179408010252	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
179408010253	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
179408010254	HlyD family secretion protein; Region: HlyD_3; pfam13437
179408010255	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
179408010256	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
179408010257	active site
179408010258	HIGH motif; other site
179408010259	dimer interface [polypeptide binding]; other site
179408010260	KMSKS motif; other site
179408010261	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
179408010262	FAD binding site [chemical binding]; other site
179408010263	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408010264	putative active site [active]
179408010265	conserved hypothetical protein; Region: TIGR02231
179408010266	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
179408010267	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
179408010268	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
179408010269	Response regulator receiver domain; Region: Response_reg; pfam00072
179408010270	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408010271	active site
179408010272	phosphorylation site [posttranslational modification]
179408010273	intermolecular recognition site; other site
179408010274	dimerization interface [polypeptide binding]; other site
179408010275	PAS domain; Region: PAS_9; pfam13426
179408010276	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408010277	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408010278	metal binding site [ion binding]; metal-binding site
179408010279	active site
179408010280	I-site; other site
179408010281	Response regulator receiver domain; Region: Response_reg; pfam00072
179408010282	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408010283	active site
179408010284	phosphorylation site [posttranslational modification]
179408010285	intermolecular recognition site; other site
179408010286	dimerization interface [polypeptide binding]; other site
179408010287	PAS domain; Region: PAS_9; pfam13426
179408010288	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408010289	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408010290	ATP binding site [chemical binding]; other site
179408010291	Mg2+ binding site [ion binding]; other site
179408010292	G-X-G motif; other site
179408010293	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
179408010294	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408010295	dimerization interface [polypeptide binding]; other site
179408010296	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408010297	dimer interface [polypeptide binding]; other site
179408010298	phosphorylation site [posttranslational modification]
179408010299	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408010300	ATP binding site [chemical binding]; other site
179408010301	Mg2+ binding site [ion binding]; other site
179408010302	G-X-G motif; other site
179408010303	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408010304	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408010305	active site
179408010306	phosphorylation site [posttranslational modification]
179408010307	intermolecular recognition site; other site
179408010308	dimerization interface [polypeptide binding]; other site
179408010309	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
179408010310	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
179408010311	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
179408010312	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
179408010313	MAPEG family; Region: MAPEG; cl09190
179408010314	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
179408010315	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
179408010316	DRTGG domain; Region: DRTGG; pfam07085
179408010317	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
179408010318	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
179408010319	DXD motif; other site
179408010320	Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045
179408010321	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
179408010322	CoA-ligase; Region: Ligase_CoA; pfam00549
179408010323	Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074
179408010324	CoA binding domain; Region: CoA_binding; smart00881
179408010325	CoA-ligase; Region: Ligase_CoA; pfam00549
179408010326	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
179408010327	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
179408010328	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
179408010329	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
179408010330	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
179408010331	P-loop; other site
179408010332	Magnesium ion binding site [ion binding]; other site
179408010333	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
179408010334	Magnesium ion binding site [ion binding]; other site
179408010335	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
179408010336	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
179408010337	G1 box; other site
179408010338	putative GEF interaction site [polypeptide binding]; other site
179408010339	GTP/Mg2+ binding site [chemical binding]; other site
179408010340	Switch I region; other site
179408010341	G2 box; other site
179408010342	G3 box; other site
179408010343	Switch II region; other site
179408010344	G4 box; other site
179408010345	G5 box; other site
179408010346	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
179408010347	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
179408010348	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408010349	TPR motif; other site
179408010350	binding surface
179408010351	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408010352	sequence-specific DNA binding site [nucleotide binding]; other site
179408010353	salt bridge; other site
179408010354	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
179408010355	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
179408010356	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
179408010357	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
179408010358	Acyltransferase family; Region: Acyl_transf_3; pfam01757
179408010359	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
179408010360	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
179408010361	Probable Catalytic site; other site
179408010362	Methyltransferase domain; Region: Methyltransf_31; pfam13847
179408010363	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408010364	S-adenosylmethionine binding site [chemical binding]; other site
179408010365	Cupin domain; Region: Cupin_2; cl17218
179408010366	flavodoxin FldA; Validated; Region: PRK09267
179408010367	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
179408010368	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
179408010369	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
179408010370	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
179408010371	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
179408010372	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
179408010373	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408010374	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
179408010375	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408010376	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
179408010377	CAAX protease self-immunity; Region: Abi; pfam02517
179408010378	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
179408010379	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
179408010380	nucleotide binding site [chemical binding]; other site
179408010381	putative NEF/HSP70 interaction site [polypeptide binding]; other site
179408010382	SBD interface [polypeptide binding]; other site
179408010383	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
179408010384	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
179408010385	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
179408010386	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
179408010387	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
179408010388	active site
179408010389	intersubunit interface [polypeptide binding]; other site
179408010390	catalytic residue [active]
179408010391	SnoaL-like domain; Region: SnoaL_2; pfam12680
179408010392	FtsH Extracellular; Region: FtsH_ext; pfam06480
179408010393	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
179408010394	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408010395	Walker A motif; other site
179408010396	ATP binding site [chemical binding]; other site
179408010397	Walker B motif; other site
179408010398	arginine finger; other site
179408010399	Peptidase family M41; Region: Peptidase_M41; pfam01434
179408010400	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
179408010401	Methyltransferase domain; Region: Methyltransf_11; pfam08241
179408010402	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408010403	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
179408010404	Probable Catalytic site; other site
179408010405	metal-binding site
179408010406	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408010407	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
179408010408	Probable Catalytic site; other site
179408010409	metal-binding site
179408010410	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408010411	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
179408010412	active site
179408010413	GNT-I family; Region: GNT-I; pfam03071
179408010414	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
179408010415	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408010416	active site
179408010417	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
179408010418	Domain of unknown function DUF21; Region: DUF21; pfam01595
179408010419	Transporter associated domain; Region: CorC_HlyC; smart01091
179408010420	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
179408010421	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
179408010422	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
179408010423	putative ADP-binding pocket [chemical binding]; other site
179408010424	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
179408010425	catalytic residue [active]
179408010426	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
179408010427	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
179408010428	Walker A/P-loop; other site
179408010429	ATP binding site [chemical binding]; other site
179408010430	Q-loop/lid; other site
179408010431	ABC transporter signature motif; other site
179408010432	Walker B; other site
179408010433	D-loop; other site
179408010434	H-loop/switch region; other site
179408010435	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
179408010436	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408010437	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
179408010438	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
179408010439	Walker A/P-loop; other site
179408010440	ATP binding site [chemical binding]; other site
179408010441	Q-loop/lid; other site
179408010442	ABC transporter signature motif; other site
179408010443	Walker B; other site
179408010444	D-loop; other site
179408010445	H-loop/switch region; other site
179408010446	DevC protein; Region: devC; TIGR01185
179408010447	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
179408010448	FtsX-like permease family; Region: FtsX; pfam02687
179408010449	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
179408010450	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
179408010451	HlyD family secretion protein; Region: HlyD_3; pfam13437
179408010452	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
179408010453	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
179408010454	Mechanosensitive ion channel; Region: MS_channel; pfam00924
179408010455	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
179408010456	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
179408010457	ligand binding site [chemical binding]; other site
179408010458	flexible hinge region; other site
179408010459	PAS fold; Region: PAS_4; pfam08448
179408010460	PAS domain S-box; Region: sensory_box; TIGR00229
179408010461	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408010462	putative active site [active]
179408010463	heme pocket [chemical binding]; other site
179408010464	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408010465	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408010466	putative active site [active]
179408010467	heme pocket [chemical binding]; other site
179408010468	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408010469	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408010470	putative active site [active]
179408010471	heme pocket [chemical binding]; other site
179408010472	PAS fold; Region: PAS_4; pfam08448
179408010473	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408010474	putative active site [active]
179408010475	heme pocket [chemical binding]; other site
179408010476	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408010477	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408010478	putative active site [active]
179408010479	heme pocket [chemical binding]; other site
179408010480	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408010481	putative active site [active]
179408010482	heme pocket [chemical binding]; other site
179408010483	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408010484	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408010485	dimer interface [polypeptide binding]; other site
179408010486	phosphorylation site [posttranslational modification]
179408010487	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408010488	ATP binding site [chemical binding]; other site
179408010489	Mg2+ binding site [ion binding]; other site
179408010490	G-X-G motif; other site
179408010491	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408010492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408010493	active site
179408010494	phosphorylation site [posttranslational modification]
179408010495	intermolecular recognition site; other site
179408010496	dimerization interface [polypeptide binding]; other site
179408010497	Response regulator receiver domain; Region: Response_reg; pfam00072
179408010498	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408010499	active site
179408010500	phosphorylation site [posttranslational modification]
179408010501	intermolecular recognition site; other site
179408010502	dimerization interface [polypeptide binding]; other site
179408010503	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408010504	dimer interface [polypeptide binding]; other site
179408010505	phosphorylation site [posttranslational modification]
179408010506	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408010507	ATP binding site [chemical binding]; other site
179408010508	Mg2+ binding site [ion binding]; other site
179408010509	G-X-G motif; other site
179408010510	putative acyl transferase; Provisional; Region: PRK10502
179408010511	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
179408010512	putative trimer interface [polypeptide binding]; other site
179408010513	putative active site [active]
179408010514	putative substrate binding site [chemical binding]; other site
179408010515	putative CoA binding site [chemical binding]; other site
179408010516	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
179408010517	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
179408010518	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
179408010519	putative metal binding site; other site
179408010520	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408010521	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
179408010522	active site
179408010523	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
179408010524	homotrimer interface [polypeptide binding]; other site
179408010525	Walker A motif; other site
179408010526	GTP binding site [chemical binding]; other site
179408010527	Walker B motif; other site
179408010528	Probable transposase; Region: OrfB_IS605; pfam01385
179408010529	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408010530	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
179408010531	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408010532	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408010533	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
179408010534	putative active site [active]
179408010535	putative NTP binding site [chemical binding]; other site
179408010536	putative nucleic acid binding site [nucleotide binding]; other site
179408010537	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408010538	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408010539	active site
179408010540	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
179408010541	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
179408010542	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
179408010543	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
179408010544	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
179408010545	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
179408010546	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
179408010547	ABC1 family; Region: ABC1; cl17513
179408010548	Transposase domain (DUF772); Region: DUF772; pfam05598
179408010549	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
179408010550	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
179408010551	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
179408010552	DNA binding residues [nucleotide binding]
179408010553	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
179408010554	catalytic residues [active]
179408010555	catalytic nucleophile [active]
179408010556	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408010557	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408010558	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
179408010559	CHAT domain; Region: CHAT; cl17868
179408010560	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408010561	TPR motif; other site
179408010562	binding surface
179408010563	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408010564	binding surface
179408010565	TPR motif; other site
179408010566	TPR repeat; Region: TPR_11; pfam13414
179408010567	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
179408010568	haemagglutination activity domain; Region: Haemagg_act; pfam05860
179408010569	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
179408010570	tellurite resistance protein terB; Region: terB; cd07176
179408010571	putative metal binding site [ion binding]; other site
179408010572	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
179408010573	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
179408010574	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
179408010575	binding surface
179408010576	Tetratricopeptide repeat; Region: TPR_16; pfam13432
179408010577	TPR motif; other site
179408010578	Peptidase family M48; Region: Peptidase_M48; cl12018
179408010579	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
179408010580	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408010581	binding surface
179408010582	TPR motif; other site
179408010583	TPR repeat; Region: TPR_11; pfam13414
179408010584	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408010585	binding surface
179408010586	TPR motif; other site
179408010587	TPR repeat; Region: TPR_11; pfam13414
179408010588	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
179408010589	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
179408010590	G1 box; other site
179408010591	putative GEF interaction site [polypeptide binding]; other site
179408010592	GTP/Mg2+ binding site [chemical binding]; other site
179408010593	Switch I region; other site
179408010594	G2 box; other site
179408010595	G3 box; other site
179408010596	Switch II region; other site
179408010597	G4 box; other site
179408010598	G5 box; other site
179408010599	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
179408010600	Tic20-like protein; Region: Tic20; pfam09685
179408010601	Predicted membrane protein (DUF2127); Region: DUF2127; cl01785
179408010602	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
179408010603	DHH family; Region: DHH; pfam01368
179408010604	FOG: CBS domain [General function prediction only]; Region: COG0517
179408010605	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
179408010606	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
179408010607	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
179408010608	active site
179408010609	NTP binding site [chemical binding]; other site
179408010610	metal binding triad [ion binding]; metal-binding site
179408010611	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
179408010612	photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576
179408010613	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
179408010614	homopentamer interface [polypeptide binding]; other site
179408010615	active site
179408010616	2-epi-5-epi-valiolone synthase (EEVS); Region: EEVS; cd08199
179408010617	active site
179408010618	metal binding site [ion binding]; metal-binding site
179408010619	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
179408010620	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
179408010621	S-adenosylmethionine binding site [chemical binding]; other site
179408010622	hypothetical protein; Provisional; Region: PRK06849
179408010623	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
179408010624	ATP-grasp domain; Region: ATP-grasp_4; cl17255
179408010625	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408010626	putative active site [active]
179408010627	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408010628	putative active site [active]
179408010629	Transposase IS200 like; Region: Y1_Tnp; pfam01797
179408010630	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
179408010631	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
179408010632	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408010633	FeS/SAM binding site; other site
179408010634	DEAD-like helicases superfamily; Region: DEXDc; smart00487
179408010635	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
179408010636	ATP binding site [chemical binding]; other site
179408010637	Mg++ binding site [ion binding]; other site
179408010638	motif III; other site
179408010639	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
179408010640	nucleotide binding region [chemical binding]; other site
179408010641	ATP-binding site [chemical binding]; other site
179408010642	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
179408010643	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
179408010644	putative active site [active]
179408010645	putative NTP binding site [chemical binding]; other site
179408010646	putative nucleic acid binding site [nucleotide binding]; other site
179408010647	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
179408010648	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
179408010649	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
179408010650	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
179408010651	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
179408010652	M28 Zn-Peptidases; Region: M28_like_1; cd05640
179408010653	Peptidase family M28; Region: Peptidase_M28; pfam04389
179408010654	metal binding site [ion binding]; metal-binding site
179408010655	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408010656	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408010657	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408010658	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408010659	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
179408010660	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
179408010661	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408010662	Coenzyme A binding pocket [chemical binding]; other site
179408010663	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
179408010664	trimer interface [polypeptide binding]; other site
179408010665	active site
179408010666	substrate binding site [chemical binding]; other site
179408010667	CoA binding site [chemical binding]; other site
179408010668	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
179408010669	Aluminium resistance protein; Region: Alum_res; pfam06838
179408010670	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
179408010671	Fatty acid desaturase; Region: FA_desaturase; pfam00487
179408010672	Di-iron ligands [ion binding]; other site
179408010673	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
179408010674	Fatty acid desaturase; Region: FA_desaturase; pfam00487
179408010675	Di-iron ligands [ion binding]; other site
179408010676	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
179408010677	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408010678	dimer interface [polypeptide binding]; other site
179408010679	conserved gate region; other site
179408010680	putative PBP binding loops; other site
179408010681	ABC-ATPase subunit interface; other site
179408010682	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
179408010683	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408010684	dimer interface [polypeptide binding]; other site
179408010685	conserved gate region; other site
179408010686	putative PBP binding loops; other site
179408010687	ABC-ATPase subunit interface; other site
179408010688	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
179408010689	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
179408010690	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
179408010691	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
179408010692	Walker A/P-loop; other site
179408010693	ATP binding site [chemical binding]; other site
179408010694	Q-loop/lid; other site
179408010695	ABC transporter signature motif; other site
179408010696	Walker B; other site
179408010697	D-loop; other site
179408010698	H-loop/switch region; other site
179408010699	TOBE domain; Region: TOBE_2; pfam08402
179408010700	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
179408010701	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
179408010702	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
179408010703	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
179408010704	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
179408010705	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
179408010706	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
179408010707	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
179408010708	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
179408010709	Walker A/P-loop; other site
179408010710	ATP binding site [chemical binding]; other site
179408010711	Q-loop/lid; other site
179408010712	ABC transporter signature motif; other site
179408010713	Walker B; other site
179408010714	D-loop; other site
179408010715	H-loop/switch region; other site
179408010716	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408010717	non-specific DNA binding site [nucleotide binding]; other site
179408010718	salt bridge; other site
179408010719	sequence-specific DNA binding site [nucleotide binding]; other site
179408010720	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408010721	putative active site [active]
179408010722	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
179408010723	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408010724	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408010725	structural tetrad; other site
179408010726	Pirin-related protein [General function prediction only]; Region: COG1741
179408010727	Pirin; Region: Pirin; pfam02678
179408010728	Predicted transcriptional regulators [Transcription]; Region: COG1733
179408010729	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
179408010730	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
179408010731	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
179408010732	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
179408010733	tetramer interface [polypeptide binding]; other site
179408010734	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408010735	catalytic residue [active]
179408010736	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
179408010737	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
179408010738	dimer interface [polypeptide binding]; other site
179408010739	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
179408010740	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
179408010741	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
179408010742	nucleotide binding site [chemical binding]; other site
179408010743	putative NEF/HSP70 interaction site [polypeptide binding]; other site
179408010744	SBD interface [polypeptide binding]; other site
179408010745	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408010746	S-adenosylmethionine binding site [chemical binding]; other site
179408010747	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
179408010748	nucleotide binding site/active site [active]
179408010749	HIT family signature motif; other site
179408010750	catalytic residue [active]
179408010751	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
179408010752	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408010753	Coenzyme A binding pocket [chemical binding]; other site
179408010754	Protein of unknown function DUF262; Region: DUF262; pfam03235
179408010755	threonine dehydratase; Reviewed; Region: PRK09224
179408010756	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
179408010757	tetramer interface [polypeptide binding]; other site
179408010758	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408010759	catalytic residue [active]
179408010760	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
179408010761	putative Ile/Val binding site [chemical binding]; other site
179408010762	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
179408010763	putative Ile/Val binding site [chemical binding]; other site
179408010764	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
179408010765	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342
179408010766	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
179408010767	Protein of unknown function (DUF433); Region: DUF433; cl01030
179408010768	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408010769	non-specific DNA binding site [nucleotide binding]; other site
179408010770	salt bridge; other site
179408010771	sequence-specific DNA binding site [nucleotide binding]; other site
179408010772	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408010773	putative active site [active]
179408010774	hypothetical protein; Provisional; Region: PRK06770
179408010775	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
179408010776	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
179408010777	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
179408010778	Homeodomain;  DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; Region: homeodomain; cl00084
179408010779	PemK-like protein; Region: PemK; pfam02452
179408010780	chorismate binding enzyme; Region: Chorismate_bind; cl10555
179408010781	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
179408010782	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408010783	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408010784	structural tetrad; other site
179408010785	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408010786	PAS fold; Region: PAS_4; pfam08448
179408010787	putative active site [active]
179408010788	heme pocket [chemical binding]; other site
179408010789	PAS domain S-box; Region: sensory_box; TIGR00229
179408010790	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408010791	putative active site [active]
179408010792	heme pocket [chemical binding]; other site
179408010793	PAS domain S-box; Region: sensory_box; TIGR00229
179408010794	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408010795	putative active site [active]
179408010796	heme pocket [chemical binding]; other site
179408010797	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
179408010798	Histidine kinase; Region: HisKA_2; pfam07568
179408010799	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408010800	ATP binding site [chemical binding]; other site
179408010801	Mg2+ binding site [ion binding]; other site
179408010802	G-X-G motif; other site
179408010803	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408010804	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408010805	active site
179408010806	phosphorylation site [posttranslational modification]
179408010807	intermolecular recognition site; other site
179408010808	dimerization interface [polypeptide binding]; other site
179408010809	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408010810	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408010811	metal binding site [ion binding]; metal-binding site
179408010812	active site
179408010813	I-site; other site
179408010814	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
179408010815	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
179408010816	HSP70 interaction site [polypeptide binding]; other site
179408010817	CHASE2 domain; Region: CHASE2; cl01732
179408010818	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
179408010819	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
179408010820	ATP binding site [chemical binding]; other site
179408010821	Mg2+ binding site [ion binding]; other site
179408010822	G-X-G motif; other site
179408010823	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
179408010824	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408010825	active site
179408010826	phosphorylation site [posttranslational modification]
179408010827	intermolecular recognition site; other site
179408010828	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
179408010829	DNA binding residues [nucleotide binding]
179408010830	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
179408010831	DNA polymerase I; Region: pola; TIGR00593
179408010832	active site
179408010833	metal binding site 1 [ion binding]; metal-binding site
179408010834	putative 5' ssDNA interaction site; other site
179408010835	metal binding site 3; metal-binding site
179408010836	metal binding site 2 [ion binding]; metal-binding site
179408010837	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
179408010838	putative DNA binding site [nucleotide binding]; other site
179408010839	putative metal binding site [ion binding]; other site
179408010840	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
179408010841	active site
179408010842	catalytic site [active]
179408010843	substrate binding site [chemical binding]; other site
179408010844	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
179408010845	active site
179408010846	DNA binding site [nucleotide binding]
179408010847	catalytic site [active]
179408010848	Staphylococcal nuclease homologues; Region: SNc; smart00318
179408010849	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
179408010850	Catalytic site; other site
179408010851	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408010852	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408010853	Probable transposase; Region: OrfB_IS605; pfam01385
179408010854	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408010855	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
179408010856	dimerization interface [polypeptide binding]; other site
179408010857	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408010858	dimer interface [polypeptide binding]; other site
179408010859	phosphorylation site [posttranslational modification]
179408010860	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408010861	ATP binding site [chemical binding]; other site
179408010862	Mg2+ binding site [ion binding]; other site
179408010863	G-X-G motif; other site
179408010864	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
179408010865	Clp amino terminal domain; Region: Clp_N; pfam02861
179408010866	Clp amino terminal domain; Region: Clp_N; pfam02861
179408010867	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408010868	Walker A motif; other site
179408010869	ATP binding site [chemical binding]; other site
179408010870	Walker B motif; other site
179408010871	arginine finger; other site
179408010872	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408010873	Walker A motif; other site
179408010874	ATP binding site [chemical binding]; other site
179408010875	Walker B motif; other site
179408010876	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
179408010877	Protein of unknown function DUF262; Region: DUF262; pfam03235
179408010878	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
179408010879	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
179408010880	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
179408010881	Mechanosensitive ion channel; Region: MS_channel; pfam00924
179408010882	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
179408010883	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
179408010884	putative substrate translocation pore; other site
179408010885	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
179408010886	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
179408010887	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
179408010888	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
179408010889	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
179408010890	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
179408010891	putative active site [active]
179408010892	putative substrate binding site [chemical binding]; other site
179408010893	putative cosubstrate binding site; other site
179408010894	catalytic site [active]
179408010895	threonine synthase; Reviewed; Region: PRK06721
179408010896	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
179408010897	homodimer interface [polypeptide binding]; other site
179408010898	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408010899	catalytic residue [active]
179408010900	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
179408010901	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
179408010902	putative di-iron ligands [ion binding]; other site
179408010903	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
179408010904	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
179408010905	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
179408010906	P-loop; other site
179408010907	Magnesium ion binding site [ion binding]; other site
179408010908	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
179408010909	Magnesium ion binding site [ion binding]; other site
179408010910	ParB-like nuclease domain; Region: ParBc; pfam02195
179408010911	heat shock protein 70; Region: dnaK; CHL00094
179408010912	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408010913	putative active site [active]
179408010914	XisI protein; Region: XisI; pfam08869
179408010915	XisH protein; Region: XisH; pfam08814
179408010916	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
179408010917	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
179408010918	acyl-activating enzyme (AAE) consensus motif; other site
179408010919	CoA binding site [chemical binding]; other site
179408010920	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408010921	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408010922	active site
179408010923	ATP binding site [chemical binding]; other site
179408010924	substrate binding site [chemical binding]; other site
179408010925	activation loop (A-loop); other site
179408010926	Response regulator receiver domain; Region: Response_reg; pfam00072
179408010927	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408010928	active site
179408010929	phosphorylation site [posttranslational modification]
179408010930	intermolecular recognition site; other site
179408010931	dimerization interface [polypeptide binding]; other site
179408010932	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
179408010933	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
179408010934	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408010935	active site
179408010936	phosphorylation site [posttranslational modification]
179408010937	intermolecular recognition site; other site
179408010938	dimerization interface [polypeptide binding]; other site
179408010939	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
179408010940	dimerization interface [polypeptide binding]; other site
179408010941	DNA binding residues [nucleotide binding]
179408010942	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408010943	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408010944	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408010945	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408010946	Transposase IS200 like; Region: Y1_Tnp; pfam01797
179408010947	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408010948	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408010949	Probable transposase; Region: OrfB_IS605; pfam01385
179408010950	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
179408010951	Phosphoglycerate kinase; Region: PGK; pfam00162
179408010952	substrate binding site [chemical binding]; other site
179408010953	hinge regions; other site
179408010954	ADP binding site [chemical binding]; other site
179408010955	catalytic site [active]
179408010956	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
179408010957	Ligand Binding Site [chemical binding]; other site
179408010958	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
179408010959	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
179408010960	GTP/Mg2+ binding site [chemical binding]; other site
179408010961	G4 box; other site
179408010962	G5 box; other site
179408010963	G1 box; other site
179408010964	Switch I region; other site
179408010965	G2 box; other site
179408010966	G3 box; other site
179408010967	Switch II region; other site
179408010968	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
179408010969	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
179408010970	MOSC domain; Region: MOSC; pfam03473
179408010971	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
179408010972	active site clefts [active]
179408010973	zinc binding site [ion binding]; other site
179408010974	dimer interface [polypeptide binding]; other site
179408010975	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
179408010976	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
179408010977	putative metal binding site; other site
179408010978	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408010979	TPR motif; other site
179408010980	binding surface
179408010981	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408010982	binding surface
179408010983	TPR repeat; Region: TPR_11; pfam13414
179408010984	TPR motif; other site
179408010985	TPR repeat; Region: TPR_11; pfam13414
179408010986	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
179408010987	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
179408010988	tandem repeat interface [polypeptide binding]; other site
179408010989	oligomer interface [polypeptide binding]; other site
179408010990	active site residues [active]
179408010991	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
179408010992	tandem repeat interface [polypeptide binding]; other site
179408010993	oligomer interface [polypeptide binding]; other site
179408010994	active site residues [active]
179408010995	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
179408010996	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
179408010997	homotetramer interface [polypeptide binding]; other site
179408010998	FMN binding site [chemical binding]; other site
179408010999	homodimer contacts [polypeptide binding]; other site
179408011000	putative active site [active]
179408011001	putative substrate binding site [chemical binding]; other site
179408011002	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
179408011003	classical (c) SDRs; Region: SDR_c; cd05233
179408011004	NAD(P) binding site [chemical binding]; other site
179408011005	active site
179408011006	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
179408011007	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
179408011008	substrate binding site [chemical binding]; other site
179408011009	catalytic Zn binding site [ion binding]; other site
179408011010	NAD binding site [chemical binding]; other site
179408011011	structural Zn binding site [ion binding]; other site
179408011012	dimer interface [polypeptide binding]; other site
179408011013	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
179408011014	S-formylglutathione hydrolase; Region: PLN02442
179408011015	TPR repeat; Region: TPR_11; pfam13414
179408011016	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408011017	binding surface
179408011018	TPR motif; other site
179408011019	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
179408011020	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
179408011021	homodimer interface [polypeptide binding]; other site
179408011022	substrate-cofactor binding pocket; other site
179408011023	catalytic residue [active]
179408011024	Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807
179408011025	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
179408011026	Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350
179408011027	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
179408011028	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408011029	S-adenosylmethionine binding site [chemical binding]; other site
179408011030	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408011031	sequence-specific DNA binding site [nucleotide binding]; other site
179408011032	salt bridge; other site
179408011033	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
179408011034	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
179408011035	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
179408011036	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
179408011037	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
179408011038	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
179408011039	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408011040	structural tetrad; other site
179408011041	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408011042	Ion channel; Region: Ion_trans_2; pfam07885
179408011043	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
179408011044	TrkA-N domain; Region: TrkA_N; pfam02254
179408011045	TrkA-C domain; Region: TrkA_C; pfam02080
179408011046	pyruvate kinase; Provisional; Region: PRK06354
179408011047	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
179408011048	domain interfaces; other site
179408011049	active site
179408011050	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
179408011051	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
179408011052	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
179408011053	putative di-iron ligands [ion binding]; other site
179408011054	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
179408011055	homotrimer interaction site [polypeptide binding]; other site
179408011056	active site
179408011057	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
179408011058	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
179408011059	tandem repeat interface [polypeptide binding]; other site
179408011060	oligomer interface [polypeptide binding]; other site
179408011061	active site residues [active]
179408011062	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
179408011063	EamA-like transporter family; Region: EamA; pfam00892
179408011064	EamA-like transporter family; Region: EamA; pfam00892
179408011065	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
179408011066	putative active site [active]
179408011067	AAA ATPase domain; Region: AAA_15; pfam13175
179408011068	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408011069	Walker A/P-loop; other site
179408011070	ATP binding site [chemical binding]; other site
179408011071	M28 Zn-Peptidases; Region: M28_like_1; cd05640
179408011072	Peptidase family M28; Region: Peptidase_M28; pfam04389
179408011073	metal binding site [ion binding]; metal-binding site
179408011074	5-oxoprolinase; Region: PLN02666
179408011075	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
179408011076	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
179408011077	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
179408011078	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
179408011079	Transposase [DNA replication, recombination, and repair]; Region: COG5421
179408011080	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
179408011081	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
179408011082	catalytic loop [active]
179408011083	iron binding site [ion binding]; other site
179408011084	trehalose synthase; Region: treS_nterm; TIGR02456
179408011085	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
179408011086	active site
179408011087	catalytic site [active]
179408011088	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
179408011089	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
179408011090	Clp protease ATP binding subunit; Region: clpC; CHL00095
179408011091	Clp amino terminal domain; Region: Clp_N; pfam02861
179408011092	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408011093	Walker A motif; other site
179408011094	ATP binding site [chemical binding]; other site
179408011095	Walker B motif; other site
179408011096	arginine finger; other site
179408011097	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408011098	Walker A motif; other site
179408011099	ATP binding site [chemical binding]; other site
179408011100	Walker B motif; other site
179408011101	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
179408011102	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
179408011103	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
179408011104	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
179408011105	active site
179408011106	catalytic triad [active]
179408011107	oxyanion hole [active]
179408011108	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
179408011109	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
179408011110	dimer interface [polypeptide binding]; other site
179408011111	active site
179408011112	metal binding site [ion binding]; metal-binding site
179408011113	glutathione binding site [chemical binding]; other site
179408011114	Plastocyanin domain containing protein [General function prediction only]; Region: COG4633
179408011115	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
179408011116	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
179408011117	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
179408011118	metal-binding site [ion binding]
179408011119	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
179408011120	Soluble P-type ATPase [General function prediction only]; Region: COG4087
179408011121	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
179408011122	metal-binding site [ion binding]
179408011123	Domain of unknown function (DUF305); Region: DUF305; pfam03713
179408011124	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
179408011125	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
179408011126	HlyD family secretion protein; Region: HlyD_3; pfam13437
179408011127	TIGR04255 family protein; Region: sporadTIGR04255
179408011128	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
179408011129	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
179408011130	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
179408011131	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408011132	active site
179408011133	phosphorylation site [posttranslational modification]
179408011134	intermolecular recognition site; other site
179408011135	dimerization interface [polypeptide binding]; other site
179408011136	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
179408011137	DNA binding site [nucleotide binding]
179408011138	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408011139	ATP binding site [chemical binding]; other site
179408011140	Mg2+ binding site [ion binding]; other site
179408011141	G-X-G motif; other site
179408011142	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
179408011143	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
179408011144	active site
179408011145	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
179408011146	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
179408011147	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
179408011148	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
179408011149	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408011150	dimerization interface [polypeptide binding]; other site
179408011151	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
179408011152	dimer interface [polypeptide binding]; other site
179408011153	phosphorylation site [posttranslational modification]
179408011154	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408011155	ATP binding site [chemical binding]; other site
179408011156	Mg2+ binding site [ion binding]; other site
179408011157	G-X-G motif; other site
179408011158	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
179408011159	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
179408011160	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
179408011161	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
179408011162	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
179408011163	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
179408011164	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
179408011165	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408011166	active site
179408011167	phosphorylation site [posttranslational modification]
179408011168	intermolecular recognition site; other site
179408011169	dimerization interface [polypeptide binding]; other site
179408011170	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
179408011171	DNA binding site [nucleotide binding]
179408011172	PemK-like protein; Region: PemK; pfam02452
179408011173	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
179408011174	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408011175	dimer interface [polypeptide binding]; other site
179408011176	phosphorylation site [posttranslational modification]
179408011177	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408011178	ATP binding site [chemical binding]; other site
179408011179	Mg2+ binding site [ion binding]; other site
179408011180	G-X-G motif; other site
179408011181	heat shock protein 90; Provisional; Region: PRK05218
179408011182	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408011183	ATP binding site [chemical binding]; other site
179408011184	Mg2+ binding site [ion binding]; other site
179408011185	G-X-G motif; other site
179408011186	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
179408011187	MASE1; Region: MASE1; pfam05231
179408011188	PAS domain S-box; Region: sensory_box; TIGR00229
179408011189	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408011190	putative active site [active]
179408011191	heme pocket [chemical binding]; other site
179408011192	Heme NO binding associated; Region: HNOBA; pfam07701
179408011193	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
179408011194	cyclase homology domain; Region: CHD; cd07302
179408011195	nucleotidyl binding site; other site
179408011196	metal binding site [ion binding]; metal-binding site
179408011197	dimer interface [polypeptide binding]; other site
179408011198	MASE1; Region: MASE1; pfam05231
179408011199	PAS domain S-box; Region: sensory_box; TIGR00229
179408011200	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408011201	putative active site [active]
179408011202	heme pocket [chemical binding]; other site
179408011203	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408011204	GAF domain; Region: GAF; pfam01590
179408011205	PAS domain S-box; Region: sensory_box; TIGR00229
179408011206	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408011207	putative active site [active]
179408011208	heme pocket [chemical binding]; other site
179408011209	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
179408011210	cyclase homology domain; Region: CHD; cd07302
179408011211	nucleotidyl binding site; other site
179408011212	metal binding site [ion binding]; metal-binding site
179408011213	dimer interface [polypeptide binding]; other site
179408011214	prolyl-tRNA synthetase; Provisional; Region: PRK09194
179408011215	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
179408011216	dimer interface [polypeptide binding]; other site
179408011217	motif 1; other site
179408011218	active site
179408011219	motif 2; other site
179408011220	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
179408011221	putative deacylase active site [active]
179408011222	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
179408011223	active site
179408011224	motif 3; other site
179408011225	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
179408011226	anticodon binding site; other site
179408011227	Major Facilitator Superfamily; Region: MFS_1; pfam07690
179408011228	Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442
179408011229	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
179408011230	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408011231	putative active site [active]
179408011232	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
179408011233	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
179408011234	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
179408011235	active site
179408011236	metal binding site [ion binding]; metal-binding site
179408011237	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
179408011238	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408011239	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408011240	binding surface
179408011241	TPR motif; other site
179408011242	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
179408011243	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
179408011244	Transposase [DNA replication, recombination, and repair]; Region: COG5421
179408011245	S-layer homology domain; Region: SLH; pfam00395
179408011246	S-layer homology domain; Region: SLH; pfam00395
179408011247	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
179408011248	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
179408011249	NodB motif; other site
179408011250	active site
179408011251	catalytic site [active]
179408011252	metal binding site [ion binding]; metal-binding site
179408011253	Uncharacterized conserved protein [Function unknown]; Region: COG2442
179408011254	putative mercuric reductase; Provisional; Region: PRK13748
179408011255	ChaB; Region: ChaB; pfam06150
179408011256	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
179408011257	Rubredoxin; Region: Rubredoxin; pfam00301
179408011258	iron binding site [ion binding]; other site
179408011259	flavoprotein, HI0933 family; Region: TIGR00275
179408011260	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
179408011261	ATP binding site [chemical binding]; other site
179408011262	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
179408011263	hypothetical protein; Provisional; Region: PRK06208
179408011264	intersubunit interface [polypeptide binding]; other site
179408011265	active site
179408011266	Zn2+ binding site [ion binding]; other site
179408011267	HEAT repeats; Region: HEAT_2; pfam13646
179408011268	HEAT repeats; Region: HEAT_2; pfam13646
179408011269	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
179408011270	protein binding surface [polypeptide binding]; other site
179408011271	HEAT repeats; Region: HEAT_2; pfam13646
179408011272	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
179408011273	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408011274	Coenzyme A binding pocket [chemical binding]; other site
179408011275	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
179408011276	nucleophilic elbow; other site
179408011277	catalytic triad; other site
179408011278	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408011279	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
179408011280	nucleophilic elbow; other site
179408011281	catalytic triad; other site
179408011282	muropeptide transporter; Reviewed; Region: ampG; PRK11902
179408011283	muropeptide transporter; Validated; Region: ampG; cl17669
179408011284	Methyltransferase domain; Region: Methyltransf_26; pfam13659
179408011285	BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616
179408011286	Predicted transcriptional regulator [Transcription]; Region: COG3905
179408011287	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
179408011288	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
179408011289	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
179408011290	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408011291	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
179408011292	Histidine kinase; Region: HisKA_3; pfam07730
179408011293	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408011294	ATP binding site [chemical binding]; other site
179408011295	Mg2+ binding site [ion binding]; other site
179408011296	G-X-G motif; other site
179408011297	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
179408011298	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408011299	active site
179408011300	phosphorylation site [posttranslational modification]
179408011301	intermolecular recognition site; other site
179408011302	dimerization interface [polypeptide binding]; other site
179408011303	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
179408011304	DNA binding residues [nucleotide binding]
179408011305	dimerization interface [polypeptide binding]; other site
179408011306	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622
179408011307	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408011308	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408011309	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408011310	CHAT domain; Region: CHAT; pfam12770
179408011311	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
179408011312	recombination regulator RecX; Reviewed; Region: recX; PRK00117
179408011313	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
179408011314	Predicted membrane protein [Function unknown]; Region: COG4270
179408011315	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
179408011316	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
179408011317	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
179408011318	dimer interface [polypeptide binding]; other site
179408011319	catalytic residues [active]
179408011320	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
179408011321	UreF; Region: UreF; pfam01730
179408011322	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
179408011323	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
179408011324	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
179408011325	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
179408011326	active site
179408011327	homodimer interface [polypeptide binding]; other site
179408011328	SnoaL-like domain; Region: SnoaL_2; pfam12680
179408011329	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
179408011330	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
179408011331	putative NAD(P) binding site [chemical binding]; other site
179408011332	homodimer interface [polypeptide binding]; other site
179408011333	homotetramer interface [polypeptide binding]; other site
179408011334	active site
179408011335	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
179408011336	active site
179408011337	catalytic triad [active]
179408011338	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408011339	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011340	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011341	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011342	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011343	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408011344	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011345	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011346	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
179408011347	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
179408011348	catalytic triad [active]
179408011349	putative active site [active]
179408011350	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
179408011351	active site
179408011352	nucleophile elbow; other site
179408011353	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
179408011354	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408011355	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408011356	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408011357	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408011358	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
179408011359	putative active site [active]
179408011360	putative NTP binding site [chemical binding]; other site
179408011361	putative nucleic acid binding site [nucleotide binding]; other site
179408011362	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408011363	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408011364	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408011365	active site
179408011366	Protein kinase domain; Region: Pkinase; pfam00069
179408011367	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408011368	active site
179408011369	ATP binding site [chemical binding]; other site
179408011370	substrate binding site [chemical binding]; other site
179408011371	activation loop (A-loop); other site
179408011372	AAA ATPase domain; Region: AAA_16; pfam13191
179408011373	Predicted ATPase [General function prediction only]; Region: COG3899
179408011374	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408011375	GAF domain; Region: GAF; pfam01590
179408011376	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408011377	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408011378	dimer interface [polypeptide binding]; other site
179408011379	phosphorylation site [posttranslational modification]
179408011380	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408011381	ATP binding site [chemical binding]; other site
179408011382	Mg2+ binding site [ion binding]; other site
179408011383	G-X-G motif; other site
179408011384	AMIN domain; Region: AMIN; pfam11741
179408011385	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
179408011386	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
179408011387	Response regulator receiver domain; Region: Response_reg; pfam00072
179408011388	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408011389	active site
179408011390	phosphorylation site [posttranslational modification]
179408011391	intermolecular recognition site; other site
179408011392	dimerization interface [polypeptide binding]; other site
179408011393	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408011394	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408011395	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
179408011396	cyclase homology domain; Region: CHD; cd07302
179408011397	nucleotidyl binding site; other site
179408011398	metal binding site [ion binding]; metal-binding site
179408011399	dimer interface [polypeptide binding]; other site
179408011400	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408011401	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408011402	active site
179408011403	phosphorylation site [posttranslational modification]
179408011404	intermolecular recognition site; other site
179408011405	dimerization interface [polypeptide binding]; other site
179408011406	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
179408011407	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408011408	putative active site [active]
179408011409	heme pocket [chemical binding]; other site
179408011410	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408011411	dimer interface [polypeptide binding]; other site
179408011412	phosphorylation site [posttranslational modification]
179408011413	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408011414	ATP binding site [chemical binding]; other site
179408011415	Mg2+ binding site [ion binding]; other site
179408011416	G-X-G motif; other site
179408011417	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408011418	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408011419	active site
179408011420	phosphorylation site [posttranslational modification]
179408011421	intermolecular recognition site; other site
179408011422	dimerization interface [polypeptide binding]; other site
179408011423	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408011424	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408011425	active site
179408011426	phosphorylation site [posttranslational modification]
179408011427	intermolecular recognition site; other site
179408011428	dimerization interface [polypeptide binding]; other site
179408011429	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408011430	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408011431	active site
179408011432	phosphorylation site [posttranslational modification]
179408011433	intermolecular recognition site; other site
179408011434	dimerization interface [polypeptide binding]; other site
179408011435	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
179408011436	phosphorylation site [posttranslational modification]
179408011437	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408011438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408011439	ATP binding site [chemical binding]; other site
179408011440	Mg2+ binding site [ion binding]; other site
179408011441	G-X-G motif; other site
179408011442	Cache domain; Region: Cache_1; pfam02743
179408011443	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408011444	dimerization interface [polypeptide binding]; other site
179408011445	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408011446	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408011447	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408011448	putative active site [active]
179408011449	heme pocket [chemical binding]; other site
179408011450	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408011451	putative active site [active]
179408011452	heme pocket [chemical binding]; other site
179408011453	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408011454	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408011455	dimer interface [polypeptide binding]; other site
179408011456	phosphorylation site [posttranslational modification]
179408011457	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408011458	ATP binding site [chemical binding]; other site
179408011459	Mg2+ binding site [ion binding]; other site
179408011460	G-X-G motif; other site
179408011461	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408011462	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408011463	active site
179408011464	phosphorylation site [posttranslational modification]
179408011465	intermolecular recognition site; other site
179408011466	dimerization interface [polypeptide binding]; other site
179408011467	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
179408011468	conserved cys residue [active]
179408011469	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
179408011470	DEAD-like helicases superfamily; Region: DEXDc; smart00487
179408011471	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
179408011472	ATP binding site [chemical binding]; other site
179408011473	putative Mg++ binding site [ion binding]; other site
179408011474	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
179408011475	nucleotide binding region [chemical binding]; other site
179408011476	ATP-binding site [chemical binding]; other site
179408011477	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
179408011478	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
179408011479	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
179408011480	active site
179408011481	Zn binding site [ion binding]; other site
179408011482	PRC-barrel domain; Region: PRC; pfam05239
179408011483	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
179408011484	Domain of unknown function (DUF2382); Region: DUF2382; cl01590
179408011485	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
179408011486	catalytic residues [active]
179408011487	dimer interface [polypeptide binding]; other site
179408011488	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
179408011489	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
179408011490	active site
179408011491	metal binding site [ion binding]; metal-binding site
179408011492	CHASE3 domain; Region: CHASE3; pfam05227
179408011493	PAS domain S-box; Region: sensory_box; TIGR00229
179408011494	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408011495	putative active site [active]
179408011496	heme pocket [chemical binding]; other site
179408011497	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408011498	PAS domain; Region: PAS_9; pfam13426
179408011499	putative active site [active]
179408011500	heme pocket [chemical binding]; other site
179408011501	PAS domain S-box; Region: sensory_box; TIGR00229
179408011502	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408011503	putative active site [active]
179408011504	heme pocket [chemical binding]; other site
179408011505	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408011506	dimer interface [polypeptide binding]; other site
179408011507	phosphorylation site [posttranslational modification]
179408011508	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408011509	ATP binding site [chemical binding]; other site
179408011510	Mg2+ binding site [ion binding]; other site
179408011511	G-X-G motif; other site
179408011512	PAS domain S-box; Region: sensory_box; TIGR00229
179408011513	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408011514	putative active site [active]
179408011515	heme pocket [chemical binding]; other site
179408011516	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408011517	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408011518	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408011519	dimer interface [polypeptide binding]; other site
179408011520	phosphorylation site [posttranslational modification]
179408011521	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408011522	ATP binding site [chemical binding]; other site
179408011523	Mg2+ binding site [ion binding]; other site
179408011524	G-X-G motif; other site
179408011525	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
179408011526	anti sigma factor interaction site; other site
179408011527	regulatory phosphorylation site [posttranslational modification]; other site
179408011528	cyanate hydratase; Validated; Region: PRK02866
179408011529	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
179408011530	oligomer interface [polypeptide binding]; other site
179408011531	active site
179408011532	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
179408011533	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
179408011534	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
179408011535	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408011536	Walker A motif; other site
179408011537	ATP binding site [chemical binding]; other site
179408011538	Walker B motif; other site
179408011539	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
179408011540	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
179408011541	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408011542	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408011543	active site
179408011544	ATP binding site [chemical binding]; other site
179408011545	substrate binding site [chemical binding]; other site
179408011546	activation loop (A-loop); other site
179408011547	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408011548	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408011549	active site
179408011550	ATP binding site [chemical binding]; other site
179408011551	substrate binding site [chemical binding]; other site
179408011552	activation loop (A-loop); other site
179408011553	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
179408011554	Predicted metal-binding protein [Function unknown]; Region: COG5469
179408011555	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
179408011556	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
179408011557	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
179408011558	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
179408011559	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
179408011560	P-loop, Walker A motif; other site
179408011561	Base recognition motif; other site
179408011562	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
179408011563	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408011564	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408011565	structural tetrad; other site
179408011566	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
179408011567	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
179408011568	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
179408011569	ABC-ATPase subunit  interface; other site
179408011570	dimer interface [polypeptide binding]; other site
179408011571	putative PBP binding regions; other site
179408011572	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
179408011573	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
179408011574	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
179408011575	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
179408011576	intersubunit interface [polypeptide binding]; other site
179408011577	Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069
179408011578	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
179408011579	dimerization interface [polypeptide binding]; other site
179408011580	putative DNA binding site [nucleotide binding]; other site
179408011581	putative Zn2+ binding site [ion binding]; other site
179408011582	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
179408011583	metal-binding site [ion binding]
179408011584	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
179408011585	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
179408011586	DNA binding residues [nucleotide binding]
179408011587	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
179408011588	catalytic residues [active]
179408011589	catalytic nucleophile [active]
179408011590	ParG; Region: ParG; pfam09274
179408011591	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
179408011592	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
179408011593	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
179408011594	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
179408011595	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408011596	putative active site [active]
179408011597	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
179408011598	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
179408011599	TPR repeat; Region: TPR_11; pfam13414
179408011600	TPR repeat; Region: TPR_11; pfam13414
179408011601	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408011602	binding surface
179408011603	TPR motif; other site
179408011604	TPR repeat; Region: TPR_11; pfam13414
179408011605	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408011606	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408011607	binding surface
179408011608	TPR motif; other site
179408011609	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
179408011610	haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1
179408011611	hypothetical protein; Provisional; Region: PRK02724
179408011612	Methyltransferase domain; Region: Methyltransf_31; pfam13847
179408011613	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408011614	S-adenosylmethionine binding site [chemical binding]; other site
179408011615	tellurium resistance terB-like protein; Region: terB_like; cd07177
179408011616	metal binding site [ion binding]; metal-binding site
179408011617	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
179408011618	GTPase CgtA; Reviewed; Region: obgE; PRK12299
179408011619	GTP1/OBG; Region: GTP1_OBG; pfam01018
179408011620	Obg GTPase; Region: Obg; cd01898
179408011621	G1 box; other site
179408011622	GTP/Mg2+ binding site [chemical binding]; other site
179408011623	Switch I region; other site
179408011624	G2 box; other site
179408011625	G3 box; other site
179408011626	Switch II region; other site
179408011627	G4 box; other site
179408011628	G5 box; other site
179408011629	single-stranded DNA-binding protein; Region: PHA00458
179408011630	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
179408011631	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
179408011632	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
179408011633	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
179408011634	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
179408011635	Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514
179408011636	active site
179408011637	dimer interface [polypeptide binding]; other site
179408011638	catalytic nucleophile [active]
179408011639	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360
179408011640	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
179408011641	Substrate binding site; other site
179408011642	Mg++ binding site; other site
179408011643	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
179408011644	active site
179408011645	substrate binding site [chemical binding]; other site
179408011646	CoA binding site [chemical binding]; other site
179408011647	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
179408011648	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
179408011649	active site residue [active]
179408011650	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
179408011651	active site residue [active]
179408011652	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
179408011653	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
179408011654	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408011655	ATP binding site [chemical binding]; other site
179408011656	Mg2+ binding site [ion binding]; other site
179408011657	G-X-G motif; other site
179408011658	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408011659	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408011660	dimer interface [polypeptide binding]; other site
179408011661	phosphorylation site [posttranslational modification]
179408011662	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408011663	ATP binding site [chemical binding]; other site
179408011664	Mg2+ binding site [ion binding]; other site
179408011665	G-X-G motif; other site
179408011666	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
179408011667	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
179408011668	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
179408011669	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
179408011670	ATP binding site [chemical binding]; other site
179408011671	Mg2+ binding site [ion binding]; other site
179408011672	G-X-G motif; other site
179408011673	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
179408011674	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
179408011675	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
179408011676	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
179408011677	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
179408011678	active site
179408011679	nucleotide binding site [chemical binding]; other site
179408011680	HIGH motif; other site
179408011681	KMSKS motif; other site
179408011682	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
179408011683	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
179408011684	putative metal binding site; other site
179408011685	glycogen branching enzyme; Provisional; Region: PRK05402
179408011686	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
179408011687	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
179408011688	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
179408011689	active site
179408011690	catalytic site [active]
179408011691	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
179408011692	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
179408011693	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
179408011694	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
179408011695	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408011696	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408011697	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408011698	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
179408011699	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
179408011700	putative active site [active]
179408011701	putative metal binding site [ion binding]; other site
179408011702	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408011703	putative active site [active]
179408011704	Bacterial SH3 domain; Region: SH3_3; pfam08239
179408011705	Bacterial SH3 domain homologues; Region: SH3b; smart00287
179408011706	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
179408011707	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
179408011708	active site
179408011709	metal binding site [ion binding]; metal-binding site
179408011710	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
179408011711	TrkA-N domain; Region: TrkA_N; pfam02254
179408011712	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
179408011713	TrkA-N domain; Region: TrkA_N; pfam02254
179408011714	Circadian oscillating protein COP23; Region: COP23; pfam14218
179408011715	magnesium chelatase subunit H; Provisional; Region: PLN03241
179408011716	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
179408011717	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
179408011718	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
179408011719	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
179408011720	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
179408011721	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
179408011722	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
179408011723	active site
179408011724	SAM binding site [chemical binding]; other site
179408011725	homodimer interface [polypeptide binding]; other site
179408011726	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408011727	Probable transposase; Region: OrfB_IS605; pfam01385
179408011728	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408011729	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
179408011730	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
179408011731	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
179408011732	TIGR04255 family protein; Region: sporadTIGR04255
179408011733	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
179408011734	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
179408011735	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
179408011736	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011737	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408011738	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011739	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011740	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011741	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011742	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011743	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408011744	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011745	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011746	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011747	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011748	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011749	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011750	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408011751	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011752	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011753	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011754	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011755	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011756	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011757	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408011758	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011759	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408011760	arogenate dehydrogenase; Reviewed; Region: PRK07417
179408011761	prephenate dehydrogenase; Validated; Region: PRK08507
179408011762	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
179408011763	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
179408011764	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
179408011765	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
179408011766	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
179408011767	Walker A/P-loop; other site
179408011768	ATP binding site [chemical binding]; other site
179408011769	Q-loop/lid; other site
179408011770	ABC transporter signature motif; other site
179408011771	Walker B; other site
179408011772	D-loop; other site
179408011773	H-loop/switch region; other site
179408011774	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408011775	S-adenosylmethionine binding site [chemical binding]; other site
179408011776	cyclase homology domain; Region: CHD; cd07302
179408011777	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
179408011778	nucleotidyl binding site; other site
179408011779	metal binding site [ion binding]; metal-binding site
179408011780	dimer interface [polypeptide binding]; other site
179408011781	Response regulator receiver domain; Region: Response_reg; pfam00072
179408011782	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408011783	active site
179408011784	phosphorylation site [posttranslational modification]
179408011785	intermolecular recognition site; other site
179408011786	dimerization interface [polypeptide binding]; other site
179408011787	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
179408011788	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
179408011789	intersubunit interface [polypeptide binding]; other site
179408011790	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
179408011791	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
179408011792	Walker A/P-loop; other site
179408011793	ATP binding site [chemical binding]; other site
179408011794	Q-loop/lid; other site
179408011795	ABC transporter signature motif; other site
179408011796	Walker B; other site
179408011797	D-loop; other site
179408011798	H-loop/switch region; other site
179408011799	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
179408011800	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
179408011801	ABC-ATPase subunit  interface; other site
179408011802	dimer interface [polypeptide binding]; other site
179408011803	putative PBP binding regions; other site
179408011804	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
179408011805	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
179408011806	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
179408011807	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
179408011808	Right handed beta helix region; Region: Beta_helix; pfam13229
179408011809	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
179408011810	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
179408011811	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
179408011812	EamA-like transporter family; Region: EamA; pfam00892
179408011813	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
179408011814	active site
179408011815	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
179408011816	Ligand Binding Site [chemical binding]; other site
179408011817	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
179408011818	Ligand Binding Site [chemical binding]; other site
179408011819	photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989
179408011820	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
179408011821	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
179408011822	catalytic loop [active]
179408011823	iron binding site [ion binding]; other site
179408011824	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
179408011825	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
179408011826	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
179408011827	Protein of unknown function (DUF512); Region: DUF512; pfam04459
179408011828	Ceramidase; Region: Ceramidase; pfam05875
179408011829	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
179408011830	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
179408011831	ligand binding site [chemical binding]; other site
179408011832	flexible hinge region; other site
179408011833	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
179408011834	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408011835	Walker A motif; other site
179408011836	ATP binding site [chemical binding]; other site
179408011837	Walker B motif; other site
179408011838	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
179408011839	4Fe-4S binding domain; Region: Fer4_5; pfam12801
179408011840	Methyltransferase domain; Region: Methyltransf_23; pfam13489
179408011841	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408011842	S-adenosylmethionine binding site [chemical binding]; other site
179408011843	Bacitracin resistance protein BacA; Region: BacA; pfam02673
179408011844	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
179408011845	Trypsin; Region: Trypsin; pfam00089
179408011846	active site
179408011847	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
179408011848	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
179408011849	Substrate binding site; other site
179408011850	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408011851	putative active site [active]
179408011852	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
179408011853	ABC1 family; Region: ABC1; cl17513
179408011854	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
179408011855	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
179408011856	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
179408011857	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
179408011858	FOG: CBS domain [General function prediction only]; Region: COG0517
179408011859	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
179408011860	CP12 domain; Region: CP12; pfam02672
179408011861	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
179408011862	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
179408011863	putative active site [active]
179408011864	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
179408011865	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
179408011866	tRNA; other site
179408011867	putative tRNA binding site [nucleotide binding]; other site
179408011868	putative NADP binding site [chemical binding]; other site
179408011869	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
179408011870	hypothetical protein; Provisional; Region: PRK02509
179408011871	Uncharacterized conserved protein [Function unknown]; Region: COG1615
179408011872	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
179408011873	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
179408011874	active site
179408011875	Peptidase family M50; Region: Peptidase_M50; pfam02163
179408011876	putative substrate binding region [chemical binding]; other site
179408011877	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
179408011878	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
179408011879	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
179408011880	active site
179408011881	substrate binding site [chemical binding]; other site
179408011882	metal binding site [ion binding]; metal-binding site
179408011883	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
179408011884	Calx-beta domain; Region: Calx-beta; pfam03160
179408011885	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
179408011886	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
179408011887	DNA binding residues [nucleotide binding]
179408011888	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
179408011889	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
179408011890	binding surface
179408011891	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408011892	TPR motif; other site
179408011893	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408011894	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
179408011895	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408011896	S-adenosylmethionine binding site [chemical binding]; other site
179408011897	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
179408011898	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
179408011899	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
179408011900	active site
179408011901	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
179408011902	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
179408011903	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
179408011904	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
179408011905	DNA binding residues [nucleotide binding]
179408011906	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
179408011907	catalytic residues [active]
179408011908	catalytic nucleophile [active]
179408011909	sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828
179408011910	active site
179408011911	catalytic triad [active]
179408011912	oxyanion hole [active]
179408011913	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
179408011914	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371
179408011915	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
179408011916	CHASE3 domain; Region: CHASE3; pfam05227
179408011917	PAS domain S-box; Region: sensory_box; TIGR00229
179408011918	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408011919	dimer interface [polypeptide binding]; other site
179408011920	phosphorylation site [posttranslational modification]
179408011921	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408011922	ATP binding site [chemical binding]; other site
179408011923	Mg2+ binding site [ion binding]; other site
179408011924	G-X-G motif; other site
179408011925	Response regulator receiver domain; Region: Response_reg; pfam00072
179408011926	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408011927	active site
179408011928	phosphorylation site [posttranslational modification]
179408011929	intermolecular recognition site; other site
179408011930	dimerization interface [polypeptide binding]; other site
179408011931	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408011932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408011933	active site
179408011934	phosphorylation site [posttranslational modification]
179408011935	intermolecular recognition site; other site
179408011936	dimerization interface [polypeptide binding]; other site
179408011937	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408011938	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408011939	putative active site [active]
179408011940	heme pocket [chemical binding]; other site
179408011941	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408011942	heme pocket [chemical binding]; other site
179408011943	putative active site [active]
179408011944	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408011945	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408011946	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408011947	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408011948	dimer interface [polypeptide binding]; other site
179408011949	phosphorylation site [posttranslational modification]
179408011950	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408011951	ATP binding site [chemical binding]; other site
179408011952	Mg2+ binding site [ion binding]; other site
179408011953	G-X-G motif; other site
179408011954	Response regulator receiver domain; Region: Response_reg; pfam00072
179408011955	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408011956	active site
179408011957	phosphorylation site [posttranslational modification]
179408011958	intermolecular recognition site; other site
179408011959	dimerization interface [polypeptide binding]; other site
179408011960	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408011961	Response regulator receiver domain; Region: Response_reg; pfam00072
179408011962	active site
179408011963	phosphorylation site [posttranslational modification]
179408011964	intermolecular recognition site; other site
179408011965	dimerization interface [polypeptide binding]; other site
179408011966	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
179408011967	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
179408011968	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
179408011969	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
179408011970	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
179408011971	O-Antigen ligase; Region: Wzy_C; pfam04932
179408011972	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
179408011973	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
179408011974	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
179408011975	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
179408011976	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408011977	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
179408011978	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408011979	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408011980	active site
179408011981	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408011982	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
179408011983	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408011984	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
179408011985	CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258
179408011986	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
179408011987	NAD binding site [chemical binding]; other site
179408011988	homotetramer interface [polypeptide binding]; other site
179408011989	homodimer interface [polypeptide binding]; other site
179408011990	active site
179408011991	substrate binding site [chemical binding]; other site
179408011992	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
179408011993	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
179408011994	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
179408011995	active site residue [active]
179408011996	ribosomal protein S4; Reviewed; Region: rps4; CHL00113
179408011997	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
179408011998	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
179408011999	RNA binding surface [nucleotide binding]; other site
179408012000	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
179408012001	heme binding pocket [chemical binding]; other site
179408012002	Animal prostaglandin endoperoxide synthase and related bacterial proteins; Region: prostaglandin_endoperoxide_synthase; cd09816
179408012003	substrate binding site [chemical binding]; other site
179408012004	homodimer interface [polypeptide binding]; other site
179408012005	heme binding site [chemical binding]; other site
179408012006	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
179408012007	Major Facilitator Superfamily; Region: MFS_1; pfam07690
179408012008	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
179408012009	putative substrate translocation pore; other site
179408012010	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
179408012011	GMP synthase; Reviewed; Region: guaA; PRK00074
179408012012	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
179408012013	AMP/PPi binding site [chemical binding]; other site
179408012014	candidate oxyanion hole; other site
179408012015	catalytic triad [active]
179408012016	potential glutamine specificity residues [chemical binding]; other site
179408012017	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
179408012018	ATP Binding subdomain [chemical binding]; other site
179408012019	Ligand Binding sites [chemical binding]; other site
179408012020	Dimerization subdomain; other site
179408012021	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408012022	Probable transposase; Region: OrfB_IS605; pfam01385
179408012023	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408012024	Pirin-related protein [General function prediction only]; Region: COG1741
179408012025	Pirin; Region: Pirin; pfam02678
179408012026	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
179408012027	Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931
179408012028	Neurotransmitter-gated ion-channel transmembrane region; Region: Neur_chan_memb; pfam02932
179408012029	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
179408012030	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408012031	Walker A/P-loop; other site
179408012032	ATP binding site [chemical binding]; other site
179408012033	Q-loop/lid; other site
179408012034	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
179408012035	ABC transporter signature motif; other site
179408012036	Walker B; other site
179408012037	D-loop; other site
179408012038	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
179408012039	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
179408012040	substrate binding pocket [chemical binding]; other site
179408012041	membrane-bound complex binding site; other site
179408012042	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
179408012043	FOG: CBS domain [General function prediction only]; Region: COG0517
179408012044	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
179408012045	FOG: CBS domain [General function prediction only]; Region: COG0517
179408012046	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
179408012047	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012048	PAS fold; Region: PAS_3; pfam08447
179408012049	putative active site [active]
179408012050	heme pocket [chemical binding]; other site
179408012051	PAS fold; Region: PAS; pfam00989
179408012052	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012053	putative active site [active]
179408012054	heme pocket [chemical binding]; other site
179408012055	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408012056	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408012057	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408012058	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408012059	dimer interface [polypeptide binding]; other site
179408012060	phosphorylation site [posttranslational modification]
179408012061	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408012062	ATP binding site [chemical binding]; other site
179408012063	Mg2+ binding site [ion binding]; other site
179408012064	G-X-G motif; other site
179408012065	Response regulator receiver domain; Region: Response_reg; pfam00072
179408012066	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012067	active site
179408012068	phosphorylation site [posttranslational modification]
179408012069	intermolecular recognition site; other site
179408012070	Response regulator receiver domain; Region: Response_reg; pfam00072
179408012071	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012072	active site
179408012073	phosphorylation site [posttranslational modification]
179408012074	intermolecular recognition site; other site
179408012075	dimerization interface [polypeptide binding]; other site
179408012076	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
179408012077	putative binding surface; other site
179408012078	active site
179408012079	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
179408012080	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
179408012081	Walker A/P-loop; other site
179408012082	ATP binding site [chemical binding]; other site
179408012083	Q-loop/lid; other site
179408012084	ABC transporter signature motif; other site
179408012085	Walker B; other site
179408012086	D-loop; other site
179408012087	H-loop/switch region; other site
179408012088	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
179408012089	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
179408012090	Walker A/P-loop; other site
179408012091	ATP binding site [chemical binding]; other site
179408012092	Q-loop/lid; other site
179408012093	ABC transporter signature motif; other site
179408012094	Walker B; other site
179408012095	D-loop; other site
179408012096	H-loop/switch region; other site
179408012097	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
179408012098	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
179408012099	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
179408012100	TM-ABC transporter signature motif; other site
179408012101	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408012102	putative active site [active]
179408012103	TPR repeat; Region: TPR_11; pfam13414
179408012104	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012105	binding surface
179408012106	TPR motif; other site
179408012107	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
179408012108	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012109	TPR motif; other site
179408012110	binding surface
179408012111	Tetratricopeptide repeat; Region: TPR_15; pfam13429
179408012112	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012113	binding surface
179408012114	TPR motif; other site
179408012115	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012116	binding surface
179408012117	TPR motif; other site
179408012118	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012119	binding surface
179408012120	TPR motif; other site
179408012121	TPR repeat; Region: TPR_11; pfam13414
179408012122	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012123	binding surface
179408012124	TPR motif; other site
179408012125	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408012126	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408012127	ATP binding site [chemical binding]; other site
179408012128	Mg2+ binding site [ion binding]; other site
179408012129	G-X-G motif; other site
179408012130	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408012131	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012132	active site
179408012133	phosphorylation site [posttranslational modification]
179408012134	intermolecular recognition site; other site
179408012135	Divergent AAA domain; Region: AAA_4; pfam04326
179408012136	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
179408012137	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
179408012138	TM-ABC transporter signature motif; other site
179408012139	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
179408012140	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
179408012141	dimerization interface [polypeptide binding]; other site
179408012142	ligand binding site [chemical binding]; other site
179408012143	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
179408012144	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408012145	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
179408012146	Coenzyme A binding pocket [chemical binding]; other site
179408012147	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
179408012148	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
179408012149	NAD(P) binding site [chemical binding]; other site
179408012150	active site
179408012151	Translocation protein Sec62; Region: Sec62; cl02170
179408012152	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
179408012153	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
179408012154	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
179408012155	DNA binding residues [nucleotide binding]
179408012156	Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534
179408012157	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
179408012158	dinuclear metal binding motif [ion binding]; other site
179408012159	choline dehydrogenase; Validated; Region: PRK02106
179408012160	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
179408012161	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
179408012162	active site
179408012163	NTP binding site [chemical binding]; other site
179408012164	metal binding triad [ion binding]; metal-binding site
179408012165	antibiotic binding site [chemical binding]; other site
179408012166	hypothetical protein; Provisional; Region: PRK07208
179408012167	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
179408012168	Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111
179408012169	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
179408012170	active site
179408012171	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408012172	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
179408012173	active site
179408012174	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
179408012175	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
179408012176	dimerization interface [polypeptide binding]; other site
179408012177	DPS ferroxidase diiron center [ion binding]; other site
179408012178	ion pore; other site
179408012179	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
179408012180	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
179408012181	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
179408012182	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
179408012183	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
179408012184	Uncharacterized conserved protein [Function unknown]; Region: COG2442
179408012185	Protein of unknown function DUF82; Region: DUF82; pfam01927
179408012186	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
179408012187	DNA methylase; Region: N6_N4_Mtase; cl17433
179408012188	DNA methylase; Region: N6_N4_Mtase; pfam01555
179408012189	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
179408012190	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408012191	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408012192	sucrose synthase; Region: sucr_synth; TIGR02470
179408012193	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
179408012194	putative ADP-binding pocket [chemical binding]; other site
179408012195	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
179408012196	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
179408012197	active site
179408012198	Zn binding site [ion binding]; other site
179408012199	TPR repeat; Region: TPR_11; pfam13414
179408012200	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012201	binding surface
179408012202	TPR motif; other site
179408012203	TPR repeat; Region: TPR_11; pfam13414
179408012204	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012205	binding surface
179408012206	TPR motif; other site
179408012207	TPR repeat; Region: TPR_11; pfam13414
179408012208	TPR repeat; Region: TPR_11; pfam13414
179408012209	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012210	binding surface
179408012211	TPR motif; other site
179408012212	TPR repeat; Region: TPR_11; pfam13414
179408012213	TPR repeat; Region: TPR_11; pfam13414
179408012214	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012215	binding surface
179408012216	TPR motif; other site
179408012217	TPR repeat; Region: TPR_11; pfam13414
179408012218	PemK-like protein; Region: PemK; pfam02452
179408012219	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
179408012220	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012221	binding surface
179408012222	TPR motif; other site
179408012223	TPR repeat; Region: TPR_11; pfam13414
179408012224	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012225	TPR motif; other site
179408012226	TPR repeat; Region: TPR_11; pfam13414
179408012227	binding surface
179408012228	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408012229	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012230	binding surface
179408012231	TPR motif; other site
179408012232	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012233	binding surface
179408012234	TPR repeat; Region: TPR_11; pfam13414
179408012235	TPR motif; other site
179408012236	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012237	binding surface
179408012238	TPR repeat; Region: TPR_11; pfam13414
179408012239	TPR motif; other site
179408012240	TPR repeat; Region: TPR_11; pfam13414
179408012241	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012242	binding surface
179408012243	TPR repeat; Region: TPR_11; pfam13414
179408012244	TPR motif; other site
179408012245	TPR repeat; Region: TPR_11; pfam13414
179408012246	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012247	binding surface
179408012248	TPR motif; other site
179408012249	TPR repeat; Region: TPR_11; pfam13414
179408012250	Protein of function (DUF2518); Region: DUF2518; pfam10726
179408012251	Response regulator receiver domain; Region: Response_reg; pfam00072
179408012252	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012253	active site
179408012254	phosphorylation site [posttranslational modification]
179408012255	intermolecular recognition site; other site
179408012256	dimerization interface [polypeptide binding]; other site
179408012257	Heme NO binding associated; Region: HNOBA; pfam07701
179408012258	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
179408012259	cyclase homology domain; Region: CHD; cd07302
179408012260	nucleotidyl binding site; other site
179408012261	metal binding site [ion binding]; metal-binding site
179408012262	dimer interface [polypeptide binding]; other site
179408012263	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408012264	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012265	active site
179408012266	phosphorylation site [posttranslational modification]
179408012267	intermolecular recognition site; other site
179408012268	dimerization interface [polypeptide binding]; other site
179408012269	PAS fold; Region: PAS; pfam00989
179408012270	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012271	putative active site [active]
179408012272	PAS domain; Region: PAS; smart00091
179408012273	PAS domain S-box; Region: sensory_box; TIGR00229
179408012274	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408012275	histidine kinase; Provisional; Region: PRK13557
179408012276	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012277	putative active site [active]
179408012278	heme pocket [chemical binding]; other site
179408012279	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408012280	dimer interface [polypeptide binding]; other site
179408012281	phosphorylation site [posttranslational modification]
179408012282	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408012283	ATP binding site [chemical binding]; other site
179408012284	Mg2+ binding site [ion binding]; other site
179408012285	G-X-G motif; other site
179408012286	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012287	active site
179408012288	phosphorylation site [posttranslational modification]
179408012289	intermolecular recognition site; other site
179408012290	dimerization interface [polypeptide binding]; other site
179408012291	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408012292	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012293	active site
179408012294	phosphorylation site [posttranslational modification]
179408012295	intermolecular recognition site; other site
179408012296	MASE1; Region: MASE1; pfam05231
179408012297	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012298	PAS fold; Region: PAS_3; pfam08447
179408012299	putative active site [active]
179408012300	heme pocket [chemical binding]; other site
179408012301	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
179408012302	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012303	putative active site [active]
179408012304	heme pocket [chemical binding]; other site
179408012305	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408012306	dimer interface [polypeptide binding]; other site
179408012307	phosphorylation site [posttranslational modification]
179408012308	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408012309	ATP binding site [chemical binding]; other site
179408012310	Mg2+ binding site [ion binding]; other site
179408012311	G-X-G motif; other site
179408012312	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
179408012313	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
179408012314	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
179408012315	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
179408012316	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408012317	putative active site [active]
179408012318	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
179408012319	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
179408012320	putative active site [active]
179408012321	substrate binding site [chemical binding]; other site
179408012322	putative cosubstrate binding site; other site
179408012323	catalytic site [active]
179408012324	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
179408012325	substrate binding site [chemical binding]; other site
179408012326	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
179408012327	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
179408012328	active site
179408012329	metal binding site [ion binding]; metal-binding site
179408012330	DNA binding site [nucleotide binding]
179408012331	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408012332	putative active site [active]
179408012333	ATP-dependent DNA ligase [DNA replication, recombination, and repair]; Region: CDC9; COG1793
179408012334	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015
179408012335	active site
179408012336	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
179408012337	DNA binding site [nucleotide binding]
179408012338	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
179408012339	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
179408012340	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
179408012341	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
179408012342	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
179408012343	Protein kinase domain; Region: Pkinase; pfam00069
179408012344	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408012345	active site
179408012346	ATP binding site [chemical binding]; other site
179408012347	substrate binding site [chemical binding]; other site
179408012348	activation loop (A-loop); other site
179408012349	AAA ATPase domain; Region: AAA_16; pfam13191
179408012350	Predicted ATPase [General function prediction only]; Region: COG3899
179408012351	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408012352	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408012353	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408012354	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408012355	ATP binding site [chemical binding]; other site
179408012356	Mg2+ binding site [ion binding]; other site
179408012357	G-X-G motif; other site
179408012358	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408012359	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
179408012360	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
179408012361	dephospho-CoA kinase; Region: TIGR00152
179408012362	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
179408012363	CoA-binding site [chemical binding]; other site
179408012364	ATP-binding [chemical binding]; other site
179408012365	haemagglutination activity domain; Region: Haemagg_act; pfam05860
179408012366	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
179408012367	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
179408012368	PAS domain S-box; Region: sensory_box; TIGR00229
179408012369	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012370	putative active site [active]
179408012371	heme pocket [chemical binding]; other site
179408012372	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012373	PAS domain; Region: PAS_9; pfam13426
179408012374	putative active site [active]
179408012375	heme pocket [chemical binding]; other site
179408012376	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012377	PAS fold; Region: PAS_3; pfam08447
179408012378	putative active site [active]
179408012379	heme pocket [chemical binding]; other site
179408012380	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408012381	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408012382	dimer interface [polypeptide binding]; other site
179408012383	phosphorylation site [posttranslational modification]
179408012384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408012385	ATP binding site [chemical binding]; other site
179408012386	Mg2+ binding site [ion binding]; other site
179408012387	G-X-G motif; other site
179408012388	Response regulator receiver domain; Region: Response_reg; pfam00072
179408012389	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012390	active site
179408012391	phosphorylation site [posttranslational modification]
179408012392	intermolecular recognition site; other site
179408012393	dimerization interface [polypeptide binding]; other site
179408012394	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408012395	putative active site [active]
179408012396	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408012397	putative active site [active]
179408012398	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
179408012399	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012400	binding surface
179408012401	TPR motif; other site
179408012402	TPR repeat; Region: TPR_11; pfam13414
179408012403	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
179408012404	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
179408012405	TPR repeat; Region: TPR_11; pfam13414
179408012406	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012407	binding surface
179408012408	TPR motif; other site
179408012409	TPR repeat; Region: TPR_11; pfam13414
179408012410	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
179408012411	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
179408012412	active site
179408012413	SAM binding site [chemical binding]; other site
179408012414	homodimer interface [polypeptide binding]; other site
179408012415	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
179408012416	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
179408012417	active site
179408012418	Methyltransferase domain; Region: Methyltransf_24; pfam13578
179408012419	Methyltransferase domain; Region: Methyltransf_23; pfam13489
179408012420	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408012421	S-adenosylmethionine binding site [chemical binding]; other site
179408012422	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
179408012423	active site
179408012424	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
179408012425	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012426	binding surface
179408012427	TPR motif; other site
179408012428	Tetratricopeptide repeat; Region: TPR_1; pfam00515
179408012429	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012430	binding surface
179408012431	TPR motif; other site
179408012432	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
179408012433	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012434	binding surface
179408012435	TPR motif; other site
179408012436	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408012437	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012438	binding surface
179408012439	TPR motif; other site
179408012440	TPR repeat; Region: TPR_11; pfam13414
179408012441	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012442	binding surface
179408012443	TPR repeat; Region: TPR_11; pfam13414
179408012444	TPR motif; other site
179408012445	Tetratricopeptide repeat; Region: TPR_16; pfam13432
179408012446	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
179408012447	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
179408012448	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012449	binding surface
179408012450	TPR motif; other site
179408012451	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012452	binding surface
179408012453	TPR motif; other site
179408012454	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012455	binding surface
179408012456	TPR motif; other site
179408012457	TPR repeat; Region: TPR_11; pfam13414
179408012458	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
179408012459	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012460	binding surface
179408012461	TPR motif; other site
179408012462	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
179408012463	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012464	binding surface
179408012465	TPR motif; other site
179408012466	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012467	binding surface
179408012468	TPR motif; other site
179408012469	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
179408012470	TPR repeat; Region: TPR_11; pfam13414
179408012471	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408012472	binding surface
179408012473	TPR motif; other site
179408012474	TPR repeat; Region: TPR_11; pfam13414
179408012475	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
179408012476	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408012477	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
179408012478	tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887
179408012479	UbiA prenyltransferase family; Region: UbiA; pfam01040
179408012480	tocopherol O-methyltransferase; Region: PLN02244
179408012481	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408012482	S-adenosylmethionine binding site [chemical binding]; other site
179408012483	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
179408012484	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
179408012485	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
179408012486	TrkA-N domain; Region: TrkA_N; pfam02254
179408012487	TrkA-C domain; Region: TrkA_C; pfam02080
179408012488	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
179408012489	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
179408012490	Moco binding site; other site
179408012491	metal coordination site [ion binding]; other site
179408012492	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
179408012493	DDE superfamily endonuclease; Region: DDE_3; pfam13358
179408012494	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
179408012495	Mechanosensitive ion channel; Region: MS_channel; pfam00924
179408012496	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
179408012497	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
179408012498	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
179408012499	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
179408012500	homotetramer interface [polypeptide binding]; other site
179408012501	ligand binding site [chemical binding]; other site
179408012502	catalytic site [active]
179408012503	NAD binding site [chemical binding]; other site
179408012504	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
179408012505	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
179408012506	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
179408012507	isocitrate dehydrogenase; Validated; Region: PRK07362
179408012508	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
179408012509	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
179408012510	C-terminal domain interface [polypeptide binding]; other site
179408012511	GSH binding site (G-site) [chemical binding]; other site
179408012512	dimer interface [polypeptide binding]; other site
179408012513	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
179408012514	N-terminal domain interface [polypeptide binding]; other site
179408012515	putative dimer interface [polypeptide binding]; other site
179408012516	active site
179408012517	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
179408012518	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
179408012519	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
179408012520	P loop; other site
179408012521	Nucleotide binding site [chemical binding]; other site
179408012522	DTAP/Switch II; other site
179408012523	Switch I; other site
179408012524	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
179408012525	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
179408012526	Protein of unknown function (DUF497); Region: DUF497; cl01108
179408012527	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779
179408012528	Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077
179408012529	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
179408012530	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
179408012531	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
179408012532	Protein of unknown function (DUF433); Region: DUF433; cl01030
179408012533	DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096
179408012534	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012535	active site
179408012536	phosphorylation site [posttranslational modification]
179408012537	intermolecular recognition site; other site
179408012538	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012539	PAS fold; Region: PAS_3; pfam08447
179408012540	putative active site [active]
179408012541	heme pocket [chemical binding]; other site
179408012542	PAS domain S-box; Region: sensory_box; TIGR00229
179408012543	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408012544	dimer interface [polypeptide binding]; other site
179408012545	phosphorylation site [posttranslational modification]
179408012546	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408012547	ATP binding site [chemical binding]; other site
179408012548	Mg2+ binding site [ion binding]; other site
179408012549	G-X-G motif; other site
179408012550	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012551	active site
179408012552	phosphorylation site [posttranslational modification]
179408012553	intermolecular recognition site; other site
179408012554	dimerization interface [polypeptide binding]; other site
179408012555	Response regulator receiver domain; Region: Response_reg; pfam00072
179408012556	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012557	active site
179408012558	phosphorylation site [posttranslational modification]
179408012559	intermolecular recognition site; other site
179408012560	dimerization interface [polypeptide binding]; other site
179408012561	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
179408012562	putative binding surface; other site
179408012563	active site
179408012564	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408012565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012566	active site
179408012567	phosphorylation site [posttranslational modification]
179408012568	intermolecular recognition site; other site
179408012569	dimerization interface [polypeptide binding]; other site
179408012570	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
179408012571	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
179408012572	ATP binding site [chemical binding]; other site
179408012573	active site
179408012574	substrate binding site [chemical binding]; other site
179408012575	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
179408012576	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
179408012577	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
179408012578	Surface antigen; Region: Bac_surface_Ag; pfam01103
179408012579	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
179408012580	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
179408012581	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
179408012582	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
179408012583	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
179408012584	active site
179408012585	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408012586	putative active site [active]
179408012587	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
179408012588	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
179408012589	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
179408012590	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
179408012591	cofactor binding site; other site
179408012592	DNA binding site [nucleotide binding]
179408012593	substrate interaction site [chemical binding]; other site
179408012594	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
179408012595	BON domain; Region: BON; cl02771
179408012596	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
179408012597	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
179408012598	hypothetical protein; Reviewed; Region: PRK09588
179408012599	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
179408012600	TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950
179408012601	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
179408012602	catalytic residues [active]
179408012603	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
179408012604	4Fe-4S binding domain; Region: Fer4; pfam00037
179408012605	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
179408012606	shikimate kinase; Reviewed; Region: aroK; PRK00131
179408012607	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
179408012608	ADP binding site [chemical binding]; other site
179408012609	magnesium binding site [ion binding]; other site
179408012610	putative shikimate binding site; other site
179408012611	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
179408012612	aromatic acid decarboxylase; Validated; Region: PRK05920
179408012613	Flavoprotein; Region: Flavoprotein; pfam02441
179408012614	Exoribonuclease R [Transcription]; Region: VacB; COG0557
179408012615	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
179408012616	RNB domain; Region: RNB; pfam00773
179408012617	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
179408012618	RNA binding site [nucleotide binding]; other site
179408012619	Clp protease; Region: CLP_protease; pfam00574
179408012620	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
179408012621	oligomer interface [polypeptide binding]; other site
179408012622	active site residues [active]
179408012623	Protein of unknown function (DUF433); Region: DUF433; cl01030
179408012624	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
179408012625	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408012626	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012627	active site
179408012628	phosphorylation site [posttranslational modification]
179408012629	intermolecular recognition site; other site
179408012630	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
179408012631	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
179408012632	cyclase homology domain; Region: CHD; cd07302
179408012633	nucleotidyl binding site; other site
179408012634	metal binding site [ion binding]; metal-binding site
179408012635	dimer interface [polypeptide binding]; other site
179408012636	Protein kinase domain; Region: Pkinase; pfam00069
179408012637	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408012638	active site
179408012639	ATP binding site [chemical binding]; other site
179408012640	substrate binding site [chemical binding]; other site
179408012641	activation loop (A-loop); other site
179408012642	AAA ATPase domain; Region: AAA_16; pfam13191
179408012643	Predicted ATPase [General function prediction only]; Region: COG3899
179408012644	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408012645	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408012646	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408012647	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408012648	ATP binding site [chemical binding]; other site
179408012649	Mg2+ binding site [ion binding]; other site
179408012650	G-X-G motif; other site
179408012651	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
179408012652	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
179408012653	active site
179408012654	motif I; other site
179408012655	motif II; other site
179408012656	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
179408012657	hydrolase, alpha/beta fold family protein; Region: PLN02824
179408012658	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
179408012659	Response regulator receiver domain; Region: Response_reg; pfam00072
179408012660	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012661	active site
179408012662	phosphorylation site [posttranslational modification]
179408012663	intermolecular recognition site; other site
179408012664	dimerization interface [polypeptide binding]; other site
179408012665	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408012666	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408012667	PAS domain S-box; Region: sensory_box; TIGR00229
179408012668	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012669	putative active site [active]
179408012670	heme pocket [chemical binding]; other site
179408012671	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
179408012672	cyclase homology domain; Region: CHD; cd07302
179408012673	nucleotidyl binding site; other site
179408012674	metal binding site [ion binding]; metal-binding site
179408012675	dimer interface [polypeptide binding]; other site
179408012676	Response regulator receiver domain; Region: Response_reg; pfam00072
179408012677	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012678	active site
179408012679	phosphorylation site [posttranslational modification]
179408012680	intermolecular recognition site; other site
179408012681	dimerization interface [polypeptide binding]; other site
179408012682	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012683	PAS fold; Region: PAS_3; pfam08447
179408012684	putative active site [active]
179408012685	heme pocket [chemical binding]; other site
179408012686	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408012687	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408012688	PAS fold; Region: PAS_4; pfam08448
179408012689	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012690	putative active site [active]
179408012691	heme pocket [chemical binding]; other site
179408012692	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408012693	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012694	putative active site [active]
179408012695	heme pocket [chemical binding]; other site
179408012696	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012697	putative active site [active]
179408012698	heme pocket [chemical binding]; other site
179408012699	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408012700	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408012701	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408012702	dimer interface [polypeptide binding]; other site
179408012703	phosphorylation site [posttranslational modification]
179408012704	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408012705	ATP binding site [chemical binding]; other site
179408012706	Mg2+ binding site [ion binding]; other site
179408012707	G-X-G motif; other site
179408012708	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408012709	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012710	active site
179408012711	phosphorylation site [posttranslational modification]
179408012712	intermolecular recognition site; other site
179408012713	dimerization interface [polypeptide binding]; other site
179408012714	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
179408012715	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
179408012716	putative active site [active]
179408012717	Zn binding site [ion binding]; other site
179408012718	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408012719	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
179408012720	Probable Catalytic site; other site
179408012721	metal-binding site
179408012722	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
179408012723	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
179408012724	trimer interface [polypeptide binding]; other site
179408012725	active site
179408012726	substrate binding site [chemical binding]; other site
179408012727	CoA binding site [chemical binding]; other site
179408012728	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
179408012729	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
179408012730	trimer interface [polypeptide binding]; other site
179408012731	active site
179408012732	substrate binding site [chemical binding]; other site
179408012733	CoA binding site [chemical binding]; other site
179408012734	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
179408012735	trimer interface [polypeptide binding]; other site
179408012736	active site
179408012737	substrate binding site [chemical binding]; other site
179408012738	CoA binding site [chemical binding]; other site
179408012739	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
179408012740	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408012741	active site
179408012742	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
179408012743	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408012744	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408012745	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
179408012746	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
179408012747	Ycf46; Provisional; Region: ycf46; CHL00195
179408012748	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408012749	Walker A motif; other site
179408012750	ATP binding site [chemical binding]; other site
179408012751	Walker B motif; other site
179408012752	arginine finger; other site
179408012753	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
179408012754	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408012755	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
179408012756	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408012757	putative active site [active]
179408012758	putative NTP binding site [chemical binding]; other site
179408012759	putative nucleic acid binding site [nucleotide binding]; other site
179408012760	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408012761	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408012762	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408012763	active site
179408012764	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
179408012765	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
179408012766	substrate binding pocket [chemical binding]; other site
179408012767	chain length determination region; other site
179408012768	substrate-Mg2+ binding site; other site
179408012769	catalytic residues [active]
179408012770	aspartate-rich region 1; other site
179408012771	active site lid residues [active]
179408012772	aspartate-rich region 2; other site
179408012773	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
179408012774	FOG: CBS domain [General function prediction only]; Region: COG0517
179408012775	FOG: CBS domain [General function prediction only]; Region: COG0517
179408012776	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
179408012777	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
179408012778	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408012779	dimer interface [polypeptide binding]; other site
179408012780	phosphorylation site [posttranslational modification]
179408012781	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408012782	ATP binding site [chemical binding]; other site
179408012783	Mg2+ binding site [ion binding]; other site
179408012784	G-X-G motif; other site
179408012785	Response regulator receiver domain; Region: Response_reg; pfam00072
179408012786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012787	active site
179408012788	phosphorylation site [posttranslational modification]
179408012789	intermolecular recognition site; other site
179408012790	dimerization interface [polypeptide binding]; other site
179408012791	Response regulator receiver domain; Region: Response_reg; pfam00072
179408012792	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012793	active site
179408012794	phosphorylation site [posttranslational modification]
179408012795	intermolecular recognition site; other site
179408012796	dimerization interface [polypeptide binding]; other site
179408012797	PAS domain S-box; Region: sensory_box; TIGR00229
179408012798	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012799	putative active site [active]
179408012800	heme pocket [chemical binding]; other site
179408012801	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408012802	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012803	putative active site [active]
179408012804	heme pocket [chemical binding]; other site
179408012805	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
179408012806	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012807	putative active site [active]
179408012808	heme pocket [chemical binding]; other site
179408012809	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408012810	dimer interface [polypeptide binding]; other site
179408012811	phosphorylation site [posttranslational modification]
179408012812	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408012813	ATP binding site [chemical binding]; other site
179408012814	Mg2+ binding site [ion binding]; other site
179408012815	G-X-G motif; other site
179408012816	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408012817	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012818	active site
179408012819	phosphorylation site [posttranslational modification]
179408012820	intermolecular recognition site; other site
179408012821	dimerization interface [polypeptide binding]; other site
179408012822	Response regulator receiver domain; Region: Response_reg; pfam00072
179408012823	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012824	active site
179408012825	phosphorylation site [posttranslational modification]
179408012826	intermolecular recognition site; other site
179408012827	dimerization interface [polypeptide binding]; other site
179408012828	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408012829	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408012830	dimer interface [polypeptide binding]; other site
179408012831	phosphorylation site [posttranslational modification]
179408012832	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408012833	ATP binding site [chemical binding]; other site
179408012834	Mg2+ binding site [ion binding]; other site
179408012835	G-X-G motif; other site
179408012836	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408012837	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012838	active site
179408012839	phosphorylation site [posttranslational modification]
179408012840	intermolecular recognition site; other site
179408012841	dimerization interface [polypeptide binding]; other site
179408012842	Response regulator receiver domain; Region: Response_reg; pfam00072
179408012843	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012844	active site
179408012845	phosphorylation site [posttranslational modification]
179408012846	intermolecular recognition site; other site
179408012847	dimerization interface [polypeptide binding]; other site
179408012848	PAS domain S-box; Region: sensory_box; TIGR00229
179408012849	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012850	putative active site [active]
179408012851	heme pocket [chemical binding]; other site
179408012852	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408012853	dimer interface [polypeptide binding]; other site
179408012854	phosphorylation site [posttranslational modification]
179408012855	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408012856	ATP binding site [chemical binding]; other site
179408012857	Mg2+ binding site [ion binding]; other site
179408012858	G-X-G motif; other site
179408012859	Response regulator receiver domain; Region: Response_reg; pfam00072
179408012860	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012861	active site
179408012862	phosphorylation site [posttranslational modification]
179408012863	intermolecular recognition site; other site
179408012864	dimerization interface [polypeptide binding]; other site
179408012865	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
179408012866	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408012867	active site
179408012868	dimerization interface [polypeptide binding]; other site
179408012869	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408012870	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408012871	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408012872	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408012873	metal binding site [ion binding]; metal-binding site
179408012874	active site
179408012875	I-site; other site
179408012876	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408012877	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012878	active site
179408012879	phosphorylation site [posttranslational modification]
179408012880	intermolecular recognition site; other site
179408012881	dimerization interface [polypeptide binding]; other site
179408012882	PAS domain S-box; Region: sensory_box; TIGR00229
179408012883	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012884	putative active site [active]
179408012885	heme pocket [chemical binding]; other site
179408012886	PAS fold; Region: PAS_4; pfam08448
179408012887	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012888	putative active site [active]
179408012889	heme pocket [chemical binding]; other site
179408012890	PAS domain S-box; Region: sensory_box; TIGR00229
179408012891	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012892	putative active site [active]
179408012893	heme pocket [chemical binding]; other site
179408012894	PAS domain S-box; Region: sensory_box; TIGR00229
179408012895	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012896	putative active site [active]
179408012897	heme pocket [chemical binding]; other site
179408012898	PAS fold; Region: PAS_3; pfam08447
179408012899	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012900	putative active site [active]
179408012901	heme pocket [chemical binding]; other site
179408012902	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012903	putative active site [active]
179408012904	PAS fold; Region: PAS_3; pfam08447
179408012905	heme pocket [chemical binding]; other site
179408012906	PAS fold; Region: PAS_3; pfam08447
179408012907	PAS domain S-box; Region: sensory_box; TIGR00229
179408012908	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012909	putative active site [active]
179408012910	heme pocket [chemical binding]; other site
179408012911	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408012912	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408012913	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408012914	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408012915	dimer interface [polypeptide binding]; other site
179408012916	phosphorylation site [posttranslational modification]
179408012917	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408012918	ATP binding site [chemical binding]; other site
179408012919	Mg2+ binding site [ion binding]; other site
179408012920	G-X-G motif; other site
179408012921	Response regulator receiver domain; Region: Response_reg; pfam00072
179408012922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012923	active site
179408012924	phosphorylation site [posttranslational modification]
179408012925	intermolecular recognition site; other site
179408012926	dimerization interface [polypeptide binding]; other site
179408012927	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408012928	ATP binding site [chemical binding]; other site
179408012929	Mg2+ binding site [ion binding]; other site
179408012930	G-X-G motif; other site
179408012931	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408012932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012933	active site
179408012934	phosphorylation site [posttranslational modification]
179408012935	intermolecular recognition site; other site
179408012936	dimerization interface [polypeptide binding]; other site
179408012937	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012938	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408012939	putative active site [active]
179408012940	heme pocket [chemical binding]; other site
179408012941	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012942	putative active site [active]
179408012943	heme pocket [chemical binding]; other site
179408012944	PAS domain S-box; Region: sensory_box; TIGR00229
179408012945	PAS domain S-box; Region: sensory_box; TIGR00229
179408012946	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012947	putative active site [active]
179408012948	heme pocket [chemical binding]; other site
179408012949	PAS fold; Region: PAS_4; pfam08448
179408012950	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012951	putative active site [active]
179408012952	heme pocket [chemical binding]; other site
179408012953	PAS domain; Region: PAS_9; pfam13426
179408012954	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012955	putative active site [active]
179408012956	heme pocket [chemical binding]; other site
179408012957	PAS fold; Region: PAS_3; pfam08447
179408012958	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012959	putative active site [active]
179408012960	heme pocket [chemical binding]; other site
179408012961	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408012962	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408012963	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012964	PAS fold; Region: PAS_3; pfam08447
179408012965	putative active site [active]
179408012966	heme pocket [chemical binding]; other site
179408012967	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408012968	PAS domain; Region: PAS_9; pfam13426
179408012969	putative active site [active]
179408012970	heme pocket [chemical binding]; other site
179408012971	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408012972	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408012973	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408012974	dimer interface [polypeptide binding]; other site
179408012975	phosphorylation site [posttranslational modification]
179408012976	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
179408012977	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408012978	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408012979	ATP binding site [chemical binding]; other site
179408012980	G-X-G motif; other site
179408012981	Response regulator receiver domain; Region: Response_reg; pfam00072
179408012982	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408012983	active site
179408012984	phosphorylation site [posttranslational modification]
179408012985	intermolecular recognition site; other site
179408012986	dimerization interface [polypeptide binding]; other site
179408012987	phosphoenolpyruvate synthase; Validated; Region: PRK06464
179408012988	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
179408012989	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
179408012990	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
179408012991	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
179408012992	legume lectins; Region: lectin_L-type; cl14058
179408012993	homotetramer interaction site [polypeptide binding]; other site
179408012994	carbohydrate binding site [chemical binding]; other site
179408012995	metal binding site [ion binding]; metal-binding site
179408012996	Domain of unknown function DUF11; Region: DUF11; cl17728
179408012997	Domain of unknown function DUF11; Region: DUF11; pfam01345
179408012998	Domain of unknown function DUF11; Region: DUF11; pfam01345
179408012999	Domain of unknown function DUF11; Region: DUF11; pfam01345
179408013000	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408013001	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408013002	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
179408013003	legume lectins; Region: lectin_L-type; cl14058
179408013004	homotetramer interaction site [polypeptide binding]; other site
179408013005	carbohydrate binding site [chemical binding]; other site
179408013006	metal binding site [ion binding]; metal-binding site
179408013007	Domain of unknown function DUF11; Region: DUF11; pfam01345
179408013008	Domain of unknown function DUF11; Region: DUF11; pfam01345
179408013009	Domain of unknown function DUF11; Region: DUF11; pfam01345
179408013010	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408013011	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
179408013012	dimer interface [polypeptide binding]; other site
179408013013	ADP-ribose binding site [chemical binding]; other site
179408013014	active site
179408013015	nudix motif; other site
179408013016	metal binding site [ion binding]; metal-binding site
179408013017	AMIN domain; Region: AMIN; pfam11741
179408013018	Protein of unknown function (DUF3172); Region: DUF3172; pfam11371
179408013019	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
179408013020	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
179408013021	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
179408013022	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
179408013023	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
179408013024	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
179408013025	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
179408013026	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
179408013027	Antitoxin ParD; Region: ParD; pfam09386
179408013028	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
179408013029	Family description; Region: UvrD_C_2; pfam13538
179408013030	elongation factor G; Reviewed; Region: PRK00007
179408013031	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
179408013032	G1 box; other site
179408013033	putative GEF interaction site [polypeptide binding]; other site
179408013034	GTP/Mg2+ binding site [chemical binding]; other site
179408013035	Switch I region; other site
179408013036	G2 box; other site
179408013037	G3 box; other site
179408013038	Switch II region; other site
179408013039	G4 box; other site
179408013040	G5 box; other site
179408013041	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
179408013042	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
179408013043	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
179408013044	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
179408013045	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
179408013046	generic binding surface II; other site
179408013047	ssDNA binding site; other site
179408013048	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
179408013049	ATP binding site [chemical binding]; other site
179408013050	putative Mg++ binding site [ion binding]; other site
179408013051	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
179408013052	nucleotide binding region [chemical binding]; other site
179408013053	ATP-binding site [chemical binding]; other site
179408013054	elongation factor Ts; Reviewed; Region: tsf; PRK12332
179408013055	UBA/TS-N domain; Region: UBA; pfam00627
179408013056	Elongation factor TS; Region: EF_TS; pfam00889
179408013057	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
179408013058	rRNA interaction site [nucleotide binding]; other site
179408013059	S8 interaction site; other site
179408013060	putative laminin-1 binding site; other site
179408013061	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
179408013062	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
179408013063	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
179408013064	Ligand Binding Site [chemical binding]; other site
179408013065	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
179408013066	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
179408013067	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
179408013068	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
179408013069	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
179408013070	ligand binding site [chemical binding]; other site
179408013071	Domain of unknown function DUF20; Region: UPF0118; pfam01594
179408013072	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
179408013073	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
179408013074	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
179408013075	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
179408013076	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
179408013077	active site
179408013078	HIGH motif; other site
179408013079	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
179408013080	KMSKS motif; other site
179408013081	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
179408013082	tRNA binding surface [nucleotide binding]; other site
179408013083	anticodon binding site; other site
179408013084	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
179408013085	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
179408013086	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
179408013087	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
179408013088	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408013089	dimer interface [polypeptide binding]; other site
179408013090	conserved gate region; other site
179408013091	putative PBP binding loops; other site
179408013092	ABC-ATPase subunit interface; other site
179408013093	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
179408013094	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408013095	ABC-ATPase subunit interface; other site
179408013096	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
179408013097	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
179408013098	Walker A/P-loop; other site
179408013099	ATP binding site [chemical binding]; other site
179408013100	Q-loop/lid; other site
179408013101	ABC transporter signature motif; other site
179408013102	Walker B; other site
179408013103	D-loop; other site
179408013104	H-loop/switch region; other site
179408013105	TOBE domain; Region: TOBE_2; pfam08402
179408013106	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
179408013107	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
179408013108	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
179408013109	Walker A/P-loop; other site
179408013110	ATP binding site [chemical binding]; other site
179408013111	Q-loop/lid; other site
179408013112	ABC transporter signature motif; other site
179408013113	Walker B; other site
179408013114	D-loop; other site
179408013115	H-loop/switch region; other site
179408013116	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
179408013117	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
179408013118	Walker A/P-loop; other site
179408013119	ATP binding site [chemical binding]; other site
179408013120	Q-loop/lid; other site
179408013121	ABC transporter signature motif; other site
179408013122	Walker B; other site
179408013123	D-loop; other site
179408013124	H-loop/switch region; other site
179408013125	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
179408013126	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013127	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408013128	putative active site [active]
179408013129	heme pocket [chemical binding]; other site
179408013130	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013131	putative active site [active]
179408013132	heme pocket [chemical binding]; other site
179408013133	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408013134	GAF domain; Region: GAF; pfam01590
179408013135	PAS domain; Region: PAS; smart00091
179408013136	PAS fold; Region: PAS_4; pfam08448
179408013137	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408013138	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408013139	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408013140	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
179408013141	dimer interface [polypeptide binding]; other site
179408013142	phosphorylation site [posttranslational modification]
179408013143	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408013144	ATP binding site [chemical binding]; other site
179408013145	Mg2+ binding site [ion binding]; other site
179408013146	G-X-G motif; other site
179408013147	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
179408013148	Cytochrome P450; Region: p450; cl12078
179408013149	Protein of unknown function (DUF98); Region: DUF98; pfam01947
179408013150	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
179408013151	XisI protein; Region: XisI; pfam08869
179408013152	XisH protein; Region: XisH; pfam08814
179408013153	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
179408013154	Cupin domain; Region: Cupin_2; cl17218
179408013155	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
179408013156	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
179408013157	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
179408013158	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
179408013159	putative metal binding site [ion binding]; other site
179408013160	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408013161	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
179408013162	putative ADP-binding pocket [chemical binding]; other site
179408013163	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
179408013164	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408013165	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
179408013166	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408013167	active site
179408013168	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
179408013169	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317
179408013170	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
179408013171	active site
179408013172	substrate binding site [chemical binding]; other site
179408013173	metal binding site [ion binding]; metal-binding site
179408013174	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
179408013175	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408013176	S-adenosylmethionine binding site [chemical binding]; other site
179408013177	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
179408013178	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
179408013179	putative active site [active]
179408013180	oxyanion strand; other site
179408013181	catalytic triad [active]
179408013182	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
179408013183	putative substrate binding pocket [chemical binding]; other site
179408013184	AC domain interface; other site
179408013185	catalytic triad [active]
179408013186	AB domain interface; other site
179408013187	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
179408013188	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
179408013189	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
179408013190	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
179408013191	active site
179408013192	SAM binding site [chemical binding]; other site
179408013193	homodimer interface [polypeptide binding]; other site
179408013194	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
179408013195	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408013196	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408013197	Probable transposase; Region: OrfB_IS605; pfam01385
179408013198	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408013199	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457
179408013200	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408013201	FeS/SAM binding site; other site
179408013202	Methyltransferase domain; Region: Methyltransf_23; pfam13489
179408013203	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408013204	S-adenosylmethionine binding site [chemical binding]; other site
179408013205	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
179408013206	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
179408013207	active site
179408013208	substrate binding site [chemical binding]; other site
179408013209	cosubstrate binding site; other site
179408013210	catalytic site [active]
179408013211	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
179408013212	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
179408013213	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
179408013214	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408013215	dimer interface [polypeptide binding]; other site
179408013216	conserved gate region; other site
179408013217	putative PBP binding loops; other site
179408013218	ABC-ATPase subunit interface; other site
179408013219	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
179408013220	conserved cys residue [active]
179408013221	PsaX family; Region: PsaX; pfam08078
179408013222	lipoyl synthase; Provisional; Region: PRK12928
179408013223	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408013224	FeS/SAM binding site; other site
179408013225	Response regulator receiver domain; Region: Response_reg; pfam00072
179408013226	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408013227	active site
179408013228	phosphorylation site [posttranslational modification]
179408013229	intermolecular recognition site; other site
179408013230	dimerization interface [polypeptide binding]; other site
179408013231	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
179408013232	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
179408013233	putative ribose interaction site [chemical binding]; other site
179408013234	putative ADP binding site [chemical binding]; other site
179408013235	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
179408013236	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
179408013237	putative active site [active]
179408013238	putative metal binding site [ion binding]; other site
179408013239	HEAT repeats; Region: HEAT_2; pfam13646
179408013240	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
179408013241	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408013242	putative ADP-binding pocket [chemical binding]; other site
179408013243	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
179408013244	active site
179408013245	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
179408013246	dimer interface [polypeptide binding]; other site
179408013247	catalytic triad [active]
179408013248	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
179408013249	substrate binding site [chemical binding]; other site
179408013250	active site
179408013251	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
179408013252	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
179408013253	NAD(P) binding site [chemical binding]; other site
179408013254	active site
179408013255	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
179408013256	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
179408013257	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408013258	FeS/SAM binding site; other site
179408013259	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
179408013260	heat shock protein HtpX; Provisional; Region: PRK03982
179408013261	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
179408013262	putative active site [active]
179408013263	homotetrameric interface [polypeptide binding]; other site
179408013264	metal binding site [ion binding]; metal-binding site
179408013265	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
179408013266	AAA ATPase domain; Region: AAA_16; pfam13191
179408013267	NACHT domain; Region: NACHT; pfam05729
179408013268	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
179408013269	FtsH Extracellular; Region: FtsH_ext; pfam06480
179408013270	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
179408013271	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408013272	Walker A motif; other site
179408013273	ATP binding site [chemical binding]; other site
179408013274	Walker B motif; other site
179408013275	arginine finger; other site
179408013276	Peptidase family M41; Region: Peptidase_M41; pfam01434
179408013277	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476
179408013278	Peptidase family M48; Region: Peptidase_M48; pfam01435
179408013279	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408013280	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408013281	dimer interface [polypeptide binding]; other site
179408013282	phosphorylation site [posttranslational modification]
179408013283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408013284	ATP binding site [chemical binding]; other site
179408013285	Mg2+ binding site [ion binding]; other site
179408013286	G-X-G motif; other site
179408013287	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
179408013288	Protein of unknown function, DUF482; Region: DUF482; pfam04339
179408013289	RibD C-terminal domain; Region: RibD_C; cl17279
179408013290	RibD C-terminal domain; Region: RibD_C; cl17279
179408013291	DEAD/DEAH box helicase; Region: DEAD; pfam00270
179408013292	ATP binding site [chemical binding]; other site
179408013293	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
179408013294	photosystem I subunit IV; Reviewed; Region: psaE; CHL00125
179408013295	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945
179408013296	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
179408013297	DNA binding site [nucleotide binding]
179408013298	catalytic residue [active]
179408013299	H2TH interface [polypeptide binding]; other site
179408013300	putative catalytic residues [active]
179408013301	turnover-facilitating residue; other site
179408013302	intercalation triad [nucleotide binding]; other site
179408013303	8OG recognition residue [nucleotide binding]; other site
179408013304	putative reading head residues; other site
179408013305	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
179408013306	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
179408013307	Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910
179408013308	malate dehydrogenase; Reviewed; Region: PRK06223
179408013309	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
179408013310	NAD(P) binding site [chemical binding]; other site
179408013311	dimer interface [polypeptide binding]; other site
179408013312	tetramer (dimer of dimers) interface [polypeptide binding]; other site
179408013313	substrate binding site [chemical binding]; other site
179408013314	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408013315	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408013316	PAS fold; Region: PAS_4; pfam08448
179408013317	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013318	putative active site [active]
179408013319	heme pocket [chemical binding]; other site
179408013320	PAS domain S-box; Region: sensory_box; TIGR00229
179408013321	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013322	putative active site [active]
179408013323	heme pocket [chemical binding]; other site
179408013324	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013325	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408013326	putative active site [active]
179408013327	heme pocket [chemical binding]; other site
179408013328	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013329	putative active site [active]
179408013330	heme pocket [chemical binding]; other site
179408013331	PAS domain S-box; Region: sensory_box; TIGR00229
179408013332	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013333	putative active site [active]
179408013334	heme pocket [chemical binding]; other site
179408013335	PAS fold; Region: PAS_4; pfam08448
179408013336	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013337	putative active site [active]
179408013338	heme pocket [chemical binding]; other site
179408013339	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408013340	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408013341	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408013342	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408013343	dimer interface [polypeptide binding]; other site
179408013344	phosphorylation site [posttranslational modification]
179408013345	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408013346	ATP binding site [chemical binding]; other site
179408013347	Mg2+ binding site [ion binding]; other site
179408013348	G-X-G motif; other site
179408013349	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013350	PAS domain; Region: PAS_9; pfam13426
179408013351	putative active site [active]
179408013352	heme pocket [chemical binding]; other site
179408013353	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408013354	GAF domain; Region: GAF; pfam01590
179408013355	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013356	PAS domain; Region: PAS_9; pfam13426
179408013357	putative active site [active]
179408013358	heme pocket [chemical binding]; other site
179408013359	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408013360	GAF domain; Region: GAF; pfam01590
179408013361	PAS domain S-box; Region: sensory_box; TIGR00229
179408013362	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013363	putative active site [active]
179408013364	heme pocket [chemical binding]; other site
179408013365	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408013366	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408013367	metal binding site [ion binding]; metal-binding site
179408013368	active site
179408013369	I-site; other site
179408013370	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
179408013371	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
179408013372	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
179408013373	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
179408013374	substrate binding site [chemical binding]; other site
179408013375	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
179408013376	substrate binding site [chemical binding]; other site
179408013377	ligand binding site [chemical binding]; other site
179408013378	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
179408013379	putative active site [active]
179408013380	Cupin domain; Region: Cupin_2; cl17218
179408013381	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408013382	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408013383	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408013384	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
179408013385	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
179408013386	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
179408013387	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013388	PAS domain; Region: PAS_9; pfam13426
179408013389	putative active site [active]
179408013390	heme pocket [chemical binding]; other site
179408013391	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408013392	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013393	putative active site [active]
179408013394	heme pocket [chemical binding]; other site
179408013395	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013396	putative active site [active]
179408013397	heme pocket [chemical binding]; other site
179408013398	PAS fold; Region: PAS_4; pfam08448
179408013399	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013400	putative active site [active]
179408013401	heme pocket [chemical binding]; other site
179408013402	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013403	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408013404	putative active site [active]
179408013405	heme pocket [chemical binding]; other site
179408013406	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013407	putative active site [active]
179408013408	heme pocket [chemical binding]; other site
179408013409	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408013410	GAF domain; Region: GAF; pfam01590
179408013411	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408013412	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408013413	dimer interface [polypeptide binding]; other site
179408013414	phosphorylation site [posttranslational modification]
179408013415	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408013416	ATP binding site [chemical binding]; other site
179408013417	Mg2+ binding site [ion binding]; other site
179408013418	G-X-G motif; other site
179408013419	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408013420	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408013421	active site
179408013422	phosphorylation site [posttranslational modification]
179408013423	intermolecular recognition site; other site
179408013424	dimerization interface [polypeptide binding]; other site
179408013425	PAS domain; Region: PAS_9; pfam13426
179408013426	cyclase homology domain; Region: CHD; cd07302
179408013427	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
179408013428	nucleotidyl binding site; other site
179408013429	metal binding site [ion binding]; metal-binding site
179408013430	dimer interface [polypeptide binding]; other site
179408013431	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
179408013432	anti sigma factor interaction site; other site
179408013433	regulatory phosphorylation site [posttranslational modification]; other site
179408013434	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381
179408013435	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408013436	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408013437	Probable transposase; Region: OrfB_IS605; pfam01385
179408013438	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
179408013439	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
179408013440	Ligand Binding Site [chemical binding]; other site
179408013441	Uncharacterized conserved protein [Function unknown]; Region: COG0062
179408013442	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
179408013443	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
179408013444	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408013445	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408013446	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
179408013447	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
179408013448	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408013449	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408013450	tellurium resistance terB-like protein; Region: terB_like; cd07177
179408013451	metal binding site [ion binding]; metal-binding site
179408013452	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
179408013453	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
179408013454	PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990
179408013455	protein binding site [polypeptide binding]; other site
179408013456	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
179408013457	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
179408013458	ligand binding site [chemical binding]; other site
179408013459	flexible hinge region; other site
179408013460	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
179408013461	active site
179408013462	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
179408013463	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
179408013464	Probable transposase; Region: OrfB_IS605; pfam01385
179408013465	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408013466	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
179408013467	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408013468	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408013469	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
179408013470	putative active site [active]
179408013471	putative NTP binding site [chemical binding]; other site
179408013472	putative nucleic acid binding site [nucleotide binding]; other site
179408013473	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408013474	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408013475	active site
179408013476	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
179408013477	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408013478	Alpha amylase catalytic domain found in maltogenic amylases, cyclodextrin glycosyltransferase, and related proteins; Region: AmyAc_AmyMalt_CGTase_like; cd11320
179408013479	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
179408013480	Ca binding site [ion binding]; other site
179408013481	active site
179408013482	catalytic site [active]
179408013483	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
179408013484	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467
179408013485	starch-binding site 2 [chemical binding]; other site
179408013486	starch-binding site 1 [chemical binding]; other site
179408013487	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
179408013488	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
179408013489	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
179408013490	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
179408013491	Domain of unknown function DUF20; Region: UPF0118; pfam01594
179408013492	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
179408013493	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
179408013494	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
179408013495	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
179408013496	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
179408013497	Peptidase family M23; Region: Peptidase_M23; pfam01551
179408013498	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
179408013499	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
179408013500	dimer interface [polypeptide binding]; other site
179408013501	decamer (pentamer of dimers) interface [polypeptide binding]; other site
179408013502	catalytic triad [active]
179408013503	peroxidatic and resolving cysteines [active]
179408013504	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
179408013505	putative catalytic residues [active]
179408013506	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408013507	putative active site [active]
179408013508	Clp protease ATP binding subunit; Region: clpC; CHL00095
179408013509	Clp amino terminal domain; Region: Clp_N; pfam02861
179408013510	Clp amino terminal domain; Region: Clp_N; pfam02861
179408013511	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408013512	Walker A motif; other site
179408013513	ATP binding site [chemical binding]; other site
179408013514	Walker B motif; other site
179408013515	arginine finger; other site
179408013516	UvrB/uvrC motif; Region: UVR; pfam02151
179408013517	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408013518	Walker A motif; other site
179408013519	ATP binding site [chemical binding]; other site
179408013520	Walker B motif; other site
179408013521	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
179408013522	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
179408013523	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408013524	active site
179408013525	ATP binding site [chemical binding]; other site
179408013526	substrate binding site [chemical binding]; other site
179408013527	activation loop (A-loop); other site
179408013528	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
179408013529	AAA ATPase domain; Region: AAA_16; pfam13191
179408013530	Predicted ATPase [General function prediction only]; Region: COG3899
179408013531	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408013532	GAF domain; Region: GAF; pfam01590
179408013533	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408013534	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408013535	ATP binding site [chemical binding]; other site
179408013536	Mg2+ binding site [ion binding]; other site
179408013537	G-X-G motif; other site
179408013538	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
179408013539	Uncharacterized conserved protein [Function unknown]; Region: COG0432
179408013540	SOUL heme-binding protein; Region: SOUL; pfam04832
179408013541	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408013542	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408013543	active site
179408013544	phosphorylation site [posttranslational modification]
179408013545	intermolecular recognition site; other site
179408013546	dimerization interface [polypeptide binding]; other site
179408013547	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
179408013548	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
179408013549	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
179408013550	Transcriptional regulator [Transcription]; Region: LysR; COG0583
179408013551	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
179408013552	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
179408013553	putative dimerization interface [polypeptide binding]; other site
179408013554	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
179408013555	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
179408013556	Cadmium resistance transporter; Region: Cad; pfam03596
179408013557	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
179408013558	Cadmium resistance transporter; Region: Cad; pfam03596
179408013559	Domain of unknown function (DUF202); Region: DUF202; pfam02656
179408013560	Domain of unknown function (DUF202); Region: DUF202; cl09954
179408013561	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
179408013562	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
179408013563	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
179408013564	dimer interface [polypeptide binding]; other site
179408013565	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408013566	catalytic residue [active]
179408013567	Predicted transcriptional regulator [Transcription]; Region: COG1959
179408013568	Transcriptional regulator; Region: Rrf2; pfam02082
179408013569	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
179408013570	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
179408013571	ligand binding site [chemical binding]; other site
179408013572	flexible hinge region; other site
179408013573	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
179408013574	putative switch regulator; other site
179408013575	non-specific DNA interactions [nucleotide binding]; other site
179408013576	DNA binding site [nucleotide binding]
179408013577	sequence specific DNA binding site [nucleotide binding]; other site
179408013578	putative cAMP binding site [chemical binding]; other site
179408013579	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
179408013580	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
179408013581	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
179408013582	trimer interface [polypeptide binding]; other site
179408013583	active site
179408013584	substrate binding site [chemical binding]; other site
179408013585	CoA binding site [chemical binding]; other site
179408013586	CHASE domain; Region: CHASE; cl01369
179408013587	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408013588	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408013589	dimer interface [polypeptide binding]; other site
179408013590	phosphorylation site [posttranslational modification]
179408013591	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408013592	ATP binding site [chemical binding]; other site
179408013593	Mg2+ binding site [ion binding]; other site
179408013594	G-X-G motif; other site
179408013595	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
179408013596	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
179408013597	Walker A/P-loop; other site
179408013598	ATP binding site [chemical binding]; other site
179408013599	Q-loop/lid; other site
179408013600	ABC transporter signature motif; other site
179408013601	Walker B; other site
179408013602	D-loop; other site
179408013603	H-loop/switch region; other site
179408013604	TOBE-like domain; Region: TOBE_3; pfam12857
179408013605	glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317
179408013606	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
179408013607	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
179408013608	primosomal protein N' Region: priA; TIGR00595
179408013609	ATP binding site [chemical binding]; other site
179408013610	putative Mg++ binding site [ion binding]; other site
179408013611	helicase superfamily c-terminal domain; Region: HELICc; smart00490
179408013612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408013613	ATP binding site [chemical binding]; other site
179408013614	Mg2+ binding site [ion binding]; other site
179408013615	G-X-G motif; other site
179408013616	spermine synthase; Region: PLN02823
179408013617	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408013618	S-adenosylmethionine binding site [chemical binding]; other site
179408013619	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
179408013620	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
179408013621	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
179408013622	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
179408013623	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
179408013624	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408013625	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408013626	magnesium chelatase subunit H; Provisional; Region: PRK12493
179408013627	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
179408013628	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
179408013629	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
179408013630	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
179408013631	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
179408013632	oligomeric interface; other site
179408013633	putative active site [active]
179408013634	homodimer interface [polypeptide binding]; other site
179408013635	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
179408013636	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912
179408013637	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
179408013638	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408013639	non-specific DNA binding site [nucleotide binding]; other site
179408013640	salt bridge; other site
179408013641	sequence-specific DNA binding site [nucleotide binding]; other site
179408013642	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
179408013643	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
179408013644	oligomeric interface; other site
179408013645	putative active site [active]
179408013646	homodimer interface [polypeptide binding]; other site
179408013647	CTLH/CRA C-terminal to LisH motif domain; Region: CLTH; pfam10607
179408013648	Methyltransferase domain; Region: Methyltransf_11; pfam08241
179408013649	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
179408013650	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
179408013651	Ligand binding site; other site
179408013652	Putative Catalytic site; other site
179408013653	DXD motif; other site
179408013654	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
179408013655	FAD binding domain; Region: FAD_binding_4; pfam01565
179408013656	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
179408013657	PAS domain S-box; Region: sensory_box; TIGR00229
179408013658	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013659	putative active site [active]
179408013660	heme pocket [chemical binding]; other site
179408013661	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013662	PAS domain; Region: PAS_9; pfam13426
179408013663	putative active site [active]
179408013664	heme pocket [chemical binding]; other site
179408013665	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408013666	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408013667	dimer interface [polypeptide binding]; other site
179408013668	phosphorylation site [posttranslational modification]
179408013669	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408013670	ATP binding site [chemical binding]; other site
179408013671	Mg2+ binding site [ion binding]; other site
179408013672	G-X-G motif; other site
179408013673	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
179408013674	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
179408013675	purine monophosphate binding site [chemical binding]; other site
179408013676	dimer interface [polypeptide binding]; other site
179408013677	putative catalytic residues [active]
179408013678	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
179408013679	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
179408013680	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
179408013681	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
179408013682	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
179408013683	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
179408013684	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
179408013685	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
179408013686	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
179408013687	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
179408013688	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
179408013689	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
179408013690	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
179408013691	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
179408013692	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
179408013693	PemK-like protein; Region: PemK; pfam02452
179408013694	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
179408013695	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
179408013696	active site
179408013697	metal binding site [ion binding]; metal-binding site
179408013698	hexamer interface [polypeptide binding]; other site
179408013699	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
179408013700	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
179408013701	active site
179408013702	Na/Ca binding site [ion binding]; other site
179408013703	catalytic site [active]
179408013704	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
179408013705	classical (c) SDRs; Region: SDR_c; cd05233
179408013706	NAD(P) binding site [chemical binding]; other site
179408013707	active site
179408013708	FO synthase subunit 1; Reviewed; Region: cofG; PRK06245
179408013709	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408013710	FeS/SAM binding site; other site
179408013711	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
179408013712	protein I interface; other site
179408013713	D2 interface; other site
179408013714	protein T interface; other site
179408013715	chlorophyll binding site; other site
179408013716	beta carotene binding site; other site
179408013717	pheophytin binding site; other site
179408013718	manganese-stabilizing polypeptide interface; other site
179408013719	CP43 interface; other site
179408013720	protein L interface; other site
179408013721	oxygen evolving complex binding site; other site
179408013722	bromide binding site; other site
179408013723	quinone binding site; other site
179408013724	Fe binding site [ion binding]; other site
179408013725	core light harvesting interface; other site
179408013726	cytochrome b559 alpha subunit interface; other site
179408013727	cytochrome c-550 interface; other site
179408013728	protein J interface; other site
179408013729	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
179408013730	active site
179408013731	putative homodimer interface [polypeptide binding]; other site
179408013732	SAM binding site [chemical binding]; other site
179408013733	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
179408013734	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408013735	S-adenosylmethionine binding site [chemical binding]; other site
179408013736	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
179408013737	cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068
179408013738	ATP-grasp domain; Region: ATP-grasp_4; cl17255
179408013739	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
179408013740	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
179408013741	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
179408013742	proposed catalytic triad [active]
179408013743	active site nucleophile [active]
179408013744	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
179408013745	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
179408013746	homotrimer interaction site [polypeptide binding]; other site
179408013747	zinc binding site [ion binding]; other site
179408013748	CDP-binding sites; other site
179408013749	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
179408013750	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
179408013751	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
179408013752	AIR carboxylase; Region: AIRC; smart01001
179408013753	putative high light inducible protein; Region: PHA02337
179408013754	PsbP; Region: PsbP; pfam01789
179408013755	Maf-like protein; Region: Maf; pfam02545
179408013756	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
179408013757	active site
179408013758	dimer interface [polypeptide binding]; other site
179408013759	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408013760	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408013761	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
179408013762	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408013763	putative active site [active]
179408013764	putative NTP binding site [chemical binding]; other site
179408013765	putative nucleic acid binding site [nucleotide binding]; other site
179408013766	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408013767	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408013768	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408013769	active site
179408013770	enolase; Provisional; Region: eno; PRK00077
179408013771	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
179408013772	dimer interface [polypeptide binding]; other site
179408013773	metal binding site [ion binding]; metal-binding site
179408013774	substrate binding pocket [chemical binding]; other site
179408013775	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
179408013776	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
179408013777	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
179408013778	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
179408013779	Walker A/P-loop; other site
179408013780	ATP binding site [chemical binding]; other site
179408013781	Q-loop/lid; other site
179408013782	ABC transporter signature motif; other site
179408013783	Walker B; other site
179408013784	D-loop; other site
179408013785	H-loop/switch region; other site
179408013786	TOBE-like domain; Region: TOBE_3; pfam12857
179408013787	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
179408013788	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
179408013789	substrate binding site [chemical binding]; other site
179408013790	glutamase interaction surface [polypeptide binding]; other site
179408013791	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
179408013792	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
179408013793	phosphopeptide binding site; other site
179408013794	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
179408013795	cyclase homology domain; Region: CHD; cd07302
179408013796	nucleotidyl binding site; other site
179408013797	metal binding site [ion binding]; metal-binding site
179408013798	dimer interface [polypeptide binding]; other site
179408013799	photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515
179408013800	L-aspartate oxidase; Provisional; Region: PRK06175
179408013801	L-aspartate oxidase; Provisional; Region: PRK07395
179408013802	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
179408013803	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
179408013804	CHASE2 domain; Region: CHASE2; pfam05226
179408013805	PAS fold; Region: PAS_4; pfam08448
179408013806	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013807	putative active site [active]
179408013808	heme pocket [chemical binding]; other site
179408013809	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408013810	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408013811	metal binding site [ion binding]; metal-binding site
179408013812	active site
179408013813	I-site; other site
179408013814	Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916
179408013815	substrate binding site [chemical binding]; other site
179408013816	putative active site [active]
179408013817	redox center [active]
179408013818	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722
179408013819	phosphate binding site [ion binding]; other site
179408013820	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408013821	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408013822	Probable transposase; Region: OrfB_IS605; pfam01385
179408013823	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
179408013824	catalytic triad [active]
179408013825	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
179408013826	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
179408013827	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
179408013828	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
179408013829	phosphopeptide binding site; other site
179408013830	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
179408013831	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
179408013832	active site
179408013833	catalytic residues [active]
179408013834	metal binding site [ion binding]; metal-binding site
179408013835	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
179408013836	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
179408013837	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408013838	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408013839	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408013840	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
179408013841	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
179408013842	putative active site [active]
179408013843	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
179408013844	substrate binding site; other site
179408013845	dimer interface; other site
179408013846	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408013847	putative active site [active]
179408013848	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
179408013849	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
179408013850	NAD(P) binding site [chemical binding]; other site
179408013851	active site
179408013852	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
179408013853	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
179408013854	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
179408013855	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
179408013856	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
179408013857	Transcriptional regulator [Transcription]; Region: LysR; COG0583
179408013858	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
179408013859	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
179408013860	dimerization interface [polypeptide binding]; other site
179408013861	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408013862	binding surface
179408013863	TPR motif; other site
179408013864	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408013865	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408013866	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408013867	TPR motif; other site
179408013868	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408013869	binding surface
179408013870	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408013871	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408013872	binding surface
179408013873	TPR motif; other site
179408013874	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408013875	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
179408013876	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408013877	Coenzyme A binding pocket [chemical binding]; other site
179408013878	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
179408013879	cyclase homology domain; Region: CHD; cd07302
179408013880	nucleotidyl binding site; other site
179408013881	metal binding site [ion binding]; metal-binding site
179408013882	dimer interface [polypeptide binding]; other site
179408013883	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
179408013884	cyclase homology domain; Region: CHD; cd07302
179408013885	nucleotidyl binding site; other site
179408013886	metal binding site [ion binding]; metal-binding site
179408013887	dimer interface [polypeptide binding]; other site
179408013888	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
179408013889	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
179408013890	active site
179408013891	motif I; other site
179408013892	motif II; other site
179408013893	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408013894	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408013895	active site
179408013896	phosphorylation site [posttranslational modification]
179408013897	intermolecular recognition site; other site
179408013898	dimerization interface [polypeptide binding]; other site
179408013899	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408013900	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408013901	dimer interface [polypeptide binding]; other site
179408013902	phosphorylation site [posttranslational modification]
179408013903	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408013904	ATP binding site [chemical binding]; other site
179408013905	Mg2+ binding site [ion binding]; other site
179408013906	G-X-G motif; other site
179408013907	PAS domain; Region: PAS; smart00091
179408013908	PAS fold; Region: PAS_4; pfam08448
179408013909	putative active site [active]
179408013910	heme pocket [chemical binding]; other site
179408013911	PAS domain; Region: PAS_9; pfam13426
179408013912	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013913	putative active site [active]
179408013914	heme pocket [chemical binding]; other site
179408013915	PAS domain S-box; Region: sensory_box; TIGR00229
179408013916	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013917	putative active site [active]
179408013918	heme pocket [chemical binding]; other site
179408013919	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013920	PAS fold; Region: PAS_3; pfam08447
179408013921	putative active site [active]
179408013922	heme pocket [chemical binding]; other site
179408013923	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013924	PAS fold; Region: PAS_3; pfam08447
179408013925	putative active site [active]
179408013926	heme pocket [chemical binding]; other site
179408013927	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
179408013928	Histidine kinase; Region: HisKA_2; pfam07568
179408013929	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408013930	ATP binding site [chemical binding]; other site
179408013931	Mg2+ binding site [ion binding]; other site
179408013932	G-X-G motif; other site
179408013933	proline aminopeptidase P II; Provisional; Region: PRK10879
179408013934	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
179408013935	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
179408013936	active site
179408013937	cell division protein; Validated; Region: ftsH; CHL00176
179408013938	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408013939	Walker A motif; other site
179408013940	ATP binding site [chemical binding]; other site
179408013941	Walker B motif; other site
179408013942	arginine finger; other site
179408013943	Peptidase family M41; Region: Peptidase_M41; pfam01434
179408013944	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
179408013945	Mg binding site [ion binding]; other site
179408013946	nucleotide binding site [chemical binding]; other site
179408013947	putative protofilament interface [polypeptide binding]; other site
179408013948	Mg2+ transporter (mgtE); Region: mgtE; TIGR00400
179408013949	MgtE intracellular N domain; Region: MgtE_N; smart00924
179408013950	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
179408013951	Divalent cation transporter; Region: MgtE; pfam01769
179408013952	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
179408013953	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408013954	dimer interface [polypeptide binding]; other site
179408013955	conserved gate region; other site
179408013956	putative PBP binding loops; other site
179408013957	ABC-ATPase subunit interface; other site
179408013958	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408013959	dimer interface [polypeptide binding]; other site
179408013960	conserved gate region; other site
179408013961	putative PBP binding loops; other site
179408013962	ABC-ATPase subunit interface; other site
179408013963	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
179408013964	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
179408013965	Walker A/P-loop; other site
179408013966	ATP binding site [chemical binding]; other site
179408013967	Q-loop/lid; other site
179408013968	ABC transporter signature motif; other site
179408013969	Walker B; other site
179408013970	D-loop; other site
179408013971	H-loop/switch region; other site
179408013972	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
179408013973	CHASE domain; Region: CHASE; cl01369
179408013974	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013975	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408013976	putative active site [active]
179408013977	heme pocket [chemical binding]; other site
179408013978	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013979	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408013980	putative active site [active]
179408013981	heme pocket [chemical binding]; other site
179408013982	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013983	putative active site [active]
179408013984	heme pocket [chemical binding]; other site
179408013985	PAS fold; Region: PAS_4; pfam08448
179408013986	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013987	putative active site [active]
179408013988	heme pocket [chemical binding]; other site
179408013989	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013990	PAS domain; Region: PAS_9; pfam13426
179408013991	putative active site [active]
179408013992	heme pocket [chemical binding]; other site
179408013993	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013994	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408013995	putative active site [active]
179408013996	heme pocket [chemical binding]; other site
179408013997	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408013998	putative active site [active]
179408013999	heme pocket [chemical binding]; other site
179408014000	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408014001	PAS fold; Region: PAS_3; pfam08447
179408014002	putative active site [active]
179408014003	heme pocket [chemical binding]; other site
179408014004	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408014005	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408014006	dimer interface [polypeptide binding]; other site
179408014007	phosphorylation site [posttranslational modification]
179408014008	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408014009	ATP binding site [chemical binding]; other site
179408014010	Mg2+ binding site [ion binding]; other site
179408014011	G-X-G motif; other site
179408014012	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408014013	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408014014	active site
179408014015	phosphorylation site [posttranslational modification]
179408014016	intermolecular recognition site; other site
179408014017	dimerization interface [polypeptide binding]; other site
179408014018	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
179408014019	GAF domain; Region: GAF; pfam01590
179408014020	Phytochrome region; Region: PHY; pfam00360
179408014021	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408014022	dimer interface [polypeptide binding]; other site
179408014023	phosphorylation site [posttranslational modification]
179408014024	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408014025	ATP binding site [chemical binding]; other site
179408014026	Mg2+ binding site [ion binding]; other site
179408014027	G-X-G motif; other site
179408014028	Response regulator receiver domain; Region: Response_reg; pfam00072
179408014029	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408014030	active site
179408014031	phosphorylation site [posttranslational modification]
179408014032	intermolecular recognition site; other site
179408014033	dimerization interface [polypeptide binding]; other site
179408014034	Response regulator receiver domain; Region: Response_reg; pfam00072
179408014035	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408014036	active site
179408014037	phosphorylation site [posttranslational modification]
179408014038	intermolecular recognition site; other site
179408014039	dimerization interface [polypeptide binding]; other site
179408014040	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408014041	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408014042	metal binding site [ion binding]; metal-binding site
179408014043	active site
179408014044	I-site; other site
179408014045	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
179408014046	ADP-ribose binding site [chemical binding]; other site
179408014047	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408014048	Probable transposase; Region: OrfB_IS605; pfam01385
179408014049	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408014050	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
179408014051	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
179408014052	dimer interface [polypeptide binding]; other site
179408014053	anticodon binding site; other site
179408014054	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
179408014055	homodimer interface [polypeptide binding]; other site
179408014056	motif 1; other site
179408014057	active site
179408014058	motif 2; other site
179408014059	GAD domain; Region: GAD; pfam02938
179408014060	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
179408014061	motif 3; other site
179408014062	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
179408014063	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
179408014064	putative active site [active]
179408014065	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
179408014066	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
179408014067	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
179408014068	metal binding site [ion binding]; metal-binding site
179408014069	dimer interface [polypeptide binding]; other site
179408014070	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
179408014071	active site
179408014072	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408014073	AAA ATPase domain; Region: AAA_16; pfam13191
179408014074	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408014075	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408014076	Probable transposase; Region: OrfB_IS605; pfam01385
179408014077	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
179408014078	Stage II sporulation protein; Region: SpoIID; pfam08486
179408014079	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
179408014080	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
179408014081	catalytic loop [active]
179408014082	iron binding site [ion binding]; other site
179408014083	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
179408014084	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
179408014085	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
179408014086	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
179408014087	Ligand Binding Site [chemical binding]; other site
179408014088	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
179408014089	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
179408014090	putative Cl- selectivity filter; other site
179408014091	putative pore gating glutamate residue; other site
179408014092	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
179408014093	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
179408014094	putative C-terminal domain interface [polypeptide binding]; other site
179408014095	putative GSH binding site (G-site) [chemical binding]; other site
179408014096	putative dimer interface [polypeptide binding]; other site
179408014097	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
179408014098	N-terminal domain interface [polypeptide binding]; other site
179408014099	dimer interface [polypeptide binding]; other site
179408014100	substrate binding pocket (H-site) [chemical binding]; other site
179408014101	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
179408014102	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
179408014103	Ligand binding site; other site
179408014104	Putative Catalytic site; other site
179408014105	DXD motif; other site
179408014106	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
179408014107	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
179408014108	DDE superfamily endonuclease; Region: DDE_4; cl17710
179408014109	Uncharacterized conserved protein [Function unknown]; Region: COG5607
179408014110	cytochrome c6; Provisional; Region: PRK13697
179408014111	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
179408014112	cytochrome c-550; Provisional; Region: psbV; cl17239
179408014113	cytochrome c-550; Region: PS_II_C550; TIGR03045
179408014114	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
179408014115	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
179408014116	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
179408014117	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
179408014118	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
179408014119	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
179408014120	2TM domain; Region: 2TM; pfam13239
179408014121	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
179408014122	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
179408014123	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
179408014124	PQQ-like domain; Region: PQQ_2; pfam13360
179408014125	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
179408014126	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
179408014127	catalytic residues [active]
179408014128	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
179408014129	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408014130	Walker A/P-loop; other site
179408014131	ATP binding site [chemical binding]; other site
179408014132	Q-loop/lid; other site
179408014133	ABC transporter signature motif; other site
179408014134	Walker B; other site
179408014135	D-loop; other site
179408014136	H-loop/switch region; other site
179408014137	TOBE domain; Region: TOBE_2; pfam08402
179408014138	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
179408014139	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
179408014140	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
179408014141	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408014142	dimer interface [polypeptide binding]; other site
179408014143	conserved gate region; other site
179408014144	ABC-ATPase subunit interface; other site
179408014145	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408014146	dimer interface [polypeptide binding]; other site
179408014147	conserved gate region; other site
179408014148	putative PBP binding loops; other site
179408014149	ABC-ATPase subunit interface; other site
179408014150	Uncharacterized conserved protein [Function unknown]; Region: COG3349
179408014151	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
179408014152	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
179408014153	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
179408014154	Cl- selectivity filter; other site
179408014155	Cl- binding residues [ion binding]; other site
179408014156	pore gating glutamate residue; other site
179408014157	dimer interface [polypeptide binding]; other site
179408014158	H+/Cl- coupling transport residue; other site
179408014159	FOG: CBS domain [General function prediction only]; Region: COG0517
179408014160	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
179408014161	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
179408014162	Ligand Binding Site [chemical binding]; other site
179408014163	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
179408014164	Ligand Binding Site [chemical binding]; other site
179408014165	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835
179408014166	active site
179408014167	catalytic triad [active]
179408014168	oxyanion hole [active]
179408014169	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
179408014170	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
179408014171	HEAT repeats; Region: HEAT_2; pfam13646
179408014172	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
179408014173	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
179408014174	HEAT repeats; Region: HEAT_2; pfam13646
179408014175	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
179408014176	HEAT repeats; Region: HEAT_2; pfam13646
179408014177	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
179408014178	HEAT repeats; Region: HEAT_2; pfam13646
179408014179	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
179408014180	HEAT repeats; Region: HEAT_2; pfam13646
179408014181	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
179408014182	HEAT repeats; Region: HEAT_2; pfam13646
179408014183	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
179408014184	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
179408014185	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
179408014186	protein binding surface [polypeptide binding]; other site
179408014187	HEAT repeats; Region: HEAT_2; pfam13646
179408014188	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
179408014189	protein binding surface [polypeptide binding]; other site
179408014190	HEAT repeats; Region: HEAT_2; pfam13646
179408014191	HEAT repeats; Region: HEAT_2; pfam13646
179408014192	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
179408014193	metal binding triad [ion binding]; metal-binding site
179408014194	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
179408014195	active site
179408014196	hydrophilic channel; other site
179408014197	dimerization interface [polypeptide binding]; other site
179408014198	catalytic residues [active]
179408014199	active site lid [active]
179408014200	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014201	TPR repeat; Region: TPR_11; pfam13414
179408014202	binding surface
179408014203	TPR motif; other site
179408014204	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014205	binding surface
179408014206	TPR motif; other site
179408014207	TPR repeat; Region: TPR_11; pfam13414
179408014208	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014209	binding surface
179408014210	TPR motif; other site
179408014211	TPR repeat; Region: TPR_11; pfam13414
179408014212	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014213	binding surface
179408014214	TPR motif; other site
179408014215	TPR repeat; Region: TPR_11; pfam13414
179408014216	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
179408014217	intersubunit interface [polypeptide binding]; other site
179408014218	active site
179408014219	catalytic residue [active]
179408014220	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
179408014221	Recombination protein O N terminal; Region: RecO_N; pfam11967
179408014222	Recombination protein O C terminal; Region: RecO_C; pfam02565
179408014223	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
179408014224	H+ Antiporter protein; Region: 2A0121; TIGR00900
179408014225	putative substrate translocation pore; other site
179408014226	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
179408014227	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408014228	Uncharacterized conserved protein [Function unknown]; Region: COG2898
179408014229	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
179408014230	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
179408014231	Putative esterase; Region: Esterase; pfam00756
179408014232	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
179408014233	nudix motif; other site
179408014234	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619
179408014235	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
179408014236	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
179408014237	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
179408014238	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
179408014239	Protein of unknown function (DUF4090); Region: DUF4090; pfam13319
179408014240	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179
179408014241	putative active site [active]
179408014242	catalytic site [active]
179408014243	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
179408014244	ATP binding site [chemical binding]; other site
179408014245	putative Mg++ binding site [ion binding]; other site
179408014246	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
179408014247	nucleotide binding region [chemical binding]; other site
179408014248	ATP-binding site [chemical binding]; other site
179408014249	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
179408014250	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
179408014251	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
179408014252	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
179408014253	Protein of unknown function (DUF499); Region: DUF499; pfam04465
179408014254	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
179408014255	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
179408014256	tetramer interface [polypeptide binding]; other site
179408014257	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408014258	catalytic residue [active]
179408014259	ornithine carbamoyltransferase; Provisional; Region: PRK00779
179408014260	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
179408014261	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
179408014262	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
179408014263	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
179408014264	FMN binding site [chemical binding]; other site
179408014265	active site
179408014266	catalytic residues [active]
179408014267	substrate binding site [chemical binding]; other site
179408014268	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
179408014269	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
179408014270	active site
179408014271	dimer interface [polypeptide binding]; other site
179408014272	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
179408014273	dimer interface [polypeptide binding]; other site
179408014274	active site
179408014275	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
179408014276	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408014277	active site
179408014278	phosphorylation site [posttranslational modification]
179408014279	intermolecular recognition site; other site
179408014280	dimerization interface [polypeptide binding]; other site
179408014281	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
179408014282	DNA binding residues [nucleotide binding]
179408014283	dimerization interface [polypeptide binding]; other site
179408014284	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
179408014285	Low molecular weight phosphatase family; Region: LMWPc; cd00115
179408014286	active site
179408014287	hypothetical protein; Validated; Region: PRK00153
179408014288	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
179408014289	FAD binding domain; Region: FAD_binding_4; pfam01565
179408014290	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
179408014291	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
179408014292	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
179408014293	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
179408014294	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
179408014295	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
179408014296	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
179408014297	active site
179408014298	(T/H)XGH motif; other site
179408014299	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403
179408014300	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
179408014301	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
179408014302	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
179408014303	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
179408014304	NADP-binding site; other site
179408014305	homotetramer interface [polypeptide binding]; other site
179408014306	substrate binding site [chemical binding]; other site
179408014307	homodimer interface [polypeptide binding]; other site
179408014308	active site
179408014309	Protein of unknown function, DUF288; Region: DUF288; pfam03385
179408014310	TPR repeat; Region: TPR_11; pfam13414
179408014311	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014312	binding surface
179408014313	TPR motif; other site
179408014314	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014315	binding surface
179408014316	TPR motif; other site
179408014317	TPR repeat; Region: TPR_11; pfam13414
179408014318	TPR repeat; Region: TPR_11; pfam13414
179408014319	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014320	TPR motif; other site
179408014321	binding surface
179408014322	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014323	binding surface
179408014324	TPR motif; other site
179408014325	TPR repeat; Region: TPR_11; pfam13414
179408014326	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014327	binding surface
179408014328	TPR motif; other site
179408014329	Methyltransferase domain; Region: Methyltransf_11; pfam08241
179408014330	Methyltransferase domain; Region: Methyltransf_23; pfam13489
179408014331	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408014332	S-adenosylmethionine binding site [chemical binding]; other site
179408014333	Methyltransferase domain; Region: Methyltransf_23; pfam13489
179408014334	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
179408014335	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
179408014336	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
179408014337	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
179408014338	TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926
179408014339	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
179408014340	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
179408014341	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
179408014342	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014343	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408014344	binding surface
179408014345	TPR motif; other site
179408014346	TPR repeat; Region: TPR_11; pfam13414
179408014347	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014348	binding surface
179408014349	TPR motif; other site
179408014350	TPR repeat; Region: TPR_11; pfam13414
179408014351	TPR repeat; Region: TPR_11; pfam13414
179408014352	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014353	binding surface
179408014354	TPR motif; other site
179408014355	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
179408014356	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
179408014357	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
179408014358	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408014359	active site
179408014360	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
179408014361	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408014362	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
179408014363	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408014364	active site
179408014365	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408014366	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
179408014367	active site
179408014368	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
179408014369	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014370	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
179408014371	binding surface
179408014372	TPR motif; other site
179408014373	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014374	binding surface
179408014375	TPR motif; other site
179408014376	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014377	binding surface
179408014378	TPR motif; other site
179408014379	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014380	binding surface
179408014381	TPR motif; other site
179408014382	TPR repeat; Region: TPR_11; pfam13414
179408014383	TPR repeat; Region: TPR_11; pfam13414
179408014384	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014385	binding surface
179408014386	Tetratricopeptide repeat; Region: TPR_16; pfam13432
179408014387	TPR motif; other site
179408014388	TPR repeat; Region: TPR_11; pfam13414
179408014389	Tetratricopeptide repeats; Region: TPR; smart00028
179408014390	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
179408014391	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014392	binding surface
179408014393	TPR motif; other site
179408014394	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014395	binding surface
179408014396	TPR motif; other site
179408014397	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014398	binding surface
179408014399	TPR motif; other site
179408014400	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014401	binding surface
179408014402	TPR motif; other site
179408014403	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014404	binding surface
179408014405	TPR motif; other site
179408014406	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014407	binding surface
179408014408	TPR motif; other site
179408014409	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014410	binding surface
179408014411	TPR motif; other site
179408014412	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014413	binding surface
179408014414	TPR motif; other site
179408014415	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014416	TPR motif; other site
179408014417	binding surface
179408014418	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014419	TPR motif; other site
179408014420	binding surface
179408014421	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014422	binding surface
179408014423	TPR motif; other site
179408014424	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
179408014425	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
179408014426	Probable Catalytic site; other site
179408014427	metal-binding site
179408014428	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
179408014429	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
179408014430	Probable Catalytic site; other site
179408014431	metal-binding site
179408014432	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
179408014433	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
179408014434	5S rRNA interface [nucleotide binding]; other site
179408014435	CTC domain interface [polypeptide binding]; other site
179408014436	L16 interface [polypeptide binding]; other site
179408014437	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
179408014438	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408014439	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
179408014440	Walker A motif; other site
179408014441	ATP binding site [chemical binding]; other site
179408014442	Walker B motif; other site
179408014443	arginine finger; other site
179408014444	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
179408014445	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
179408014446	GDP-binding site [chemical binding]; other site
179408014447	ACT binding site; other site
179408014448	IMP binding site; other site
179408014449	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
179408014450	Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze  the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443
179408014451	active site
179408014452	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
179408014453	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
179408014454	inhibitor-cofactor binding pocket; inhibition site
179408014455	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408014456	catalytic residue [active]
179408014457	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
179408014458	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
179408014459	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
179408014460	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
179408014461	DNA methylase; Region: N6_N4_Mtase; cl17433
179408014462	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
179408014463	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
179408014464	SnoaL-like domain; Region: SnoaL_3; pfam13474
179408014465	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
179408014466	active site
179408014467	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
179408014468	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
179408014469	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015
179408014470	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
179408014471	Zn2+ binding site [ion binding]; other site
179408014472	Mg2+ binding site [ion binding]; other site
179408014473	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
179408014474	AAA domain; Region: AAA_33; pfam13671
179408014475	active site
179408014476	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
179408014477	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
179408014478	NAD binding site [chemical binding]; other site
179408014479	catalytic Zn binding site [ion binding]; other site
179408014480	structural Zn binding site [ion binding]; other site
179408014481	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
179408014482	MutS domain I; Region: MutS_I; pfam01624
179408014483	MutS domain II; Region: MutS_II; pfam05188
179408014484	MutS domain III; Region: MutS_III; pfam05192
179408014485	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
179408014486	Walker A/P-loop; other site
179408014487	ATP binding site [chemical binding]; other site
179408014488	Q-loop/lid; other site
179408014489	ABC transporter signature motif; other site
179408014490	Walker B; other site
179408014491	D-loop; other site
179408014492	H-loop/switch region; other site
179408014493	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
179408014494	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
179408014495	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
179408014496	active site
179408014497	catalytic residues [active]
179408014498	DNA binding site [nucleotide binding]
179408014499	Int/Topo IB signature motif; other site
179408014500	hypothetical protein; Provisional; Region: PRK07206
179408014501	D5 N terminal like; Region: D5_N; cl07360
179408014502	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
179408014503	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
179408014504	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
179408014505	GIY-YIG motif/motif A; other site
179408014506	active site
179408014507	catalytic site [active]
179408014508	putative DNA binding site [nucleotide binding]; other site
179408014509	metal binding site [ion binding]; metal-binding site
179408014510	UvrB/uvrC motif; Region: UVR; pfam02151
179408014511	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
179408014512	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
179408014513	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
179408014514	Walker A/P-loop; other site
179408014515	ATP binding site [chemical binding]; other site
179408014516	Q-loop/lid; other site
179408014517	ABC transporter signature motif; other site
179408014518	Walker B; other site
179408014519	D-loop; other site
179408014520	H-loop/switch region; other site
179408014521	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
179408014522	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408014523	dimer interface [polypeptide binding]; other site
179408014524	conserved gate region; other site
179408014525	putative PBP binding loops; other site
179408014526	ABC-ATPase subunit interface; other site
179408014527	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
179408014528	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408014529	conserved gate region; other site
179408014530	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408014531	putative PBP binding loops; other site
179408014532	dimer interface [polypeptide binding]; other site
179408014533	ABC-ATPase subunit interface; other site
179408014534	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
179408014535	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
179408014536	substrate binding pocket [chemical binding]; other site
179408014537	membrane-bound complex binding site; other site
179408014538	hinge residues; other site
179408014539	GAF domain; Region: GAF_3; pfam13492
179408014540	PAS fold; Region: PAS_4; pfam08448
179408014541	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408014542	PAS fold; Region: PAS_3; pfam08447
179408014543	putative active site [active]
179408014544	heme pocket [chemical binding]; other site
179408014545	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408014546	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408014547	putative active site [active]
179408014548	heme pocket [chemical binding]; other site
179408014549	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408014550	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408014551	putative active site [active]
179408014552	heme pocket [chemical binding]; other site
179408014553	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408014554	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408014555	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408014556	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408014557	dimer interface [polypeptide binding]; other site
179408014558	phosphorylation site [posttranslational modification]
179408014559	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408014560	ATP binding site [chemical binding]; other site
179408014561	Mg2+ binding site [ion binding]; other site
179408014562	G-X-G motif; other site
179408014563	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408014564	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408014565	active site
179408014566	phosphorylation site [posttranslational modification]
179408014567	intermolecular recognition site; other site
179408014568	dimerization interface [polypeptide binding]; other site
179408014569	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408014570	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408014571	active site
179408014572	phosphorylation site [posttranslational modification]
179408014573	intermolecular recognition site; other site
179408014574	dimerization interface [polypeptide binding]; other site
179408014575	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
179408014576	putative binding surface; other site
179408014577	active site
179408014578	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
179408014579	Fasciclin domain; Region: Fasciclin; pfam02469
179408014580	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK09616
179408014581	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
179408014582	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
179408014583	putative dimer interface [polypeptide binding]; other site
179408014584	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
179408014585	Permease; Region: Permease; cl00510
179408014586	Protein of unknown function (DUF3119); Region: DUF3119; pfam11317
179408014587	Prefoldin subunit; Region: Prefoldin_2; pfam01920
179408014588	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
179408014589	membrane protein; Provisional; Region: PRK14419
179408014590	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408014591	putative active site [active]
179408014592	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
179408014593	pyrroline-5-carboxylate reductase; Region: PLN02688
179408014594	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
179408014595	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
179408014596	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
179408014597	catalytic residue [active]
179408014598	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
179408014599	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
179408014600	Cobalt transport protein; Region: CbiQ; cl00463
179408014601	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
179408014602	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
179408014603	four helix bundle protein; Region: TIGR02436
179408014604	GTP-binding protein Der; Reviewed; Region: PRK00093
179408014605	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
179408014606	G1 box; other site
179408014607	GTP/Mg2+ binding site [chemical binding]; other site
179408014608	Switch I region; other site
179408014609	G2 box; other site
179408014610	Switch II region; other site
179408014611	G3 box; other site
179408014612	G4 box; other site
179408014613	G5 box; other site
179408014614	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
179408014615	G1 box; other site
179408014616	GTP/Mg2+ binding site [chemical binding]; other site
179408014617	Switch I region; other site
179408014618	G2 box; other site
179408014619	G3 box; other site
179408014620	Switch II region; other site
179408014621	G4 box; other site
179408014622	G5 box; other site
179408014623	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
179408014624	Cupin domain; Region: Cupin_2; cl17218
179408014625	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
179408014626	RNA polymerase sigma factor; Provisional; Region: PRK12519
179408014627	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
179408014628	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
179408014629	DNA binding residues [nucleotide binding]
179408014630	Domain of unknown function (DUF4331); Region: DUF4331; pfam14224
179408014631	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014632	binding surface
179408014633	TPR motif; other site
179408014634	High-affinity nickel-transport protein; Region: NicO; cl00964
179408014635	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
179408014636	cobyric acid synthase; Provisional; Region: PRK00784
179408014637	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
179408014638	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
179408014639	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
179408014640	catalytic triad [active]
179408014641	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
179408014642	catalytic loop [active]
179408014643	iron binding site [ion binding]; other site
179408014644	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
179408014645	classical (c) SDRs; Region: SDR_c; cd05233
179408014646	NAD(P) binding site [chemical binding]; other site
179408014647	active site
179408014648	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622
179408014649	Rapsyn N-terminal myristoylation and linker region; Region: Rapsyn_N; pfam10579
179408014650	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014651	binding surface
179408014652	TPR motif; other site
179408014653	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408014654	TPR repeat; Region: TPR_11; pfam13414
179408014655	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014656	binding surface
179408014657	TPR motif; other site
179408014658	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408014659	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408014660	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014661	binding surface
179408014662	TPR motif; other site
179408014663	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408014664	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408014665	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014666	binding surface
179408014667	TPR motif; other site
179408014668	CHAT domain; Region: CHAT; pfam12770
179408014669	photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069
179408014670	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
179408014671	RNA binding surface [nucleotide binding]; other site
179408014672	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
179408014673	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408014674	DNA methylase; Region: N6_N4_Mtase; cl17433
179408014675	Restriction endonuclease XhoI; Region: XhoI; pfam04555
179408014676	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408014677	putative active site [active]
179408014678	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
179408014679	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
179408014680	ligand binding site [chemical binding]; other site
179408014681	NAD binding site [chemical binding]; other site
179408014682	dimerization interface [polypeptide binding]; other site
179408014683	catalytic site [active]
179408014684	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
179408014685	putative L-serine binding site [chemical binding]; other site
179408014686	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
179408014687	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408014688	S-adenosylmethionine binding site [chemical binding]; other site
179408014689	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408014690	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408014691	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408014692	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408014693	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408014694	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408014695	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408014696	DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864
179408014697	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
179408014698	active site
179408014699	substrate binding site [chemical binding]; other site
179408014700	Mg2+ binding site [ion binding]; other site
179408014701	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408014702	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408014703	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408014704	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408014705	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408014706	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
179408014707	metal coordination site [ion binding]; other site
179408014708	Uncharacterized conserved protein [Function unknown]; Region: COG3391
179408014709	DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864
179408014710	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
179408014711	active site
179408014712	substrate binding site [chemical binding]; other site
179408014713	Mg2+ binding site [ion binding]; other site
179408014714	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
179408014715	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
179408014716	catalytic residues [active]
179408014717	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
179408014718	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
179408014719	NAD(P) binding site [chemical binding]; other site
179408014720	homotetramer interface [polypeptide binding]; other site
179408014721	homodimer interface [polypeptide binding]; other site
179408014722	active site
179408014723	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
179408014724	HD domain; Region: HD_4; pfam13328
179408014725	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
179408014726	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
179408014727	nudix motif; other site
179408014728	nudix motif; other site
179408014729	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
179408014730	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
179408014731	catalytic loop [active]
179408014732	iron binding site [ion binding]; other site
179408014733	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
179408014734	cyclase homology domain; Region: CHD; cd07302
179408014735	nucleotidyl binding site; other site
179408014736	metal binding site [ion binding]; metal-binding site
179408014737	dimer interface [polypeptide binding]; other site
179408014738	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408014739	Probable transposase; Region: OrfB_IS605; pfam01385
179408014740	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408014741	Methyltransferase domain; Region: Methyltransf_31; pfam13847
179408014742	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408014743	S-adenosylmethionine binding site [chemical binding]; other site
179408014744	Lipoxygenase; Region: Lipoxygenase; pfam00305
179408014745	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
179408014746	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
179408014747	Fatty acid desaturase; Region: FA_desaturase; pfam00487
179408014748	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
179408014749	putative di-iron ligands [ion binding]; other site
179408014750	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
179408014751	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
179408014752	putative catalytic cysteine [active]
179408014753	Giardia variant-specific surface protein; Region: VSP; pfam03302
179408014754	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
179408014755	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
179408014756	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408014757	Walker A/P-loop; other site
179408014758	ATP binding site [chemical binding]; other site
179408014759	Q-loop/lid; other site
179408014760	ABC transporter signature motif; other site
179408014761	Walker B; other site
179408014762	D-loop; other site
179408014763	H-loop/switch region; other site
179408014764	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
179408014765	metal binding site [ion binding]; metal-binding site
179408014766	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
179408014767	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620
179408014768	FOG: CBS domain [General function prediction only]; Region: COG0517
179408014769	FOG: CBS domain [General function prediction only]; Region: COG0517
179408014770	FOG: CBS domain [General function prediction only]; Region: COG0517
179408014771	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
179408014772	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
179408014773	dimer interface [polypeptide binding]; other site
179408014774	phosphorylation site [posttranslational modification]
179408014775	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408014776	ATP binding site [chemical binding]; other site
179408014777	Mg2+ binding site [ion binding]; other site
179408014778	G-X-G motif; other site
179408014779	photochlorophyllide reductase subunit L; Region: chlL; CHL00072
179408014780	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
179408014781	P-loop; other site
179408014782	Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
179408014783	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
179408014784	YcfA-like protein; Region: YcfA; cl00752
179408014785	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
179408014786	HicB family; Region: HicB; pfam05534
179408014787	TPR repeat; Region: TPR_11; pfam13414
179408014788	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408014789	TPR motif; other site
179408014790	binding surface
179408014791	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
179408014792	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
179408014793	putative active site [active]
179408014794	putative NTP binding site [chemical binding]; other site
179408014795	putative nucleic acid binding site [nucleotide binding]; other site
179408014796	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
179408014797	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
179408014798	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
179408014799	putative active site [active]
179408014800	putative metal binding site [ion binding]; other site
179408014801	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408014802	active site
179408014803	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
179408014804	putative active site [active]
179408014805	putative catalytic site [active]
179408014806	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
179408014807	Predicted membrane protein [Function unknown]; Region: COG3463
179408014808	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
179408014809	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
179408014810	anti sigma factor interaction site; other site
179408014811	regulatory phosphorylation site [posttranslational modification]; other site
179408014812	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
179408014813	Bacterial sugar transferase; Region: Bac_transf; pfam02397
179408014814	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
179408014815	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
179408014816	ATP binding site [chemical binding]; other site
179408014817	Mg2+ binding site [ion binding]; other site
179408014818	G-X-G motif; other site
179408014819	putative glycosyl transferase; Provisional; Region: PRK10307
179408014820	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
179408014821	XisH protein; Region: XisH; pfam08814
179408014822	XisI protein; Region: XisI; pfam08869
179408014823	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
179408014824	Zn2+ binding site [ion binding]; other site
179408014825	Mg2+ binding site [ion binding]; other site
179408014826	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
179408014827	Protein of unknown function (DUF1230); Region: DUF1230; pfam06799
179408014828	L-asparaginase II; Region: Asparaginase_II; cl01842
179408014829	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408014830	Probable transposase; Region: OrfB_IS605; pfam01385
179408014831	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408014832	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
179408014833	Cache domain; Region: Cache_1; pfam02743
179408014834	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408014835	dimerization interface [polypeptide binding]; other site
179408014836	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408014837	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408014838	putative active site [active]
179408014839	heme pocket [chemical binding]; other site
179408014840	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408014841	putative active site [active]
179408014842	heme pocket [chemical binding]; other site
179408014843	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408014844	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408014845	dimer interface [polypeptide binding]; other site
179408014846	phosphorylation site [posttranslational modification]
179408014847	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408014848	ATP binding site [chemical binding]; other site
179408014849	Mg2+ binding site [ion binding]; other site
179408014850	G-X-G motif; other site
179408014851	Rhomboid family; Region: Rhomboid; pfam01694
179408014852	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
179408014853	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
179408014854	non-specific DNA binding site [nucleotide binding]; other site
179408014855	salt bridge; other site
179408014856	sequence-specific DNA binding site [nucleotide binding]; other site
179408014857	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408014858	putative active site [active]
179408014859	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408014860	putative active site [active]
179408014861	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
179408014862	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
179408014863	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
179408014864	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
179408014865	RNA-binding motif; other site
179408014866	DNA-binding site [nucleotide binding]; DNA binding site
179408014867	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
179408014868	DNA-binding site [nucleotide binding]; DNA binding site
179408014869	RNA-binding motif; other site
179408014870	photochlorophyllide reductase subunit B; Region: chlB; CHL00076
179408014871	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
179408014872	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
179408014873	KTSC domain; Region: KTSC; pfam13619
179408014874	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408014875	active site
179408014876	ATP binding site [chemical binding]; other site
179408014877	Protein kinase domain; Region: Pkinase; pfam00069
179408014878	substrate binding site [chemical binding]; other site
179408014879	activation loop (A-loop); other site
179408014880	AAA ATPase domain; Region: AAA_16; pfam13191
179408014881	Predicted ATPase [General function prediction only]; Region: COG3899
179408014882	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408014883	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408014884	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408014885	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408014886	dimer interface [polypeptide binding]; other site
179408014887	phosphorylation site [posttranslational modification]
179408014888	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408014889	ATP binding site [chemical binding]; other site
179408014890	Mg2+ binding site [ion binding]; other site
179408014891	G-X-G motif; other site
179408014892	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
179408014893	propionate/acetate kinase; Provisional; Region: PRK12379
179408014894	photosystem I reaction center subunit X; Reviewed; Region: PRK13214
179408014895	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
179408014896	catalytic core [active]
179408014897	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408014898	AAA domain; Region: AAA_23; pfam13476
179408014899	AAA domain; Region: AAA_21; pfam13304
179408014900	Walker A/P-loop; other site
179408014901	ATP binding site [chemical binding]; other site
179408014902	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408014903	Walker B; other site
179408014904	D-loop; other site
179408014905	H-loop/switch region; other site
179408014906	putative phosphoketolase; Provisional; Region: PRK05261
179408014907	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
179408014908	TPP-binding site; other site
179408014909	XFP C-terminal domain; Region: XFP_C; pfam09363
179408014910	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
179408014911	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
179408014912	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408014913	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408014914	active site
179408014915	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
179408014916	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
179408014917	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
179408014918	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
179408014919	Magnesium ion binding site [ion binding]; other site
179408014920	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408014921	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408014922	active site
179408014923	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
179408014924	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
179408014925	active site
179408014926	interdomain interaction site; other site
179408014927	putative metal-binding site [ion binding]; other site
179408014928	nucleotide binding site [chemical binding]; other site
179408014929	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
179408014930	domain I; other site
179408014931	phosphate binding site [ion binding]; other site
179408014932	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
179408014933	domain II; other site
179408014934	domain III; other site
179408014935	nucleotide binding site [chemical binding]; other site
179408014936	DNA binding groove [nucleotide binding]
179408014937	catalytic site [active]
179408014938	domain IV; other site
179408014939	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
179408014940	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
179408014941	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
179408014942	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
179408014943	Protein kinase domain; Region: Pkinase; pfam00069
179408014944	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408014945	active site
179408014946	ATP binding site [chemical binding]; other site
179408014947	substrate binding site [chemical binding]; other site
179408014948	activation loop (A-loop); other site
179408014949	AAA ATPase domain; Region: AAA_16; pfam13191
179408014950	Predicted ATPase [General function prediction only]; Region: COG3899
179408014951	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408014952	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408014953	PAS domain S-box; Region: sensory_box; TIGR00229
179408014954	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408014955	putative active site [active]
179408014956	heme pocket [chemical binding]; other site
179408014957	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
179408014958	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408014959	putative active site [active]
179408014960	heme pocket [chemical binding]; other site
179408014961	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408014962	dimer interface [polypeptide binding]; other site
179408014963	phosphorylation site [posttranslational modification]
179408014964	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408014965	ATP binding site [chemical binding]; other site
179408014966	Mg2+ binding site [ion binding]; other site
179408014967	G-X-G motif; other site
179408014968	Response regulator receiver domain; Region: Response_reg; pfam00072
179408014969	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408014970	active site
179408014971	phosphorylation site [posttranslational modification]
179408014972	intermolecular recognition site; other site
179408014973	dimerization interface [polypeptide binding]; other site
179408014974	Response regulator receiver domain; Region: Response_reg; pfam00072
179408014975	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408014976	active site
179408014977	phosphorylation site [posttranslational modification]
179408014978	intermolecular recognition site; other site
179408014979	dimerization interface [polypeptide binding]; other site
179408014980	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408014981	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408014982	dimer interface [polypeptide binding]; other site
179408014983	phosphorylation site [posttranslational modification]
179408014984	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408014985	ATP binding site [chemical binding]; other site
179408014986	Mg2+ binding site [ion binding]; other site
179408014987	G-X-G motif; other site
179408014988	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
179408014989	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408014990	dimerization interface [polypeptide binding]; other site
179408014991	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
179408014992	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
179408014993	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
179408014994	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
179408014995	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
179408014996	NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504
179408014997	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
179408014998	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408014999	putative active site [active]
179408015000	cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194
179408015001	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
179408015002	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
179408015003	Walker A/P-loop; other site
179408015004	ATP binding site [chemical binding]; other site
179408015005	Q-loop/lid; other site
179408015006	ABC transporter signature motif; other site
179408015007	Walker B; other site
179408015008	D-loop; other site
179408015009	H-loop/switch region; other site
179408015010	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
179408015011	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408015012	Coenzyme A binding pocket [chemical binding]; other site
179408015013	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
179408015014	ArsC family; Region: ArsC; pfam03960
179408015015	catalytic residue [active]
179408015016	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
179408015017	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
179408015018	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
179408015019	active site
179408015020	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408015021	GAF domain; Region: GAF; pfam01590
179408015022	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408015023	PAS domain; Region: PAS_9; pfam13426
179408015024	putative active site [active]
179408015025	heme pocket [chemical binding]; other site
179408015026	Heme NO binding associated; Region: HNOBA; pfam07701
179408015027	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
179408015028	cyclase homology domain; Region: CHD; cd07302
179408015029	nucleotidyl binding site; other site
179408015030	metal binding site [ion binding]; metal-binding site
179408015031	dimer interface [polypeptide binding]; other site
179408015032	Predicted transcriptional regulators [Transcription]; Region: COG1725
179408015033	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
179408015034	DNA-binding site [nucleotide binding]; DNA binding site
179408015035	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
179408015036	dimer interface [polypeptide binding]; other site
179408015037	FMN binding site [chemical binding]; other site
179408015038	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408015039	Probable transposase; Region: OrfB_IS605; pfam01385
179408015040	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408015041	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
179408015042	PAS fold; Region: PAS_4; pfam08448
179408015043	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408015044	PAS fold; Region: PAS_3; pfam08447
179408015045	putative active site [active]
179408015046	heme pocket [chemical binding]; other site
179408015047	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408015048	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408015049	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408015050	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408015051	metal binding site [ion binding]; metal-binding site
179408015052	active site
179408015053	I-site; other site
179408015054	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
179408015055	Response regulator receiver domain; Region: Response_reg; pfam00072
179408015056	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408015057	active site
179408015058	phosphorylation site [posttranslational modification]
179408015059	intermolecular recognition site; other site
179408015060	dimerization interface [polypeptide binding]; other site
179408015061	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408015062	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408015063	binding surface
179408015064	TPR motif; other site
179408015065	TPR repeat; Region: TPR_11; pfam13414
179408015066	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
179408015067	23S rRNA binding site [nucleotide binding]; other site
179408015068	L21 binding site [polypeptide binding]; other site
179408015069	L13 binding site [polypeptide binding]; other site
179408015070	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
179408015071	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
179408015072	pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149
179408015073	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
179408015074	tetramer interface [polypeptide binding]; other site
179408015075	TPP-binding site [chemical binding]; other site
179408015076	heterodimer interface [polypeptide binding]; other site
179408015077	phosphorylation loop region [posttranslational modification]
179408015078	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
179408015079	HSP70 interaction site [polypeptide binding]; other site
179408015080	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
179408015081	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
179408015082	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408015083	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
179408015084	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
179408015085	RNA binding site [nucleotide binding]; other site
179408015086	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
179408015087	RNA binding site [nucleotide binding]; other site
179408015088	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
179408015089	RNA binding site [nucleotide binding]; other site
179408015090	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
179408015091	Chain length determinant protein; Region: Wzz; cl15801
179408015092	Chain length determinant protein; Region: Wzz; cl15801
179408015093	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
179408015094	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
179408015095	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
179408015096	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
179408015097	SLBB domain; Region: SLBB; pfam10531
179408015098	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
179408015099	O-Antigen ligase; Region: Wzy_C; pfam04932
179408015100	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408015101	dimerization interface [polypeptide binding]; other site
179408015102	PAS fold; Region: PAS; pfam00989
179408015103	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408015104	putative active site [active]
179408015105	heme pocket [chemical binding]; other site
179408015106	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408015107	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408015108	dimer interface [polypeptide binding]; other site
179408015109	phosphorylation site [posttranslational modification]
179408015110	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408015111	ATP binding site [chemical binding]; other site
179408015112	Mg2+ binding site [ion binding]; other site
179408015113	G-X-G motif; other site
179408015114	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
179408015115	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
179408015116	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
179408015117	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
179408015118	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
179408015119	ATP-grasp domain; Region: ATP-grasp; pfam02222
179408015120	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
179408015121	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
179408015122	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
179408015123	M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343
179408015124	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
179408015125	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
179408015126	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
179408015127	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
179408015128	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
179408015129	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
179408015130	anti sigma factor interaction site; other site
179408015131	regulatory phosphorylation site [posttranslational modification]; other site
179408015132	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
179408015133	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
179408015134	UDP-galactopyranose mutase; Region: GLF; pfam03275
179408015135	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
179408015136	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408015137	putative homodimer interface [polypeptide binding]; other site
179408015138	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
179408015139	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
179408015140	active site
179408015141	catalytic tetrad [active]
179408015142	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
179408015143	Fasciclin domain; Region: Fasciclin; pfam02469
179408015144	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
179408015145	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
179408015146	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
179408015147	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
179408015148	putative active site [active]
179408015149	dimerization interface [polypeptide binding]; other site
179408015150	putative tRNAtyr binding site [nucleotide binding]; other site
179408015151	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
179408015152	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
179408015153	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
179408015154	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
179408015155	trehalose synthase; Region: treS_nterm; TIGR02456
179408015156	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
179408015157	active site
179408015158	catalytic site [active]
179408015159	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
179408015160	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408015161	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408015162	active site
179408015163	ATP binding site [chemical binding]; other site
179408015164	substrate binding site [chemical binding]; other site
179408015165	activation loop (A-loop); other site
179408015166	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
179408015167	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
179408015168	putative ligand binding site [chemical binding]; other site
179408015169	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
179408015170	PHP domain; Region: PHP; pfam02811
179408015171	active site
179408015172	CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216
179408015173	NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473
179408015174	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
179408015175	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408015176	putative active site [active]
179408015177	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
179408015178	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
179408015179	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
179408015180	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
179408015181	Hexamer interface [polypeptide binding]; other site
179408015182	Hexagonal pore residue; other site
179408015183	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
179408015184	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
179408015185	Hexamer interface [polypeptide binding]; other site
179408015186	Hexagonal pore residue; other site
179408015187	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
179408015188	Hexamer/Pentamer interface [polypeptide binding]; other site
179408015189	central pore; other site
179408015190	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
179408015191	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
179408015192	trimer interface [polypeptide binding]; other site
179408015193	active site
179408015194	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
179408015195	putative multimerization interface [polypeptide binding]; other site
179408015196	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
179408015197	putative multimerization interface [polypeptide binding]; other site
179408015198	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
179408015199	putative multimerization interface [polypeptide binding]; other site
179408015200	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
179408015201	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
179408015202	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
179408015203	Hexamer interface [polypeptide binding]; other site
179408015204	Hexagonal pore residue; other site
179408015205	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
179408015206	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
179408015207	Hexamer interface [polypeptide binding]; other site
179408015208	Hexagonal pore residue; other site
179408015209	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408015210	binding surface
179408015211	TPR repeat; Region: TPR_11; pfam13414
179408015212	TPR motif; other site
179408015213	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408015214	binding surface
179408015215	TPR repeat; Region: TPR_11; pfam13414
179408015216	TPR motif; other site
179408015217	TPR repeat; Region: TPR_11; pfam13414
179408015218	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408015219	binding surface
179408015220	TPR motif; other site
179408015221	TPR repeat; Region: TPR_11; pfam13414
179408015222	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
179408015223	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
179408015224	active site
179408015225	catalytic tetrad [active]
179408015226	Condensation domain; Region: Condensation; pfam00668
179408015227	L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443
179408015228	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
179408015229	acyl-activating enzyme (AAE) consensus motif; other site
179408015230	AMP binding site [chemical binding]; other site
179408015231	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
179408015232	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
179408015233	putative NAD(P) binding site [chemical binding]; other site
179408015234	active site
179408015235	putative substrate binding site [chemical binding]; other site
179408015236	Condensation domain; Region: Condensation; pfam00668
179408015237	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
179408015238	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
179408015239	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
179408015240	acyl-activating enzyme (AAE) consensus motif; other site
179408015241	AMP binding site [chemical binding]; other site
179408015242	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
179408015243	Condensation domain; Region: Condensation; pfam00668
179408015244	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
179408015245	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
179408015246	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
179408015247	Condensation domain; Region: Condensation; pfam00668
179408015248	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
179408015249	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
179408015250	acyl-activating enzyme (AAE) consensus motif; other site
179408015251	AMP binding site [chemical binding]; other site
179408015252	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
179408015253	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
179408015254	Condensation domain; Region: Condensation; pfam00668
179408015255	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
179408015256	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
179408015257	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
179408015258	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
179408015259	catalytic residue [active]
179408015260	Condensation domain; Region: Condensation; pfam00668
179408015261	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
179408015262	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
179408015263	acyl-activating enzyme (AAE) consensus motif; other site
179408015264	AMP binding site [chemical binding]; other site
179408015265	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
179408015266	Condensation domain; Region: Condensation; pfam00668
179408015267	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
179408015268	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
179408015269	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
179408015270	acyl-activating enzyme (AAE) consensus motif; other site
179408015271	AMP binding site [chemical binding]; other site
179408015272	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
179408015273	Condensation domain; Region: Condensation; pfam00668
179408015274	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
179408015275	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
179408015276	acyl-CoA synthetase; Validated; Region: PRK05850
179408015277	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
179408015278	acyl-activating enzyme (AAE) consensus motif; other site
179408015279	active site
179408015280	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
179408015281	Condensation domain; Region: Condensation; pfam00668
179408015282	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
179408015283	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
179408015284	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
179408015285	acyl-activating enzyme (AAE) consensus motif; other site
179408015286	AMP binding site [chemical binding]; other site
179408015287	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
179408015288	Condensation domain; Region: Condensation; pfam00668
179408015289	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
179408015290	Nonribosomal peptide synthase; Region: NRPS; pfam08415
179408015291	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
179408015292	acyl-activating enzyme (AAE) consensus motif; other site
179408015293	AMP binding site [chemical binding]; other site
179408015294	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
179408015295	AMIN domain; Region: AMIN; pfam11741
179408015296	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
179408015297	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
179408015298	N-terminal plug; other site
179408015299	ligand-binding site [chemical binding]; other site
179408015300	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
179408015301	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
179408015302	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
179408015303	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
179408015304	H+ Antiporter protein; Region: 2A0121; TIGR00900
179408015305	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
179408015306	putative substrate translocation pore; other site
179408015307	Penicillin amidase; Region: Penicil_amidase; pfam01804
179408015308	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
179408015309	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
179408015310	active site
179408015311	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
179408015312	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
179408015313	Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; Region: MORN; smart00698
179408015314	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
179408015315	MORN repeat; Region: MORN; cl14787
179408015316	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
179408015317	Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; Region: MORN; smart00698
179408015318	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
179408015319	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
179408015320	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
179408015321	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
179408015322	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
179408015323	glutamate-1-semialdehyde 2,1-aminomutase; Region: PLN02482
179408015324	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
179408015325	inhibitor-cofactor binding pocket; inhibition site
179408015326	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408015327	catalytic residue [active]
179408015328	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
179408015329	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
179408015330	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
179408015331	metal binding site [ion binding]; metal-binding site
179408015332	S-layer homology domain; Region: SLH; pfam00395
179408015333	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
179408015334	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
179408015335	Major Facilitator Superfamily; Region: MFS_1; pfam07690
179408015336	putative substrate translocation pore; other site
179408015337	Predicted membrane protein [Function unknown]; Region: COG2119
179408015338	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
179408015339	Predicted membrane protein [Function unknown]; Region: COG2119
179408015340	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
179408015341	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
179408015342	active site
179408015343	carotene isomerase; Region: carot_isom; TIGR02730
179408015344	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
179408015345	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408015346	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408015347	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408015348	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
179408015349	FOG: CBS domain [General function prediction only]; Region: COG0517
179408015350	FOG: CBS domain [General function prediction only]; Region: COG0517
179408015351	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
179408015352	PAS domain; Region: PAS_9; pfam13426
179408015353	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408015354	putative active site [active]
179408015355	heme pocket [chemical binding]; other site
179408015356	PAS fold; Region: PAS; pfam00989
179408015357	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408015358	putative active site [active]
179408015359	heme pocket [chemical binding]; other site
179408015360	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408015361	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408015362	metal binding site [ion binding]; metal-binding site
179408015363	active site
179408015364	I-site; other site
179408015365	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
179408015366	Protein of unknown function (DUF3148); Region: DUF3148; pfam11347
179408015367	GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541
179408015368	active site
179408015369	GIY-YIG motif/motif A; other site
179408015370	catalytic site [active]
179408015371	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
179408015372	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
179408015373	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
179408015374	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
179408015375	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
179408015376	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
179408015377	Walker A/P-loop; other site
179408015378	ATP binding site [chemical binding]; other site
179408015379	Q-loop/lid; other site
179408015380	ABC transporter signature motif; other site
179408015381	Walker B; other site
179408015382	D-loop; other site
179408015383	H-loop/switch region; other site
179408015384	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408015385	Probable transposase; Region: OrfB_IS605; pfam01385
179408015386	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408015387	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408015388	putative active site [active]
179408015389	Cache domain; Region: Cache_1; pfam02743
179408015390	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408015391	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408015392	dimerization interface [polypeptide binding]; other site
179408015393	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408015394	dimer interface [polypeptide binding]; other site
179408015395	phosphorylation site [posttranslational modification]
179408015396	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408015397	ATP binding site [chemical binding]; other site
179408015398	Mg2+ binding site [ion binding]; other site
179408015399	G-X-G motif; other site
179408015400	Response regulator receiver domain; Region: Response_reg; pfam00072
179408015401	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408015402	active site
179408015403	phosphorylation site [posttranslational modification]
179408015404	intermolecular recognition site; other site
179408015405	dimerization interface [polypeptide binding]; other site
179408015406	Response regulator receiver domain; Region: Response_reg; pfam00072
179408015407	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408015408	active site
179408015409	phosphorylation site [posttranslational modification]
179408015410	intermolecular recognition site; other site
179408015411	dimerization interface [polypeptide binding]; other site
179408015412	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408015413	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408015414	dimer interface [polypeptide binding]; other site
179408015415	phosphorylation site [posttranslational modification]
179408015416	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408015417	ATP binding site [chemical binding]; other site
179408015418	Mg2+ binding site [ion binding]; other site
179408015419	G-X-G motif; other site
179408015420	Thymidylate synthase complementing protein; Region: Thy1; cl03630
179408015421	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
179408015422	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408015423	active site
179408015424	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
179408015425	Thymidylate synthase complementing protein; Region: Thy1; cl03630
179408015426	protein-splicing catalytic site; other site
179408015427	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
179408015428	trimer interface [polypeptide binding]; other site
179408015429	active site
179408015430	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
179408015431	catalytic motif [active]
179408015432	Zn binding site [ion binding]; other site
179408015433	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408015434	non-specific DNA binding site [nucleotide binding]; other site
179408015435	salt bridge; other site
179408015436	sequence-specific DNA binding site [nucleotide binding]; other site
179408015437	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
179408015438	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
179408015439	active site
179408015440	Zn binding site [ion binding]; other site
179408015441	VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457
179408015442	metal ion-dependent adhesion site (MIDAS); other site
179408015443	NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909
179408015444	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
179408015445	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
179408015446	ribosomal protein L23; Region: rpl23; CHL00030
179408015447	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
179408015448	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
179408015449	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
179408015450	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
179408015451	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
179408015452	putative translocon binding site; other site
179408015453	protein-rRNA interface [nucleotide binding]; other site
179408015454	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
179408015455	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
179408015456	G-X-X-G motif; other site
179408015457	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
179408015458	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
179408015459	23S rRNA interface [nucleotide binding]; other site
179408015460	5S rRNA interface [nucleotide binding]; other site
179408015461	putative antibiotic binding site [chemical binding]; other site
179408015462	L25 interface [polypeptide binding]; other site
179408015463	L27 interface [polypeptide binding]; other site
179408015464	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
179408015465	23S rRNA interface [nucleotide binding]; other site
179408015466	putative translocon interaction site; other site
179408015467	signal recognition particle (SRP54) interaction site; other site
179408015468	L23 interface [polypeptide binding]; other site
179408015469	trigger factor interaction site; other site
179408015470	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
179408015471	ribosomal protein L14; Region: rpl14; CHL00057
179408015472	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
179408015473	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
179408015474	RNA binding site [nucleotide binding]; other site
179408015475	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
179408015476	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
179408015477	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
179408015478	ribosomal protein S8; Region: rps8; CHL00042
179408015479	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
179408015480	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
179408015481	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
179408015482	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
179408015483	23S rRNA interface [nucleotide binding]; other site
179408015484	5S rRNA interface [nucleotide binding]; other site
179408015485	L27 interface [polypeptide binding]; other site
179408015486	L5 interface [polypeptide binding]; other site
179408015487	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
179408015488	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
179408015489	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
179408015490	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
179408015491	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
179408015492	SecY translocase; Region: SecY; pfam00344
179408015493	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
179408015494	adenylate kinase; Provisional; Region: adk; PRK02496
179408015495	AMP-binding site [chemical binding]; other site
179408015496	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
179408015497	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
179408015498	rRNA binding site [nucleotide binding]; other site
179408015499	predicted 30S ribosome binding site; other site
179408015500	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
179408015501	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
179408015502	30S ribosomal protein S13; Region: bact_S13; TIGR03631
179408015503	30S ribosomal protein S11; Validated; Region: PRK05309
179408015504	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
179408015505	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
179408015506	alphaNTD - beta interaction site [polypeptide binding]; other site
179408015507	alphaNTD homodimer interface [polypeptide binding]; other site
179408015508	alphaNTD - beta' interaction site [polypeptide binding]; other site
179408015509	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
179408015510	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
179408015511	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
179408015512	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
179408015513	dimerization interface 3.5A [polypeptide binding]; other site
179408015514	active site
179408015515	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
179408015516	23S rRNA interface [nucleotide binding]; other site
179408015517	L3 interface [polypeptide binding]; other site
179408015518	ribosomal protein S9; Region: rps9; CHL00079
179408015519	ribosomal protein L31; Validated; Region: rpl31; CHL00136
179408015520	peptide chain release factor 1; Validated; Region: prfA; PRK00591
179408015521	This domain is found in peptide chain release factors; Region: PCRF; smart00937
179408015522	RF-1 domain; Region: RF-1; pfam00472
179408015523	YcfA-like protein; Region: YcfA; cl00752
179408015524	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408015525	non-specific DNA binding site [nucleotide binding]; other site
179408015526	salt bridge; other site
179408015527	sequence-specific DNA binding site [nucleotide binding]; other site
179408015528	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
179408015529	non-specific DNA interactions [nucleotide binding]; other site
179408015530	DNA binding site [nucleotide binding]
179408015531	sequence specific DNA binding site [nucleotide binding]; other site
179408015532	putative cAMP binding site [chemical binding]; other site
179408015533	Winged helix-turn helix; Region: HTH_29; pfam13551
179408015534	Homeodomain-like domain; Region: HTH_32; pfam13565
179408015535	Winged helix-turn helix; Region: HTH_33; pfam13592
179408015536	DDE superfamily endonuclease; Region: DDE_3; pfam13358
179408015537	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
179408015538	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
179408015539	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
179408015540	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
179408015541	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
179408015542	homodecamer interface [polypeptide binding]; other site
179408015543	GTP cyclohydrolase I; Provisional; Region: PLN03044
179408015544	active site
179408015545	putative catalytic site residues [active]
179408015546	zinc binding site [ion binding]; other site
179408015547	GTP-CH-I/GFRP interaction surface; other site
179408015548	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
179408015549	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
179408015550	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
179408015551	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
179408015552	ABC transporter; Region: ABC_tran_2; pfam12848
179408015553	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
179408015554	Phosphotransferase enzyme family; Region: APH; pfam01636
179408015555	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
179408015556	active site
179408015557	ATP binding site [chemical binding]; other site
179408015558	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
179408015559	substrate binding site [chemical binding]; other site
179408015560	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
179408015561	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
179408015562	CHASE domain; Region: CHASE; cl01369
179408015563	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408015564	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408015565	dimer interface [polypeptide binding]; other site
179408015566	phosphorylation site [posttranslational modification]
179408015567	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408015568	ATP binding site [chemical binding]; other site
179408015569	Mg2+ binding site [ion binding]; other site
179408015570	G-X-G motif; other site
179408015571	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
179408015572	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
179408015573	active site
179408015574	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
179408015575	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
179408015576	dimer interface [polypeptide binding]; other site
179408015577	active site
179408015578	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
179408015579	ABC1 family; Region: ABC1; cl17513
179408015580	GAF domain; Region: GAF; pfam01590
179408015581	GAF domain; Region: GAF; pfam01590
179408015582	GAF domain; Region: GAF_2; pfam13185
179408015583	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408015584	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408015585	dimer interface [polypeptide binding]; other site
179408015586	phosphorylation site [posttranslational modification]
179408015587	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408015588	ATP binding site [chemical binding]; other site
179408015589	Mg2+ binding site [ion binding]; other site
179408015590	G-X-G motif; other site
179408015591	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
179408015592	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
179408015593	substrate binding site [chemical binding]; other site
179408015594	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
179408015595	nudix motif; other site
179408015596	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186
179408015597	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
179408015598	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
179408015599	homodimer interface [polypeptide binding]; other site
179408015600	NADP binding site [chemical binding]; other site
179408015601	substrate binding site [chemical binding]; other site
179408015602	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408015603	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408015604	Methyltransferase domain; Region: Methyltransf_31; pfam13847
179408015605	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408015606	S-adenosylmethionine binding site [chemical binding]; other site
179408015607	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
179408015608	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408015609	Coenzyme A binding pocket [chemical binding]; other site
179408015610	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
179408015611	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
179408015612	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
179408015613	dimerization interface [polypeptide binding]; other site
179408015614	substrate binding pocket [chemical binding]; other site
179408015615	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
179408015616	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
179408015617	substrate binding pocket [chemical binding]; other site
179408015618	chain length determination region; other site
179408015619	substrate-Mg2+ binding site; other site
179408015620	catalytic residues [active]
179408015621	aspartate-rich region 1; other site
179408015622	active site lid residues [active]
179408015623	aspartate-rich region 2; other site
179408015624	Divergent PAP2 family; Region: DUF212; pfam02681
179408015625	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
179408015626	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
179408015627	dinuclear metal binding motif [ion binding]; other site
179408015628	glutamine synthetase, type I; Region: GlnA; TIGR00653
179408015629	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
179408015630	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
179408015631	allophycocyanin beta 18 subunit; Region: apcF; CHL00089
179408015632	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
179408015633	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
179408015634	RNA binding surface [nucleotide binding]; other site
179408015635	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
179408015636	Dynamin family; Region: Dynamin_N; pfam00350
179408015637	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
179408015638	G1 box; other site
179408015639	GTP/Mg2+ binding site [chemical binding]; other site
179408015640	Switch I region; other site
179408015641	G2 box; other site
179408015642	Switch II region; other site
179408015643	G3 box; other site
179408015644	G4 box; other site
179408015645	Domain of unknown function (DUF697); Region: DUF697; pfam05128
179408015646	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408015647	putative active site [active]
179408015648	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
179408015649	Switch II region; other site
179408015650	G4 box; other site
179408015651	G5 box; other site
179408015652	Domain of unknown function (DUF697); Region: DUF697; pfam05128
179408015653	6-phosphofructokinase; Provisional; Region: PRK14071
179408015654	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
179408015655	active site
179408015656	ADP/pyrophosphate binding site [chemical binding]; other site
179408015657	dimerization interface [polypeptide binding]; other site
179408015658	allosteric effector site; other site
179408015659	fructose-1,6-bisphosphate binding site; other site
179408015660	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
179408015661	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
179408015662	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
179408015663	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
179408015664	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
179408015665	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
179408015666	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
179408015667	homodimer interface [polypeptide binding]; other site
179408015668	metal binding site [ion binding]; metal-binding site
179408015669	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
179408015670	homodimer interface [polypeptide binding]; other site
179408015671	active site
179408015672	putative chemical substrate binding site [chemical binding]; other site
179408015673	metal binding site [ion binding]; metal-binding site
179408015674	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
179408015675	Phycobilisome protein; Region: Phycobilisome; cl08227
179408015676	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
179408015677	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
179408015678	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408015679	S-adenosylmethionine binding site [chemical binding]; other site
179408015680	XisH protein; Region: XisH; pfam08814
179408015681	XisI protein; Region: XisI; pfam08869
179408015682	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
179408015683	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
179408015684	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
179408015685	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
179408015686	G1 box; other site
179408015687	GTP/Mg2+ binding site [chemical binding]; other site
179408015688	G2 box; other site
179408015689	Switch I region; other site
179408015690	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
179408015691	G3 box; other site
179408015692	Switch II region; other site
179408015693	GTP/Mg2+ binding site [chemical binding]; other site
179408015694	G4 box; other site
179408015695	G5 box; other site
179408015696	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
179408015697	Dynamin family; Region: Dynamin_N; pfam00350
179408015698	G1 box; other site
179408015699	GTP/Mg2+ binding site [chemical binding]; other site
179408015700	G2 box; other site
179408015701	Switch I region; other site
179408015702	G3 box; other site
179408015703	Switch II region; other site
179408015704	G4 box; other site
179408015705	G5 box; other site
179408015706	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
179408015707	Protein of unknown function (DUF433); Region: DUF433; pfam04255
179408015708	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
179408015709	SPFH domain / Band 7 family; Region: Band_7; pfam01145
179408015710	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
179408015711	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
179408015712	phosphopeptide binding site; other site
179408015713	Uncharacterized conserved protein [Function unknown]; Region: COG3339
179408015714	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
179408015715	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
179408015716	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
179408015717	trimer interface [polypeptide binding]; other site
179408015718	active site
179408015719	UDP-GlcNAc binding site [chemical binding]; other site
179408015720	lipid binding site [chemical binding]; lipid-binding site
179408015721	AAA ATPase domain; Region: AAA_16; pfam13191
179408015722	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408015723	TPR repeat; Region: TPR_11; pfam13414
179408015724	binding surface
179408015725	TPR motif; other site
179408015726	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408015727	binding surface
179408015728	TPR motif; other site
179408015729	TPR repeat; Region: TPR_11; pfam13414
179408015730	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408015731	binding surface
179408015732	TPR motif; other site
179408015733	Uncharacterized conserved protein [Function unknown]; Region: COG4715
179408015734	SWIM zinc finger; Region: SWIM; pfam04434
179408015735	Uncharacterized protein conserved in archaea (DUF2286); Region: DUF2286; cl02234
179408015736	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408015737	TPR motif; other site
179408015738	binding surface
179408015739	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
179408015740	TPR motif; other site
179408015741	binding surface
179408015742	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408015743	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408015744	binding surface
179408015745	TPR motif; other site
179408015746	CHAT domain; Region: CHAT; pfam12770
179408015747	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
179408015748	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
179408015749	active site
179408015750	putative homodimer interface [polypeptide binding]; other site
179408015751	SAM binding site [chemical binding]; other site
179408015752	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
179408015753	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
179408015754	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
179408015755	DNA polymerase III subunit delta; Validated; Region: PRK07452
179408015756	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
179408015757	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
179408015758	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
179408015759	DNA binding residues [nucleotide binding]
179408015760	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
179408015761	catalytic residues [active]
179408015762	catalytic nucleophile [active]
179408015763	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408015764	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408015765	Probable transposase; Region: OrfB_IS605; pfam01385
179408015766	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408015767	S-layer homology domain; Region: SLH; pfam00395
179408015768	BON domain; Region: BON; pfam04972
179408015769	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408015770	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408015771	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408015772	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408015773	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408015774	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408015775	GAF domain; Region: GAF_3; pfam13492
179408015776	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408015777	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408015778	dimer interface [polypeptide binding]; other site
179408015779	phosphorylation site [posttranslational modification]
179408015780	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408015781	ATP binding site [chemical binding]; other site
179408015782	Mg2+ binding site [ion binding]; other site
179408015783	G-X-G motif; other site
179408015784	Response regulator receiver domain; Region: Response_reg; pfam00072
179408015785	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408015786	active site
179408015787	phosphorylation site [posttranslational modification]
179408015788	intermolecular recognition site; other site
179408015789	dimerization interface [polypeptide binding]; other site
179408015790	PAS domain S-box; Region: sensory_box; TIGR00229
179408015791	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408015792	putative active site [active]
179408015793	heme pocket [chemical binding]; other site
179408015794	PAS domain; Region: PAS_9; pfam13426
179408015795	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408015796	putative active site [active]
179408015797	heme pocket [chemical binding]; other site
179408015798	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408015799	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
179408015800	putative active site [active]
179408015801	heme pocket [chemical binding]; other site
179408015802	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408015803	dimer interface [polypeptide binding]; other site
179408015804	phosphorylation site [posttranslational modification]
179408015805	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408015806	ATP binding site [chemical binding]; other site
179408015807	Mg2+ binding site [ion binding]; other site
179408015808	G-X-G motif; other site
179408015809	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408015810	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408015811	active site
179408015812	phosphorylation site [posttranslational modification]
179408015813	intermolecular recognition site; other site
179408015814	dimerization interface [polypeptide binding]; other site
179408015815	S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330
179408015816	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
179408015817	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
179408015818	Transposase IS200 like; Region: Y1_Tnp; pfam01797
179408015819	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408015820	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408015821	Probable transposase; Region: OrfB_IS605; pfam01385
179408015822	c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177
179408015823	ResB-like family; Region: ResB; pfam05140
179408015824	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
179408015825	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
179408015826	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408015827	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408015828	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408015829	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408015830	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408015831	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408015832	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408015833	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408015834	binding surface
179408015835	TPR repeat; Region: TPR_11; pfam13414
179408015836	TPR motif; other site
179408015837	TPR repeat; Region: TPR_11; pfam13414
179408015838	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408015839	binding surface
179408015840	TPR motif; other site
179408015841	TPR repeat; Region: TPR_11; pfam13414
179408015842	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
179408015843	active site
179408015844	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
179408015845	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
179408015846	catalytic triad [active]
179408015847	Predicted membrane protein [Function unknown]; Region: COG3431
179408015848	superoxide dismutase; Provisional; Region: PRK10543
179408015849	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
179408015850	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
179408015851	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
179408015852	CoA binding domain; Region: CoA_binding_2; pfam13380
179408015853	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
179408015854	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
179408015855	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
179408015856	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
179408015857	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
179408015858	Pyruvate formate lyase 1; Region: PFL1; cd01678
179408015859	coenzyme A binding site [chemical binding]; other site
179408015860	active site
179408015861	catalytic residues [active]
179408015862	glycine loop; other site
179408015863	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
179408015864	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408015865	FeS/SAM binding site; other site
179408015866	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
179408015867	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
179408015868	putative catalytic cysteine [active]
179408015869	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
179408015870	putative active site [active]
179408015871	metal binding site [ion binding]; metal-binding site
179408015872	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
179408015873	ATP-grasp ribosomal peptide maturase, MvdD family; Region: ATPgraspMvdD; TIGR04184
179408015874	ATP-grasp domain; Region: ATP-grasp_4; cl17255
179408015875	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
179408015876	Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249
179408015877	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
179408015878	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766
179408015879	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
179408015880	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
179408015881	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
179408015882	trimer interface [polypeptide binding]; other site
179408015883	active site
179408015884	substrate binding site [chemical binding]; other site
179408015885	CoA binding site [chemical binding]; other site
179408015886	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408015887	Probable transposase; Region: OrfB_IS605; pfam01385
179408015888	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408015889	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
179408015890	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
179408015891	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
179408015892	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
179408015893	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408015894	putative active site [active]
179408015895	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408015896	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408015897	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
179408015898	Thiamine monophosphate kinase [Coenzyme metabolism]; Region: ThiL; COG0611
179408015899	dimerization interface [polypeptide binding]; other site
179408015900	ATP binding site [chemical binding]; other site
179408015901	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
179408015902	dimerization interface [polypeptide binding]; other site
179408015903	ATP binding site [chemical binding]; other site
179408015904	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
179408015905	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408015906	active site
179408015907	ATP binding site [chemical binding]; other site
179408015908	substrate binding site [chemical binding]; other site
179408015909	activation loop (A-loop); other site
179408015910	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
179408015911	Uncharacterized conserved protein [Function unknown]; Region: COG1262
179408015912	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
179408015913	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408015914	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408015915	active site
179408015916	ATP binding site [chemical binding]; other site
179408015917	substrate binding site [chemical binding]; other site
179408015918	activation loop (A-loop); other site
179408015919	Uncharacterized conserved protein [Function unknown]; Region: COG1262
179408015920	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
179408015921	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
179408015922	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408015923	amidophosphoribosyltransferase; Provisional; Region: PRK07349
179408015924	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
179408015925	active site
179408015926	tetramer interface [polypeptide binding]; other site
179408015927	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
179408015928	active site
179408015929	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
179408015930	Domain of unknown function (DUF3474); Region: DUF3474; pfam11960
179408015931	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
179408015932	putative di-iron ligands [ion binding]; other site
179408015933	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
179408015934	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
179408015935	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408015936	FeS/SAM binding site; other site
179408015937	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
179408015938	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
179408015939	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
179408015940	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
179408015941	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
179408015942	ligand binding site [chemical binding]; other site
179408015943	flexible hinge region; other site
179408015944	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
179408015945	putative switch regulator; other site
179408015946	non-specific DNA interactions [nucleotide binding]; other site
179408015947	DNA binding site [nucleotide binding]
179408015948	sequence specific DNA binding site [nucleotide binding]; other site
179408015949	putative cAMP binding site [chemical binding]; other site
179408015950	enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370
179408015951	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
179408015952	NAD binding site [chemical binding]; other site
179408015953	homotetramer interface [polypeptide binding]; other site
179408015954	homodimer interface [polypeptide binding]; other site
179408015955	substrate binding site [chemical binding]; other site
179408015956	active site
179408015957	imidazoleglycerol-phosphate dehydratase; Region: PLN02800
179408015958	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
179408015959	putative active site pocket [active]
179408015960	4-fold oligomerization interface [polypeptide binding]; other site
179408015961	metal binding residues [ion binding]; metal-binding site
179408015962	3-fold/trimer interface [polypeptide binding]; other site
179408015963	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
179408015964	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
179408015965	cofactor binding site; other site
179408015966	DNA binding site [nucleotide binding]
179408015967	substrate interaction site [chemical binding]; other site
179408015968	MjaII restriction endonuclease; Region: RE_MjaII; pfam09520
179408015969	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
179408015970	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
179408015971	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
179408015972	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
179408015973	GxxExxY protein; Region: GxxExxY; TIGR04256
179408015974	Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498
179408015975	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
179408015976	active site
179408015977	catalytic triad [active]
179408015978	S-layer homology domain; Region: SLH; pfam00395
179408015979	S-layer homology domain; Region: SLH; pfam00395
179408015980	BolA-like protein; Region: BolA; pfam01722
179408015981	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
179408015982	putative GSH binding site [chemical binding]; other site
179408015983	catalytic residues [active]
179408015984	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
179408015985	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
179408015986	DNA binding residues [nucleotide binding]
179408015987	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
179408015988	catalytic residues [active]
179408015989	catalytic nucleophile [active]
179408015990	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
179408015991	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408015992	active site
179408015993	phosphorylation site [posttranslational modification]
179408015994	intermolecular recognition site; other site
179408015995	dimerization interface [polypeptide binding]; other site
179408015996	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
179408015997	DNA binding site [nucleotide binding]
179408015998	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
179408015999	aromatic arch; other site
179408016000	DCoH dimer interaction site [polypeptide binding]; other site
179408016001	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
179408016002	DCoH tetramer interaction site [polypeptide binding]; other site
179408016003	substrate binding site [chemical binding]; other site
179408016004	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
179408016005	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
179408016006	NAD(P) binding site [chemical binding]; other site
179408016007	catalytic residues [active]
179408016008	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
179408016009	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
179408016010	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
179408016011	Zn2+ binding site [ion binding]; other site
179408016012	Mg2+ binding site [ion binding]; other site
179408016013	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
179408016014	synthetase active site [active]
179408016015	NTP binding site [chemical binding]; other site
179408016016	metal binding site [ion binding]; metal-binding site
179408016017	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
179408016018	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
179408016019	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
179408016020	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
179408016021	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
179408016022	Walker A/P-loop; other site
179408016023	ATP binding site [chemical binding]; other site
179408016024	Q-loop/lid; other site
179408016025	ABC transporter signature motif; other site
179408016026	Walker B; other site
179408016027	D-loop; other site
179408016028	H-loop/switch region; other site
179408016029	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
179408016030	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
179408016031	Walker A/P-loop; other site
179408016032	ATP binding site [chemical binding]; other site
179408016033	Q-loop/lid; other site
179408016034	ABC transporter signature motif; other site
179408016035	Walker B; other site
179408016036	D-loop; other site
179408016037	H-loop/switch region; other site
179408016038	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
179408016039	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
179408016040	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
179408016041	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
179408016042	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
179408016043	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
179408016044	DNA binding residues [nucleotide binding]
179408016045	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
179408016046	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408016047	Coenzyme A binding pocket [chemical binding]; other site
179408016048	Predicted permeases [General function prediction only]; Region: COG0679
179408016049	Protein of unknown function (DUF433); Region: DUF433; cl01030
179408016050	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
179408016051	YcfA-like protein; Region: YcfA; cl00752
179408016052	AAA ATPase domain; Region: AAA_16; pfam13191
179408016053	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408016054	putative active site [active]
179408016055	Putative restriction endonuclease; Region: Uma2; pfam05685
179408016056	Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
179408016057	SnoaL-like domain; Region: SnoaL_2; pfam12680
179408016058	Biofilm formation and stress response factor; Region: BsmA; cl01794
179408016059	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
179408016060	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
179408016061	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
179408016062	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408016063	dimerization interface [polypeptide binding]; other site
179408016064	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408016065	dimerization interface [polypeptide binding]; other site
179408016066	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
179408016067	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408016068	dimerization interface [polypeptide binding]; other site
179408016069	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408016070	dimerization interface [polypeptide binding]; other site
179408016071	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408016072	dimerization interface [polypeptide binding]; other site
179408016073	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
179408016074	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408016075	dimerization interface [polypeptide binding]; other site
179408016076	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408016077	dimerization interface [polypeptide binding]; other site
179408016078	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408016079	dimerization interface [polypeptide binding]; other site
179408016080	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408016081	dimerization interface [polypeptide binding]; other site
179408016082	GAF domain; Region: GAF_2; pfam13185
179408016083	GAF domain; Region: GAF; pfam01590
179408016084	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408016085	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
179408016086	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408016087	ATP binding site [chemical binding]; other site
179408016088	Mg2+ binding site [ion binding]; other site
179408016089	G-X-G motif; other site
179408016090	Response regulator receiver domain; Region: Response_reg; pfam00072
179408016091	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408016092	active site
179408016093	phosphorylation site [posttranslational modification]
179408016094	intermolecular recognition site; other site
179408016095	dimerization interface [polypeptide binding]; other site
179408016096	Response regulator receiver domain; Region: Response_reg; pfam00072
179408016097	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408016098	active site
179408016099	phosphorylation site [posttranslational modification]
179408016100	intermolecular recognition site; other site
179408016101	dimerization interface [polypeptide binding]; other site
179408016102	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408016103	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408016104	active site
179408016105	phosphorylation site [posttranslational modification]
179408016106	intermolecular recognition site; other site
179408016107	dimerization interface [polypeptide binding]; other site
179408016108	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
179408016109	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
179408016110	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
179408016111	CheB methylesterase; Region: CheB_methylest; pfam01339
179408016112	Response regulator receiver domain; Region: Response_reg; pfam00072
179408016113	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408016114	active site
179408016115	phosphorylation site [posttranslational modification]
179408016116	intermolecular recognition site; other site
179408016117	dimerization interface [polypeptide binding]; other site
179408016118	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408016119	putative active site [active]
179408016120	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408016121	heme pocket [chemical binding]; other site
179408016122	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408016123	dimer interface [polypeptide binding]; other site
179408016124	phosphorylation site [posttranslational modification]
179408016125	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408016126	ATP binding site [chemical binding]; other site
179408016127	Mg2+ binding site [ion binding]; other site
179408016128	G-X-G motif; other site
179408016129	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408016130	Response regulator receiver domain; Region: Response_reg; pfam00072
179408016131	active site
179408016132	phosphorylation site [posttranslational modification]
179408016133	intermolecular recognition site; other site
179408016134	dimerization interface [polypeptide binding]; other site
179408016135	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
179408016136	active site
179408016137	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
179408016138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408016139	active site
179408016140	phosphorylation site [posttranslational modification]
179408016141	intermolecular recognition site; other site
179408016142	dimerization interface [polypeptide binding]; other site
179408016143	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
179408016144	DNA binding residues [nucleotide binding]
179408016145	dimerization interface [polypeptide binding]; other site
179408016146	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408016147	WD domain, G-beta repeat; Region: WD40; pfam00400
179408016148	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408016149	structural tetrad; other site
179408016150	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408016151	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408016152	structural tetrad; other site
179408016153	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
179408016154	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
179408016155	molybdopterin cofactor binding site; other site
179408016156	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
179408016157	molybdopterin cofactor binding site; other site
179408016158	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408016159	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408016160	active site
179408016161	ATP binding site [chemical binding]; other site
179408016162	substrate binding site [chemical binding]; other site
179408016163	activation loop (A-loop); other site
179408016164	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408016165	structural tetrad; other site
179408016166	PQQ-like domain; Region: PQQ_2; pfam13360
179408016167	Transmembrane proteins 14C; Region: Tmemb_14; cl02346
179408016168	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
179408016169	Protein of unknown function (DUF815); Region: DUF815; pfam05673
179408016170	tellurite resistance protein terB; Region: terB; cd07176
179408016171	putative metal binding site [ion binding]; other site
179408016172	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
179408016173	active site
179408016174	2-dehydropantoate 2-reductase; Provisional; Region: PRK06249
179408016175	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
179408016176	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
179408016177	O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445
179408016178	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
179408016179	acyl-activating enzyme (AAE) consensus motif; other site
179408016180	putative AMP binding site [chemical binding]; other site
179408016181	putative active site [active]
179408016182	putative CoA binding site [chemical binding]; other site
179408016183	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
179408016184	o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927
179408016185	active site
179408016186	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
179408016187	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
179408016188	catalytic motif [active]
179408016189	Catalytic residue [active]
179408016190	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419
179408016191	UbiA prenyltransferase family; Region: UbiA; pfam01040
179408016192	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
179408016193	chorismate binding enzyme; Region: Chorismate_bind; cl10555
179408016194	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
179408016195	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
179408016196	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
179408016197	dimer interface [polypeptide binding]; other site
179408016198	tetramer interface [polypeptide binding]; other site
179408016199	PYR/PP interface [polypeptide binding]; other site
179408016200	TPP binding site [chemical binding]; other site
179408016201	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
179408016202	TPP-binding site; other site
179408016203	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
179408016204	GSH binding site [chemical binding]; other site
179408016205	catalytic residues [active]
179408016206	WYL domain; Region: WYL; pfam13280
179408016207	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
179408016208	active site
179408016209	NTP binding site [chemical binding]; other site
179408016210	metal binding triad [ion binding]; metal-binding site
179408016211	antibiotic binding site [chemical binding]; other site
179408016212	Protein of unknown function DUF86; Region: DUF86; pfam01934
179408016213	CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cl11869
179408016214	CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711
179408016215	CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159
179408016216	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
179408016217	CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158
179408016218	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
179408016219	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
179408016220	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
179408016221	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
179408016222	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
179408016223	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
179408016224	FMN binding site [chemical binding]; other site
179408016225	active site
179408016226	substrate binding site [chemical binding]; other site
179408016227	catalytic residue [active]
179408016228	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
179408016229	light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810
179408016230	putative NAD(P) binding site [chemical binding]; other site
179408016231	active site
179408016232	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
179408016233	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
179408016234	Surface antigen; Region: Bac_surface_Ag; pfam01103
179408016235	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408016236	putative active site [active]
179408016237	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
179408016238	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
179408016239	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
179408016240	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
179408016241	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408016242	binding surface
179408016243	TPR motif; other site
179408016244	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408016245	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
179408016246	Protein of unknown function (DUF422); Region: DUF422; cl00991
179408016247	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
179408016248	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
179408016249	active site
179408016250	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408016251	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
179408016252	Family description; Region: VCBS; pfam13517
179408016253	Family description; Region: VCBS; pfam13517
179408016254	Family description; Region: VCBS; pfam13517
179408016255	Family description; Region: VCBS; pfam13517
179408016256	FG-GAP repeat; Region: FG-GAP; pfam01839
179408016257	Family description; Region: VCBS; pfam13517
179408016258	Family description; Region: VCBS; pfam13517
179408016259	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408016260	TIGR03032 family protein; Region: TIGR03032
179408016261	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408016262	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408016263	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408016264	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408016265	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408016266	Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453
179408016267	active site
179408016268	catalytic residues [active]
179408016269	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
179408016270	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
179408016271	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408016272	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408016273	G-X-G motif; other site
179408016274	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408016275	salt bridge; other site
179408016276	non-specific DNA binding site [nucleotide binding]; other site
179408016277	sequence-specific DNA binding site [nucleotide binding]; other site
179408016278	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
179408016279	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
179408016280	putative NAD(P) binding site [chemical binding]; other site
179408016281	MAPEG family; Region: MAPEG; pfam01124
179408016282	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
179408016283	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
179408016284	RNA/DNA hybrid binding site [nucleotide binding]; other site
179408016285	active site
179408016286	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
179408016287	haemagglutination activity domain; Region: Haemagg_act; pfam05860
179408016288	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
179408016289	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
179408016290	Acyltransferase family; Region: Acyl_transf_3; pfam01757
179408016291	ribonuclease PH; Reviewed; Region: rph; PRK00173
179408016292	Ribonuclease PH; Region: RNase_PH_bact; cd11362
179408016293	hexamer interface [polypeptide binding]; other site
179408016294	active site
179408016295	adenylate kinase; Reviewed; Region: adk; PRK00279
179408016296	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
179408016297	AMP-binding site [chemical binding]; other site
179408016298	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
179408016299	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
179408016300	HAMP domain; Region: HAMP; pfam00672
179408016301	dimerization interface [polypeptide binding]; other site
179408016302	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408016303	dimer interface [polypeptide binding]; other site
179408016304	phosphorylation site [posttranslational modification]
179408016305	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408016306	ATP binding site [chemical binding]; other site
179408016307	Mg2+ binding site [ion binding]; other site
179408016308	G-X-G motif; other site
179408016309	Response regulator receiver domain; Region: Response_reg; pfam00072
179408016310	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408016311	active site
179408016312	phosphorylation site [posttranslational modification]
179408016313	intermolecular recognition site; other site
179408016314	dimerization interface [polypeptide binding]; other site
179408016315	Response regulator receiver domain; Region: Response_reg; pfam00072
179408016316	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408016317	active site
179408016318	phosphorylation site [posttranslational modification]
179408016319	intermolecular recognition site; other site
179408016320	dimerization interface [polypeptide binding]; other site
179408016321	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
179408016322	dimer interface [polypeptide binding]; other site
179408016323	phosphorylation site [posttranslational modification]
179408016324	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408016325	ATP binding site [chemical binding]; other site
179408016326	Mg2+ binding site [ion binding]; other site
179408016327	G-X-G motif; other site
179408016328	Ubiquitin-like proteins; Region: UBQ; cl00155
179408016329	ribosome maturation protein RimP; Reviewed; Region: PRK00092
179408016330	Sm and related proteins; Region: Sm_like; cl00259
179408016331	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
179408016332	putative oligomer interface [polypeptide binding]; other site
179408016333	putative RNA binding site [nucleotide binding]; other site
179408016334	NusA N-terminal domain; Region: NusA_N; pfam08529
179408016335	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
179408016336	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
179408016337	RNA binding site [nucleotide binding]; other site
179408016338	homodimer interface [polypeptide binding]; other site
179408016339	NusA-like KH domain; Region: KH_5; pfam13184
179408016340	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
179408016341	G-X-X-G motif; other site
179408016342	Protein of unknown function (DUF448); Region: DUF448; pfam04296
179408016343	putative RNA binding cleft [nucleotide binding]; other site
179408016344	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
179408016345	translation initiation factor IF-2; Region: IF-2; TIGR00487
179408016346	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
179408016347	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
179408016348	G1 box; other site
179408016349	putative GEF interaction site [polypeptide binding]; other site
179408016350	GTP/Mg2+ binding site [chemical binding]; other site
179408016351	Switch I region; other site
179408016352	G2 box; other site
179408016353	G3 box; other site
179408016354	Switch II region; other site
179408016355	G4 box; other site
179408016356	G5 box; other site
179408016357	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
179408016358	Translation-initiation factor 2; Region: IF-2; pfam11987
179408016359	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
179408016360	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
179408016361	putative ADP-binding pocket [chemical binding]; other site
179408016362	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
179408016363	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
179408016364	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
179408016365	inhibitor-cofactor binding pocket; inhibition site
179408016366	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408016367	catalytic residue [active]
179408016368	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
179408016369	Protein of unknown function (DUF3493); Region: DUF3493; pfam11998
179408016370	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408016371	Probable transposase; Region: OrfB_IS605; pfam01385
179408016372	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408016373	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
179408016374	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
179408016375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408016376	S-adenosylmethionine binding site [chemical binding]; other site
179408016377	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408016378	Response regulator receiver domain; Region: Response_reg; pfam00072
179408016379	active site
179408016380	phosphorylation site [posttranslational modification]
179408016381	intermolecular recognition site; other site
179408016382	dimerization interface [polypeptide binding]; other site
179408016383	GAF domain; Region: GAF; pfam01590
179408016384	GAF domain; Region: GAF_2; pfam13185
179408016385	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
179408016386	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
179408016387	Family description; Region: UvrD_C_2; pfam13538
179408016388	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408016389	binding surface
179408016390	TPR motif; other site
179408016391	TPR repeat; Region: TPR_11; pfam13414
179408016392	TPR repeat; Region: TPR_11; pfam13414
179408016393	Tetratricopeptide repeat; Region: TPR_1; pfam00515
179408016394	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
179408016395	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408016396	binding surface
179408016397	TPR motif; other site
179408016398	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
179408016399	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408016400	binding surface
179408016401	TPR motif; other site
179408016402	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408016403	binding surface
179408016404	TPR motif; other site
179408016405	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
179408016406	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
179408016407	active site
179408016408	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
179408016409	CHASE2 domain; Region: CHASE2; pfam05226
179408016410	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408016411	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408016412	metal binding site [ion binding]; metal-binding site
179408016413	active site
179408016414	I-site; other site
179408016415	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
179408016416	dihydrodipicolinate reductase; Provisional; Region: PRK00048
179408016417	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
179408016418	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
179408016419	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
179408016420	Protein export membrane protein; Region: SecD_SecF; cl14618
179408016421	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
179408016422	Protein export membrane protein; Region: SecD_SecF; cl14618
179408016423	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
179408016424	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
179408016425	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
179408016426	HlyD family secretion protein; Region: HlyD_3; pfam13437
179408016427	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
179408016428	Histidine kinase; Region: HisKA_3; pfam07730
179408016429	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408016430	ATP binding site [chemical binding]; other site
179408016431	Mg2+ binding site [ion binding]; other site
179408016432	G-X-G motif; other site
179408016433	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
179408016434	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408016435	active site
179408016436	phosphorylation site [posttranslational modification]
179408016437	intermolecular recognition site; other site
179408016438	dimerization interface [polypeptide binding]; other site
179408016439	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
179408016440	DNA binding residues [nucleotide binding]
179408016441	dimerization interface [polypeptide binding]; other site
179408016442	precorrin-8X methylmutase; Validated; Region: PRK05953
179408016443	Precorrin-8X methylmutase; Region: CbiC; pfam02570
179408016444	Repair protein; Region: Repair_PSII; pfam04536
179408016445	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
179408016446	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
179408016447	Uncharacterized conserved protein [Function unknown]; Region: COG3391
179408016448	Opioid growth factor receptor (OGFr) conserved region; Region: OGFr_N; pfam04664
179408016449	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
179408016450	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
179408016451	DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864
179408016452	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
179408016453	active site
179408016454	substrate binding site [chemical binding]; other site
179408016455	Mg2+ binding site [ion binding]; other site
179408016456	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408016457	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408016458	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408016459	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408016460	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408016461	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408016462	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408016463	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408016464	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
179408016465	Protein of unknown function, DUF258; Region: DUF258; pfam03193
179408016466	WD domain, G-beta repeat; Region: WD40; pfam00400
179408016467	WD40 repeats; Region: WD40; smart00320
179408016468	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408016469	structural tetrad; other site
179408016470	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408016471	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408016472	structural tetrad; other site
179408016473	WD40 repeats; Region: WD40; smart00320
179408016474	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
179408016475	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
179408016476	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
179408016477	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408016478	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408016479	Probable transposase; Region: OrfB_IS605; pfam01385
179408016480	cell division protein FtsZ; Validated; Region: PRK09330
179408016481	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
179408016482	nucleotide binding site [chemical binding]; other site
179408016483	SulA interaction site; other site
179408016484	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
179408016485	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
179408016486	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
179408016487	dimer interface [polypeptide binding]; other site
179408016488	substrate binding site [chemical binding]; other site
179408016489	ATP binding site [chemical binding]; other site
179408016490	Domain of unknown function (DUF1832); Region: DUF1832; pfam08870
179408016491	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
179408016492	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408016493	Walker A/P-loop; other site
179408016494	ATP binding site [chemical binding]; other site
179408016495	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408016496	Q-loop/lid; other site
179408016497	ABC transporter signature motif; other site
179408016498	Walker B; other site
179408016499	D-loop; other site
179408016500	H-loop/switch region; other site
179408016501	Transposase IS200 like; Region: Y1_Tnp; pfam01797
179408016502	hypothetical protein; Provisional; Region: PRK06850
179408016503	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
179408016504	Active Sites [active]
179408016505	DNA-sulfur modification-associated; Region: DndB; pfam14072
179408016506	DNA-sulfur modification-associated; Region: DndB; cl17621
179408016507	DGQHR domain; Region: DGQHR; TIGR03187
179408016508	DGQHR domain; Region: DGQHR; TIGR03187
179408016509	DNA-sulfur modification-associated; Region: DndB; cl17621
179408016510	Staphylococcal nuclease homologues; Region: SNc; smart00318
179408016511	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
179408016512	Catalytic site; other site
179408016513	Caspase domain; Region: Peptidase_C14; pfam00656
179408016514	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352
179408016515	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
179408016516	active site
179408016517	catalytic site [active]
179408016518	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK06406
179408016519	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
179408016520	putative catalytic site [active]
179408016521	putative metal binding site [ion binding]; other site
179408016522	putative phosphate binding site [ion binding]; other site
179408016523	dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062
179408016524	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532
179408016525	metal binding site [ion binding]; metal-binding site
179408016526	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408016527	putative active site [active]
179408016528	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408016529	putative active site [active]
179408016530	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
179408016531	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408016532	Walker A/P-loop; other site
179408016533	ATP binding site [chemical binding]; other site
179408016534	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
179408016535	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
179408016536	ATP binding site [chemical binding]; other site
179408016537	putative Mg++ binding site [ion binding]; other site
179408016538	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
179408016539	nucleotide binding region [chemical binding]; other site
179408016540	ATP-binding site [chemical binding]; other site
179408016541	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408016542	putative active site [active]
179408016543	Uncharacterized conserved protein [Function unknown]; Region: COG3937
179408016544	YCII-related domain; Region: YCII; cl00999
179408016545	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408016546	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408016547	Probable transposase; Region: OrfB_IS605; pfam01385
179408016548	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
179408016549	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
179408016550	Domain of unknown function (DUF329); Region: DUF329; cl01144
179408016551	comF family protein; Region: comF; TIGR00201
179408016552	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
179408016553	active site
179408016554	phosphoenolpyruvate synthase; Region: PEP_synth; TIGR01418
179408016555	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
179408016556	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
179408016557	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
179408016558	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
179408016559	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
179408016560	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
179408016561	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
179408016562	putative active site [active]
179408016563	putative dimer interface [polypeptide binding]; other site
179408016564	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
179408016565	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
179408016566	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
179408016567	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
179408016568	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
179408016569	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
179408016570	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
179408016571	DNA methylase; Region: N6_N4_Mtase; cl17433
179408016572	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
179408016573	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319
179408016574	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
179408016575	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
179408016576	dimerization interface [polypeptide binding]; other site
179408016577	active site
179408016578	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408016579	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408016580	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408016581	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408016582	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408016583	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408016584	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408016585	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408016586	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408016587	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408016588	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408016589	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408016590	HAS barrel domain; Region: HAS-barrel; pfam09378
179408016591	HerA helicase [Replication, recombination, and repair]; Region: COG0433
179408016592	Domain of unknown function DUF87; Region: DUF87; pfam01935
179408016593	RNA polymerase sigma factor; Validated; Region: PRK05949
179408016594	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
179408016595	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
179408016596	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
179408016597	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
179408016598	DNA binding residues [nucleotide binding]
179408016599	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322
179408016600	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408016601	dimerization interface [polypeptide binding]; other site
179408016602	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408016603	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408016604	putative active site [active]
179408016605	heme pocket [chemical binding]; other site
179408016606	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408016607	putative active site [active]
179408016608	heme pocket [chemical binding]; other site
179408016609	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408016610	dimer interface [polypeptide binding]; other site
179408016611	phosphorylation site [posttranslational modification]
179408016612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408016613	ATP binding site [chemical binding]; other site
179408016614	Mg2+ binding site [ion binding]; other site
179408016615	G-X-G motif; other site
179408016616	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
179408016617	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
179408016618	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
179408016619	homodimer interface [polypeptide binding]; other site
179408016620	Walker A motif; other site
179408016621	ATP binding site [chemical binding]; other site
179408016622	hydroxycobalamin binding site [chemical binding]; other site
179408016623	Walker B motif; other site
179408016624	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408016625	putative active site [active]
179408016626	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
179408016627	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
179408016628	dimer interface [polypeptide binding]; other site
179408016629	putative functional site; other site
179408016630	putative MPT binding site; other site
179408016631	Response regulator receiver domain; Region: Response_reg; pfam00072
179408016632	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408016633	active site
179408016634	phosphorylation site [posttranslational modification]
179408016635	intermolecular recognition site; other site
179408016636	dimerization interface [polypeptide binding]; other site
179408016637	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
179408016638	DNA binding residues [nucleotide binding]
179408016639	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
179408016640	RimM N-terminal domain; Region: RimM; pfam01782
179408016641	PRC-barrel domain; Region: PRC; pfam05239
179408016642	Predicted membrane protein [Function unknown]; Region: COG3431
179408016643	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
179408016644	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
179408016645	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
179408016646	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
179408016647	[4Fe-4S] binding site [ion binding]; other site
179408016648	molybdopterin cofactor binding site; other site
179408016649	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
179408016650	molybdopterin cofactor binding site; other site
179408016651	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
179408016652	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
179408016653	Walker A/P-loop; other site
179408016654	ATP binding site [chemical binding]; other site
179408016655	Q-loop/lid; other site
179408016656	ABC transporter signature motif; other site
179408016657	Walker B; other site
179408016658	D-loop; other site
179408016659	H-loop/switch region; other site
179408016660	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
179408016661	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
179408016662	Walker A/P-loop; other site
179408016663	ATP binding site [chemical binding]; other site
179408016664	Q-loop/lid; other site
179408016665	ABC transporter signature motif; other site
179408016666	Walker B; other site
179408016667	D-loop; other site
179408016668	H-loop/switch region; other site
179408016669	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
179408016670	NMT1-like family; Region: NMT1_2; pfam13379
179408016671	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
179408016672	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408016673	dimer interface [polypeptide binding]; other site
179408016674	conserved gate region; other site
179408016675	putative PBP binding loops; other site
179408016676	ABC-ATPase subunit interface; other site
179408016677	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
179408016678	NMT1-like family; Region: NMT1_2; pfam13379
179408016679	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
179408016680	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
179408016681	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
179408016682	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
179408016683	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
179408016684	catalytic loop [active]
179408016685	iron binding site [ion binding]; other site
179408016686	Uncharacterized conserved protein [Function unknown]; Region: COG0432
179408016687	Family description; Region: VCBS; pfam13517
179408016688	Family description; Region: VCBS; pfam13517
179408016689	Calx-beta domain; Region: Calx-beta; cl02522
179408016690	Calx-beta domain; Region: Calx-beta; cl02522
179408016691	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408016692	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408016693	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
179408016694	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408016695	putative active site [active]
179408016696	putative NTP binding site [chemical binding]; other site
179408016697	putative nucleic acid binding site [nucleotide binding]; other site
179408016698	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408016699	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408016700	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408016701	active site
179408016702	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
179408016703	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
179408016704	Family description; Region: VCBS; pfam13517
179408016705	Family description; Region: VCBS; pfam13517
179408016706	Family description; Region: VCBS; pfam13517
179408016707	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
179408016708	putative active site [active]
179408016709	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
179408016710	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
179408016711	catalytic triad [active]
179408016712	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
179408016713	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
179408016714	tetramer interface [polypeptide binding]; other site
179408016715	heme binding pocket [chemical binding]; other site
179408016716	NADPH binding site [chemical binding]; other site
179408016717	AAA ATPase domain; Region: AAA_16; pfam13191
179408016718	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
179408016719	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
179408016720	metal ion-dependent adhesion site (MIDAS); other site
179408016721	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
179408016722	active site
179408016723	TPR repeat; Region: TPR_11; pfam13414
179408016724	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408016725	binding surface
179408016726	TPR motif; other site
179408016727	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408016728	substrate binding site [chemical binding]; other site
179408016729	activation loop (A-loop); other site
179408016730	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
179408016731	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
179408016732	HIGH motif; other site
179408016733	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
179408016734	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
179408016735	active site
179408016736	KMSKS motif; other site
179408016737	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
179408016738	tRNA binding surface [nucleotide binding]; other site
179408016739	anticodon binding site; other site
179408016740	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
179408016741	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
179408016742	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
179408016743	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
179408016744	folate binding site [chemical binding]; other site
179408016745	NADP+ binding site [chemical binding]; other site
179408016746	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
179408016747	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
179408016748	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
179408016749	dimerization interface [polypeptide binding]; other site
179408016750	substrate binding pocket [chemical binding]; other site
179408016751	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
179408016752	Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909
179408016753	active site
179408016754	Zn binding site [ion binding]; other site
179408016755	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
179408016756	active site
179408016757	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
179408016758	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
179408016759	Peptidase family M23; Region: Peptidase_M23; pfam01551
179408016760	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408016761	Probable transposase; Region: OrfB_IS605; pfam01385
179408016762	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408016763	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408016764	putative active site [active]
179408016765	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
179408016766	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
179408016767	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
179408016768	dimer interface [polypeptide binding]; other site
179408016769	[2Fe-2S] cluster binding site [ion binding]; other site
179408016770	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
179408016771	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
179408016772	dimerization interface [polypeptide binding]; other site
179408016773	DPS ferroxidase diiron center [ion binding]; other site
179408016774	ion pore; other site
179408016775	geranylgeranyl reductase; Region: ChlP; TIGR02028
179408016776	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
179408016777	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
179408016778	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408016779	active site
179408016780	ATP binding site [chemical binding]; other site
179408016781	substrate binding site [chemical binding]; other site
179408016782	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408016783	activation loop (A-loop); other site
179408016784	AAA ATPase domain; Region: AAA_16; pfam13191
179408016785	Predicted ATPase [General function prediction only]; Region: COG3899
179408016786	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408016787	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408016788	cyclase homology domain; Region: CHD; cd07302
179408016789	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
179408016790	nucleotidyl binding site; other site
179408016791	metal binding site [ion binding]; metal-binding site
179408016792	dimer interface [polypeptide binding]; other site
179408016793	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
179408016794	legume lectins; Region: lectin_L-type; cl14058
179408016795	carbohydrate binding site [chemical binding]; other site
179408016796	metal binding site [ion binding]; metal-binding site
179408016797	homotetramer interaction site [polypeptide binding]; other site
179408016798	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
179408016799	haemagglutination activity domain; Region: Haemagg_act; pfam05860
179408016800	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
179408016801	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
179408016802	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408016803	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408016804	active site
179408016805	ATP binding site [chemical binding]; other site
179408016806	substrate binding site [chemical binding]; other site
179408016807	activation loop (A-loop); other site
179408016808	AAA ATPase domain; Region: AAA_16; pfam13191
179408016809	Predicted ATPase [General function prediction only]; Region: COG3899
179408016810	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408016811	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408016812	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408016813	PAS domain; Region: PAS_9; pfam13426
179408016814	putative active site [active]
179408016815	heme pocket [chemical binding]; other site
179408016816	cyclase homology domain; Region: CHD; cd07302
179408016817	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
179408016818	nucleotidyl binding site; other site
179408016819	metal binding site [ion binding]; metal-binding site
179408016820	dimer interface [polypeptide binding]; other site
179408016821	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
179408016822	Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and  L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635
179408016823	ATP-grasp domain; Region: ATP-grasp_4; cl17255
179408016824	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408016825	binding surface
179408016826	TPR motif; other site
179408016827	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
179408016828	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408016829	binding surface
179408016830	TPR motif; other site
179408016831	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408016832	binding surface
179408016833	TPR motif; other site
179408016834	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408016835	binding surface
179408016836	TPR motif; other site
179408016837	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408016838	binding surface
179408016839	TPR motif; other site
179408016840	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408016841	binding surface
179408016842	TPR motif; other site
179408016843	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408016844	binding surface
179408016845	TPR motif; other site
179408016846	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408016847	binding surface
179408016848	TPR motif; other site
179408016849	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408016850	binding surface
179408016851	TPR motif; other site
179408016852	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
179408016853	Ligand Binding Site [chemical binding]; other site
179408016854	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
179408016855	histidinol dehydrogenase; Region: hisD; TIGR00069
179408016856	NAD binding site [chemical binding]; other site
179408016857	dimerization interface [polypeptide binding]; other site
179408016858	product binding site; other site
179408016859	substrate binding site [chemical binding]; other site
179408016860	zinc binding site [ion binding]; other site
179408016861	catalytic residues [active]
179408016862	ribosomal protein S20; Region: rps20; CHL00102
179408016863	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
179408016864	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
179408016865	active site
179408016866	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
179408016867	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
179408016868	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
179408016869	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
179408016870	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
179408016871	RPB10 interaction site [polypeptide binding]; other site
179408016872	RPB1 interaction site [polypeptide binding]; other site
179408016873	RPB11 interaction site [polypeptide binding]; other site
179408016874	RPB3 interaction site [polypeptide binding]; other site
179408016875	RPB12 interaction site [polypeptide binding]; other site
179408016876	HNH endonuclease; Region: HNH_3; pfam13392
179408016877	HNH endonuclease; Region: HNH_3; pfam13392
179408016878	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
179408016879	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
179408016880	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
179408016881	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
179408016882	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
179408016883	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
179408016884	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
179408016885	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
179408016886	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
179408016887	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
179408016888	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
179408016889	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
179408016890	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
179408016891	DNA binding site [nucleotide binding]
179408016892	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
179408016893	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408016894	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408016895	active site
179408016896	phosphorylation site [posttranslational modification]
179408016897	intermolecular recognition site; other site
179408016898	dimerization interface [polypeptide binding]; other site
179408016899	DNA gyrase subunit A; Validated; Region: PRK05560
179408016900	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
179408016901	CAP-like domain; other site
179408016902	active site
179408016903	primary dimer interface [polypeptide binding]; other site
179408016904	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
179408016905	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
179408016906	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
179408016907	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408016908	AAA domain; Region: AAA_21; pfam13304
179408016909	Walker A/P-loop; other site
179408016910	ATP binding site [chemical binding]; other site
179408016911	Q-loop/lid; other site
179408016912	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408016913	ABC transporter signature motif; other site
179408016914	Walker B; other site
179408016915	D-loop; other site
179408016916	H-loop/switch region; other site
179408016917	TOBE domain; Region: TOBE_2; pfam08402
179408016918	light-harvesting-like protein 3; Provisional; Region: PLN00014
179408016919	RNA polymerase sigma factor RpoD; Validated; Region: PRK07406
179408016920	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
179408016921	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
179408016922	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
179408016923	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
179408016924	DNA binding residues [nucleotide binding]
179408016925	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
179408016926	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408016927	dimer interface [polypeptide binding]; other site
179408016928	conserved gate region; other site
179408016929	ABC-ATPase subunit interface; other site
179408016930	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
179408016931	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
179408016932	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
179408016933	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
179408016934	Low molecular weight phosphatase family; Region: LMWPc; cl00105
179408016935	active site
179408016936	Methyltransferase domain; Region: Methyltransf_31; pfam13847
179408016937	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408016938	S-adenosylmethionine binding site [chemical binding]; other site
179408016939	Uncharacterized conserved protein [Function unknown]; Region: COG1262
179408016940	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
179408016941	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408016942	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408016943	metal binding site [ion binding]; metal-binding site
179408016944	active site
179408016945	I-site; other site
179408016946	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
179408016947	YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524
179408016948	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
179408016949	active site
179408016950	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408016951	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
179408016952	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
179408016953	TrkA-N domain; Region: TrkA_N; pfam02254
179408016954	Methyltransferase domain; Region: Methyltransf_31; pfam13847
179408016955	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408016956	S-adenosylmethionine binding site [chemical binding]; other site
179408016957	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408016958	putative active site [active]
179408016959	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408016960	putative active site [active]
179408016961	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
179408016962	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
179408016963	TPP-binding site [chemical binding]; other site
179408016964	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
179408016965	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
179408016966	Circadian oscillating protein COP23; Region: COP23; pfam14218
179408016967	Circadian oscillating protein COP23; Region: COP23; pfam14218
179408016968	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
179408016969	Cytochrome P450; Region: p450; pfam00067
179408016970	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
179408016971	MoaE interaction surface [polypeptide binding]; other site
179408016972	MoeB interaction surface [polypeptide binding]; other site
179408016973	thiocarboxylated glycine; other site
179408016974	threonine synthase; Validated; Region: PRK07591
179408016975	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
179408016976	homodimer interface [polypeptide binding]; other site
179408016977	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408016978	catalytic residue [active]
179408016979	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
179408016980	MoaE interaction surface [polypeptide binding]; other site
179408016981	MoeB interaction surface [polypeptide binding]; other site
179408016982	thiocarboxylated glycine; other site
179408016983	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
179408016984	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
179408016985	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
179408016986	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
179408016987	dihydrodipicolinate synthase; Region: dapA; TIGR00674
179408016988	dimer interface [polypeptide binding]; other site
179408016989	active site
179408016990	catalytic residue [active]
179408016991	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
179408016992	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
179408016993	trigger factor; Provisional; Region: tig; PRK01490
179408016994	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
179408016995	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
179408016996	Clp protease; Region: CLP_protease; pfam00574
179408016997	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
179408016998	oligomer interface [polypeptide binding]; other site
179408016999	active site residues [active]
179408017000	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
179408017001	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
179408017002	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
179408017003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408017004	Walker A motif; other site
179408017005	ATP binding site [chemical binding]; other site
179408017006	Walker B motif; other site
179408017007	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
179408017008	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948
179408017009	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408017010	Walker A motif; other site
179408017011	ATP binding site [chemical binding]; other site
179408017012	Walker B motif; other site
179408017013	arginine finger; other site
179408017014	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
179408017015	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
179408017016	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
179408017017	Walker A/P-loop; other site
179408017018	ATP binding site [chemical binding]; other site
179408017019	Q-loop/lid; other site
179408017020	ABC transporter signature motif; other site
179408017021	Walker B; other site
179408017022	D-loop; other site
179408017023	H-loop/switch region; other site
179408017024	Putative restriction endonuclease; Region: Uma2; pfam05685
179408017025	DevC protein; Region: devC; TIGR01185
179408017026	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
179408017027	FtsX-like permease family; Region: FtsX; pfam02687
179408017028	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
179408017029	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
179408017030	HlyD family secretion protein; Region: HlyD_3; pfam13437
179408017031	phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816
179408017032	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
179408017033	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
179408017034	oligomerization interface [polypeptide binding]; other site
179408017035	active site
179408017036	metal binding site [ion binding]; metal-binding site
179408017037	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408017038	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408017039	active site
179408017040	ATP binding site [chemical binding]; other site
179408017041	substrate binding site [chemical binding]; other site
179408017042	activation loop (A-loop); other site
179408017043	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040
179408017044	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
179408017045	homodimer interface [polypeptide binding]; other site
179408017046	active site
179408017047	heterodimer interface [polypeptide binding]; other site
179408017048	catalytic residue [active]
179408017049	metal binding site [ion binding]; metal-binding site
179408017050	RbcX protein; Region: RcbX; pfam02341
179408017051	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
179408017052	multimerization interface [polypeptide binding]; other site
179408017053	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408017054	binding surface
179408017055	TPR motif; other site
179408017056	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408017057	binding surface
179408017058	TPR repeat; Region: TPR_11; pfam13414
179408017059	TPR motif; other site
179408017060	TPR repeat; Region: TPR_11; pfam13414
179408017061	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408017062	binding surface
179408017063	TPR repeat; Region: TPR_11; pfam13414
179408017064	TPR motif; other site
179408017065	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408017066	binding surface
179408017067	TPR repeat; Region: TPR_11; pfam13414
179408017068	TPR motif; other site
179408017069	TPR repeat; Region: TPR_11; pfam13414
179408017070	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408017071	binding surface
179408017072	TPR motif; other site
179408017073	TPR repeat; Region: TPR_11; pfam13414
179408017074	TPR repeat; Region: TPR_11; pfam13414
179408017075	Tetratricopeptide repeat; Region: TPR_1; pfam00515
179408017076	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408017077	binding surface
179408017078	TPR repeat; Region: TPR_11; pfam13414
179408017079	TPR motif; other site
179408017080	TPR repeat; Region: TPR_11; pfam13414
179408017081	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408017082	binding surface
179408017083	TPR repeat; Region: TPR_11; pfam13414
179408017084	TPR motif; other site
179408017085	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408017086	binding surface
179408017087	TPR repeat; Region: TPR_11; pfam13414
179408017088	TPR motif; other site
179408017089	TPR repeat; Region: TPR_11; pfam13414
179408017090	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408017091	binding surface
179408017092	TPR repeat; Region: TPR_11; pfam13414
179408017093	TPR motif; other site
179408017094	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
179408017095	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408017096	binding surface
179408017097	TPR motif; other site
179408017098	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408017099	binding surface
179408017100	TPR motif; other site
179408017101	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408017102	putative active site [active]
179408017103	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
179408017104	active site
179408017105	putative DNA-binding cleft [nucleotide binding]; other site
179408017106	dimer interface [polypeptide binding]; other site
179408017107	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
179408017108	AAA ATPase domain; Region: AAA_16; pfam13191
179408017109	Walker A motif; other site
179408017110	ATP binding site [chemical binding]; other site
179408017111	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
179408017112	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
179408017113	Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051
179408017114	catalytic site [active]
179408017115	SurA N-terminal domain; Region: SurA_N; pfam09312
179408017116	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
179408017117	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
179408017118	oligomeric interface; other site
179408017119	putative active site [active]
179408017120	homodimer interface [polypeptide binding]; other site
179408017121	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
179408017122	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
179408017123	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
179408017124	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
179408017125	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
179408017126	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408017127	binding surface
179408017128	TPR motif; other site
179408017129	TPR repeat; Region: TPR_11; pfam13414
179408017130	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
179408017131	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
179408017132	cobalamin binding residues [chemical binding]; other site
179408017133	putative BtuC binding residues; other site
179408017134	dimer interface [polypeptide binding]; other site
179408017135	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
179408017136	Fasciclin domain; Region: Fasciclin; pfam02469
179408017137	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
179408017138	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
179408017139	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
179408017140	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
179408017141	glutamine binding [chemical binding]; other site
179408017142	catalytic triad [active]
179408017143	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
179408017144	metal-binding heat shock protein; Provisional; Region: PRK00016
179408017145	Protein of unknown function (DUF3285); Region: DUF3285; pfam11688
179408017146	Protein of unknown function (DUF4058); Region: DUF4058; pfam13267
179408017147	Protein of unknown function (DUF4058); Region: DUF4058; pfam13267
179408017148	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
179408017149	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
179408017150	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
179408017151	active site
179408017152	dimer interface [polypeptide binding]; other site
179408017153	motif 1; other site
179408017154	motif 2; other site
179408017155	motif 3; other site
179408017156	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
179408017157	anticodon binding site; other site
179408017158	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408017159	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408017160	Probable transposase; Region: OrfB_IS605; pfam01385
179408017161	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408017162	Protein of unknown function (DUF2605); Region: DUF2605; pfam10792
179408017163	Protein of unknown function (DUF2973); Region: DUF2973; pfam11189
179408017164	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
179408017165	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408017166	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408017167	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408017168	dimer interface [polypeptide binding]; other site
179408017169	phosphorylation site [posttranslational modification]
179408017170	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408017171	ATP binding site [chemical binding]; other site
179408017172	Mg2+ binding site [ion binding]; other site
179408017173	G-X-G motif; other site
179408017174	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
179408017175	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408017176	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408017177	PsaD; Region: PsaD; pfam02531
179408017178	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
179408017179	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408017180	Coenzyme A binding pocket [chemical binding]; other site
179408017181	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
179408017182	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
179408017183	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
179408017184	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408017185	putative active site [active]
179408017186	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
179408017187	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
179408017188	homoserine dehydrogenase; Provisional; Region: PRK06349
179408017189	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
179408017190	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
179408017191	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
179408017192	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408017193	putative active site [active]
179408017194	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
179408017195	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
179408017196	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
179408017197	dimerization interface [polypeptide binding]; other site
179408017198	FAD binding pocket [chemical binding]; other site
179408017199	FAD binding motif [chemical binding]; other site
179408017200	catalytic residues [active]
179408017201	NAD binding pocket [chemical binding]; other site
179408017202	phosphate binding motif [ion binding]; other site
179408017203	beta-alpha-beta structure motif; other site
179408017204	phosphoribulokinase; Provisional; Region: PRK07429
179408017205	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
179408017206	active site
179408017207	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
179408017208	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
179408017209	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408017210	Walker A motif; other site
179408017211	ATP binding site [chemical binding]; other site
179408017212	Walker B motif; other site
179408017213	arginine finger; other site
179408017214	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
179408017215	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
179408017216	GxxExxY protein; Region: GxxExxY; TIGR04256
179408017217	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
179408017218	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
179408017219	HIGH motif; other site
179408017220	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
179408017221	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
179408017222	active site
179408017223	KMSKS motif; other site
179408017224	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
179408017225	tRNA binding surface [nucleotide binding]; other site
179408017226	anticodon binding site; other site
179408017227	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
179408017228	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
179408017229	active site lid residues [active]
179408017230	substrate binding pocket [chemical binding]; other site
179408017231	catalytic residues [active]
179408017232	substrate-Mg2+ binding site; other site
179408017233	aspartate-rich region 1; other site
179408017234	aspartate-rich region 2; other site
179408017235	phytoene desaturase; Region: phytoene_desat; TIGR02731
179408017236	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
179408017237	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
179408017238	hypothetical protein; Provisional; Region: PRK06185
179408017239	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
179408017240	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
179408017241	molecular chaperone DnaK; Provisional; Region: PRK13410
179408017242	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
179408017243	nucleotide binding site [chemical binding]; other site
179408017244	NEF interaction site [polypeptide binding]; other site
179408017245	SBD interface [polypeptide binding]; other site
179408017246	four helix bundle protein; Region: TIGR02436
179408017247	hypothetical protein; Reviewed; Region: PRK12275
179408017248	chaperone protein DnaJ; Provisional; Region: PRK14299
179408017249	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
179408017250	HSP70 interaction site [polypeptide binding]; other site
179408017251	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
179408017252	substrate binding site [polypeptide binding]; other site
179408017253	dimer interface [polypeptide binding]; other site
179408017254	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
179408017255	G1 box; other site
179408017256	GTP/Mg2+ binding site [chemical binding]; other site
179408017257	G2 box; other site
179408017258	Switch I region; other site
179408017259	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
179408017260	G3 box; other site
179408017261	Switch II region; other site
179408017262	G4 box; other site
179408017263	KGK domain; Region: KGK; pfam08872
179408017264	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408017265	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408017266	active site
179408017267	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
179408017268	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
179408017269	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
179408017270	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408017271	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408017272	putative active site [active]
179408017273	heme pocket [chemical binding]; other site
179408017274	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408017275	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408017276	putative active site [active]
179408017277	heme pocket [chemical binding]; other site
179408017278	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408017279	putative active site [active]
179408017280	heme pocket [chemical binding]; other site
179408017281	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408017282	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408017283	PAS fold; Region: PAS_4; pfam08448
179408017284	PAS domain S-box; Region: sensory_box; TIGR00229
179408017285	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408017286	putative active site [active]
179408017287	heme pocket [chemical binding]; other site
179408017288	PAS fold; Region: PAS_4; pfam08448
179408017289	PAS domain S-box; Region: sensory_box; TIGR00229
179408017290	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408017291	putative active site [active]
179408017292	heme pocket [chemical binding]; other site
179408017293	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408017294	PAS fold; Region: PAS_3; pfam08447
179408017295	putative active site [active]
179408017296	heme pocket [chemical binding]; other site
179408017297	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
179408017298	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408017299	putative active site [active]
179408017300	heme pocket [chemical binding]; other site
179408017301	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408017302	dimer interface [polypeptide binding]; other site
179408017303	phosphorylation site [posttranslational modification]
179408017304	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408017305	ATP binding site [chemical binding]; other site
179408017306	Mg2+ binding site [ion binding]; other site
179408017307	G-X-G motif; other site
179408017308	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408017309	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408017310	active site
179408017311	phosphorylation site [posttranslational modification]
179408017312	intermolecular recognition site; other site
179408017313	dimerization interface [polypeptide binding]; other site
179408017314	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
179408017315	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408017316	dimerization interface [polypeptide binding]; other site
179408017317	PAS domain S-box; Region: sensory_box; TIGR00229
179408017318	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
179408017319	putative active site [active]
179408017320	heme pocket [chemical binding]; other site
179408017321	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408017322	PAS fold; Region: PAS_3; pfam08447
179408017323	putative active site [active]
179408017324	heme pocket [chemical binding]; other site
179408017325	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408017326	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408017327	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408017328	dimer interface [polypeptide binding]; other site
179408017329	phosphorylation site [posttranslational modification]
179408017330	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408017331	ATP binding site [chemical binding]; other site
179408017332	Mg2+ binding site [ion binding]; other site
179408017333	G-X-G motif; other site
179408017334	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408017335	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408017336	active site
179408017337	phosphorylation site [posttranslational modification]
179408017338	intermolecular recognition site; other site
179408017339	dimerization interface [polypeptide binding]; other site
179408017340	Response regulator receiver domain; Region: Response_reg; pfam00072
179408017341	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408017342	active site
179408017343	phosphorylation site [posttranslational modification]
179408017344	intermolecular recognition site; other site
179408017345	dimerization interface [polypeptide binding]; other site
179408017346	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408017347	dimer interface [polypeptide binding]; other site
179408017348	phosphorylation site [posttranslational modification]
179408017349	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408017350	ATP binding site [chemical binding]; other site
179408017351	Mg2+ binding site [ion binding]; other site
179408017352	G-X-G motif; other site
179408017353	GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450
179408017354	GIY-YIG motif/motif A; other site
179408017355	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
179408017356	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
179408017357	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
179408017358	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408017359	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017360	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017361	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017362	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017363	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017364	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017365	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017366	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017367	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408017368	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408017369	Probable transposase; Region: OrfB_IS605; pfam01385
179408017370	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
179408017371	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
179408017372	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408017373	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408017374	dimerization interface [polypeptide binding]; other site
179408017375	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408017376	ATP binding site [chemical binding]; other site
179408017377	Mg2+ binding site [ion binding]; other site
179408017378	G-X-G motif; other site
179408017379	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
179408017380	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
179408017381	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620
179408017382	FOG: CBS domain [General function prediction only]; Region: COG0517
179408017383	FOG: CBS domain [General function prediction only]; Region: COG0517
179408017384	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
179408017385	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408017386	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408017387	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408017388	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408017389	putative active site [active]
179408017390	heme pocket [chemical binding]; other site
179408017391	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408017392	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408017393	putative active site [active]
179408017394	heme pocket [chemical binding]; other site
179408017395	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408017396	putative active site [active]
179408017397	heme pocket [chemical binding]; other site
179408017398	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408017399	PAS fold; Region: PAS_3; pfam08447
179408017400	putative active site [active]
179408017401	heme pocket [chemical binding]; other site
179408017402	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408017403	PAS domain; Region: PAS_9; pfam13426
179408017404	putative active site [active]
179408017405	heme pocket [chemical binding]; other site
179408017406	PAS domain S-box; Region: sensory_box; TIGR00229
179408017407	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408017408	putative active site [active]
179408017409	heme pocket [chemical binding]; other site
179408017410	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408017411	PAS fold; Region: PAS_3; pfam08447
179408017412	putative active site [active]
179408017413	heme pocket [chemical binding]; other site
179408017414	PAS domain; Region: PAS_9; pfam13426
179408017415	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408017416	putative active site [active]
179408017417	heme pocket [chemical binding]; other site
179408017418	PAS domain S-box; Region: sensory_box; TIGR00229
179408017419	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408017420	putative active site [active]
179408017421	heme pocket [chemical binding]; other site
179408017422	PAS domain S-box; Region: sensory_box; TIGR00229
179408017423	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408017424	putative active site [active]
179408017425	heme pocket [chemical binding]; other site
179408017426	PAS fold; Region: PAS_4; pfam08448
179408017427	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
179408017428	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408017429	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408017430	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408017431	GAF domain; Region: GAF; pfam01590
179408017432	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408017433	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408017434	dimer interface [polypeptide binding]; other site
179408017435	phosphorylation site [posttranslational modification]
179408017436	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408017437	ATP binding site [chemical binding]; other site
179408017438	Mg2+ binding site [ion binding]; other site
179408017439	G-X-G motif; other site
179408017440	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408017441	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408017442	active site
179408017443	phosphorylation site [posttranslational modification]
179408017444	intermolecular recognition site; other site
179408017445	dimerization interface [polypeptide binding]; other site
179408017446	Response regulator receiver domain; Region: Response_reg; pfam00072
179408017447	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408017448	active site
179408017449	phosphorylation site [posttranslational modification]
179408017450	intermolecular recognition site; other site
179408017451	dimerization interface [polypeptide binding]; other site
179408017452	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408017453	ATP binding site [chemical binding]; other site
179408017454	Mg2+ binding site [ion binding]; other site
179408017455	G-X-G motif; other site
179408017456	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
179408017457	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
179408017458	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
179408017459	G1 box; other site
179408017460	GTP/Mg2+ binding site [chemical binding]; other site
179408017461	Switch I region; other site
179408017462	G2 box; other site
179408017463	Switch II region; other site
179408017464	G3 box; other site
179408017465	G4 box; other site
179408017466	G5 box; other site
179408017467	Domain of unknown function (DUF697); Region: DUF697; pfam05128
179408017468	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408017469	active site
179408017470	phosphorylation site [posttranslational modification]
179408017471	intermolecular recognition site; other site
179408017472	dimerization interface [polypeptide binding]; other site
179408017473	Heme NO binding associated; Region: HNOBA; pfam07701
179408017474	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
179408017475	cyclase homology domain; Region: CHD; cd07302
179408017476	nucleotidyl binding site; other site
179408017477	metal binding site [ion binding]; metal-binding site
179408017478	dimer interface [polypeptide binding]; other site
179408017479	phosphoribulokinase; Provisional; Region: PRK07429
179408017480	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
179408017481	active site
179408017482	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
179408017483	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
179408017484	Walker A/P-loop; other site
179408017485	ATP binding site [chemical binding]; other site
179408017486	Q-loop/lid; other site
179408017487	ABC transporter signature motif; other site
179408017488	Walker B; other site
179408017489	D-loop; other site
179408017490	H-loop/switch region; other site
179408017491	AAA ATPase domain; Region: AAA_16; pfam13191
179408017492	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408017493	TPR motif; other site
179408017494	TPR repeat; Region: TPR_11; pfam13414
179408017495	binding surface
179408017496	TPR repeat; Region: TPR_11; pfam13414
179408017497	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408017498	binding surface
179408017499	TPR motif; other site
179408017500	RDD family; Region: RDD; pfam06271
179408017501	AAA-like domain; Region: AAA_10; pfam12846
179408017502	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
179408017503	ATP binding site [chemical binding]; other site
179408017504	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
179408017505	MreB/Mbl protein; Region: MreB_Mbl; pfam06723
179408017506	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
179408017507	nucleotide binding site [chemical binding]; other site
179408017508	putative NEF/HSP70 interaction site [polypeptide binding]; other site
179408017509	SBD interface [polypeptide binding]; other site
179408017510	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408017511	putative active site [active]
179408017512	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
179408017513	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
179408017514	substrate binding site [chemical binding]; other site
179408017515	ATP binding site [chemical binding]; other site
179408017516	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
179408017517	Ecdysteroid kinase; Region: EcKinase; cl17738
179408017518	Predicted kinase [General function prediction only]; Region: COG0645
179408017519	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
179408017520	ATP-binding site [chemical binding]; other site
179408017521	Gluconate-6-phosphate binding site [chemical binding]; other site
179408017522	Uncharacterized conserved protein [Function unknown]; Region: COG1434
179408017523	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
179408017524	putative active site [active]
179408017525	Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941
179408017526	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
179408017527	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
179408017528	active site
179408017529	catalytic site [active]
179408017530	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
179408017531	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
179408017532	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
179408017533	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
179408017534	hypothetical protein; Provisional; Region: PRK06185
179408017535	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
179408017536	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408017537	putative active site [active]
179408017538	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
179408017539	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
179408017540	active site
179408017541	metal binding site [ion binding]; metal-binding site
179408017542	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
179408017543	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408017544	Coenzyme A binding pocket [chemical binding]; other site
179408017545	calcium/proton exchanger (cax); Region: cax; TIGR00378
179408017546	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
179408017547	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
179408017548	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408017549	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408017550	active site
179408017551	ATP binding site [chemical binding]; other site
179408017552	substrate binding site [chemical binding]; other site
179408017553	activation loop (A-loop); other site
179408017554	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408017555	structural tetrad; other site
179408017556	PQQ-like domain; Region: PQQ_2; pfam13360
179408017557	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
179408017558	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408017559	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
179408017560	active site
179408017561	intersubunit interactions; other site
179408017562	catalytic residue [active]
179408017563	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
179408017564	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
179408017565	quinone interaction residues [chemical binding]; other site
179408017566	active site
179408017567	catalytic residues [active]
179408017568	FMN binding site [chemical binding]; other site
179408017569	substrate binding site [chemical binding]; other site
179408017570	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408017571	GAF domain; Region: GAF; pfam01590
179408017572	GAF domain; Region: GAF; pfam01590
179408017573	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
179408017574	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
179408017575	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408017576	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408017577	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408017578	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408017579	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
179408017580	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408017581	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408017582	carotene isomerase; Region: carot_isom; TIGR02730
179408017583	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
179408017584	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
179408017585	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408017586	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017587	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017588	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017589	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408017590	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017591	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017592	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017593	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017594	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017595	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017596	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017597	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408017598	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408017599	active site
179408017600	ATP binding site [chemical binding]; other site
179408017601	substrate binding site [chemical binding]; other site
179408017602	activation loop (A-loop); other site
179408017603	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408017604	GAF domain; Region: GAF; pfam01590
179408017605	PAS fold; Region: PAS_4; pfam08448
179408017606	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408017607	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408017608	dimer interface [polypeptide binding]; other site
179408017609	phosphorylation site [posttranslational modification]
179408017610	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408017611	ATP binding site [chemical binding]; other site
179408017612	Mg2+ binding site [ion binding]; other site
179408017613	G-X-G motif; other site
179408017614	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
179408017615	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
179408017616	substrate binding site [chemical binding]; other site
179408017617	active site
179408017618	catalytic residues [active]
179408017619	heterodimer interface [polypeptide binding]; other site
179408017620	Protein of unknown function (DUF3007); Region: DUF3007; pfam11460
179408017621	NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716
179408017622	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408017623	dimerization interface [polypeptide binding]; other site
179408017624	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
179408017625	dimer interface [polypeptide binding]; other site
179408017626	phosphorylation site [posttranslational modification]
179408017627	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408017628	ATP binding site [chemical binding]; other site
179408017629	Mg2+ binding site [ion binding]; other site
179408017630	G-X-G motif; other site
179408017631	Radical SAM superfamily; Region: Radical_SAM; pfam04055
179408017632	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
179408017633	FeS/SAM binding site; other site
179408017634	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
179408017635	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
179408017636	alpha-gamma subunit interface [polypeptide binding]; other site
179408017637	beta-gamma subunit interface [polypeptide binding]; other site
179408017638	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
179408017639	gamma-beta subunit interface [polypeptide binding]; other site
179408017640	alpha-beta subunit interface [polypeptide binding]; other site
179408017641	Protein of unknown function (DUF563); Region: DUF563; pfam04577
179408017642	urease subunit alpha; Reviewed; Region: ureC; PRK13207
179408017643	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
179408017644	subunit interactions [polypeptide binding]; other site
179408017645	active site
179408017646	flap region; other site
179408017647	CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cd09740
179408017648	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
179408017649	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
179408017650	NAD synthetase; Provisional; Region: PRK13981
179408017651	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
179408017652	multimer interface [polypeptide binding]; other site
179408017653	active site
179408017654	catalytic triad [active]
179408017655	protein interface 1 [polypeptide binding]; other site
179408017656	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
179408017657	homodimer interface [polypeptide binding]; other site
179408017658	NAD binding pocket [chemical binding]; other site
179408017659	ATP binding pocket [chemical binding]; other site
179408017660	Mg binding site [ion binding]; other site
179408017661	active-site loop [active]
179408017662	Chorismate mutase type II; Region: CM_2; cl00693
179408017663	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
179408017664	nudix motif; other site
179408017665	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
179408017666	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
179408017667	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
179408017668	active site
179408017669	(T/H)XGH motif; other site
179408017670	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
179408017671	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
179408017672	active site
179408017673	NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794
179408017674	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
179408017675	NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794
179408017676	HlyD family secretion protein; Region: HlyD_3; pfam13437
179408017677	NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796
179408017678	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
179408017679	putative active site [active]
179408017680	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
179408017681	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408017682	Walker A/P-loop; other site
179408017683	ATP binding site [chemical binding]; other site
179408017684	Q-loop/lid; other site
179408017685	ABC transporter signature motif; other site
179408017686	Walker B; other site
179408017687	D-loop; other site
179408017688	H-loop/switch region; other site
179408017689	NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797
179408017690	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
179408017691	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408017692	Walker A/P-loop; other site
179408017693	ATP binding site [chemical binding]; other site
179408017694	Q-loop/lid; other site
179408017695	ABC transporter signature motif; other site
179408017696	Walker B; other site
179408017697	D-loop; other site
179408017698	H-loop/switch region; other site
179408017699	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
179408017700	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
179408017701	active site
179408017702	TDP-binding site; other site
179408017703	acceptor substrate-binding pocket; other site
179408017704	homodimer interface [polypeptide binding]; other site
179408017705	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
179408017706	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
179408017707	active site
179408017708	TDP-binding site; other site
179408017709	acceptor substrate-binding pocket; other site
179408017710	homodimer interface [polypeptide binding]; other site
179408017711	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408017712	active site
179408017713	ATP binding site [chemical binding]; other site
179408017714	substrate binding site [chemical binding]; other site
179408017715	Protein kinase; unclassified specificity; Region: STYKc; smart00221
179408017716	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
179408017717	substrate binding site [chemical binding]; other site
179408017718	activation loop (A-loop); other site
179408017719	activation loop (A-loop); other site
179408017720	AAA ATPase domain; Region: AAA_16; pfam13191
179408017721	Predicted ATPase [General function prediction only]; Region: COG3899
179408017722	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408017723	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408017724	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
179408017725	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408017726	putative active site [active]
179408017727	heme pocket [chemical binding]; other site
179408017728	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408017729	dimer interface [polypeptide binding]; other site
179408017730	phosphorylation site [posttranslational modification]
179408017731	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408017732	ATP binding site [chemical binding]; other site
179408017733	Mg2+ binding site [ion binding]; other site
179408017734	G-X-G motif; other site
179408017735	Response regulator receiver domain; Region: Response_reg; pfam00072
179408017736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408017737	active site
179408017738	phosphorylation site [posttranslational modification]
179408017739	intermolecular recognition site; other site
179408017740	dimerization interface [polypeptide binding]; other site
179408017741	Response regulator receiver domain; Region: Response_reg; pfam00072
179408017742	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408017743	active site
179408017744	phosphorylation site [posttranslational modification]
179408017745	intermolecular recognition site; other site
179408017746	dimerization interface [polypeptide binding]; other site
179408017747	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
179408017748	Histidine kinase; Region: HisKA_3; pfam07730
179408017749	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408017750	ATP binding site [chemical binding]; other site
179408017751	Mg2+ binding site [ion binding]; other site
179408017752	G-X-G motif; other site
179408017753	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
179408017754	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408017755	active site
179408017756	phosphorylation site [posttranslational modification]
179408017757	intermolecular recognition site; other site
179408017758	dimerization interface [polypeptide binding]; other site
179408017759	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
179408017760	DNA binding residues [nucleotide binding]
179408017761	dimerization interface [polypeptide binding]; other site
179408017762	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
179408017763	SPFH domain / Band 7 family; Region: Band_7; pfam01145
179408017764	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
179408017765	Ycf46; Provisional; Region: ycf46; CHL00195
179408017766	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
179408017767	H-loop/switch region; other site
179408017768	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408017769	Walker A motif; other site
179408017770	ATP binding site [chemical binding]; other site
179408017771	Walker B motif; other site
179408017772	arginine finger; other site
179408017773	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
179408017774	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
179408017775	Peptidase family M50; Region: Peptidase_M50; pfam02163
179408017776	active site
179408017777	putative substrate binding region [chemical binding]; other site
179408017778	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
179408017779	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
179408017780	Rrf2 family protein; Region: rrf2_super; TIGR00738
179408017781	Transcriptional regulator; Region: Rrf2; cl17282
179408017782	Uncharacterized conserved protein [Function unknown]; Region: COG3791
179408017783	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
179408017784	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
179408017785	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
179408017786	active site
179408017787	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
179408017788	Domain of unknown function DUF21; Region: DUF21; pfam01595
179408017789	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
179408017790	Transporter associated domain; Region: CorC_HlyC; smart01091
179408017791	TPR repeat; Region: TPR_11; pfam13414
179408017792	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408017793	binding surface
179408017794	TPR motif; other site
179408017795	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
179408017796	Ligand Binding Site [chemical binding]; other site
179408017797	cytosine deaminase-like protein; Validated; Region: PRK07583
179408017798	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
179408017799	active site
179408017800	hypothetical protein; Validated; Region: PRK07198
179408017801	GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471
179408017802	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
179408017803	dimerization interface [polypeptide binding]; other site
179408017804	active site
179408017805	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
179408017806	cyclase homology domain; Region: CHD; cd07302
179408017807	nucleotidyl binding site; other site
179408017808	metal binding site [ion binding]; metal-binding site
179408017809	dimer interface [polypeptide binding]; other site
179408017810	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
179408017811	cyclase homology domain; Region: CHD; cd07302
179408017812	nucleotidyl binding site; other site
179408017813	metal binding site [ion binding]; metal-binding site
179408017814	dimer interface [polypeptide binding]; other site
179408017815	Protein of unknown function (DUF1688); Region: DUF1688; pfam07958
179408017816	Domain of unknown function (DUF4360); Region: DUF4360; pfam14273
179408017817	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
179408017818	active site
179408017819	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
179408017820	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
179408017821	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
179408017822	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408017823	binding surface
179408017824	TPR motif; other site
179408017825	TPR repeat; Region: TPR_11; pfam13414
179408017826	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
179408017827	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
179408017828	active site
179408017829	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
179408017830	DinB superfamily; Region: DinB_2; pfam12867
179408017831	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
179408017832	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
179408017833	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
179408017834	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
179408017835	Walker A/P-loop; other site
179408017836	ATP binding site [chemical binding]; other site
179408017837	Q-loop/lid; other site
179408017838	ABC transporter signature motif; other site
179408017839	Walker B; other site
179408017840	D-loop; other site
179408017841	H-loop/switch region; other site
179408017842	Methyltransferase domain; Region: Methyltransf_23; pfam13489
179408017843	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408017844	S-adenosylmethionine binding site [chemical binding]; other site
179408017845	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408017846	putative active site [active]
179408017847	TPR repeat; Region: TPR_11; pfam13414
179408017848	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
179408017849	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
179408017850	putative ligand binding site [chemical binding]; other site
179408017851	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
179408017852	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
179408017853	cobalt transport protein CbiN; Provisional; Region: PRK02898
179408017854	cobalt transport protein CbiM; Validated; Region: PRK08319
179408017855	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
179408017856	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408017857	putative active site [active]
179408017858	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
179408017859	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
179408017860	RDD family; Region: RDD; pfam06271
179408017861	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408017862	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017863	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017864	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017865	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017866	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017867	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408017868	putative active site [active]
179408017869	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408017870	putative active site [active]
179408017871	deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556
179408017872	DNA photolyase; Region: DNA_photolyase; pfam00875
179408017873	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
179408017874	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
179408017875	dimer interface [polypeptide binding]; other site
179408017876	ADP-ribose binding site [chemical binding]; other site
179408017877	active site
179408017878	nudix motif; other site
179408017879	metal binding site [ion binding]; metal-binding site
179408017880	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
179408017881	catalytic center binding site [active]
179408017882	ATP binding site [chemical binding]; other site
179408017883	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
179408017884	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408017885	putative active site [active]
179408017886	hypothetical protein; Provisional; Region: PRK04194
179408017887	tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057
179408017888	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
179408017889	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
179408017890	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
179408017891	ATP binding site [chemical binding]; other site
179408017892	putative Mg++ binding site [ion binding]; other site
179408017893	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
179408017894	nucleotide binding region [chemical binding]; other site
179408017895	ATP-binding site [chemical binding]; other site
179408017896	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
179408017897	HRDC domain; Region: HRDC; pfam00570
179408017898	helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418
179408017899	dimerization interface [polypeptide binding]; other site
179408017900	putative Zn2+ binding site [ion binding]; other site
179408017901	putative DNA binding site [nucleotide binding]; other site
179408017902	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
179408017903	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
179408017904	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408017905	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
179408017906	Tetratricopeptide repeat; Region: TPR_16; pfam13432
179408017907	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408017908	binding surface
179408017909	TPR motif; other site
179408017910	TPR repeat; Region: TPR_11; pfam13414
179408017911	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408017912	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408017913	binding surface
179408017914	TPR motif; other site
179408017915	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
179408017916	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
179408017917	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
179408017918	HlyD family secretion protein; Region: HlyD_3; pfam13437
179408017919	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
179408017920	ligand binding site [chemical binding]; other site
179408017921	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
179408017922	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
179408017923	putative active site [active]
179408017924	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
179408017925	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
179408017926	Walker A/P-loop; other site
179408017927	ATP binding site [chemical binding]; other site
179408017928	Q-loop/lid; other site
179408017929	ABC transporter signature motif; other site
179408017930	Walker B; other site
179408017931	D-loop; other site
179408017932	H-loop/switch region; other site
179408017933	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
179408017934	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
179408017935	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
179408017936	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408017937	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408017938	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
179408017939	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
179408017940	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
179408017941	acyl-activating enzyme (AAE) consensus motif; other site
179408017942	putative AMP binding site [chemical binding]; other site
179408017943	putative active site [active]
179408017944	putative CoA binding site [chemical binding]; other site
179408017945	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
179408017946	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
179408017947	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
179408017948	E3 interaction surface; other site
179408017949	lipoyl attachment site [posttranslational modification]; other site
179408017950	e3 binding domain; Region: E3_binding; pfam02817
179408017951	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
179408017952	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
179408017953	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408017954	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408017955	active site
179408017956	ATP binding site [chemical binding]; other site
179408017957	substrate binding site [chemical binding]; other site
179408017958	activation loop (A-loop); other site
179408017959	AAA ATPase domain; Region: AAA_16; pfam13191
179408017960	Predicted ATPase [General function prediction only]; Region: COG3899
179408017961	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408017962	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408017963	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
179408017964	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
179408017965	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
179408017966	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
179408017967	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
179408017968	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408017969	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017970	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017971	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017972	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017973	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017974	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408017975	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
179408017976	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
179408017977	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
179408017978	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
179408017979	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
179408017980	Domain of unknown function (DUF1817); Region: DUF1817; pfam08847
179408017981	Response regulator receiver domain; Region: Response_reg; pfam00072
179408017982	Protein of unknown function (DUF3685); Region: DUF3685; pfam12452
179408017983	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
179408017984	metal binding site 2 [ion binding]; metal-binding site
179408017985	putative DNA binding helix; other site
179408017986	metal binding site 1 [ion binding]; metal-binding site
179408017987	dimer interface [polypeptide binding]; other site
179408017988	structural Zn2+ binding site [ion binding]; other site
179408017989	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408017990	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408017991	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
179408017992	putative active site [active]
179408017993	putative NTP binding site [chemical binding]; other site
179408017994	putative nucleic acid binding site [nucleotide binding]; other site
179408017995	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408017996	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408017997	active site
179408017998	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
179408017999	putative binding surface; other site
179408018000	active site
179408018001	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
179408018002	Uncharacterized conserved protein [Function unknown]; Region: COG2442
179408018003	ParB-like nuclease domain; Region: ParBc; cl02129
179408018004	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
179408018005	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
179408018006	dimerization interface [polypeptide binding]; other site
179408018007	DPS ferroxidase diiron center [ion binding]; other site
179408018008	ion pore; other site
179408018009	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
179408018010	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408018011	non-specific DNA binding site [nucleotide binding]; other site
179408018012	salt bridge; other site
179408018013	sequence-specific DNA binding site [nucleotide binding]; other site
179408018014	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
179408018015	dimer interface [polypeptide binding]; other site
179408018016	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
179408018017	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
179408018018	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
179408018019	anti sigma factor interaction site; other site
179408018020	regulatory phosphorylation site [posttranslational modification]; other site
179408018021	Response regulator receiver domain; Region: Response_reg; pfam00072
179408018022	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408018023	active site
179408018024	phosphorylation site [posttranslational modification]
179408018025	intermolecular recognition site; other site
179408018026	dimerization interface [polypeptide binding]; other site
179408018027	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
179408018028	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
179408018029	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
179408018030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
179408018031	ATP binding site [chemical binding]; other site
179408018032	Mg2+ binding site [ion binding]; other site
179408018033	G-X-G motif; other site
179408018034	Herpesvirus transcription activation factor (transactivator); Region: Herpes_TAF50; pfam03326
179408018035	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408018036	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
179408018037	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
179408018038	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
179408018039	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
179408018040	DNA binding residues [nucleotide binding]
179408018041	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
179408018042	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
179408018043	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
179408018044	active site
179408018045	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
179408018046	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
179408018047	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
179408018048	HSP70 interaction site [polypeptide binding]; other site
179408018049	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408018050	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018051	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018052	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
179408018053	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
179408018054	Protein of unknown function (DUF3120); Region: DUF3120; pfam11318
179408018055	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
179408018056	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
179408018057	C-terminal domain interface [polypeptide binding]; other site
179408018058	active site
179408018059	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
179408018060	active site
179408018061	N-terminal domain interface [polypeptide binding]; other site
179408018062	Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336
179408018063	PemK-like protein; Region: PemK; cl00995
179408018064	Protein of unknown function (DUF433); Region: DUF433; cl01030
179408018065	Uncharacterized conserved protein [Function unknown]; Region: COG2442
179408018066	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
179408018067	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
179408018068	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
179408018069	catalytic residue [active]
179408018070	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
179408018071	RNase_H superfamily; Region: RNase_H_2; pfam13482
179408018072	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
179408018073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
179408018074	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408018075	putative active site [active]
179408018076	Protein of unknown function, DUF393; Region: DUF393; pfam04134
179408018077	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
179408018078	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
179408018079	HIGH motif; other site
179408018080	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
179408018081	active site
179408018082	KMSKS motif; other site
179408018083	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
179408018084	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
179408018085	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
179408018086	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
179408018087	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
179408018088	aromatic arch; other site
179408018089	DCoH dimer interaction site [polypeptide binding]; other site
179408018090	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
179408018091	DCoH tetramer interaction site [polypeptide binding]; other site
179408018092	substrate binding site [chemical binding]; other site
179408018093	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
179408018094	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
179408018095	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
179408018096	ligand binding site [chemical binding]; other site
179408018097	flexible hinge region; other site
179408018098	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408018099	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408018100	binding surface
179408018101	TPR motif; other site
179408018102	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408018103	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
179408018104	binding surface
179408018105	TPR motif; other site
179408018106	CHAT domain; Region: CHAT; pfam12770
179408018107	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408018108	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408018109	Probable transposase; Region: OrfB_IS605; pfam01385
179408018110	acetylornithine aminotransferase; Provisional; Region: PRK02627
179408018111	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
179408018112	inhibitor-cofactor binding pocket; inhibition site
179408018113	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408018114	catalytic residue [active]
179408018115	ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional; Region: PLN00020
179408018116	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
179408018117	putative multimerization interface [polypeptide binding]; other site
179408018118	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
179408018119	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
179408018120	substrate binding site [chemical binding]; other site
179408018121	dimer interface [polypeptide binding]; other site
179408018122	ATP binding site [chemical binding]; other site
179408018123	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
179408018124	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408018125	active site
179408018126	phosphorylation site [posttranslational modification]
179408018127	intermolecular recognition site; other site
179408018128	dimerization interface [polypeptide binding]; other site
179408018129	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
179408018130	DNA binding site [nucleotide binding]
179408018131	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
179408018132	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
179408018133	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
179408018134	homodimer interface [polypeptide binding]; other site
179408018135	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408018136	catalytic residue [active]
179408018137	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
179408018138	active site
179408018139	ribulose/triose binding site [chemical binding]; other site
179408018140	phosphate binding site [ion binding]; other site
179408018141	substrate (anthranilate) binding pocket [chemical binding]; other site
179408018142	product (indole) binding pocket [chemical binding]; other site
179408018143	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
179408018144	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
179408018145	putative ligand binding site [chemical binding]; other site
179408018146	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408018147	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408018148	dimerization interface [polypeptide binding]; other site
179408018149	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408018150	dimer interface [polypeptide binding]; other site
179408018151	phosphorylation site [posttranslational modification]
179408018152	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408018153	ATP binding site [chemical binding]; other site
179408018154	Mg2+ binding site [ion binding]; other site
179408018155	G-X-G motif; other site
179408018156	Response regulator receiver domain; Region: Response_reg; pfam00072
179408018157	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408018158	active site
179408018159	phosphorylation site [posttranslational modification]
179408018160	intermolecular recognition site; other site
179408018161	dimerization interface [polypeptide binding]; other site
179408018162	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
179408018163	catalytic core [active]
179408018164	excinuclease ABC subunit B; Provisional; Region: PRK05298
179408018165	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
179408018166	ATP binding site [chemical binding]; other site
179408018167	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
179408018168	nucleotide binding region [chemical binding]; other site
179408018169	ATP-binding site [chemical binding]; other site
179408018170	Ultra-violet resistance protein B; Region: UvrB; pfam12344
179408018171	Protein of unknown function (DUF433); Region: DUF433; pfam04255
179408018172	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
179408018173	Protein of unknown function (DUF433); Region: DUF433; pfam04255
179408018174	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
179408018175	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
179408018176	active site
179408018177	catalytic tetrad [active]
179408018178	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
179408018179	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
179408018180	inhibitor-cofactor binding pocket; inhibition site
179408018181	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408018182	catalytic residue [active]
179408018183	cyanoexosortase B; Region: cyanoexo_CrtB; TIGR04156
179408018184	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
179408018185	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
179408018186	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
179408018187	SLBB domain; Region: SLBB; pfam10531
179408018188	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
179408018189	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
179408018190	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
179408018191	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
179408018192	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
179408018193	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
179408018194	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408018195	non-specific DNA binding site [nucleotide binding]; other site
179408018196	salt bridge; other site
179408018197	sequence-specific DNA binding site [nucleotide binding]; other site
179408018198	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
179408018199	AAA ATPase domain; Region: AAA_16; pfam13191
179408018200	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
179408018201	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
179408018202	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
179408018203	Calx-beta domain; Region: Calx-beta; cl02522
179408018204	Calx-beta domain; Region: Calx-beta; cl02522
179408018205	Calx-beta domain; Region: Calx-beta; cl02522
179408018206	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
179408018207	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
179408018208	vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461
179408018209	metal ion-dependent adhesion site (MIDAS); other site
179408018210	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
179408018211	NAD(P) binding site [chemical binding]; other site
179408018212	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
179408018213	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
179408018214	active site
179408018215	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
179408018216	Leucine-rich repeats; other site
179408018217	Substrate binding site [chemical binding]; other site
179408018218	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
179408018219	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
179408018220	substrate binding site [chemical binding]; other site
179408018221	hexamer interface [polypeptide binding]; other site
179408018222	metal binding site [ion binding]; metal-binding site
179408018223	Transcriptional regulator [Transcription]; Region: LytR; COG1316
179408018224	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
179408018225	Predicted membrane protein [Function unknown]; Region: COG2149
179408018226	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408018227	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408018228	dimerization interface [polypeptide binding]; other site
179408018229	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408018230	dimer interface [polypeptide binding]; other site
179408018231	phosphorylation site [posttranslational modification]
179408018232	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408018233	ATP binding site [chemical binding]; other site
179408018234	Mg2+ binding site [ion binding]; other site
179408018235	G-X-G motif; other site
179408018236	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
179408018237	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408018238	active site
179408018239	phosphorylation site [posttranslational modification]
179408018240	intermolecular recognition site; other site
179408018241	dimerization interface [polypeptide binding]; other site
179408018242	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
179408018243	DNA binding site [nucleotide binding]
179408018244	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
179408018245	hydrolase, alpha/beta fold family protein; Region: PLN02824
179408018246	agmatinase; Region: agmatinase; TIGR01230
179408018247	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
179408018248	putative active site [active]
179408018249	Mn binding site [ion binding]; other site
179408018250	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
179408018251	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
179408018252	putative catalytic residue [active]
179408018253	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
179408018254	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
179408018255	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
179408018256	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
179408018257	dimer interface [polypeptide binding]; other site
179408018258	conserved gate region; other site
179408018259	putative PBP binding loops; other site
179408018260	ABC-ATPase subunit interface; other site
179408018261	ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297
179408018262	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
179408018263	Walker A/P-loop; other site
179408018264	ATP binding site [chemical binding]; other site
179408018265	Q-loop/lid; other site
179408018266	ABC transporter signature motif; other site
179408018267	Walker B; other site
179408018268	D-loop; other site
179408018269	H-loop/switch region; other site
179408018270	methionine sulfoxide reductase B; Provisional; Region: PRK00222
179408018271	SelR domain; Region: SelR; pfam01641
179408018272	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
179408018273	putative nucleotide binding site [chemical binding]; other site
179408018274	uridine monophosphate binding site [chemical binding]; other site
179408018275	homohexameric interface [polypeptide binding]; other site
179408018276	ribosome recycling factor; Reviewed; Region: frr; PRK00083
179408018277	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
179408018278	hinge region; other site
179408018279	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
179408018280	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408018281	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408018282	Phytochrome region; Region: PHY; pfam00360
179408018283	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408018284	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408018285	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408018286	dimer interface [polypeptide binding]; other site
179408018287	phosphorylation site [posttranslational modification]
179408018288	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408018289	ATP binding site [chemical binding]; other site
179408018290	G-X-G motif; other site
179408018291	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408018292	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018293	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018294	TPR repeat; Region: TPR_11; pfam13414
179408018295	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408018296	binding surface
179408018297	TPR motif; other site
179408018298	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018299	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408018300	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018301	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018302	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408018303	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018304	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018305	Homeodomain-like domain; Region: HTH_23; pfam13384
179408018306	Winged helix-turn helix; Region: HTH_29; pfam13551
179408018307	Homeodomain-like domain; Region: HTH_32; pfam13565
179408018308	Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158
179408018309	putative homodimer interface [polypeptide binding]; other site
179408018310	putative homotetramer interface [polypeptide binding]; other site
179408018311	putative metal binding site [ion binding]; other site
179408018312	putative homodimer-homodimer interface [polypeptide binding]; other site
179408018313	putative allosteric switch controlling residues; other site
179408018314	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
179408018315	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
179408018316	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
179408018317	protein binding site [polypeptide binding]; other site
179408018318	calmodulin; Provisional; Region: PTZ00184
179408018319	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
179408018320	Ca2+ binding site [ion binding]; other site
179408018321	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
179408018322	Ca2+ binding site [ion binding]; other site
179408018323	Erv1 / Alr family; Region: Evr1_Alr; cl02107
179408018324	TPR repeat; Region: TPR_11; pfam13414
179408018325	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408018326	binding surface
179408018327	TPR motif; other site
179408018328	TPR repeat; Region: TPR_11; pfam13414
179408018329	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408018330	binding surface
179408018331	TPR motif; other site
179408018332	TPR repeat; Region: TPR_11; pfam13414
179408018333	TPR repeat; Region: TPR_11; pfam13414
179408018334	TPR repeat; Region: TPR_11; pfam13414
179408018335	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408018336	binding surface
179408018337	TPR motif; other site
179408018338	TPR repeat; Region: TPR_11; pfam13414
179408018339	TPR repeat; Region: TPR_11; pfam13414
179408018340	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408018341	binding surface
179408018342	TPR motif; other site
179408018343	TPR repeat; Region: TPR_11; pfam13414
179408018344	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
179408018345	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
179408018346	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
179408018347	C-terminal domain interface [polypeptide binding]; other site
179408018348	GSH binding site (G-site) [chemical binding]; other site
179408018349	dimer interface [polypeptide binding]; other site
179408018350	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
179408018351	substrate binding pocket (H-site) [chemical binding]; other site
179408018352	N-terminal domain interface [polypeptide binding]; other site
179408018353	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
179408018354	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408018355	binding surface
179408018356	TPR motif; other site
179408018357	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408018358	binding surface
179408018359	TPR motif; other site
179408018360	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408018361	dimer interface [polypeptide binding]; other site
179408018362	phosphorylation site [posttranslational modification]
179408018363	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
179408018364	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408018365	ATP binding site [chemical binding]; other site
179408018366	Mg2+ binding site [ion binding]; other site
179408018367	G-X-G motif; other site
179408018368	Response regulator receiver domain; Region: Response_reg; pfam00072
179408018369	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408018370	active site
179408018371	phosphorylation site [posttranslational modification]
179408018372	intermolecular recognition site; other site
179408018373	dimerization interface [polypeptide binding]; other site
179408018374	KaiA domain; Region: KaiA; pfam07688
179408018375	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
179408018376	tetramer interface [polypeptide binding]; other site
179408018377	dimer interface [polypeptide binding]; other site
179408018378	circadian clock protein KaiC; Region: circ_KaiC; TIGR02655
179408018379	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
179408018380	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
179408018381	Walker A motif; other site
179408018382	Walker A motif; other site
179408018383	ATP binding site [chemical binding]; other site
179408018384	Walker B motif; other site
179408018385	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
179408018386	ATP binding site [chemical binding]; other site
179408018387	Walker B motif; other site
179408018388	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
179408018389	PAS fold; Region: PAS; pfam00989
179408018390	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408018391	putative active site [active]
179408018392	heme pocket [chemical binding]; other site
179408018393	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408018394	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408018395	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
179408018396	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
179408018397	metal binding site [ion binding]; metal-binding site
179408018398	active site
179408018399	I-site; other site
179408018400	Cache domain; Region: Cache_1; pfam02743
179408018401	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408018402	dimerization interface [polypeptide binding]; other site
179408018403	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408018404	dimer interface [polypeptide binding]; other site
179408018405	phosphorylation site [posttranslational modification]
179408018406	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408018407	ATP binding site [chemical binding]; other site
179408018408	Mg2+ binding site [ion binding]; other site
179408018409	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408018410	G-X-G motif; other site
179408018411	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408018412	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408018413	active site
179408018414	phosphorylation site [posttranslational modification]
179408018415	intermolecular recognition site; other site
179408018416	dimerization interface [polypeptide binding]; other site
179408018417	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408018418	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408018419	active site
179408018420	phosphorylation site [posttranslational modification]
179408018421	intermolecular recognition site; other site
179408018422	dimerization interface [polypeptide binding]; other site
179408018423	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408018424	dimer interface [polypeptide binding]; other site
179408018425	phosphorylation site [posttranslational modification]
179408018426	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408018427	ATP binding site [chemical binding]; other site
179408018428	Mg2+ binding site [ion binding]; other site
179408018429	G-X-G motif; other site
179408018430	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408018431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408018432	active site
179408018433	phosphorylation site [posttranslational modification]
179408018434	intermolecular recognition site; other site
179408018435	dimerization interface [polypeptide binding]; other site
179408018436	Response regulator receiver domain; Region: Response_reg; pfam00072
179408018437	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408018438	active site
179408018439	phosphorylation site [posttranslational modification]
179408018440	intermolecular recognition site; other site
179408018441	dimerization interface [polypeptide binding]; other site
179408018442	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408018443	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408018444	putative active site [active]
179408018445	heme pocket [chemical binding]; other site
179408018446	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408018447	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408018448	putative active site [active]
179408018449	heme pocket [chemical binding]; other site
179408018450	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408018451	putative active site [active]
179408018452	heme pocket [chemical binding]; other site
179408018453	cyclase homology domain; Region: CHD; cd07302
179408018454	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
179408018455	nucleotidyl binding site; other site
179408018456	metal binding site [ion binding]; metal-binding site
179408018457	dimer interface [polypeptide binding]; other site
179408018458	Response regulator receiver domain; Region: Response_reg; pfam00072
179408018459	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408018460	active site
179408018461	phosphorylation site [posttranslational modification]
179408018462	intermolecular recognition site; other site
179408018463	dimerization interface [polypeptide binding]; other site
179408018464	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408018465	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408018466	phosphorylation site [posttranslational modification]
179408018467	dimer interface [polypeptide binding]; other site
179408018468	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408018469	ATP binding site [chemical binding]; other site
179408018470	Mg2+ binding site [ion binding]; other site
179408018471	G-X-G motif; other site
179408018472	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408018473	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
179408018474	active site
179408018475	phosphorylation site [posttranslational modification]
179408018476	intermolecular recognition site; other site
179408018477	dimerization interface [polypeptide binding]; other site
179408018478	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
179408018479	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408018480	putative active site [active]
179408018481	heme pocket [chemical binding]; other site
179408018482	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408018483	dimer interface [polypeptide binding]; other site
179408018484	phosphorylation site [posttranslational modification]
179408018485	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408018486	ATP binding site [chemical binding]; other site
179408018487	Mg2+ binding site [ion binding]; other site
179408018488	G-X-G motif; other site
179408018489	Response regulator receiver domain; Region: Response_reg; pfam00072
179408018490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408018491	active site
179408018492	phosphorylation site [posttranslational modification]
179408018493	intermolecular recognition site; other site
179408018494	dimerization interface [polypeptide binding]; other site
179408018495	PAS domain S-box; Region: sensory_box; TIGR00229
179408018496	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408018497	putative active site [active]
179408018498	heme pocket [chemical binding]; other site
179408018499	PAS domain S-box; Region: sensory_box; TIGR00229
179408018500	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408018501	putative active site [active]
179408018502	heme pocket [chemical binding]; other site
179408018503	PAS domain S-box; Region: sensory_box; TIGR00229
179408018504	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408018505	putative active site [active]
179408018506	heme pocket [chemical binding]; other site
179408018507	PAS domain S-box; Region: sensory_box; TIGR00229
179408018508	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408018509	putative active site [active]
179408018510	heme pocket [chemical binding]; other site
179408018511	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408018512	dimer interface [polypeptide binding]; other site
179408018513	phosphorylation site [posttranslational modification]
179408018514	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408018515	ATP binding site [chemical binding]; other site
179408018516	Mg2+ binding site [ion binding]; other site
179408018517	G-X-G motif; other site
179408018518	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
179408018519	transketolase; Region: PLN02790
179408018520	TPP-binding site [chemical binding]; other site
179408018521	dimer interface [polypeptide binding]; other site
179408018522	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
179408018523	PYR/PP interface [polypeptide binding]; other site
179408018524	dimer interface [polypeptide binding]; other site
179408018525	TPP binding site [chemical binding]; other site
179408018526	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
179408018527	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
179408018528	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
179408018529	dimer interface [polypeptide binding]; other site
179408018530	putative anticodon binding site; other site
179408018531	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
179408018532	motif 1; other site
179408018533	active site
179408018534	motif 2; other site
179408018535	motif 3; other site
179408018536	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
179408018537	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
179408018538	putative metal binding site [ion binding]; other site
179408018539	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
179408018540	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
179408018541	putative metal binding site [ion binding]; other site
179408018542	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
179408018543	metal ion-dependent adhesion site (MIDAS); other site
179408018544	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
179408018545	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
179408018546	putative metal binding site [ion binding]; other site
179408018547	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
179408018548	active site
179408018549	AAA domain; Region: AAA_33; pfam13671
179408018550	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
179408018551	active site
179408018552	catalytic residues [active]
179408018553	metal binding site [ion binding]; metal-binding site
179408018554	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
179408018555	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
179408018556	protein binding site [polypeptide binding]; other site
179408018557	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
179408018558	Herpes DNA replication accessory factor; Region: Herpes_DNAp_acc; pfam04929
179408018559	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
179408018560	four helix bundle protein; Region: TIGR02436
179408018561	AAA-like domain; Region: AAA_10; pfam12846
179408018562	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408018563	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408018564	Probable transposase; Region: OrfB_IS605; pfam01385
179408018565	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408018566	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
179408018567	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
179408018568	P-loop; other site
179408018569	Magnesium ion binding site [ion binding]; other site
179408018570	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
179408018571	Magnesium ion binding site [ion binding]; other site
179408018572	ParB-like nuclease domain; Region: ParBc; pfam02195
179408018573	XisI protein; Region: XisI; pfam08869
179408018574	XisH protein; Region: XisH; pfam08814
179408018575	HipA N-terminal domain; Region: Couple_hipA; cl11853
179408018576	The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910
179408018577	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408018578	putative active site [active]
179408018579	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408018580	non-specific DNA binding site [nucleotide binding]; other site
179408018581	salt bridge; other site
179408018582	sequence-specific DNA binding site [nucleotide binding]; other site
179408018583	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
179408018584	replicative DNA helicase; Region: DnaB; TIGR00665
179408018585	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
179408018586	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
179408018587	Walker A motif; other site
179408018588	ATP binding site [chemical binding]; other site
179408018589	Walker B motif; other site
179408018590	DNA binding loops [nucleotide binding]
179408018591	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
179408018592	metal ion-dependent adhesion site (MIDAS); other site
179408018593	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
179408018594	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
179408018595	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622
179408018596	RHS Repeat; Region: RHS_repeat; pfam05593
179408018597	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
179408018598	RHS Repeat; Region: RHS_repeat; pfam05593
179408018599	RHS Repeat; Region: RHS_repeat; pfam05593
179408018600	RHS Repeat; Region: RHS_repeat; pfam05593
179408018601	RHS Repeat; Region: RHS_repeat; pfam05593
179408018602	RHS Repeat; Region: RHS_repeat; pfam05593
179408018603	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
179408018604	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
179408018605	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
179408018606	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
179408018607	RHS Repeat; Region: RHS_repeat; pfam05593
179408018608	RHS Repeat; Region: RHS_repeat; pfam05593
179408018609	RHS Repeat; Region: RHS_repeat; pfam05593
179408018610	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
179408018611	RHS Repeat; Region: RHS_repeat; pfam05593
179408018612	RHS Repeat; Region: RHS_repeat; pfam05593
179408018613	RHS Repeat; Region: RHS_repeat; cl11982
179408018614	RHS Repeat; Region: RHS_repeat; pfam05593
179408018615	RHS Repeat; Region: RHS_repeat; pfam05593
179408018616	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
179408018617	Phosphopantetheine attachment site; Region: PP-binding; cl09936
179408018618	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
179408018619	protein-splicing catalytic site; other site
179408018620	thioester formation/cholesterol transfer; other site
179408018621	Pretoxin HINT domain; Region: PT-HINT; pfam07591
179408018622	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
179408018623	Transposase [DNA replication, recombination, and repair]; Region: COG5421
179408018624	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
179408018625	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
179408018626	AAA domain; Region: AAA_30; pfam13604
179408018627	AAA domain; Region: AAA_11; pfam13086
179408018628	Family description; Region: UvrD_C_2; pfam13538
179408018629	DNA polymerase III subunit beta; Validated; Region: PRK05643
179408018630	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
179408018631	putative DNA binding surface [nucleotide binding]; other site
179408018632	dimer interface [polypeptide binding]; other site
179408018633	beta-clamp/clamp loader binding surface; other site
179408018634	beta-clamp/translesion DNA polymerase binding surface; other site
179408018635	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
179408018636	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408018637	Walker A motif; other site
179408018638	ATP binding site [chemical binding]; other site
179408018639	Walker B motif; other site
179408018640	arginine finger; other site
179408018641	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
179408018642	DNA polymerase III subunit delta; Validated; Region: PRK07452
179408018643	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
179408018644	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
179408018645	non-specific DNA binding site [nucleotide binding]; other site
179408018646	salt bridge; other site
179408018647	sequence-specific DNA binding site [nucleotide binding]; other site
179408018648	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
179408018649	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
179408018650	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
179408018651	ATP binding site [chemical binding]; other site
179408018652	putative Mg++ binding site [ion binding]; other site
179408018653	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
179408018654	nucleotide binding region [chemical binding]; other site
179408018655	ATP-binding site [chemical binding]; other site
179408018656	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
179408018657	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408018658	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408018659	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
179408018660	putative active site [active]
179408018661	putative NTP binding site [chemical binding]; other site
179408018662	putative nucleic acid binding site [nucleotide binding]; other site
179408018663	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408018664	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408018665	active site
179408018666	RRXRR protein; Region: RRXRR; pfam14239
179408018667	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408018668	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408018669	active site
179408018670	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
179408018671	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408018672	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
179408018673	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408018674	putative active site [active]
179408018675	putative NTP binding site [chemical binding]; other site
179408018676	putative nucleic acid binding site [nucleotide binding]; other site
179408018677	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408018678	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408018679	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408018680	active site
179408018681	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408018682	Winged helix-turn helix; Region: HTH_29; pfam13551
179408018683	non-specific DNA binding site [nucleotide binding]; other site
179408018684	salt bridge; other site
179408018685	sequence-specific DNA binding site [nucleotide binding]; other site
179408018686	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408018687	Probable transposase; Region: OrfB_IS605; pfam01385
179408018688	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408018689	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
179408018690	DDE superfamily endonuclease; Region: DDE_3; pfam13358
179408018691	Response regulator receiver domain; Region: Response_reg; pfam00072
179408018692	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408018693	active site
179408018694	phosphorylation site [posttranslational modification]
179408018695	intermolecular recognition site; other site
179408018696	dimerization interface [polypeptide binding]; other site
179408018697	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408018698	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408018699	ATP binding site [chemical binding]; other site
179408018700	Mg2+ binding site [ion binding]; other site
179408018701	G-X-G motif; other site
179408018702	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
179408018703	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
179408018704	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
179408018705	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408018706	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408018707	Probable transposase; Region: OrfB_IS605; pfam01385
179408018708	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408018709	bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975
179408018710	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
179408018711	active site
179408018712	catalytic site [active]
179408018713	substrate binding site [chemical binding]; other site
179408018714	Phylum Aquificae Pol A is different from Escherichia coli  Pol A by three signature sequences; Region: DNA_pol_A_Aquificae_like; cd08639
179408018715	active site
179408018716	DNA binding site [nucleotide binding]
179408018717	catalytic site [active]
179408018718	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
179408018719	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
179408018720	S-layer homology domain; Region: SLH; pfam00395
179408018721	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
179408018722	Isochorismatase family; Region: Isochorismatase; pfam00857
179408018723	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
179408018724	catalytic triad [active]
179408018725	dimer interface [polypeptide binding]; other site
179408018726	conserved cis-peptide bond; other site
179408018727	Isochorismatase family; Region: Isochorismatase; pfam00857
179408018728	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
179408018729	catalytic triad [active]
179408018730	dimer interface [polypeptide binding]; other site
179408018731	conserved cis-peptide bond; other site
179408018732	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408018733	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408018734	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
179408018735	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408018736	active site
179408018737	ATP binding site [chemical binding]; other site
179408018738	substrate binding site [chemical binding]; other site
179408018739	activation loop (A-loop); other site
179408018740	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
179408018741	AAA ATPase domain; Region: AAA_16; pfam13191
179408018742	Predicted ATPase [General function prediction only]; Region: COG3899
179408018743	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
179408018744	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
179408018745	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408018746	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
179408018747	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408018748	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
179408018749	putative active site [active]
179408018750	heme pocket [chemical binding]; other site
179408018751	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408018752	putative active site [active]
179408018753	heme pocket [chemical binding]; other site
179408018754	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408018755	PAS fold; Region: PAS_3; pfam08447
179408018756	putative active site [active]
179408018757	heme pocket [chemical binding]; other site
179408018758	PAS fold; Region: PAS_4; pfam08448
179408018759	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
179408018760	putative active site [active]
179408018761	heme pocket [chemical binding]; other site
179408018762	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
179408018763	Histidine kinase; Region: HisKA_3; pfam07730
179408018764	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408018765	ATP binding site [chemical binding]; other site
179408018766	Mg2+ binding site [ion binding]; other site
179408018767	G-X-G motif; other site
179408018768	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
179408018769	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408018770	active site
179408018771	phosphorylation site [posttranslational modification]
179408018772	intermolecular recognition site; other site
179408018773	dimerization interface [polypeptide binding]; other site
179408018774	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
179408018775	dimerization interface [polypeptide binding]; other site
179408018776	DNA binding residues [nucleotide binding]
179408018777	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
179408018778	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
179408018779	catalytic residues [active]
179408018780	short chain dehydrogenase; Provisional; Region: PRK06172
179408018781	classical (c) SDRs; Region: SDR_c; cd05233
179408018782	NAD(P) binding site [chemical binding]; other site
179408018783	active site
179408018784	Pirin-related protein [General function prediction only]; Region: COG1741
179408018785	Pirin; Region: Pirin; pfam02678
179408018786	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
179408018787	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
179408018788	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
179408018789	short chain dehydrogenase; Provisional; Region: PRK06172
179408018790	classical (c) SDRs; Region: SDR_c; cd05233
179408018791	NAD(P) binding site [chemical binding]; other site
179408018792	active site
179408018793	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
179408018794	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
179408018795	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
179408018796	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
179408018797	putative NAD(P) binding site [chemical binding]; other site
179408018798	SnoaL-like domain; Region: SnoaL_2; pfam12680
179408018799	short chain dehydrogenase; Provisional; Region: PRK06172
179408018800	classical (c) SDRs; Region: SDR_c; cd05233
179408018801	NAD(P) binding site [chemical binding]; other site
179408018802	active site
179408018803	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
179408018804	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
179408018805	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
179408018806	chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465
179408018807	active site
179408018808	Lipocalin-like domain; Region: Lipocalin_5; pfam13924
179408018809	Predicted membrane protein [Function unknown]; Region: COG3374
179408018810	Protein of unknown function (DUF981); Region: DUF981; pfam06168
179408018811	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
179408018812	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
179408018813	active site
179408018814	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
179408018815	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
179408018816	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
179408018817	Pirin-related protein [General function prediction only]; Region: COG1741
179408018818	Pirin; Region: Pirin; pfam02678
179408018819	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
179408018820	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
179408018821	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
179408018822	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
179408018823	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_like_4; cd06152
179408018824	homotrimer interaction site [polypeptide binding]; other site
179408018825	putative active site [active]
179408018826	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
179408018827	Transposase [DNA replication, recombination, and repair]; Region: COG5421
179408018828	ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004
179408018829	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622
179408018830	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
179408018831	Homeodomain-like domain; Region: HTH_23; cl17451
179408018832	DDE superfamily endonuclease; Region: DDE_3; pfam13358
179408018833	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
179408018834	RRXRR protein; Region: RRXRR; pfam14239
179408018835	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408018836	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408018837	active site
179408018838	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408018839	putative active site [active]
179408018840	Ribbon-helix-helix domain; Region: RHH_4; cl01775
179408018841	HEPN domain; Region: HEPN; cl00824
179408018842	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
179408018843	active site
179408018844	NTP binding site [chemical binding]; other site
179408018845	metal binding triad [ion binding]; metal-binding site
179408018846	antibiotic binding site [chemical binding]; other site
179408018847	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408018848	Probable transposase; Region: OrfB_IS605; pfam01385
179408018849	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408018850	DDE superfamily endonuclease; Region: DDE_3; pfam13358
179408018851	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
179408018852	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408018853	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408018854	Probable transposase; Region: OrfB_IS605; pfam01385
179408018855	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
179408018856	DDE superfamily endonuclease; Region: DDE_3; pfam13358
179408018857	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
179408018858	Mg binding site [ion binding]; other site
179408018859	nucleotide binding site [chemical binding]; other site
179408018860	putative protofilament interface [polypeptide binding]; other site
179408018861	Domain of unknown function (DUF3846); Region: DUF3846; pfam12957
179408018862	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
179408018863	HNH endonuclease; Region: HNH_3; pfam13392
179408018864	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408018865	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408018866	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
179408018867	putative active site [active]
179408018868	putative NTP binding site [chemical binding]; other site
179408018869	putative nucleic acid binding site [nucleotide binding]; other site
179408018870	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408018871	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408018872	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408018873	active site
179408018874	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408018875	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408018876	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
179408018877	putative active site [active]
179408018878	putative NTP binding site [chemical binding]; other site
179408018879	putative nucleic acid binding site [nucleotide binding]; other site
179408018880	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408018881	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408018882	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408018883	active site
179408018884	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
179408018885	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
179408018886	putative dimer interface [polypeptide binding]; other site
179408018887	Protein kinase domain; Region: Pkinase; pfam00069
179408018888	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408018889	active site
179408018890	ATP binding site [chemical binding]; other site
179408018891	substrate binding site [chemical binding]; other site
179408018892	activation loop (A-loop); other site
179408018893	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
179408018894	active site
179408018895	catalytic residues [active]
179408018896	DNA binding site [nucleotide binding]
179408018897	Int/Topo IB signature motif; other site
179408018898	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
179408018899	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408018900	active site
179408018901	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
179408018902	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
179408018903	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
179408018904	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
179408018905	active site
179408018906	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408018907	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
179408018908	structural tetrad; other site
179408018909	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
179408018910	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
179408018911	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
179408018912	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
179408018913	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
179408018914	KWG Leptospira; Region: KWG; pfam07656
179408018915	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
179408018916	Cadherin repeat-like domain; Region: CA_like; cl15786
179408018917	RHS Repeat; Region: RHS_repeat; cl11982
179408018918	Family description; Region: VCBS; pfam13517
179408018919	FG-GAP repeat; Region: FG-GAP; pfam01839
179408018920	Family description; Region: VCBS; pfam13517
179408018921	Family description; Region: VCBS; pfam13517
179408018922	Family description; Region: VCBS; pfam13517
179408018923	RHS Repeat; Region: RHS_repeat; pfam05593
179408018924	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
179408018925	RHS Repeat; Region: RHS_repeat; pfam05593
179408018926	RHS Repeat; Region: RHS_repeat; pfam05593
179408018927	RHS Repeat; Region: RHS_repeat; pfam05593
179408018928	RHS Repeat; Region: RHS_repeat; pfam05593
179408018929	RHS Repeat; Region: RHS_repeat; pfam05593
179408018930	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
179408018931	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
179408018932	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
179408018933	Protein of unknown function (DUF2778); Region: DUF2778; pfam10908
179408018934	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
179408018935	active site
179408018936	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
179408018937	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
179408018938	TPR motif; other site
179408018939	Tetratricopeptide repeat; Region: TPR_12; pfam13424
179408018940	binding surface
179408018941	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
179408018942	XisH protein; Region: XisH; pfam08814
179408018943	XisI protein; Region: XisI; pfam08869
179408018944	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408018945	putative active site [active]
179408018946	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
179408018947	D5 N terminal like; Region: D5_N; pfam08706
179408018948	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
179408018949	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
179408018950	Uncharacterized conserved protein [Function unknown]; Region: COG3391
179408018951	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408018952	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
179408018953	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408018954	putative active site [active]
179408018955	putative NTP binding site [chemical binding]; other site
179408018956	putative nucleic acid binding site [nucleotide binding]; other site
179408018957	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408018958	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408018959	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408018960	active site
179408018961	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408018962	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018963	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018964	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018965	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018966	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018967	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018968	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018969	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408018970	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018971	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018972	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018973	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
179408018974	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
179408018975	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
179408018976	active site
179408018977	substrate binding site [chemical binding]; other site
179408018978	Mg2+ binding site [ion binding]; other site
179408018979	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018980	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408018981	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018982	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408018983	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
179408018984	Uncharacterized conserved protein [Function unknown]; Region: COG3391
179408018985	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
179408018986	binding surface
179408018987	TPR motif; other site
179408018988	TPR repeat; Region: TPR_11; pfam13414
179408018989	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
179408018990	binding surface
179408018991	TPR motif; other site
179408018992	RHS Repeat; Region: RHS_repeat; cl11982
179408018993	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
179408018994	HEAT repeats; Region: HEAT_2; pfam13646
179408018995	HEAT repeats; Region: HEAT_2; pfam13646
179408018996	Putative Ig domain; Region: He_PIG; pfam05345
179408018997	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
179408018998	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
179408018999	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408019000	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
179408019001	sequence-specific DNA binding site [nucleotide binding]; other site
179408019002	salt bridge; other site
179408019003	Double zinc ribbon; Region: DZR; pfam12773
179408019004	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
179408019005	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
179408019006	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
179408019007	active site
179408019008	catalytic residues [active]
179408019009	DNA binding site [nucleotide binding]
179408019010	Int/Topo IB signature motif; other site
179408019011	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
179408019012	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
179408019013	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
179408019014	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
179408019015	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
179408019016	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
179408019017	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
179408019018	RHS Repeat; Region: RHS_repeat; cl11982
179408019019	RHS Repeat; Region: RHS_repeat; pfam05593
179408019020	RHS Repeat; Region: RHS_repeat; pfam05593
179408019021	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
179408019022	RHS Repeat; Region: RHS_repeat; pfam05593
179408019023	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
179408019024	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
179408019025	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
179408019026	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
179408019027	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
179408019028	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
179408019029	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
179408019030	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
179408019031	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
179408019032	RHS Repeat; Region: RHS_repeat; cl11982
179408019033	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
179408019034	RHS Repeat; Region: RHS_repeat; pfam05593
179408019035	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
179408019036	RHS Repeat; Region: RHS_repeat; pfam05593
179408019037	RHS Repeat; Region: RHS_repeat; pfam05593
179408019038	RHS Repeat; Region: RHS_repeat; pfam05593
179408019039	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
179408019040	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
179408019041	active site
179408019042	DNA binding site [nucleotide binding]
179408019043	Int/Topo IB signature motif; other site
179408019044	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
179408019045	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
179408019046	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
179408019047	P-loop; other site
179408019048	Magnesium ion binding site [ion binding]; other site
179408019049	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
179408019050	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
179408019051	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408019052	ParB-like nuclease domain; Region: ParBc; cl02129
179408019053	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
179408019054	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
179408019055	Uncharacterized conserved protein [Function unknown]; Region: COG4933
179408019056	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
179408019057	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
179408019058	putative active site [active]
179408019059	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
179408019060	D5 N terminal like; Region: D5_N; pfam08706
179408019061	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
179408019062	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408019063	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408019064	Probable transposase; Region: OrfB_IS605; pfam01385
179408019065	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408019066	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
179408019067	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
179408019068	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
179408019069	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
179408019070	active site
179408019071	substrate binding site [chemical binding]; other site
179408019072	Mg2+ binding site [ion binding]; other site
179408019073	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408019074	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408019075	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408019076	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408019077	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408019078	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
179408019079	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408019080	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408019081	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
179408019082	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
179408019083	active site
179408019084	substrate binding site [chemical binding]; other site
179408019085	Mg2+ binding site [ion binding]; other site
179408019086	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408019087	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
179408019088	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
179408019089	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
179408019090	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
179408019091	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
179408019092	putative active site [active]
179408019093	putative NTP binding site [chemical binding]; other site
179408019094	putative nucleic acid binding site [nucleotide binding]; other site
179408019095	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
179408019096	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
179408019097	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
179408019098	active site
179408019099	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
179408019100	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
179408019101	active site
179408019102	DNA binding site [nucleotide binding]
179408019103	Int/Topo IB signature motif; other site
179408019104	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
179408019105	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
179408019106	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
179408019107	P-loop; other site
179408019108	Magnesium ion binding site [ion binding]; other site
179408019109	Pirin-related protein [General function prediction only]; Region: COG1741
179408019110	Pirin; Region: Pirin; pfam02678
179408019111	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
179408019112	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
179408019113	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
179408019114	active site
179408019115	DNA binding site [nucleotide binding]
179408019116	Int/Topo IB signature motif; other site
179408019117	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
179408019118	D5 N terminal like; Region: D5_N; smart00885
179408019119	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
179408019120	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
179408019121	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
179408019122	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
179408019123	ATP binding site [chemical binding]; other site
179408019124	putative Mg++ binding site [ion binding]; other site
179408019125	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
179408019126	nucleotide binding region [chemical binding]; other site
179408019127	ATP-binding site [chemical binding]; other site
179408019128	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
179408019129	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
179408019130	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
179408019131	active site
179408019132	Int/Topo IB signature motif; other site
179408019133	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
179408019134	active site
179408019135	metal binding site [ion binding]; metal-binding site
179408019136	interdomain interaction site; other site
179408019137	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
179408019138	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
179408019139	Probable transposase; Region: OrfB_IS605; pfam01385
179408019140	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408019141	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
179408019142	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
179408019143	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
179408019144	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
179408019145	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
179408019146	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408019147	active site
179408019148	phosphorylation site [posttranslational modification]
179408019149	intermolecular recognition site; other site
179408019150	dimerization interface [polypeptide binding]; other site
179408019151	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
179408019152	DNA binding site [nucleotide binding]
179408019153	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
179408019154	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408019155	dimer interface [polypeptide binding]; other site
179408019156	phosphorylation site [posttranslational modification]
179408019157	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408019158	ATP binding site [chemical binding]; other site
179408019159	Mg2+ binding site [ion binding]; other site
179408019160	G-X-G motif; other site
179408019161	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
179408019162	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
179408019163	Low molecular weight phosphatase family; Region: LMWPc; cd00115
179408019164	active site
179408019165	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
179408019166	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
179408019167	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
179408019168	active site
179408019169	catalytic residues [active]
179408019170	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
179408019171	amphipathic channel; other site
179408019172	Asn-Pro-Ala signature motifs; other site
179408019173	PBP superfamily domain; Region: PBP_like_2; cl17296
179408019174	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
179408019175	dimerization interface [polypeptide binding]; other site
179408019176	putative DNA binding site [nucleotide binding]; other site
179408019177	putative Zn2+ binding site [ion binding]; other site
179408019178	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
179408019179	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
179408019180	DNA binding residues [nucleotide binding]
179408019181	dimer interface [polypeptide binding]; other site
179408019182	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
179408019183	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
179408019184	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
179408019185	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408019186	active site
179408019187	phosphorylation site [posttranslational modification]
179408019188	intermolecular recognition site; other site
179408019189	dimerization interface [polypeptide binding]; other site
179408019190	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
179408019191	DNA binding residues [nucleotide binding]
179408019192	dimerization interface [polypeptide binding]; other site
179408019193	Response regulator receiver domain; Region: Response_reg; pfam00072
179408019194	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408019195	active site
179408019196	phosphorylation site [posttranslational modification]
179408019197	intermolecular recognition site; other site
179408019198	dimerization interface [polypeptide binding]; other site
179408019199	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408019200	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408019201	dimer interface [polypeptide binding]; other site
179408019202	phosphorylation site [posttranslational modification]
179408019203	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408019204	ATP binding site [chemical binding]; other site
179408019205	Mg2+ binding site [ion binding]; other site
179408019206	G-X-G motif; other site
179408019207	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
179408019208	ParB-like nuclease domain; Region: ParBc; pfam02195
179408019209	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
179408019210	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
179408019211	P-loop; other site
179408019212	Magnesium ion binding site [ion binding]; other site
179408019213	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
179408019214	Magnesium ion binding site [ion binding]; other site
179408019215	Vacuolar protein sorting-associated protein 35; Region: Vps35; pfam03635
179408019216	Domain of unknown function (DUF955); Region: DUF955; pfam06114
179408019217	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
179408019218	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
179408019219	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
179408019220	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
179408019221	ATP binding site [chemical binding]; other site
179408019222	substrate interface [chemical binding]; other site
179408019223	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
179408019224	HsdM N-terminal domain; Region: HsdM_N; pfam12161
179408019225	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408019226	S-adenosylmethionine binding site [chemical binding]; other site
179408019227	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
179408019228	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
179408019229	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
179408019230	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
179408019231	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
179408019232	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
179408019233	ATP binding site [chemical binding]; other site
179408019234	putative Mg++ binding site [ion binding]; other site
179408019235	Protein of unknown function DUF45; Region: DUF45; pfam01863
179408019236	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
179408019237	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
179408019238	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
179408019239	Probable transposase; Region: OrfB_IS605; pfam01385
179408019240	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408019241	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
179408019242	Ycf46; Provisional; Region: ycf46; CHL00195
179408019243	ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004
179408019244	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133
179408019245	putative active site [active]
179408019246	putative catalytic site [active]
179408019247	Catalytic domain of Protein Kinases; Region: PKc; cd00180
179408019248	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
179408019249	active site
179408019250	ATP binding site [chemical binding]; other site
179408019251	substrate binding site [chemical binding]; other site
179408019252	activation loop (A-loop); other site
179408019253	AAA domain; Region: AAA_11; pfam13086
179408019254	Part of AAA domain; Region: AAA_19; pfam13245
179408019255	AAA domain; Region: AAA_11; pfam13086
179408019256	AAA domain; Region: AAA_12; pfam13087
179408019257	bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975
179408019258	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
179408019259	catalytic site [active]
179408019260	putative active site [active]
179408019261	putative substrate binding site [chemical binding]; other site
179408019262	Phylum Aquificae Pol A is different from Escherichia coli  Pol A by three signature sequences; Region: DNA_pol_A_Aquificae_like; cd08639
179408019263	active site
179408019264	DNA binding site [nucleotide binding]
179408019265	catalytic site [active]
179408019266	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
179408019267	S-adenosylmethionine binding site [chemical binding]; other site
179408019268	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
179408019269	Probable transposase; Region: OrfB_IS605; pfam01385
179408019270	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
179408019271	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
179408019272	Transposase [DNA replication, recombination, and repair]; Region: COG5421
179408019273	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
179408019274	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
179408019275	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
179408019276	AF-4 proto-oncoprotein; Region: AF-4; pfam05110
179408019277	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
179408019278	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
179408019279	metal ion-dependent adhesion site (MIDAS); other site
179408019280	Putative Ig domain; Region: He_PIG; pfam05345
179408019281	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
179408019282	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
179408019283	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
179408019284	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
179408019285	RHS Repeat; Region: RHS_repeat; pfam05593
179408019286	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
179408019287	RHS Repeat; Region: RHS_repeat; pfam05593
179408019288	RHS Repeat; Region: RHS_repeat; pfam05593
179408019289	RHS Repeat; Region: RHS_repeat; pfam05593
179408019290	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
179408019291	RHS Repeat; Region: RHS_repeat; pfam05593
179408019292	RHS Repeat; Region: RHS_repeat; pfam05593
179408019293	RHS Repeat; Region: RHS_repeat; cl11982
179408019294	RHS Repeat; Region: RHS_repeat; pfam05593
179408019295	RHS Repeat; Region: RHS_repeat; pfam05593
179408019296	RHS Repeat; Region: RHS_repeat; pfam05593
179408019297	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
179408019298	HicB family; Region: HicB; pfam05534
179408019299	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
179408019300	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
179408019301	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
179408019302	P-loop; other site
179408019303	Magnesium ion binding site [ion binding]; other site
179408019304	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
179408019305	active site
179408019306	Int/Topo IB signature motif; other site
179408019307	DNA binding site [nucleotide binding]
179408019308	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
179408019309	transcription termination factor Rho; Provisional; Region: rho; PRK09376
179408019310	Uncharacterized conserved protein [Function unknown]; Region: COG4933
179408019311	Ribbon-helix-helix domain; Region: RHH_4; cl01775
179408019312	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
179408019313	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
179408019314	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
179408019315	D5 N terminal like; Region: D5_N; smart00885
179408019316	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
179408019317	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
179408019318	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
179408019319	AF-4 proto-oncoprotein; Region: AF-4; pfam05110
179408019320	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
179408019321	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
179408019322	metal ion-dependent adhesion site (MIDAS); other site
179408019323	Putative Ig domain; Region: He_PIG; pfam05345
179408019324	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
179408019325	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
179408019326	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
179408019327	RHS Repeat; Region: RHS_repeat; pfam05593
179408019328	RHS Repeat; Region: RHS_repeat; pfam05593
179408019329	RHS Repeat; Region: RHS_repeat; pfam05593
179408019330	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
179408019331	RHS Repeat; Region: RHS_repeat; pfam05593
179408019332	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
179408019333	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
179408019334	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
179408019335	RHS Repeat; Region: RHS_repeat; pfam05593
179408019336	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
179408019337	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
179408019338	protein-splicing catalytic site; other site
179408019339	thioester formation/cholesterol transfer; other site
179408019340	Pretoxin HINT domain; Region: PT-HINT; pfam07591
179408019341	Immunity protein Imm5; Region: Imm5; pfam14423
179408019342	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
179408019343	thioester formation/cholesterol transfer; other site
179408019344	protein-splicing catalytic site; other site
179408019345	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412
179408019346	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
179408019347	thioester formation/cholesterol transfer; other site
179408019348	protein-splicing catalytic site; other site
179408019349	ParB-like nuclease domain; Region: ParB; smart00470
179408019350	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
179408019351	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
179408019352	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408019353	Walker A motif; other site
179408019354	ATP binding site [chemical binding]; other site
179408019355	Walker B motif; other site
179408019356	arginine finger; other site
179408019357	DNA polymerase III subunit beta; Validated; Region: PRK05643
179408019358	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
179408019359	putative DNA binding surface [nucleotide binding]; other site
179408019360	dimer interface [polypeptide binding]; other site
179408019361	beta-clamp/clamp loader binding surface; other site
179408019362	beta-clamp/translesion DNA polymerase binding surface; other site
179408019363	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
179408019364	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
179408019365	ATP-binding site [chemical binding]; other site
179408019366	Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611
179408019367	XisH protein; Region: XisH; pfam08814
179408019368	XisI protein; Region: XisI; pfam08869
179408019369	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
179408019370	ATP binding site [chemical binding]; other site
179408019371	putative Mg++ binding site [ion binding]; other site
179408019372	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
179408019373	nucleotide binding region [chemical binding]; other site
179408019374	ATP-binding site [chemical binding]; other site
179408019375	AAA domain; Region: AAA_30; pfam13604
179408019376	Family description; Region: UvrD_C_2; pfam13538
179408019377	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
179408019378	iron-sulfur cluster [ion binding]; other site
179408019379	[2Fe-2S] cluster binding site [ion binding]; other site
179408019380	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
179408019381	active site
179408019382	catalytic residues [active]
179408019383	DNA binding site [nucleotide binding]
179408019384	Int/Topo IB signature motif; other site
179408019385	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
179408019386	active site
179408019387	metal binding site [ion binding]; metal-binding site
179408019388	interdomain interaction site; other site
179408019389	Origin of replication binding protein; Region: Herpes_ori_bp; pfam02399
179408019390	DNA damage checkpoint protein; Region: LCD1; pfam09798
179408019391	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
179408019392	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
179408019393	non-specific DNA binding site [nucleotide binding]; other site
179408019394	salt bridge; other site
179408019395	sequence-specific DNA binding site [nucleotide binding]; other site
179408019396	sequence-specific DNA binding site [nucleotide binding]; other site
179408019397	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
179408019398	salt bridge; other site
179408019399	DDE superfamily endonuclease; Region: DDE_3; pfam13358
179408019400	Homeodomain-like domain; Region: HTH_23; pfam13384
179408019401	Winged helix-turn helix; Region: HTH_29; pfam13551
179408019402	AAA-like domain; Region: AAA_10; pfam12846
179408019403	XisI protein; Region: XisI; pfam08869
179408019404	XisH protein; Region: XisH; pfam08814
179408019405	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
179408019406	Caspase domain; Region: Peptidase_C14; pfam00656
179408019407	PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736
179408019408	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
179408019409	ATP binding site [chemical binding]; other site
179408019410	substrate interface [chemical binding]; other site
179408019411	Prokaryotic E2 family D; Region: Prok-E2_D; cl14019
179408019412	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
179408019413	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
179408019414	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
179408019415	putative active site [active]
179408019416	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
179408019417	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
179408019418	generic binding surface II; other site
179408019419	ssDNA binding site; other site
179408019420	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
179408019421	ATP binding site [chemical binding]; other site
179408019422	putative Mg++ binding site [ion binding]; other site
179408019423	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
179408019424	nucleotide binding region [chemical binding]; other site
179408019425	ATP-binding site [chemical binding]; other site
179408019426	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
179408019427	Mg binding site [ion binding]; other site
179408019428	nucleotide binding site [chemical binding]; other site
179408019429	putative protofilament interface [polypeptide binding]; other site
179408019430	conjugal transfer protein TraL; Provisional; Region: PRK13886
179408019431	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
179408019432	DEAD/DEAH box helicase; Region: DEAD; pfam00270
179408019433	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
179408019434	Coenzyme A binding pocket [chemical binding]; other site
179408019435	hypothetical protein; Region: PHA01745
179408019436	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
179408019437	metal-binding site [ion binding]
179408019438	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
179408019439	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
179408019440	DNA binding residues [nucleotide binding]
179408019441	Plastocyanin domain containing protein [General function prediction only]; Region: COG4633
179408019442	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
179408019443	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
179408019444	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
179408019445	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
179408019446	metal-binding site [ion binding]
179408019447	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
179408019448	Soluble P-type ATPase [General function prediction only]; Region: COG4087
179408019449	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
179408019450	metal-binding site [ion binding]
179408019451	manganese transport protein MntH; Reviewed; Region: PRK00701
179408019452	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
179408019453	Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916
179408019454	putative active site [active]
179408019455	substrate binding site [chemical binding]; other site
179408019456	redox center [active]
179408019457	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
179408019458	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
179408019459	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
179408019460	Soluble P-type ATPase [General function prediction only]; Region: COG4087
179408019461	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
179408019462	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
179408019463	dimerization interface [polypeptide binding]; other site
179408019464	putative DNA binding site [nucleotide binding]; other site
179408019465	putative Zn2+ binding site [ion binding]; other site
179408019466	Domain of unknown function (DUF305); Region: DUF305; pfam03713
179408019467	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
179408019468	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
179408019469	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
179408019470	HlyD family secretion protein; Region: HlyD_3; pfam13437
179408019471	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
179408019472	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
179408019473	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
179408019474	DNA binding residues [nucleotide binding]
179408019475	dimer interface [polypeptide binding]; other site
179408019476	metal binding site [ion binding]; metal-binding site
179408019477	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
179408019478	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
179408019479	dimer interface [polypeptide binding]; other site
179408019480	pyridoxal 5'-phosphate binding site [chemical binding]; other site
179408019481	catalytic residue [active]
179408019482	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
179408019483	Acyltransferase family; Region: Acyl_transf_3; pfam01757
179408019484	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
179408019485	dimerization interface [polypeptide binding]; other site
179408019486	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
179408019487	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
179408019488	putative active site [active]
179408019489	HlyD family secretion protein; Region: HlyD; pfam00529
179408019490	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
179408019491	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
179408019492	HlyD family secretion protein; Region: HlyD_3; pfam13437
179408019493	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
179408019494	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
179408019495	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
179408019496	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
179408019497	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
179408019498	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
179408019499	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
179408019500	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408019501	active site
179408019502	phosphorylation site [posttranslational modification]
179408019503	intermolecular recognition site; other site
179408019504	dimerization interface [polypeptide binding]; other site
179408019505	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
179408019506	DNA binding site [nucleotide binding]
179408019507	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408019508	dimer interface [polypeptide binding]; other site
179408019509	phosphorylation site [posttranslational modification]
179408019510	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408019511	ATP binding site [chemical binding]; other site
179408019512	Mg2+ binding site [ion binding]; other site
179408019513	G-X-G motif; other site
179408019514	Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943
179408019515	nucleotide binding site [chemical binding]; other site
179408019516	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
179408019517	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
179408019518	salt bridge; other site
179408019519	non-specific DNA binding site [nucleotide binding]; other site
179408019520	sequence-specific DNA binding site [nucleotide binding]; other site
179408019521	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
179408019522	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
179408019523	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408019524	Walker A motif; other site
179408019525	ATP binding site [chemical binding]; other site
179408019526	Walker B motif; other site
179408019527	arginine finger; other site
179408019528	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
179408019529	AAA domain; Region: AAA_30; pfam13604
179408019530	Family description; Region: UvrD_C_2; pfam13538
179408019531	DNA polymerase III subunit beta; Validated; Region: PRK05643
179408019532	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
179408019533	putative DNA binding surface [nucleotide binding]; other site
179408019534	dimer interface [polypeptide binding]; other site
179408019535	beta-clamp/clamp loader binding surface; other site
179408019536	beta-clamp/translesion DNA polymerase binding surface; other site
179408019537	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
179408019538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408019539	active site
179408019540	phosphorylation site [posttranslational modification]
179408019541	intermolecular recognition site; other site
179408019542	dimerization interface [polypeptide binding]; other site
179408019543	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
179408019544	DNA binding residues [nucleotide binding]
179408019545	dimerization interface [polypeptide binding]; other site
179408019546	Response regulator receiver domain; Region: Response_reg; pfam00072
179408019547	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408019548	active site
179408019549	phosphorylation site [posttranslational modification]
179408019550	intermolecular recognition site; other site
179408019551	dimerization interface [polypeptide binding]; other site
179408019552	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408019553	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408019554	dimer interface [polypeptide binding]; other site
179408019555	phosphorylation site [posttranslational modification]
179408019556	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408019557	ATP binding site [chemical binding]; other site
179408019558	Mg2+ binding site [ion binding]; other site
179408019559	G-X-G motif; other site
179408019560	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
179408019561	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
179408019562	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
179408019563	FOG: WD40 repeat [General function prediction only]; Region: COG2319
179408019564	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
179408019565	structural tetrad; other site
179408019566	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
179408019567	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
179408019568	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
179408019569	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408019570	Walker A motif; other site
179408019571	ATP binding site [chemical binding]; other site
179408019572	Walker B motif; other site
179408019573	arginine finger; other site
179408019574	phage tail protein domain; Region: tail_TIGR02242
179408019575	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
179408019576	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
179408019577	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
179408019578	AAR2 protein; Region: AAR2; pfam05282
179408019579	AAR2 protein; Region: AAR2; pfam05282
179408019580	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
179408019581	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
179408019582	DDE superfamily endonuclease; Region: DDE_3; pfam13358
179408019583	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
179408019584	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
179408019585	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
179408019586	Walker A motif; other site
179408019587	ATP binding site [chemical binding]; other site
179408019588	Walker B motif; other site
179408019589	arginine finger; other site
179408019590	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
179408019591	DDE superfamily endonuclease; Region: DDE_3; pfam13358
179408019592	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
179408019593	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
179408019594	DDE superfamily endonuclease; Region: DDE_3; pfam13358
179408019595	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
179408019596	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
179408019597	dimerization interface [polypeptide binding]; other site
179408019598	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
179408019599	dimer interface [polypeptide binding]; other site
179408019600	phosphorylation site [posttranslational modification]
179408019601	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
179408019602	ATP binding site [chemical binding]; other site
179408019603	Mg2+ binding site [ion binding]; other site
179408019604	G-X-G motif; other site
179408019605	Response regulator receiver domain; Region: Response_reg; pfam00072
179408019606	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
179408019607	active site
179408019608	phosphorylation site [posttranslational modification]
179408019609	intermolecular recognition site; other site
179408019610	dimerization interface [polypeptide binding]; other site
179408019611	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
179408019612	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
179408019613	P-loop; other site
179408019614	Magnesium ion binding site [ion binding]; other site
179408019615	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
179408019616	Magnesium ion binding site [ion binding]; other site
179408019617	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
179408019618	ParB-like nuclease domain; Region: ParBc; pfam02195
179408019619	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
179408019620	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
179408019621	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
179408019622	active site
179408019623	Int/Topo IB signature motif; other site
179408019624	DNA binding site [nucleotide binding]