-- dump date 20140619_224953 -- class Genbank::misc_feature -- table misc_feature_note -- id note 926562000001 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 926562000002 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 926562000003 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 926562000004 HsdM N-terminal domain; Region: HsdM_N; pfam12161 926562000005 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 926562000006 Methyltransferase domain; Region: Methyltransf_26; pfam13659 926562000007 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 926562000008 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926562000009 non-specific DNA binding site [nucleotide binding]; other site 926562000010 salt bridge; other site 926562000011 sequence-specific DNA binding site [nucleotide binding]; other site 926562000012 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 926562000013 Catalytic site [active] 926562000014 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 926562000015 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 926562000016 active site 926562000017 DNA binding site [nucleotide binding] 926562000018 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 926562000019 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 926562000020 active site 926562000021 PHP Thumb interface [polypeptide binding]; other site 926562000022 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 926562000023 hypothetical protein; Validated; Region: PRK08116 926562000024 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 926562000025 active site 926562000026 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 926562000027 active site 926562000028 catalytic residues [active] 926562000029 DNA binding site [nucleotide binding] 926562000030 Int/Topo IB signature motif; other site 926562000031 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 926562000032 Predicted membrane protein [Function unknown]; Region: COG4325 926562000033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926562000034 Walker A/P-loop; other site 926562000035 ATP binding site [chemical binding]; other site 926562000036 Q-loop/lid; other site 926562000037 ABC transporter signature motif; other site 926562000038 Walker B; other site 926562000039 D-loop; other site 926562000040 H-loop/switch region; other site 926562000041 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 926562000042 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 926562000043 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 926562000044 TrkA-N domain; Region: TrkA_N; pfam02254 926562000045 TrkA-C domain; Region: TrkA_C; pfam02080 926562000046 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 926562000047 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 926562000048 DOMON domain; Region: DOMON; pfam03351 926562000049 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 926562000050 putative ligand binding site [chemical binding]; other site 926562000051 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562000052 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 926562000053 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 926562000054 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 926562000055 Protein of unknown function, DUF481; Region: DUF481; cl01213 926562000056 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 926562000057 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 926562000058 Surface antigen; Region: Bac_surface_Ag; pfam01103 926562000059 Uncharacterized conserved protein [Function unknown]; Region: COG1262 926562000060 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 926562000061 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926562000062 Sulfatase; Region: Sulfatase; pfam00884 926562000063 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 926562000064 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 926562000065 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926562000066 Sulfatase; Region: Sulfatase; pfam00884 926562000067 MoxR-like ATPases [General function prediction only]; Region: COG0714 926562000068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562000069 Walker A motif; other site 926562000070 ATP binding site [chemical binding]; other site 926562000071 Walker B motif; other site 926562000072 arginine finger; other site 926562000073 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 926562000074 Protein of unknown function DUF58; Region: DUF58; pfam01882 926562000075 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 926562000076 metal ion-dependent adhesion site (MIDAS); other site 926562000077 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 926562000078 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 926562000079 metal ion-dependent adhesion site (MIDAS); other site 926562000080 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 926562000081 von Willebrand factor type A domain; Region: VWA_2; pfam13519 926562000082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562000083 binding surface 926562000084 TPR motif; other site 926562000085 TPR repeat; Region: TPR_11; pfam13414 926562000086 Oxygen tolerance; Region: BatD; pfam13584 926562000087 Surface antigen; Region: Bac_surface_Ag; pfam01103 926562000088 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 926562000089 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 926562000090 Ligand Binding Site [chemical binding]; other site 926562000091 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 926562000092 Ligand Binding Site [chemical binding]; other site 926562000093 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926562000094 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926562000095 Zn2+ binding site [ion binding]; other site 926562000096 Mg2+ binding site [ion binding]; other site 926562000097 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 926562000098 DEAD-like helicases superfamily; Region: DEXDc; smart00487 926562000099 ATP binding site [chemical binding]; other site 926562000100 putative Mg++ binding site [ion binding]; other site 926562000101 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 926562000102 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 926562000103 putative active site [active] 926562000104 Zn binding site [ion binding]; other site 926562000105 flavoprotein, HI0933 family; Region: TIGR00275 926562000106 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 926562000107 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562000108 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562000109 binding surface 926562000110 TPR motif; other site 926562000111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 926562000112 binding surface 926562000113 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562000114 TPR motif; other site 926562000115 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 926562000116 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 926562000117 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 926562000118 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 926562000119 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 926562000120 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 926562000121 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562000122 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 926562000123 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 926562000124 metal-binding site [ion binding] 926562000125 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 926562000126 Soluble P-type ATPase [General function prediction only]; Region: COG4087 926562000127 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 926562000128 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 926562000129 classical (c) SDRs; Region: SDR_c; cd05233 926562000130 NAD(P) binding site [chemical binding]; other site 926562000131 active site 926562000132 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 926562000133 Uncharacterized conserved protein [Function unknown]; Region: COG4933 926562000134 Type III pantothenate kinase; Region: Pan_kinase; cl17198 926562000135 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 926562000136 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 926562000137 Domain of unknown function DUF21; Region: DUF21; pfam01595 926562000138 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 926562000139 Transporter associated domain; Region: CorC_HlyC; smart01091 926562000140 SurA N-terminal domain; Region: SurA_N_3; cl07813 926562000141 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 926562000142 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 926562000143 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 926562000144 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 926562000145 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 926562000146 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 926562000147 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 926562000148 rod shape-determining protein MreC; Provisional; Region: PRK13922 926562000149 rod shape-determining protein MreC; Region: MreC; pfam04085 926562000150 rod shape-determining protein MreB; Provisional; Region: PRK13927 926562000151 MreB and similar proteins; Region: MreB_like; cd10225 926562000152 nucleotide binding site [chemical binding]; other site 926562000153 Mg binding site [ion binding]; other site 926562000154 putative protofilament interaction site [polypeptide binding]; other site 926562000155 RodZ interaction site [polypeptide binding]; other site 926562000156 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 926562000157 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 926562000158 purine monophosphate binding site [chemical binding]; other site 926562000159 dimer interface [polypeptide binding]; other site 926562000160 putative catalytic residues [active] 926562000161 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 926562000162 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 926562000163 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926562000164 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 926562000165 FtsX-like permease family; Region: FtsX; pfam02687 926562000166 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 926562000167 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926562000168 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 926562000169 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4020; cl07907 926562000170 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562000171 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 926562000172 Sporulation related domain; Region: SPOR; pfam05036 926562000173 DinB superfamily; Region: DinB_2; pfam12867 926562000174 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 926562000175 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 926562000176 active site 926562000177 Zn binding site [ion binding]; other site 926562000178 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 926562000179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562000180 S-adenosylmethionine binding site [chemical binding]; other site 926562000181 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 926562000182 MgtE intracellular N domain; Region: MgtE_N; smart00924 926562000183 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 926562000184 Divalent cation transporter; Region: MgtE; pfam01769 926562000185 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 926562000186 mechanosensitive channel MscS; Provisional; Region: PRK10334 926562000187 Mechanosensitive ion channel; Region: MS_channel; pfam00924 926562000188 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 926562000189 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_14; cd12179 926562000190 putative ligand binding site [chemical binding]; other site 926562000191 putative NAD binding site [chemical binding]; other site 926562000192 catalytic site [active] 926562000193 Predicted acetyltransferase [General function prediction only]; Region: COG2388 926562000194 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 926562000195 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 926562000196 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 926562000197 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926562000198 YCII-related domain; Region: YCII; cl00999 926562000199 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926562000200 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 926562000201 HlyD family secretion protein; Region: HlyD_3; pfam13437 926562000202 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 926562000203 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 926562000204 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 926562000205 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 926562000206 Predicted transcriptional regulators [Transcription]; Region: COG1695 926562000207 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 926562000208 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 926562000209 O-Antigen ligase; Region: Wzy_C; pfam04932 926562000210 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562000211 TPR motif; other site 926562000212 binding surface 926562000213 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562000214 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562000215 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 926562000216 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926562000217 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 926562000218 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 926562000219 putative NAD(P) binding site [chemical binding]; other site 926562000220 homodimer interface [polypeptide binding]; other site 926562000221 Cupin domain; Region: Cupin_2; pfam07883 926562000222 Helix-turn-helix domain; Region: HTH_18; pfam12833 926562000223 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926562000224 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 926562000225 active site 926562000226 metal binding site [ion binding]; metal-binding site 926562000227 homotetramer interface [polypeptide binding]; other site 926562000228 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 926562000229 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 926562000230 dimerization interface 3.5A [polypeptide binding]; other site 926562000231 active site 926562000232 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 926562000233 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926562000234 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 926562000235 Walker A/P-loop; other site 926562000236 ATP binding site [chemical binding]; other site 926562000237 Q-loop/lid; other site 926562000238 ABC transporter signature motif; other site 926562000239 Walker B; other site 926562000240 D-loop; other site 926562000241 H-loop/switch region; other site 926562000242 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 926562000243 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 926562000244 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 926562000245 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 926562000246 HSP70 interaction site [polypeptide binding]; other site 926562000247 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 926562000248 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 926562000249 dimer interface [polypeptide binding]; other site 926562000250 active site 926562000251 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 926562000252 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 926562000253 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 926562000254 active site 926562000255 Substrate binding site; other site 926562000256 Mg++ binding site; other site 926562000257 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 926562000258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926562000259 active site 926562000260 motif I; other site 926562000261 motif II; other site 926562000262 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 926562000263 active site 926562000264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 926562000265 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 926562000266 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 926562000267 Peptidase S8 family domain, uncharacterized subfamily 9; Region: Peptidases_S8_9; cd07493 926562000268 active site 926562000269 catalytic triad [active] 926562000270 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562000271 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 926562000272 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 926562000273 FMN binding site [chemical binding]; other site 926562000274 substrate binding site [chemical binding]; other site 926562000275 putative catalytic residue [active] 926562000276 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 926562000277 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 926562000278 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 926562000279 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 926562000280 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 926562000281 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 926562000282 active site 926562000283 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 926562000284 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 926562000285 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 926562000286 SurA N-terminal domain; Region: SurA_N; pfam09312 926562000287 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 926562000288 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 926562000289 MoxR-like ATPases [General function prediction only]; Region: COG0714 926562000290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562000291 Walker A motif; other site 926562000292 ATP binding site [chemical binding]; other site 926562000293 Walker B motif; other site 926562000294 arginine finger; other site 926562000295 CTP synthetase; Validated; Region: pyrG; PRK05380 926562000296 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 926562000297 Catalytic site [active] 926562000298 active site 926562000299 UTP binding site [chemical binding]; other site 926562000300 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 926562000301 active site 926562000302 putative oxyanion hole; other site 926562000303 catalytic triad [active] 926562000304 membrane protein insertase; Provisional; Region: PRK01318 926562000305 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 926562000306 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 926562000307 putative catalytic site [active] 926562000308 putative metal binding site [ion binding]; other site 926562000309 putative phosphate binding site [ion binding]; other site 926562000310 CheB methylesterase; Region: CheB_methylest; pfam01339 926562000311 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 926562000312 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 926562000313 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 926562000314 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 926562000315 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 926562000316 active site 926562000317 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 926562000318 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 926562000319 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926562000320 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926562000321 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 926562000322 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 926562000323 active site 926562000324 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562000325 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 926562000326 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926562000327 Walker A/P-loop; other site 926562000328 ATP binding site [chemical binding]; other site 926562000329 Q-loop/lid; other site 926562000330 ABC transporter signature motif; other site 926562000331 Walker B; other site 926562000332 D-loop; other site 926562000333 H-loop/switch region; other site 926562000334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 926562000335 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 926562000336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562000337 binding surface 926562000338 TPR motif; other site 926562000339 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 926562000340 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 926562000341 binding surface 926562000342 TPR motif; other site 926562000343 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 926562000344 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562000345 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 926562000346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562000347 ATP binding site [chemical binding]; other site 926562000348 Mg2+ binding site [ion binding]; other site 926562000349 G-X-G motif; other site 926562000350 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 926562000351 anchoring element; other site 926562000352 dimer interface [polypeptide binding]; other site 926562000353 ATP binding site [chemical binding]; other site 926562000354 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 926562000355 active site 926562000356 putative metal-binding site [ion binding]; other site 926562000357 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 926562000358 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 926562000359 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 926562000360 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 926562000361 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 926562000362 putative NAD(P) binding site [chemical binding]; other site 926562000363 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562000364 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562000365 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 926562000366 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 926562000367 homodimer interface [polypeptide binding]; other site 926562000368 putative substrate binding pocket [chemical binding]; other site 926562000369 diiron center [ion binding]; other site 926562000370 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 926562000371 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 926562000372 putative acyl-acceptor binding pocket; other site 926562000373 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562000374 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562000375 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 926562000376 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 926562000377 transcription termination factor Rho; Provisional; Region: PRK12608 926562000378 RNA binding site [nucleotide binding]; other site 926562000379 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 926562000380 multimer interface [polypeptide binding]; other site 926562000381 Walker A motif; other site 926562000382 ATP binding site [chemical binding]; other site 926562000383 Walker B motif; other site 926562000384 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 926562000385 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 926562000386 Maf-like protein; Region: Maf; pfam02545 926562000387 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 926562000388 active site 926562000389 dimer interface [polypeptide binding]; other site 926562000390 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 926562000391 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 926562000392 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 926562000393 UbiA prenyltransferase family; Region: UbiA; pfam01040 926562000394 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926562000395 active site 926562000396 motif I; other site 926562000397 motif II; other site 926562000398 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 926562000399 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562000400 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562000401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 926562000402 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 926562000403 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 926562000404 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 926562000405 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 926562000406 Spore germination protein; Region: Spore_permease; cl17796 926562000407 Amino acid permease; Region: AA_permease_2; pfam13520 926562000408 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 926562000409 CcmE; Region: CcmE; cl00994 926562000410 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 926562000411 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 926562000412 catalytic residues [active] 926562000413 dimer interface [polypeptide binding]; other site 926562000414 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 926562000415 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 926562000416 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 926562000417 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 926562000418 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 926562000419 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 926562000420 active site 926562000421 dimerization interface [polypeptide binding]; other site 926562000422 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926562000423 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 926562000424 Cysteine-rich domain; Region: CCG; pfam02754 926562000425 Cysteine-rich domain; Region: CCG; pfam02754 926562000426 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 926562000427 4Fe-4S binding domain; Region: Fer4_2; pfam12797 926562000428 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 926562000429 mce related protein; Region: MCE; pfam02470 926562000430 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 926562000431 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 926562000432 active site 926562000433 metal binding site [ion binding]; metal-binding site 926562000434 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 926562000435 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 926562000436 Glutamine amidotransferase class-I; Region: GATase; pfam00117 926562000437 glutamine binding [chemical binding]; other site 926562000438 catalytic triad [active] 926562000439 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 926562000440 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 926562000441 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 926562000442 homotrimer interaction site [polypeptide binding]; other site 926562000443 putative active site [active] 926562000444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926562000445 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 926562000446 putative active site [active] 926562000447 heme pocket [chemical binding]; other site 926562000448 PAS domain S-box; Region: sensory_box; TIGR00229 926562000449 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926562000450 putative active site [active] 926562000451 heme pocket [chemical binding]; other site 926562000452 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562000453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562000454 ATP binding site [chemical binding]; other site 926562000455 Mg2+ binding site [ion binding]; other site 926562000456 G-X-G motif; other site 926562000457 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 926562000458 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 926562000459 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 926562000460 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926562000461 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 926562000462 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 926562000463 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926562000464 ligand binding site [chemical binding]; other site 926562000465 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926562000466 ligand binding site [chemical binding]; other site 926562000467 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 926562000468 Patatin-like phospholipase; Region: Patatin; pfam01734 926562000469 Fasciclin domain; Region: Fasciclin; pfam02469 926562000470 Fasciclin domain; Region: Fasciclin; cl02663 926562000471 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 926562000472 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926562000473 Walker A/P-loop; other site 926562000474 ATP binding site [chemical binding]; other site 926562000475 Q-loop/lid; other site 926562000476 ABC transporter signature motif; other site 926562000477 Walker B; other site 926562000478 D-loop; other site 926562000479 H-loop/switch region; other site 926562000480 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 926562000481 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 926562000482 acyl-activating enzyme (AAE) consensus motif; other site 926562000483 AMP binding site [chemical binding]; other site 926562000484 active site 926562000485 CoA binding site [chemical binding]; other site 926562000486 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 926562000487 Condensation domain; Region: Condensation; pfam00668 926562000488 Phosphopantetheine attachment site; Region: PP-binding; cl09936 926562000489 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 926562000490 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 926562000491 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 926562000492 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 926562000493 Walker A/P-loop; other site 926562000494 ATP binding site [chemical binding]; other site 926562000495 Q-loop/lid; other site 926562000496 ABC transporter signature motif; other site 926562000497 Walker B; other site 926562000498 D-loop; other site 926562000499 H-loop/switch region; other site 926562000500 phytoene desaturase; Region: crtI_fam; TIGR02734 926562000501 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 926562000502 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 926562000503 putative active site [active] 926562000504 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 926562000505 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 926562000506 dimer interface [polypeptide binding]; other site 926562000507 ssDNA binding site [nucleotide binding]; other site 926562000508 tetramer (dimer of dimers) interface [polypeptide binding]; other site 926562000509 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 926562000510 dimer interface [polypeptide binding]; other site 926562000511 substrate binding site [chemical binding]; other site 926562000512 metal binding sites [ion binding]; metal-binding site 926562000513 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 926562000514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926562000515 ATP-grasp domain; Region: ATP-grasp; pfam02222 926562000516 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 926562000517 dimer interface [polypeptide binding]; other site 926562000518 putative tRNA-binding site [nucleotide binding]; other site 926562000519 malate dehydrogenase; Reviewed; Region: PRK06223 926562000520 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 926562000521 dimer interface [polypeptide binding]; other site 926562000522 NAD(P) binding site [chemical binding]; other site 926562000523 tetramer (dimer of dimers) interface [polypeptide binding]; other site 926562000524 substrate binding site [chemical binding]; other site 926562000525 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 926562000526 putative catalytic residues [active] 926562000527 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 926562000528 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 926562000529 Beta-Casp domain; Region: Beta-Casp; smart01027 926562000530 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 926562000531 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 926562000532 nucleoside/Zn binding site; other site 926562000533 dimer interface [polypeptide binding]; other site 926562000534 catalytic motif [active] 926562000535 Domain of unknown function (DUF202); Region: DUF202; pfam02656 926562000536 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 926562000537 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562000538 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 926562000539 Leucine rich repeat; Region: LRR_8; pfam13855 926562000540 Leucine rich repeat; Region: LRR_8; pfam13855 926562000541 Repair protein; Region: Repair_PSII; pfam04536 926562000542 TM1410 hypothetical-related protein; Region: DUF297; cl00997 926562000543 TM1410 hypothetical-related protein; Region: DUF297; cl00997 926562000544 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 926562000545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926562000546 Walker A/P-loop; other site 926562000547 ATP binding site [chemical binding]; other site 926562000548 Q-loop/lid; other site 926562000549 ABC transporter signature motif; other site 926562000550 Walker B; other site 926562000551 D-loop; other site 926562000552 H-loop/switch region; other site 926562000553 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 926562000554 DEAD-like helicases superfamily; Region: DEXDc; smart00487 926562000555 ATP binding site [chemical binding]; other site 926562000556 Mg++ binding site [ion binding]; other site 926562000557 motif III; other site 926562000558 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926562000559 nucleotide binding region [chemical binding]; other site 926562000560 ATP-binding site [chemical binding]; other site 926562000561 putative transposase OrfB; Reviewed; Region: PHA02517 926562000562 Integrase core domain; Region: rve; pfam00665 926562000563 Integrase core domain; Region: rve_3; pfam13683 926562000564 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 926562000565 23S rRNA binding site [nucleotide binding]; other site 926562000566 L21 binding site [polypeptide binding]; other site 926562000567 L13 binding site [polypeptide binding]; other site 926562000568 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 926562000569 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 926562000570 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 926562000571 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 926562000572 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 926562000573 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 926562000574 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 926562000575 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 926562000576 active site 926562000577 dimer interface [polypeptide binding]; other site 926562000578 motif 1; other site 926562000579 motif 2; other site 926562000580 motif 3; other site 926562000581 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 926562000582 anticodon binding site; other site 926562000583 Transcriptional regulator [Transcription]; Region: LysR; COG0583 926562000584 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 926562000585 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 926562000586 putative dimerization interface [polypeptide binding]; other site 926562000587 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 926562000588 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 926562000589 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 926562000590 trimer interface [polypeptide binding]; other site 926562000591 active site 926562000592 substrate binding site [chemical binding]; other site 926562000593 CoA binding site [chemical binding]; other site 926562000594 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 926562000595 active site triad [active] 926562000596 CAAX protease self-immunity; Region: Abi; pfam02517 926562000597 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 926562000598 NADH(P)-binding; Region: NAD_binding_10; pfam13460 926562000599 NAD(P) binding site [chemical binding]; other site 926562000600 putative active site [active] 926562000601 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 926562000602 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 926562000603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926562000604 NADH(P)-binding; Region: NAD_binding_10; pfam13460 926562000605 NAD(P) binding site [chemical binding]; other site 926562000606 active site 926562000607 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 926562000608 Beta-lactamase; Region: Beta-lactamase; pfam00144 926562000609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926562000610 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926562000611 putative substrate translocation pore; other site 926562000612 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 926562000613 Predicted integral membrane protein [Function unknown]; Region: COG5616 926562000614 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 926562000615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562000616 binding surface 926562000617 TPR motif; other site 926562000618 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562000619 TPR motif; other site 926562000620 binding surface 926562000621 Helix-turn-helix domain; Region: HTH_18; pfam12833 926562000622 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926562000623 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 926562000624 RES domain; Region: RES; smart00953 926562000625 Beta protein; Region: Beta_protein; pfam14350 926562000626 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 926562000627 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562000628 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926562000629 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562000630 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 926562000631 catalytic motif [active] 926562000632 Catalytic residue [active] 926562000633 Aspartyl protease; Region: Asp_protease_2; pfam13650 926562000634 inhibitor binding site; inhibition site 926562000635 catalytic motif [active] 926562000636 Catalytic residue [active] 926562000637 Active site flap [active] 926562000638 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 926562000639 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 926562000640 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 926562000641 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 926562000642 putative NAD(P) binding site [chemical binding]; other site 926562000643 Predicted integral membrane protein [Function unknown]; Region: COG5616 926562000644 TPR repeat; Region: TPR_11; pfam13414 926562000645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562000646 TPR motif; other site 926562000647 binding surface 926562000648 TPR repeat; Region: TPR_11; pfam13414 926562000649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562000650 binding surface 926562000651 TPR motif; other site 926562000652 Helix-turn-helix domain; Region: HTH_18; pfam12833 926562000653 haloalkane dehalogenase; Provisional; Region: PRK03204 926562000654 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926562000655 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926562000656 ligand binding site [chemical binding]; other site 926562000657 flexible hinge region; other site 926562000658 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 926562000659 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 926562000660 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 926562000661 Beta-lactamase; Region: Beta-lactamase; pfam00144 926562000662 Peptidase S8 family domain, uncharacterized subfamily 9; Region: Peptidases_S8_9; cd07493 926562000663 active site 926562000664 catalytic triad [active] 926562000665 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562000666 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 926562000667 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562000668 binding surface 926562000669 TPR repeat; Region: TPR_11; pfam13414 926562000670 TPR motif; other site 926562000671 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926562000672 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562000673 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562000674 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 926562000675 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 926562000676 CoenzymeA binding site [chemical binding]; other site 926562000677 subunit interaction site [polypeptide binding]; other site 926562000678 PHB binding site; other site 926562000679 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 926562000680 GxxExxY protein; Region: GxxExxY; TIGR04256 926562000681 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 926562000682 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 926562000683 dimer interface [polypeptide binding]; other site 926562000684 tetramer interface [polypeptide binding]; other site 926562000685 PYR/PP interface [polypeptide binding]; other site 926562000686 TPP binding site [chemical binding]; other site 926562000687 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 926562000688 TPP-binding site; other site 926562000689 Bacterial PH domain; Region: DUF304; cl01348 926562000690 Predicted membrane protein [Function unknown]; Region: COG3428 926562000691 Bacterial PH domain; Region: DUF304; pfam03703 926562000692 Bacterial PH domain; Region: DUF304; pfam03703 926562000693 Bacterial PH domain; Region: DUF304; pfam03703 926562000694 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 926562000695 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 926562000696 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926562000697 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926562000698 ligand binding site [chemical binding]; other site 926562000699 flexible hinge region; other site 926562000700 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 926562000701 Pirin-related protein [General function prediction only]; Region: COG1741 926562000702 Pirin; Region: Pirin; pfam02678 926562000703 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 926562000704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562000705 S-adenosylmethionine binding site [chemical binding]; other site 926562000706 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 926562000707 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 926562000708 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 926562000709 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 926562000710 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 926562000711 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 926562000712 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 926562000713 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 926562000714 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 926562000715 putative metal binding site [ion binding]; other site 926562000716 Uncharacterized conserved protein [Function unknown]; Region: COG1432 926562000717 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 926562000718 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562000719 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562000720 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926562000721 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 926562000722 N-terminal plug; other site 926562000723 ligand-binding site [chemical binding]; other site 926562000724 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 926562000725 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 926562000726 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926562000727 putative catalytic residues [active] 926562000728 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 926562000729 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 926562000730 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 926562000731 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 926562000732 UbiA prenyltransferase family; Region: UbiA; pfam01040 926562000733 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 926562000734 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 926562000735 dimer interface [polypeptide binding]; other site 926562000736 FMN binding site [chemical binding]; other site 926562000737 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 926562000738 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 926562000739 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 926562000740 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 926562000741 active site 926562000742 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 926562000743 AMP binding site [chemical binding]; other site 926562000744 active site 926562000745 acyl-activating enzyme (AAE) consensus motif; other site 926562000746 CoA binding site [chemical binding]; other site 926562000747 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 926562000748 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 926562000749 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Region: LPLAT_AAK14816-like; cd07992 926562000750 putative acyl-acceptor binding pocket; other site 926562000751 bile acid transporter; Region: bass; TIGR00841 926562000752 Sodium Bile acid symporter family; Region: SBF; pfam01758 926562000753 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 926562000754 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926562000755 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 926562000756 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 926562000757 ApbE family; Region: ApbE; pfam02424 926562000758 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 926562000759 Cation efflux family; Region: Cation_efflux; pfam01545 926562000760 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 926562000761 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926562000762 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926562000763 active site 926562000764 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 926562000765 OstA-like protein; Region: OstA_2; pfam13100 926562000766 OstA-like protein; Region: OstA_2; pfam13100 926562000767 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 926562000768 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 926562000769 GDP-binding site [chemical binding]; other site 926562000770 ACT binding site; other site 926562000771 IMP binding site; other site 926562000772 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 926562000773 metal binding site 2 [ion binding]; metal-binding site 926562000774 putative DNA binding helix; other site 926562000775 metal binding site 1 [ion binding]; metal-binding site 926562000776 dimer interface [polypeptide binding]; other site 926562000777 structural Zn2+ binding site [ion binding]; other site 926562000778 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 926562000779 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926562000780 Zn2+ binding site [ion binding]; other site 926562000781 Mg2+ binding site [ion binding]; other site 926562000782 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 926562000783 synthetase active site [active] 926562000784 NTP binding site [chemical binding]; other site 926562000785 metal binding site [ion binding]; metal-binding site 926562000786 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 926562000787 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 926562000788 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 926562000789 Predicted membrane protein [Function unknown]; Region: COG2259 926562000790 GAF domain; Region: GAF; pfam01590 926562000791 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562000792 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562000793 dimer interface [polypeptide binding]; other site 926562000794 phosphorylation site [posttranslational modification] 926562000795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562000796 ATP binding site [chemical binding]; other site 926562000797 Mg2+ binding site [ion binding]; other site 926562000798 G-X-G motif; other site 926562000799 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 926562000800 HSP70 interaction site [polypeptide binding]; other site 926562000801 KTSC domain; Region: KTSC; pfam13619 926562000802 aspartate aminotransferase; Provisional; Region: PRK05764 926562000803 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 926562000804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562000805 homodimer interface [polypeptide binding]; other site 926562000806 catalytic residue [active] 926562000807 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 926562000808 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562000809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562000810 binding surface 926562000811 TPR motif; other site 926562000812 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562000813 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562000814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562000815 binding surface 926562000816 TPR motif; other site 926562000817 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562000818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562000819 binding surface 926562000820 TPR motif; other site 926562000821 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562000822 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562000823 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562000824 dimer interface [polypeptide binding]; other site 926562000825 phosphorylation site [posttranslational modification] 926562000826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562000827 ATP binding site [chemical binding]; other site 926562000828 Mg2+ binding site [ion binding]; other site 926562000829 G-X-G motif; other site 926562000830 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 926562000831 active site 926562000832 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562000833 Predicted transcriptional regulator [Transcription]; Region: COG3655 926562000834 sequence-specific DNA binding site [nucleotide binding]; other site 926562000835 salt bridge; other site 926562000836 DinB superfamily; Region: DinB_2; pfam12867 926562000837 FG-GAP repeat; Region: FG-GAP; cl15299 926562000838 Family description; Region: VCBS; pfam13517 926562000839 Family description; Region: VCBS; pfam13517 926562000840 Family description; Region: VCBS; pfam13517 926562000841 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562000842 Peptidase M15; Region: Peptidase_M15_3; cl01194 926562000843 Predicted membrane protein [Function unknown]; Region: COG2860 926562000844 UPF0126 domain; Region: UPF0126; pfam03458 926562000845 UPF0126 domain; Region: UPF0126; pfam03458 926562000846 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 926562000847 WbqC-like protein family; Region: WbqC; pfam08889 926562000848 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 926562000849 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 926562000850 Catalytic site [active] 926562000851 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 926562000852 dihydrodipicolinate reductase; Provisional; Region: PRK00048 926562000853 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 926562000854 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 926562000855 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 926562000856 ParB-like nuclease domain; Region: ParB; smart00470 926562000857 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 926562000858 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 926562000859 P-loop; other site 926562000860 Magnesium ion binding site [ion binding]; other site 926562000861 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 926562000862 Magnesium ion binding site [ion binding]; other site 926562000863 Predicted flavoprotein [General function prediction only]; Region: COG0431 926562000864 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 926562000865 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 926562000866 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 926562000867 Tetramer interface [polypeptide binding]; other site 926562000868 active site 926562000869 FMN-binding site [chemical binding]; other site 926562000870 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 926562000871 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 926562000872 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 926562000873 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 926562000874 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 926562000875 ATP synthase archaeal, H subunit; Region: AhaH; TIGR02926 926562000876 Ankyrin repeat; Region: Ank; pfam00023 926562000877 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562000878 TPR motif; other site 926562000879 TPR repeat; Region: TPR_11; pfam13414 926562000880 binding surface 926562000881 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926562000882 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 926562000883 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926562000884 ligand binding site [chemical binding]; other site 926562000885 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 926562000886 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 926562000887 methionine sulfoxide reductase B; Provisional; Region: PRK00222 926562000888 SelR domain; Region: SelR; pfam01641 926562000889 PGAP1-like protein; Region: PGAP1; pfam07819 926562000890 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926562000891 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 926562000892 AAA ATPase domain; Region: AAA_15; pfam13175 926562000893 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 926562000894 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 926562000895 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 926562000896 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 926562000897 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 926562000898 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 926562000899 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 926562000900 Kelch motif; Region: Kelch_6; pfam13964 926562000901 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 926562000902 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562000903 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 926562000904 SET domain; Region: SET; pfam00856 926562000905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562000906 TPR repeat; Region: TPR_11; pfam13414 926562000907 binding surface 926562000908 TPR motif; other site 926562000909 Tetratricopeptide repeat; Region: TPR_16; pfam13432 926562000910 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926562000911 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 926562000912 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926562000913 ligand binding site [chemical binding]; other site 926562000914 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 926562000915 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 926562000916 catalytic residues [active] 926562000917 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 926562000918 active site 926562000919 catalytic site [active] 926562000920 substrate binding site [chemical binding]; other site 926562000921 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 926562000922 GIY-YIG motif/motif A; other site 926562000923 active site 926562000924 catalytic site [active] 926562000925 putative DNA binding site [nucleotide binding]; other site 926562000926 metal binding site [ion binding]; metal-binding site 926562000927 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 926562000928 dimer interface [polypeptide binding]; other site 926562000929 FMN binding site [chemical binding]; other site 926562000930 MarR family; Region: MarR_2; cl17246 926562000931 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 926562000932 Predicted membrane protein [Function unknown]; Region: COG4270 926562000933 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 926562000934 TRAM domain; Region: TRAM; pfam01938 926562000935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562000936 S-adenosylmethionine binding site [chemical binding]; other site 926562000937 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 926562000938 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 926562000939 inhibitor-cofactor binding pocket; inhibition site 926562000940 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562000941 catalytic residue [active] 926562000942 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 926562000943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562000944 S-adenosylmethionine binding site [chemical binding]; other site 926562000945 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 926562000946 IHF dimer interface [polypeptide binding]; other site 926562000947 IHF - DNA interface [nucleotide binding]; other site 926562000948 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 926562000949 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 926562000950 putative active site [active] 926562000951 substrate binding site [chemical binding]; other site 926562000952 putative cosubstrate binding site; other site 926562000953 catalytic site [active] 926562000954 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 926562000955 substrate binding site [chemical binding]; other site 926562000956 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 926562000957 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926562000958 ATP binding site [chemical binding]; other site 926562000959 putative Mg++ binding site [ion binding]; other site 926562000960 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926562000961 nucleotide binding region [chemical binding]; other site 926562000962 ATP-binding site [chemical binding]; other site 926562000963 Predicted ATPase [General function prediction only]; Region: COG3911 926562000964 AAA domain; Region: AAA_28; pfam13521 926562000965 Protein of unknown function (DUF493); Region: DUF493; pfam04359 926562000966 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 926562000967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926562000968 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926562000969 putative substrate translocation pore; other site 926562000970 ribonuclease Z; Region: RNase_Z; TIGR02651 926562000971 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562000972 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 926562000973 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 926562000974 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 926562000975 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 926562000976 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926562000977 active site 926562000978 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 926562000979 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 926562000980 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 926562000981 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 926562000982 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 926562000983 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 926562000984 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 926562000985 putative acyl-acceptor binding pocket; other site 926562000986 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 926562000987 putative active site [active] 926562000988 putative CoA binding site [chemical binding]; other site 926562000989 nudix motif; other site 926562000990 metal binding site [ion binding]; metal-binding site 926562000991 Transcriptional regulator [Transcription]; Region: LysR; COG0583 926562000992 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 926562000993 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 926562000994 dimerization interface [polypeptide binding]; other site 926562000995 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 926562000996 active site 926562000997 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 926562000998 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 926562000999 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 926562001000 putative dimer interface [polypeptide binding]; other site 926562001001 Peptidase C1-like family; Region: Peptidase_C1_2; cl17447 926562001002 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562001003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562001004 dimer interface [polypeptide binding]; other site 926562001005 phosphorylation site [posttranslational modification] 926562001006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562001007 ATP binding site [chemical binding]; other site 926562001008 Mg2+ binding site [ion binding]; other site 926562001009 G-X-G motif; other site 926562001010 Divergent AAA domain; Region: AAA_4; pfam04326 926562001011 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562001012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562001013 binding surface 926562001014 TPR motif; other site 926562001015 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562001016 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562001017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562001018 dimer interface [polypeptide binding]; other site 926562001019 phosphorylation site [posttranslational modification] 926562001020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562001021 ATP binding site [chemical binding]; other site 926562001022 Mg2+ binding site [ion binding]; other site 926562001023 G-X-G motif; other site 926562001024 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 926562001025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926562001026 putative substrate translocation pore; other site 926562001027 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 926562001028 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 926562001029 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 926562001030 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562001031 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562001032 dimer interface [polypeptide binding]; other site 926562001033 phosphorylation site [posttranslational modification] 926562001034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562001035 ATP binding site [chemical binding]; other site 926562001036 Mg2+ binding site [ion binding]; other site 926562001037 G-X-G motif; other site 926562001038 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926562001039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562001040 active site 926562001041 phosphorylation site [posttranslational modification] 926562001042 intermolecular recognition site; other site 926562001043 dimerization interface [polypeptide binding]; other site 926562001044 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 926562001045 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 926562001046 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926562001047 catalytic residues [active] 926562001048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926562001049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 926562001050 cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662 926562001051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926562001052 NAD(P) binding site [chemical binding]; other site 926562001053 active site 926562001054 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 926562001055 catalytic residues [active] 926562001056 dimer interface [polypeptide binding]; other site 926562001057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926562001058 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 926562001059 NAD(P) binding site [chemical binding]; other site 926562001060 active site 926562001061 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 926562001062 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 926562001063 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 926562001064 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 926562001065 classical (c) SDRs; Region: SDR_c; cd05233 926562001066 NAD(P) binding site [chemical binding]; other site 926562001067 active site 926562001068 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926562001069 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 926562001070 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926562001071 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 926562001072 E3 interaction surface; other site 926562001073 lipoyl attachment site [posttranslational modification]; other site 926562001074 HlyD family secretion protein; Region: HlyD_3; pfam13437 926562001075 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 926562001076 MarR family; Region: MarR_2; cl17246 926562001077 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 926562001078 active site 926562001079 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926562001080 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562001081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562001082 binding surface 926562001083 TPR motif; other site 926562001084 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562001085 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562001086 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562001087 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562001088 binding surface 926562001089 TPR motif; other site 926562001090 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562001091 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 926562001092 cyclase homology domain; Region: CHD; cd07302 926562001093 nucleotidyl binding site; other site 926562001094 metal binding site [ion binding]; metal-binding site 926562001095 dimer interface [polypeptide binding]; other site 926562001096 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 926562001097 putative active site [active] 926562001098 putative catalytic triad [active] 926562001099 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 926562001100 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562001101 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 926562001102 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 926562001103 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 926562001104 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 926562001105 active site 926562001106 dimer interface [polypeptide binding]; other site 926562001107 effector binding site; other site 926562001108 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 926562001109 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 926562001110 Protein of unknown function DUF58; Region: DUF58; pfam01882 926562001111 MoxR-like ATPases [General function prediction only]; Region: COG0714 926562001112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562001113 Walker A motif; other site 926562001114 ATP binding site [chemical binding]; other site 926562001115 Walker B motif; other site 926562001116 arginine finger; other site 926562001117 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 926562001118 Integral membrane protein DUF95; Region: DUF95; pfam01944 926562001119 RDD family; Region: RDD; pfam06271 926562001120 RDD family; Region: RDD; pfam06271 926562001121 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926562001122 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926562001123 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562001124 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 926562001125 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926562001126 dimerization interface [polypeptide binding]; other site 926562001127 putative DNA binding site [nucleotide binding]; other site 926562001128 putative Zn2+ binding site [ion binding]; other site 926562001129 MerT mercuric transport protein; Region: MerT; cl03578 926562001130 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 926562001131 metal-binding site [ion binding] 926562001132 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562001133 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562001134 dimer interface [polypeptide binding]; other site 926562001135 phosphorylation site [posttranslational modification] 926562001136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562001137 ATP binding site [chemical binding]; other site 926562001138 Mg2+ binding site [ion binding]; other site 926562001139 G-X-G motif; other site 926562001140 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926562001141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562001142 active site 926562001143 phosphorylation site [posttranslational modification] 926562001144 intermolecular recognition site; other site 926562001145 dimerization interface [polypeptide binding]; other site 926562001146 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926562001147 DNA binding site [nucleotide binding] 926562001148 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 926562001149 Methyltransferase domain; Region: Methyltransf_26; pfam13659 926562001150 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 926562001151 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 926562001152 metal-binding site [ion binding] 926562001153 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 926562001154 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562001155 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 926562001156 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 926562001157 cytochrome c-550; Provisional; Region: psbV; cl17239 926562001158 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 926562001159 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 926562001160 Outer membrane efflux protein; Region: OEP; pfam02321 926562001161 Outer membrane efflux protein; Region: OEP; pfam02321 926562001162 Domain of unknown function (DUF305); Region: DUF305; cl17794 926562001163 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 926562001164 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 926562001165 Soluble P-type ATPase [General function prediction only]; Region: COG4087 926562001166 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926562001167 HlyD family secretion protein; Region: HlyD_3; pfam13437 926562001168 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 926562001169 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 926562001170 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 926562001171 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926562001172 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 926562001173 Int/Topo IB signature motif; other site 926562001174 DNA binding site [nucleotide binding] 926562001175 shikimate kinase; Reviewed; Region: aroK; PRK00131 926562001176 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 926562001177 ADP binding site [chemical binding]; other site 926562001178 magnesium binding site [ion binding]; other site 926562001179 putative shikimate binding site; other site 926562001180 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 926562001181 putative FMN binding site [chemical binding]; other site 926562001182 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 926562001183 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 926562001184 transmembrane helices; other site 926562001185 Peptidase family M1; Region: Peptidase_M1; pfam01433 926562001186 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 926562001187 Zn binding site [ion binding]; other site 926562001188 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562001189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926562001190 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 926562001191 putative active site [active] 926562001192 heme pocket [chemical binding]; other site 926562001193 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926562001194 putative active site [active] 926562001195 heme pocket [chemical binding]; other site 926562001196 GAF domain; Region: GAF; cl17456 926562001197 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 926562001198 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926562001199 putative active site [active] 926562001200 heme pocket [chemical binding]; other site 926562001201 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562001202 dimer interface [polypeptide binding]; other site 926562001203 phosphorylation site [posttranslational modification] 926562001204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562001205 ATP binding site [chemical binding]; other site 926562001206 Mg2+ binding site [ion binding]; other site 926562001207 G-X-G motif; other site 926562001208 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 926562001209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562001210 active site 926562001211 phosphorylation site [posttranslational modification] 926562001212 intermolecular recognition site; other site 926562001213 dimerization interface [polypeptide binding]; other site 926562001214 LytTr DNA-binding domain; Region: LytTR; smart00850 926562001215 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 926562001216 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 926562001217 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 926562001218 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 926562001219 putative catalytic site [active] 926562001220 putative metal binding site [ion binding]; other site 926562001221 putative phosphate binding site [ion binding]; other site 926562001222 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 926562001223 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 926562001224 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 926562001225 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562001226 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 926562001227 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562001228 Predicted membrane protein [Function unknown]; Region: COG1470 926562001229 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 926562001230 metal binding site 2 [ion binding]; metal-binding site 926562001231 putative DNA binding helix; other site 926562001232 metal binding site 1 [ion binding]; metal-binding site 926562001233 dimer interface [polypeptide binding]; other site 926562001234 structural Zn2+ binding site [ion binding]; other site 926562001235 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562001236 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562001237 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562001238 Interdomain contacts; other site 926562001239 Cytokine receptor motif; other site 926562001240 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562001241 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562001242 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562001243 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562001244 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 926562001245 Methyltransferase domain; Region: Methyltransf_26; pfam13659 926562001246 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 926562001247 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 926562001248 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 926562001249 putative active site [active] 926562001250 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926562001251 Cupin domain; Region: Cupin_2; pfam07883 926562001252 Galactose oxidase, central domain; Region: Kelch_3; cl02701 926562001253 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 926562001254 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 926562001255 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562001256 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926562001257 Coenzyme A binding pocket [chemical binding]; other site 926562001258 CsbD-like; Region: CsbD; pfam05532 926562001259 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 926562001260 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 926562001261 active site 926562001262 DNA binding site [nucleotide binding] 926562001263 Int/Topo IB signature motif; other site 926562001264 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 926562001265 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 926562001266 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 926562001267 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 926562001268 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 926562001269 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926562001270 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926562001271 ligand binding site [chemical binding]; other site 926562001272 flexible hinge region; other site 926562001273 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 926562001274 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 926562001275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 926562001276 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 926562001277 Fic family protein [Function unknown]; Region: COG3177 926562001278 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 926562001279 Fic/DOC family; Region: Fic; pfam02661 926562001280 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 926562001281 putative DNA binding site [nucleotide binding]; other site 926562001282 putative Zn2+ binding site [ion binding]; other site 926562001283 DinB family; Region: DinB; cl17821 926562001284 DinB superfamily; Region: DinB_2; pfam12867 926562001285 Divergent AAA domain; Region: AAA_4; pfam04326 926562001286 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 926562001287 5' RNA guide strand anchoring site; other site 926562001288 active site 926562001289 TIR domain; Region: TIR_2; pfam13676 926562001290 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 926562001291 catalytic residues [active] 926562001292 Protein of unknown function (DUF808); Region: DUF808; cl01002 926562001293 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 926562001294 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 926562001295 trmE is a tRNA modification GTPase; Region: trmE; cd04164 926562001296 G1 box; other site 926562001297 GTP/Mg2+ binding site [chemical binding]; other site 926562001298 Switch I region; other site 926562001299 G2 box; other site 926562001300 Switch II region; other site 926562001301 G3 box; other site 926562001302 G4 box; other site 926562001303 G5 box; other site 926562001304 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 926562001305 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 926562001306 Ligand Binding Site [chemical binding]; other site 926562001307 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 926562001308 cyclase homology domain; Region: CHD; cd07302 926562001309 nucleotidyl binding site; other site 926562001310 metal binding site [ion binding]; metal-binding site 926562001311 dimer interface [polypeptide binding]; other site 926562001312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562001313 binding surface 926562001314 TPR motif; other site 926562001315 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 926562001316 cyclase homology domain; Region: CHD; cd07302 926562001317 nucleotidyl binding site; other site 926562001318 metal binding site [ion binding]; metal-binding site 926562001319 dimer interface [polypeptide binding]; other site 926562001320 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 926562001321 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 926562001322 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 926562001323 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 926562001324 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 926562001325 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 926562001326 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 926562001327 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 926562001328 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 926562001329 Domain of unknown function (DUF4294); Region: DUF4294; pfam14127 926562001330 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 926562001331 active site 926562001332 dinuclear metal binding site [ion binding]; other site 926562001333 dimerization interface [polypeptide binding]; other site 926562001334 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926562001335 active site 926562001336 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 926562001337 Fatty acid desaturase; Region: FA_desaturase; pfam00487 926562001338 Di-iron ligands [ion binding]; other site 926562001339 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562001340 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562001341 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 926562001342 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 926562001343 dimer interface [polypeptide binding]; other site 926562001344 active site 926562001345 CoA binding pocket [chemical binding]; other site 926562001346 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 926562001347 active site 926562001348 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 926562001349 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562001350 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 926562001351 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926562001352 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 926562001353 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 926562001354 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 926562001355 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 926562001356 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 926562001357 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562001358 Walker A motif; other site 926562001359 ATP binding site [chemical binding]; other site 926562001360 Walker B motif; other site 926562001361 arginine finger; other site 926562001362 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 926562001363 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 926562001364 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 926562001365 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 926562001366 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 926562001367 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 926562001368 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 926562001369 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 926562001370 Asp-box motif; other site 926562001371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926562001372 Major Facilitator Superfamily; Region: MFS_1; pfam07690 926562001373 putative substrate translocation pore; other site 926562001374 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 926562001375 Domain of unknown function DUF20; Region: UPF0118; pfam01594 926562001376 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 926562001377 active site clefts [active] 926562001378 zinc binding site [ion binding]; other site 926562001379 dimer interface [polypeptide binding]; other site 926562001380 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 926562001381 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 926562001382 Sulfate transporter family; Region: Sulfate_transp; pfam00916 926562001383 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926562001384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 926562001385 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 926562001386 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926562001387 Coenzyme A binding pocket [chemical binding]; other site 926562001388 FOG: CBS domain [General function prediction only]; Region: COG0517 926562001389 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 926562001390 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 926562001391 TrkA-N domain; Region: TrkA_N; pfam02254 926562001392 TrkA-C domain; Region: TrkA_C; pfam02080 926562001393 TrkA-N domain; Region: TrkA_N; pfam02254 926562001394 TrkA-C domain; Region: TrkA_C; pfam02080 926562001395 Cation transport protein; Region: TrkH; cl17365 926562001396 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 926562001397 transcription elongation factor regulatory protein; Validated; Region: PRK06342 926562001398 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 926562001399 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 926562001400 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 926562001401 FOG: PKD repeat [General function prediction only]; Region: COG3291 926562001402 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562001403 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562001404 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562001405 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926562001406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562001407 active site 926562001408 phosphorylation site [posttranslational modification] 926562001409 intermolecular recognition site; other site 926562001410 dimerization interface [polypeptide binding]; other site 926562001411 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926562001412 DNA binding residues [nucleotide binding] 926562001413 dimerization interface [polypeptide binding]; other site 926562001414 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 926562001415 Histidine kinase; Region: HisKA_3; pfam07730 926562001416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562001417 ATP binding site [chemical binding]; other site 926562001418 Mg2+ binding site [ion binding]; other site 926562001419 G-X-G motif; other site 926562001420 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 926562001421 active site 926562001422 Peptidase family M48; Region: Peptidase_M48; cl12018 926562001423 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562001424 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 926562001425 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562001426 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 926562001427 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 926562001428 Histidine kinase; Region: HisKA_3; pfam07730 926562001429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562001430 ATP binding site [chemical binding]; other site 926562001431 Mg2+ binding site [ion binding]; other site 926562001432 G-X-G motif; other site 926562001433 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926562001434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562001435 active site 926562001436 phosphorylation site [posttranslational modification] 926562001437 intermolecular recognition site; other site 926562001438 dimerization interface [polypeptide binding]; other site 926562001439 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926562001440 DNA binding residues [nucleotide binding] 926562001441 dimerization interface [polypeptide binding]; other site 926562001442 Kelch domain; Region: Kelch; smart00612 926562001443 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 926562001444 Kelch motif; Region: Kelch_1; pfam01344 926562001445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562001446 binding surface 926562001447 TPR motif; other site 926562001448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562001449 TPR motif; other site 926562001450 binding surface 926562001451 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 926562001452 30S subunit binding site; other site 926562001453 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 926562001454 metal binding site [ion binding]; metal-binding site 926562001455 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 926562001456 putative active site [active] 926562001457 Zn binding site [ion binding]; other site 926562001458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926562001459 non-specific DNA binding site [nucleotide binding]; other site 926562001460 salt bridge; other site 926562001461 sequence-specific DNA binding site [nucleotide binding]; other site 926562001462 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 926562001463 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 926562001464 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 926562001465 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 926562001466 active site pocket [active] 926562001467 putative dimer interface [polypeptide binding]; other site 926562001468 putative cataytic base [active] 926562001469 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 926562001470 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 926562001471 Walker A/P-loop; other site 926562001472 ATP binding site [chemical binding]; other site 926562001473 Q-loop/lid; other site 926562001474 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 926562001475 ABC transporter signature motif; other site 926562001476 Walker B; other site 926562001477 D-loop; other site 926562001478 H-loop/switch region; other site 926562001479 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 926562001480 Flavoprotein; Region: Flavoprotein; pfam02441 926562001481 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 926562001482 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 926562001483 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 926562001484 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 926562001485 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 926562001486 putative active site [active] 926562001487 putative metal binding site [ion binding]; other site 926562001488 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 926562001489 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 926562001490 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 926562001491 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 926562001492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562001493 TPR motif; other site 926562001494 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 926562001495 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 926562001496 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 926562001497 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 926562001498 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 926562001499 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 926562001500 homodimer interface [polypeptide binding]; other site 926562001501 substrate-cofactor binding pocket; other site 926562001502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562001503 catalytic residue [active] 926562001504 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 926562001505 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562001506 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562001507 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926562001508 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562001509 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 926562001510 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 926562001511 active site 926562001512 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 926562001513 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 926562001514 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 926562001515 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926562001516 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926562001517 catalytic residues [active] 926562001518 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 926562001519 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 926562001520 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 926562001521 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 926562001522 active site 926562001523 substrate binding site [chemical binding]; other site 926562001524 metal binding site [ion binding]; metal-binding site 926562001525 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 926562001526 hypothetical protein; Provisional; Region: PRK06753 926562001527 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 926562001528 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 926562001529 DEAD-like helicases superfamily; Region: DEXDc; smart00487 926562001530 ATP binding site [chemical binding]; other site 926562001531 Mg++ binding site [ion binding]; other site 926562001532 motif III; other site 926562001533 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926562001534 nucleotide binding region [chemical binding]; other site 926562001535 ATP-binding site [chemical binding]; other site 926562001536 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 926562001537 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 926562001538 hydrophobic ligand binding site; other site 926562001539 DEAD-like helicases superfamily; Region: DEXDc; smart00487 926562001540 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 926562001541 ATP binding site [chemical binding]; other site 926562001542 putative Mg++ binding site [ion binding]; other site 926562001543 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926562001544 nucleotide binding region [chemical binding]; other site 926562001545 ATP-binding site [chemical binding]; other site 926562001546 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 926562001547 RNA binding site [nucleotide binding]; other site 926562001548 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562001549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562001550 dimer interface [polypeptide binding]; other site 926562001551 phosphorylation site [posttranslational modification] 926562001552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562001553 ATP binding site [chemical binding]; other site 926562001554 Mg2+ binding site [ion binding]; other site 926562001555 G-X-G motif; other site 926562001556 heat shock protein 90; Provisional; Region: PRK05218 926562001557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562001558 ATP binding site [chemical binding]; other site 926562001559 Mg2+ binding site [ion binding]; other site 926562001560 G-X-G motif; other site 926562001561 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926562001562 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926562001563 Pirin-related protein [General function prediction only]; Region: COG1741 926562001564 Pirin; Region: Pirin; pfam02678 926562001565 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 926562001566 SdpI/YhfL protein family; Region: SdpI; pfam13630 926562001567 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 926562001568 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 926562001569 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926562001570 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926562001571 DNA binding residues [nucleotide binding] 926562001572 YHYH protein; Region: YHYH; pfam14240 926562001573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 926562001574 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 926562001575 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 926562001576 Cu(I) binding site [ion binding]; other site 926562001577 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 926562001578 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 926562001579 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 926562001580 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926562001581 ATP binding site [chemical binding]; other site 926562001582 putative Mg++ binding site [ion binding]; other site 926562001583 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926562001584 nucleotide binding region [chemical binding]; other site 926562001585 ATP-binding site [chemical binding]; other site 926562001586 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 926562001587 putative active site [active] 926562001588 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 926562001589 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 926562001590 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 926562001591 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 926562001592 RNA binding site [nucleotide binding]; other site 926562001593 Cytochrome c; Region: Cytochrom_C; pfam00034 926562001594 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 926562001595 Haem-binding domain; Region: Haem_bd; pfam14376 926562001596 Haem-binding domain; Region: Haem_bd; pfam14376 926562001597 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 926562001598 S1 domain; Region: S1_2; pfam13509 926562001599 Phosphopantetheine attachment site; Region: PP-binding; cl09936 926562001600 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 926562001601 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 926562001602 dimer interface [polypeptide binding]; other site 926562001603 active site 926562001604 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 926562001605 active site 2 [active] 926562001606 active site 1 [active] 926562001607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926562001608 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 926562001609 NAD(P) binding site [chemical binding]; other site 926562001610 active site 926562001611 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 926562001612 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 926562001613 malonyl-CoA binding site [chemical binding]; other site 926562001614 dimer interface [polypeptide binding]; other site 926562001615 active site 926562001616 product binding site; other site 926562001617 Methyltransferase domain; Region: Methyltransf_31; pfam13847 926562001618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562001619 S-adenosylmethionine binding site [chemical binding]; other site 926562001620 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 926562001621 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 926562001622 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 926562001623 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926562001624 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926562001625 ABC transporter; Region: ABC_tran_2; pfam12848 926562001626 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926562001627 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 926562001628 Protease prsW family; Region: PrsW-protease; pfam13367 926562001629 helicase 45; Provisional; Region: PTZ00424 926562001630 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 926562001631 ATP binding site [chemical binding]; other site 926562001632 Mg++ binding site [ion binding]; other site 926562001633 motif III; other site 926562001634 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926562001635 nucleotide binding region [chemical binding]; other site 926562001636 ATP-binding site [chemical binding]; other site 926562001637 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 926562001638 RNA binding site [nucleotide binding]; other site 926562001639 Protein of unknown function, DUF393; Region: DUF393; cl01136 926562001640 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 926562001641 NADH(P)-binding; Region: NAD_binding_10; pfam13460 926562001642 NAD(P) binding site [chemical binding]; other site 926562001643 putative active site [active] 926562001644 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 926562001645 active site 926562001646 catalytic residues [active] 926562001647 metal binding site [ion binding]; metal-binding site 926562001648 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 926562001649 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 926562001650 metal binding site [ion binding]; metal-binding site 926562001651 dimer interface [polypeptide binding]; other site 926562001652 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 926562001653 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 926562001654 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 926562001655 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 926562001656 NAD(P) binding site [chemical binding]; other site 926562001657 homotetramer interface [polypeptide binding]; other site 926562001658 homodimer interface [polypeptide binding]; other site 926562001659 active site 926562001660 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562001661 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 926562001662 SnoaL-like domain; Region: SnoaL_2; pfam12680 926562001663 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926562001664 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 926562001665 active site 926562001666 Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632 926562001667 putative inhibitory loop; other site 926562001668 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 926562001669 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 926562001670 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 926562001671 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 926562001672 active site 926562001673 HIGH motif; other site 926562001674 nucleotide binding site [chemical binding]; other site 926562001675 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 926562001676 KMSK motif region; other site 926562001677 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 926562001678 tRNA binding surface [nucleotide binding]; other site 926562001679 anticodon binding site; other site 926562001680 Arginase family; Region: Arginase; cd09989 926562001681 active site 926562001682 Mn binding site [ion binding]; other site 926562001683 oligomer interface [polypeptide binding]; other site 926562001684 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562001685 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 926562001686 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562001687 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 926562001688 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562001689 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562001690 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 926562001691 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 926562001692 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 926562001693 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 926562001694 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 926562001695 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 926562001696 Predicted permeases [General function prediction only]; Region: COG0795 926562001697 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 926562001698 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 926562001699 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 926562001700 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 926562001701 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926562001702 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 926562001703 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 926562001704 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 926562001705 DXD motif; other site 926562001706 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 926562001707 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 926562001708 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 926562001709 dimerization interface [polypeptide binding]; other site 926562001710 active site 926562001711 Family of unknown function (DUF490); Region: DUF490; pfam04357 926562001712 UGMP family protein; Validated; Region: PRK09604 926562001713 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 926562001714 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 926562001715 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 926562001716 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 926562001717 ATP-grasp domain; Region: ATP-grasp_4; cl17255 926562001718 RNA methyltransferase, RsmE family; Region: TIGR00046 926562001719 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 926562001720 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 926562001721 Transposase; Region: DEDD_Tnp_IS110; pfam01548 926562001722 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 926562001723 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 926562001724 triacylglycerol lipase; Region: PLN02872 926562001725 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 926562001726 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 926562001727 active site 926562001728 nucleophile elbow; other site 926562001729 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 926562001730 4Fe-4S binding domain; Region: Fer4_6; pfam12837 926562001731 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 926562001732 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 926562001733 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 926562001734 glutaminase; Provisional; Region: PRK00971 926562001735 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 926562001736 putative catalytic site [active] 926562001737 putative metal binding site [ion binding]; other site 926562001738 putative phosphate binding site [ion binding]; other site 926562001739 META domain; Region: META; pfam03724 926562001740 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926562001741 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926562001742 ligand binding site [chemical binding]; other site 926562001743 flexible hinge region; other site 926562001744 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 926562001745 putative hydrophobic ligand binding site [chemical binding]; other site 926562001746 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 926562001747 Coenzyme A binding pocket [chemical binding]; other site 926562001748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 926562001749 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 926562001750 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 926562001751 dihydrodipicolinate synthase; Region: dapA; TIGR00674 926562001752 dimer interface [polypeptide binding]; other site 926562001753 active site 926562001754 catalytic residue [active] 926562001755 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 926562001756 GIY-YIG motif/motif A; other site 926562001757 putative active site [active] 926562001758 putative metal binding site [ion binding]; other site 926562001759 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 926562001760 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 926562001761 nucleotide binding pocket [chemical binding]; other site 926562001762 K-X-D-G motif; other site 926562001763 catalytic site [active] 926562001764 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 926562001765 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 926562001766 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 926562001767 Dimer interface [polypeptide binding]; other site 926562001768 BRCT sequence motif; other site 926562001769 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 926562001770 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 926562001771 DinB superfamily; Region: DinB_2; pfam12867 926562001772 metal-dependent hydrolase; Provisional; Region: PRK13291 926562001773 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 926562001774 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926562001775 NRDE protein; Region: NRDE; cl01315 926562001776 Predicted transcriptional regulators [Transcription]; Region: COG1695 926562001777 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 926562001778 PspC domain; Region: PspC; pfam04024 926562001779 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 926562001780 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 926562001781 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926562001782 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 926562001783 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926562001784 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926562001785 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926562001786 DNA binding residues [nucleotide binding] 926562001787 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 926562001788 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 926562001789 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 926562001790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926562001791 Walker A/P-loop; other site 926562001792 ATP binding site [chemical binding]; other site 926562001793 Q-loop/lid; other site 926562001794 ABC transporter signature motif; other site 926562001795 Walker B; other site 926562001796 D-loop; other site 926562001797 H-loop/switch region; other site 926562001798 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926562001799 ligand binding site [chemical binding]; other site 926562001800 Restriction endonuclease; Region: Mrr_cat; pfam04471 926562001801 Bacterial Ig-like domain; Region: Big_5; pfam13205 926562001802 Major royal jelly protein; Region: MRJP; pfam03022 926562001803 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926562001804 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 926562001805 active site 926562001806 metal binding site [ion binding]; metal-binding site 926562001807 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 926562001808 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 926562001809 active site 926562001810 Peptidase family M49; Region: Peptidase_M49; pfam03571 926562001811 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562001812 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 926562001813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 926562001814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 926562001815 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926562001816 active site 926562001817 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 926562001818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926562001819 PAS domain; Region: PAS_9; pfam13426 926562001820 putative active site [active] 926562001821 heme pocket [chemical binding]; other site 926562001822 PAS fold; Region: PAS_3; pfam08447 926562001823 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562001824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562001825 ATP binding site [chemical binding]; other site 926562001826 Mg2+ binding site [ion binding]; other site 926562001827 G-X-G motif; other site 926562001828 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 926562001829 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 926562001830 beta-carotene hydroxylase; Region: PLN02601 926562001831 Protein of unknown function (DUF422); Region: DUF422; cl00991 926562001832 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 926562001833 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 926562001834 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926562001835 FeS/SAM binding site; other site 926562001836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 926562001837 Methyltransferase domain; Region: Methyltransf_23; pfam13489 926562001838 Predicted membrane protein [Function unknown]; Region: COG2860 926562001839 UPF0126 domain; Region: UPF0126; pfam03458 926562001840 UPF0126 domain; Region: UPF0126; pfam03458 926562001841 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 926562001842 CoA binding domain; Region: CoA_binding; smart00881 926562001843 CoA-ligase; Region: Ligase_CoA; pfam00549 926562001844 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 926562001845 putative FMN binding site [chemical binding]; other site 926562001846 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 926562001847 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 926562001848 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 926562001849 CsbD-like; Region: CsbD; pfam05532 926562001850 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 926562001851 CoenzymeA binding site [chemical binding]; other site 926562001852 subunit interaction site [polypeptide binding]; other site 926562001853 PHB binding site; other site 926562001854 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 926562001855 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 926562001856 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 926562001857 Sulfate transporter family; Region: Sulfate_transp; pfam00916 926562001858 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 926562001859 helicase 45; Provisional; Region: PTZ00424 926562001860 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 926562001861 ATP binding site [chemical binding]; other site 926562001862 Mg++ binding site [ion binding]; other site 926562001863 motif III; other site 926562001864 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926562001865 nucleotide binding region [chemical binding]; other site 926562001866 ATP-binding site [chemical binding]; other site 926562001867 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 926562001868 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 926562001869 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926562001870 catalytic residue [active] 926562001871 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 926562001872 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 926562001873 substrate binding pocket [chemical binding]; other site 926562001874 membrane-bound complex binding site; other site 926562001875 hinge residues; other site 926562001876 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 926562001877 N-acetyl-D-glucosamine binding site [chemical binding]; other site 926562001878 catalytic residue [active] 926562001879 TIGR01666 family membrane protein; Region: YCCS 926562001880 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 926562001881 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 926562001882 RNA polymerase sigma-K factor; Region: spore_sigmaK; TIGR02846 926562001883 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 926562001884 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562001885 SHNi-TPR; Region: SHNi-TPR; pfam10516 926562001886 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562001887 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562001888 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562001889 TPR motif; other site 926562001890 binding surface 926562001891 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562001892 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562001893 dimer interface [polypeptide binding]; other site 926562001894 phosphorylation site [posttranslational modification] 926562001895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562001896 ATP binding site [chemical binding]; other site 926562001897 Mg2+ binding site [ion binding]; other site 926562001898 G-X-G motif; other site 926562001899 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926562001900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562001901 active site 926562001902 phosphorylation site [posttranslational modification] 926562001903 intermolecular recognition site; other site 926562001904 dimerization interface [polypeptide binding]; other site 926562001905 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 926562001906 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 926562001907 CoA-ligase; Region: Ligase_CoA; pfam00549 926562001908 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926562001909 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926562001910 Walker A/P-loop; other site 926562001911 ATP binding site [chemical binding]; other site 926562001912 Q-loop/lid; other site 926562001913 ABC transporter signature motif; other site 926562001914 Walker B; other site 926562001915 D-loop; other site 926562001916 H-loop/switch region; other site 926562001917 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 926562001918 putative active site [active] 926562001919 FG-GAP repeat; Region: FG-GAP_2; pfam14312 926562001920 FG-GAP repeat; Region: FG-GAP_2; pfam14312 926562001921 FG-GAP repeat; Region: FG-GAP_2; pfam14312 926562001922 FG-GAP repeat; Region: FG-GAP_2; pfam14312 926562001923 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562001924 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 926562001925 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 926562001926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926562001927 active site 926562001928 motif I; other site 926562001929 motif II; other site 926562001930 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562001931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926562001932 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 926562001933 NAD(P) binding site [chemical binding]; other site 926562001934 active site 926562001935 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 926562001936 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926562001937 FeS/SAM binding site; other site 926562001938 OsmC-like protein; Region: OsmC; pfam02566 926562001939 hypothetical protein; Provisional; Region: PRK12378 926562001940 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 926562001941 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 926562001942 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 926562001943 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 926562001944 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 926562001945 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 926562001946 transmembrane helices; other site 926562001947 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 926562001948 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 926562001949 DNA gyrase subunit A; Validated; Region: PRK05560 926562001950 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 926562001951 CAP-like domain; other site 926562001952 active site 926562001953 primary dimer interface [polypeptide binding]; other site 926562001954 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 926562001955 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 926562001956 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 926562001957 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 926562001958 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 926562001959 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 926562001960 Clp amino terminal domain; Region: Clp_N; pfam02861 926562001961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562001962 Walker A motif; other site 926562001963 ATP binding site [chemical binding]; other site 926562001964 Walker B motif; other site 926562001965 arginine finger; other site 926562001966 UvrB/uvrC motif; Region: UVR; pfam02151 926562001967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562001968 Walker A motif; other site 926562001969 ATP binding site [chemical binding]; other site 926562001970 Walker B motif; other site 926562001971 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 926562001972 Integrase core domain; Region: rve; pfam00665 926562001973 Integrase core domain; Region: rve_3; pfam13683 926562001974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 926562001975 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562001976 PAS fold; Region: PAS_3; pfam08447 926562001977 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926562001978 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926562001979 DNA binding residues [nucleotide binding] 926562001980 dimerization interface [polypeptide binding]; other site 926562001981 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 926562001982 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562001983 Interdomain contacts; other site 926562001984 Cytokine receptor motif; other site 926562001985 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562001986 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562001987 Interdomain contacts; other site 926562001988 Cytokine receptor motif; other site 926562001989 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562001990 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562001991 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 926562001992 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562001993 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 926562001994 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562001995 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562001996 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562001997 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562001998 Interdomain contacts; other site 926562001999 Cytokine receptor motif; other site 926562002000 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 926562002001 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 926562002002 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562002003 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562002004 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562002005 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562002006 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562002007 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562002008 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562002009 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562002010 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562002011 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562002012 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562002013 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 926562002014 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 926562002015 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 926562002016 FOG: PKD repeat [General function prediction only]; Region: COG3291 926562002017 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562002018 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562002019 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 926562002020 active sites [active] 926562002021 tetramer interface [polypeptide binding]; other site 926562002022 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 926562002023 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 926562002024 dimer interface [polypeptide binding]; other site 926562002025 motif 1; other site 926562002026 active site 926562002027 motif 2; other site 926562002028 motif 3; other site 926562002029 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 926562002030 anticodon binding site; other site 926562002031 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926562002032 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926562002033 active site 926562002034 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 926562002035 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 926562002036 Ligand binding site; other site 926562002037 Putative Catalytic site; other site 926562002038 DXD motif; other site 926562002039 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 926562002040 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562002041 TPR repeat; Region: TPR_11; pfam13414 926562002042 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562002043 binding surface 926562002044 TPR motif; other site 926562002045 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562002046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562002047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562002048 ATP binding site [chemical binding]; other site 926562002049 Mg2+ binding site [ion binding]; other site 926562002050 G-X-G motif; other site 926562002051 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 926562002052 active site 926562002053 intersubunit interactions; other site 926562002054 catalytic residue [active] 926562002055 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 926562002056 putative carbohydrate kinase; Provisional; Region: PRK10565 926562002057 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 926562002058 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 926562002059 putative substrate binding site [chemical binding]; other site 926562002060 putative ATP binding site [chemical binding]; other site 926562002061 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 926562002062 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 926562002063 CoA-binding site [chemical binding]; other site 926562002064 ATP-binding [chemical binding]; other site 926562002065 Preprotein translocase subunit; Region: YajC; pfam02699 926562002066 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 926562002067 transcription antitermination factor NusB; Region: nusB; TIGR01951 926562002068 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 926562002069 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 926562002070 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 926562002071 NAD binding site [chemical binding]; other site 926562002072 Phe binding site; other site 926562002073 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 926562002074 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926562002075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926562002076 Walker A/P-loop; other site 926562002077 ATP binding site [chemical binding]; other site 926562002078 Q-loop/lid; other site 926562002079 ABC transporter signature motif; other site 926562002080 Walker B; other site 926562002081 D-loop; other site 926562002082 H-loop/switch region; other site 926562002083 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 926562002084 imidazolonepropionase; Validated; Region: PRK09356 926562002085 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 926562002086 active site 926562002087 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 926562002088 active site 926562002089 metal binding site [ion binding]; metal-binding site 926562002090 P-loop containing region of AAA domain; Region: AAA_29; cl17516 926562002091 AAA domain; Region: AAA_21; pfam13304 926562002092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926562002093 Q-loop/lid; other site 926562002094 ABC transporter signature motif; other site 926562002095 Walker B; other site 926562002096 D-loop; other site 926562002097 H-loop/switch region; other site 926562002098 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 926562002099 Formiminotransferase domain; Region: FTCD; pfam02971 926562002100 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 926562002101 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926562002102 Peptide-N-glycosidase F, N terminal; Region: N-glycanase_N; pfam09112 926562002103 Peptide-N-glycosidase F, C terminal; Region: N-glycanase_C; pfam09113 926562002104 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562002105 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 926562002106 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 926562002107 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 926562002108 dimer interface [polypeptide binding]; other site 926562002109 active site 926562002110 Phosphopantetheine attachment site; Region: PP-binding; cl09936 926562002111 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 926562002112 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 926562002113 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 926562002114 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 926562002115 Walker A/P-loop; other site 926562002116 ATP binding site [chemical binding]; other site 926562002117 Q-loop/lid; other site 926562002118 ABC transporter signature motif; other site 926562002119 Walker B; other site 926562002120 D-loop; other site 926562002121 H-loop/switch region; other site 926562002122 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 926562002123 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 926562002124 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 926562002125 dimer interface [polypeptide binding]; other site 926562002126 active site 926562002127 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 926562002128 intracellular protease, PfpI family; Region: PfpI; TIGR01382 926562002129 proposed catalytic triad [active] 926562002130 conserved cys residue [active] 926562002131 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 926562002132 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 926562002133 Ligand binding site; other site 926562002134 oligomer interface; other site 926562002135 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 926562002136 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 926562002137 NADH(P)-binding; Region: NAD_binding_10; pfam13460 926562002138 NAD binding site [chemical binding]; other site 926562002139 active site 926562002140 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 926562002141 recombination factor protein RarA; Reviewed; Region: PRK13342 926562002142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562002143 Walker A motif; other site 926562002144 ATP binding site [chemical binding]; other site 926562002145 Walker B motif; other site 926562002146 arginine finger; other site 926562002147 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 926562002148 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 926562002149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 926562002150 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926562002151 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926562002152 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 926562002153 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 926562002154 Bacterial sugar transferase; Region: Bac_transf; pfam02397 926562002155 Flagellin N-methylase; Region: FliB; pfam03692 926562002156 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 926562002157 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 926562002158 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 926562002159 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 926562002160 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926562002161 FtsX-like permease family; Region: FtsX; pfam02687 926562002162 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 926562002163 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 926562002164 dimer interface [polypeptide binding]; other site 926562002165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562002166 catalytic residue [active] 926562002167 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 926562002168 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 926562002169 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 926562002170 cobalamin binding residues [chemical binding]; other site 926562002171 putative BtuC binding residues; other site 926562002172 dimer interface [polypeptide binding]; other site 926562002173 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 926562002174 GIY-YIG motif/motif A; other site 926562002175 putative active site [active] 926562002176 putative metal binding site [ion binding]; other site 926562002177 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 926562002178 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 926562002179 quinone interaction residues [chemical binding]; other site 926562002180 active site 926562002181 catalytic residues [active] 926562002182 FMN binding site [chemical binding]; other site 926562002183 substrate binding site [chemical binding]; other site 926562002184 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 926562002185 SmpB-tmRNA interface; other site 926562002186 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 926562002187 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 926562002188 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 926562002189 homodimer interface [polypeptide binding]; other site 926562002190 NADP binding site [chemical binding]; other site 926562002191 substrate binding site [chemical binding]; other site 926562002192 signal recognition particle protein; Provisional; Region: PRK10867 926562002193 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 926562002194 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 926562002195 P loop; other site 926562002196 GTP binding site [chemical binding]; other site 926562002197 Signal peptide binding domain; Region: SRP_SPB; pfam02978 926562002198 PemK-like protein; Region: PemK; pfam02452 926562002199 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 926562002200 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562002201 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 926562002202 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 926562002203 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 926562002204 dimer interface [polypeptide binding]; other site 926562002205 active site 926562002206 glycine-pyridoxal phosphate binding site [chemical binding]; other site 926562002207 folate binding site [chemical binding]; other site 926562002208 fumarylacetoacetase; Region: PLN02856 926562002209 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 926562002210 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 926562002211 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 926562002212 Response regulator receiver domain; Region: Response_reg; pfam00072 926562002213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562002214 active site 926562002215 phosphorylation site [posttranslational modification] 926562002216 intermolecular recognition site; other site 926562002217 dimerization interface [polypeptide binding]; other site 926562002218 PAS domain S-box; Region: sensory_box; TIGR00229 926562002219 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926562002220 putative active site [active] 926562002221 heme pocket [chemical binding]; other site 926562002222 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562002223 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 926562002224 phosphorylation site [posttranslational modification] 926562002225 dimer interface [polypeptide binding]; other site 926562002226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562002227 ATP binding site [chemical binding]; other site 926562002228 Mg2+ binding site [ion binding]; other site 926562002229 G-X-G motif; other site 926562002230 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 926562002231 pentamer interface [polypeptide binding]; other site 926562002232 dodecaamer interface [polypeptide binding]; other site 926562002233 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 926562002234 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562002235 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562002236 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 926562002237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926562002238 Walker A/P-loop; other site 926562002239 ATP binding site [chemical binding]; other site 926562002240 Q-loop/lid; other site 926562002241 ABC transporter signature motif; other site 926562002242 Walker B; other site 926562002243 D-loop; other site 926562002244 H-loop/switch region; other site 926562002245 ABC transporter; Region: ABC_tran_2; pfam12848 926562002246 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926562002247 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562002248 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 926562002249 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 926562002250 catalytic motif [active] 926562002251 Zn binding site [ion binding]; other site 926562002252 RibD C-terminal domain; Region: RibD_C; cl17279 926562002253 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 926562002254 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 926562002255 Zn binding site [ion binding]; other site 926562002256 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562002257 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 926562002258 active site 926562002259 DnaA N-terminal domain; Region: DnaA_N; pfam11638 926562002260 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 926562002261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562002262 Walker A motif; other site 926562002263 ATP binding site [chemical binding]; other site 926562002264 Walker B motif; other site 926562002265 arginine finger; other site 926562002266 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 926562002267 DnaA box-binding interface [nucleotide binding]; other site 926562002268 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 926562002269 Low molecular weight phosphatase family; Region: LMWPc; cd00115 926562002270 active site 926562002271 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 926562002272 putative SAM binding site [chemical binding]; other site 926562002273 homodimer interface [polypeptide binding]; other site 926562002274 Peptidase S46; Region: Peptidase_S46; pfam10459 926562002275 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562002276 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562002277 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562002278 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562002279 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562002280 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562002281 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 926562002282 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562002283 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 926562002284 DNA-binding site [nucleotide binding]; DNA binding site 926562002285 RNA-binding motif; other site 926562002286 Domain of unknown function (DUF427); Region: DUF427; pfam04248 926562002287 Response regulator receiver domain; Region: Response_reg; pfam00072 926562002288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562002289 active site 926562002290 phosphorylation site [posttranslational modification] 926562002291 intermolecular recognition site; other site 926562002292 dimerization interface [polypeptide binding]; other site 926562002293 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562002294 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 926562002295 dimer interface [polypeptide binding]; other site 926562002296 phosphorylation site [posttranslational modification] 926562002297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562002298 ATP binding site [chemical binding]; other site 926562002299 Mg2+ binding site [ion binding]; other site 926562002300 G-X-G motif; other site 926562002301 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 926562002302 tetramer interface [polypeptide binding]; other site 926562002303 TPP-binding site [chemical binding]; other site 926562002304 heterodimer interface [polypeptide binding]; other site 926562002305 phosphorylation loop region [posttranslational modification] 926562002306 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 926562002307 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 926562002308 PYR/PP interface [polypeptide binding]; other site 926562002309 dimer interface [polypeptide binding]; other site 926562002310 TPP binding site [chemical binding]; other site 926562002311 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 926562002312 16S rRNA methyltransferase B; Provisional; Region: PRK14901 926562002313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562002314 S-adenosylmethionine binding site [chemical binding]; other site 926562002315 PIN domain; Region: PIN_3; cl17397 926562002316 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 926562002317 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 926562002318 putative active site [active] 926562002319 Predicted esterase [General function prediction only]; Region: COG0400 926562002320 putative hydrolase; Provisional; Region: PRK11460 926562002321 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 926562002322 nudix motif; other site 926562002323 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926562002324 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 926562002325 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 926562002326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562002327 active site 926562002328 phosphorylation site [posttranslational modification] 926562002329 intermolecular recognition site; other site 926562002330 dimerization interface [polypeptide binding]; other site 926562002331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562002332 Walker A motif; other site 926562002333 ATP binding site [chemical binding]; other site 926562002334 Walker B motif; other site 926562002335 arginine finger; other site 926562002336 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 926562002337 CHASE3 domain; Region: CHASE3; pfam05227 926562002338 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562002339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562002340 dimer interface [polypeptide binding]; other site 926562002341 phosphorylation site [posttranslational modification] 926562002342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562002343 ATP binding site [chemical binding]; other site 926562002344 Mg2+ binding site [ion binding]; other site 926562002345 G-X-G motif; other site 926562002346 Response regulator receiver domain; Region: Response_reg; pfam00072 926562002347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562002348 active site 926562002349 phosphorylation site [posttranslational modification] 926562002350 intermolecular recognition site; other site 926562002351 dimerization interface [polypeptide binding]; other site 926562002352 Hpt domain; Region: Hpt; pfam01627 926562002353 histidine decarboxylase; Provisional; Region: PRK02769 926562002354 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926562002355 catalytic residue [active] 926562002356 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 926562002357 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 926562002358 AsnC family; Region: AsnC_trans_reg; pfam01037 926562002359 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 926562002360 metal ion-dependent adhesion site (MIDAS); other site 926562002361 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 926562002362 Integrase core domain; Region: rve; pfam00665 926562002363 Integrase core domain; Region: rve_3; pfam13683 926562002364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 926562002365 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 926562002366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562002367 S-adenosylmethionine binding site [chemical binding]; other site 926562002368 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 926562002369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926562002370 NAD(P) binding site [chemical binding]; other site 926562002371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926562002372 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 926562002373 active site 926562002374 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 926562002375 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 926562002376 dimer interface [polypeptide binding]; other site 926562002377 active site 926562002378 metal binding site [ion binding]; metal-binding site 926562002379 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926562002380 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 926562002381 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926562002382 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926562002383 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926562002384 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926562002385 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 926562002386 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 926562002387 ligand binding site [chemical binding]; other site 926562002388 GMP synthase; Reviewed; Region: guaA; PRK00074 926562002389 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 926562002390 AMP/PPi binding site [chemical binding]; other site 926562002391 candidate oxyanion hole; other site 926562002392 catalytic triad [active] 926562002393 potential glutamine specificity residues [chemical binding]; other site 926562002394 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 926562002395 ATP Binding subdomain [chemical binding]; other site 926562002396 Ligand Binding sites [chemical binding]; other site 926562002397 Dimerization subdomain; other site 926562002398 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 926562002399 putative hydrophobic ligand binding site [chemical binding]; other site 926562002400 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 926562002401 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 926562002402 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 926562002403 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 926562002404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 926562002405 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 926562002406 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 926562002407 DHHW protein; Region: DHHW; pfam14286 926562002408 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 926562002409 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 926562002410 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 926562002411 Na binding site [ion binding]; other site 926562002412 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 926562002413 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 926562002414 active site 926562002415 catalytic triad [active] 926562002416 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 926562002417 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 926562002418 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562002419 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 926562002420 Na binding site [ion binding]; other site 926562002421 recombination protein RecR; Reviewed; Region: recR; PRK00076 926562002422 RecR protein; Region: RecR; pfam02132 926562002423 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 926562002424 putative active site [active] 926562002425 putative metal-binding site [ion binding]; other site 926562002426 tetramer interface [polypeptide binding]; other site 926562002427 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926562002428 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 926562002429 Probable Catalytic site; other site 926562002430 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926562002431 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 926562002432 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 926562002433 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 926562002434 E3 interaction surface; other site 926562002435 lipoyl attachment site [posttranslational modification]; other site 926562002436 e3 binding domain; Region: E3_binding; pfam02817 926562002437 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 926562002438 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 926562002439 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 926562002440 active site 926562002441 catalytic site [active] 926562002442 substrate binding site [chemical binding]; other site 926562002443 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 926562002444 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 926562002445 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 926562002446 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562002447 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562002448 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 926562002449 Clp amino terminal domain; Region: Clp_N; pfam02861 926562002450 Clp amino terminal domain; Region: Clp_N; pfam02861 926562002451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562002452 Walker A motif; other site 926562002453 ATP binding site [chemical binding]; other site 926562002454 Walker B motif; other site 926562002455 arginine finger; other site 926562002456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562002457 Walker A motif; other site 926562002458 ATP binding site [chemical binding]; other site 926562002459 Walker B motif; other site 926562002460 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 926562002461 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562002462 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 926562002463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562002464 active site 926562002465 phosphorylation site [posttranslational modification] 926562002466 intermolecular recognition site; other site 926562002467 dimerization interface [polypeptide binding]; other site 926562002468 LytTr DNA-binding domain; Region: LytTR; pfam04397 926562002469 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562002470 binding surface 926562002471 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562002472 TPR motif; other site 926562002473 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562002474 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562002475 Histidine kinase; Region: His_kinase; pfam06580 926562002476 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 926562002477 ATP binding site [chemical binding]; other site 926562002478 Mg2+ binding site [ion binding]; other site 926562002479 G-X-G motif; other site 926562002480 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562002481 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926562002482 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574 926562002483 YceG-like family; Region: YceG; pfam02618 926562002484 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 926562002485 dimerization interface [polypeptide binding]; other site 926562002486 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 926562002487 TPR repeat; Region: TPR_11; pfam13414 926562002488 TPR repeat; Region: TPR_11; pfam13414 926562002489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562002490 TPR motif; other site 926562002491 TPR repeat; Region: TPR_11; pfam13414 926562002492 binding surface 926562002493 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 926562002494 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 926562002495 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 926562002496 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 926562002497 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 926562002498 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 926562002499 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 926562002500 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 926562002501 protein binding site [polypeptide binding]; other site 926562002502 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 926562002503 protein binding site [polypeptide binding]; other site 926562002504 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 926562002505 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 926562002506 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 926562002507 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 926562002508 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 926562002509 Response regulator receiver domain; Region: Response_reg; pfam00072 926562002510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562002511 active site 926562002512 phosphorylation site [posttranslational modification] 926562002513 intermolecular recognition site; other site 926562002514 dimerization interface [polypeptide binding]; other site 926562002515 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 926562002516 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926562002517 putative active site [active] 926562002518 heme pocket [chemical binding]; other site 926562002519 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 926562002520 active site 926562002521 dinuclear metal binding site [ion binding]; other site 926562002522 dimerization interface [polypeptide binding]; other site 926562002523 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 926562002524 Sulfate transporter family; Region: Sulfate_transp; pfam00916 926562002525 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 926562002526 Ligand Binding Site [chemical binding]; other site 926562002527 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 926562002528 Ligand Binding Site [chemical binding]; other site 926562002529 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 926562002530 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562002531 lipoyl synthase; Provisional; Region: PRK05481 926562002532 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926562002533 FeS/SAM binding site; other site 926562002534 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 926562002535 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 926562002536 ligand binding site [chemical binding]; other site 926562002537 active site 926562002538 UGI interface [polypeptide binding]; other site 926562002539 catalytic site [active] 926562002540 Surface antigen; Region: Bac_surface_Ag; pfam01103 926562002541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926562002542 active site 926562002543 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 926562002544 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 926562002545 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 926562002546 Peptidase family M1; Region: Peptidase_M1; pfam01433 926562002547 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 926562002548 Zn binding site [ion binding]; other site 926562002549 PKD domain; Region: PKD; pfam00801 926562002550 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562002551 Surface antigen; Region: Bac_surface_Ag; pfam01103 926562002552 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 926562002553 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 926562002554 active site 926562002555 HIGH motif; other site 926562002556 nucleotide binding site [chemical binding]; other site 926562002557 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 926562002558 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 926562002559 active site 926562002560 KMSKS motif; other site 926562002561 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 926562002562 tRNA binding surface [nucleotide binding]; other site 926562002563 anticodon binding site; other site 926562002564 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 926562002565 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 926562002566 aspartate aminotransferase; Provisional; Region: PRK07568 926562002567 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 926562002568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562002569 homodimer interface [polypeptide binding]; other site 926562002570 catalytic residue [active] 926562002571 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 926562002572 FAD binding domain; Region: FAD_binding_4; pfam01565 926562002573 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 926562002574 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926562002575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562002576 active site 926562002577 phosphorylation site [posttranslational modification] 926562002578 intermolecular recognition site; other site 926562002579 dimerization interface [polypeptide binding]; other site 926562002580 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926562002581 dimerization interface [polypeptide binding]; other site 926562002582 DNA binding residues [nucleotide binding] 926562002583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562002584 binding surface 926562002585 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562002586 TPR motif; other site 926562002587 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 926562002588 Histidine kinase; Region: HisKA_3; pfam07730 926562002589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562002590 ATP binding site [chemical binding]; other site 926562002591 Mg2+ binding site [ion binding]; other site 926562002592 G-X-G motif; other site 926562002593 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 926562002594 ApbE family; Region: ApbE; pfam02424 926562002595 Surface antigen; Region: Bac_surface_Ag; pfam01103 926562002596 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 926562002597 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 926562002598 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926562002599 Uncharacterized conserved protein [Function unknown]; Region: COG4850 926562002600 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 926562002601 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 926562002602 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 926562002603 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 926562002604 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 926562002605 Chorismate mutase type II; Region: CM_2; smart00830 926562002606 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 926562002607 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 926562002608 Zn binding site [ion binding]; other site 926562002609 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926562002610 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 926562002611 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 926562002612 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 926562002613 active site 926562002614 multimer interface [polypeptide binding]; other site 926562002615 Protein of unknown function (DUF721); Region: DUF721; pfam05258 926562002616 recombination protein F; Reviewed; Region: recF; PRK00064 926562002617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926562002618 Walker A/P-loop; other site 926562002619 ATP binding site [chemical binding]; other site 926562002620 Q-loop/lid; other site 926562002621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926562002622 ABC transporter signature motif; other site 926562002623 Walker B; other site 926562002624 D-loop; other site 926562002625 H-loop/switch region; other site 926562002626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 926562002627 binding surface 926562002628 TPR motif; other site 926562002629 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 926562002630 homopentamer interface [polypeptide binding]; other site 926562002631 active site 926562002632 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 926562002633 asparagine synthetase AsnA; Provisional; Region: PRK05425 926562002634 motif 1; other site 926562002635 dimer interface [polypeptide binding]; other site 926562002636 active site 926562002637 motif 2; other site 926562002638 motif 3; other site 926562002639 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 926562002640 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 926562002641 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 926562002642 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 926562002643 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 926562002644 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926562002645 FeS/SAM binding site; other site 926562002646 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 926562002647 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 926562002648 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 926562002649 Peptidase family M48; Region: Peptidase_M48; cl12018 926562002650 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 926562002651 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 926562002652 PhnA protein; Region: PhnA; pfam03831 926562002653 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 926562002654 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 926562002655 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562002656 dimer interface [polypeptide binding]; other site 926562002657 phosphorylation site [posttranslational modification] 926562002658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562002659 ATP binding site [chemical binding]; other site 926562002660 Mg2+ binding site [ion binding]; other site 926562002661 G-X-G motif; other site 926562002662 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 926562002663 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 926562002664 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926562002665 Zn2+ binding site [ion binding]; other site 926562002666 Mg2+ binding site [ion binding]; other site 926562002667 acetyl-CoA C-acetyltransferase; Region: PLN02644 926562002668 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 926562002669 dimer interface [polypeptide binding]; other site 926562002670 active site 926562002671 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 926562002672 NlpC/P60 family; Region: NLPC_P60; pfam00877 926562002673 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 926562002674 Catalytic site [active] 926562002675 KWG Leptospira; Region: KWG; pfam07656 926562002676 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 926562002677 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 926562002678 DEAD-like helicases superfamily; Region: DEXDc; smart00487 926562002679 ATP binding site [chemical binding]; other site 926562002680 Mg++ binding site [ion binding]; other site 926562002681 motif III; other site 926562002682 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926562002683 nucleotide binding region [chemical binding]; other site 926562002684 ATP-binding site [chemical binding]; other site 926562002685 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 926562002686 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 926562002687 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926562002688 ligand binding site [chemical binding]; other site 926562002689 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562002690 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926562002691 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 926562002692 N-terminal plug; other site 926562002693 ligand-binding site [chemical binding]; other site 926562002694 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 926562002695 N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211 926562002696 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 926562002697 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 926562002698 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 926562002699 putative acyl-acceptor binding pocket; other site 926562002700 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 926562002701 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 926562002702 Probable Catalytic site; other site 926562002703 metal-binding site 926562002704 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 926562002705 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 926562002706 ATP binding site [chemical binding]; other site 926562002707 Mg++ binding site [ion binding]; other site 926562002708 motif III; other site 926562002709 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926562002710 nucleotide binding region [chemical binding]; other site 926562002711 ATP-binding site [chemical binding]; other site 926562002712 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 926562002713 putative hydrophobic ligand binding site [chemical binding]; other site 926562002714 Dehydroquinase class II; Region: DHquinase_II; pfam01220 926562002715 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 926562002716 trimer interface [polypeptide binding]; other site 926562002717 active site 926562002718 dimer interface [polypeptide binding]; other site 926562002719 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 926562002720 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 926562002721 active site 926562002722 Int/Topo IB signature motif; other site 926562002723 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 926562002724 active site 926562002725 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 926562002726 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 926562002727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926562002728 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926562002729 active site 926562002730 Predicted membrane protein [Function unknown]; Region: COG2323 926562002731 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 926562002732 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 926562002733 Uncharacterized conserved protein [Function unknown]; Region: COG4095 926562002734 short chain dehydrogenase; Provisional; Region: PRK06701 926562002735 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 926562002736 NAD binding site [chemical binding]; other site 926562002737 metal binding site [ion binding]; metal-binding site 926562002738 active site 926562002739 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 926562002740 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 926562002741 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 926562002742 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 926562002743 [2Fe-2S] cluster binding site [ion binding]; other site 926562002744 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 926562002745 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 926562002746 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926562002747 FeS/SAM binding site; other site 926562002748 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 926562002749 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 926562002750 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 926562002751 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 926562002752 dimer interface [polypeptide binding]; other site 926562002753 active site 926562002754 heme binding site [chemical binding]; other site 926562002755 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 926562002756 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926562002757 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 926562002758 ligand binding site [chemical binding]; other site 926562002759 DoxX-like family; Region: DoxX_2; pfam13564 926562002760 Pirin; Region: Pirin; pfam02678 926562002761 Pirin-related protein [General function prediction only]; Region: COG1741 926562002762 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 926562002763 short chain dehydrogenase; Provisional; Region: PRK07478 926562002764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926562002765 NAD(P) binding site [chemical binding]; other site 926562002766 active site 926562002767 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 926562002768 Pirin; Region: Pirin; pfam02678 926562002769 Pirin-related protein [General function prediction only]; Region: COG1741 926562002770 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 926562002771 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 926562002772 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 926562002773 tetramer interface [polypeptide binding]; other site 926562002774 TPP-binding site [chemical binding]; other site 926562002775 heterodimer interface [polypeptide binding]; other site 926562002776 phosphorylation loop region [posttranslational modification] 926562002777 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 926562002778 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 926562002779 alpha subunit interface [polypeptide binding]; other site 926562002780 TPP binding site [chemical binding]; other site 926562002781 heterodimer interface [polypeptide binding]; other site 926562002782 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 926562002783 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 926562002784 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 926562002785 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 926562002786 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 926562002787 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 926562002788 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 926562002789 putative rRNA binding site [nucleotide binding]; other site 926562002790 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 926562002791 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 926562002792 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 926562002793 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 926562002794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 926562002795 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 926562002796 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 926562002797 Beta-lactamase; Region: Beta-lactamase; cl17358 926562002798 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 926562002799 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 926562002800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562002801 ATP binding site [chemical binding]; other site 926562002802 Mg2+ binding site [ion binding]; other site 926562002803 G-X-G motif; other site 926562002804 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 926562002805 ATP binding site [chemical binding]; other site 926562002806 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 926562002807 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 926562002808 Rhomboid family; Region: Rhomboid; pfam01694 926562002809 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 926562002810 putative catalytic site [active] 926562002811 putative metal binding site [ion binding]; other site 926562002812 putative phosphate binding site [ion binding]; other site 926562002813 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 926562002814 active site flap/lid [active] 926562002815 nucleophilic elbow; other site 926562002816 catalytic triad [active] 926562002817 META domain; Region: META; pfam03724 926562002818 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 926562002819 active site 926562002820 MgtC family; Region: MgtC; pfam02308 926562002821 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 926562002822 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 926562002823 dimer interface [polypeptide binding]; other site 926562002824 decamer (pentamer of dimers) interface [polypeptide binding]; other site 926562002825 catalytic triad [active] 926562002826 peroxidatic and resolving cysteines [active] 926562002827 ZIP Zinc transporter; Region: Zip; pfam02535 926562002828 Methyltransferase domain; Region: Methyltransf_23; pfam13489 926562002829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562002830 S-adenosylmethionine binding site [chemical binding]; other site 926562002831 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 926562002832 hypothetical protein; Provisional; Region: PRK10621 926562002833 SnoaL-like domain; Region: SnoaL_2; pfam12680 926562002834 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926562002835 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 926562002836 dimer interface [polypeptide binding]; other site 926562002837 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 926562002838 Na binding site [ion binding]; other site 926562002839 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 926562002840 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 926562002841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 926562002842 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 926562002843 ArsC family; Region: ArsC; pfam03960 926562002844 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926562002845 primosomal protein N' Region: priA; TIGR00595 926562002846 ATP binding site [chemical binding]; other site 926562002847 putative Mg++ binding site [ion binding]; other site 926562002848 helicase superfamily c-terminal domain; Region: HELICc; smart00490 926562002849 ATP-binding site [chemical binding]; other site 926562002850 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 926562002851 YhhN-like protein; Region: YhhN; pfam07947 926562002852 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 926562002853 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 926562002854 putative dimer interface [polypeptide binding]; other site 926562002855 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 926562002856 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 926562002857 active site 926562002858 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 926562002859 oligomerization interface [polypeptide binding]; other site 926562002860 active site 926562002861 metal binding site [ion binding]; metal-binding site 926562002862 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 926562002863 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 926562002864 nucleotide binding site [chemical binding]; other site 926562002865 NEF interaction site [polypeptide binding]; other site 926562002866 SBD interface [polypeptide binding]; other site 926562002867 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926562002868 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562002869 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926562002870 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926562002871 ligand binding site [chemical binding]; other site 926562002872 flexible hinge region; other site 926562002873 DinB superfamily; Region: DinB_2; pfam12867 926562002874 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 926562002875 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 926562002876 active site 926562002877 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 926562002878 dimer interface [polypeptide binding]; other site 926562002879 catalytic triad [active] 926562002880 peroxidatic and resolving cysteines [active] 926562002881 Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672 926562002882 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 926562002883 catalytic residues [active] 926562002884 exopolyphosphatase; Region: exo_poly_only; TIGR03706 926562002885 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 926562002886 polyphosphate kinase; Provisional; Region: PRK05443 926562002887 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 926562002888 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 926562002889 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 926562002890 domain interface [polypeptide binding]; other site 926562002891 active site 926562002892 catalytic site [active] 926562002893 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 926562002894 domain interface [polypeptide binding]; other site 926562002895 active site 926562002896 catalytic site [active] 926562002897 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 926562002898 catalytic core [active] 926562002899 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 926562002900 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 926562002901 homodimer interface [polypeptide binding]; other site 926562002902 metal binding site [ion binding]; metal-binding site 926562002903 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 926562002904 homodimer interface [polypeptide binding]; other site 926562002905 active site 926562002906 putative chemical substrate binding site [chemical binding]; other site 926562002907 metal binding site [ion binding]; metal-binding site 926562002908 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 926562002909 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 926562002910 active site 926562002911 catalytic residues [active] 926562002912 metal binding site [ion binding]; metal-binding site 926562002913 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926562002914 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926562002915 ligand binding site [chemical binding]; other site 926562002916 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 926562002917 Uncharacterized conserved protein [Function unknown]; Region: COG2353 926562002918 DoxX-like family; Region: DoxX_2; pfam13564 926562002919 short chain dehydrogenase; Provisional; Region: PRK06197 926562002920 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 926562002921 putative NAD(P) binding site [chemical binding]; other site 926562002922 active site 926562002923 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 926562002924 Helix-turn-helix domain; Region: HTH_18; pfam12833 926562002925 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926562002926 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926562002927 dimerization interface [polypeptide binding]; other site 926562002928 putative DNA binding site [nucleotide binding]; other site 926562002929 putative Zn2+ binding site [ion binding]; other site 926562002930 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 926562002931 putative NAD(P) binding site [chemical binding]; other site 926562002932 homodimer interface [polypeptide binding]; other site 926562002933 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 926562002934 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926562002935 Uncharacterized conserved protein [Function unknown]; Region: COG2128 926562002936 HeH/LEM domain; Region: HeH; pfam12949 926562002937 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 926562002938 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 926562002939 NADP binding site [chemical binding]; other site 926562002940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926562002941 AAA domain; Region: AAA_21; pfam13304 926562002942 Walker A/P-loop; other site 926562002943 ATP binding site [chemical binding]; other site 926562002944 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 926562002945 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 926562002946 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 926562002947 trimer interface [polypeptide binding]; other site 926562002948 active site 926562002949 substrate binding site [chemical binding]; other site 926562002950 CoA binding site [chemical binding]; other site 926562002951 putative hydrolase; Provisional; Region: PRK02113 926562002952 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 926562002953 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 926562002954 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 926562002955 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926562002956 catalytic residue [active] 926562002957 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 926562002958 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 926562002959 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926562002960 catalytic residue [active] 926562002961 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 926562002962 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 926562002963 active site 926562002964 substrate binding site [chemical binding]; other site 926562002965 metal binding site [ion binding]; metal-binding site 926562002966 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562002967 binding surface 926562002968 TPR motif; other site 926562002969 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562002970 TPR motif; other site 926562002971 binding surface 926562002972 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562002973 binding surface 926562002974 TPR motif; other site 926562002975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562002976 binding surface 926562002977 TPR motif; other site 926562002978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562002979 TPR motif; other site 926562002980 binding surface 926562002981 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 926562002982 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 926562002983 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 926562002984 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 926562002985 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 926562002986 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 926562002987 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 926562002988 putative acyl-acceptor binding pocket; other site 926562002989 Methyltransferase domain; Region: Methyltransf_31; pfam13847 926562002990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562002991 S-adenosylmethionine binding site [chemical binding]; other site 926562002992 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 926562002993 active sites [active] 926562002994 tetramer interface [polypeptide binding]; other site 926562002995 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 926562002996 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 926562002997 NAD(P) binding site [chemical binding]; other site 926562002998 homotetramer interface [polypeptide binding]; other site 926562002999 homodimer interface [polypeptide binding]; other site 926562003000 active site 926562003001 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 926562003002 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 926562003003 dimer interface [polypeptide binding]; other site 926562003004 active site 926562003005 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 926562003006 putative acyl-acceptor binding pocket; other site 926562003007 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 926562003008 active site 2 [active] 926562003009 dimer interface [polypeptide binding]; other site 926562003010 active site 1 [active] 926562003011 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 926562003012 active site 926562003013 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 926562003014 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 926562003015 active site 926562003016 Phosphopantetheine attachment site; Region: PP-binding; cl09936 926562003017 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 926562003018 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 926562003019 dimer interface [polypeptide binding]; other site 926562003020 active site 926562003021 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 926562003022 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 926562003023 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 926562003024 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 926562003025 NodB motif; other site 926562003026 active site 926562003027 catalytic site [active] 926562003028 metal binding site [ion binding]; metal-binding site 926562003029 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 926562003030 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 926562003031 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 926562003032 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 926562003033 Ligand binding site; other site 926562003034 Putative Catalytic site; other site 926562003035 DXD motif; other site 926562003036 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 926562003037 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 926562003038 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 926562003039 acyl-activating enzyme (AAE) consensus motif; other site 926562003040 active site 926562003041 AMP binding site [chemical binding]; other site 926562003042 CoA binding site [chemical binding]; other site 926562003043 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 926562003044 active site 926562003045 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 926562003046 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 926562003047 putative active site [active] 926562003048 Domain of unknown function (DUF368); Region: DUF368; pfam04018 926562003049 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 926562003050 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 926562003051 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 926562003052 shikimate binding site; other site 926562003053 NAD(P) binding site [chemical binding]; other site 926562003054 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 926562003055 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 926562003056 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 926562003057 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562003058 Transglutaminase/protease-like homologues; Region: TGc; smart00460 926562003059 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 926562003060 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 926562003061 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 926562003062 clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934 926562003063 NADP binding site [chemical binding]; other site 926562003064 homotetramer interface [polypeptide binding]; other site 926562003065 homodimer interface [polypeptide binding]; other site 926562003066 active site 926562003067 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 926562003068 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 926562003069 NAD(P) binding site [chemical binding]; other site 926562003070 catalytic residues [active] 926562003071 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 926562003072 Fatty acid desaturase; Region: FA_desaturase; pfam00487 926562003073 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 926562003074 putative di-iron ligands [ion binding]; other site 926562003075 excinuclease ABC subunit B; Provisional; Region: PRK05298 926562003076 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926562003077 ATP binding site [chemical binding]; other site 926562003078 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926562003079 nucleotide binding region [chemical binding]; other site 926562003080 ATP-binding site [chemical binding]; other site 926562003081 Ultra-violet resistance protein B; Region: UvrB; pfam12344 926562003082 UvrB/uvrC motif; Region: UVR; pfam02151 926562003083 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562003084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 926562003085 binding surface 926562003086 TPR motif; other site 926562003087 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562003088 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 926562003089 Histidine kinase; Region: HisKA_2; pfam07568 926562003090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562003091 ATP binding site [chemical binding]; other site 926562003092 Mg2+ binding site [ion binding]; other site 926562003093 G-X-G motif; other site 926562003094 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 926562003095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562003096 active site 926562003097 phosphorylation site [posttranslational modification] 926562003098 intermolecular recognition site; other site 926562003099 dimerization interface [polypeptide binding]; other site 926562003100 LytTr DNA-binding domain; Region: LytTR; smart00850 926562003101 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 926562003102 active site 926562003103 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 926562003104 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 926562003105 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 926562003106 active site 926562003107 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 926562003108 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 926562003109 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 926562003110 DHH family; Region: DHH; pfam01368 926562003111 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 926562003112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926562003113 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 926562003114 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 926562003115 YceI-like domain; Region: YceI; pfam04264 926562003116 Predicted dehydrogenase [General function prediction only]; Region: COG0579 926562003117 hydroxyglutarate oxidase; Provisional; Region: PRK11728 926562003118 Uncharacterized conserved protein [Function unknown]; Region: COG3379 926562003119 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 926562003120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562003121 binding surface 926562003122 TPR motif; other site 926562003123 TPR repeat; Region: TPR_11; pfam13414 926562003124 TPR repeat; Region: TPR_11; pfam13414 926562003125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 926562003126 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926562003127 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 926562003128 FtsX-like permease family; Region: FtsX; pfam02687 926562003129 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 926562003130 ribosomal protein L33; Region: rpl33; CHL00104 926562003131 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 926562003132 competence damage-inducible protein A; Provisional; Region: PRK00549 926562003133 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 926562003134 putative MPT binding site; other site 926562003135 Competence-damaged protein; Region: CinA; pfam02464 926562003136 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 926562003137 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 926562003138 Transglycosylase; Region: Transgly; pfam00912 926562003139 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 926562003140 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562003141 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926562003142 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926562003143 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926562003144 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562003145 Peptidase family M23; Region: Peptidase_M23; pfam01551 926562003146 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 926562003147 Spc7 kinetochore protein; Region: Spc7; pfam08317 926562003148 Cell division protein ZapA; Region: ZapA; pfam05164 926562003149 phosphodiesterase; Provisional; Region: PRK12704 926562003150 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 926562003151 putative transposase OrfB; Reviewed; Region: PHA02517 926562003152 Integrase core domain; Region: rve; pfam00665 926562003153 Integrase core domain; Region: rve_3; pfam13683 926562003154 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 926562003155 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 926562003156 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 926562003157 Ligand Binding Site [chemical binding]; other site 926562003158 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 926562003159 Ligand Binding Site [chemical binding]; other site 926562003160 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 926562003161 putative active site [active] 926562003162 Zn binding site [ion binding]; other site 926562003163 Protein of unknown function (DUF429); Region: DUF429; cl12046 926562003164 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926562003165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562003166 active site 926562003167 phosphorylation site [posttranslational modification] 926562003168 intermolecular recognition site; other site 926562003169 dimerization interface [polypeptide binding]; other site 926562003170 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926562003171 DNA binding site [nucleotide binding] 926562003172 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562003173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562003174 dimer interface [polypeptide binding]; other site 926562003175 phosphorylation site [posttranslational modification] 926562003176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562003177 ATP binding site [chemical binding]; other site 926562003178 Mg2+ binding site [ion binding]; other site 926562003179 G-X-G motif; other site 926562003180 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562003181 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 926562003182 Ligand binding site; other site 926562003183 Putative Catalytic site; other site 926562003184 DXD motif; other site 926562003185 Integrase core domain; Region: rve; pfam00665 926562003186 Integrase core domain; Region: rve_3; pfam13683 926562003187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 926562003188 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562003189 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926562003190 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926562003191 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 926562003192 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 926562003193 DNA polymerase III, delta subunit; Region: holA; TIGR01128 926562003194 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 926562003195 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 926562003196 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 926562003197 putative RNA binding site [nucleotide binding]; other site 926562003198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562003199 S-adenosylmethionine binding site [chemical binding]; other site 926562003200 adenylosuccinate lyase; Provisional; Region: PRK09285 926562003201 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 926562003202 tetramer interface [polypeptide binding]; other site 926562003203 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 926562003204 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 926562003205 putative active site [active] 926562003206 Zn binding site [ion binding]; other site 926562003207 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 926562003208 Aconitate hydratase 2 N-terminus; Region: Aconitase_2_N; pfam06434 926562003209 substrate binding site [chemical binding]; other site 926562003210 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 926562003211 substrate binding site [chemical binding]; other site 926562003212 ligand binding site [chemical binding]; other site 926562003213 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 926562003214 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584 926562003215 substrate binding site [chemical binding]; other site 926562003216 ligand binding site [chemical binding]; other site 926562003217 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 926562003218 substrate binding site [chemical binding]; other site 926562003219 Hemerythrin-like domain; Region: Hr-like; cd12108 926562003220 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926562003221 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 926562003222 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 926562003223 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 926562003224 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 926562003225 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 926562003226 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 926562003227 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 926562003228 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562003229 Walker A motif; other site 926562003230 ATP binding site [chemical binding]; other site 926562003231 Walker B motif; other site 926562003232 arginine finger; other site 926562003233 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 926562003234 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 926562003235 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 926562003236 Phage protein D [General function prediction only]; Region: COG3500 926562003237 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 926562003238 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 926562003239 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 926562003240 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 926562003241 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 926562003242 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 926562003243 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 926562003244 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 926562003245 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 926562003246 active site 926562003247 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 926562003248 6-phosphofructokinase; Provisional; Region: PRK03202 926562003249 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 926562003250 active site 926562003251 ADP/pyrophosphate binding site [chemical binding]; other site 926562003252 dimerization interface [polypeptide binding]; other site 926562003253 allosteric effector site; other site 926562003254 fructose-1,6-bisphosphate binding site; other site 926562003255 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 926562003256 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 926562003257 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 926562003258 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 926562003259 beta-phosphoglucomutase; Region: bPGM; TIGR01990 926562003260 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926562003261 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 926562003262 active site 926562003263 dimer interfaces [polypeptide binding]; other site 926562003264 catalytic residues [active] 926562003265 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562003266 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562003267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562003268 binding surface 926562003269 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562003270 TPR motif; other site 926562003271 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562003272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562003273 binding surface 926562003274 TPR motif; other site 926562003275 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 926562003276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562003277 active site 926562003278 phosphorylation site [posttranslational modification] 926562003279 intermolecular recognition site; other site 926562003280 dimerization interface [polypeptide binding]; other site 926562003281 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 926562003282 transketolase; Reviewed; Region: PRK05899 926562003283 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 926562003284 TPP-binding site [chemical binding]; other site 926562003285 dimer interface [polypeptide binding]; other site 926562003286 von Willebrand factor type A domain; Region: VWA_2; pfam13519 926562003287 metal ion-dependent adhesion site (MIDAS); other site 926562003288 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 926562003289 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 926562003290 PYR/PP interface [polypeptide binding]; other site 926562003291 dimer interface [polypeptide binding]; other site 926562003292 TPP binding site [chemical binding]; other site 926562003293 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 926562003294 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 926562003295 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926562003296 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926562003297 DNA binding residues [nucleotide binding] 926562003298 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 926562003299 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 926562003300 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 926562003301 Flavodoxin; Region: Flavodoxin_1; pfam00258 926562003302 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 926562003303 FAD binding pocket [chemical binding]; other site 926562003304 conserved FAD binding motif [chemical binding]; other site 926562003305 phosphate binding motif [ion binding]; other site 926562003306 beta-alpha-beta structure motif; other site 926562003307 NAD binding pocket [chemical binding]; other site 926562003308 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 926562003309 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 926562003310 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 926562003311 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 926562003312 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 926562003313 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 926562003314 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 926562003315 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 926562003316 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 926562003317 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562003318 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926562003319 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562003320 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 926562003321 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 926562003322 active site 926562003323 DNA binding site [nucleotide binding] 926562003324 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 926562003325 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562003326 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 926562003327 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 926562003328 active site 926562003329 PHP Thumb interface [polypeptide binding]; other site 926562003330 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 926562003331 PIN domain; Region: PIN_3; pfam13470 926562003332 Protein of unknown function DUF72; Region: DUF72; pfam01904 926562003333 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 926562003334 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 926562003335 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562003336 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 926562003337 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 926562003338 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926562003339 catalytic residue [active] 926562003340 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 926562003341 AAA domain; Region: AAA_26; pfam13500 926562003342 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 926562003343 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 926562003344 inhibitor-cofactor binding pocket; inhibition site 926562003345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562003346 catalytic residue [active] 926562003347 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 926562003348 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 926562003349 active site 926562003350 biotin synthase; Region: bioB; TIGR00433 926562003351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926562003352 FeS/SAM binding site; other site 926562003353 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 926562003354 short chain dehydrogenase; Provisional; Region: PRK07326 926562003355 classical (c) SDR, subgroup 4; Region: SDR_c4; cd08929 926562003356 putative NAD(P) binding site [chemical binding]; other site 926562003357 homodimer interface [polypeptide binding]; other site 926562003358 active site 926562003359 HlyD family secretion protein; Region: HlyD_2; pfam12700 926562003360 HlyD family secretion protein; Region: HlyD_3; pfam13437 926562003361 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926562003362 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 926562003363 FtsX-like permease family; Region: FtsX; pfam02687 926562003364 Outer membrane efflux protein; Region: OEP; pfam02321 926562003365 Outer membrane efflux protein; Region: OEP; pfam02321 926562003366 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 926562003367 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 926562003368 putative acyl-acceptor binding pocket; other site 926562003369 AAA domain; Region: AAA_30; pfam13604 926562003370 Family description; Region: UvrD_C_2; pfam13538 926562003371 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 926562003372 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 926562003373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562003374 S-adenosylmethionine binding site [chemical binding]; other site 926562003375 hydroperoxidase II; Provisional; Region: katE; PRK11249 926562003376 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 926562003377 tetramer interface [polypeptide binding]; other site 926562003378 heme binding pocket [chemical binding]; other site 926562003379 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 926562003380 domain interactions; other site 926562003381 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 926562003382 active site 926562003383 dimerization interface [polypeptide binding]; other site 926562003384 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 926562003385 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 926562003386 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 926562003387 dimerization interface [polypeptide binding]; other site 926562003388 active site 926562003389 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 926562003390 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 926562003391 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926562003392 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 926562003393 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926562003394 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562003395 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 926562003396 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 926562003397 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 926562003398 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926562003399 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 926562003400 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 926562003401 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 926562003402 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926562003403 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926562003404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562003405 S-adenosylmethionine binding site [chemical binding]; other site 926562003406 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 926562003407 FOG: CBS domain [General function prediction only]; Region: COG0517 926562003408 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926562003409 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 926562003410 active site 926562003411 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 926562003412 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 926562003413 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 926562003414 inhibitor-cofactor binding pocket; inhibition site 926562003415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562003416 catalytic residue [active] 926562003417 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 926562003418 extended (e) SDRs; Region: SDR_e; cd08946 926562003419 NAD(P) binding site [chemical binding]; other site 926562003420 active site 926562003421 substrate binding site [chemical binding]; other site 926562003422 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 926562003423 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 926562003424 Family description; Region: VCBS; pfam13517 926562003425 Family description; Region: VCBS; pfam13517 926562003426 Family description; Region: VCBS; pfam13517 926562003427 Family description; Region: VCBS; pfam13517 926562003428 Family description; Region: VCBS; pfam13517 926562003429 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 926562003430 FOG: PKD repeat [General function prediction only]; Region: COG3291 926562003431 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562003432 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562003433 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562003434 FOG: PKD repeat [General function prediction only]; Region: COG3291 926562003435 FOG: PKD repeat [General function prediction only]; Region: COG3291 926562003436 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562003437 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562003438 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562003439 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 926562003440 active site 926562003441 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 926562003442 homodimer interface [polypeptide binding]; other site 926562003443 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 926562003444 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 926562003445 ATP-grasp domain; Region: ATP-grasp_4; cl17255 926562003446 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 926562003447 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 926562003448 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 926562003449 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 926562003450 ATP-grasp domain; Region: ATP-grasp_4; cl17255 926562003451 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 926562003452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926562003453 short chain dehydrogenase; Provisional; Region: PRK06181 926562003454 NAD(P) binding site [chemical binding]; other site 926562003455 active site 926562003456 Oxoglutarate and iron-dependent oxygenase degradation C-term; Region: Ofd1_CTDD; pfam10637 926562003457 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 926562003458 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 926562003459 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 926562003460 NADP binding site [chemical binding]; other site 926562003461 active site 926562003462 putative substrate binding site [chemical binding]; other site 926562003463 PspC domain; Region: PspC; pfam04024 926562003464 Ion channel; Region: Ion_trans_2; pfam07885 926562003465 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 926562003466 TrkA-N domain; Region: TrkA_N; pfam02254 926562003467 TrkA-C domain; Region: TrkA_C; pfam02080 926562003468 PspC domain; Region: PspC; cl00864 926562003469 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 926562003470 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 926562003471 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 926562003472 catalytic nucleophile [active] 926562003473 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 926562003474 Mechanosensitive ion channel; Region: MS_channel; pfam00924 926562003475 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 926562003476 MarR family; Region: MarR_2; pfam12802 926562003477 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562003478 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 926562003479 active site 926562003480 dimer interface [polypeptide binding]; other site 926562003481 peptide chain release factor 1; Validated; Region: prfA; PRK00591 926562003482 This domain is found in peptide chain release factors; Region: PCRF; smart00937 926562003483 RF-1 domain; Region: RF-1; pfam00472 926562003484 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 926562003485 dimerization interface [polypeptide binding]; other site 926562003486 ATP binding site [chemical binding]; other site 926562003487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562003488 binding surface 926562003489 TPR motif; other site 926562003490 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562003491 Tetratricopeptide repeat; Region: TPR_16; pfam13432 926562003492 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 926562003493 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926562003494 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 926562003495 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926562003496 ligand binding site [chemical binding]; other site 926562003497 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 926562003498 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 926562003499 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 926562003500 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 926562003501 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 926562003502 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 926562003503 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 926562003504 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 926562003505 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 926562003506 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 926562003507 Protein export membrane protein; Region: SecD_SecF; pfam02355 926562003508 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562003509 Family description; Region: VCBS; pfam13517 926562003510 FG-GAP repeat; Region: FG-GAP; pfam01839 926562003511 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562003512 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 926562003513 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 926562003514 active site 926562003515 oxyanion hole [active] 926562003516 catalytic triad [active] 926562003517 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 926562003518 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562003519 AAA domain; Region: AAA_30; pfam13604 926562003520 PIF1-like helicase; Region: PIF1; pfam05970 926562003521 Family description; Region: UvrD_C_2; pfam13538 926562003522 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 926562003523 Ycf48-like protein; Provisional; Region: PRK13684 926562003524 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562003525 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 926562003526 Z1 domain; Region: Z1; pfam10593 926562003527 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 926562003528 ATP binding site [chemical binding]; other site 926562003529 Mg2+ binding site [ion binding]; other site 926562003530 G-X-G motif; other site 926562003531 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 926562003532 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 926562003533 cofactor binding site; other site 926562003534 DNA binding site [nucleotide binding] 926562003535 substrate interaction site [chemical binding]; other site 926562003536 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 926562003537 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926562003538 non-specific DNA binding site [nucleotide binding]; other site 926562003539 salt bridge; other site 926562003540 sequence-specific DNA binding site [nucleotide binding]; other site 926562003541 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 926562003542 additional DNA contacts [nucleotide binding]; other site 926562003543 mismatch recognition site; other site 926562003544 active site 926562003545 zinc binding site [ion binding]; other site 926562003546 DNA intercalation site [nucleotide binding]; other site 926562003547 Predicted transcriptional regulators [Transcription]; Region: COG1510 926562003548 MarR family; Region: MarR_2; pfam12802 926562003549 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 926562003550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562003551 Walker A motif; other site 926562003552 ATP binding site [chemical binding]; other site 926562003553 Walker B motif; other site 926562003554 arginine finger; other site 926562003555 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 926562003556 B12 binding site [chemical binding]; other site 926562003557 cobalt ligand [ion binding]; other site 926562003558 ArgK protein; Region: ArgK; pfam03308 926562003559 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 926562003560 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 926562003561 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 926562003562 Stage II sporulation protein; Region: SpoIID; pfam08486 926562003563 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 926562003564 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 926562003565 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 926562003566 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 926562003567 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 926562003568 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 926562003569 Penicillinase repressor; Region: Pencillinase_R; pfam03965 926562003570 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 926562003571 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 926562003572 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 926562003573 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926562003574 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 926562003575 FeS/SAM binding site; other site 926562003576 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 926562003577 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 926562003578 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 926562003579 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 926562003580 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 926562003581 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 926562003582 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 926562003583 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 926562003584 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 926562003585 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 926562003586 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 926562003587 DNA binding site [nucleotide binding] 926562003588 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 926562003589 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 926562003590 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 926562003591 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 926562003592 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 926562003593 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 926562003594 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 926562003595 RPB10 interaction site [polypeptide binding]; other site 926562003596 RPB3 interaction site [polypeptide binding]; other site 926562003597 RPB12 interaction site [polypeptide binding]; other site 926562003598 RPB1 interaction site [polypeptide binding]; other site 926562003599 RPB11 interaction site [polypeptide binding]; other site 926562003600 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 926562003601 core dimer interface [polypeptide binding]; other site 926562003602 peripheral dimer interface [polypeptide binding]; other site 926562003603 L10 interface [polypeptide binding]; other site 926562003604 L11 interface [polypeptide binding]; other site 926562003605 putative EF-Tu interaction site [polypeptide binding]; other site 926562003606 putative EF-G interaction site [polypeptide binding]; other site 926562003607 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 926562003608 23S rRNA interface [nucleotide binding]; other site 926562003609 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 926562003610 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 926562003611 mRNA/rRNA interface [nucleotide binding]; other site 926562003612 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 926562003613 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 926562003614 23S rRNA interface [nucleotide binding]; other site 926562003615 L7/L12 interface [polypeptide binding]; other site 926562003616 putative thiostrepton binding site; other site 926562003617 L25 interface [polypeptide binding]; other site 926562003618 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 926562003619 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 926562003620 putative homodimer interface [polypeptide binding]; other site 926562003621 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 926562003622 heterodimer interface [polypeptide binding]; other site 926562003623 homodimer interface [polypeptide binding]; other site 926562003624 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 926562003625 elongation factor Tu; Reviewed; Region: PRK12735 926562003626 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 926562003627 G1 box; other site 926562003628 GEF interaction site [polypeptide binding]; other site 926562003629 GTP/Mg2+ binding site [chemical binding]; other site 926562003630 Switch I region; other site 926562003631 G2 box; other site 926562003632 G3 box; other site 926562003633 Switch II region; other site 926562003634 G4 box; other site 926562003635 G5 box; other site 926562003636 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 926562003637 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 926562003638 Antibiotic Binding Site [chemical binding]; other site 926562003639 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 926562003640 30S subunit binding site; other site 926562003641 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926562003642 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 926562003643 active site 926562003644 DNA binding site [nucleotide binding] 926562003645 Int/Topo IB signature motif; other site 926562003646 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 926562003647 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 926562003648 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 926562003649 active site 926562003650 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 926562003651 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 926562003652 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 926562003653 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 926562003654 Aquifex aeolicus LeuT and related proteins; solute binding domain; Region: LeuT-like_sbd; cd10333 926562003655 Na2 binding site [ion binding]; other site 926562003656 substrate binding site 1 [chemical binding]; other site 926562003657 Na binding site 1 [ion binding]; other site 926562003658 substrate binding site 2 [chemical binding]; other site 926562003659 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 926562003660 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 926562003661 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 926562003662 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926562003663 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 926562003664 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 926562003665 Walker A/P-loop; other site 926562003666 ATP binding site [chemical binding]; other site 926562003667 Q-loop/lid; other site 926562003668 ABC transporter signature motif; other site 926562003669 Walker B; other site 926562003670 D-loop; other site 926562003671 H-loop/switch region; other site 926562003672 Septum formation initiator; Region: DivIC; pfam04977 926562003673 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 926562003674 heterodimer interface [polypeptide binding]; other site 926562003675 substrate interaction site [chemical binding]; other site 926562003676 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 926562003677 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 926562003678 active site 926562003679 substrate binding site [chemical binding]; other site 926562003680 coenzyme B12 binding site [chemical binding]; other site 926562003681 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 926562003682 B12 binding site [chemical binding]; other site 926562003683 cobalt ligand [ion binding]; other site 926562003684 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 926562003685 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 926562003686 membrane ATPase/protein kinase; Provisional; Region: PRK09435 926562003687 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 926562003688 Walker A; other site 926562003689 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562003690 aspartate aminotransferase; Provisional; Region: PRK05764 926562003691 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 926562003692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562003693 homodimer interface [polypeptide binding]; other site 926562003694 catalytic residue [active] 926562003695 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 926562003696 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 926562003697 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 926562003698 putative active site [active] 926562003699 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 926562003700 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 926562003701 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 926562003702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562003703 S-adenosylmethionine binding site [chemical binding]; other site 926562003704 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926562003705 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 926562003706 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 926562003707 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 926562003708 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 926562003709 oligomer interface [polypeptide binding]; other site 926562003710 metal binding site [ion binding]; metal-binding site 926562003711 metal binding site [ion binding]; metal-binding site 926562003712 Cl binding site [ion binding]; other site 926562003713 aspartate ring; other site 926562003714 basic sphincter; other site 926562003715 putative hydrophobic gate; other site 926562003716 periplasmic entrance; other site 926562003717 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 926562003718 EamA-like transporter family; Region: EamA; pfam00892 926562003719 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 926562003720 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 926562003721 Surface antigen; Region: Bac_surface_Ag; pfam01103 926562003722 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 926562003723 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 926562003724 putative active site; other site 926562003725 catalytic residue [active] 926562003726 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 926562003727 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 926562003728 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 926562003729 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 926562003730 16S/18S rRNA binding site [nucleotide binding]; other site 926562003731 S13e-L30e interaction site [polypeptide binding]; other site 926562003732 25S rRNA binding site [nucleotide binding]; other site 926562003733 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 926562003734 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 926562003735 RNase E interface [polypeptide binding]; other site 926562003736 trimer interface [polypeptide binding]; other site 926562003737 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 926562003738 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 926562003739 RNase E interface [polypeptide binding]; other site 926562003740 trimer interface [polypeptide binding]; other site 926562003741 active site 926562003742 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 926562003743 putative nucleic acid binding region [nucleotide binding]; other site 926562003744 G-X-X-G motif; other site 926562003745 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 926562003746 RNA binding site [nucleotide binding]; other site 926562003747 domain interface; other site 926562003748 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 926562003749 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 926562003750 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926562003751 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 926562003752 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926562003753 DNA binding residues [nucleotide binding] 926562003754 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 926562003755 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 926562003756 substrate binding site [chemical binding]; other site 926562003757 hexamer interface [polypeptide binding]; other site 926562003758 metal binding site [ion binding]; metal-binding site 926562003759 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 926562003760 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 926562003761 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 926562003762 putative acyl-acceptor binding pocket; other site 926562003763 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 926562003764 Saccharopine Dehydrogenase like proteins; Region: SDH_like; cd05199 926562003765 active site 926562003766 ligand binding site [chemical binding]; other site 926562003767 NAD(P) binding site [chemical binding]; other site 926562003768 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562003769 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562003770 OmpW family; Region: OmpW; cl17427 926562003771 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926562003772 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926562003773 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926562003774 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926562003775 DNA binding residues [nucleotide binding] 926562003776 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562003777 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562003778 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562003779 FOG: PKD repeat [General function prediction only]; Region: COG3291 926562003780 PKD domain; Region: PKD; pfam00801 926562003781 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562003782 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562003783 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 926562003784 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 926562003785 G1 box; other site 926562003786 putative GEF interaction site [polypeptide binding]; other site 926562003787 GTP/Mg2+ binding site [chemical binding]; other site 926562003788 Switch I region; other site 926562003789 G2 box; other site 926562003790 G3 box; other site 926562003791 Switch II region; other site 926562003792 G4 box; other site 926562003793 G5 box; other site 926562003794 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 926562003795 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 926562003796 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562003797 ferrochelatase; Reviewed; Region: hemH; PRK00035 926562003798 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 926562003799 C-terminal domain interface [polypeptide binding]; other site 926562003800 active site 926562003801 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 926562003802 active site 926562003803 N-terminal domain interface [polypeptide binding]; other site 926562003804 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 926562003805 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926562003806 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 926562003807 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 926562003808 tRNA; other site 926562003809 putative tRNA binding site [nucleotide binding]; other site 926562003810 putative NADP binding site [chemical binding]; other site 926562003811 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 926562003812 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 926562003813 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 926562003814 domain interfaces; other site 926562003815 active site 926562003816 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 926562003817 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 926562003818 active site 926562003819 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 926562003820 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 926562003821 substrate binding site [chemical binding]; other site 926562003822 active site 926562003823 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 926562003824 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 926562003825 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 926562003826 dimer interface [polypeptide binding]; other site 926562003827 allosteric magnesium binding site [ion binding]; other site 926562003828 active site 926562003829 aspartate-rich active site metal binding site; other site 926562003830 Schiff base residues; other site 926562003831 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 926562003832 four helix bundle protein; Region: TIGR02436 926562003833 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 926562003834 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 926562003835 inhibitor-cofactor binding pocket; inhibition site 926562003836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562003837 catalytic residue [active] 926562003838 Imelysin; Region: Peptidase_M75; pfam09375 926562003839 Imelysin; Region: Peptidase_M75; cl09159 926562003840 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 926562003841 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 926562003842 Imelysin; Region: Peptidase_M75; pfam09375 926562003843 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 926562003844 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562003845 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 926562003846 N-terminal plug; other site 926562003847 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 926562003848 ligand-binding site [chemical binding]; other site 926562003849 Uncharacterized conserved protein [Function unknown]; Region: COG3391 926562003850 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562003851 Uncharacterized conserved protein [Function unknown]; Region: COG3391 926562003852 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562003853 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 926562003854 ligand binding site [chemical binding]; other site 926562003855 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562003856 Predicted transcriptional regulator [Transcription]; Region: COG1959 926562003857 Transcriptional regulator; Region: Rrf2; pfam02082 926562003858 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 926562003859 active site 926562003860 DNA polymerase IV; Validated; Region: PRK02406 926562003861 DNA binding site [nucleotide binding] 926562003862 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 926562003863 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 926562003864 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 926562003865 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 926562003866 ATP-grasp domain; Region: ATP-grasp_4; cl17255 926562003867 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 926562003868 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 926562003869 active site 926562003870 (T/H)XGH motif; other site 926562003871 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 926562003872 active site 926562003873 Ap6A binding site [chemical binding]; other site 926562003874 nudix motif; other site 926562003875 metal binding site [ion binding]; metal-binding site 926562003876 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926562003877 active site 926562003878 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 926562003879 hydrophobic ligand binding site; other site 926562003880 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 926562003881 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 926562003882 Oligomerisation domain; Region: Oligomerisation; pfam02410 926562003883 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 926562003884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562003885 Walker A motif; other site 926562003886 ATP binding site [chemical binding]; other site 926562003887 Walker B motif; other site 926562003888 arginine finger; other site 926562003889 Peptidase family M41; Region: Peptidase_M41; pfam01434 926562003890 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 926562003891 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 926562003892 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 926562003893 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 926562003894 Acyl CoA binding protein; Region: ACBP; pfam00887 926562003895 acyl-CoA binding pocket [chemical binding]; other site 926562003896 CoA binding site [chemical binding]; other site 926562003897 cytidylate kinase; Provisional; Region: cmk; PRK00023 926562003898 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 926562003899 CMP-binding site; other site 926562003900 The sites determining sugar specificity; other site 926562003901 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 926562003902 Found in ATP-dependent protease La (LON); Region: LON; smart00464 926562003903 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562003904 Walker A motif; other site 926562003905 ATP binding site [chemical binding]; other site 926562003906 Walker B motif; other site 926562003907 arginine finger; other site 926562003908 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 926562003909 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 926562003910 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 926562003911 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 926562003912 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 926562003913 hypothetical protein; Validated; Region: PRK02101 926562003914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 926562003915 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 926562003916 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 926562003917 Glutamate binding site [chemical binding]; other site 926562003918 NAD binding site [chemical binding]; other site 926562003919 catalytic residues [active] 926562003920 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 926562003921 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 926562003922 active site 926562003923 metal binding site [ion binding]; metal-binding site 926562003924 DNA polymerase III subunit beta; Validated; Region: PRK05643 926562003925 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 926562003926 putative DNA binding surface [nucleotide binding]; other site 926562003927 dimer interface [polypeptide binding]; other site 926562003928 beta-clamp/clamp loader binding surface; other site 926562003929 beta-clamp/translesion DNA polymerase binding surface; other site 926562003930 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 926562003931 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 926562003932 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 926562003933 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 926562003934 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 926562003935 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 926562003936 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 926562003937 PhoH-like protein; Region: PhoH; pfam02562 926562003938 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 926562003939 ATP binding site [chemical binding]; other site 926562003940 active site 926562003941 substrate binding site [chemical binding]; other site 926562003942 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 926562003943 active site 926562003944 catalytic site [active] 926562003945 substrate binding site [chemical binding]; other site 926562003946 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 926562003947 GIY-YIG motif/motif A; other site 926562003948 active site 926562003949 catalytic site [active] 926562003950 metal binding site [ion binding]; metal-binding site 926562003951 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562003952 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 926562003953 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 926562003954 catalytic residue [active] 926562003955 Uncharacterized conserved protein [Function unknown]; Region: COG4198 926562003956 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 926562003957 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 926562003958 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 926562003959 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 926562003960 Response regulator receiver domain; Region: Response_reg; pfam00072 926562003961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562003962 active site 926562003963 phosphorylation site [posttranslational modification] 926562003964 intermolecular recognition site; other site 926562003965 dimerization interface [polypeptide binding]; other site 926562003966 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926562003967 PAS fold; Region: PAS_3; pfam08447 926562003968 putative active site [active] 926562003969 heme pocket [chemical binding]; other site 926562003970 PAS domain S-box; Region: sensory_box; TIGR00229 926562003971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926562003972 putative active site [active] 926562003973 heme pocket [chemical binding]; other site 926562003974 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562003975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562003976 ATP binding site [chemical binding]; other site 926562003977 Mg2+ binding site [ion binding]; other site 926562003978 G-X-G motif; other site 926562003979 Haem-binding domain; Region: Haem_bd; pfam14376 926562003980 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 926562003981 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 926562003982 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 926562003983 Active site serine [active] 926562003984 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 926562003985 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 926562003986 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 926562003987 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926562003988 acetyl-CoA synthetase; Provisional; Region: PRK00174 926562003989 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 926562003990 active site 926562003991 CoA binding site [chemical binding]; other site 926562003992 acyl-activating enzyme (AAE) consensus motif; other site 926562003993 AMP binding site [chemical binding]; other site 926562003994 acetate binding site [chemical binding]; other site 926562003995 Protein of unknown function (DUF779); Region: DUF779; pfam05610 926562003996 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 926562003997 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 926562003998 NAD(P) binding site [chemical binding]; other site 926562003999 catalytic residues [active] 926562004000 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926562004001 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 926562004002 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926562004003 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 926562004004 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 926562004005 active site 926562004006 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 926562004007 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926562004008 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926562004009 DNA binding residues [nucleotide binding] 926562004010 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926562004011 FOG: PKD repeat [General function prediction only]; Region: COG3291 926562004012 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562004013 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562004014 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 926562004015 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 926562004016 dimer interface [polypeptide binding]; other site 926562004017 active site 926562004018 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 926562004019 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 926562004020 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 926562004021 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 926562004022 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 926562004023 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 926562004024 substrate binding site [chemical binding]; other site 926562004025 oxyanion hole (OAH) forming residues; other site 926562004026 trimer interface [polypeptide binding]; other site 926562004027 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 926562004028 MarR family; Region: MarR_2; pfam12802 926562004029 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 926562004030 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 926562004031 active site 926562004032 fumarate hydratase; Reviewed; Region: fumC; PRK00485 926562004033 Class II fumarases; Region: Fumarase_classII; cd01362 926562004034 active site 926562004035 tetramer interface [polypeptide binding]; other site 926562004036 SdpI/YhfL protein family; Region: SdpI; pfam13630 926562004037 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 926562004038 Peptidase family M23; Region: Peptidase_M23; pfam01551 926562004039 Bacterial SH3 domain homologues; Region: SH3b; smart00287 926562004040 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 926562004041 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926562004042 Coenzyme A binding pocket [chemical binding]; other site 926562004043 Predicted amidohydrolase [General function prediction only]; Region: COG0388 926562004044 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 926562004045 putative active site [active] 926562004046 catalytic triad [active] 926562004047 putative dimer interface [polypeptide binding]; other site 926562004048 Protein of unknown function, DUF479; Region: DUF479; cl01203 926562004049 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 926562004050 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 926562004051 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 926562004052 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 926562004053 putative active site [active] 926562004054 catalytic triad [active] 926562004055 putative dimer interface [polypeptide binding]; other site 926562004056 putative transposase OrfB; Reviewed; Region: PHA02517 926562004057 Integrase core domain; Region: rve; pfam00665 926562004058 Integrase core domain; Region: rve_3; pfam13683 926562004059 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 926562004060 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562004061 Fibronectin type 3 domain; Region: FN3; smart00060 926562004062 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562004063 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562004064 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 926562004065 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 926562004066 tetramer interface [polypeptide binding]; other site 926562004067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562004068 catalytic residue [active] 926562004069 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 926562004070 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562004071 RecX family; Region: RecX; pfam02631 926562004072 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 926562004073 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 926562004074 seryl-tRNA synthetase; Provisional; Region: PRK05431 926562004075 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 926562004076 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 926562004077 motif 1; other site 926562004078 dimer interface [polypeptide binding]; other site 926562004079 active site 926562004080 motif 2; other site 926562004081 motif 3; other site 926562004082 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 926562004083 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 926562004084 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 926562004085 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 926562004086 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 926562004087 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 926562004088 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 926562004089 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 926562004090 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 926562004091 EamA-like transporter family; Region: EamA; pfam00892 926562004092 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 926562004093 EamA-like transporter family; Region: EamA; pfam00892 926562004094 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 926562004095 putative acyl-acceptor binding pocket; other site 926562004096 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 926562004097 Pyrococcus aspartate kinase subunit, putative; Region: AspKin_pair; TIGR02078 926562004098 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 926562004099 nucleotide binding site [chemical binding]; other site 926562004100 substrate binding site [chemical binding]; other site 926562004101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926562004102 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 926562004103 putative active site [active] 926562004104 heme pocket [chemical binding]; other site 926562004105 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926562004106 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 926562004107 putative active site [active] 926562004108 heme pocket [chemical binding]; other site 926562004109 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926562004110 putative active site [active] 926562004111 heme pocket [chemical binding]; other site 926562004112 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 926562004113 GAF domain; Region: GAF; pfam01590 926562004114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926562004115 putative active site [active] 926562004116 PAS fold; Region: PAS_3; pfam08447 926562004117 heme pocket [chemical binding]; other site 926562004118 Response regulator receiver domain; Region: Response_reg; pfam00072 926562004119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562004120 active site 926562004121 phosphorylation site [posttranslational modification] 926562004122 intermolecular recognition site; other site 926562004123 dimerization interface [polypeptide binding]; other site 926562004124 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 926562004125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926562004126 Coenzyme A binding pocket [chemical binding]; other site 926562004127 diaminopimelate decarboxylase; Region: lysA; TIGR01048 926562004128 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 926562004129 active site 926562004130 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 926562004131 substrate binding site [chemical binding]; other site 926562004132 catalytic residues [active] 926562004133 dimer interface [polypeptide binding]; other site 926562004134 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 926562004135 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 926562004136 NAD binding site [chemical binding]; other site 926562004137 substrate binding site [chemical binding]; other site 926562004138 homodimer interface [polypeptide binding]; other site 926562004139 active site 926562004140 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 926562004141 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 926562004142 NAD binding site [chemical binding]; other site 926562004143 homodimer interface [polypeptide binding]; other site 926562004144 active site 926562004145 substrate binding site [chemical binding]; other site 926562004146 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 926562004147 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 926562004148 NAD binding site [chemical binding]; other site 926562004149 putative substrate binding site 2 [chemical binding]; other site 926562004150 putative substrate binding site 1 [chemical binding]; other site 926562004151 active site 926562004152 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 926562004153 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 926562004154 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 926562004155 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 926562004156 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 926562004157 inhibitor-cofactor binding pocket; inhibition site 926562004158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562004159 catalytic residue [active] 926562004160 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 926562004161 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 926562004162 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 926562004163 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926562004164 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 926562004165 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926562004166 Sulfatase; Region: Sulfatase; pfam00884 926562004167 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926562004168 tellurium resistance terB-like protein; Region: terB_like; cl11965 926562004169 metal binding site [ion binding]; metal-binding site 926562004170 Ecdysteroid kinase; Region: EcKinase; cl17738 926562004171 Phosphotransferase enzyme family; Region: APH; pfam01636 926562004172 YHYH protein; Region: YHYH; pfam14240 926562004173 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 926562004174 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 926562004175 dimer interface [polypeptide binding]; other site 926562004176 active site 926562004177 heme binding site [chemical binding]; other site 926562004178 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 926562004179 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 926562004180 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 926562004181 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 926562004182 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 926562004183 putative hydrophobic ligand binding site [chemical binding]; other site 926562004184 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 926562004185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562004186 S-adenosylmethionine binding site [chemical binding]; other site 926562004187 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 926562004188 AMP binding site [chemical binding]; other site 926562004189 metal binding site [ion binding]; metal-binding site 926562004190 active site 926562004191 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926562004192 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562004193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926562004194 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 926562004195 NAD(P) binding site [chemical binding]; other site 926562004196 active site 926562004197 CARDB; Region: CARDB; pfam07705 926562004198 CARDB; Region: CARDB; pfam07705 926562004199 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 926562004200 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 926562004201 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 926562004202 nucleotide binding site [chemical binding]; other site 926562004203 homotetrameric interface [polypeptide binding]; other site 926562004204 putative phosphate binding site [ion binding]; other site 926562004205 putative allosteric binding site; other site 926562004206 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 926562004207 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 926562004208 putative catalytic cysteine [active] 926562004209 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562004210 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 926562004211 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 926562004212 N-terminal plug; other site 926562004213 ligand-binding site [chemical binding]; other site 926562004214 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 926562004215 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 926562004216 intersubunit interface [polypeptide binding]; other site 926562004217 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 926562004218 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 926562004219 ABC-ATPase subunit interface; other site 926562004220 dimer interface [polypeptide binding]; other site 926562004221 putative PBP binding regions; other site 926562004222 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 926562004223 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 926562004224 Walker A/P-loop; other site 926562004225 ATP binding site [chemical binding]; other site 926562004226 Q-loop/lid; other site 926562004227 ABC transporter signature motif; other site 926562004228 Walker B; other site 926562004229 D-loop; other site 926562004230 H-loop/switch region; other site 926562004231 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 926562004232 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562004233 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 926562004234 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 926562004235 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926562004236 ATP binding site [chemical binding]; other site 926562004237 putative Mg++ binding site [ion binding]; other site 926562004238 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926562004239 nucleotide binding region [chemical binding]; other site 926562004240 ATP-binding site [chemical binding]; other site 926562004241 TRCF domain; Region: TRCF; pfam03461 926562004242 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 926562004243 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 926562004244 RES domain; Region: RES; pfam08808 926562004245 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 926562004246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562004247 active site 926562004248 phosphorylation site [posttranslational modification] 926562004249 intermolecular recognition site; other site 926562004250 dimerization interface [polypeptide binding]; other site 926562004251 LytTr DNA-binding domain; Region: LytTR; smart00850 926562004252 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 926562004253 Histidine kinase; Region: His_kinase; pfam06580 926562004254 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562004255 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926562004256 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562004257 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926562004258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562004259 active site 926562004260 phosphorylation site [posttranslational modification] 926562004261 intermolecular recognition site; other site 926562004262 dimerization interface [polypeptide binding]; other site 926562004263 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926562004264 DNA binding site [nucleotide binding] 926562004265 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 926562004266 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 926562004267 dimerization interface [polypeptide binding]; other site 926562004268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562004269 dimer interface [polypeptide binding]; other site 926562004270 phosphorylation site [posttranslational modification] 926562004271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562004272 ATP binding site [chemical binding]; other site 926562004273 Mg2+ binding site [ion binding]; other site 926562004274 G-X-G motif; other site 926562004275 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926562004276 catalytic residues [active] 926562004277 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 926562004278 Fasciclin domain; Region: Fasciclin; pfam02469 926562004279 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 926562004280 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 926562004281 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 926562004282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562004283 active site 926562004284 phosphorylation site [posttranslational modification] 926562004285 intermolecular recognition site; other site 926562004286 dimerization interface [polypeptide binding]; other site 926562004287 LytTr DNA-binding domain; Region: LytTR; smart00850 926562004288 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 926562004289 Histidine kinase; Region: His_kinase; pfam06580 926562004290 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 926562004291 Methyltransferase domain; Region: Methyltransf_31; pfam13847 926562004292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562004293 S-adenosylmethionine binding site [chemical binding]; other site 926562004294 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 926562004295 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 926562004296 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 926562004297 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926562004298 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 926562004299 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 926562004300 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 926562004301 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 926562004302 Walker A/P-loop; other site 926562004303 ATP binding site [chemical binding]; other site 926562004304 Q-loop/lid; other site 926562004305 ABC transporter signature motif; other site 926562004306 Walker B; other site 926562004307 D-loop; other site 926562004308 H-loop/switch region; other site 926562004309 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 926562004310 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 926562004311 O-Antigen ligase; Region: Wzy_C; pfam04932 926562004312 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926562004313 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 926562004314 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 926562004315 putative ADP-binding pocket [chemical binding]; other site 926562004316 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926562004317 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 926562004318 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 926562004319 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 926562004320 putative ligand binding site [chemical binding]; other site 926562004321 NAD binding site [chemical binding]; other site 926562004322 dimerization interface [polypeptide binding]; other site 926562004323 catalytic site [active] 926562004324 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 926562004325 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926562004326 catalytic residue [active] 926562004327 4Fe-4S binding domain; Region: Fer4; cl02805 926562004328 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 926562004329 NAD(P) binding site [chemical binding]; other site 926562004330 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 926562004331 PASTA domain; Region: PASTA; pfam03793 926562004332 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562004333 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 926562004334 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 926562004335 RNA binding surface [nucleotide binding]; other site 926562004336 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 926562004337 active site 926562004338 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 926562004339 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 926562004340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562004341 S-adenosylmethionine binding site [chemical binding]; other site 926562004342 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926562004343 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926562004344 active site 926562004345 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 926562004346 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 926562004347 Predicted permeases [General function prediction only]; Region: COG0795 926562004348 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 926562004349 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 926562004350 EamA-like transporter family; Region: EamA; pfam00892 926562004351 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 926562004352 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 926562004353 replicative DNA helicase; Region: DnaB; TIGR00665 926562004354 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 926562004355 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 926562004356 Walker A motif; other site 926562004357 ATP binding site [chemical binding]; other site 926562004358 Walker B motif; other site 926562004359 DNA binding loops [nucleotide binding] 926562004360 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 926562004361 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 926562004362 classical (c) SDRs; Region: SDR_c; cd05233 926562004363 NAD(P) binding site [chemical binding]; other site 926562004364 active site 926562004365 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 926562004366 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 926562004367 E3 interaction surface; other site 926562004368 lipoyl attachment site [posttranslational modification]; other site 926562004369 e3 binding domain; Region: E3_binding; pfam02817 926562004370 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 926562004371 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 926562004372 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 926562004373 tetramer interface [polypeptide binding]; other site 926562004374 TPP-binding site [chemical binding]; other site 926562004375 heterodimer interface [polypeptide binding]; other site 926562004376 phosphorylation loop region [posttranslational modification] 926562004377 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 926562004378 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 926562004379 active site 926562004380 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 926562004381 Bacteroidetes-specific putative membrane protein; Region: Bac_Flav_fam_1; TIGR03519 926562004382 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 926562004383 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 926562004384 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 926562004385 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 926562004386 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 926562004387 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 926562004388 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 926562004389 FAD binding site [chemical binding]; other site 926562004390 homotetramer interface [polypeptide binding]; other site 926562004391 substrate binding pocket [chemical binding]; other site 926562004392 catalytic base [active] 926562004393 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 926562004394 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 926562004395 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 926562004396 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 926562004397 NAD(P) binding pocket [chemical binding]; other site 926562004398 NHAD transporter family protein; Provisional; Region: PLN00137 926562004399 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 926562004400 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 926562004401 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 926562004402 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 926562004403 Gram-negative bacterial tonB protein; Region: TonB; cl10048 926562004404 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 926562004405 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 926562004406 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562004407 O-methyltransferase; Region: Methyltransf_2; pfam00891 926562004408 Protein of unknown function, DUF481; Region: DUF481; cl01213 926562004409 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 926562004410 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 926562004411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562004412 Walker A motif; other site 926562004413 ATP binding site [chemical binding]; other site 926562004414 Walker B motif; other site 926562004415 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 926562004416 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 926562004417 recombinase A; Provisional; Region: recA; PRK09354 926562004418 hexamer interface [polypeptide binding]; other site 926562004419 Walker A motif; other site 926562004420 ATP binding site [chemical binding]; other site 926562004421 Walker B motif; other site 926562004422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562004423 TPR motif; other site 926562004424 binding surface 926562004425 TPR repeat; Region: TPR_11; pfam13414 926562004426 TPR repeat; Region: TPR_11; pfam13414 926562004427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562004428 TPR motif; other site 926562004429 binding surface 926562004430 TPR repeat; Region: TPR_11; pfam13414 926562004431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562004432 binding surface 926562004433 TPR motif; other site 926562004434 TPR repeat; Region: TPR_11; pfam13414 926562004435 Protein of unknown function (DUF1039); Region: DUF1039; cl05668 926562004436 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 926562004437 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 926562004438 active site 926562004439 catalytic site [active] 926562004440 short chain dehydrogenase; Provisional; Region: PRK07677 926562004441 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 926562004442 NAD(P) binding site [chemical binding]; other site 926562004443 substrate binding site [chemical binding]; other site 926562004444 homotetramer interface [polypeptide binding]; other site 926562004445 active site 926562004446 homodimer interface [polypeptide binding]; other site 926562004447 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 926562004448 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 926562004449 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 926562004450 ArsC family; Region: ArsC; pfam03960 926562004451 catalytic residues [active] 926562004452 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562004453 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 926562004454 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562004455 peptide chain release factor 2; Validated; Region: prfB; PRK00578 926562004456 This domain is found in peptide chain release factors; Region: PCRF; smart00937 926562004457 RF-1 domain; Region: RF-1; pfam00472 926562004458 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 926562004459 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 926562004460 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926562004461 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 926562004462 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 926562004463 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926562004464 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 926562004465 putative active site [active] 926562004466 heme pocket [chemical binding]; other site 926562004467 GAF domain; Region: GAF; pfam01590 926562004468 GAF domain; Region: GAF_2; pfam13185 926562004469 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562004470 dimer interface [polypeptide binding]; other site 926562004471 phosphorylation site [posttranslational modification] 926562004472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562004473 ATP binding site [chemical binding]; other site 926562004474 Mg2+ binding site [ion binding]; other site 926562004475 G-X-G motif; other site 926562004476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562004477 active site 926562004478 phosphorylation site [posttranslational modification] 926562004479 intermolecular recognition site; other site 926562004480 dimerization interface [polypeptide binding]; other site 926562004481 Response regulator receiver domain; Region: Response_reg; pfam00072 926562004482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562004483 active site 926562004484 phosphorylation site [posttranslational modification] 926562004485 intermolecular recognition site; other site 926562004486 dimerization interface [polypeptide binding]; other site 926562004487 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 926562004488 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 926562004489 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 926562004490 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 926562004491 Ligand Binding Site [chemical binding]; other site 926562004492 TilS substrate C-terminal domain; Region: TilS_C; smart00977 926562004493 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 926562004494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926562004495 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 926562004496 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562004497 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562004498 Fibronectin type 3 domain; Region: FN3; smart00060 926562004499 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562004500 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562004501 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 926562004502 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 926562004503 catalytic triad [active] 926562004504 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 926562004505 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 926562004506 minor groove reading motif; other site 926562004507 helix-hairpin-helix signature motif; other site 926562004508 substrate binding pocket [chemical binding]; other site 926562004509 active site 926562004510 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 926562004511 Surface antigen; Region: Bac_surface_Ag; pfam01103 926562004512 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 926562004513 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 926562004514 kynureninase; Region: kynureninase; TIGR01814 926562004515 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 926562004516 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926562004517 catalytic residue [active] 926562004518 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 926562004519 glycine dehydrogenase; Provisional; Region: PRK05367 926562004520 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 926562004521 tetramer interface [polypeptide binding]; other site 926562004522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562004523 catalytic residue [active] 926562004524 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 926562004525 tetramer interface [polypeptide binding]; other site 926562004526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562004527 catalytic residue [active] 926562004528 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562004529 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 926562004530 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 926562004531 Walker A/P-loop; other site 926562004532 ATP binding site [chemical binding]; other site 926562004533 Q-loop/lid; other site 926562004534 ABC transporter signature motif; other site 926562004535 Walker B; other site 926562004536 D-loop; other site 926562004537 H-loop/switch region; other site 926562004538 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 926562004539 Permease; Region: Permease; pfam02405 926562004540 SprT homologues; Region: SprT; cl01182 926562004541 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 926562004542 ATP-grasp domain; Region: ATP-grasp; pfam02222 926562004543 AIR carboxylase; Region: AIRC; pfam00731 926562004544 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 926562004545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562004546 active site 926562004547 phosphorylation site [posttranslational modification] 926562004548 intermolecular recognition site; other site 926562004549 dimerization interface [polypeptide binding]; other site 926562004550 LytTr DNA-binding domain; Region: LytTR; smart00850 926562004551 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 926562004552 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 926562004553 Histidine kinase; Region: His_kinase; pfam06580 926562004554 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 926562004555 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 926562004556 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 926562004557 TPR repeat; Region: TPR_11; pfam13414 926562004558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562004559 binding surface 926562004560 TPR motif; other site 926562004561 TPR repeat; Region: TPR_11; pfam13414 926562004562 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 926562004563 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 926562004564 hinge; other site 926562004565 active site 926562004566 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 926562004567 active site 926562004568 dimer interface [polypeptide binding]; other site 926562004569 metal binding site [ion binding]; metal-binding site 926562004570 Proline dehydrogenase; Region: Pro_dh; cl03282 926562004571 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562004572 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 926562004573 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926562004574 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926562004575 DNA binding residues [nucleotide binding] 926562004576 Spindle and kinetochore-associated protein 3, N-terminal domain; Region: SKA3_N; cd12957 926562004577 SKA1 interface [polypeptide binding]; other site 926562004578 SKA2 interface [polypeptide binding]; other site 926562004579 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 926562004580 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 926562004581 hexamer interface [polypeptide binding]; other site 926562004582 ligand binding site [chemical binding]; other site 926562004583 putative active site [active] 926562004584 NAD(P) binding site [chemical binding]; other site 926562004585 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 926562004586 Response regulator receiver domain; Region: Response_reg; pfam00072 926562004587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562004588 active site 926562004589 phosphorylation site [posttranslational modification] 926562004590 intermolecular recognition site; other site 926562004591 dimerization interface [polypeptide binding]; other site 926562004592 PglZ domain; Region: PglZ; pfam08665 926562004593 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 926562004594 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926562004595 Zn2+ binding site [ion binding]; other site 926562004596 Mg2+ binding site [ion binding]; other site 926562004597 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 926562004598 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 926562004599 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 926562004600 trimer interface [polypeptide binding]; other site 926562004601 active site 926562004602 UDP-GlcNAc binding site [chemical binding]; other site 926562004603 lipid binding site [chemical binding]; lipid-binding site 926562004604 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 926562004605 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 926562004606 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 926562004607 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 926562004608 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 926562004609 active site 926562004610 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 926562004611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926562004612 Walker A/P-loop; other site 926562004613 ATP binding site [chemical binding]; other site 926562004614 Q-loop/lid; other site 926562004615 ABC transporter signature motif; other site 926562004616 Walker B; other site 926562004617 D-loop; other site 926562004618 elongation factor P; Validated; Region: PRK00529 926562004619 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 926562004620 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 926562004621 RNA binding site [nucleotide binding]; other site 926562004622 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 926562004623 RNA binding site [nucleotide binding]; other site 926562004624 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 926562004625 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 926562004626 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 926562004627 trimer interface [polypeptide binding]; other site 926562004628 active site 926562004629 UDP-GlcNAc binding site [chemical binding]; other site 926562004630 lipid binding site [chemical binding]; lipid-binding site 926562004631 Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741 926562004632 starch binding outer membrane protein SusD; Region: SusD; cl17845 926562004633 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926562004634 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562004635 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926562004636 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562004637 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 926562004638 O-Antigen ligase; Region: Wzy_C; pfam04932 926562004639 Chain length determinant protein; Region: Wzz; cl15801 926562004640 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 926562004641 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 926562004642 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926562004643 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 926562004644 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 926562004645 RNA/DNA hybrid binding site [nucleotide binding]; other site 926562004646 active site 926562004647 putative pectinesterase; Region: PLN02432; cl01911 926562004648 Right handed beta helix region; Region: Beta_helix; pfam13229 926562004649 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 926562004650 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562004651 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 926562004652 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926562004653 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926562004654 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 926562004655 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 926562004656 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926562004657 catalytic residue [active] 926562004658 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 926562004659 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 926562004660 catalytic residues [active] 926562004661 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 926562004662 active site 926562004663 zinc binding site [ion binding]; other site 926562004664 Phosphate transporter family; Region: PHO4; pfam01384 926562004665 hypothetical protein; Provisional; Region: PRK08201 926562004666 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 926562004667 metal binding site [ion binding]; metal-binding site 926562004668 putative dimer interface [polypeptide binding]; other site 926562004669 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 926562004670 nudix motif; other site 926562004671 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562004672 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 926562004673 UbiA prenyltransferase family; Region: UbiA; pfam01040 926562004674 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 926562004675 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 926562004676 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 926562004677 diphosphomevalonate decarboxylase; Region: PLN02407 926562004678 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 926562004679 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 926562004680 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 926562004681 four helix bundle protein; Region: TIGR02436 926562004682 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 926562004683 active site 926562004684 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 926562004685 Repair protein; Region: Repair_PSII; pfam04536 926562004686 Repair protein; Region: Repair_PSII; pfam04536 926562004687 LemA family; Region: LemA; pfam04011 926562004688 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 926562004689 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 926562004690 DNA binding residues [nucleotide binding] 926562004691 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 926562004692 Peptidase family M23; Region: Peptidase_M23; pfam01551 926562004693 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 926562004694 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 926562004695 motif 1; other site 926562004696 active site 926562004697 motif 2; other site 926562004698 motif 3; other site 926562004699 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 926562004700 DHHA1 domain; Region: DHHA1; pfam02272 926562004701 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 926562004702 Divergent AAA domain; Region: AAA_4; pfam04326 926562004703 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 926562004704 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 926562004705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926562004706 putative substrate translocation pore; other site 926562004707 POT family; Region: PTR2; cl17359 926562004708 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 926562004709 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 926562004710 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 926562004711 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 926562004712 cyclohexanol reductases, including levodione reductase, classical (c) SDRs; Region: cyclohexanol_reductase_SDR_c; cd05330 926562004713 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 926562004714 NAD binding site [chemical binding]; other site 926562004715 homotetramer interface [polypeptide binding]; other site 926562004716 homodimer interface [polypeptide binding]; other site 926562004717 active site 926562004718 substrate binding site [chemical binding]; other site 926562004719 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 926562004720 Cytochrome P450; Region: p450; pfam00067 926562004721 urocanate hydratase; Provisional; Region: PRK05414 926562004722 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 926562004723 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 926562004724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926562004725 short chain dehydrogenase; Provisional; Region: PRK06181 926562004726 NAD(P) binding site [chemical binding]; other site 926562004727 active site 926562004728 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 926562004729 active site 926562004730 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926562004731 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 926562004732 active site 926562004733 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 926562004734 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 926562004735 active site 926562004736 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926562004737 CHASE domain; Region: CHASE; pfam03924 926562004738 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562004739 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562004740 dimer interface [polypeptide binding]; other site 926562004741 phosphorylation site [posttranslational modification] 926562004742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562004743 ATP binding site [chemical binding]; other site 926562004744 Mg2+ binding site [ion binding]; other site 926562004745 G-X-G motif; other site 926562004746 Response regulator receiver domain; Region: Response_reg; pfam00072 926562004747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562004748 active site 926562004749 phosphorylation site [posttranslational modification] 926562004750 intermolecular recognition site; other site 926562004751 dimerization interface [polypeptide binding]; other site 926562004752 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 926562004753 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 926562004754 Glycoprotease family; Region: Peptidase_M22; pfam00814 926562004755 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926562004756 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 926562004757 HlyD family secretion protein; Region: HlyD_3; pfam13437 926562004758 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 926562004759 Protein of unknown function (DUF420); Region: DUF420; pfam04238 926562004760 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 926562004761 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 926562004762 Cu(I) binding site [ion binding]; other site 926562004763 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 926562004764 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 926562004765 Subunit I/III interface [polypeptide binding]; other site 926562004766 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 926562004767 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 926562004768 Subunit I/III interface [polypeptide binding]; other site 926562004769 protoheme IX farnesyltransferase; Region: cyoE_ctaB; TIGR01473 926562004770 UbiA prenyltransferase family; Region: UbiA; pfam01040 926562004771 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 926562004772 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 926562004773 active site 926562004774 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 926562004775 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 926562004776 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 926562004777 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 926562004778 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 926562004779 lipoyl attachment site [posttranslational modification]; other site 926562004780 cell surface protein SprA; Region: surface_SprA; TIGR04189 926562004781 Motility related/secretion protein; Region: SprA_N; pfam14349 926562004782 Motility related/secretion protein; Region: SprA_N; pfam14349 926562004783 Motility related/secretion protein; Region: SprA_N; pfam14349 926562004784 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 926562004785 RuvA N terminal domain; Region: RuvA_N; pfam01330 926562004786 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 926562004787 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562004788 Outer membrane protein Omp28; Region: Omp28; pfam11551 926562004789 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562004790 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926562004791 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926562004792 catalytic residues [active] 926562004793 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 926562004794 Outer membrane protein Omp28; Region: Omp28; pfam11551 926562004795 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926562004796 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 926562004797 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 926562004798 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 926562004799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562004800 Walker A motif; other site 926562004801 ATP binding site [chemical binding]; other site 926562004802 Walker B motif; other site 926562004803 arginine finger; other site 926562004804 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 926562004805 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 926562004806 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 926562004807 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 926562004808 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 926562004809 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 926562004810 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 926562004811 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 926562004812 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 926562004813 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 926562004814 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 926562004815 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 926562004816 molybdopterin cofactor binding site; other site 926562004817 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 926562004818 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 926562004819 4Fe-4S binding domain; Region: Fer4; cl02805 926562004820 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 926562004821 Cytochrome c; Region: Cytochrom_C; pfam00034 926562004822 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 926562004823 heme-binding residues [chemical binding]; other site 926562004824 Sporulation related domain; Region: SPOR; cl10051 926562004825 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 926562004826 Integrase core domain; Region: rve; pfam00665 926562004827 Integrase core domain; Region: rve_3; pfam13683 926562004828 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 926562004829 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562004830 translation initiation factor IF-2; Region: IF-2; TIGR00487 926562004831 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 926562004832 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 926562004833 G1 box; other site 926562004834 putative GEF interaction site [polypeptide binding]; other site 926562004835 GTP/Mg2+ binding site [chemical binding]; other site 926562004836 Switch I region; other site 926562004837 G2 box; other site 926562004838 G3 box; other site 926562004839 Switch II region; other site 926562004840 G4 box; other site 926562004841 G5 box; other site 926562004842 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 926562004843 Translation-initiation factor 2; Region: IF-2; pfam11987 926562004844 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 926562004845 transcription termination factor NusA; Region: NusA; TIGR01953 926562004846 NusA N-terminal domain; Region: NusA_N; pfam08529 926562004847 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 926562004848 RNA binding site [nucleotide binding]; other site 926562004849 homodimer interface [polypeptide binding]; other site 926562004850 NusA-like KH domain; Region: KH_5; pfam13184 926562004851 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 926562004852 G-X-X-G motif; other site 926562004853 Sm and related proteins; Region: Sm_like; cl00259 926562004854 Sm1 motif; other site 926562004855 hexamer interface [polypeptide binding]; other site 926562004856 RNA binding site [nucleotide binding]; other site 926562004857 NAD-dependent deacetylase; Provisional; Region: PRK00481 926562004858 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 926562004859 NAD+ binding site [chemical binding]; other site 926562004860 substrate binding site [chemical binding]; other site 926562004861 Zn binding site [ion binding]; other site 926562004862 Response regulator receiver domain; Region: Response_reg; pfam00072 926562004863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562004864 active site 926562004865 phosphorylation site [posttranslational modification] 926562004866 intermolecular recognition site; other site 926562004867 dimerization interface [polypeptide binding]; other site 926562004868 Sporulation related domain; Region: SPOR; pfam05036 926562004869 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 926562004870 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 926562004871 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 926562004872 Bacitracin resistance protein BacA; Region: BacA; pfam02673 926562004873 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 926562004874 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 926562004875 RNA binding site [nucleotide binding]; other site 926562004876 active site 926562004877 Protein of unknown function (DUF419); Region: DUF419; pfam04237 926562004878 Protein of unknown function (DUF502); Region: DUF502; cl01107 926562004879 Membrane protein of unknown function; Region: DUF360; pfam04020 926562004880 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 926562004881 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 926562004882 active site 926562004883 Zn binding site [ion binding]; other site 926562004884 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 926562004885 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 926562004886 Methyltransferase domain; Region: Methyltransf_18; pfam12847 926562004887 S-adenosylmethionine binding site [chemical binding]; other site 926562004888 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 926562004889 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 926562004890 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 926562004891 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 926562004892 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 926562004893 active site 926562004894 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 926562004895 dimer interface [polypeptide binding]; other site 926562004896 substrate binding site [chemical binding]; other site 926562004897 catalytic residues [active] 926562004898 thymidine kinase; Provisional; Region: PRK04296 926562004899 antiporter inner membrane protein; Provisional; Region: PRK11670 926562004900 Domain of unknown function DUF59; Region: DUF59; pfam01883 926562004901 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 926562004902 NifU-like domain; Region: NifU; cl00484 926562004903 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 926562004904 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 926562004905 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 926562004906 dimer interface [polypeptide binding]; other site 926562004907 PYR/PP interface [polypeptide binding]; other site 926562004908 TPP binding site [chemical binding]; other site 926562004909 substrate binding site [chemical binding]; other site 926562004910 Transposase IS200 like; Region: Y1_Tnp; cl00848 926562004911 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 926562004912 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 926562004913 TPP-binding site [chemical binding]; other site 926562004914 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 926562004915 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 926562004916 Putative cyclase; Region: Cyclase; pfam04199 926562004917 coproporphyrinogen III oxidase; Provisional; Region: PRK08446 926562004918 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926562004919 FeS/SAM binding site; other site 926562004920 HemN C-terminal domain; Region: HemN_C; pfam06969 926562004921 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562004922 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562004923 phosphorylation site [posttranslational modification] 926562004924 dimer interface [polypeptide binding]; other site 926562004925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562004926 ATP binding site [chemical binding]; other site 926562004927 Mg2+ binding site [ion binding]; other site 926562004928 G-X-G motif; other site 926562004929 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 926562004930 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 926562004931 Ligand binding site; other site 926562004932 Putative Catalytic site; other site 926562004933 DXD motif; other site 926562004934 dihydroorotase; Reviewed; Region: PRK09236 926562004935 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926562004936 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 926562004937 active site 926562004938 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 926562004939 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 926562004940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926562004941 NAD(P) binding site [chemical binding]; other site 926562004942 active site 926562004943 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 926562004944 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 926562004945 active site 926562004946 HIGH motif; other site 926562004947 dimer interface [polypeptide binding]; other site 926562004948 KMSKS motif; other site 926562004949 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 926562004950 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926562004951 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926562004952 DNA binding residues [nucleotide binding] 926562004953 Anti-sigma-K factor rskA; Region: RskA; pfam10099 926562004954 PQQ-like domain; Region: PQQ_2; pfam13360 926562004955 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 926562004956 active site 926562004957 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562004958 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926562004959 non-specific DNA binding site [nucleotide binding]; other site 926562004960 salt bridge; other site 926562004961 sequence-specific DNA binding site [nucleotide binding]; other site 926562004962 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 926562004963 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 926562004964 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 926562004965 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 926562004966 PhoU domain; Region: PhoU; pfam01895 926562004967 PhoU domain; Region: PhoU; pfam01895 926562004968 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 926562004969 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562004970 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926562004971 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562004972 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926562004973 elongation factor Ts; Provisional; Region: tsf; PRK09377 926562004974 UBA/TS-N domain; Region: UBA; pfam00627 926562004975 Elongation factor TS; Region: EF_TS; pfam00889 926562004976 Elongation factor TS; Region: EF_TS; pfam00889 926562004977 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 926562004978 rRNA interaction site [nucleotide binding]; other site 926562004979 S8 interaction site; other site 926562004980 putative laminin-1 binding site; other site 926562004981 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 926562004982 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 926562004983 23S rRNA interface [nucleotide binding]; other site 926562004984 L3 interface [polypeptide binding]; other site 926562004985 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 926562004986 active site 926562004987 PKD domain; Region: PKD; pfam00801 926562004988 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562004989 DNA polymerase I; Provisional; Region: PRK05755 926562004990 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 926562004991 active site 926562004992 metal binding site 1 [ion binding]; metal-binding site 926562004993 putative 5' ssDNA interaction site; other site 926562004994 metal binding site 3; metal-binding site 926562004995 metal binding site 2 [ion binding]; metal-binding site 926562004996 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 926562004997 putative DNA binding site [nucleotide binding]; other site 926562004998 putative metal binding site [ion binding]; other site 926562004999 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 926562005000 active site 926562005001 catalytic site [active] 926562005002 substrate binding site [chemical binding]; other site 926562005003 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 926562005004 active site 926562005005 DNA binding site [nucleotide binding] 926562005006 catalytic site [active] 926562005007 phosphodiesterase YaeI; Provisional; Region: PRK11340 926562005008 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 926562005009 putative active site [active] 926562005010 putative metal binding site [ion binding]; other site 926562005011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 926562005012 Integrase core domain; Region: rve; pfam00665 926562005013 Integrase core domain; Region: rve_3; pfam13683 926562005014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926562005015 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 926562005016 NAD(P) binding site [chemical binding]; other site 926562005017 active site 926562005018 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 926562005019 C1q domain; Region: C1q; cl17543 926562005020 C1q domain; Region: C1q; cl17543 926562005021 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005022 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 926562005023 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 926562005024 active site residue [active] 926562005025 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005026 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 926562005027 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 926562005028 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 926562005029 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926562005030 catalytic residue [active] 926562005031 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 926562005032 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 926562005033 dimer interface [polypeptide binding]; other site 926562005034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562005035 catalytic residue [active] 926562005036 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005037 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 926562005038 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 926562005039 dimer interface [polypeptide binding]; other site 926562005040 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 926562005041 active site 926562005042 Fe binding site [ion binding]; other site 926562005043 Uncharacterized conserved protein [Function unknown]; Region: COG0398 926562005044 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 926562005045 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562005046 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 926562005047 Protein export membrane protein; Region: SecD_SecF; cl14618 926562005048 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 926562005049 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 926562005050 substrate binding site; other site 926562005051 tetramer interface; other site 926562005052 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 926562005053 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 926562005054 substrate binding pocket [chemical binding]; other site 926562005055 chain length determination region; other site 926562005056 substrate-Mg2+ binding site; other site 926562005057 catalytic residues [active] 926562005058 aspartate-rich region 1; other site 926562005059 active site lid residues [active] 926562005060 aspartate-rich region 2; other site 926562005061 Mechanosensitive ion channel; Region: MS_channel; pfam00924 926562005062 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 926562005063 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 926562005064 TPP-binding site [chemical binding]; other site 926562005065 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 926562005066 PYR/PP interface [polypeptide binding]; other site 926562005067 dimer interface [polypeptide binding]; other site 926562005068 TPP binding site [chemical binding]; other site 926562005069 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 926562005070 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 926562005071 E3 interaction surface; other site 926562005072 lipoyl attachment site [posttranslational modification]; other site 926562005073 e3 binding domain; Region: E3_binding; pfam02817 926562005074 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 926562005075 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 926562005076 active site 926562005077 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 926562005078 active site 926562005079 homodimer interface [polypeptide binding]; other site 926562005080 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 926562005081 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 926562005082 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562005083 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562005084 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926562005085 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562005086 rhamnose-proton symporter; Provisional; Region: PRK13499 926562005087 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 926562005088 DNA-binding site [nucleotide binding]; DNA binding site 926562005089 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 926562005090 putative dimerization interface [polypeptide binding]; other site 926562005091 putative ligand binding site [chemical binding]; other site 926562005092 Transcriptional regulators [Transcription]; Region: PurR; COG1609 926562005093 short chain dehydrogenase; Validated; Region: PRK08324 926562005094 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 926562005095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926562005096 NAD(P) binding site [chemical binding]; other site 926562005097 active site 926562005098 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 926562005099 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 926562005100 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 926562005101 nucleotide binding site [chemical binding]; other site 926562005102 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 926562005103 Cysteine-rich domain; Region: CCG; pfam02754 926562005104 Cysteine-rich domain; Region: CCG; pfam02754 926562005105 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 926562005106 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 926562005107 4Fe-4S binding domain; Region: Fer4; cl02805 926562005108 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 926562005109 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 926562005110 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 926562005111 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 926562005112 Integrase core domain; Region: rve; pfam00665 926562005113 Integrase core domain; Region: rve_3; pfam13683 926562005114 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 926562005115 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005116 CAAX protease self-immunity; Region: Abi; pfam02517 926562005117 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 926562005118 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 926562005119 FMN binding site [chemical binding]; other site 926562005120 active site 926562005121 catalytic residues [active] 926562005122 substrate binding site [chemical binding]; other site 926562005123 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 926562005124 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926562005125 FtsX-like permease family; Region: FtsX; pfam02687 926562005126 Ribosome-binding factor A; Region: RBFA; pfam02033 926562005127 Acylphosphatase; Region: Acylphosphatase; pfam00708 926562005128 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 926562005129 YtxH-like protein; Region: YtxH; pfam12732 926562005130 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 926562005131 Mechanosensitive ion channel; Region: MS_channel; pfam00924 926562005132 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 926562005133 mercuric reductase; Validated; Region: PRK06370 926562005134 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926562005135 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 926562005136 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 926562005137 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 926562005138 NAD(P) binding site [chemical binding]; other site 926562005139 catalytic residues [active] 926562005140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 926562005141 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926562005142 PGAP1-like protein; Region: PGAP1; pfam07819 926562005143 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 926562005144 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 926562005145 TraB family; Region: TraB; pfam01963 926562005146 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 926562005147 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 926562005148 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 926562005149 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 926562005150 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926562005151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562005152 active site 926562005153 phosphorylation site [posttranslational modification] 926562005154 intermolecular recognition site; other site 926562005155 dimerization interface [polypeptide binding]; other site 926562005156 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926562005157 DNA binding site [nucleotide binding] 926562005158 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 926562005159 dimerization interface [polypeptide binding]; other site 926562005160 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562005161 dimer interface [polypeptide binding]; other site 926562005162 phosphorylation site [posttranslational modification] 926562005163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562005164 ATP binding site [chemical binding]; other site 926562005165 Mg2+ binding site [ion binding]; other site 926562005166 G-X-G motif; other site 926562005167 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 926562005168 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 926562005169 Integrase core domain; Region: rve; pfam00665 926562005170 Integrase core domain; Region: rve_3; pfam13683 926562005171 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 926562005172 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 926562005173 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926562005174 ligand binding site [chemical binding]; other site 926562005175 HYR domain; Region: HYR; pfam02494 926562005176 HYR domain; Region: HYR; pfam02494 926562005177 HYR domain; Region: HYR; pfam02494 926562005178 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005179 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 926562005180 ABC1 family; Region: ABC1; cl17513 926562005181 Uncharacterized conserved protein [Function unknown]; Region: COG3937 926562005182 HlyD family secretion protein; Region: HlyD_2; pfam12700 926562005183 HlyD family secretion protein; Region: HlyD_3; pfam13437 926562005184 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 926562005185 Outer membrane efflux protein; Region: OEP; pfam02321 926562005186 Outer membrane efflux protein; Region: OEP; pfam02321 926562005187 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926562005188 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926562005189 ligand binding site [chemical binding]; other site 926562005190 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926562005191 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926562005192 ligand binding site [chemical binding]; other site 926562005193 flexible hinge region; other site 926562005194 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 926562005195 putative switch regulator; other site 926562005196 non-specific DNA interactions [nucleotide binding]; other site 926562005197 DNA binding site [nucleotide binding] 926562005198 sequence specific DNA binding site [nucleotide binding]; other site 926562005199 putative cAMP binding site [chemical binding]; other site 926562005200 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 926562005201 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 926562005202 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 926562005203 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 926562005204 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 926562005205 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 926562005206 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 926562005207 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 926562005208 RHS Repeat; Region: RHS_repeat; pfam05593 926562005209 RHS Repeat; Region: RHS_repeat; pfam05593 926562005210 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 926562005211 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005212 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 926562005213 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 926562005214 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 926562005215 Low-spin heme binding site [chemical binding]; other site 926562005216 Putative water exit pathway; other site 926562005217 Binuclear center (active site) [active] 926562005218 Putative proton exit pathway; other site 926562005219 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 926562005220 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 926562005221 Cytochrome c; Region: Cytochrom_C; pfam00034 926562005222 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 926562005223 4Fe-4S binding domain; Region: Fer4_5; pfam12801 926562005224 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 926562005225 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 926562005226 FixH; Region: FixH; pfam05751 926562005227 Family description; Region: DsbD_2; pfam13386 926562005228 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 926562005229 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926562005230 FeS/SAM binding site; other site 926562005231 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562005232 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562005233 Interdomain contacts; other site 926562005234 Cytokine receptor motif; other site 926562005235 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562005236 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562005237 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005238 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 926562005239 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926562005240 motif II; other site 926562005241 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926562005242 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 926562005243 dimer interface [polypeptide binding]; other site 926562005244 substrate binding site [chemical binding]; other site 926562005245 metal binding site [ion binding]; metal-binding site 926562005246 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 926562005247 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926562005248 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 926562005249 Walker A/P-loop; other site 926562005250 ATP binding site [chemical binding]; other site 926562005251 Q-loop/lid; other site 926562005252 ABC transporter signature motif; other site 926562005253 Walker B; other site 926562005254 D-loop; other site 926562005255 H-loop/switch region; other site 926562005256 Paraquat-inducible protein A; Region: PqiA; pfam04403 926562005257 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 926562005258 Family of unknown function (DUF490); Region: DUF490; pfam04357 926562005259 Surface antigen; Region: Bac_surface_Ag; pfam01103 926562005260 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 926562005261 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 926562005262 nucleoside/Zn binding site; other site 926562005263 dimer interface [polypeptide binding]; other site 926562005264 catalytic motif [active] 926562005265 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 926562005266 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 926562005267 dimer interface [polypeptide binding]; other site 926562005268 anticodon binding site; other site 926562005269 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 926562005270 homodimer interface [polypeptide binding]; other site 926562005271 motif 1; other site 926562005272 active site 926562005273 motif 2; other site 926562005274 GAD domain; Region: GAD; pfam02938 926562005275 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 926562005276 motif 3; other site 926562005277 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 926562005278 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 926562005279 Cl- selectivity filter; other site 926562005280 Cl- binding residues [ion binding]; other site 926562005281 pore gating glutamate residue; other site 926562005282 dimer interface [polypeptide binding]; other site 926562005283 FOG: CBS domain [General function prediction only]; Region: COG0517 926562005284 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 926562005285 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 926562005286 Asp-box motif; other site 926562005287 catalytic site [active] 926562005288 FOG: PKD repeat [General function prediction only]; Region: COG3291 926562005289 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562005290 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005291 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 926562005292 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005293 FOG: PKD repeat [General function prediction only]; Region: COG3291 926562005294 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562005295 FOG: PKD repeat [General function prediction only]; Region: COG3291 926562005296 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 926562005297 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005298 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562005299 serine racemase; Region: PLN02970 926562005300 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 926562005301 tetramer interface [polypeptide binding]; other site 926562005302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562005303 catalytic residue [active] 926562005304 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926562005305 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 926562005306 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 926562005307 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 926562005308 substrate binding site [chemical binding]; other site 926562005309 oxyanion hole (OAH) forming residues; other site 926562005310 trimer interface [polypeptide binding]; other site 926562005311 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 926562005312 active site 926562005313 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 926562005314 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562005315 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005316 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005317 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 926562005318 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926562005319 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005320 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 926562005321 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562005322 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005323 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 926562005324 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 926562005325 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 926562005326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562005327 S-adenosylmethionine binding site [chemical binding]; other site 926562005328 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 926562005329 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 926562005330 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926562005331 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 926562005332 HlyD family secretion protein; Region: HlyD_3; pfam13437 926562005333 short chain dehydrogenase; Provisional; Region: PRK06924 926562005334 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926562005335 NAD(P) binding site [chemical binding]; other site 926562005336 active site 926562005337 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 926562005338 TrkA-N domain; Region: TrkA_N; pfam02254 926562005339 TrkA-C domain; Region: TrkA_C; pfam02080 926562005340 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 926562005341 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 926562005342 homodimer interface [polypeptide binding]; other site 926562005343 substrate-cofactor binding pocket; other site 926562005344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562005345 catalytic residue [active] 926562005346 EamA-like transporter family; Region: EamA; pfam00892 926562005347 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 926562005348 EamA-like transporter family; Region: EamA; pfam00892 926562005349 hypothetical protein; Provisional; Region: PRK11820 926562005350 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 926562005351 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 926562005352 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 926562005353 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 926562005354 catalytic site [active] 926562005355 G-X2-G-X-G-K; other site 926562005356 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 926562005357 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 926562005358 active site 926562005359 (T/H)XGH motif; other site 926562005360 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 926562005361 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 926562005362 putative catalytic residues [active] 926562005363 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 926562005364 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926562005365 putative catalytic residue [active] 926562005366 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926562005367 GLPGLI family protein; Region: GLPGLI; TIGR01200 926562005368 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 926562005369 purine nucleoside phosphorylase; Provisional; Region: PRK08202 926562005370 Response regulator receiver domain; Region: Response_reg; pfam00072 926562005371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562005372 active site 926562005373 phosphorylation site [posttranslational modification] 926562005374 intermolecular recognition site; other site 926562005375 dimerization interface [polypeptide binding]; other site 926562005376 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 926562005377 DNA protecting protein DprA; Region: dprA; TIGR00732 926562005378 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 926562005379 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005380 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926562005381 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926562005382 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926562005383 DNA binding residues [nucleotide binding] 926562005384 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926562005385 Sporulation related domain; Region: SPOR; pfam05036 926562005386 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 926562005387 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 926562005388 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 926562005389 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 926562005390 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 926562005391 glutamate dehydrogenase; Provisional; Region: PRK09414 926562005392 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 926562005393 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 926562005394 NAD(P) binding site [chemical binding]; other site 926562005395 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005396 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562005397 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562005398 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562005399 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926562005400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562005401 active site 926562005402 phosphorylation site [posttranslational modification] 926562005403 intermolecular recognition site; other site 926562005404 dimerization interface [polypeptide binding]; other site 926562005405 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926562005406 DNA binding site [nucleotide binding] 926562005407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562005408 dimer interface [polypeptide binding]; other site 926562005409 phosphorylation site [posttranslational modification] 926562005410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562005411 ATP binding site [chemical binding]; other site 926562005412 Mg2+ binding site [ion binding]; other site 926562005413 G-X-G motif; other site 926562005414 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 926562005415 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 926562005416 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 926562005417 Peptidase family M48; Region: Peptidase_M48; cl12018 926562005418 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 926562005419 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926562005420 Methyltransferase domain; Region: Methyltransf_31; pfam13847 926562005421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562005422 S-adenosylmethionine binding site [chemical binding]; other site 926562005423 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 926562005424 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 926562005425 DNA binding site [nucleotide binding] 926562005426 active site 926562005427 Predicted methyltransferases [General function prediction only]; Region: COG0313 926562005428 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 926562005429 putative SAM binding site [chemical binding]; other site 926562005430 putative homodimer interface [polypeptide binding]; other site 926562005431 ribosome recycling factor; Reviewed; Region: frr; PRK00083 926562005432 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 926562005433 hinge region; other site 926562005434 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 926562005435 putative nucleotide binding site [chemical binding]; other site 926562005436 uridine monophosphate binding site [chemical binding]; other site 926562005437 homohexameric interface [polypeptide binding]; other site 926562005438 CotH protein; Region: CotH; pfam08757 926562005439 Targeting protein for Xklp2 (TPX2); Region: TPX2; pfam06886 926562005440 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 926562005441 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 926562005442 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 926562005443 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 926562005444 putative acyl-acceptor binding pocket; other site 926562005445 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 926562005446 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 926562005447 active site 926562005448 HIGH motif; other site 926562005449 dimer interface [polypeptide binding]; other site 926562005450 KMSKS motif; other site 926562005451 GTP-binding protein LepA; Provisional; Region: PRK05433 926562005452 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 926562005453 G1 box; other site 926562005454 putative GEF interaction site [polypeptide binding]; other site 926562005455 GTP/Mg2+ binding site [chemical binding]; other site 926562005456 Switch I region; other site 926562005457 G2 box; other site 926562005458 G3 box; other site 926562005459 Switch II region; other site 926562005460 G4 box; other site 926562005461 G5 box; other site 926562005462 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 926562005463 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 926562005464 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 926562005465 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562005466 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562005467 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 926562005468 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 926562005469 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 926562005470 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 926562005471 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 926562005472 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 926562005473 carboxyltransferase (CT) interaction site; other site 926562005474 biotinylation site [posttranslational modification]; other site 926562005475 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 926562005476 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 926562005477 dimer interface [polypeptide binding]; other site 926562005478 active site 926562005479 CoA binding pocket [chemical binding]; other site 926562005480 putative phosphate acyltransferase; Provisional; Region: PRK05331 926562005481 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 926562005482 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 926562005483 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 926562005484 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 926562005485 multifunctional aminopeptidase A; Provisional; Region: PRK00913 926562005486 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 926562005487 interface (dimer of trimers) [polypeptide binding]; other site 926562005488 Substrate-binding/catalytic site; other site 926562005489 Zn-binding sites [ion binding]; other site 926562005490 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562005491 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 926562005492 Lumazine binding domain; Region: Lum_binding; pfam00677 926562005493 Lumazine binding domain; Region: Lum_binding; pfam00677 926562005494 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 926562005495 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 926562005496 TPP-binding site; other site 926562005497 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 926562005498 PYR/PP interface [polypeptide binding]; other site 926562005499 dimer interface [polypeptide binding]; other site 926562005500 TPP binding site [chemical binding]; other site 926562005501 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 926562005502 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 926562005503 Protein export membrane protein; Region: SecD_SecF; cl14618 926562005504 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926562005505 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 926562005506 HlyD family secretion protein; Region: HlyD_3; pfam13437 926562005507 Outer membrane efflux protein; Region: OEP; pfam02321 926562005508 Outer membrane efflux protein; Region: OEP; pfam02321 926562005509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926562005510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 926562005511 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 926562005512 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 926562005513 putative dimer interface [polypeptide binding]; other site 926562005514 putative anticodon binding site; other site 926562005515 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 926562005516 homodimer interface [polypeptide binding]; other site 926562005517 motif 1; other site 926562005518 motif 2; other site 926562005519 active site 926562005520 motif 3; other site 926562005521 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 926562005522 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 926562005523 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 926562005524 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 926562005525 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 926562005526 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 926562005527 DNA-binding site [nucleotide binding]; DNA binding site 926562005528 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 926562005529 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926562005530 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562005531 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926562005532 Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322 926562005533 starch binding outer membrane protein SusD; Region: SusD; cd08977 926562005534 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 926562005535 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 926562005536 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 926562005537 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 926562005538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926562005539 D-galactonate transporter; Region: 2A0114; TIGR00893 926562005540 putative substrate translocation pore; other site 926562005541 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 926562005542 classical (c) SDRs; Region: SDR_c; cd05233 926562005543 NAD(P) binding site [chemical binding]; other site 926562005544 active site 926562005545 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 926562005546 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 926562005547 substrate binding site [chemical binding]; other site 926562005548 ATP binding site [chemical binding]; other site 926562005549 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 926562005550 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 926562005551 active site 926562005552 intersubunit interface [polypeptide binding]; other site 926562005553 catalytic residue [active] 926562005554 CcmE; Region: CcmE; cl00994 926562005555 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 926562005556 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 926562005557 dimer interface [polypeptide binding]; other site 926562005558 putative anticodon binding site; other site 926562005559 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 926562005560 motif 1; other site 926562005561 active site 926562005562 motif 2; other site 926562005563 motif 3; other site 926562005564 MutS domain III; Region: MutS_III; pfam05192 926562005565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926562005566 Walker A/P-loop; other site 926562005567 ATP binding site [chemical binding]; other site 926562005568 Q-loop/lid; other site 926562005569 ABC transporter signature motif; other site 926562005570 Walker B; other site 926562005571 D-loop; other site 926562005572 H-loop/switch region; other site 926562005573 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 926562005574 Protein of unknown function (DUF819); Region: DUF819; cl02317 926562005575 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005576 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 926562005577 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 926562005578 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 926562005579 PA/protease or protease-like domain interface [polypeptide binding]; other site 926562005580 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 926562005581 metal binding site [ion binding]; metal-binding site 926562005582 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 926562005583 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 926562005584 tetramer interface [polypeptide binding]; other site 926562005585 TPP-binding site [chemical binding]; other site 926562005586 heterodimer interface [polypeptide binding]; other site 926562005587 phosphorylation loop region [posttranslational modification] 926562005588 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 926562005589 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 926562005590 alpha subunit interface [polypeptide binding]; other site 926562005591 TPP binding site [chemical binding]; other site 926562005592 heterodimer interface [polypeptide binding]; other site 926562005593 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 926562005594 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 926562005595 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562005596 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 926562005597 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 926562005598 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 926562005599 substrate binding site [chemical binding]; other site 926562005600 oxyanion hole (OAH) forming residues; other site 926562005601 trimer interface [polypeptide binding]; other site 926562005602 Domain of unknown function DUF21; Region: DUF21; pfam01595 926562005603 FOG: CBS domain [General function prediction only]; Region: COG0517 926562005604 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 926562005605 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 926562005606 GxxExxY protein; Region: GxxExxY; TIGR04256 926562005607 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 926562005608 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 926562005609 substrate binding site [chemical binding]; other site 926562005610 dimer interface [polypeptide binding]; other site 926562005611 NADP binding site [chemical binding]; other site 926562005612 catalytic residues [active] 926562005613 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 926562005614 active site 2 [active] 926562005615 active site 1 [active] 926562005616 Fic family protein [Function unknown]; Region: COG3177 926562005617 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 926562005618 Fic/DOC family; Region: Fic; pfam02661 926562005619 YCII-related domain; Region: YCII; cl00999 926562005620 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 926562005621 Ferritin-like domain; Region: Ferritin; pfam00210 926562005622 ferroxidase diiron center [ion binding]; other site 926562005623 acyl-coenzyme A oxidase; Region: PLN02526 926562005624 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 926562005625 active site 926562005626 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 926562005627 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 926562005628 Fibronectin type 3 domain; Region: FN3; smart00060 926562005629 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562005630 Interdomain contacts; other site 926562005631 Cytokine receptor motif; other site 926562005632 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562005633 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562005634 Interdomain contacts; other site 926562005635 Cytokine receptor motif; other site 926562005636 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005637 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 926562005638 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 926562005639 putative trimer interface [polypeptide binding]; other site 926562005640 putative metal binding site [ion binding]; other site 926562005641 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 926562005642 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 926562005643 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 926562005644 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 926562005645 dimer interface [polypeptide binding]; other site 926562005646 active site 926562005647 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 926562005648 CoenzymeA binding site [chemical binding]; other site 926562005649 subunit interaction site [polypeptide binding]; other site 926562005650 PHB binding site; other site 926562005651 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926562005652 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005653 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 926562005654 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 926562005655 Walker A/P-loop; other site 926562005656 ATP binding site [chemical binding]; other site 926562005657 Q-loop/lid; other site 926562005658 ABC transporter signature motif; other site 926562005659 Walker B; other site 926562005660 D-loop; other site 926562005661 H-loop/switch region; other site 926562005662 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926562005663 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005664 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 926562005665 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 926562005666 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 926562005667 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 926562005668 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 926562005669 four helix bundle protein; Region: TIGR02436 926562005670 enoyl-CoA hydratase; Provisional; Region: PRK08140 926562005671 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 926562005672 substrate binding site [chemical binding]; other site 926562005673 oxyanion hole (OAH) forming residues; other site 926562005674 trimer interface [polypeptide binding]; other site 926562005675 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926562005676 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926562005677 catalytic residues [active] 926562005678 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 926562005679 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 926562005680 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 926562005681 Leucine rich repeat; Region: LRR_8; pfam13855 926562005682 Substrate binding site [chemical binding]; other site 926562005683 Leucine rich repeat; Region: LRR_8; pfam13855 926562005684 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 926562005685 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 926562005686 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 926562005687 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 926562005688 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 926562005689 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 926562005690 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 926562005691 FAD binding pocket [chemical binding]; other site 926562005692 FAD binding motif [chemical binding]; other site 926562005693 phosphate binding motif [ion binding]; other site 926562005694 beta-alpha-beta structure motif; other site 926562005695 NAD(p) ribose binding residues [chemical binding]; other site 926562005696 NAD binding pocket [chemical binding]; other site 926562005697 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 926562005698 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 926562005699 catalytic loop [active] 926562005700 iron binding site [ion binding]; other site 926562005701 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 926562005702 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926562005703 Coenzyme A binding pocket [chemical binding]; other site 926562005704 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 926562005705 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926562005706 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 926562005707 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926562005708 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926562005709 DNA binding residues [nucleotide binding] 926562005710 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005711 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 926562005712 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005713 ribonuclease R; Region: RNase_R; TIGR02063 926562005714 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 926562005715 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 926562005716 RNB domain; Region: RNB; pfam00773 926562005717 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 926562005718 RNA binding site [nucleotide binding]; other site 926562005719 Septum formation initiator; Region: DivIC; cl17659 926562005720 LysE type translocator; Region: LysE; cl00565 926562005721 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 926562005722 Zn binding site [ion binding]; other site 926562005723 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 926562005724 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 926562005725 active site 926562005726 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 926562005727 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 926562005728 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 926562005729 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 926562005730 Fic/DOC family; Region: Fic; cl00960 926562005731 hypothetical protein; Provisional; Region: PRK09897 926562005732 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 926562005733 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 926562005734 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 926562005735 CHRD domain; Region: CHRD; pfam07452 926562005736 CHRD domain; Region: CHRD; pfam07452 926562005737 CHRD domain; Region: CHRD; pfam07452 926562005738 CHRD domain; Region: CHRD; pfam07452 926562005739 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005740 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926562005741 dimerization interface [polypeptide binding]; other site 926562005742 putative DNA binding site [nucleotide binding]; other site 926562005743 putative Zn2+ binding site [ion binding]; other site 926562005744 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 926562005745 putative hydrophobic ligand binding site [chemical binding]; other site 926562005746 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 926562005747 dimer interface [polypeptide binding]; other site 926562005748 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 926562005749 putative hydrophobic ligand binding site [chemical binding]; other site 926562005750 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 926562005751 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_12; cd13142 926562005752 Protein of unknown function (DUF421); Region: DUF421; pfam04239 926562005753 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 926562005754 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 926562005755 dimer interface [polypeptide binding]; other site 926562005756 active site 926562005757 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 926562005758 substrate binding site [chemical binding]; other site 926562005759 catalytic residue [active] 926562005760 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 926562005761 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 926562005762 active site 926562005763 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 926562005764 dimer interface [polypeptide binding]; other site 926562005765 substrate binding site [chemical binding]; other site 926562005766 catalytic residues [active] 926562005767 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 926562005768 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 926562005769 metal binding site [ion binding]; metal-binding site 926562005770 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 926562005771 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926562005772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 926562005773 Coenzyme A binding pocket [chemical binding]; other site 926562005774 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 926562005775 Na binding site [ion binding]; other site 926562005776 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 926562005777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 926562005778 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 926562005779 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 926562005780 ADP-ribose binding site [chemical binding]; other site 926562005781 dimer interface [polypeptide binding]; other site 926562005782 active site 926562005783 nudix motif; other site 926562005784 metal binding site [ion binding]; metal-binding site 926562005785 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 926562005786 amidase catalytic site [active] 926562005787 Zn binding residues [ion binding]; other site 926562005788 substrate binding site [chemical binding]; other site 926562005789 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005790 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 926562005791 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 926562005792 dimerization interface [polypeptide binding]; other site 926562005793 DPS ferroxidase diiron center [ion binding]; other site 926562005794 ion pore; other site 926562005795 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 926562005796 RNA binding surface [nucleotide binding]; other site 926562005797 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 926562005798 hydroxyglutarate oxidase; Provisional; Region: PRK11728 926562005799 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 926562005800 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 926562005801 non-specific DNA binding site [nucleotide binding]; other site 926562005802 salt bridge; other site 926562005803 sequence-specific DNA binding site [nucleotide binding]; other site 926562005804 Cupin domain; Region: Cupin_2; pfam07883 926562005805 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 926562005806 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926562005807 motif II; other site 926562005808 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 926562005809 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926562005810 motif II; other site 926562005811 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926562005812 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562005813 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562005814 Interdomain contacts; other site 926562005815 Cytokine receptor motif; other site 926562005816 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926562005817 Anthrax toxin LF subunit; Region: Anthrax_toxA; pfam03497 926562005818 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005819 Uncharacterized conserved protein [Function unknown]; Region: COG3379 926562005820 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 926562005821 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005822 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562005823 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 926562005824 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562005825 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562005826 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 926562005827 DinB family; Region: DinB; cl17821 926562005828 Peptidase family M48; Region: Peptidase_M48; pfam01435 926562005829 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 926562005830 Cytochrome c; Region: Cytochrom_C; pfam00034 926562005831 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 926562005832 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 926562005833 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 926562005834 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562005835 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 926562005836 aldehyde dehydrogenase family 7 member; Region: PLN02315 926562005837 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 926562005838 tetrameric interface [polypeptide binding]; other site 926562005839 NAD binding site [chemical binding]; other site 926562005840 catalytic residues [active] 926562005841 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 926562005842 CCC1-related family of proteins; Region: CCC1_like; cl00278 926562005843 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 926562005844 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 926562005845 putative NAD(P) binding site [chemical binding]; other site 926562005846 putative active site [active] 926562005847 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 926562005848 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 926562005849 active site 926562005850 DNA binding site [nucleotide binding] 926562005851 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 926562005852 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 926562005853 active site 926562005854 catalytic tetrad [active] 926562005855 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926562005856 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 926562005857 homooctamer interface [polypeptide binding]; other site 926562005858 active site 926562005859 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 926562005860 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 926562005861 HIGH motif; other site 926562005862 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 926562005863 active site 926562005864 KMSKS motif; other site 926562005865 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 926562005866 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 926562005867 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 926562005868 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 926562005869 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 926562005870 Methyltransferase domain; Region: Methyltransf_23; pfam13489 926562005871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562005872 S-adenosylmethionine binding site [chemical binding]; other site 926562005873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 926562005874 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 926562005875 Phosphoglycerate kinase; Region: PGK; pfam00162 926562005876 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 926562005877 substrate binding site [chemical binding]; other site 926562005878 hinge regions; other site 926562005879 ADP binding site [chemical binding]; other site 926562005880 catalytic site [active] 926562005881 Colicin V production protein; Region: Colicin_V; pfam02674 926562005882 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 926562005883 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 926562005884 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 926562005885 dimer interface [polypeptide binding]; other site 926562005886 motif 1; other site 926562005887 active site 926562005888 motif 2; other site 926562005889 motif 3; other site 926562005890 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 926562005891 aromatic arch; other site 926562005892 DCoH dimer interaction site [polypeptide binding]; other site 926562005893 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 926562005894 DCoH tetramer interaction site [polypeptide binding]; other site 926562005895 substrate binding site [chemical binding]; other site 926562005896 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 926562005897 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 926562005898 domain interfaces; other site 926562005899 active site 926562005900 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 926562005901 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 926562005902 dimerization interface [polypeptide binding]; other site 926562005903 active site 926562005904 metal binding site [ion binding]; metal-binding site 926562005905 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 926562005906 dsRNA binding site [nucleotide binding]; other site 926562005907 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 926562005908 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 926562005909 dimer interface [polypeptide binding]; other site 926562005910 active site 926562005911 acyl carrier protein; Provisional; Region: acpP; PRK00982 926562005912 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 926562005913 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 926562005914 active site 926562005915 substrate binding site [chemical binding]; other site 926562005916 cosubstrate binding site; other site 926562005917 catalytic site [active] 926562005918 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 926562005919 RNA/DNA hybrid binding site [nucleotide binding]; other site 926562005920 active site 926562005921 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 926562005922 Peptidase family M23; Region: Peptidase_M23; pfam01551 926562005923 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562005924 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926562005925 Predicted permease; Region: DUF318; cl17795 926562005926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 926562005927 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 926562005928 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 926562005929 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 926562005930 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 926562005931 ATP synthase A chain; Region: ATP-synt_A; cl00413 926562005932 ATP synthase subunit C; Region: ATP-synt_C; cl00466 926562005933 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 926562005934 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 926562005935 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 926562005936 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 926562005937 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 926562005938 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 926562005939 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 926562005940 beta subunit interaction interface [polypeptide binding]; other site 926562005941 Walker A motif; other site 926562005942 ATP binding site [chemical binding]; other site 926562005943 Walker B motif; other site 926562005944 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 926562005945 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 926562005946 core domain interface [polypeptide binding]; other site 926562005947 delta subunit interface [polypeptide binding]; other site 926562005948 epsilon subunit interface [polypeptide binding]; other site 926562005949 Heme NO binding; Region: HNOB; pfam07700 926562005950 PAS domain S-box; Region: sensory_box; TIGR00229 926562005951 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926562005952 putative active site [active] 926562005953 heme pocket [chemical binding]; other site 926562005954 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 926562005955 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 926562005956 putative active site [active] 926562005957 heme pocket [chemical binding]; other site 926562005958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562005959 dimer interface [polypeptide binding]; other site 926562005960 phosphorylation site [posttranslational modification] 926562005961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562005962 ATP binding site [chemical binding]; other site 926562005963 Mg2+ binding site [ion binding]; other site 926562005964 G-X-G motif; other site 926562005965 Response regulator receiver domain; Region: Response_reg; pfam00072 926562005966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562005967 active site 926562005968 phosphorylation site [posttranslational modification] 926562005969 intermolecular recognition site; other site 926562005970 dimerization interface [polypeptide binding]; other site 926562005971 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 926562005972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562005973 active site 926562005974 phosphorylation site [posttranslational modification] 926562005975 intermolecular recognition site; other site 926562005976 dimerization interface [polypeptide binding]; other site 926562005977 LytTr DNA-binding domain; Region: LytTR; smart00850 926562005978 Response regulator receiver domain; Region: Response_reg; pfam00072 926562005979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562005980 active site 926562005981 phosphorylation site [posttranslational modification] 926562005982 intermolecular recognition site; other site 926562005983 dimerization interface [polypeptide binding]; other site 926562005984 HEAT repeats; Region: HEAT_2; pfam13646 926562005985 HEAT repeats; Region: HEAT_2; pfam13646 926562005986 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 926562005987 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 926562005988 DXD motif; other site 926562005989 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 926562005990 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 926562005991 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 926562005992 glutaminase active site [active] 926562005993 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 926562005994 dimer interface [polypeptide binding]; other site 926562005995 active site 926562005996 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 926562005997 dimer interface [polypeptide binding]; other site 926562005998 active site 926562005999 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 926562006000 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562006001 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 926562006002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926562006003 Coenzyme A binding pocket [chemical binding]; other site 926562006004 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562006005 HAMP domain; Region: HAMP; pfam00672 926562006006 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562006007 dimer interface [polypeptide binding]; other site 926562006008 phosphorylation site [posttranslational modification] 926562006009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562006010 ATP binding site [chemical binding]; other site 926562006011 Mg2+ binding site [ion binding]; other site 926562006012 G-X-G motif; other site 926562006013 Uncharacterized conserved protein [Function unknown]; Region: COG2968 926562006014 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 926562006015 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 926562006016 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 926562006017 substrate binding site [chemical binding]; other site 926562006018 oxyanion hole (OAH) forming residues; other site 926562006019 trimer interface [polypeptide binding]; other site 926562006020 Predicted esterase [General function prediction only]; Region: COG0400 926562006021 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 926562006022 RNA binding surface [nucleotide binding]; other site 926562006023 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 926562006024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562006025 active site 926562006026 phosphorylation site [posttranslational modification] 926562006027 intermolecular recognition site; other site 926562006028 dimerization interface [polypeptide binding]; other site 926562006029 LytTr DNA-binding domain; Region: LytTR; smart00850 926562006030 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 926562006031 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562006032 dimer interface [polypeptide binding]; other site 926562006033 phosphorylation site [posttranslational modification] 926562006034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562006035 ATP binding site [chemical binding]; other site 926562006036 Mg2+ binding site [ion binding]; other site 926562006037 G-X-G motif; other site 926562006038 Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946 926562006039 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 926562006040 substrate binding site [chemical binding]; other site 926562006041 ATP binding site [chemical binding]; other site 926562006042 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 926562006043 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926562006044 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926562006045 DNA binding residues [nucleotide binding] 926562006046 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926562006047 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 926562006048 carboxyltransferase (CT) interaction site; other site 926562006049 biotinylation site [posttranslational modification]; other site 926562006050 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 926562006051 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 926562006052 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 926562006053 active site 926562006054 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 926562006055 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 926562006056 protein binding site [polypeptide binding]; other site 926562006057 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 926562006058 putative substrate binding region [chemical binding]; other site 926562006059 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 926562006060 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 926562006061 ATP-dependent DNA ligase; Validated; Region: PRK09247 926562006062 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 926562006063 active site 926562006064 DNA binding site [nucleotide binding] 926562006065 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 926562006066 DNA binding site [nucleotide binding] 926562006067 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 926562006068 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926562006069 Coenzyme A binding pocket [chemical binding]; other site 926562006070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 926562006071 GldM C-terminal domain; Region: GldM_C; pfam12080 926562006072 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 926562006073 Helix-turn-helix domain; Region: HTH_18; pfam12833 926562006074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926562006075 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 926562006076 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 926562006077 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 926562006078 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 926562006079 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 926562006080 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 926562006081 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 926562006082 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 926562006083 ABC-ATPase subunit interface; other site 926562006084 dimer interface [polypeptide binding]; other site 926562006085 putative PBP binding regions; other site 926562006086 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 926562006087 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 926562006088 ABC-ATPase subunit interface; other site 926562006089 dimer interface [polypeptide binding]; other site 926562006090 putative PBP binding regions; other site 926562006091 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 926562006092 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 926562006093 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 926562006094 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 926562006095 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 926562006096 intersubunit interface [polypeptide binding]; other site 926562006097 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 926562006098 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 926562006099 FeoA domain; Region: FeoA; pfam04023 926562006100 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562006101 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 926562006102 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562006103 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 926562006104 putative active site [active] 926562006105 putative metal binding site [ion binding]; other site 926562006106 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 926562006107 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 926562006108 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 926562006109 Part of AAA domain; Region: AAA_19; pfam13245 926562006110 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 926562006111 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 926562006112 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 926562006113 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 926562006114 substrate-cofactor binding pocket; other site 926562006115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562006116 catalytic residue [active] 926562006117 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 926562006118 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 926562006119 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 926562006120 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 926562006121 dimer interface [polypeptide binding]; other site 926562006122 active site 926562006123 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 926562006124 catalytic residues [active] 926562006125 substrate binding site [chemical binding]; other site 926562006126 deoxyhypusine synthase; Region: dhys; TIGR00321 926562006127 Deoxyhypusine synthase; Region: DS; cl00826 926562006128 Deoxyhypusine synthase; Region: DS; cl00826 926562006129 methionine sulfoxide reductase A; Provisional; Region: PRK14054 926562006130 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 926562006131 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 926562006132 Bacterial Ig-like domain; Region: Big_5; pfam13205 926562006133 Lamin Tail Domain; Region: LTD; pfam00932 926562006134 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 926562006135 agmatinase; Region: agmatinase; TIGR01230 926562006136 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 926562006137 putative active site [active] 926562006138 Mn binding site [ion binding]; other site 926562006139 DNA topoisomerase III; Provisional; Region: PRK07726 926562006140 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 926562006141 active site 926562006142 putative interdomain interaction site [polypeptide binding]; other site 926562006143 putative metal-binding site [ion binding]; other site 926562006144 putative nucleotide binding site [chemical binding]; other site 926562006145 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 926562006146 domain I; other site 926562006147 DNA binding groove [nucleotide binding] 926562006148 phosphate binding site [ion binding]; other site 926562006149 domain II; other site 926562006150 domain III; other site 926562006151 nucleotide binding site [chemical binding]; other site 926562006152 catalytic site [active] 926562006153 domain IV; other site 926562006154 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 926562006155 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 926562006156 active site 926562006157 catalytic site [active] 926562006158 substrate binding site [chemical binding]; other site 926562006159 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 926562006160 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 926562006161 Walker A/P-loop; other site 926562006162 ATP binding site [chemical binding]; other site 926562006163 Q-loop/lid; other site 926562006164 ABC transporter signature motif; other site 926562006165 Walker B; other site 926562006166 D-loop; other site 926562006167 H-loop/switch region; other site 926562006168 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 926562006169 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 926562006170 Walker A/P-loop; other site 926562006171 ATP binding site [chemical binding]; other site 926562006172 Q-loop/lid; other site 926562006173 ABC transporter signature motif; other site 926562006174 Walker B; other site 926562006175 D-loop; other site 926562006176 H-loop/switch region; other site 926562006177 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 926562006178 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 926562006179 putative diguanylate cyclase; Provisional; Region: PRK09776 926562006180 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 926562006181 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 926562006182 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 926562006183 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 926562006184 Transglycosylase; Region: Transgly; pfam00912 926562006185 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 926562006186 GldH lipoprotein; Region: GldH_lipo; pfam14109 926562006187 PSP1 C-terminal conserved region; Region: PSP1; cl00770 926562006188 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562006189 Recombination protein O N terminal; Region: RecO_N; pfam11967 926562006190 Recombination protein O C terminal; Region: RecO_C; pfam02565 926562006191 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562006192 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 926562006193 N-acetyl-D-glucosamine binding site [chemical binding]; other site 926562006194 catalytic residue [active] 926562006195 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926562006196 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 926562006197 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 926562006198 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 926562006199 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 926562006200 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926562006201 Sulfatase; Region: Sulfatase; pfam00884 926562006202 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 926562006203 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 926562006204 Beta-lactamase; Region: Beta-lactamase; pfam00144 926562006205 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 926562006206 BNR repeat-like domain; Region: BNR_2; pfam13088 926562006207 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 926562006208 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562006209 Protein of unknown function DUF262; Region: DUF262; pfam03235 926562006210 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 926562006211 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 926562006212 active site 926562006213 catalytic residues [active] 926562006214 metal binding site [ion binding]; metal-binding site 926562006215 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 926562006216 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 926562006217 substrate binding site [chemical binding]; other site 926562006218 ligand binding site [chemical binding]; other site 926562006219 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 926562006220 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 926562006221 substrate binding site [chemical binding]; other site 926562006222 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 926562006223 tartrate dehydrogenase; Region: TTC; TIGR02089 926562006224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562006225 S-adenosylmethionine binding site [chemical binding]; other site 926562006226 Methyltransferase domain; Region: Methyltransf_23; pfam13489 926562006227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926562006228 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 926562006229 Coenzyme A binding pocket [chemical binding]; other site 926562006230 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926562006231 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 926562006232 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 926562006233 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 926562006234 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 926562006235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 926562006236 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 926562006237 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 926562006238 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926562006239 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926562006240 DNA binding site [nucleotide binding] 926562006241 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 926562006242 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926562006243 putative catalytic residue [active] 926562006244 thioredoxin 2; Provisional; Region: PRK10996 926562006245 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926562006246 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926562006247 catalytic residues [active] 926562006248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926562006249 putative substrate translocation pore; other site 926562006250 MepB protein; Region: MepB; pfam08877 926562006251 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 926562006252 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 926562006253 active site 926562006254 metal binding site [ion binding]; metal-binding site 926562006255 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926562006256 dimerization interface [polypeptide binding]; other site 926562006257 putative DNA binding site [nucleotide binding]; other site 926562006258 putative Zn2+ binding site [ion binding]; other site 926562006259 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 926562006260 classical (c) SDRs; Region: SDR_c; cd05233 926562006261 NAD(P) binding site [chemical binding]; other site 926562006262 active site 926562006263 GXWXG protein; Region: GXWXG; pfam14231 926562006264 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 926562006265 short chain dehydrogenase; Provisional; Region: PRK06172 926562006266 classical (c) SDRs; Region: SDR_c; cd05233 926562006267 NAD(P) binding site [chemical binding]; other site 926562006268 active site 926562006269 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926562006270 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 926562006271 ligand binding site [chemical binding]; other site 926562006272 flexible hinge region; other site 926562006273 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 926562006274 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 926562006275 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 926562006276 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562006277 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562006278 dimer interface [polypeptide binding]; other site 926562006279 phosphorylation site [posttranslational modification] 926562006280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562006281 ATP binding site [chemical binding]; other site 926562006282 Mg2+ binding site [ion binding]; other site 926562006283 G-X-G motif; other site 926562006284 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 926562006285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562006286 active site 926562006287 phosphorylation site [posttranslational modification] 926562006288 intermolecular recognition site; other site 926562006289 dimerization interface [polypeptide binding]; other site 926562006290 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 926562006291 DNA binding site [nucleotide binding] 926562006292 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 926562006293 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 926562006294 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 926562006295 HlyD family secretion protein; Region: HlyD_3; pfam13437 926562006296 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 926562006297 MarR family; Region: MarR_2; pfam12802 926562006298 short chain dehydrogenase; Provisional; Region: PRK12939 926562006299 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 926562006300 NADP binding site [chemical binding]; other site 926562006301 homodimer interface [polypeptide binding]; other site 926562006302 active site 926562006303 substrate binding site [chemical binding]; other site 926562006304 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 926562006305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926562006306 motif II; other site 926562006307 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926562006308 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 926562006309 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 926562006310 DNA-binding site [nucleotide binding]; DNA binding site 926562006311 RNA-binding motif; other site 926562006312 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562006313 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562006314 Histidine kinase; Region: His_kinase; pfam06580 926562006315 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 926562006316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562006317 active site 926562006318 phosphorylation site [posttranslational modification] 926562006319 intermolecular recognition site; other site 926562006320 dimerization interface [polypeptide binding]; other site 926562006321 LytTr DNA-binding domain; Region: LytTR; smart00850 926562006322 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 926562006323 KWG Leptospira; Region: KWG; pfam07656 926562006324 GH3 auxin-responsive promoter; Region: GH3; pfam03321 926562006325 Uncharacterized conserved protein [Function unknown]; Region: COG1262 926562006326 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 926562006327 Low molecular weight phosphatase family; Region: LMWPc; cl00105 926562006328 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 926562006329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 926562006330 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 926562006331 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562006332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562006333 binding surface 926562006334 TPR motif; other site 926562006335 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562006336 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562006337 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 926562006338 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 926562006339 N-terminal plug; other site 926562006340 ligand-binding site [chemical binding]; other site 926562006341 Phytase; Region: Phytase; cl17685 926562006342 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 926562006343 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 926562006344 putative NAD(P) binding site [chemical binding]; other site 926562006345 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 926562006346 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 926562006347 inhibitor-cofactor binding pocket; inhibition site 926562006348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562006349 catalytic residue [active] 926562006350 Predicted amidohydrolase [General function prediction only]; Region: COG0388 926562006351 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 926562006352 active site 926562006353 catalytic triad [active] 926562006354 dimer interface [polypeptide binding]; other site 926562006355 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 926562006356 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 926562006357 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 926562006358 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926562006359 catalytic residue [active] 926562006360 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 926562006361 biotin carboxylase-like protein; Validated; Region: PRK06524 926562006362 ATP-grasp domain; Region: ATP-grasp_4; cl17255 926562006363 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 926562006364 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 926562006365 NAD(P) binding site [chemical binding]; other site 926562006366 catalytic residues [active] 926562006367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 926562006368 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 926562006369 active site 926562006370 metal binding site [ion binding]; metal-binding site 926562006371 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926562006372 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926562006373 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562006374 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 926562006375 Peptidase family M23; Region: Peptidase_M23; pfam01551 926562006376 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 926562006377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562006378 binding surface 926562006379 TPR repeat; Region: TPR_11; pfam13414 926562006380 TPR motif; other site 926562006381 Tetratricopeptide repeat; Region: TPR_16; pfam13432 926562006382 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562006383 binding surface 926562006384 TPR motif; other site 926562006385 TPR repeat; Region: TPR_11; pfam13414 926562006386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562006387 binding surface 926562006388 TPR repeat; Region: TPR_11; pfam13414 926562006389 TPR motif; other site 926562006390 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 926562006391 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 926562006392 active site 926562006393 Substrate binding site; other site 926562006394 Mg++ binding site; other site 926562006395 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 926562006396 dimer interface [polypeptide binding]; other site 926562006397 N-terminal domain interface [polypeptide binding]; other site 926562006398 Transposase IS200 like; Region: Y1_Tnp; cl00848 926562006399 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 926562006400 trimer interface [polypeptide binding]; other site 926562006401 active site 926562006402 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 926562006403 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 926562006404 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 926562006405 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 926562006406 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 926562006407 Peptidase family M28; Region: Peptidase_M28; pfam04389 926562006408 metal binding site [ion binding]; metal-binding site 926562006409 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 926562006410 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 926562006411 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 926562006412 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 926562006413 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 926562006414 Histidine kinase; Region: His_kinase; pfam06580 926562006415 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 926562006416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562006417 active site 926562006418 phosphorylation site [posttranslational modification] 926562006419 intermolecular recognition site; other site 926562006420 dimerization interface [polypeptide binding]; other site 926562006421 LytTr DNA-binding domain; Region: LytTR; smart00850 926562006422 Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144 926562006423 putative FMN binding site [chemical binding]; other site 926562006424 putative dimer interface [polypeptide binding]; other site 926562006425 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926562006426 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 926562006427 ligand binding site [chemical binding]; other site 926562006428 flexible hinge region; other site 926562006429 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 926562006430 non-specific DNA interactions [nucleotide binding]; other site 926562006431 DNA binding site [nucleotide binding] 926562006432 sequence specific DNA binding site [nucleotide binding]; other site 926562006433 putative cAMP binding site [chemical binding]; other site 926562006434 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 926562006435 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 926562006436 nucleophile elbow; other site 926562006437 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 926562006438 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 926562006439 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 926562006440 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 926562006441 GIY-YIG motif/motif A; other site 926562006442 active site 926562006443 catalytic site [active] 926562006444 putative DNA binding site [nucleotide binding]; other site 926562006445 metal binding site [ion binding]; metal-binding site 926562006446 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 926562006447 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 926562006448 active site 926562006449 8-oxo-dGMP binding site [chemical binding]; other site 926562006450 nudix motif; other site 926562006451 metal binding site [ion binding]; metal-binding site 926562006452 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 926562006453 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 926562006454 active site 926562006455 metal binding site [ion binding]; metal-binding site 926562006456 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926562006457 Beta-lactamase; Region: Beta-lactamase; pfam00144 926562006458 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 926562006459 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 926562006460 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 926562006461 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017 926562006462 dimer interface [polypeptide binding]; other site 926562006463 active site 926562006464 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 926562006465 dimer interface [polypeptide binding]; other site 926562006466 active site 926562006467 Predicted transcriptional regulators [Transcription]; Region: COG1695 926562006468 Transcriptional regulator PadR-like family; Region: PadR; cl17335 926562006469 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562006470 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 926562006471 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926562006472 Coenzyme A binding pocket [chemical binding]; other site 926562006473 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926562006474 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926562006475 catalytic residues [active] 926562006476 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 926562006477 lipoprotein signal peptidase; Provisional; Region: PRK14787 926562006478 lipoprotein signal peptidase; Provisional; Region: PRK14788 926562006479 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 926562006480 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 926562006481 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 926562006482 active site 926562006483 HIGH motif; other site 926562006484 nucleotide binding site [chemical binding]; other site 926562006485 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 926562006486 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 926562006487 active site 926562006488 KMSKS motif; other site 926562006489 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 926562006490 tRNA binding surface [nucleotide binding]; other site 926562006491 anticodon binding site; other site 926562006492 RibD C-terminal domain; Region: RibD_C; cl17279 926562006493 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 926562006494 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 926562006495 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 926562006496 substrate binding pocket [chemical binding]; other site 926562006497 Ion channel; Region: Ion_trans_2; pfam07885 926562006498 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 926562006499 membrane-bound complex binding site; other site 926562006500 hinge residues; other site 926562006501 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 926562006502 PhoD-like phosphatase; Region: PhoD; pfam09423 926562006503 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 926562006504 putative active site [active] 926562006505 putative metal binding site [ion binding]; other site 926562006506 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 926562006507 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562006508 Calx-beta domain; Region: Calx-beta; cl02522 926562006509 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 926562006510 generic binding surface II; other site 926562006511 generic binding surface I; other site 926562006512 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562006513 AAA ATPase domain; Region: AAA_16; pfam13191 926562006514 AAA domain; Region: AAA_22; pfam13401 926562006515 Walker A motif; other site 926562006516 ATP binding site [chemical binding]; other site 926562006517 Walker B motif; other site 926562006518 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562006519 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 926562006520 homotrimer interaction site [polypeptide binding]; other site 926562006521 putative active site [active] 926562006522 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562006523 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 926562006524 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926562006525 Zn2+ binding site [ion binding]; other site 926562006526 Mg2+ binding site [ion binding]; other site 926562006527 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 926562006528 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 926562006529 TrkA-N domain; Region: TrkA_N; pfam02254 926562006530 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 926562006531 Low molecular weight phosphatase family; Region: LMWPc; cd00115 926562006532 active site 926562006533 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 926562006534 arsenical-resistance protein; Region: acr3; TIGR00832 926562006535 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 926562006536 dimerization interface [polypeptide binding]; other site 926562006537 putative DNA binding site [nucleotide binding]; other site 926562006538 putative Zn2+ binding site [ion binding]; other site 926562006539 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 926562006540 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 926562006541 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 926562006542 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 926562006543 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 926562006544 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 926562006545 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 926562006546 homodimer interface [polypeptide binding]; other site 926562006547 substrate-cofactor binding pocket; other site 926562006548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562006549 catalytic residue [active] 926562006550 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 926562006551 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 926562006552 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926562006553 nucleotide binding region [chemical binding]; other site 926562006554 ATP-binding site [chemical binding]; other site 926562006555 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 926562006556 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926562006557 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926562006558 DNA binding residues [nucleotide binding] 926562006559 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926562006560 Protein of unknown function, DUF547; Region: DUF547; pfam04784 926562006561 methionine aminotransferase; Validated; Region: PRK09082 926562006562 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 926562006563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562006564 homodimer interface [polypeptide binding]; other site 926562006565 catalytic residue [active] 926562006566 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 926562006567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926562006568 Walker A/P-loop; other site 926562006569 ATP binding site [chemical binding]; other site 926562006570 Q-loop/lid; other site 926562006571 ABC transporter signature motif; other site 926562006572 Walker B; other site 926562006573 D-loop; other site 926562006574 H-loop/switch region; other site 926562006575 ABC transporter; Region: ABC_tran_2; pfam12848 926562006576 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926562006577 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926562006578 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926562006579 Walker A/P-loop; other site 926562006580 ATP binding site [chemical binding]; other site 926562006581 Q-loop/lid; other site 926562006582 ABC transporter signature motif; other site 926562006583 Walker B; other site 926562006584 D-loop; other site 926562006585 H-loop/switch region; other site 926562006586 short chain dehydrogenase; Provisional; Region: PRK08339 926562006587 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 926562006588 putative NAD(P) binding site [chemical binding]; other site 926562006589 putative active site [active] 926562006590 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 926562006591 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 926562006592 NAD binding site [chemical binding]; other site 926562006593 catalytic residues [active] 926562006594 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 926562006595 putative ADP-ribose binding site [chemical binding]; other site 926562006596 putative active site [active] 926562006597 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 926562006598 Beta-lactamase; Region: Beta-lactamase; pfam00144 926562006599 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562006600 RmuC family; Region: RmuC; pfam02646 926562006601 MarC family integral membrane protein; Region: MarC; pfam01914 926562006602 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 926562006603 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 926562006604 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 926562006605 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 926562006606 active site 926562006607 catalytic residues [active] 926562006608 CARDB; Region: CARDB; pfam07705 926562006609 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562006610 Right handed beta helix region; Region: Beta_helix; pfam13229 926562006611 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562006612 Interdomain contacts; other site 926562006613 Cytokine receptor motif; other site 926562006614 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562006615 TPR repeat; Region: TPR_11; pfam13414 926562006616 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562006617 binding surface 926562006618 TPR motif; other site 926562006619 Bacterial SH3 domain homologues; Region: SH3b; smart00287 926562006620 Oxygen tolerance; Region: BatD; pfam13584 926562006621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562006622 binding surface 926562006623 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 926562006624 TPR motif; other site 926562006625 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 926562006626 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 926562006627 metal ion-dependent adhesion site (MIDAS); other site 926562006628 Aerotolerance regulator N-terminal; Region: BatA; cl06567 926562006629 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 926562006630 metal ion-dependent adhesion site (MIDAS); other site 926562006631 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 926562006632 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 926562006633 metal ion-dependent adhesion site (MIDAS); other site 926562006634 MoxR-like ATPases [General function prediction only]; Region: COG0714 926562006635 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 926562006636 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 926562006637 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562006638 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 926562006639 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 926562006640 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562006641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562006642 dimer interface [polypeptide binding]; other site 926562006643 phosphorylation site [posttranslational modification] 926562006644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562006645 ATP binding site [chemical binding]; other site 926562006646 Mg2+ binding site [ion binding]; other site 926562006647 G-X-G motif; other site 926562006648 Response regulator receiver domain; Region: Response_reg; pfam00072 926562006649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562006650 active site 926562006651 phosphorylation site [posttranslational modification] 926562006652 intermolecular recognition site; other site 926562006653 dimerization interface [polypeptide binding]; other site 926562006654 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 926562006655 putative active site [active] 926562006656 putative metal binding site [ion binding]; other site 926562006657 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 926562006658 Peptidase S46; Region: Peptidase_S46; pfam10459 926562006659 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 926562006660 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 926562006661 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 926562006662 active site 926562006663 Amidohydrolase; Region: Amidohydro_2; pfam04909 926562006664 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 926562006665 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 926562006666 Active Sites [active] 926562006667 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 926562006668 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 926562006669 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926562006670 ATP binding site [chemical binding]; other site 926562006671 putative Mg++ binding site [ion binding]; other site 926562006672 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926562006673 nucleotide binding region [chemical binding]; other site 926562006674 ATP-binding site [chemical binding]; other site 926562006675 DEAD/H associated; Region: DEAD_assoc; pfam08494 926562006676 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 926562006677 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 926562006678 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 926562006679 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 926562006680 Cu(I) binding site [ion binding]; other site 926562006681 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 926562006682 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 926562006683 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 926562006684 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 926562006685 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 926562006686 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 926562006687 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 926562006688 catalytic residue [active] 926562006689 FeS assembly protein SufD; Region: sufD; TIGR01981 926562006690 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 926562006691 FeS assembly ATPase SufC; Region: sufC; TIGR01978 926562006692 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 926562006693 Walker A/P-loop; other site 926562006694 ATP binding site [chemical binding]; other site 926562006695 Q-loop/lid; other site 926562006696 ABC transporter signature motif; other site 926562006697 Walker B; other site 926562006698 D-loop; other site 926562006699 H-loop/switch region; other site 926562006700 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 926562006701 putative ABC transporter; Region: ycf24; CHL00085 926562006702 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 926562006703 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562006704 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562006705 thiamine-monophosphate kinase; Region: thiL; TIGR01379 926562006706 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 926562006707 ATP binding site [chemical binding]; other site 926562006708 dimerization interface [polypeptide binding]; other site 926562006709 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 926562006710 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 926562006711 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 926562006712 proline aminopeptidase P II; Provisional; Region: PRK10879 926562006713 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 926562006714 active site 926562006715 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 926562006716 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 926562006717 putative Iron-sulfur protein interface [polypeptide binding]; other site 926562006718 proximal heme binding site [chemical binding]; other site 926562006719 distal heme binding site [chemical binding]; other site 926562006720 putative dimer interface [polypeptide binding]; other site 926562006721 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 926562006722 L-aspartate oxidase; Provisional; Region: PRK06175 926562006723 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 926562006724 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 926562006725 four helix bundle protein; Region: TIGR02436 926562006726 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 926562006727 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 926562006728 C-N hydrolase family amidase; Provisional; Region: PRK10438 926562006729 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 926562006730 putative active site [active] 926562006731 catalytic triad [active] 926562006732 dimer interface [polypeptide binding]; other site 926562006733 multimer interface [polypeptide binding]; other site 926562006734 Bacterial Ig-like domain; Region: Big_5; pfam13205 926562006735 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 926562006736 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926562006737 active site 926562006738 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268 926562006739 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 926562006740 putative active site [active] 926562006741 putative catalytic site [active] 926562006742 putative DNA binding site [nucleotide binding]; other site 926562006743 putative phosphate binding site [ion binding]; other site 926562006744 metal binding site A [ion binding]; metal-binding site 926562006745 putative AP binding site [nucleotide binding]; other site 926562006746 putative metal binding site B [ion binding]; other site 926562006747 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926562006748 ligand binding site [chemical binding]; other site 926562006749 Transposase IS200 like; Region: Y1_Tnp; pfam01797 926562006750 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 926562006751 Fasciclin domain; Region: Fasciclin; cl02663 926562006752 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 926562006753 DNA repair protein RadA; Provisional; Region: PRK11823 926562006754 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 926562006755 Walker A motif/ATP binding site; other site 926562006756 ATP binding site [chemical binding]; other site 926562006757 Walker B motif; other site 926562006758 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 926562006759 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562006760 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 926562006761 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926562006762 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562006763 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 926562006764 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 926562006765 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 926562006766 dimerization interface [polypeptide binding]; other site 926562006767 ATP binding site [chemical binding]; other site 926562006768 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 926562006769 dimerization interface [polypeptide binding]; other site 926562006770 ATP binding site [chemical binding]; other site 926562006771 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 926562006772 putative active site [active] 926562006773 catalytic triad [active] 926562006774 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 926562006775 DNA-binding site [nucleotide binding]; DNA binding site 926562006776 RNA-binding motif; other site 926562006777 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 926562006778 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926562006779 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926562006780 ABC transporter; Region: ABC_tran_2; pfam12848 926562006781 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926562006782 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 926562006783 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 926562006784 tetramerization interface [polypeptide binding]; other site 926562006785 active site 926562006786 Pantoate-beta-alanine ligase; Region: PanC; cd00560 926562006787 pantoate--beta-alanine ligase; Region: panC; TIGR00018 926562006788 active site 926562006789 ATP-binding site [chemical binding]; other site 926562006790 pantoate-binding site; other site 926562006791 HXXH motif; other site 926562006792 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 926562006793 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 926562006794 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 926562006795 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 926562006796 glutaminase active site [active] 926562006797 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 926562006798 dimer interface [polypeptide binding]; other site 926562006799 active site 926562006800 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 926562006801 dimer interface [polypeptide binding]; other site 926562006802 active site 926562006803 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 926562006804 putative active site [active] 926562006805 catalytic residue [active] 926562006806 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 926562006807 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 926562006808 5S rRNA interface [nucleotide binding]; other site 926562006809 CTC domain interface [polypeptide binding]; other site 926562006810 L16 interface [polypeptide binding]; other site 926562006811 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 926562006812 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 926562006813 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926562006814 active site 926562006815 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 926562006816 catalytic motif [active] 926562006817 Zn binding site [ion binding]; other site 926562006818 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 926562006819 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 926562006820 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 926562006821 protein binding site [polypeptide binding]; other site 926562006822 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 926562006823 Catalytic dyad [active] 926562006824 glycyl-tRNA synthetase; Provisional; Region: PRK04173 926562006825 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 926562006826 motif 1; other site 926562006827 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 926562006828 active site 926562006829 motif 2; other site 926562006830 motif 3; other site 926562006831 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 926562006832 anticodon binding site; other site 926562006833 FG-GAP repeat; Region: FG-GAP_2; pfam14312 926562006834 FG-GAP repeat; Region: FG-GAP_2; pfam14312 926562006835 FG-GAP repeat; Region: FG-GAP_2; pfam14312 926562006836 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 926562006837 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 926562006838 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 926562006839 dimer interface [polypeptide binding]; other site 926562006840 putative radical transfer pathway; other site 926562006841 diiron center [ion binding]; other site 926562006842 tyrosyl radical; other site 926562006843 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 926562006844 ATP cone domain; Region: ATP-cone; pfam03477 926562006845 Class I ribonucleotide reductase; Region: RNR_I; cd01679 926562006846 active site 926562006847 dimer interface [polypeptide binding]; other site 926562006848 catalytic residues [active] 926562006849 effector binding site; other site 926562006850 R2 peptide binding site; other site 926562006851 hypothetical protein; Provisional; Region: PRK08262 926562006852 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 926562006853 metal binding site [ion binding]; metal-binding site 926562006854 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 926562006855 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 926562006856 active site 926562006857 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 926562006858 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 926562006859 active site 926562006860 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 926562006861 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 926562006862 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 926562006863 active site 926562006864 ribonuclease P; Reviewed; Region: rnpA; PRK01903 926562006865 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 926562006866 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 926562006867 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 926562006868 protein binding site [polypeptide binding]; other site 926562006869 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 926562006870 Catalytic dyad [active] 926562006871 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 926562006872 O-Antigen ligase; Region: Wzy_C; pfam04932 926562006873 DNA primase, catalytic core; Region: dnaG; TIGR01391 926562006874 CHC2 zinc finger; Region: zf-CHC2; pfam01807 926562006875 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 926562006876 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 926562006877 active site 926562006878 metal binding site [ion binding]; metal-binding site 926562006879 interdomain interaction site; other site 926562006880 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 926562006881 Mechanosensitive ion channel; Region: MS_channel; pfam00924 926562006882 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 926562006883 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 926562006884 substrate binding pocket [chemical binding]; other site 926562006885 chain length determination region; other site 926562006886 substrate-Mg2+ binding site; other site 926562006887 catalytic residues [active] 926562006888 aspartate-rich region 1; other site 926562006889 active site lid residues [active] 926562006890 aspartate-rich region 2; other site 926562006891 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 926562006892 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926562006893 FeS/SAM binding site; other site 926562006894 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 926562006895 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 926562006896 active site 926562006897 PAS domain; Region: PAS; smart00091 926562006898 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 926562006899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562006900 ATP binding site [chemical binding]; other site 926562006901 Mg2+ binding site [ion binding]; other site 926562006902 G-X-G motif; other site 926562006903 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 926562006904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562006905 active site 926562006906 phosphorylation site [posttranslational modification] 926562006907 intermolecular recognition site; other site 926562006908 dimerization interface [polypeptide binding]; other site 926562006909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562006910 Walker A motif; other site 926562006911 ATP binding site [chemical binding]; other site 926562006912 Walker B motif; other site 926562006913 arginine finger; other site 926562006914 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 926562006915 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926562006916 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926562006917 Walker A/P-loop; other site 926562006918 ATP binding site [chemical binding]; other site 926562006919 Q-loop/lid; other site 926562006920 ABC transporter signature motif; other site 926562006921 Walker B; other site 926562006922 D-loop; other site 926562006923 H-loop/switch region; other site 926562006924 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926562006925 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926562006926 FtsX-like permease family; Region: FtsX; pfam02687 926562006927 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 926562006928 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 926562006929 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 926562006930 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 926562006931 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 926562006932 active site 926562006933 Zn binding site [ion binding]; other site 926562006934 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 926562006935 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 926562006936 active site 926562006937 catalytic residues [active] 926562006938 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 926562006939 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 926562006940 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 926562006941 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 926562006942 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 926562006943 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 926562006944 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 926562006945 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 926562006946 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 926562006947 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562006948 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 926562006949 active site residue [active] 926562006950 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 926562006951 active site residue [active] 926562006952 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 926562006953 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926562006954 catalytic residues [active] 926562006955 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 926562006956 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 926562006957 NodB motif; other site 926562006958 active site 926562006959 catalytic site [active] 926562006960 metal binding site [ion binding]; metal-binding site 926562006961 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 926562006962 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562006963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562006964 dimer interface [polypeptide binding]; other site 926562006965 phosphorylation site [posttranslational modification] 926562006966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562006967 ATP binding site [chemical binding]; other site 926562006968 Mg2+ binding site [ion binding]; other site 926562006969 G-X-G motif; other site 926562006970 Response regulator receiver domain; Region: Response_reg; pfam00072 926562006971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562006972 active site 926562006973 phosphorylation site [posttranslational modification] 926562006974 intermolecular recognition site; other site 926562006975 dimerization interface [polypeptide binding]; other site 926562006976 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 926562006977 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 926562006978 active site 926562006979 HIGH motif; other site 926562006980 nucleotide binding site [chemical binding]; other site 926562006981 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 926562006982 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 926562006983 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 926562006984 active site 926562006985 KMSKS motif; other site 926562006986 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 926562006987 tRNA binding surface [nucleotide binding]; other site 926562006988 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 926562006989 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 926562006990 putative peptidase; Provisional; Region: PRK11649 926562006991 Peptidase family M23; Region: Peptidase_M23; pfam01551 926562006992 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 926562006993 DHH family; Region: DHH; pfam01368 926562006994 DHHA1 domain; Region: DHHA1; pfam02272 926562006995 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 926562006996 Ligand Binding Site [chemical binding]; other site 926562006997 Universal stress protein family; Region: Usp; pfam00582 926562006998 Ligand Binding Site [chemical binding]; other site 926562006999 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 926562007000 Malic enzyme, N-terminal domain; Region: malic; pfam00390 926562007001 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 926562007002 putative NAD(P) binding site [chemical binding]; other site 926562007003 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 926562007004 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 926562007005 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 926562007006 HflX GTPase family; Region: HflX; cd01878 926562007007 G1 box; other site 926562007008 GTP/Mg2+ binding site [chemical binding]; other site 926562007009 Switch I region; other site 926562007010 G2 box; other site 926562007011 G3 box; other site 926562007012 Switch II region; other site 926562007013 G4 box; other site 926562007014 G5 box; other site 926562007015 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 926562007016 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 926562007017 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 926562007018 active site 926562007019 dimer interface [polypeptide binding]; other site 926562007020 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 926562007021 dimer interface [polypeptide binding]; other site 926562007022 active site 926562007023 Fatty acid desaturase; Region: FA_desaturase; pfam00487 926562007024 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 926562007025 putative di-iron ligands [ion binding]; other site 926562007026 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 926562007027 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 926562007028 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 926562007029 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 926562007030 trimer interface [polypeptide binding]; other site 926562007031 putative metal binding site [ion binding]; other site 926562007032 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 926562007033 active site triad [active] 926562007034 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562007035 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 926562007036 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 926562007037 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 926562007038 RNA binding surface [nucleotide binding]; other site 926562007039 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 926562007040 active site 926562007041 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 926562007042 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 926562007043 dimer interface [polypeptide binding]; other site 926562007044 catalytic triad [active] 926562007045 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 926562007046 active site 926562007047 hydrophilic channel; other site 926562007048 dimerization interface [polypeptide binding]; other site 926562007049 catalytic residues [active] 926562007050 active site lid [active] 926562007051 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 926562007052 FOG: CBS domain [General function prediction only]; Region: COG0517 926562007053 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 926562007054 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 926562007055 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 926562007056 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 926562007057 catalytic residue [active] 926562007058 putative FPP diphosphate binding site; other site 926562007059 putative FPP binding hydrophobic cleft; other site 926562007060 dimer interface [polypeptide binding]; other site 926562007061 putative IPP diphosphate binding site; other site 926562007062 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 926562007063 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 926562007064 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 926562007065 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 926562007066 Surface antigen; Region: Bac_surface_Ag; pfam01103 926562007067 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 926562007068 periplasmic chaperone; Provisional; Region: PRK10780 926562007069 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 926562007070 glutamate racemase; Provisional; Region: PRK00865 926562007071 PGAP1-like protein; Region: PGAP1; pfam07819 926562007072 acyl-CoA esterase; Provisional; Region: PRK10673 926562007073 Outer membrane efflux protein; Region: OEP; pfam02321 926562007074 Outer membrane efflux protein; Region: OEP; pfam02321 926562007075 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 926562007076 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 926562007077 HlyD family secretion protein; Region: HlyD_3; pfam13437 926562007078 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 926562007079 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 926562007080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926562007081 Walker A/P-loop; other site 926562007082 ATP binding site [chemical binding]; other site 926562007083 Q-loop/lid; other site 926562007084 ABC transporter signature motif; other site 926562007085 Walker B; other site 926562007086 D-loop; other site 926562007087 H-loop/switch region; other site 926562007088 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 926562007089 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 926562007090 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 926562007091 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 926562007092 active site 926562007093 HIGH motif; other site 926562007094 KMSKS motif; other site 926562007095 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 926562007096 tRNA binding surface [nucleotide binding]; other site 926562007097 anticodon binding site; other site 926562007098 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 926562007099 dimer interface [polypeptide binding]; other site 926562007100 putative tRNA-binding site [nucleotide binding]; other site 926562007101 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562007102 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 926562007103 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926562007104 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926562007105 ABC transporter; Region: ABC_tran_2; pfam12848 926562007106 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 926562007107 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926562007108 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926562007109 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926562007110 intermolecular salt bridges; other site 926562007111 calcium mediated ligand binding site; other site 926562007112 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 926562007113 putative active site [active] 926562007114 putative metal binding site [ion binding]; other site 926562007115 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562007116 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 926562007117 Phage Tail Collar Domain; Region: Collar; pfam07484 926562007118 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cd00037 926562007119 ligand binding surface [chemical binding]; other site 926562007120 HYR domain; Region: HYR; pfam02494 926562007121 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562007122 Right handed beta helix region; Region: Beta_helix; pfam13229 926562007123 Right handed beta helix region; Region: Beta_helix; pfam13229 926562007124 CARDB; Region: CARDB; pfam07705 926562007125 CARDB; Region: CARDB; pfam07705 926562007126 CARDB; Region: CARDB; pfam07705 926562007127 CARDB; Region: CARDB; pfam07705 926562007128 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 926562007129 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562007130 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 926562007131 putative active site [active] 926562007132 putative catalytic triad [active] 926562007133 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 926562007134 catalytic residues [active] 926562007135 Lamin Tail Domain; Region: LTD; pfam00932 926562007136 Lamin Tail Domain; Region: LTD; pfam00932 926562007137 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562007138 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 926562007139 gliding motility associated protien GldN; Region: GldN; TIGR03523 926562007140 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 926562007141 GldM N-terminal domain; Region: GldM_N; pfam12081 926562007142 GldM C-terminal domain; Region: GldM_C; pfam12080 926562007143 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 926562007144 gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525 926562007145 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 926562007146 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 926562007147 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 926562007148 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 926562007149 putative active site [active] 926562007150 putative metal binding site [ion binding]; other site 926562007151 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 926562007152 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 926562007153 active site 926562007154 interdomain interaction site; other site 926562007155 putative metal-binding site [ion binding]; other site 926562007156 nucleotide binding site [chemical binding]; other site 926562007157 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 926562007158 domain I; other site 926562007159 DNA binding groove [nucleotide binding] 926562007160 phosphate binding site [ion binding]; other site 926562007161 domain II; other site 926562007162 domain III; other site 926562007163 nucleotide binding site [chemical binding]; other site 926562007164 catalytic site [active] 926562007165 domain IV; other site 926562007166 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 926562007167 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 926562007168 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 926562007169 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 926562007170 TRAM domain; Region: TRAM; pfam01938 926562007171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562007172 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 926562007173 Walker A motif; other site 926562007174 ATP binding site [chemical binding]; other site 926562007175 Walker B motif; other site 926562007176 arginine finger; other site 926562007177 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 926562007178 Lipopolysaccharide-assembly; Region: LptE; pfam04390 926562007179 Preprotein translocase SecG subunit; Region: SecG; pfam03840 926562007180 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 926562007181 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 926562007182 oligomerisation interface [polypeptide binding]; other site 926562007183 mobile loop; other site 926562007184 roof hairpin; other site 926562007185 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 926562007186 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 926562007187 ring oligomerisation interface [polypeptide binding]; other site 926562007188 ATP/Mg binding site [chemical binding]; other site 926562007189 stacking interactions; other site 926562007190 hinge regions; other site 926562007191 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 926562007192 putative active site [active] 926562007193 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cl00097 926562007194 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562007195 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562007196 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562007197 binding surface 926562007198 TPR motif; other site 926562007199 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562007200 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 926562007201 binding surface 926562007202 TPR motif; other site 926562007203 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562007204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 926562007205 Histidine kinase; Region: HisKA_3; pfam07730 926562007206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562007207 ATP binding site [chemical binding]; other site 926562007208 Mg2+ binding site [ion binding]; other site 926562007209 G-X-G motif; other site 926562007210 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926562007211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562007212 active site 926562007213 phosphorylation site [posttranslational modification] 926562007214 intermolecular recognition site; other site 926562007215 dimerization interface [polypeptide binding]; other site 926562007216 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926562007217 DNA binding residues [nucleotide binding] 926562007218 dimerization interface [polypeptide binding]; other site 926562007219 Yqey-like protein; Region: YqeY; pfam09424 926562007220 cell division protein FtsZ; Validated; Region: PRK09330 926562007221 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 926562007222 nucleotide binding site [chemical binding]; other site 926562007223 SulA interaction site; other site 926562007224 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 926562007225 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 926562007226 nucleotide binding site [chemical binding]; other site 926562007227 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 926562007228 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 926562007229 Cell division protein FtsA; Region: FtsA; pfam14450 926562007230 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 926562007231 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 926562007232 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 926562007233 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 926562007234 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 926562007235 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 926562007236 active site 926562007237 homodimer interface [polypeptide binding]; other site 926562007238 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 926562007239 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 926562007240 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 926562007241 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 926562007242 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 926562007243 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 926562007244 Mg++ binding site [ion binding]; other site 926562007245 putative catalytic motif [active] 926562007246 putative substrate binding site [chemical binding]; other site 926562007247 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 926562007248 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 926562007249 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 926562007250 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 926562007251 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 926562007252 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 926562007253 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 926562007254 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 926562007255 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 926562007256 MraW methylase family; Region: Methyltransf_5; cl17771 926562007257 cell division protein MraZ; Reviewed; Region: PRK00326 926562007258 MraZ protein; Region: MraZ; pfam02381 926562007259 MraZ protein; Region: MraZ; pfam02381 926562007260 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 926562007261 G1 box; other site 926562007262 GTP/Mg2+ binding site [chemical binding]; other site 926562007263 Switch I region; other site 926562007264 G2 box; other site 926562007265 G3 box; other site 926562007266 Switch II region; other site 926562007267 G4 box; other site 926562007268 G5 box; other site 926562007269 gliding motility-associated protein GldC; Region: GldC; TIGR03515 926562007270 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 926562007271 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926562007272 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 926562007273 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 926562007274 homodimer interface [polypeptide binding]; other site 926562007275 NAD binding pocket [chemical binding]; other site 926562007276 ATP binding pocket [chemical binding]; other site 926562007277 Mg binding site [ion binding]; other site 926562007278 active-site loop [active] 926562007279 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926562007280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562007281 active site 926562007282 phosphorylation site [posttranslational modification] 926562007283 intermolecular recognition site; other site 926562007284 dimerization interface [polypeptide binding]; other site 926562007285 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926562007286 DNA binding residues [nucleotide binding] 926562007287 dimerization interface [polypeptide binding]; other site 926562007288 GTP-binding protein Der; Reviewed; Region: PRK00093 926562007289 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 926562007290 G1 box; other site 926562007291 GTP/Mg2+ binding site [chemical binding]; other site 926562007292 Switch I region; other site 926562007293 G2 box; other site 926562007294 Switch II region; other site 926562007295 G3 box; other site 926562007296 G4 box; other site 926562007297 G5 box; other site 926562007298 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 926562007299 G1 box; other site 926562007300 GTP/Mg2+ binding site [chemical binding]; other site 926562007301 Switch I region; other site 926562007302 G2 box; other site 926562007303 G3 box; other site 926562007304 Switch II region; other site 926562007305 G4 box; other site 926562007306 G5 box; other site 926562007307 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 926562007308 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 926562007309 Walker A/P-loop; other site 926562007310 ATP binding site [chemical binding]; other site 926562007311 Q-loop/lid; other site 926562007312 ABC transporter signature motif; other site 926562007313 Walker B; other site 926562007314 D-loop; other site 926562007315 H-loop/switch region; other site 926562007316 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 926562007317 sulfotransferase; Region: PLN02164 926562007318 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 926562007319 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 926562007320 GTPase RsgA; Reviewed; Region: PRK00098 926562007321 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 926562007322 RNA binding site [nucleotide binding]; other site 926562007323 homodimer interface [polypeptide binding]; other site 926562007324 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 926562007325 GTPase/Zn-binding domain interface [polypeptide binding]; other site 926562007326 GTP/Mg2+ binding site [chemical binding]; other site 926562007327 G4 box; other site 926562007328 G5 box; other site 926562007329 G1 box; other site 926562007330 Switch I region; other site 926562007331 G2 box; other site 926562007332 G3 box; other site 926562007333 Switch II region; other site 926562007334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926562007335 active site 926562007336 motif I; other site 926562007337 motif II; other site 926562007338 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 926562007339 putative active site [active] 926562007340 dimerization interface [polypeptide binding]; other site 926562007341 putative tRNAtyr binding site [nucleotide binding]; other site 926562007342 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 926562007343 homodimer interface [polypeptide binding]; other site 926562007344 metal binding site [ion binding]; metal-binding site 926562007345 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562007346 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926562007347 TonB-dependent Receptor Plug Domain; Region: Plug; cl08461 926562007348 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562007349 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 926562007350 AAA domain; Region: AAA_28; pfam13521 926562007351 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 926562007352 geranylgeranylglyceryl phosphate synthase-like protein; Reviewed; Region: PRK04169 926562007353 PcrB family; Region: PcrB; pfam01884 926562007354 phosphate binding site [ion binding]; other site 926562007355 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 926562007356 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 926562007357 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 926562007358 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 926562007359 homotetramer interface [polypeptide binding]; other site 926562007360 ligand binding site [chemical binding]; other site 926562007361 catalytic site [active] 926562007362 NAD binding site [chemical binding]; other site 926562007363 Response regulator receiver domain; Region: Response_reg; pfam00072 926562007364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562007365 active site 926562007366 phosphorylation site [posttranslational modification] 926562007367 intermolecular recognition site; other site 926562007368 dimerization interface [polypeptide binding]; other site 926562007369 GTPase Era; Reviewed; Region: era; PRK00089 926562007370 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 926562007371 G1 box; other site 926562007372 GTP/Mg2+ binding site [chemical binding]; other site 926562007373 Switch I region; other site 926562007374 G2 box; other site 926562007375 Switch II region; other site 926562007376 G3 box; other site 926562007377 G4 box; other site 926562007378 G5 box; other site 926562007379 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 926562007380 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 926562007381 Leucine-rich repeats; other site 926562007382 Substrate binding site [chemical binding]; other site 926562007383 Leucine rich repeat; Region: LRR_8; pfam13855 926562007384 Leucine rich repeat; Region: LRR_8; pfam13855 926562007385 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 926562007386 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 926562007387 active site 926562007388 Riboflavin kinase; Region: Flavokinase; pfam01687 926562007389 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 926562007390 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 926562007391 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 926562007392 alpha subunit interaction interface [polypeptide binding]; other site 926562007393 Walker A motif; other site 926562007394 ATP binding site [chemical binding]; other site 926562007395 Walker B motif; other site 926562007396 inhibitor binding site; inhibition site 926562007397 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 926562007398 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 926562007399 gamma subunit interface [polypeptide binding]; other site 926562007400 LBP interface [polypeptide binding]; other site 926562007401 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 926562007402 iron-sulfur cluster [ion binding]; other site 926562007403 [2Fe-2S] cluster binding site [ion binding]; other site 926562007404 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 926562007405 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926562007406 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926562007407 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562007408 Uncharacterized protein family (UPF0164); Region: UPF0164; pfam03687 926562007409 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 926562007410 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 926562007411 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 926562007412 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 926562007413 nucleotide binding site/active site [active] 926562007414 HIT family signature motif; other site 926562007415 catalytic residue [active] 926562007416 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 926562007417 active site 926562007418 putative DNA-binding cleft [nucleotide binding]; other site 926562007419 dimer interface [polypeptide binding]; other site 926562007420 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926562007421 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926562007422 active site 926562007423 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 926562007424 Mechanosensitive ion channel; Region: MS_channel; pfam00924 926562007425 C-terminal peptidase (prc); Region: prc; TIGR00225 926562007426 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 926562007427 protein binding site [polypeptide binding]; other site 926562007428 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 926562007429 Catalytic dyad [active] 926562007430 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 926562007431 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 926562007432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926562007433 dimer interface [polypeptide binding]; other site 926562007434 conserved gate region; other site 926562007435 putative PBP binding loops; other site 926562007436 ABC-ATPase subunit interface; other site 926562007437 YceI-like domain; Region: YceI; pfam04264 926562007438 YceI-like domain; Region: YceI; cl01001 926562007439 Domain of unknown function (DU1801); Region: DUF1801; cl17490 926562007440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 926562007441 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 926562007442 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 926562007443 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 926562007444 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 926562007445 Predicted transcriptional regulator [Transcription]; Region: COG2378 926562007446 HTH domain; Region: HTH_11; pfam08279 926562007447 WYL domain; Region: WYL; pfam13280 926562007448 DinB family; Region: DinB; cl17821 926562007449 DinB superfamily; Region: DinB_2; pfam12867 926562007450 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 926562007451 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 926562007452 catalytic residues [active] 926562007453 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562007454 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562007455 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 926562007456 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 926562007457 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 926562007458 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562007459 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 926562007460 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 926562007461 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 926562007462 active site 926562007463 oxyanion hole [active] 926562007464 catalytic triad [active] 926562007465 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 926562007466 starch binding outer membrane protein SusD; Region: SusD; cl17845 926562007467 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 926562007468 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562007469 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 926562007470 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562007471 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 926562007472 Radical SAM superfamily; Region: Radical_SAM; pfam04055 926562007473 FeS/SAM binding site; other site 926562007474 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 926562007475 Phosphotransferase enzyme family; Region: APH; pfam01636 926562007476 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 926562007477 active site 926562007478 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 926562007479 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926562007480 Walker A/P-loop; other site 926562007481 ATP binding site [chemical binding]; other site 926562007482 Q-loop/lid; other site 926562007483 ABC transporter signature motif; other site 926562007484 Walker B; other site 926562007485 D-loop; other site 926562007486 H-loop/switch region; other site 926562007487 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 926562007488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926562007489 putative PBP binding loops; other site 926562007490 dimer interface [polypeptide binding]; other site 926562007491 ABC-ATPase subunit interface; other site 926562007492 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 926562007493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926562007494 dimer interface [polypeptide binding]; other site 926562007495 conserved gate region; other site 926562007496 putative PBP binding loops; other site 926562007497 ABC-ATPase subunit interface; other site 926562007498 hypothetical protein; Provisional; Region: PRK11622 926562007499 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 926562007500 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 926562007501 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 926562007502 active site residue [active] 926562007503 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 926562007504 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 926562007505 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 926562007506 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 926562007507 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 926562007508 Probable Catalytic site; other site 926562007509 Protein of unknown function, DUF547; Region: DUF547; pfam04784 926562007510 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 926562007511 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926562007512 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 926562007513 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 926562007514 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 926562007515 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 926562007516 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 926562007517 Probable Catalytic site; other site 926562007518 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562007519 Right handed beta helix region; Region: Beta_helix; pfam13229 926562007520 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562007521 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 926562007522 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 926562007523 active site 926562007524 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 926562007525 Transposase; Region: DEDD_Tnp_IS110; pfam01548 926562007526 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 926562007527 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 926562007528 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 926562007529 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562007530 Interdomain contacts; other site 926562007531 Cytokine receptor motif; other site 926562007532 Right handed beta helix region; Region: Beta_helix; pfam13229 926562007533 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 926562007534 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562007535 pyruvate carboxylase; Reviewed; Region: PRK12999 926562007536 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 926562007537 ATP-grasp domain; Region: ATP-grasp_4; cl17255 926562007538 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 926562007539 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 926562007540 active site 926562007541 catalytic residues [active] 926562007542 metal binding site [ion binding]; metal-binding site 926562007543 homodimer binding site [polypeptide binding]; other site 926562007544 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 926562007545 carboxyltransferase (CT) interaction site; other site 926562007546 biotinylation site [posttranslational modification]; other site 926562007547 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 926562007548 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 926562007549 active site residue [active] 926562007550 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 926562007551 active site residue [active] 926562007552 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 926562007553 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 926562007554 active site residue [active] 926562007555 TIGR03790 family protein; Region: TIGR03790 926562007556 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562007557 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 926562007558 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 926562007559 N-terminal plug; other site 926562007560 ligand-binding site [chemical binding]; other site 926562007561 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 926562007562 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562007563 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562007564 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 926562007565 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 926562007566 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 926562007567 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 926562007568 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 926562007569 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 926562007570 Protein of unknown function (DUF707); Region: DUF707; pfam05212 926562007571 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 926562007572 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562007573 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 926562007574 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562007575 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 926562007576 metal-binding site [ion binding] 926562007577 Helix-turn-helix domain; Region: HTH_18; pfam12833 926562007578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 926562007579 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 926562007580 Sporulation related domain; Region: SPOR; pfam05036 926562007581 trigger factor; Region: tig; TIGR00115 926562007582 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 926562007583 Clp protease; Region: CLP_protease; pfam00574 926562007584 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 926562007585 oligomer interface [polypeptide binding]; other site 926562007586 active site residues [active] 926562007587 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 926562007588 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 926562007589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562007590 Walker A motif; other site 926562007591 ATP binding site [chemical binding]; other site 926562007592 Walker B motif; other site 926562007593 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 926562007594 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 926562007595 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 926562007596 folate binding site [chemical binding]; other site 926562007597 NADP+ binding site [chemical binding]; other site 926562007598 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 926562007599 thymidylate synthase; Reviewed; Region: thyA; PRK01827 926562007600 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 926562007601 dimerization interface [polypeptide binding]; other site 926562007602 active site 926562007603 Bifunctional nuclease; Region: DNase-RNase; pfam02577 926562007604 UvrB/uvrC motif; Region: UVR; pfam02151 926562007605 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 926562007606 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 926562007607 Ligand Binding Site [chemical binding]; other site 926562007608 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 926562007609 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 926562007610 Ligand binding site [chemical binding]; other site 926562007611 Electron transfer flavoprotein domain; Region: ETF; pfam01012 926562007612 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 926562007613 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 926562007614 alpha subunit interface [polypeptide binding]; other site 926562007615 TPP binding site [chemical binding]; other site 926562007616 heterodimer interface [polypeptide binding]; other site 926562007617 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 926562007618 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 926562007619 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 926562007620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562007621 S-adenosylmethionine binding site [chemical binding]; other site 926562007622 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 926562007623 O-Antigen ligase; Region: Wzy_C; pfam04932 926562007624 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 926562007625 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 926562007626 Substrate-binding site [chemical binding]; other site 926562007627 Substrate specificity [chemical binding]; other site 926562007628 GH3 auxin-responsive promoter; Region: GH3; pfam03321 926562007629 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 926562007630 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 926562007631 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 926562007632 tandem repeat interface [polypeptide binding]; other site 926562007633 oligomer interface [polypeptide binding]; other site 926562007634 active site residues [active] 926562007635 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 926562007636 tandem repeat interface [polypeptide binding]; other site 926562007637 oligomer interface [polypeptide binding]; other site 926562007638 active site residues [active] 926562007639 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 926562007640 catalytic center binding site [active] 926562007641 ATP binding site [chemical binding]; other site 926562007642 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 926562007643 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 926562007644 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 926562007645 ligand binding site [chemical binding]; other site 926562007646 Integrase core domain; Region: rve; pfam00665 926562007647 Integrase core domain; Region: rve_3; pfam13683 926562007648 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 926562007649 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 926562007650 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 926562007651 MutS domain I; Region: MutS_I; pfam01624 926562007652 MutS domain II; Region: MutS_II; pfam05188 926562007653 MutS domain III; Region: MutS_III; pfam05192 926562007654 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 926562007655 Walker A/P-loop; other site 926562007656 ATP binding site [chemical binding]; other site 926562007657 Q-loop/lid; other site 926562007658 ABC transporter signature motif; other site 926562007659 Walker B; other site 926562007660 D-loop; other site 926562007661 H-loop/switch region; other site 926562007662 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 926562007663 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 926562007664 SEC-C motif; Region: SEC-C; pfam02810 926562007665 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562007666 Plastocyanin-like domain; Region: Cu_bind_like; pfam02298 926562007667 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562007668 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 926562007669 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 926562007670 SpoVG; Region: SpoVG; cl00915 926562007671 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562007672 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 926562007673 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 926562007674 homodimer interface [polypeptide binding]; other site 926562007675 oligonucleotide binding site [chemical binding]; other site 926562007676 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562007677 TPR motif; other site 926562007678 TPR repeat; Region: TPR_11; pfam13414 926562007679 binding surface 926562007680 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 926562007681 IHF dimer interface [polypeptide binding]; other site 926562007682 IHF - DNA interface [nucleotide binding]; other site 926562007683 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 926562007684 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 926562007685 minor groove reading motif; other site 926562007686 helix-hairpin-helix signature motif; other site 926562007687 substrate binding pocket [chemical binding]; other site 926562007688 active site 926562007689 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 926562007690 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 926562007691 DNA binding and oxoG recognition site [nucleotide binding] 926562007692 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 926562007693 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 926562007694 dimer interface [polypeptide binding]; other site 926562007695 ssDNA binding site [nucleotide binding]; other site 926562007696 tetramer (dimer of dimers) interface [polypeptide binding]; other site 926562007697 gliding motility-associated protein GldE; Region: GldE; TIGR03520 926562007698 Domain of unknown function DUF21; Region: DUF21; pfam01595 926562007699 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 926562007700 Transporter associated domain; Region: CorC_HlyC; smart01091 926562007701 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 926562007702 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 926562007703 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 926562007704 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 926562007705 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 926562007706 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 926562007707 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 926562007708 putative active site [active] 926562007709 Zn binding site [ion binding]; other site 926562007710 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 926562007711 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 926562007712 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 926562007713 putative tRNA-binding site [nucleotide binding]; other site 926562007714 B3/4 domain; Region: B3_4; pfam03483 926562007715 tRNA synthetase B5 domain; Region: B5; smart00874 926562007716 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 926562007717 dimer interface [polypeptide binding]; other site 926562007718 motif 1; other site 926562007719 motif 3; other site 926562007720 motif 2; other site 926562007721 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 926562007722 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 926562007723 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 926562007724 POT family; Region: PTR2; cl17359 926562007725 POT family; Region: PTR2; cl17359 926562007726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 926562007727 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 926562007728 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926562007729 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 926562007730 FAD binding domain; Region: FAD_binding_4; pfam01565 926562007731 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 926562007732 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562007733 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562007734 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 926562007735 FOG: PKD repeat [General function prediction only]; Region: COG3291 926562007736 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562007737 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 926562007738 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 926562007739 inhibitor-cofactor binding pocket; inhibition site 926562007740 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562007741 catalytic residue [active] 926562007742 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 926562007743 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 926562007744 O-Antigen ligase; Region: Wzy_C; pfam04932 926562007745 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562007746 TPR motif; other site 926562007747 binding surface 926562007748 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 926562007749 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 926562007750 active site 926562007751 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 926562007752 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 926562007753 active site 926562007754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 926562007755 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 926562007756 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 926562007757 Walker A/P-loop; other site 926562007758 ATP binding site [chemical binding]; other site 926562007759 Q-loop/lid; other site 926562007760 ABC transporter signature motif; other site 926562007761 Walker B; other site 926562007762 D-loop; other site 926562007763 H-loop/switch region; other site 926562007764 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 926562007765 putative carbohydrate binding site [chemical binding]; other site 926562007766 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 926562007767 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 926562007768 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 926562007769 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 926562007770 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 926562007771 generic binding surface II; other site 926562007772 ssDNA binding site; other site 926562007773 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926562007774 ATP binding site [chemical binding]; other site 926562007775 putative Mg++ binding site [ion binding]; other site 926562007776 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926562007777 nucleotide binding region [chemical binding]; other site 926562007778 ATP-binding site [chemical binding]; other site 926562007779 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 926562007780 Zn binding site [ion binding]; other site 926562007781 HEAT repeats; Region: HEAT_2; pfam13646 926562007782 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 926562007783 Bacterial sugar transferase; Region: Bac_transf; pfam02397 926562007784 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926562007785 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 926562007786 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926562007787 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 926562007788 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 926562007789 BioY family; Region: BioY; pfam02632 926562007790 multidrug efflux protein; Reviewed; Region: PRK01766 926562007791 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 926562007792 cation binding site [ion binding]; other site 926562007793 Response regulator receiver domain; Region: Response_reg; pfam00072 926562007794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562007795 active site 926562007796 phosphorylation site [posttranslational modification] 926562007797 intermolecular recognition site; other site 926562007798 dimerization interface [polypeptide binding]; other site 926562007799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562007800 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 926562007801 Walker A motif; other site 926562007802 ATP binding site [chemical binding]; other site 926562007803 Walker B motif; other site 926562007804 arginine finger; other site 926562007805 exopolyphosphatase; Region: exo_poly_only; TIGR03706 926562007806 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 926562007807 Mechanosensitive ion channel; Region: MS_channel; pfam00924 926562007808 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 926562007809 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 926562007810 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 926562007811 Walker A/P-loop; other site 926562007812 ATP binding site [chemical binding]; other site 926562007813 Q-loop/lid; other site 926562007814 ABC transporter signature motif; other site 926562007815 Walker B; other site 926562007816 D-loop; other site 926562007817 H-loop/switch region; other site 926562007818 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 926562007819 chaperone protein DnaJ; Provisional; Region: PRK14289 926562007820 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 926562007821 HSP70 interaction site [polypeptide binding]; other site 926562007822 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 926562007823 substrate binding site [polypeptide binding]; other site 926562007824 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 926562007825 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 926562007826 dimer interface [polypeptide binding]; other site 926562007827 GrpE; Region: GrpE; pfam01025 926562007828 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 926562007829 dimer interface [polypeptide binding]; other site 926562007830 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 926562007831 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926562007832 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926562007833 catalytic residues [active] 926562007834 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 926562007835 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 926562007836 hinge; other site 926562007837 active site 926562007838 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 926562007839 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 926562007840 Part of AAA domain; Region: AAA_19; pfam13245 926562007841 Elongation factor TS; Region: EF_TS; pfam00889 926562007842 Family description; Region: UvrD_C_2; pfam13538 926562007843 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 926562007844 S17 interaction site [polypeptide binding]; other site 926562007845 S8 interaction site; other site 926562007846 16S rRNA interaction site [nucleotide binding]; other site 926562007847 streptomycin interaction site [chemical binding]; other site 926562007848 23S rRNA interaction site [nucleotide binding]; other site 926562007849 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 926562007850 30S ribosomal protein S7; Validated; Region: PRK05302 926562007851 elongation factor G; Reviewed; Region: PRK12739 926562007852 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 926562007853 G1 box; other site 926562007854 putative GEF interaction site [polypeptide binding]; other site 926562007855 GTP/Mg2+ binding site [chemical binding]; other site 926562007856 Switch I region; other site 926562007857 G2 box; other site 926562007858 G3 box; other site 926562007859 Switch II region; other site 926562007860 G4 box; other site 926562007861 G5 box; other site 926562007862 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 926562007863 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 926562007864 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 926562007865 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 926562007866 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 926562007867 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 926562007868 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 926562007869 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 926562007870 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 926562007871 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 926562007872 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 926562007873 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 926562007874 putative translocon binding site; other site 926562007875 protein-rRNA interface [nucleotide binding]; other site 926562007876 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 926562007877 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 926562007878 G-X-X-G motif; other site 926562007879 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 926562007880 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 926562007881 23S rRNA interface [nucleotide binding]; other site 926562007882 5S rRNA interface [nucleotide binding]; other site 926562007883 putative antibiotic binding site [chemical binding]; other site 926562007884 L25 interface [polypeptide binding]; other site 926562007885 L27 interface [polypeptide binding]; other site 926562007886 50S ribosomal protein L29; Reviewed; Region: PRK00306 926562007887 L23 interface [polypeptide binding]; other site 926562007888 trigger factor interaction site; other site 926562007889 23S rRNA interface [nucleotide binding]; other site 926562007890 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 926562007891 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 926562007892 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 926562007893 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 926562007894 RNA binding site [nucleotide binding]; other site 926562007895 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 926562007896 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 926562007897 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 926562007898 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 926562007899 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 926562007900 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 926562007901 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 926562007902 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 926562007903 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 926562007904 5S rRNA interface [nucleotide binding]; other site 926562007905 L27 interface [polypeptide binding]; other site 926562007906 23S rRNA interface [nucleotide binding]; other site 926562007907 L5 interface [polypeptide binding]; other site 926562007908 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 926562007909 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 926562007910 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 926562007911 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 926562007912 23S rRNA binding site [nucleotide binding]; other site 926562007913 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 926562007914 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 926562007915 SecY translocase; Region: SecY; pfam00344 926562007916 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 926562007917 rRNA binding site [nucleotide binding]; other site 926562007918 predicted 30S ribosome binding site; other site 926562007919 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 926562007920 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 926562007921 30S ribosomal protein S13; Region: bact_S13; TIGR03631 926562007922 30S ribosomal protein S11; Validated; Region: PRK05309 926562007923 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 926562007924 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 926562007925 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 926562007926 RNA binding surface [nucleotide binding]; other site 926562007927 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 926562007928 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 926562007929 alphaNTD homodimer interface [polypeptide binding]; other site 926562007930 alphaNTD - beta interaction site [polypeptide binding]; other site 926562007931 alphaNTD - beta' interaction site [polypeptide binding]; other site 926562007932 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 926562007933 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 926562007934 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 926562007935 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 926562007936 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 926562007937 catalytic site [active] 926562007938 subunit interface [polypeptide binding]; other site 926562007939 enolase; Provisional; Region: eno; PRK00077 926562007940 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 926562007941 dimer interface [polypeptide binding]; other site 926562007942 metal binding site [ion binding]; metal-binding site 926562007943 substrate binding pocket [chemical binding]; other site 926562007944 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 926562007945 citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793 926562007946 oxalacetate binding site [chemical binding]; other site 926562007947 citrylCoA binding site [chemical binding]; other site 926562007948 coenzyme A binding site [chemical binding]; other site 926562007949 catalytic triad [active] 926562007950 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 926562007951 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 926562007952 RNA binding site [nucleotide binding]; other site 926562007953 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 926562007954 RNA binding site [nucleotide binding]; other site 926562007955 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 926562007956 RNA binding site [nucleotide binding]; other site 926562007957 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 926562007958 RNA binding site [nucleotide binding]; other site 926562007959 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 926562007960 RNA binding site [nucleotide binding]; other site 926562007961 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 926562007962 RNA binding site [nucleotide binding]; other site 926562007963 Uncharacterized conserved protein [Function unknown]; Region: COG0327 926562007964 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 926562007965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 926562007966 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 926562007967 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 926562007968 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 926562007969 Putative zinc ribbon domain; Region: DUF164; pfam02591 926562007970 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 926562007971 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 926562007972 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 926562007973 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 926562007974 NlpC/P60 family; Region: NLPC_P60; pfam00877 926562007975 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 926562007976 Zn binding site [ion binding]; other site 926562007977 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 926562007978 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 926562007979 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 926562007980 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 926562007981 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 926562007982 substrate binding site [chemical binding]; other site 926562007983 active site 926562007984 catalytic residues [active] 926562007985 heterodimer interface [polypeptide binding]; other site 926562007986 bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional; Region: PRK13803 926562007987 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 926562007988 active site 926562007989 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 926562007990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562007991 catalytic residue [active] 926562007992 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 926562007993 active site 926562007994 ribulose/triose binding site [chemical binding]; other site 926562007995 phosphate binding site [ion binding]; other site 926562007996 substrate (anthranilate) binding pocket [chemical binding]; other site 926562007997 product (indole) binding pocket [chemical binding]; other site 926562007998 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 926562007999 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 926562008000 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 926562008001 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 926562008002 Glutamine amidotransferase class-I; Region: GATase; pfam00117 926562008003 glutamine binding [chemical binding]; other site 926562008004 catalytic triad [active] 926562008005 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 926562008006 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 926562008007 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 926562008008 BNR repeat-like domain; Region: BNR_2; pfam13088 926562008009 BNR repeat-like domain; Region: BNR_2; pfam13088 926562008010 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 926562008011 four helix bundle protein; Region: TIGR02436 926562008012 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 926562008013 active site pocket [active] 926562008014 oxyanion hole [active] 926562008015 catalytic triad [active] 926562008016 active site nucleophile [active] 926562008017 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 926562008018 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 926562008019 A new structural DNA glycosylase; Region: AlkD_like; cd06561 926562008020 active site 926562008021 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008022 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 926562008023 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 926562008024 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 926562008025 active site 926562008026 Zn binding site [ion binding]; other site 926562008027 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008028 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 926562008029 phosphoglyceromutase; Provisional; Region: PRK05434 926562008030 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 926562008031 active site 926562008032 motif I; other site 926562008033 motif II; other site 926562008034 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 926562008035 active site 926562008036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562008037 Methyltransferase domain; Region: Methyltransf_31; pfam13847 926562008038 PIN domain; Region: PIN_3; pfam13470 926562008039 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926562008040 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 926562008041 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 926562008042 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 926562008043 active site 926562008044 HIGH motif; other site 926562008045 nucleotide binding site [chemical binding]; other site 926562008046 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 926562008047 KMSKS motif; other site 926562008048 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 926562008049 tRNA binding surface [nucleotide binding]; other site 926562008050 anticodon binding site; other site 926562008051 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 926562008052 GTP cyclohydrolase I; Provisional; Region: PLN03044 926562008053 active site 926562008054 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008055 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 926562008056 prolyl-tRNA synthetase; Provisional; Region: PRK08661 926562008057 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 926562008058 dimer interface [polypeptide binding]; other site 926562008059 motif 1; other site 926562008060 active site 926562008061 motif 2; other site 926562008062 motif 3; other site 926562008063 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 926562008064 anticodon binding site; other site 926562008065 zinc-binding site [ion binding]; other site 926562008066 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 926562008067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926562008068 TIGR01777 family protein; Region: yfcH 926562008069 NAD(P) binding site [chemical binding]; other site 926562008070 active site 926562008071 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 926562008072 nudix motif; other site 926562008073 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 926562008074 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 926562008075 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 926562008076 homodimer interface [polypeptide binding]; other site 926562008077 substrate-cofactor binding pocket; other site 926562008078 catalytic residue [active] 926562008079 PKD domain; Region: PKD; pfam00801 926562008080 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 926562008081 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562008082 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008083 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 926562008084 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 926562008085 FOG: PKD repeat [General function prediction only]; Region: COG3291 926562008086 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562008087 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562008088 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008089 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 926562008090 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 926562008091 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562008092 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562008093 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008094 S-adenosylmethionine synthetase; Validated; Region: PRK05250 926562008095 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 926562008096 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 926562008097 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 926562008098 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 926562008099 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 926562008100 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 926562008101 NAD(P) binding site [chemical binding]; other site 926562008102 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 926562008103 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 926562008104 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 926562008105 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 926562008106 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 926562008107 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 926562008108 four helix bundle protein; Region: TIGR02436 926562008109 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 926562008110 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 926562008111 substrate binding pocket [chemical binding]; other site 926562008112 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 926562008113 B12 binding site [chemical binding]; other site 926562008114 cobalt ligand [ion binding]; other site 926562008115 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 926562008116 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 926562008117 FAD binding site [chemical binding]; other site 926562008118 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 926562008119 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 926562008120 putative active site [active] 926562008121 PhoH-like protein; Region: PhoH; pfam02562 926562008122 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 926562008123 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 926562008124 catalytic site [active] 926562008125 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 926562008126 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 926562008127 active site 926562008128 substrate-binding site [chemical binding]; other site 926562008129 metal-binding site [ion binding] 926562008130 ATP binding site [chemical binding]; other site 926562008131 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 926562008132 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 926562008133 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 926562008134 NAD(P) binding pocket [chemical binding]; other site 926562008135 Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately...; Region: REM; cl02520 926562008136 GTPase interaction site [polypeptide binding]; other site 926562008137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926562008138 active site 926562008139 motif I; other site 926562008140 motif II; other site 926562008141 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 926562008142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562008143 S-adenosylmethionine binding site [chemical binding]; other site 926562008144 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 926562008145 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 926562008146 RimM N-terminal domain; Region: RimM; pfam01782 926562008147 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 926562008148 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 926562008149 TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779 926562008150 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562008151 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008152 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008153 hypothetical protein; Provisional; Region: PRK10279 926562008154 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 926562008155 active site 926562008156 nucleophile elbow; other site 926562008157 Predicted transcriptional regulator [Transcription]; Region: COG3655 926562008158 salt bridge; other site 926562008159 non-specific DNA binding site [nucleotide binding]; other site 926562008160 sequence-specific DNA binding site [nucleotide binding]; other site 926562008161 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 926562008162 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 926562008163 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 926562008164 active site 926562008165 catalytic site [active] 926562008166 substrate binding site [chemical binding]; other site 926562008167 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 926562008168 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 926562008169 active site 926562008170 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 926562008171 generic binding surface II; other site 926562008172 generic binding surface I; other site 926562008173 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 926562008174 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926562008175 catalytic residues [active] 926562008176 Protein of unknown function DUF58; Region: DUF58; pfam01882 926562008177 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926562008178 active site 926562008179 DNA binding site [nucleotide binding] 926562008180 Int/Topo IB signature motif; other site 926562008181 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 926562008182 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 926562008183 PAS fold; Region: PAS_4; pfam08448 926562008184 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 926562008185 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 926562008186 tandem repeat interface [polypeptide binding]; other site 926562008187 oligomer interface [polypeptide binding]; other site 926562008188 active site residues [active] 926562008189 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 926562008190 catalytic residue [active] 926562008191 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 926562008192 Influenza C hemagglutinin stalk; Region: Hema_stalk; pfam08720 926562008193 Uncharacterized protein conserved in archaea (DUF2096); Region: DUF2096; cl01637 926562008194 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 926562008195 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 926562008196 cofactor binding site; other site 926562008197 DNA binding site [nucleotide binding] 926562008198 substrate interaction site [chemical binding]; other site 926562008199 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 926562008200 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926562008201 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926562008202 DNA binding residues [nucleotide binding] 926562008203 dimerization interface [polypeptide binding]; other site 926562008204 Helix-turn-helix domain; Region: HTH_17; pfam12728 926562008205 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409 926562008206 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409 926562008207 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 926562008208 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926562008209 active site 926562008210 DNA binding site [nucleotide binding] 926562008211 Int/Topo IB signature motif; other site 926562008212 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562008213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 926562008214 binding surface 926562008215 TPR motif; other site 926562008216 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562008217 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 926562008218 Histidine kinase; Region: HisKA_3; pfam07730 926562008219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562008220 ATP binding site [chemical binding]; other site 926562008221 Mg2+ binding site [ion binding]; other site 926562008222 G-X-G motif; other site 926562008223 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926562008224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562008225 active site 926562008226 phosphorylation site [posttranslational modification] 926562008227 intermolecular recognition site; other site 926562008228 dimerization interface [polypeptide binding]; other site 926562008229 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926562008230 DNA binding residues [nucleotide binding] 926562008231 dimerization interface [polypeptide binding]; other site 926562008232 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 926562008233 hydrophobic ligand binding site; other site 926562008234 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562008235 FOG: PKD repeat [General function prediction only]; Region: COG3291 926562008236 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562008237 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562008238 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562008239 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008240 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562008241 FOG: PKD repeat [General function prediction only]; Region: COG3291 926562008242 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562008243 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008244 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008245 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 926562008246 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 926562008247 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 926562008248 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 926562008249 nucleotide binding region [chemical binding]; other site 926562008250 ATP-binding site [chemical binding]; other site 926562008251 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 926562008252 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 926562008253 Divergent AAA domain; Region: AAA_4; pfam04326 926562008254 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 926562008255 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 926562008256 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 926562008257 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 926562008258 Methyltransferase domain; Region: Methyltransf_26; pfam13659 926562008259 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 926562008260 active site 926562008261 catalytic triad [active] 926562008262 oxyanion hole [active] 926562008263 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 926562008264 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 926562008265 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 926562008266 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926562008267 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008268 Trm112p-like protein; Region: Trm112p; cl01066 926562008269 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 926562008270 thiamine phosphate binding site [chemical binding]; other site 926562008271 active site 926562008272 pyrophosphate binding site [ion binding]; other site 926562008273 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 926562008274 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 926562008275 dimerization interface [polypeptide binding]; other site 926562008276 putative ATP binding site [chemical binding]; other site 926562008277 Methyltransferase domain; Region: Methyltransf_23; pfam13489 926562008278 Methyltransferase domain; Region: Methyltransf_11; pfam08241 926562008279 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 926562008280 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 926562008281 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 926562008282 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562008283 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562008284 dimer interface [polypeptide binding]; other site 926562008285 phosphorylation site [posttranslational modification] 926562008286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562008287 ATP binding site [chemical binding]; other site 926562008288 Mg2+ binding site [ion binding]; other site 926562008289 G-X-G motif; other site 926562008290 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 926562008291 FOG: PKD repeat [General function prediction only]; Region: COG3291 926562008292 FOG: PKD repeat [General function prediction only]; Region: COG3291 926562008293 FOG: PKD repeat [General function prediction only]; Region: COG3291 926562008294 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 926562008295 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562008296 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562008297 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562008298 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562008299 FOG: PKD repeat [General function prediction only]; Region: COG3291 926562008300 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562008301 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 926562008302 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 926562008303 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 926562008304 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 926562008305 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 926562008306 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 926562008307 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 926562008308 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 926562008309 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 926562008310 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 926562008311 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 926562008312 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 926562008313 C-terminal domain of CHU protein family; Region: CHU_C; cl17875 926562008314 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562008315 putative trimer interface [polypeptide binding]; other site 926562008316 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 926562008317 putative CoA binding site [chemical binding]; other site 926562008318 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 926562008319 putative trimer interface [polypeptide binding]; other site 926562008320 putative active site [active] 926562008321 putative substrate binding site [chemical binding]; other site 926562008322 putative CoA binding site [chemical binding]; other site 926562008323 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 926562008324 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 926562008325 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 926562008326 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 926562008327 TrkA-C domain; Region: TrkA_C; pfam02080 926562008328 TrkA-C domain; Region: TrkA_C; pfam02080 926562008329 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 926562008330 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 926562008331 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 926562008332 ligand-binding site [chemical binding]; other site 926562008333 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 926562008334 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 926562008335 Active Sites [active] 926562008336 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 926562008337 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 926562008338 CysD dimerization site [polypeptide binding]; other site 926562008339 G1 box; other site 926562008340 putative GEF interaction site [polypeptide binding]; other site 926562008341 GTP/Mg2+ binding site [chemical binding]; other site 926562008342 Switch I region; other site 926562008343 G2 box; other site 926562008344 G3 box; other site 926562008345 Switch II region; other site 926562008346 G4 box; other site 926562008347 G5 box; other site 926562008348 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 926562008349 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 926562008350 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 926562008351 active site 926562008352 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 926562008353 homodimer interface [polypeptide binding]; other site 926562008354 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 926562008355 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 926562008356 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 926562008357 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 926562008358 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 926562008359 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 926562008360 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 926562008361 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 926562008362 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 926562008363 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 926562008364 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 926562008365 NAD binding site [chemical binding]; other site 926562008366 substrate binding site [chemical binding]; other site 926562008367 homodimer interface [polypeptide binding]; other site 926562008368 active site 926562008369 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 926562008370 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 926562008371 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 926562008372 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 926562008373 inhibitor-cofactor binding pocket; inhibition site 926562008374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562008375 catalytic residue [active] 926562008376 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 926562008377 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 926562008378 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 926562008379 active site 926562008380 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 926562008381 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 926562008382 active site 926562008383 dimer interface [polypeptide binding]; other site 926562008384 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 926562008385 Ligand Binding Site [chemical binding]; other site 926562008386 Molecular Tunnel; other site 926562008387 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 926562008388 trimer interface [polypeptide binding]; other site 926562008389 active site 926562008390 substrate binding site [chemical binding]; other site 926562008391 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 926562008392 CoA binding site [chemical binding]; other site 926562008393 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 926562008394 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926562008395 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926562008396 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 926562008397 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 926562008398 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 926562008399 active site 926562008400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 926562008401 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 926562008402 NAD(P) binding site [chemical binding]; other site 926562008403 active site 926562008404 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 926562008405 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 926562008406 Mg++ binding site [ion binding]; other site 926562008407 putative catalytic motif [active] 926562008408 putative substrate binding site [chemical binding]; other site 926562008409 Bacterial sugar transferase; Region: Bac_transf; pfam02397 926562008410 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 926562008411 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 926562008412 putative trimer interface [polypeptide binding]; other site 926562008413 putative CoA binding site [chemical binding]; other site 926562008414 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 926562008415 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 926562008416 inhibitor-cofactor binding pocket; inhibition site 926562008417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562008418 catalytic residue [active] 926562008419 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 926562008420 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 926562008421 NAD(P) binding site [chemical binding]; other site 926562008422 homodimer interface [polypeptide binding]; other site 926562008423 substrate binding site [chemical binding]; other site 926562008424 active site 926562008425 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 926562008426 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 926562008427 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 926562008428 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926562008429 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926562008430 Walker A/P-loop; other site 926562008431 ATP binding site [chemical binding]; other site 926562008432 Q-loop/lid; other site 926562008433 ABC transporter signature motif; other site 926562008434 Walker B; other site 926562008435 D-loop; other site 926562008436 H-loop/switch region; other site 926562008437 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926562008438 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 926562008439 FtsX-like permease family; Region: FtsX; pfam02687 926562008440 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926562008441 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 926562008442 FtsX-like permease family; Region: FtsX; pfam02687 926562008443 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 926562008444 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 926562008445 HlyD family secretion protein; Region: HlyD_3; pfam13437 926562008446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 926562008447 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 926562008448 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 926562008449 YceI-like domain; Region: YceI; pfam04264 926562008450 hypothetical protein; Reviewed; Region: PRK00024 926562008451 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 926562008452 MPN+ (JAMM) motif; other site 926562008453 Zinc-binding site [ion binding]; other site 926562008454 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 926562008455 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 926562008456 putative active site [active] 926562008457 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 926562008458 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926562008459 motif II; other site 926562008460 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 926562008461 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 926562008462 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 926562008463 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 926562008464 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 926562008465 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 926562008466 Competence protein; Region: Competence; pfam03772 926562008467 Uncharacterized conserved protein [Function unknown]; Region: COG1624 926562008468 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 926562008469 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 926562008470 dihydropteroate synthase; Region: DHPS; TIGR01496 926562008471 substrate binding pocket [chemical binding]; other site 926562008472 dimer interface [polypeptide binding]; other site 926562008473 inhibitor binding site; inhibition site 926562008474 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 926562008475 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 926562008476 Predicted membrane protein [Function unknown]; Region: COG2259 926562008477 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 926562008478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 926562008479 dimer interface [polypeptide binding]; other site 926562008480 conserved gate region; other site 926562008481 putative PBP binding loops; other site 926562008482 ABC-ATPase subunit interface; other site 926562008483 triosephosphate isomerase; Provisional; Region: PRK14567 926562008484 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 926562008485 substrate binding site [chemical binding]; other site 926562008486 dimer interface [polypeptide binding]; other site 926562008487 catalytic triad [active] 926562008488 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 926562008489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 926562008490 S-adenosylmethionine binding site [chemical binding]; other site 926562008491 Cupin-like domain; Region: Cupin_8; pfam13621 926562008492 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 926562008493 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 926562008494 active site residue [active] 926562008495 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 926562008496 active site residue [active] 926562008497 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 926562008498 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926562008499 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 926562008500 ligand binding site [chemical binding]; other site 926562008501 flexible hinge region; other site 926562008502 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 926562008503 non-specific DNA interactions [nucleotide binding]; other site 926562008504 DNA binding site [nucleotide binding] 926562008505 sequence specific DNA binding site [nucleotide binding]; other site 926562008506 putative cAMP binding site [chemical binding]; other site 926562008507 NMT1/THI5 like; Region: NMT1; pfam09084 926562008508 YceI-like domain; Region: YceI; pfam04264 926562008509 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008510 GTP-binding protein YchF; Reviewed; Region: PRK09601 926562008511 YchF GTPase; Region: YchF; cd01900 926562008512 G1 box; other site 926562008513 GTP/Mg2+ binding site [chemical binding]; other site 926562008514 Switch I region; other site 926562008515 G2 box; other site 926562008516 Switch II region; other site 926562008517 G3 box; other site 926562008518 G4 box; other site 926562008519 G5 box; other site 926562008520 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 926562008521 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 926562008522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562008523 ATP binding site [chemical binding]; other site 926562008524 Mg2+ binding site [ion binding]; other site 926562008525 G-X-G motif; other site 926562008526 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 926562008527 ATP binding site [chemical binding]; other site 926562008528 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 926562008529 active site 926562008530 putative metal-binding site [ion binding]; other site 926562008531 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 926562008532 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 926562008533 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 926562008534 CAP-like domain; other site 926562008535 active site 926562008536 primary dimer interface [polypeptide binding]; other site 926562008537 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 926562008538 Cna protein B-type domain; Region: Cna_B_2; pfam13715 926562008539 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008540 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926562008541 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 926562008542 DXD motif; other site 926562008543 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926562008544 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 926562008545 Probable Catalytic site; other site 926562008546 metal-binding site 926562008547 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 926562008548 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 926562008549 active site 926562008550 dimer interface [polypeptide binding]; other site 926562008551 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 926562008552 Ligand Binding Site [chemical binding]; other site 926562008553 Molecular Tunnel; other site 926562008554 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 926562008555 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 926562008556 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926562008557 putative homodimer interface [polypeptide binding]; other site 926562008558 Core-2/I-Branching enzyme; Region: Branch; pfam02485 926562008559 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 926562008560 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 926562008561 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 926562008562 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 926562008563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562008564 active site 926562008565 phosphorylation site [posttranslational modification] 926562008566 intermolecular recognition site; other site 926562008567 dimerization interface [polypeptide binding]; other site 926562008568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562008569 Walker A motif; other site 926562008570 ATP binding site [chemical binding]; other site 926562008571 Walker B motif; other site 926562008572 arginine finger; other site 926562008573 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 926562008574 Response regulator receiver domain; Region: Response_reg; pfam00072 926562008575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562008576 active site 926562008577 phosphorylation site [posttranslational modification] 926562008578 intermolecular recognition site; other site 926562008579 dimerization interface [polypeptide binding]; other site 926562008580 Bacterial sugar transferase; Region: Bac_transf; cl00939 926562008581 Bacterial sugar transferase; Region: Bac_transf; pfam02397 926562008582 Outer membrane efflux protein; Region: OEP; pfam02321 926562008583 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 926562008584 Chain length determinant protein; Region: Wzz; cl15801 926562008585 AAA domain; Region: AAA_31; pfam13614 926562008586 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 926562008587 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 926562008588 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926562008589 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 926562008590 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 926562008591 DXD motif; other site 926562008592 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 926562008593 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 926562008594 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 926562008595 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 926562008596 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 926562008597 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 926562008598 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 926562008599 N-acetyl-D-glucosamine binding site [chemical binding]; other site 926562008600 catalytic residue [active] 926562008601 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 926562008602 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 926562008603 Alkaline phosphatase homologues; Region: alkPPc; smart00098 926562008604 active site 926562008605 dimer interface [polypeptide binding]; other site 926562008606 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 926562008607 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 926562008608 ATP binding site [chemical binding]; other site 926562008609 putative Mg++ binding site [ion binding]; other site 926562008610 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 926562008611 nucleotide binding region [chemical binding]; other site 926562008612 ATP-binding site [chemical binding]; other site 926562008613 RQC domain; Region: RQC; pfam09382 926562008614 HRDC domain; Region: HRDC; pfam00570 926562008615 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 926562008616 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 926562008617 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 926562008618 Walker A/P-loop; other site 926562008619 ATP binding site [chemical binding]; other site 926562008620 Q-loop/lid; other site 926562008621 ABC transporter signature motif; other site 926562008622 Walker B; other site 926562008623 D-loop; other site 926562008624 H-loop/switch region; other site 926562008625 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 926562008626 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 926562008627 Double zinc ribbon; Region: DZR; pfam12773 926562008628 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 926562008629 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 926562008630 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 926562008631 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 926562008632 FMN-binding domain; Region: FMN_bind; cl01081 926562008633 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 926562008634 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 926562008635 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 926562008636 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 926562008637 catalytic loop [active] 926562008638 iron binding site [ion binding]; other site 926562008639 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 926562008640 FAD binding pocket [chemical binding]; other site 926562008641 FAD binding motif [chemical binding]; other site 926562008642 phosphate binding motif [ion binding]; other site 926562008643 beta-alpha-beta structure motif; other site 926562008644 NAD binding pocket [chemical binding]; other site 926562008645 Response regulator receiver domain; Region: Response_reg; pfam00072 926562008646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562008647 active site 926562008648 phosphorylation site [posttranslational modification] 926562008649 intermolecular recognition site; other site 926562008650 dimerization interface [polypeptide binding]; other site 926562008651 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562008652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562008653 dimer interface [polypeptide binding]; other site 926562008654 phosphorylation site [posttranslational modification] 926562008655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562008656 ATP binding site [chemical binding]; other site 926562008657 Mg2+ binding site [ion binding]; other site 926562008658 G-X-G motif; other site 926562008659 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 926562008660 Methyltransferase domain; Region: Methyltransf_26; pfam13659 926562008661 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 926562008662 Abortive infection C-terminus; Region: Abi_C; pfam14355 926562008663 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 926562008664 HEPN domain; Region: HEPN; cl00824 926562008665 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 926562008666 putative catalytic site [active] 926562008667 putative metal binding site [ion binding]; other site 926562008668 putative phosphate binding site [ion binding]; other site 926562008669 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 926562008670 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562008671 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562008672 Interdomain contacts; other site 926562008673 Cytokine receptor motif; other site 926562008674 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562008675 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562008676 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008677 Smr domain; Region: Smr; pfam01713 926562008678 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 926562008679 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 926562008680 active site residue [active] 926562008681 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 926562008682 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 926562008683 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 926562008684 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 926562008685 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 926562008686 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 926562008687 ligand binding site [chemical binding]; other site 926562008688 homodimer interface [polypeptide binding]; other site 926562008689 NAD(P) binding site [chemical binding]; other site 926562008690 trimer interface B [polypeptide binding]; other site 926562008691 trimer interface A [polypeptide binding]; other site 926562008692 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 926562008693 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 926562008694 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 926562008695 NAD(P) binding site [chemical binding]; other site 926562008696 potassium/proton antiporter; Reviewed; Region: PRK05326 926562008697 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 926562008698 TrkA-C domain; Region: TrkA_C; pfam02080 926562008699 Domain of unknown function DUF302; Region: DUF302; cl01364 926562008700 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 926562008701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562008702 active site 926562008703 phosphorylation site [posttranslational modification] 926562008704 intermolecular recognition site; other site 926562008705 dimerization interface [polypeptide binding]; other site 926562008706 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 926562008707 Walker A motif; other site 926562008708 ATP binding site [chemical binding]; other site 926562008709 Walker B motif; other site 926562008710 arginine finger; other site 926562008711 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 926562008712 GAF domain; Region: GAF; cl17456 926562008713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562008714 dimer interface [polypeptide binding]; other site 926562008715 phosphorylation site [posttranslational modification] 926562008716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562008717 ATP binding site [chemical binding]; other site 926562008718 Mg2+ binding site [ion binding]; other site 926562008719 G-X-G motif; other site 926562008720 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 926562008721 active site 926562008722 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 926562008723 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 926562008724 quinolinate synthetase; Provisional; Region: PRK09375 926562008725 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 926562008726 L-aspartate oxidase; Provisional; Region: PRK06175 926562008727 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 926562008728 Cupin domain; Region: Cupin_2; cl17218 926562008729 Predicted acetyltransferase [General function prediction only]; Region: COG2388 926562008730 Uncharacterized conserved protein [Function unknown]; Region: COG3189 926562008731 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 926562008732 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 926562008733 Walker A/P-loop; other site 926562008734 ATP binding site [chemical binding]; other site 926562008735 Q-loop/lid; other site 926562008736 ABC transporter signature motif; other site 926562008737 Walker B; other site 926562008738 D-loop; other site 926562008739 H-loop/switch region; other site 926562008740 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 926562008741 NosL; Region: NosL; cl01769 926562008742 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 926562008743 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 926562008744 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 926562008745 Cytochrome c; Region: Cytochrom_C; pfam00034 926562008746 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 926562008747 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 926562008748 YtkA-like; Region: YtkA; pfam13115 926562008749 Rrf2 family protein; Region: rrf2_super; TIGR00738 926562008750 Transcriptional regulator; Region: Rrf2; pfam02082 926562008751 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 926562008752 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 926562008753 Hemerythrin-like domain; Region: Hr-like; cd12108 926562008754 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 926562008755 apolar tunnel; other site 926562008756 heme binding site [chemical binding]; other site 926562008757 dimerization interface [polypeptide binding]; other site 926562008758 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 926562008759 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 926562008760 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 926562008761 ligand binding site [chemical binding]; other site 926562008762 flexible hinge region; other site 926562008763 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 926562008764 putative switch regulator; other site 926562008765 non-specific DNA interactions [nucleotide binding]; other site 926562008766 DNA binding site [nucleotide binding] 926562008767 sequence specific DNA binding site [nucleotide binding]; other site 926562008768 putative cAMP binding site [chemical binding]; other site 926562008769 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008770 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926562008771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562008772 active site 926562008773 phosphorylation site [posttranslational modification] 926562008774 intermolecular recognition site; other site 926562008775 dimerization interface [polypeptide binding]; other site 926562008776 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926562008777 DNA binding residues [nucleotide binding] 926562008778 dimerization interface [polypeptide binding]; other site 926562008779 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 926562008780 Histidine kinase; Region: HisKA_3; pfam07730 926562008781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562008782 ATP binding site [chemical binding]; other site 926562008783 Mg2+ binding site [ion binding]; other site 926562008784 G-X-G motif; other site 926562008785 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926562008786 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 926562008787 Right handed beta helix region; Region: Beta_helix; pfam13229 926562008788 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008789 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926562008790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562008791 active site 926562008792 phosphorylation site [posttranslational modification] 926562008793 intermolecular recognition site; other site 926562008794 dimerization interface [polypeptide binding]; other site 926562008795 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926562008796 DNA binding residues [nucleotide binding] 926562008797 dimerization interface [polypeptide binding]; other site 926562008798 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562008799 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 926562008800 binding surface 926562008801 TPR motif; other site 926562008802 Tetratricopeptide repeat; Region: TPR_12; pfam13424 926562008803 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 926562008804 Histidine kinase; Region: HisKA_3; pfam07730 926562008805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562008806 ATP binding site [chemical binding]; other site 926562008807 Mg2+ binding site [ion binding]; other site 926562008808 G-X-G motif; other site 926562008809 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 926562008810 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562008811 Interdomain contacts; other site 926562008812 Cytokine receptor motif; other site 926562008813 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562008814 Interdomain contacts; other site 926562008815 Cytokine receptor motif; other site 926562008816 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 926562008817 Interdomain contacts; other site 926562008818 Cytokine receptor motif; other site 926562008819 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 926562008820 Lamin Tail Domain; Region: LTD; pfam00932 926562008821 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 926562008822 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008823 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 926562008824 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 926562008825 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 926562008826 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008827 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 926562008828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562008829 active site 926562008830 phosphorylation site [posttranslational modification] 926562008831 intermolecular recognition site; other site 926562008832 dimerization interface [polypeptide binding]; other site 926562008833 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 926562008834 DNA binding residues [nucleotide binding] 926562008835 dimerization interface [polypeptide binding]; other site 926562008836 Histidine kinase; Region: HisKA_3; pfam07730 926562008837 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 926562008838 Mg2+ binding site [ion binding]; other site 926562008839 G-X-G motif; other site 926562008840 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263 926562008841 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 926562008842 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008843 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 926562008844 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 926562008845 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 926562008846 metal binding site [ion binding]; metal-binding site 926562008847 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 926562008848 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 926562008849 substrate binding site [chemical binding]; other site 926562008850 glutamase interaction surface [polypeptide binding]; other site 926562008851 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 926562008852 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 926562008853 catalytic residues [active] 926562008854 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 926562008855 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 926562008856 putative active site [active] 926562008857 oxyanion strand; other site 926562008858 catalytic triad [active] 926562008859 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 926562008860 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 926562008861 active site 926562008862 motif I; other site 926562008863 motif II; other site 926562008864 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 926562008865 putative active site pocket [active] 926562008866 4-fold oligomerization interface [polypeptide binding]; other site 926562008867 metal binding residues [ion binding]; metal-binding site 926562008868 3-fold/trimer interface [polypeptide binding]; other site 926562008869 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 926562008870 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 926562008871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562008872 homodimer interface [polypeptide binding]; other site 926562008873 catalytic residue [active] 926562008874 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 926562008875 histidinol dehydrogenase; Region: hisD; TIGR00069 926562008876 NAD binding site [chemical binding]; other site 926562008877 dimerization interface [polypeptide binding]; other site 926562008878 product binding site; other site 926562008879 substrate binding site [chemical binding]; other site 926562008880 zinc binding site [ion binding]; other site 926562008881 catalytic residues [active] 926562008882 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 926562008883 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 926562008884 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 926562008885 Lyase; Region: Lyase_1; pfam00206 926562008886 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 926562008887 active sites [active] 926562008888 tetramer interface [polypeptide binding]; other site 926562008889 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 926562008890 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 926562008891 metal binding site [ion binding]; metal-binding site 926562008892 dimer interface [polypeptide binding]; other site 926562008893 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 926562008894 nucleotide binding site [chemical binding]; other site 926562008895 N-acetyl-L-glutamate binding site [chemical binding]; other site 926562008896 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 926562008897 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 926562008898 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 926562008899 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 926562008900 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 926562008901 inhibitor-cofactor binding pocket; inhibition site 926562008902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 926562008903 catalytic residue [active] 926562008904 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 926562008905 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 926562008906 argininosuccinate synthase; Provisional; Region: PRK13820 926562008907 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 926562008908 Ligand Binding Site [chemical binding]; other site 926562008909 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 926562008910 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 926562008911 Coenzyme A binding pocket [chemical binding]; other site 926562008912 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 926562008913 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 926562008914 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 926562008915 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 926562008916 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 926562008917 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 926562008918 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 926562008919 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 926562008920 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 926562008921 catalytic residues [active] 926562008922 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 926562008923 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 926562008924 GatB domain; Region: GatB_Yqey; smart00845 926562008925 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 926562008926 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 926562008927 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 926562008928 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 926562008929 Ion transport protein; Region: Ion_trans; pfam00520 926562008930 Ion channel; Region: Ion_trans_2; pfam07885 926562008931 Double zinc ribbon; Region: DZR; pfam12773 926562008932 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 926562008933 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 926562008934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926562008935 Walker A/P-loop; other site 926562008936 ATP binding site [chemical binding]; other site 926562008937 Q-loop/lid; other site 926562008938 ABC transporter signature motif; other site 926562008939 Walker B; other site 926562008940 D-loop; other site 926562008941 H-loop/switch region; other site 926562008942 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 926562008943 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 926562008944 active site 926562008945 NTP binding site [chemical binding]; other site 926562008946 metal binding triad [ion binding]; metal-binding site 926562008947 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 926562008948 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 926562008949 Zn2+ binding site [ion binding]; other site 926562008950 Mg2+ binding site [ion binding]; other site 926562008951 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 926562008952 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 926562008953 putative metal binding site; other site 926562008954 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 926562008955 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 926562008956 dihydroorotase; Validated; Region: pyrC; PRK09357 926562008957 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 926562008958 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 926562008959 active site 926562008960 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 926562008961 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 926562008962 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 926562008963 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 926562008964 catalytic site [active] 926562008965 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 926562008966 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 926562008967 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 926562008968 FtsX-like permease family; Region: FtsX; pfam02687 926562008969 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 926562008970 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 926562008971 Walker A/P-loop; other site 926562008972 ATP binding site [chemical binding]; other site 926562008973 Q-loop/lid; other site 926562008974 ABC transporter signature motif; other site 926562008975 Walker B; other site 926562008976 D-loop; other site 926562008977 H-loop/switch region; other site 926562008978 CoA binding domain; Region: CoA_binding_2; pfam13380 926562008979 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 926562008980 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 926562008981 Response regulator receiver domain; Region: Response_reg; pfam00072 926562008982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562008983 active site 926562008984 phosphorylation site [posttranslational modification] 926562008985 intermolecular recognition site; other site 926562008986 dimerization interface [polypeptide binding]; other site 926562008987 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 926562008988 ATP binding site [chemical binding]; other site 926562008989 substrate interface [chemical binding]; other site 926562008990 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 926562008991 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 926562008992 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562008993 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562008994 dimer interface [polypeptide binding]; other site 926562008995 phosphorylation site [posttranslational modification] 926562008996 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562008997 ATP binding site [chemical binding]; other site 926562008998 Mg2+ binding site [ion binding]; other site 926562008999 G-X-G motif; other site 926562009000 Response regulator receiver domain; Region: Response_reg; pfam00072 926562009001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562009002 active site 926562009003 phosphorylation site [posttranslational modification] 926562009004 intermolecular recognition site; other site 926562009005 dimerization interface [polypeptide binding]; other site 926562009006 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 926562009007 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 926562009008 dimer interface [polypeptide binding]; other site 926562009009 phosphorylation site [posttranslational modification] 926562009010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 926562009011 ATP binding site [chemical binding]; other site 926562009012 Mg2+ binding site [ion binding]; other site 926562009013 G-X-G motif; other site 926562009014 Response regulator receiver domain; Region: Response_reg; pfam00072 926562009015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 926562009016 active site 926562009017 phosphorylation site [posttranslational modification] 926562009018 intermolecular recognition site; other site 926562009019 dimerization interface [polypeptide binding]; other site 926562009020 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 926562009021 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 926562009022 G1 box; other site 926562009023 putative GEF interaction site [polypeptide binding]; other site 926562009024 GTP/Mg2+ binding site [chemical binding]; other site 926562009025 Switch I region; other site 926562009026 G2 box; other site 926562009027 G3 box; other site 926562009028 Switch II region; other site 926562009029 G4 box; other site 926562009030 G5 box; other site 926562009031 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 926562009032 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 926562009033 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 926562009034 DNA binding residues [nucleotide binding] 926562009035 B12 binding domain; Region: B12-binding_2; pfam02607 926562009036 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 926562009037 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 926562009038 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 926562009039 DNA binding residues [nucleotide binding] 926562009040 phytoene desaturase; Region: crtI_fam; TIGR02734 926562009041 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 926562009042 hydroxyglutarate oxidase; Provisional; Region: PRK11728 926562009043 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 926562009044 active site lid residues [active] 926562009045 substrate binding pocket [chemical binding]; other site 926562009046 catalytic residues [active] 926562009047 substrate-Mg2+ binding site; other site 926562009048 aspartate-rich region 1; other site 926562009049 aspartate-rich region 2; other site 926562009050 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 926562009051 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 926562009052 active site 926562009053 metal binding site [ion binding]; metal-binding site 926562009054 nudix motif; other site 926562009055 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 926562009056 active site 926562009057 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 926562009058 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 926562009059 DNA photolyase; Region: DNA_photolyase; pfam00875 926562009060 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 926562009061 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 926562009062 Substrate binding site; other site 926562009063 Cupin domain; Region: Cupin_2; cl17218 926562009064 adenylate kinase; Reviewed; Region: adk; PRK00279 926562009065 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 926562009066 AMP-binding site [chemical binding]; other site 926562009067 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 926562009068 GTPase CgtA; Reviewed; Region: obgE; PRK12299 926562009069 GTP1/OBG; Region: GTP1_OBG; pfam01018 926562009070 Obg GTPase; Region: Obg; cd01898 926562009071 G1 box; other site 926562009072 GTP/Mg2+ binding site [chemical binding]; other site 926562009073 Switch I region; other site 926562009074 G2 box; other site 926562009075 G3 box; other site 926562009076 Switch II region; other site 926562009077 G4 box; other site 926562009078 G5 box; other site 926562009079 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 926562009080 active site 926562009081 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 926562009082 FOG: PKD repeat [General function prediction only]; Region: COG3291 926562009083 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 926562009084 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 926562009085 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 926562009086 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 926562009087 homodimer interface [polypeptide binding]; other site 926562009088 catalytic residues [active] 926562009089 NAD binding site [chemical binding]; other site 926562009090 substrate binding pocket [chemical binding]; other site 926562009091 flexible flap; other site 926562009092 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 926562009093 active site 926562009094 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 926562009095 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 926562009096 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 926562009097 ATP binding site [chemical binding]; other site 926562009098 putative Mg++ binding site [ion binding]; other site 926562009099 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 926562009100 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 926562009101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 926562009102 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 926562009103 AAA ATPase domain; Region: AAA_15; pfam13175 926562009104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 926562009105 Walker A/P-loop; other site 926562009106 ATP binding site [chemical binding]; other site