-- dump date 20140619_225053 -- class Genbank::misc_feature -- table misc_feature_note -- id note 324057000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 324057000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 324057000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057000004 Walker A motif; other site 324057000005 ATP binding site [chemical binding]; other site 324057000006 Walker B motif; other site 324057000007 arginine finger; other site 324057000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 324057000009 DnaA box-binding interface [nucleotide binding]; other site 324057000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 324057000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 324057000012 putative DNA binding surface [nucleotide binding]; other site 324057000013 dimer interface [polypeptide binding]; other site 324057000014 beta-clamp/clamp loader binding surface; other site 324057000015 beta-clamp/translesion DNA polymerase binding surface; other site 324057000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 324057000017 recombination protein F; Reviewed; Region: recF; PRK00064 324057000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 324057000019 Walker A/P-loop; other site 324057000020 ATP binding site [chemical binding]; other site 324057000021 Q-loop/lid; other site 324057000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057000023 ABC transporter signature motif; other site 324057000024 Walker B; other site 324057000025 D-loop; other site 324057000026 H-loop/switch region; other site 324057000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 324057000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057000029 Mg2+ binding site [ion binding]; other site 324057000030 G-X-G motif; other site 324057000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 324057000032 anchoring element; other site 324057000033 dimer interface [polypeptide binding]; other site 324057000034 ATP binding site [chemical binding]; other site 324057000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 324057000036 active site 324057000037 putative metal-binding site [ion binding]; other site 324057000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 324057000039 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 324057000040 DNA gyrase subunit A; Validated; Region: PRK05560 324057000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 324057000042 CAP-like domain; other site 324057000043 active site 324057000044 primary dimer interface [polypeptide binding]; other site 324057000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324057000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324057000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324057000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324057000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324057000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324057000051 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 324057000052 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057000053 Zn2+ binding site [ion binding]; other site 324057000054 Mg2+ binding site [ion binding]; other site 324057000055 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 324057000056 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 324057000057 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 324057000058 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057000059 catalytic residue [active] 324057000060 thymidylate kinase; Validated; Region: tmk; PRK00698 324057000061 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 324057000062 TMP-binding site; other site 324057000063 ATP-binding site [chemical binding]; other site 324057000064 Protein of unknown function (DUF970); Region: DUF970; pfam06153 324057000065 Protein of unknown function (DUF327); Region: DUF327; pfam03885 324057000066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057000067 DNA polymerase III subunit delta'; Validated; Region: PRK08058 324057000068 Walker A motif; other site 324057000069 ATP binding site [chemical binding]; other site 324057000070 Walker B motif; other site 324057000071 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 324057000072 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 324057000073 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324057000074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057000075 S-adenosylmethionine binding site [chemical binding]; other site 324057000076 Predicted methyltransferases [General function prediction only]; Region: COG0313 324057000077 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 324057000078 putative SAM binding site [chemical binding]; other site 324057000079 putative homodimer interface [polypeptide binding]; other site 324057000080 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 324057000081 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 324057000082 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057000083 Zn2+ binding site [ion binding]; other site 324057000084 Mg2+ binding site [ion binding]; other site 324057000085 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 324057000086 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 324057000087 active site 324057000088 Domain of unknown function (DUF348); Region: DUF348; pfam03990 324057000089 G5 domain; Region: G5; pfam07501 324057000090 3D domain; Region: 3D; cl01439 324057000091 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 324057000092 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 324057000093 putative active site [active] 324057000094 putative metal binding site [ion binding]; other site 324057000095 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 324057000096 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 324057000097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057000098 S-adenosylmethionine binding site [chemical binding]; other site 324057000099 YabG peptidase U57; Region: Peptidase_U57; cl05250 324057000100 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 324057000101 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 324057000102 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 324057000103 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 324057000104 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 324057000105 pur operon repressor; Provisional; Region: PRK09213 324057000106 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 324057000107 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057000108 active site 324057000109 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 324057000110 homotrimer interaction site [polypeptide binding]; other site 324057000111 putative active site [active] 324057000112 regulatory protein SpoVG; Reviewed; Region: PRK13259 324057000113 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 324057000114 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 324057000115 Substrate binding site; other site 324057000116 Mg++ binding site; other site 324057000117 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 324057000118 active site 324057000119 substrate binding site [chemical binding]; other site 324057000120 CoA binding site [chemical binding]; other site 324057000121 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 324057000122 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 324057000123 5S rRNA interface [nucleotide binding]; other site 324057000124 CTC domain interface [polypeptide binding]; other site 324057000125 L16 interface [polypeptide binding]; other site 324057000126 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 324057000127 putative active site [active] 324057000128 catalytic residue [active] 324057000129 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 324057000130 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 324057000131 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 324057000132 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057000133 ATP binding site [chemical binding]; other site 324057000134 putative Mg++ binding site [ion binding]; other site 324057000135 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057000136 nucleotide binding region [chemical binding]; other site 324057000137 ATP-binding site [chemical binding]; other site 324057000138 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 324057000139 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 324057000140 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 324057000141 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 324057000142 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 324057000143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 324057000144 stage V sporulation protein T; Region: spore_V_T; TIGR02851 324057000145 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 324057000146 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057000147 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057000148 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057000149 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057000150 alpha-galactosidase; Provisional; Region: PRK15076 324057000151 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 324057000152 NAD binding site [chemical binding]; other site 324057000153 sugar binding site [chemical binding]; other site 324057000154 divalent metal binding site [ion binding]; other site 324057000155 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 324057000156 dimer interface [polypeptide binding]; other site 324057000157 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 324057000158 glycerate kinase; Region: TIGR00045 324057000159 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 324057000160 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 324057000161 putative SAM binding site [chemical binding]; other site 324057000162 putative homodimer interface [polypeptide binding]; other site 324057000163 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 324057000164 homodimer interface [polypeptide binding]; other site 324057000165 metal binding site [ion binding]; metal-binding site 324057000166 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 324057000167 homodimer interface [polypeptide binding]; other site 324057000168 active site 324057000169 putative chemical substrate binding site [chemical binding]; other site 324057000170 metal binding site [ion binding]; metal-binding site 324057000171 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 324057000172 IHF dimer interface [polypeptide binding]; other site 324057000173 IHF - DNA interface [nucleotide binding]; other site 324057000174 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324057000175 RNA binding surface [nucleotide binding]; other site 324057000176 Protein of unknown function (DUF817); Region: DUF817; pfam05675 324057000177 YabP family; Region: YabP; cl06766 324057000178 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 324057000179 Septum formation initiator; Region: DivIC; pfam04977 324057000180 hypothetical protein; Provisional; Region: PRK08582 324057000181 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 324057000182 RNA binding site [nucleotide binding]; other site 324057000183 stage II sporulation protein E; Region: spore_II_E; TIGR02865 324057000184 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 324057000185 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 324057000186 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 324057000187 metal ion-dependent adhesion site (MIDAS); other site 324057000188 Protein kinase domain; Region: Pkinase; pfam00069 324057000189 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057000190 active site 324057000191 ATP binding site [chemical binding]; other site 324057000192 substrate binding site [chemical binding]; other site 324057000193 activation loop (A-loop); other site 324057000194 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 324057000195 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 324057000196 Ligand Binding Site [chemical binding]; other site 324057000197 TilS substrate C-terminal domain; Region: TilS_C; smart00977 324057000198 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057000199 active site 324057000200 FtsH Extracellular; Region: FtsH_ext; pfam06480 324057000201 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 324057000202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057000203 Walker A motif; other site 324057000204 ATP binding site [chemical binding]; other site 324057000205 Walker B motif; other site 324057000206 arginine finger; other site 324057000207 Peptidase family M41; Region: Peptidase_M41; pfam01434 324057000208 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 324057000209 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 324057000210 ligand binding site [chemical binding]; other site 324057000211 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 324057000212 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 324057000213 Walker A/P-loop; other site 324057000214 ATP binding site [chemical binding]; other site 324057000215 Q-loop/lid; other site 324057000216 ABC transporter signature motif; other site 324057000217 Walker B; other site 324057000218 D-loop; other site 324057000219 H-loop/switch region; other site 324057000220 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 324057000221 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 324057000222 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 324057000223 TM-ABC transporter signature motif; other site 324057000224 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 324057000225 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 324057000226 TM-ABC transporter signature motif; other site 324057000227 Quinolinate synthetase A protein; Region: NadA; pfam02445 324057000228 L-aspartate oxidase; Provisional; Region: PRK06175 324057000229 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 324057000230 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 324057000231 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 324057000232 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 324057000233 dimerization interface [polypeptide binding]; other site 324057000234 active site 324057000235 pantothenate kinase; Reviewed; Region: PRK13318 324057000236 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 324057000237 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 324057000238 dimerization interface [polypeptide binding]; other site 324057000239 domain crossover interface; other site 324057000240 redox-dependent activation switch; other site 324057000241 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 324057000242 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 324057000243 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 324057000244 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 324057000245 dimer interface [polypeptide binding]; other site 324057000246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057000247 catalytic residue [active] 324057000248 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 324057000249 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 324057000250 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 324057000251 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 324057000252 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 324057000253 glutamine binding [chemical binding]; other site 324057000254 catalytic triad [active] 324057000255 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 324057000256 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 324057000257 homodimer interface [polypeptide binding]; other site 324057000258 substrate-cofactor binding pocket; other site 324057000259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057000260 catalytic residue [active] 324057000261 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 324057000262 dihydropteroate synthase; Region: DHPS; TIGR01496 324057000263 substrate binding pocket [chemical binding]; other site 324057000264 dimer interface [polypeptide binding]; other site 324057000265 inhibitor binding site; inhibition site 324057000266 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 324057000267 homooctamer interface [polypeptide binding]; other site 324057000268 active site 324057000269 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 324057000270 catalytic center binding site [active] 324057000271 ATP binding site [chemical binding]; other site 324057000272 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057000273 non-specific DNA binding site [nucleotide binding]; other site 324057000274 salt bridge; other site 324057000275 sequence-specific DNA binding site [nucleotide binding]; other site 324057000276 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 324057000277 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 324057000278 FMN binding site [chemical binding]; other site 324057000279 active site 324057000280 catalytic residues [active] 324057000281 substrate binding site [chemical binding]; other site 324057000282 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 324057000283 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 324057000284 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 324057000285 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 324057000286 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 324057000287 dimer interface [polypeptide binding]; other site 324057000288 putative anticodon binding site; other site 324057000289 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 324057000290 motif 1; other site 324057000291 active site 324057000292 motif 2; other site 324057000293 motif 3; other site 324057000294 Predicted integral membrane protein [Function unknown]; Region: COG5542 324057000295 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 324057000296 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 324057000297 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 324057000298 Ligand binding site; other site 324057000299 Putative Catalytic site; other site 324057000300 DXD motif; other site 324057000301 Predicted membrane protein [Function unknown]; Region: COG2246 324057000302 GtrA-like protein; Region: GtrA; pfam04138 324057000303 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 324057000304 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057000305 Coenzyme A binding pocket [chemical binding]; other site 324057000306 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 324057000307 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 324057000308 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 324057000309 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 324057000310 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 324057000311 active site 324057000312 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 324057000313 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 324057000314 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 324057000315 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 324057000316 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 324057000317 active site 324057000318 multimer interface [polypeptide binding]; other site 324057000319 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 324057000320 predicted active site [active] 324057000321 catalytic triad [active] 324057000322 seryl-tRNA synthetase; Provisional; Region: PRK05431 324057000323 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 324057000324 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 324057000325 dimer interface [polypeptide binding]; other site 324057000326 active site 324057000327 motif 1; other site 324057000328 motif 2; other site 324057000329 motif 3; other site 324057000330 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 324057000331 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 324057000332 catalytic residues [active] 324057000333 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 324057000334 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324057000335 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 324057000336 active site 324057000337 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 324057000338 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057000339 Walker A/P-loop; other site 324057000340 ATP binding site [chemical binding]; other site 324057000341 Q-loop/lid; other site 324057000342 ABC transporter signature motif; other site 324057000343 Walker B; other site 324057000344 D-loop; other site 324057000345 H-loop/switch region; other site 324057000346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000347 dimer interface [polypeptide binding]; other site 324057000348 conserved gate region; other site 324057000349 ABC-ATPase subunit interface; other site 324057000350 DinB superfamily; Region: DinB_2; pfam12867 324057000351 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 324057000352 Low molecular weight phosphatase family; Region: LMWPc; cl00105 324057000353 active site 324057000354 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 324057000355 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 324057000356 nucleoside/Zn binding site; other site 324057000357 dimer interface [polypeptide binding]; other site 324057000358 catalytic motif [active] 324057000359 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 324057000360 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057000361 dimerization interface [polypeptide binding]; other site 324057000362 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057000363 putative active site [active] 324057000364 heme pocket [chemical binding]; other site 324057000365 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057000366 dimer interface [polypeptide binding]; other site 324057000367 phosphorylation site [posttranslational modification] 324057000368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057000369 ATP binding site [chemical binding]; other site 324057000370 Mg2+ binding site [ion binding]; other site 324057000371 G-X-G motif; other site 324057000372 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 324057000373 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 324057000374 NAD binding site [chemical binding]; other site 324057000375 active site 324057000376 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 324057000377 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324057000378 RNA binding surface [nucleotide binding]; other site 324057000379 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 324057000380 probable active site [active] 324057000381 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 324057000382 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 324057000383 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 324057000384 ligand binding site [chemical binding]; other site 324057000385 flagellar motor protein MotA; Validated; Region: PRK08124 324057000386 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 324057000387 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 324057000388 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 324057000389 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 324057000390 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 324057000391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057000392 putative substrate translocation pore; other site 324057000393 NlpC/P60 family; Region: NLPC_P60; pfam00877 324057000394 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 324057000395 Zn binding site [ion binding]; other site 324057000396 YwhD family; Region: YwhD; pfam08741 324057000397 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057000398 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 324057000399 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057000400 DNA binding residues [nucleotide binding] 324057000401 Putative zinc-finger; Region: zf-HC2; pfam13490 324057000402 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 324057000403 active site 324057000404 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 324057000405 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 324057000406 Subunit I/III interface [polypeptide binding]; other site 324057000407 Subunit III/IV interface [polypeptide binding]; other site 324057000408 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 324057000409 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 324057000410 D-pathway; other site 324057000411 Putative ubiquinol binding site [chemical binding]; other site 324057000412 Low-spin heme (heme b) binding site [chemical binding]; other site 324057000413 Putative water exit pathway; other site 324057000414 Binuclear center (heme o3/CuB) [ion binding]; other site 324057000415 K-pathway; other site 324057000416 Putative proton exit pathway; other site 324057000417 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 324057000418 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 324057000419 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 324057000420 Transglycosylase; Region: Transgly; pfam00912 324057000421 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 324057000422 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 324057000423 spermidine synthase; Provisional; Region: PRK00811 324057000424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057000425 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 324057000426 putative active site [active] 324057000427 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 324057000428 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 324057000429 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 324057000430 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 324057000431 active site 324057000432 HIGH motif; other site 324057000433 KMSK motif region; other site 324057000434 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 324057000435 tRNA binding surface [nucleotide binding]; other site 324057000436 anticodon binding site; other site 324057000437 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 324057000438 active site 324057000439 catalytic residues [active] 324057000440 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 324057000441 CTP synthetase; Validated; Region: pyrG; PRK05380 324057000442 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 324057000443 Catalytic site [active] 324057000444 active site 324057000445 UTP binding site [chemical binding]; other site 324057000446 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 324057000447 active site 324057000448 putative oxyanion hole; other site 324057000449 catalytic triad [active] 324057000450 Response regulator receiver domain; Region: Response_reg; pfam00072 324057000451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057000452 active site 324057000453 phosphorylation site [posttranslational modification] 324057000454 intermolecular recognition site; other site 324057000455 dimerization interface [polypeptide binding]; other site 324057000456 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 324057000457 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 324057000458 hinge; other site 324057000459 active site 324057000460 transcription termination factor Rho; Provisional; Region: rho; PRK09376 324057000461 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 324057000462 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 324057000463 RNA binding site [nucleotide binding]; other site 324057000464 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 324057000465 multimer interface [polypeptide binding]; other site 324057000466 Walker A motif; other site 324057000467 ATP binding site [chemical binding]; other site 324057000468 Walker B motif; other site 324057000469 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057000470 Radical SAM superfamily; Region: Radical_SAM; pfam04055 324057000471 FeS/SAM binding site; other site 324057000472 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 324057000473 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 324057000474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057000475 Walker B motif; other site 324057000476 arginine finger; other site 324057000477 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 324057000478 hypothetical protein; Validated; Region: PRK00153 324057000479 recombination protein RecR; Reviewed; Region: recR; PRK00076 324057000480 RecR protein; Region: RecR; pfam02132 324057000481 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 324057000482 putative active site [active] 324057000483 putative metal-binding site [ion binding]; other site 324057000484 tetramer interface [polypeptide binding]; other site 324057000485 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 324057000486 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 324057000487 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 324057000488 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 324057000489 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 324057000490 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 324057000491 Mg++ binding site [ion binding]; other site 324057000492 putative catalytic motif [active] 324057000493 substrate binding site [chemical binding]; other site 324057000494 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 324057000495 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 324057000496 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 324057000497 Walker A/P-loop; other site 324057000498 ATP binding site [chemical binding]; other site 324057000499 Q-loop/lid; other site 324057000500 ABC transporter signature motif; other site 324057000501 Walker B; other site 324057000502 D-loop; other site 324057000503 H-loop/switch region; other site 324057000504 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 324057000505 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057000506 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057000507 DNA binding residues [nucleotide binding] 324057000508 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 324057000509 HPr kinase/phosphorylase; Provisional; Region: PRK05428 324057000510 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 324057000511 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 324057000512 Hpr binding site; other site 324057000513 active site 324057000514 homohexamer subunit interaction site [polypeptide binding]; other site 324057000515 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 324057000516 pyrophosphatase PpaX; Provisional; Region: PRK13288 324057000517 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057000518 motif II; other site 324057000519 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 324057000520 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 324057000521 trimer interface [polypeptide binding]; other site 324057000522 active site 324057000523 substrate binding site [chemical binding]; other site 324057000524 CoA binding site [chemical binding]; other site 324057000525 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 324057000526 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 324057000527 dimer interface [polypeptide binding]; other site 324057000528 motif 1; other site 324057000529 active site 324057000530 motif 2; other site 324057000531 motif 3; other site 324057000532 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 324057000533 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 324057000534 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 324057000535 histidinol dehydrogenase; Region: hisD; TIGR00069 324057000536 NAD binding site [chemical binding]; other site 324057000537 dimerization interface [polypeptide binding]; other site 324057000538 product binding site; other site 324057000539 substrate binding site [chemical binding]; other site 324057000540 zinc binding site [ion binding]; other site 324057000541 catalytic residues [active] 324057000542 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 324057000543 putative active site pocket [active] 324057000544 4-fold oligomerization interface [polypeptide binding]; other site 324057000545 metal binding residues [ion binding]; metal-binding site 324057000546 3-fold/trimer interface [polypeptide binding]; other site 324057000547 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 324057000548 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 324057000549 putative active site [active] 324057000550 oxyanion strand; other site 324057000551 catalytic triad [active] 324057000552 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 324057000553 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 324057000554 substrate binding site [chemical binding]; other site 324057000555 glutamase interaction surface [polypeptide binding]; other site 324057000556 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 324057000557 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 324057000558 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 324057000559 metal binding site [ion binding]; metal-binding site 324057000560 histidinol-phosphatase; Provisional; Region: PRK07328 324057000561 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 324057000562 active site 324057000563 dimer interface [polypeptide binding]; other site 324057000564 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 324057000565 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 324057000566 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057000567 active site 324057000568 TPR repeat; Region: TPR_11; pfam13414 324057000569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057000570 TPR motif; other site 324057000571 binding surface 324057000572 Tetratricopeptide repeat; Region: TPR_16; pfam13432 324057000573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057000574 TPR motif; other site 324057000575 binding surface 324057000576 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057000577 TPR motif; other site 324057000578 binding surface 324057000579 HEAT repeats; Region: HEAT_2; pfam13646 324057000580 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 324057000581 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 324057000582 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057000583 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 324057000584 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 324057000585 nucleotide binding site [chemical binding]; other site 324057000586 Butyrate kinase [Energy production and conversion]; Region: COG3426 324057000587 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 324057000588 shikimate kinase; Reviewed; Region: aroK; PRK00131 324057000589 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 324057000590 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 324057000591 phosphate binding site [ion binding]; other site 324057000592 putative substrate binding pocket [chemical binding]; other site 324057000593 dimer interface [polypeptide binding]; other site 324057000594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 324057000595 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 324057000596 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 324057000597 dimerization domain swap beta strand [polypeptide binding]; other site 324057000598 regulatory protein interface [polypeptide binding]; other site 324057000599 active site 324057000600 regulatory phosphorylation site [posttranslational modification]; other site 324057000601 Clp protease; Region: CLP_protease; pfam00574 324057000602 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 324057000603 oligomer interface [polypeptide binding]; other site 324057000604 active site residues [active] 324057000605 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 324057000606 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 324057000607 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 324057000608 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 324057000609 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 324057000610 Phosphoglycerate kinase; Region: PGK; pfam00162 324057000611 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 324057000612 substrate binding site [chemical binding]; other site 324057000613 hinge regions; other site 324057000614 ADP binding site [chemical binding]; other site 324057000615 catalytic site [active] 324057000616 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 324057000617 triosephosphate isomerase; Provisional; Region: PRK14565 324057000618 substrate binding site [chemical binding]; other site 324057000619 dimer interface [polypeptide binding]; other site 324057000620 catalytic triad [active] 324057000621 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 324057000622 phosphoglyceromutase; Provisional; Region: PRK05434 324057000623 enolase; Provisional; Region: eno; PRK00077 324057000624 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 324057000625 dimer interface [polypeptide binding]; other site 324057000626 metal binding site [ion binding]; metal-binding site 324057000627 substrate binding pocket [chemical binding]; other site 324057000628 Preprotein translocase SecG subunit; Region: SecG; pfam03840 324057000629 ribonuclease R; Region: RNase_R; TIGR02063 324057000630 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 324057000631 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 324057000632 RNB domain; Region: RNB; pfam00773 324057000633 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 324057000634 RNA binding site [nucleotide binding]; other site 324057000635 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 324057000636 DNA-binding site [nucleotide binding]; DNA binding site 324057000637 RNA-binding motif; other site 324057000638 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 324057000639 SmpB-tmRNA interface; other site 324057000640 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057000641 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057000642 dimerization interface [polypeptide binding]; other site 324057000643 Histidine kinase; Region: His_kinase; pfam06580 324057000644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057000645 ATP binding site [chemical binding]; other site 324057000646 Mg2+ binding site [ion binding]; other site 324057000647 G-X-G motif; other site 324057000648 Response regulator receiver domain; Region: Response_reg; pfam00072 324057000649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057000650 active site 324057000651 phosphorylation site [posttranslational modification] 324057000652 intermolecular recognition site; other site 324057000653 dimerization interface [polypeptide binding]; other site 324057000654 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057000655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057000656 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057000657 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057000658 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057000659 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057000660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000661 dimer interface [polypeptide binding]; other site 324057000662 conserved gate region; other site 324057000663 putative PBP binding loops; other site 324057000664 ABC-ATPase subunit interface; other site 324057000665 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057000666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000667 dimer interface [polypeptide binding]; other site 324057000668 conserved gate region; other site 324057000669 putative PBP binding loops; other site 324057000670 ABC-ATPase subunit interface; other site 324057000671 Melibiase; Region: Melibiase; pfam02065 324057000672 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057000673 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324057000674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057000675 ATP binding site [chemical binding]; other site 324057000676 Mg2+ binding site [ion binding]; other site 324057000677 G-X-G motif; other site 324057000678 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 324057000679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057000680 active site 324057000681 phosphorylation site [posttranslational modification] 324057000682 intermolecular recognition site; other site 324057000683 dimerization interface [polypeptide binding]; other site 324057000684 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 324057000685 S-layer homology domain; Region: SLH; pfam00395 324057000686 S-layer homology domain; Region: SLH; pfam00395 324057000687 S-layer homology domain; Region: SLH; pfam00395 324057000688 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057000689 Histidine kinase; Region: His_kinase; pfam06580 324057000690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057000691 ATP binding site [chemical binding]; other site 324057000692 Mg2+ binding site [ion binding]; other site 324057000693 G-X-G motif; other site 324057000694 Response regulator receiver domain; Region: Response_reg; pfam00072 324057000695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057000696 active site 324057000697 phosphorylation site [posttranslational modification] 324057000698 intermolecular recognition site; other site 324057000699 dimerization interface [polypeptide binding]; other site 324057000700 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057000701 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057000702 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057000703 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057000704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000705 dimer interface [polypeptide binding]; other site 324057000706 conserved gate region; other site 324057000707 ABC-ATPase subunit interface; other site 324057000708 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057000709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000710 dimer interface [polypeptide binding]; other site 324057000711 conserved gate region; other site 324057000712 putative PBP binding loops; other site 324057000713 ABC-ATPase subunit interface; other site 324057000714 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057000715 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057000716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057000717 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057000718 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057000719 intersubunit interface [polypeptide binding]; other site 324057000720 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 324057000721 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057000722 ABC-ATPase subunit interface; other site 324057000723 dimer interface [polypeptide binding]; other site 324057000724 putative PBP binding regions; other site 324057000725 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 324057000726 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057000727 ABC-ATPase subunit interface; other site 324057000728 dimer interface [polypeptide binding]; other site 324057000729 putative PBP binding regions; other site 324057000730 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057000731 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057000732 intersubunit interface [polypeptide binding]; other site 324057000733 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057000734 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057000735 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 324057000736 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 324057000737 putative active site; other site 324057000738 catalytic triad [active] 324057000739 putative dimer interface [polypeptide binding]; other site 324057000740 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 324057000741 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 324057000742 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 324057000743 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057000744 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 324057000745 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057000746 classical (c) SDRs; Region: SDR_c; cd05233 324057000747 NAD(P) binding site [chemical binding]; other site 324057000748 active site 324057000749 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 324057000750 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057000751 motif II; other site 324057000752 4-aminobutyrate aminotransferase; Provisional; Region: PRK06082 324057000753 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324057000754 inhibitor-cofactor binding pocket; inhibition site 324057000755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057000756 catalytic residue [active] 324057000757 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324057000758 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 324057000759 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 324057000760 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057000761 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 324057000762 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 324057000763 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663 324057000764 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057000765 metal binding site [ion binding]; metal-binding site 324057000766 ligand binding site [chemical binding]; other site 324057000767 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057000768 metal binding site [ion binding]; metal-binding site 324057000769 ligand binding site [chemical binding]; other site 324057000770 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057000771 metal binding site [ion binding]; metal-binding site 324057000772 ligand binding site [chemical binding]; other site 324057000773 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057000774 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057000775 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057000776 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 324057000777 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 324057000778 Ca binding site [ion binding]; other site 324057000779 carbohydrate binding site [chemical binding]; other site 324057000780 S-layer homology domain; Region: SLH; pfam00395 324057000781 S-layer homology domain; Region: SLH; pfam00395 324057000782 S-layer homology domain; Region: SLH; pfam00395 324057000783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057000784 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057000785 putative substrate translocation pore; other site 324057000786 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 324057000787 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057000788 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 324057000789 active site 324057000790 metal binding site [ion binding]; metal-binding site 324057000791 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 324057000792 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057000793 putative DNA binding site [nucleotide binding]; other site 324057000794 putative Zn2+ binding site [ion binding]; other site 324057000795 AsnC family; Region: AsnC_trans_reg; pfam01037 324057000796 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 324057000797 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057000798 Zn2+ binding site [ion binding]; other site 324057000799 Mg2+ binding site [ion binding]; other site 324057000800 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 324057000801 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 324057000802 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 324057000803 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 324057000804 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 324057000805 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057000806 dimerization interface [polypeptide binding]; other site 324057000807 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057000808 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057000809 dimer interface [polypeptide binding]; other site 324057000810 putative CheW interface [polypeptide binding]; other site 324057000811 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 324057000812 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057000813 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057000814 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057000815 dimerization interface [polypeptide binding]; other site 324057000816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057000817 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057000818 putative substrate translocation pore; other site 324057000819 Predicted transcriptional regulators [Transcription]; Region: COG1733 324057000820 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 324057000821 azoreductase; Reviewed; Region: PRK00170 324057000822 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 324057000823 Predicted transcriptional regulators [Transcription]; Region: COG1733 324057000824 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 324057000825 DoxX-like family; Region: DoxX_2; pfam13564 324057000826 Domain of unknown function DUF302; Region: DUF302; pfam03625 324057000827 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057000828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057000829 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057000830 dimerization interface [polypeptide binding]; other site 324057000831 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324057000832 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057000833 Coenzyme A binding pocket [chemical binding]; other site 324057000834 Domain of unknown function (DUF334); Region: DUF334; pfam03904 324057000835 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057000836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057000837 active site 324057000838 phosphorylation site [posttranslational modification] 324057000839 intermolecular recognition site; other site 324057000840 dimerization interface [polypeptide binding]; other site 324057000841 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057000842 DNA binding site [nucleotide binding] 324057000843 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057000844 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057000845 dimerization interface [polypeptide binding]; other site 324057000846 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057000847 dimer interface [polypeptide binding]; other site 324057000848 phosphorylation site [posttranslational modification] 324057000849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057000850 ATP binding site [chemical binding]; other site 324057000851 Mg2+ binding site [ion binding]; other site 324057000852 G-X-G motif; other site 324057000853 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 324057000854 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057000855 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 324057000856 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 324057000857 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 324057000858 active site 324057000859 membrane protein; Provisional; Region: PRK14404 324057000860 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 324057000861 Asp-box motif; other site 324057000862 Bacterial Ig-like domain; Region: Big_5; pfam13205 324057000863 Bacterial Ig-like domain; Region: Big_5; pfam13205 324057000864 Bacterial Ig-like domain; Region: Big_5; pfam13205 324057000865 Bacterial Ig-like domain; Region: Big_5; pfam13205 324057000866 Bacterial Ig-like domain; Region: Big_5; pfam13205 324057000867 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 324057000868 dockerin binding interface; other site 324057000869 S-layer homology domain; Region: SLH; pfam00395 324057000870 S-layer homology domain; Region: SLH; pfam00395 324057000871 S-layer homology domain; Region: SLH; pfam00395 324057000872 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057000873 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057000874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 324057000875 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057000876 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057000877 active site 324057000878 catalytic tetrad [active] 324057000879 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 324057000880 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 324057000881 active site 324057000882 nucleophile elbow; other site 324057000883 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 324057000884 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 324057000885 HPP family; Region: HPP; pfam04982 324057000886 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 324057000887 MATE family multidrug exporter; Provisional; Region: PRK10189 324057000888 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 324057000889 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324057000890 Walker A/P-loop; other site 324057000891 ATP binding site [chemical binding]; other site 324057000892 Q-loop/lid; other site 324057000893 ABC transporter signature motif; other site 324057000894 Walker B; other site 324057000895 D-loop; other site 324057000896 H-loop/switch region; other site 324057000897 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324057000898 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 324057000899 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324057000900 Walker A/P-loop; other site 324057000901 ATP binding site [chemical binding]; other site 324057000902 Q-loop/lid; other site 324057000903 ABC transporter signature motif; other site 324057000904 Walker B; other site 324057000905 D-loop; other site 324057000906 H-loop/switch region; other site 324057000907 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324057000908 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 324057000909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000910 dimer interface [polypeptide binding]; other site 324057000911 conserved gate region; other site 324057000912 putative PBP binding loops; other site 324057000913 ABC-ATPase subunit interface; other site 324057000914 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 324057000915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000916 dimer interface [polypeptide binding]; other site 324057000917 conserved gate region; other site 324057000918 putative PBP binding loops; other site 324057000919 ABC-ATPase subunit interface; other site 324057000920 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 324057000921 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 324057000922 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057000923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057000924 active site 324057000925 phosphorylation site [posttranslational modification] 324057000926 intermolecular recognition site; other site 324057000927 dimerization interface [polypeptide binding]; other site 324057000928 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057000929 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057000930 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057000931 dimerization interface [polypeptide binding]; other site 324057000932 Histidine kinase; Region: His_kinase; pfam06580 324057000933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057000934 ATP binding site [chemical binding]; other site 324057000935 Mg2+ binding site [ion binding]; other site 324057000936 G-X-G motif; other site 324057000937 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057000938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000939 dimer interface [polypeptide binding]; other site 324057000940 conserved gate region; other site 324057000941 ABC-ATPase subunit interface; other site 324057000942 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057000943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000944 dimer interface [polypeptide binding]; other site 324057000945 conserved gate region; other site 324057000946 putative PBP binding loops; other site 324057000947 ABC-ATPase subunit interface; other site 324057000948 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057000949 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057000950 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 324057000951 putative hydrophobic ligand binding site [chemical binding]; other site 324057000952 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057000953 dimerization interface [polypeptide binding]; other site 324057000954 putative DNA binding site [nucleotide binding]; other site 324057000955 putative Zn2+ binding site [ion binding]; other site 324057000956 DoxX-like family; Region: DoxX_2; pfam13564 324057000957 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057000958 dockerin binding interface; other site 324057000959 S-layer homology domain; Region: SLH; pfam00395 324057000960 S-layer homology domain; Region: SLH; pfam00395 324057000961 S-layer homology domain; Region: SLH; pfam00395 324057000962 amidase; Provisional; Region: PRK06828 324057000963 Amidase; Region: Amidase; pfam01425 324057000964 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 324057000965 Predicted transcriptional regulator [Transcription]; Region: COG1959 324057000966 Transcriptional regulator; Region: Rrf2; pfam02082 324057000967 DinB superfamily; Region: DinB_2; pfam12867 324057000968 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 324057000969 Predicted transcriptional regulator [Transcription]; Region: COG2378 324057000970 HTH domain; Region: HTH_11; pfam08279 324057000971 WYL domain; Region: WYL; pfam13280 324057000972 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057000973 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 324057000974 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 324057000975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000976 dimer interface [polypeptide binding]; other site 324057000977 conserved gate region; other site 324057000978 putative PBP binding loops; other site 324057000979 ABC-ATPase subunit interface; other site 324057000980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057000981 dimer interface [polypeptide binding]; other site 324057000982 conserved gate region; other site 324057000983 ABC-ATPase subunit interface; other site 324057000984 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 324057000985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057000986 Walker A/P-loop; other site 324057000987 ATP binding site [chemical binding]; other site 324057000988 Q-loop/lid; other site 324057000989 ABC transporter signature motif; other site 324057000990 Walker B; other site 324057000991 D-loop; other site 324057000992 H-loop/switch region; other site 324057000993 TOBE domain; Region: TOBE; cl01440 324057000994 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 324057000995 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 324057000996 active site 324057000997 PHP-associated; Region: PHP_C; pfam13263 324057000998 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 324057000999 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 324057001000 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 324057001001 putative active site [active] 324057001002 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 324057001003 DNA methylase; Region: N6_N4_Mtase; cl17433 324057001004 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 324057001005 PLD-like domain; Region: PLDc_2; pfam13091 324057001006 putative homodimer interface [polypeptide binding]; other site 324057001007 putative active site [active] 324057001008 catalytic site [active] 324057001009 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 324057001010 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057001011 ATP binding site [chemical binding]; other site 324057001012 putative Mg++ binding site [ion binding]; other site 324057001013 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057001014 nucleotide binding region [chemical binding]; other site 324057001015 ATP-binding site [chemical binding]; other site 324057001016 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 324057001017 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 324057001018 active site 324057001019 8-oxo-dGMP binding site [chemical binding]; other site 324057001020 nudix motif; other site 324057001021 metal binding site [ion binding]; metal-binding site 324057001022 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 324057001023 NPCBM/NEW2 domain; Region: NPCBM; cl07060 324057001024 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 324057001025 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 324057001026 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 324057001027 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 324057001028 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 324057001029 active site 324057001030 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 324057001031 DNA-binding site [nucleotide binding]; DNA binding site 324057001032 RNA-binding motif; other site 324057001033 Cold-inducible protein YdjO; Region: YdjO; pfam14169 324057001034 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 324057001035 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 324057001036 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057001037 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057001038 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057001039 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057001040 dimerization interface [polypeptide binding]; other site 324057001041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057001042 short chain dehydrogenase; Validated; Region: PRK07069 324057001043 NAD(P) binding site [chemical binding]; other site 324057001044 active site 324057001045 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057001046 classical (c) SDRs; Region: SDR_c; cd05233 324057001047 NAD(P) binding site [chemical binding]; other site 324057001048 active site 324057001049 Predicted multitransmembrane protein [Function unknown]; Region: COG5438 324057001050 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 324057001051 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057001052 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 324057001053 active site 324057001054 metal binding site [ion binding]; metal-binding site 324057001055 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 324057001056 S-layer homology domain; Region: SLH; pfam00395 324057001057 S-layer homology domain; Region: SLH; pfam00395 324057001058 S-layer homology domain; Region: SLH; pfam00395 324057001059 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 324057001060 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 324057001061 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057001062 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057001063 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 324057001064 active site 324057001065 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 324057001066 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 324057001067 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 324057001068 Amino acid permease; Region: AA_permease_2; pfam13520 324057001069 K+ potassium transporter; Region: K_trans; cl15781 324057001070 MMPL family; Region: MMPL; pfam03176 324057001071 MMPL family; Region: MMPL; pfam03176 324057001072 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 324057001073 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057001074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057001075 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057001076 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057001077 active site 324057001078 catalytic tetrad [active] 324057001079 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 324057001080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057001081 putative substrate translocation pore; other site 324057001082 Predicted transcriptional regulators [Transcription]; Region: COG1733 324057001083 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 324057001084 conserved repeat domain; Region: B_ant_repeat; TIGR01451 324057001085 conserved repeat domain; Region: B_ant_repeat; TIGR01451 324057001086 Domain of unknown function DUF11; Region: DUF11; cl17728 324057001087 conserved repeat domain; Region: B_ant_repeat; TIGR01451 324057001088 conserved repeat domain; Region: B_ant_repeat; TIGR01451 324057001089 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 324057001090 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057001091 Walker A motif; other site 324057001092 ATP binding site [chemical binding]; other site 324057001093 Walker B motif; other site 324057001094 arginine finger; other site 324057001095 Peptidase family M41; Region: Peptidase_M41; pfam01434 324057001096 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 324057001097 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057001098 motif II; other site 324057001099 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 324057001100 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 324057001101 substrate binding site [chemical binding]; other site 324057001102 dimer interface [polypeptide binding]; other site 324057001103 ATP binding site [chemical binding]; other site 324057001104 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 324057001105 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 324057001106 NodB motif; other site 324057001107 active site 324057001108 catalytic site [active] 324057001109 metal binding site [ion binding]; metal-binding site 324057001110 Transcriptional regulators [Transcription]; Region: GntR; COG1802 324057001111 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057001112 DNA-binding site [nucleotide binding]; DNA binding site 324057001113 FCD domain; Region: FCD; pfam07729 324057001114 mannonate dehydratase; Provisional; Region: PRK03906 324057001115 mannonate dehydratase; Region: uxuA; TIGR00695 324057001116 D-mannonate oxidoreductase; Provisional; Region: PRK08277 324057001117 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 324057001118 putative NAD(P) binding site [chemical binding]; other site 324057001119 active site 324057001120 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057001121 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057001122 active site 324057001123 catalytic tetrad [active] 324057001124 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 324057001125 DNA binding residues [nucleotide binding] 324057001126 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 324057001127 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 324057001128 transglutaminase; Provisional; Region: tgl; PRK03187 324057001129 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057001130 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057001131 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001132 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057001133 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057001134 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057001135 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057001136 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 324057001137 hypothetical protein; Provisional; Region: PRK08236 324057001138 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 324057001139 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 324057001140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057001141 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057001142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057001143 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057001144 putative substrate translocation pore; other site 324057001145 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 324057001146 Chain length determinant protein; Region: Wzz; cl15801 324057001147 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 324057001148 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 324057001149 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 324057001150 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 324057001151 NAD(P) binding site [chemical binding]; other site 324057001152 homodimer interface [polypeptide binding]; other site 324057001153 substrate binding site [chemical binding]; other site 324057001154 active site 324057001155 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 324057001156 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 324057001157 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 324057001158 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057001159 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 324057001160 putative ADP-binding pocket [chemical binding]; other site 324057001161 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 324057001162 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 324057001163 trimer interface [polypeptide binding]; other site 324057001164 active site 324057001165 substrate binding site [chemical binding]; other site 324057001166 CoA binding site [chemical binding]; other site 324057001167 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324057001168 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057001169 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057001170 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 324057001171 putative NAD(P) binding site [chemical binding]; other site 324057001172 active site 324057001173 putative substrate binding site [chemical binding]; other site 324057001174 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057001175 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 324057001176 putative ADP-binding pocket [chemical binding]; other site 324057001177 Bacterial sugar transferase; Region: Bac_transf; pfam02397 324057001178 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 324057001179 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 324057001180 putative trimer interface [polypeptide binding]; other site 324057001181 putative CoA binding site [chemical binding]; other site 324057001182 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 324057001183 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 324057001184 inhibitor-cofactor binding pocket; inhibition site 324057001185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057001186 catalytic residue [active] 324057001187 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 324057001188 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 324057001189 active site 324057001190 tetramer interface; other site 324057001191 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 324057001192 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 324057001193 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 324057001194 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 324057001195 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 324057001196 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057001197 Coenzyme A binding pocket [chemical binding]; other site 324057001198 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 324057001199 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057001200 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057001201 DNA binding residues [nucleotide binding] 324057001202 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 324057001203 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 324057001204 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 324057001205 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 324057001206 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057001207 putative DNA binding site [nucleotide binding]; other site 324057001208 putative Zn2+ binding site [ion binding]; other site 324057001209 AsnC family; Region: AsnC_trans_reg; pfam01037 324057001210 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 324057001211 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 324057001212 Protein of unknown function (DUF4023); Region: DUF4023; pfam13215 324057001213 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 324057001214 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 324057001215 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 324057001216 pentamer interface [polypeptide binding]; other site 324057001217 dodecaamer interface [polypeptide binding]; other site 324057001218 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 324057001219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057001220 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057001221 putative substrate translocation pore; other site 324057001222 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 324057001223 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 324057001224 Cache domain; Region: Cache_1; pfam02743 324057001225 HAMP domain; Region: HAMP; pfam00672 324057001226 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 324057001227 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057001228 metal binding site [ion binding]; metal-binding site 324057001229 active site 324057001230 I-site; other site 324057001231 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 324057001232 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 324057001233 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057001234 ABC-ATPase subunit interface; other site 324057001235 dimer interface [polypeptide binding]; other site 324057001236 putative PBP binding regions; other site 324057001237 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 324057001238 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057001239 ABC-ATPase subunit interface; other site 324057001240 dimer interface [polypeptide binding]; other site 324057001241 putative PBP binding regions; other site 324057001242 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 324057001243 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 324057001244 siderophore binding site; other site 324057001245 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057001246 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001247 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057001248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057001249 dimer interface [polypeptide binding]; other site 324057001250 conserved gate region; other site 324057001251 putative PBP binding loops; other site 324057001252 ABC-ATPase subunit interface; other site 324057001253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057001254 dimer interface [polypeptide binding]; other site 324057001255 conserved gate region; other site 324057001256 putative PBP binding loops; other site 324057001257 ABC-ATPase subunit interface; other site 324057001258 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057001259 dimerization interface [polypeptide binding]; other site 324057001260 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 324057001261 Histidine kinase; Region: His_kinase; pfam06580 324057001262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057001263 ATP binding site [chemical binding]; other site 324057001264 Mg2+ binding site [ion binding]; other site 324057001265 G-X-G motif; other site 324057001266 Response regulator receiver domain; Region: Response_reg; pfam00072 324057001267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057001268 active site 324057001269 phosphorylation site [posttranslational modification] 324057001270 intermolecular recognition site; other site 324057001271 dimerization interface [polypeptide binding]; other site 324057001272 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057001273 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001274 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001275 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057001276 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057001277 Melibiase; Region: Melibiase; pfam02065 324057001278 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 324057001279 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 324057001280 putative active site [active] 324057001281 FaeA-like protein; Region: FaeA; pfam04703 324057001282 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 324057001283 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 324057001284 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 324057001285 Walker A/P-loop; other site 324057001286 ATP binding site [chemical binding]; other site 324057001287 Q-loop/lid; other site 324057001288 ABC transporter signature motif; other site 324057001289 Walker B; other site 324057001290 D-loop; other site 324057001291 H-loop/switch region; other site 324057001292 TOBE domain; Region: TOBE_2; pfam08402 324057001293 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324057001294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057001295 dimer interface [polypeptide binding]; other site 324057001296 conserved gate region; other site 324057001297 putative PBP binding loops; other site 324057001298 ABC-ATPase subunit interface; other site 324057001299 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324057001300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057001301 dimer interface [polypeptide binding]; other site 324057001302 conserved gate region; other site 324057001303 putative PBP binding loops; other site 324057001304 ABC-ATPase subunit interface; other site 324057001305 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 324057001306 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 324057001307 S-layer homology domain; Region: SLH; pfam00395 324057001308 S-layer homology domain; Region: SLH; pfam00395 324057001309 S-layer homology domain; Region: SLH; pfam00395 324057001310 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 324057001311 Chain length determinant protein; Region: Wzz; cl15801 324057001312 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 324057001313 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 324057001314 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 324057001315 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 324057001316 active site 324057001317 tetramer interface; other site 324057001318 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 324057001319 Bacterial sugar transferase; Region: Bac_transf; pfam02397 324057001320 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 324057001321 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 324057001322 NADP binding site [chemical binding]; other site 324057001323 active site 324057001324 putative substrate binding site [chemical binding]; other site 324057001325 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 324057001326 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 324057001327 NADP-binding site; other site 324057001328 homotetramer interface [polypeptide binding]; other site 324057001329 substrate binding site [chemical binding]; other site 324057001330 homodimer interface [polypeptide binding]; other site 324057001331 active site 324057001332 putative glycosyl transferase; Provisional; Region: PRK10307 324057001333 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 324057001334 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 324057001335 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 324057001336 trimer interface [polypeptide binding]; other site 324057001337 active site 324057001338 substrate binding site [chemical binding]; other site 324057001339 CoA binding site [chemical binding]; other site 324057001340 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057001341 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057001342 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 324057001343 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324057001344 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 324057001345 active site 324057001346 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 324057001347 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057001348 active site 324057001349 Cupin domain; Region: Cupin_2; cl17218 324057001350 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 324057001351 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 324057001352 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 324057001353 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 324057001354 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 324057001355 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 324057001356 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 324057001357 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 324057001358 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057001359 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057001360 Predicted integral membrane protein [Function unknown]; Region: COG5652 324057001361 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 324057001362 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 324057001363 active site 324057001364 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057001365 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001366 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 324057001367 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 324057001368 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 324057001369 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 324057001370 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 324057001371 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057001372 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324057001373 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 324057001374 Walker A/P-loop; other site 324057001375 ATP binding site [chemical binding]; other site 324057001376 Q-loop/lid; other site 324057001377 ABC transporter signature motif; other site 324057001378 Walker B; other site 324057001379 D-loop; other site 324057001380 H-loop/switch region; other site 324057001381 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 324057001382 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 324057001383 Divergent PAP2 family; Region: DUF212; cl00855 324057001384 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057001385 HAMP domain; Region: HAMP; pfam00672 324057001386 Histidine kinase; Region: His_kinase; pfam06580 324057001387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057001388 ATP binding site [chemical binding]; other site 324057001389 Mg2+ binding site [ion binding]; other site 324057001390 G-X-G motif; other site 324057001391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057001392 active site 324057001393 phosphorylation site [posttranslational modification] 324057001394 intermolecular recognition site; other site 324057001395 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057001396 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001397 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057001398 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057001399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057001400 dimer interface [polypeptide binding]; other site 324057001401 conserved gate region; other site 324057001402 putative PBP binding loops; other site 324057001403 ABC-ATPase subunit interface; other site 324057001404 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057001405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057001406 dimer interface [polypeptide binding]; other site 324057001407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057001408 ABC-ATPase subunit interface; other site 324057001409 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 324057001410 putative substrate binding site [chemical binding]; other site 324057001411 active site 324057001412 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 324057001413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057001414 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057001415 putative substrate translocation pore; other site 324057001416 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 324057001417 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 324057001418 putative active site [active] 324057001419 putative metal binding site [ion binding]; other site 324057001420 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 324057001421 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057001422 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 324057001423 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057001424 DNA binding residues [nucleotide binding] 324057001425 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 324057001426 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 324057001427 intersubunit interface [polypeptide binding]; other site 324057001428 active site 324057001429 catalytic residue [active] 324057001430 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 324057001431 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 324057001432 Sulfate transporter family; Region: Sulfate_transp; pfam00916 324057001433 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 324057001434 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 324057001435 active site 324057001436 catalytic residues [active] 324057001437 SurA N-terminal domain; Region: SurA_N_3; cl07813 324057001438 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 324057001439 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 324057001440 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 324057001441 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 324057001442 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057001443 metal binding site [ion binding]; metal-binding site 324057001444 active site 324057001445 I-site; other site 324057001446 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 324057001447 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 324057001448 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057001449 Zn2+ binding site [ion binding]; other site 324057001450 Mg2+ binding site [ion binding]; other site 324057001451 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057001452 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057001453 active site 324057001454 catalytic tetrad [active] 324057001455 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 324057001456 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057001457 dimerization interface [polypeptide binding]; other site 324057001458 PAS domain S-box; Region: sensory_box; TIGR00229 324057001459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057001460 putative active site [active] 324057001461 heme pocket [chemical binding]; other site 324057001462 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324057001463 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057001464 putative active site [active] 324057001465 heme pocket [chemical binding]; other site 324057001466 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057001467 dimer interface [polypeptide binding]; other site 324057001468 phosphorylation site [posttranslational modification] 324057001469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057001470 ATP binding site [chemical binding]; other site 324057001471 Mg2+ binding site [ion binding]; other site 324057001472 G-X-G motif; other site 324057001473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057001474 Response regulator receiver domain; Region: Response_reg; pfam00072 324057001475 active site 324057001476 phosphorylation site [posttranslational modification] 324057001477 intermolecular recognition site; other site 324057001478 dimerization interface [polypeptide binding]; other site 324057001479 Response regulator receiver domain; Region: Response_reg; pfam00072 324057001480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057001481 active site 324057001482 phosphorylation site [posttranslational modification] 324057001483 intermolecular recognition site; other site 324057001484 dimerization interface [polypeptide binding]; other site 324057001485 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 324057001486 putative binding surface; other site 324057001487 active site 324057001488 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057001489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057001490 active site 324057001491 phosphorylation site [posttranslational modification] 324057001492 intermolecular recognition site; other site 324057001493 dimerization interface [polypeptide binding]; other site 324057001494 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057001495 DNA binding site [nucleotide binding] 324057001496 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057001497 metal binding site [ion binding]; metal-binding site 324057001498 active site 324057001499 I-site; other site 324057001500 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 324057001501 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 324057001502 Catalytic domain of Protein Kinases; Region: PKc; cd00180 324057001503 active site 324057001504 ATP binding site [chemical binding]; other site 324057001505 substrate binding site [chemical binding]; other site 324057001506 activation loop (A-loop); other site 324057001507 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 324057001508 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 324057001509 E-class dimer interface [polypeptide binding]; other site 324057001510 P-class dimer interface [polypeptide binding]; other site 324057001511 active site 324057001512 Cu2+ binding site [ion binding]; other site 324057001513 Zn2+ binding site [ion binding]; other site 324057001514 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 324057001515 nudix motif; other site 324057001516 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 324057001517 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 324057001518 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 324057001519 SpoOM protein; Region: Spo0M; pfam07070 324057001520 Predicted membrane protein [Function unknown]; Region: COG4129 324057001521 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 324057001522 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 324057001523 Uncharacterized conserved protein [Function unknown]; Region: COG0398 324057001524 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 324057001525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057001526 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057001527 putative substrate translocation pore; other site 324057001528 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 324057001529 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 324057001530 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324057001531 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057001532 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057001533 active site 324057001534 catalytic tetrad [active] 324057001535 threonine dehydratase; Validated; Region: PRK08639 324057001536 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 324057001537 tetramer interface [polypeptide binding]; other site 324057001538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057001539 catalytic residue [active] 324057001540 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 324057001541 putative Ile/Val binding site [chemical binding]; other site 324057001542 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057001543 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057001544 DNA binding site [nucleotide binding] 324057001545 domain linker motif; other site 324057001546 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057001547 dimerization interface [polypeptide binding]; other site 324057001548 ligand binding site [chemical binding]; other site 324057001549 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057001550 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057001551 DNA binding site [nucleotide binding] 324057001552 domain linker motif; other site 324057001553 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057001554 ligand binding site [chemical binding]; other site 324057001555 dimerization interface [polypeptide binding]; other site 324057001556 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 324057001557 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057001558 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057001559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057001560 dimer interface [polypeptide binding]; other site 324057001561 conserved gate region; other site 324057001562 putative PBP binding loops; other site 324057001563 ABC-ATPase subunit interface; other site 324057001564 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057001565 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057001566 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057001567 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324057001568 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057001569 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 324057001570 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 324057001571 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 324057001572 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 324057001573 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 324057001574 oxidoreductase; Provisional; Region: PRK06196 324057001575 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 324057001576 putative NAD(P) binding site [chemical binding]; other site 324057001577 active site 324057001578 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 324057001579 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057001580 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001581 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 324057001582 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057001583 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057001584 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001585 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 324057001586 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 324057001587 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 324057001588 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 324057001589 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 324057001590 Ligand binding site [chemical binding]; other site 324057001591 Electron transfer flavoprotein domain; Region: ETF; pfam01012 324057001592 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 324057001593 4Fe-4S binding domain; Region: Fer4; cl02805 324057001594 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 324057001595 Cysteine-rich domain; Region: CCG; pfam02754 324057001596 Cysteine-rich domain; Region: CCG; pfam02754 324057001597 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 324057001598 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 324057001599 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 324057001600 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 324057001601 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 324057001602 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 324057001603 substrate binding site [chemical binding]; other site 324057001604 oxyanion hole (OAH) forming residues; other site 324057001605 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 324057001606 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 324057001607 dimer interface [polypeptide binding]; other site 324057001608 active site 324057001609 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 324057001610 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 324057001611 active site 324057001612 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 324057001613 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 324057001614 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 324057001615 acyl-activating enzyme (AAE) consensus motif; other site 324057001616 putative AMP binding site [chemical binding]; other site 324057001617 putative active site [active] 324057001618 putative CoA binding site [chemical binding]; other site 324057001619 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 324057001620 CoenzymeA binding site [chemical binding]; other site 324057001621 subunit interaction site [polypeptide binding]; other site 324057001622 PHB binding site; other site 324057001623 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057001624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057001625 active site 324057001626 phosphorylation site [posttranslational modification] 324057001627 intermolecular recognition site; other site 324057001628 dimerization interface [polypeptide binding]; other site 324057001629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057001630 DNA binding site [nucleotide binding] 324057001631 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057001632 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057001633 dimerization interface [polypeptide binding]; other site 324057001634 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057001635 dimer interface [polypeptide binding]; other site 324057001636 phosphorylation site [posttranslational modification] 324057001637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057001638 ATP binding site [chemical binding]; other site 324057001639 Mg2+ binding site [ion binding]; other site 324057001640 G-X-G motif; other site 324057001641 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 324057001642 Moco binding site; other site 324057001643 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 324057001644 metal coordination site [ion binding]; other site 324057001645 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 324057001646 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324057001647 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057001648 non-specific DNA binding site [nucleotide binding]; other site 324057001649 salt bridge; other site 324057001650 sequence-specific DNA binding site [nucleotide binding]; other site 324057001651 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 324057001652 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 324057001653 active site residue [active] 324057001654 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 324057001655 active site residue [active] 324057001656 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 324057001657 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 324057001658 P-loop; other site 324057001659 Magnesium ion binding site [ion binding]; other site 324057001660 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 324057001661 Magnesium ion binding site [ion binding]; other site 324057001662 Superfamily II helicase, archaea-specific [General function prediction only]; Region: COG1202 324057001663 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 324057001664 Cupin domain; Region: Cupin_2; pfam07883 324057001665 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057001666 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001667 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001668 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 324057001669 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 324057001670 putative active site [active] 324057001671 putative FMN binding site [chemical binding]; other site 324057001672 putative substrate binding site [chemical binding]; other site 324057001673 putative catalytic residue [active] 324057001674 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 324057001675 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 324057001676 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 324057001677 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057001678 active site 324057001679 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 324057001680 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 324057001681 active site 324057001682 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 324057001683 aromatic chitin/cellulose binding site residues [chemical binding]; other site 324057001684 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 324057001685 aromatic chitin/cellulose binding site residues [chemical binding]; other site 324057001686 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057001687 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057001688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057001689 dimer interface [polypeptide binding]; other site 324057001690 conserved gate region; other site 324057001691 putative PBP binding loops; other site 324057001692 ABC-ATPase subunit interface; other site 324057001693 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057001694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057001695 dimer interface [polypeptide binding]; other site 324057001696 conserved gate region; other site 324057001697 ABC-ATPase subunit interface; other site 324057001698 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 324057001699 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057001700 DNA-binding site [nucleotide binding]; DNA binding site 324057001701 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057001702 dimerization interface [polypeptide binding]; other site 324057001703 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057001704 ligand binding site [chemical binding]; other site 324057001705 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 324057001706 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 324057001707 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 324057001708 YCII-related domain; Region: YCII; cl00999 324057001709 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 324057001710 Cupin domain; Region: Cupin_2; cl17218 324057001711 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057001712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001713 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 324057001714 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 324057001715 Amidase; Region: Amidase; cl11426 324057001716 S-layer homology domain; Region: SLH; pfam00395 324057001717 S-layer homology domain; Region: SLH; pfam00395 324057001718 S-layer homology domain; Region: SLH; pfam00395 324057001719 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 324057001720 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057001721 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057001722 DNA binding residues [nucleotide binding] 324057001723 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 324057001724 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057001725 putative active site [active] 324057001726 putative metal binding site [ion binding]; other site 324057001727 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 324057001728 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057001729 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001730 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 324057001731 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057001732 dimerization interface [polypeptide binding]; other site 324057001733 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057001734 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057001735 dimer interface [polypeptide binding]; other site 324057001736 putative CheW interface [polypeptide binding]; other site 324057001737 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 324057001738 S-layer homology domain; Region: SLH; pfam00395 324057001739 S-layer homology domain; Region: SLH; pfam00395 324057001740 S-layer homology domain; Region: SLH; pfam00395 324057001741 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057001742 Interdomain contacts; other site 324057001743 Cytokine receptor motif; other site 324057001744 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057001745 Interdomain contacts; other site 324057001746 Cytokine receptor motif; other site 324057001747 AAA ATPase domain; Region: AAA_16; pfam13191 324057001748 AAA domain; Region: AAA_22; pfam13401 324057001749 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057001750 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057001751 dimerization interface [polypeptide binding]; other site 324057001752 DNA binding residues [nucleotide binding] 324057001753 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 324057001754 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 324057001755 Mg++ binding site [ion binding]; other site 324057001756 putative catalytic motif [active] 324057001757 substrate binding site [chemical binding]; other site 324057001758 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324057001759 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 324057001760 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 324057001761 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 324057001762 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057001763 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 324057001764 active site 324057001765 metal binding site [ion binding]; metal-binding site 324057001766 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 324057001767 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 324057001768 EamA-like transporter family; Region: EamA; pfam00892 324057001769 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 324057001770 EamA-like transporter family; Region: EamA; pfam00892 324057001771 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 324057001772 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057001773 DNA-binding site [nucleotide binding]; DNA binding site 324057001774 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057001775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057001776 homodimer interface [polypeptide binding]; other site 324057001777 catalytic residue [active] 324057001778 Cupin domain; Region: Cupin_2; cl17218 324057001779 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057001780 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057001781 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 324057001782 Sulfatase; Region: Sulfatase; pfam00884 324057001783 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 324057001784 Mechanosensitive ion channel; Region: MS_channel; pfam00924 324057001785 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 324057001786 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 324057001787 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 324057001788 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 324057001789 metal binding site [ion binding]; metal-binding site 324057001790 substrate binding pocket [chemical binding]; other site 324057001791 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 324057001792 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 324057001793 substrate binding pocket [chemical binding]; other site 324057001794 Predicted transcriptional regulators [Transcription]; Region: COG1733 324057001795 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 324057001796 Predicted transcriptional regulator [Transcription]; Region: COG2378 324057001797 HTH domain; Region: HTH_11; pfam08279 324057001798 WYL domain; Region: WYL; pfam13280 324057001799 DinB family; Region: DinB; cl17821 324057001800 DinB superfamily; Region: DinB_2; pfam12867 324057001801 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 324057001802 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 324057001803 putative NAD(P) binding site [chemical binding]; other site 324057001804 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 324057001805 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 324057001806 putative ligand binding site [chemical binding]; other site 324057001807 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 324057001808 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 324057001809 TM-ABC transporter signature motif; other site 324057001810 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 324057001811 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 324057001812 TM-ABC transporter signature motif; other site 324057001813 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 324057001814 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 324057001815 Walker A/P-loop; other site 324057001816 ATP binding site [chemical binding]; other site 324057001817 Q-loop/lid; other site 324057001818 ABC transporter signature motif; other site 324057001819 Walker B; other site 324057001820 D-loop; other site 324057001821 H-loop/switch region; other site 324057001822 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 324057001823 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 324057001824 Walker A/P-loop; other site 324057001825 ATP binding site [chemical binding]; other site 324057001826 Q-loop/lid; other site 324057001827 ABC transporter signature motif; other site 324057001828 Walker B; other site 324057001829 D-loop; other site 324057001830 H-loop/switch region; other site 324057001831 Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102 324057001832 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_IV; cd01994 324057001833 Ligand Binding Site [chemical binding]; other site 324057001834 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057001835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057001836 dimer interface [polypeptide binding]; other site 324057001837 conserved gate region; other site 324057001838 putative PBP binding loops; other site 324057001839 ABC-ATPase subunit interface; other site 324057001840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057001841 putative PBP binding loops; other site 324057001842 dimer interface [polypeptide binding]; other site 324057001843 ABC-ATPase subunit interface; other site 324057001844 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057001845 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057001846 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 324057001847 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057001848 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057001849 DNA binding site [nucleotide binding] 324057001850 domain linker motif; other site 324057001851 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057001852 dimerization interface [polypeptide binding]; other site 324057001853 ligand binding site [chemical binding]; other site 324057001854 YcxB-like protein; Region: YcxB; pfam14317 324057001855 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 324057001856 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 324057001857 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 324057001858 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057001859 Walker A/P-loop; other site 324057001860 ATP binding site [chemical binding]; other site 324057001861 Q-loop/lid; other site 324057001862 ABC transporter signature motif; other site 324057001863 Walker B; other site 324057001864 D-loop; other site 324057001865 H-loop/switch region; other site 324057001866 ABC transporter; Region: ABC_tran_2; pfam12848 324057001867 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324057001868 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 324057001869 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057001870 MarR family; Region: MarR; pfam01047 324057001871 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 324057001872 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 324057001873 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 324057001874 DXD motif; other site 324057001875 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 324057001876 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 324057001877 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 324057001878 Prephenate dehydratase; Region: PDT; pfam00800 324057001879 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 324057001880 putative L-Phe binding site [chemical binding]; other site 324057001881 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 324057001882 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057001883 putative DNA binding site [nucleotide binding]; other site 324057001884 putative Zn2+ binding site [ion binding]; other site 324057001885 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 324057001886 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 324057001887 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 324057001888 Sulfatase; Region: Sulfatase; cl17466 324057001889 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 324057001890 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 324057001891 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 324057001892 TrkA-C domain; Region: TrkA_C; pfam02080 324057001893 HPP family; Region: HPP; pfam04982 324057001894 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057001895 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057001896 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057001897 dimerization interface [polypeptide binding]; other site 324057001898 short chain dehydrogenase; Provisional; Region: PRK06500 324057001899 classical (c) SDRs; Region: SDR_c; cd05233 324057001900 NAD(P) binding site [chemical binding]; other site 324057001901 active site 324057001902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057001903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057001904 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057001905 MarR family; Region: MarR_2; pfam12802 324057001906 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 324057001907 dimer interface [polypeptide binding]; other site 324057001908 S-layer homology domain; Region: SLH; pfam00395 324057001909 S-layer homology domain; Region: SLH; pfam00395 324057001910 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 324057001911 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 324057001912 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 324057001913 trimer interface [polypeptide binding]; other site 324057001914 active site 324057001915 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 324057001916 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057001917 FeS/SAM binding site; other site 324057001918 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 324057001919 short chain dehydrogenase; Provisional; Region: PRK12747 324057001920 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 324057001921 NADP binding site [chemical binding]; other site 324057001922 homodimer interface [polypeptide binding]; other site 324057001923 active site 324057001924 substrate binding site [chemical binding]; other site 324057001925 Predicted acyl esterases [General function prediction only]; Region: COG2936 324057001926 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 324057001927 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 324057001928 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 324057001929 dimer interface [polypeptide binding]; other site 324057001930 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 324057001931 active site 324057001932 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 324057001933 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 324057001934 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 324057001935 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057001936 metal binding site [ion binding]; metal-binding site 324057001937 active site 324057001938 I-site; other site 324057001939 ApbE family; Region: ApbE; pfam02424 324057001940 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 324057001941 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057001942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057001943 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057001944 dimerization interface [polypeptide binding]; other site 324057001945 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 324057001946 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 324057001947 GDP-binding site [chemical binding]; other site 324057001948 ACT binding site; other site 324057001949 IMP binding site; other site 324057001950 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 324057001951 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 324057001952 EamA-like transporter family; Region: EamA; pfam00892 324057001953 EamA-like transporter family; Region: EamA; pfam00892 324057001954 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 324057001955 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057001956 Zn2+ binding site [ion binding]; other site 324057001957 Mg2+ binding site [ion binding]; other site 324057001958 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057001959 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 324057001960 sugar binding site [chemical binding]; other site 324057001961 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057001962 putative metal binding site [ion binding]; other site 324057001963 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057001964 sugar binding site [chemical binding]; other site 324057001965 CARDB; Region: CARDB; pfam07705 324057001966 CARDB; Region: CARDB; pfam07705 324057001967 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057001968 putative metal binding site [ion binding]; other site 324057001969 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 324057001970 glutamate racemase; Provisional; Region: PRK00865 324057001971 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 324057001972 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 324057001973 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 324057001974 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 324057001975 hypothetical protein; Validated; Region: PRK00029 324057001976 Uncharacterized conserved protein [Function unknown]; Region: COG0397 324057001977 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057001978 non-specific DNA binding site [nucleotide binding]; other site 324057001979 salt bridge; other site 324057001980 sequence-specific DNA binding site [nucleotide binding]; other site 324057001981 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 324057001982 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 324057001983 putative hydrophobic ligand binding site [chemical binding]; other site 324057001984 Chromate transporter; Region: Chromate_transp; pfam02417 324057001985 Chromate transporter; Region: Chromate_transp; pfam02417 324057001986 MarR family; Region: MarR_2; pfam12802 324057001987 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324057001988 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 324057001989 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 324057001990 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 324057001991 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 324057001992 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 324057001993 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057001994 Walker A/P-loop; other site 324057001995 ATP binding site [chemical binding]; other site 324057001996 Q-loop/lid; other site 324057001997 ABC transporter signature motif; other site 324057001998 Walker B; other site 324057001999 D-loop; other site 324057002000 H-loop/switch region; other site 324057002001 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 324057002002 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 324057002003 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 324057002004 nudix motif; other site 324057002005 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 324057002006 catalytic residues [active] 324057002007 dimer interface [polypeptide binding]; other site 324057002008 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 324057002009 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 324057002010 active site 324057002011 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 324057002012 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 324057002013 conserved cys residue [active] 324057002014 Helix-turn-helix domain; Region: HTH_18; pfam12833 324057002015 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 324057002017 Predicted transcriptional regulators [Transcription]; Region: COG1695 324057002018 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 324057002019 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 324057002020 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057002021 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057002022 active site 324057002023 catalytic tetrad [active] 324057002024 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 324057002025 Phosphotransferase enzyme family; Region: APH; pfam01636 324057002026 active site 324057002027 substrate binding site [chemical binding]; other site 324057002028 ATP binding site [chemical binding]; other site 324057002029 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 324057002030 transcriptional regulator NarL; Provisional; Region: PRK10651 324057002031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002032 active site 324057002033 phosphorylation site [posttranslational modification] 324057002034 intermolecular recognition site; other site 324057002035 dimerization interface [polypeptide binding]; other site 324057002036 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057002037 DNA binding residues [nucleotide binding] 324057002038 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057002039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002040 ATP binding site [chemical binding]; other site 324057002041 Mg2+ binding site [ion binding]; other site 324057002042 G-X-G motif; other site 324057002043 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057002044 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057002045 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057002046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002047 dimer interface [polypeptide binding]; other site 324057002048 conserved gate region; other site 324057002049 putative PBP binding loops; other site 324057002050 ABC-ATPase subunit interface; other site 324057002051 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057002052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002053 dimer interface [polypeptide binding]; other site 324057002054 conserved gate region; other site 324057002055 putative PBP binding loops; other site 324057002056 ABC-ATPase subunit interface; other site 324057002057 Sulfatase; Region: Sulfatase; cl17466 324057002058 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 324057002059 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 324057002060 putative acetyltransferase; Provisional; Region: PRK03624 324057002061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057002062 Coenzyme A binding pocket [chemical binding]; other site 324057002063 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057002064 Coenzyme A binding pocket [chemical binding]; other site 324057002065 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057002066 active site 324057002067 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057002068 catalytic tetrad [active] 324057002069 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057002070 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057002071 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057002072 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057002073 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002075 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002076 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 324057002077 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057002078 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 324057002079 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057002080 intersubunit interface [polypeptide binding]; other site 324057002081 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002082 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002083 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002084 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057002085 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057002086 intersubunit interface [polypeptide binding]; other site 324057002087 Predicted transcriptional regulator [Transcription]; Region: COG2378 324057002088 WYL domain; Region: WYL; pfam13280 324057002089 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 324057002090 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 324057002091 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 324057002092 putative ligand binding site [chemical binding]; other site 324057002093 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 324057002094 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 324057002095 Walker A/P-loop; other site 324057002096 ATP binding site [chemical binding]; other site 324057002097 Q-loop/lid; other site 324057002098 ABC transporter signature motif; other site 324057002099 Walker B; other site 324057002100 D-loop; other site 324057002101 H-loop/switch region; other site 324057002102 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 324057002103 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 324057002104 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 324057002105 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 324057002106 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 324057002107 TM-ABC transporter signature motif; other site 324057002108 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 324057002109 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057002110 ligand binding site [chemical binding]; other site 324057002111 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057002112 Cache domain; Region: Cache_1; pfam02743 324057002113 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057002114 dimerization interface [polypeptide binding]; other site 324057002115 Histidine kinase; Region: His_kinase; pfam06580 324057002116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002117 ATP binding site [chemical binding]; other site 324057002118 Mg2+ binding site [ion binding]; other site 324057002119 G-X-G motif; other site 324057002120 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057002121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002122 active site 324057002123 phosphorylation site [posttranslational modification] 324057002124 intermolecular recognition site; other site 324057002125 dimerization interface [polypeptide binding]; other site 324057002126 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002127 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057002128 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057002129 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057002130 dimerization interface [polypeptide binding]; other site 324057002131 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 324057002132 active site residue [active] 324057002133 Protein of unknown function (DUF975); Region: DUF975; pfam06161 324057002134 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 324057002135 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 324057002136 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 324057002137 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057002138 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057002139 dimerization interface [polypeptide binding]; other site 324057002140 Histidine kinase; Region: His_kinase; pfam06580 324057002141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002142 ATP binding site [chemical binding]; other site 324057002143 Mg2+ binding site [ion binding]; other site 324057002144 G-X-G motif; other site 324057002145 Response regulator receiver domain; Region: Response_reg; pfam00072 324057002146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002147 active site 324057002148 phosphorylation site [posttranslational modification] 324057002149 intermolecular recognition site; other site 324057002150 dimerization interface [polypeptide binding]; other site 324057002151 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057002152 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002153 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002154 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057002155 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057002156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002157 dimer interface [polypeptide binding]; other site 324057002158 conserved gate region; other site 324057002159 putative PBP binding loops; other site 324057002160 ABC-ATPase subunit interface; other site 324057002161 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057002162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002163 dimer interface [polypeptide binding]; other site 324057002164 conserved gate region; other site 324057002165 ABC-ATPase subunit interface; other site 324057002166 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057002167 Interdomain contacts; other site 324057002168 Cytokine receptor motif; other site 324057002169 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 324057002170 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 324057002171 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 324057002172 S-layer homology domain; Region: SLH; pfam00395 324057002173 S-layer homology domain; Region: SLH; pfam00395 324057002174 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057002175 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 324057002176 Metal-binding active site; metal-binding site 324057002177 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 324057002178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057002179 DNA-binding site [nucleotide binding]; DNA binding site 324057002180 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057002181 dimerization interface [polypeptide binding]; other site 324057002182 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057002183 ligand binding site [chemical binding]; other site 324057002184 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057002185 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057002186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002187 dimer interface [polypeptide binding]; other site 324057002188 conserved gate region; other site 324057002189 putative PBP binding loops; other site 324057002190 ABC-ATPase subunit interface; other site 324057002191 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057002192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002193 dimer interface [polypeptide binding]; other site 324057002194 conserved gate region; other site 324057002195 putative PBP binding loops; other site 324057002196 ABC-ATPase subunit interface; other site 324057002197 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 324057002198 active site 324057002199 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057002200 Transcription factor Tfb2; Region: Tfb2; cl04289 324057002201 Response regulator receiver domain; Region: Response_reg; pfam00072 324057002202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002203 active site 324057002204 phosphorylation site [posttranslational modification] 324057002205 intermolecular recognition site; other site 324057002206 dimerization interface [polypeptide binding]; other site 324057002207 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002209 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057002210 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057002211 dimerization interface [polypeptide binding]; other site 324057002212 Histidine kinase; Region: His_kinase; pfam06580 324057002213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002214 ATP binding site [chemical binding]; other site 324057002215 Mg2+ binding site [ion binding]; other site 324057002216 G-X-G motif; other site 324057002217 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057002218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002219 dimer interface [polypeptide binding]; other site 324057002220 conserved gate region; other site 324057002221 ABC-ATPase subunit interface; other site 324057002222 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057002223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002224 dimer interface [polypeptide binding]; other site 324057002225 conserved gate region; other site 324057002226 putative PBP binding loops; other site 324057002227 ABC-ATPase subunit interface; other site 324057002228 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 324057002229 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057002230 putative ligand binding residues [chemical binding]; other site 324057002231 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 324057002232 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057002233 ABC-ATPase subunit interface; other site 324057002234 dimer interface [polypeptide binding]; other site 324057002235 putative PBP binding regions; other site 324057002236 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 324057002237 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057002238 ABC-ATPase subunit interface; other site 324057002239 dimer interface [polypeptide binding]; other site 324057002240 putative PBP binding regions; other site 324057002241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002242 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002243 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002244 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 324057002245 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057002246 intersubunit interface [polypeptide binding]; other site 324057002247 Protein of unknown function (DUF975); Region: DUF975; cl10504 324057002248 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 324057002249 Ca2+ binding site [ion binding]; other site 324057002250 VCBS repeat; Region: VCBS_repeat; TIGR01965 324057002251 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 324057002252 Ca2+ binding site [ion binding]; other site 324057002253 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 324057002254 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 324057002255 S-layer homology domain; Region: SLH; pfam00395 324057002256 S-layer homology domain; Region: SLH; pfam00395 324057002257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057002258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057002259 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324057002260 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057002261 Walker A/P-loop; other site 324057002262 ATP binding site [chemical binding]; other site 324057002263 Q-loop/lid; other site 324057002264 ABC transporter signature motif; other site 324057002265 Walker B; other site 324057002266 D-loop; other site 324057002267 H-loop/switch region; other site 324057002268 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 324057002269 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 324057002270 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 324057002271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057002272 Coenzyme A binding pocket [chemical binding]; other site 324057002273 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057002274 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057002275 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 324057002276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057002277 putative substrate translocation pore; other site 324057002278 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057002279 putative active site [active] 324057002280 heme pocket [chemical binding]; other site 324057002281 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 324057002282 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057002283 metal binding site [ion binding]; metal-binding site 324057002284 active site 324057002285 I-site; other site 324057002286 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324057002287 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 324057002288 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002289 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002290 tyramine oxidase; Provisional; Region: tynA; PRK14696 324057002291 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057002292 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 324057002293 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 324057002294 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 324057002295 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057002296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057002297 Coenzyme A binding pocket [chemical binding]; other site 324057002298 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 324057002299 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 324057002300 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057002301 Zn2+ binding site [ion binding]; other site 324057002302 Mg2+ binding site [ion binding]; other site 324057002303 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 324057002304 active site 324057002305 metal binding site [ion binding]; metal-binding site 324057002306 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057002307 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324057002308 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 324057002309 Walker A/P-loop; other site 324057002310 ATP binding site [chemical binding]; other site 324057002311 Q-loop/lid; other site 324057002312 ABC transporter signature motif; other site 324057002313 Walker B; other site 324057002314 D-loop; other site 324057002315 H-loop/switch region; other site 324057002316 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 324057002317 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 324057002318 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 324057002319 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324057002320 Histidine kinase; Region: HisKA_3; pfam07730 324057002321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002322 ATP binding site [chemical binding]; other site 324057002323 Mg2+ binding site [ion binding]; other site 324057002324 G-X-G motif; other site 324057002325 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057002326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002327 active site 324057002328 phosphorylation site [posttranslational modification] 324057002329 intermolecular recognition site; other site 324057002330 dimerization interface [polypeptide binding]; other site 324057002331 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057002332 DNA binding residues [nucleotide binding] 324057002333 dimerization interface [polypeptide binding]; other site 324057002334 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057002335 Coenzyme A binding pocket [chemical binding]; other site 324057002336 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057002337 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057002338 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057002339 dimerization interface [polypeptide binding]; other site 324057002340 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 324057002341 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 324057002342 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 324057002343 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 324057002344 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 324057002345 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057002346 Histidine kinase; Region: His_kinase; pfam06580 324057002347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002348 ATP binding site [chemical binding]; other site 324057002349 Mg2+ binding site [ion binding]; other site 324057002350 G-X-G motif; other site 324057002351 Response regulator receiver domain; Region: Response_reg; pfam00072 324057002352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002353 active site 324057002354 phosphorylation site [posttranslational modification] 324057002355 intermolecular recognition site; other site 324057002356 dimerization interface [polypeptide binding]; other site 324057002357 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002358 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002359 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002360 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057002361 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057002362 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057002363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002364 dimer interface [polypeptide binding]; other site 324057002365 conserved gate region; other site 324057002366 putative PBP binding loops; other site 324057002367 ABC-ATPase subunit interface; other site 324057002368 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057002369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002370 dimer interface [polypeptide binding]; other site 324057002371 conserved gate region; other site 324057002372 putative PBP binding loops; other site 324057002373 ABC-ATPase subunit interface; other site 324057002374 ThiC-associated domain; Region: ThiC-associated; pfam13667 324057002375 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 324057002376 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 324057002377 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 324057002378 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 324057002379 putative NAD(P) binding site [chemical binding]; other site 324057002380 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 324057002381 generic binding surface I; other site 324057002382 generic binding surface II; other site 324057002383 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 324057002384 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 324057002385 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 324057002386 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 324057002387 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 324057002388 RDD family; Region: RDD; pfam06271 324057002389 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057002390 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057002391 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057002392 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057002393 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057002394 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057002395 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057002396 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057002397 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057002398 Histidine kinase; Region: His_kinase; pfam06580 324057002399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002400 ATP binding site [chemical binding]; other site 324057002401 Mg2+ binding site [ion binding]; other site 324057002402 G-X-G motif; other site 324057002403 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057002404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002405 active site 324057002406 phosphorylation site [posttranslational modification] 324057002407 intermolecular recognition site; other site 324057002408 dimerization interface [polypeptide binding]; other site 324057002409 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002410 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057002411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002412 dimer interface [polypeptide binding]; other site 324057002413 conserved gate region; other site 324057002414 ABC-ATPase subunit interface; other site 324057002415 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057002416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002417 dimer interface [polypeptide binding]; other site 324057002418 ABC-ATPase subunit interface; other site 324057002419 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057002420 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 324057002421 Right handed beta helix region; Region: Beta_helix; pfam13229 324057002422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057002423 TPR motif; other site 324057002424 binding surface 324057002425 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324057002426 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 324057002427 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 324057002428 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 324057002429 inhibitor binding site; inhibition site 324057002430 active site 324057002431 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 324057002432 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057002433 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002434 Helix-turn-helix domain; Region: HTH_18; pfam12833 324057002435 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002436 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 324057002437 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 324057002438 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 324057002439 active site 324057002440 putative catalytic site [active] 324057002441 DNA binding site [nucleotide binding] 324057002442 putative phosphate binding site [ion binding]; other site 324057002443 metal binding site A [ion binding]; metal-binding site 324057002444 AP binding site [nucleotide binding]; other site 324057002445 metal binding site B [ion binding]; metal-binding site 324057002446 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 324057002447 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 324057002448 active site 324057002449 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 324057002450 EamA-like transporter family; Region: EamA; pfam00892 324057002451 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324057002452 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 324057002453 Walker A/P-loop; other site 324057002454 ATP binding site [chemical binding]; other site 324057002455 Q-loop/lid; other site 324057002456 ABC transporter signature motif; other site 324057002457 Walker B; other site 324057002458 D-loop; other site 324057002459 H-loop/switch region; other site 324057002460 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057002461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002462 dimer interface [polypeptide binding]; other site 324057002463 conserved gate region; other site 324057002464 putative PBP binding loops; other site 324057002465 ABC-ATPase subunit interface; other site 324057002466 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 324057002467 active site 324057002468 catalytic site [active] 324057002469 substrate binding site [chemical binding]; other site 324057002470 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057002471 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057002472 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324057002473 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 324057002474 substrate binding pocket [chemical binding]; other site 324057002475 membrane-bound complex binding site; other site 324057002476 hinge residues; other site 324057002477 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 324057002478 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 324057002479 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 324057002480 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 324057002481 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 324057002482 active site 324057002483 intersubunit interface [polypeptide binding]; other site 324057002484 catalytic residue [active] 324057002485 fumarate hydratase; Reviewed; Region: fumC; PRK00485 324057002486 Class II fumarases; Region: Fumarase_classII; cd01362 324057002487 active site 324057002488 tetramer interface [polypeptide binding]; other site 324057002489 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 324057002490 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057002491 Walker A/P-loop; other site 324057002492 ATP binding site [chemical binding]; other site 324057002493 Q-loop/lid; other site 324057002494 ABC transporter signature motif; other site 324057002495 Walker B; other site 324057002496 D-loop; other site 324057002497 H-loop/switch region; other site 324057002498 ABC transporter; Region: ABC_tran_2; pfam12848 324057002499 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324057002500 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 324057002501 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 324057002502 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 324057002503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057002504 putative substrate translocation pore; other site 324057002505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057002506 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 324057002507 Ferritin-like domain; Region: Ferritin; pfam00210 324057002508 dimerization interface [polypeptide binding]; other site 324057002509 DPS ferroxidase diiron center [ion binding]; other site 324057002510 ion pore; other site 324057002511 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057002512 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057002513 DNA binding site [nucleotide binding] 324057002514 domain linker motif; other site 324057002515 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 324057002516 putative dimerization interface [polypeptide binding]; other site 324057002517 putative ligand binding site [chemical binding]; other site 324057002518 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 324057002519 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057002520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002521 dimer interface [polypeptide binding]; other site 324057002522 conserved gate region; other site 324057002523 ABC-ATPase subunit interface; other site 324057002524 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057002525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002526 dimer interface [polypeptide binding]; other site 324057002527 conserved gate region; other site 324057002528 putative PBP binding loops; other site 324057002529 ABC-ATPase subunit interface; other site 324057002530 trehalose synthase; Region: treS_nterm; TIGR02456 324057002531 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 324057002532 Ca binding site [ion binding]; other site 324057002533 active site 324057002534 catalytic site [active] 324057002535 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 324057002536 Response regulator receiver domain; Region: Response_reg; pfam00072 324057002537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002538 active site 324057002539 phosphorylation site [posttranslational modification] 324057002540 intermolecular recognition site; other site 324057002541 dimerization interface [polypeptide binding]; other site 324057002542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002543 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002544 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002545 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057002546 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057002547 dimerization interface [polypeptide binding]; other site 324057002548 Histidine kinase; Region: His_kinase; pfam06580 324057002549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002550 ATP binding site [chemical binding]; other site 324057002551 Mg2+ binding site [ion binding]; other site 324057002552 G-X-G motif; other site 324057002553 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057002554 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057002555 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057002556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002557 putative PBP binding loops; other site 324057002558 dimer interface [polypeptide binding]; other site 324057002559 ABC-ATPase subunit interface; other site 324057002560 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057002561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002562 dimer interface [polypeptide binding]; other site 324057002563 conserved gate region; other site 324057002564 putative PBP binding loops; other site 324057002565 ABC-ATPase subunit interface; other site 324057002566 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 324057002567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057002568 NAD(P) binding site [chemical binding]; other site 324057002569 active site 324057002570 galactonate dehydratase; Provisional; Region: PRK14017 324057002571 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 324057002572 putative active site pocket [active] 324057002573 putative metal binding site [ion binding]; other site 324057002574 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 324057002575 homodimer interface [polypeptide binding]; other site 324057002576 maltodextrin glucosidase; Provisional; Region: PRK10785 324057002577 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 324057002578 active site 324057002579 homodimer interface [polypeptide binding]; other site 324057002580 catalytic site [active] 324057002581 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 324057002582 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 324057002583 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 324057002584 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057002585 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057002586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002587 active site 324057002588 phosphorylation site [posttranslational modification] 324057002589 intermolecular recognition site; other site 324057002590 dimerization interface [polypeptide binding]; other site 324057002591 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057002592 DNA binding site [nucleotide binding] 324057002593 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057002594 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057002595 dimerization interface [polypeptide binding]; other site 324057002596 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057002597 dimer interface [polypeptide binding]; other site 324057002598 phosphorylation site [posttranslational modification] 324057002599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002600 ATP binding site [chemical binding]; other site 324057002601 Mg2+ binding site [ion binding]; other site 324057002602 G-X-G motif; other site 324057002603 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 324057002604 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 324057002605 active site 324057002606 tetramer interface; other site 324057002607 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 324057002608 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 324057002609 Walker A/P-loop; other site 324057002610 ATP binding site [chemical binding]; other site 324057002611 Q-loop/lid; other site 324057002612 ABC transporter signature motif; other site 324057002613 Walker B; other site 324057002614 D-loop; other site 324057002615 H-loop/switch region; other site 324057002616 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 324057002617 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 324057002618 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057002619 ABC-ATPase subunit interface; other site 324057002620 dimer interface [polypeptide binding]; other site 324057002621 putative PBP binding regions; other site 324057002622 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057002623 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057002624 intersubunit interface [polypeptide binding]; other site 324057002625 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 324057002626 heme-binding site [chemical binding]; other site 324057002627 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 324057002628 heme-binding site [chemical binding]; other site 324057002629 S-layer homology domain; Region: SLH; pfam00395 324057002630 S-layer homology domain; Region: SLH; pfam00395 324057002631 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 324057002632 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057002633 intersubunit interface [polypeptide binding]; other site 324057002634 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 324057002635 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057002636 ABC-ATPase subunit interface; other site 324057002637 dimer interface [polypeptide binding]; other site 324057002638 putative PBP binding regions; other site 324057002639 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 324057002640 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 324057002641 Walker A/P-loop; other site 324057002642 ATP binding site [chemical binding]; other site 324057002643 Q-loop/lid; other site 324057002644 ABC transporter signature motif; other site 324057002645 Walker B; other site 324057002646 D-loop; other site 324057002647 H-loop/switch region; other site 324057002648 Double zinc ribbon; Region: DZR; pfam12773 324057002649 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 324057002650 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 324057002651 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 324057002652 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 324057002653 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057002654 Coenzyme A binding pocket [chemical binding]; other site 324057002655 Protein of unknown function (DUF402); Region: DUF402; cl00979 324057002656 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 324057002657 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 324057002658 Catalytic site [active] 324057002659 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 324057002660 RNA/DNA hybrid binding site [nucleotide binding]; other site 324057002661 active site 324057002662 epoxyqueuosine reductase; Region: TIGR00276 324057002663 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 324057002664 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 324057002665 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 324057002666 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 324057002667 homodecamer interface [polypeptide binding]; other site 324057002668 GTP cyclohydrolase I; Provisional; Region: PLN03044 324057002669 active site 324057002670 putative catalytic site residues [active] 324057002671 zinc binding site [ion binding]; other site 324057002672 GTP-CH-I/GFRP interaction surface; other site 324057002673 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 324057002674 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 324057002675 nucleophilic elbow; other site 324057002676 catalytic triad; other site 324057002677 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 324057002678 Transcriptional regulator [Transcription]; Region: IclR; COG1414 324057002679 Bacterial transcriptional regulator; Region: IclR; pfam01614 324057002680 aconitate hydratase; Validated; Region: PRK09277 324057002681 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 324057002682 substrate binding site [chemical binding]; other site 324057002683 ligand binding site [chemical binding]; other site 324057002684 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 324057002685 substrate binding site [chemical binding]; other site 324057002686 Putative amidase domain; Region: Amidase_6; pfam12671 324057002687 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 324057002688 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 324057002689 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 324057002690 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 324057002691 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 324057002692 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 324057002693 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 324057002694 dimerization interface [polypeptide binding]; other site 324057002695 active site 324057002696 S-layer homology domain; Region: SLH; pfam00395 324057002697 S-layer homology domain; Region: SLH; pfam00395 324057002698 S-layer homology domain; Region: SLH; pfam00395 324057002699 Response regulator receiver domain; Region: Response_reg; pfam00072 324057002700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002701 active site 324057002702 phosphorylation site [posttranslational modification] 324057002703 intermolecular recognition site; other site 324057002704 dimerization interface [polypeptide binding]; other site 324057002705 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002707 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057002708 Histidine kinase; Region: His_kinase; pfam06580 324057002709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002710 ATP binding site [chemical binding]; other site 324057002711 Mg2+ binding site [ion binding]; other site 324057002712 G-X-G motif; other site 324057002713 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057002714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002715 dimer interface [polypeptide binding]; other site 324057002716 conserved gate region; other site 324057002717 ABC-ATPase subunit interface; other site 324057002718 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057002719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002720 dimer interface [polypeptide binding]; other site 324057002721 conserved gate region; other site 324057002722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057002723 ABC-ATPase subunit interface; other site 324057002724 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057002725 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057002726 S-layer homology domain; Region: SLH; pfam00395 324057002727 S-layer homology domain; Region: SLH; pfam00395 324057002728 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 324057002729 active site 324057002730 catalytic residues [active] 324057002731 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057002732 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057002733 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057002734 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 324057002735 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 324057002736 active site 324057002737 catalytic residues [active] 324057002738 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057002739 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057002740 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 324057002741 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057002742 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 324057002743 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057002744 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 324057002745 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057002746 sugar binding site [chemical binding]; other site 324057002747 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 324057002748 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324057002749 inhibitor-cofactor binding pocket; inhibition site 324057002750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057002751 catalytic residue [active] 324057002752 Transcriptional regulator [Transcription]; Region: LytR; COG1316 324057002753 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 324057002754 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 324057002755 Walker A/P-loop; other site 324057002756 ATP binding site [chemical binding]; other site 324057002757 Q-loop/lid; other site 324057002758 ABC transporter signature motif; other site 324057002759 Walker B; other site 324057002760 D-loop; other site 324057002761 H-loop/switch region; other site 324057002762 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 324057002763 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 324057002764 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 324057002765 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 324057002766 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 324057002767 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 324057002768 catalytic triad [active] 324057002769 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 324057002770 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 324057002771 NodB motif; other site 324057002772 active site 324057002773 catalytic site [active] 324057002774 Zn binding site [ion binding]; other site 324057002775 MoxR-like ATPases [General function prediction only]; Region: COG0714 324057002776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057002777 Walker A motif; other site 324057002778 ATP binding site [chemical binding]; other site 324057002779 Walker B motif; other site 324057002780 arginine finger; other site 324057002781 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 324057002782 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 324057002783 Protein of unknown function DUF58; Region: DUF58; pfam01882 324057002784 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 324057002785 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 324057002786 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 324057002787 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 324057002788 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 324057002789 NodB motif; other site 324057002790 active site 324057002791 catalytic site [active] 324057002792 metal binding site [ion binding]; metal-binding site 324057002793 GMP synthase; Reviewed; Region: guaA; PRK00074 324057002794 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 324057002795 AMP/PPi binding site [chemical binding]; other site 324057002796 candidate oxyanion hole; other site 324057002797 catalytic triad [active] 324057002798 potential glutamine specificity residues [chemical binding]; other site 324057002799 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 324057002800 ATP Binding subdomain [chemical binding]; other site 324057002801 Ligand Binding sites [chemical binding]; other site 324057002802 Dimerization subdomain; other site 324057002803 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057002804 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002805 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 324057002806 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 324057002807 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 324057002808 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 324057002809 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057002810 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057002811 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057002812 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057002813 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057002814 HAMP domain; Region: HAMP; pfam00672 324057002815 Histidine kinase; Region: His_kinase; pfam06580 324057002816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002817 ATP binding site [chemical binding]; other site 324057002818 Mg2+ binding site [ion binding]; other site 324057002819 G-X-G motif; other site 324057002820 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057002821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002822 active site 324057002823 phosphorylation site [posttranslational modification] 324057002824 intermolecular recognition site; other site 324057002825 dimerization interface [polypeptide binding]; other site 324057002826 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002827 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057002828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002829 dimer interface [polypeptide binding]; other site 324057002830 conserved gate region; other site 324057002831 ABC-ATPase subunit interface; other site 324057002832 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057002833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002834 dimer interface [polypeptide binding]; other site 324057002835 conserved gate region; other site 324057002836 ABC-ATPase subunit interface; other site 324057002837 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057002838 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057002839 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057002840 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 324057002841 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 324057002842 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 324057002843 S-layer homology domain; Region: SLH; pfam00395 324057002844 S-layer homology domain; Region: SLH; pfam00395 324057002845 S-layer homology domain; Region: SLH; pfam00395 324057002846 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057002847 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002848 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057002849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057002850 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 324057002851 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 324057002852 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 324057002853 NAD binding site [chemical binding]; other site 324057002854 sugar binding site [chemical binding]; other site 324057002855 divalent metal binding site [ion binding]; other site 324057002856 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324057002857 dimer interface [polypeptide binding]; other site 324057002858 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 324057002859 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 324057002860 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cl03838 324057002861 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 324057002862 methionine sulfoxide reductase B; Provisional; Region: PRK00222 324057002863 SelR domain; Region: SelR; pfam01641 324057002864 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 324057002865 putative FMN binding site [chemical binding]; other site 324057002866 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057002867 MarR family; Region: MarR; pfam01047 324057002868 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057002869 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057002870 dimerization interface [polypeptide binding]; other site 324057002871 putative DNA binding site [nucleotide binding]; other site 324057002872 putative Zn2+ binding site [ion binding]; other site 324057002873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057002874 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057002875 putative substrate translocation pore; other site 324057002876 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 324057002877 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057002878 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057002879 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 324057002880 active site 324057002881 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 324057002882 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 324057002883 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 324057002884 NAD binding site [chemical binding]; other site 324057002885 ATP-grasp domain; Region: ATP-grasp; pfam02222 324057002886 adenylosuccinate lyase; Provisional; Region: PRK07492 324057002887 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 324057002888 tetramer interface [polypeptide binding]; other site 324057002889 active site 324057002890 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 324057002891 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 324057002892 ATP binding site [chemical binding]; other site 324057002893 active site 324057002894 substrate binding site [chemical binding]; other site 324057002895 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 324057002896 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 324057002897 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 324057002898 putative active site [active] 324057002899 catalytic triad [active] 324057002900 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 324057002901 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 324057002902 dimerization interface [polypeptide binding]; other site 324057002903 ATP binding site [chemical binding]; other site 324057002904 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 324057002905 dimerization interface [polypeptide binding]; other site 324057002906 ATP binding site [chemical binding]; other site 324057002907 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 324057002908 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 324057002909 active site 324057002910 tetramer interface [polypeptide binding]; other site 324057002911 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057002912 active site 324057002913 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 324057002914 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 324057002915 dimerization interface [polypeptide binding]; other site 324057002916 putative ATP binding site [chemical binding]; other site 324057002917 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 324057002918 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 324057002919 active site 324057002920 substrate binding site [chemical binding]; other site 324057002921 cosubstrate binding site; other site 324057002922 catalytic site [active] 324057002923 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 324057002924 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 324057002925 purine monophosphate binding site [chemical binding]; other site 324057002926 dimer interface [polypeptide binding]; other site 324057002927 putative catalytic residues [active] 324057002928 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 324057002929 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 324057002930 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 324057002931 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 324057002932 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 324057002933 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 324057002934 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 324057002935 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324057002936 PGAP1-like protein; Region: PGAP1; pfam07819 324057002937 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 324057002938 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 324057002939 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 324057002940 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 324057002941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 324057002942 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 324057002943 putative active site [active] 324057002944 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 324057002945 putative active site [active] 324057002946 putative lipid kinase; Reviewed; Region: PRK13337 324057002947 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 324057002948 TRAM domain; Region: TRAM; cl01282 324057002949 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 324057002950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057002951 S-adenosylmethionine binding site [chemical binding]; other site 324057002952 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 324057002953 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057002954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057002955 dimer interface [polypeptide binding]; other site 324057002956 phosphorylation site [posttranslational modification] 324057002957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002958 ATP binding site [chemical binding]; other site 324057002959 Mg2+ binding site [ion binding]; other site 324057002960 G-X-G motif; other site 324057002961 Response regulator receiver domain; Region: Response_reg; pfam00072 324057002962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002963 active site 324057002964 phosphorylation site [posttranslational modification] 324057002965 intermolecular recognition site; other site 324057002966 dimerization interface [polypeptide binding]; other site 324057002967 Histidine kinase; Region: His_kinase; pfam06580 324057002968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057002969 ATP binding site [chemical binding]; other site 324057002970 Mg2+ binding site [ion binding]; other site 324057002971 G-X-G motif; other site 324057002972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057002973 Response regulator receiver domain; Region: Response_reg; pfam00072 324057002974 active site 324057002975 phosphorylation site [posttranslational modification] 324057002976 intermolecular recognition site; other site 324057002977 dimerization interface [polypeptide binding]; other site 324057002978 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 324057002979 Bacterial transcriptional activator domain; Region: BTAD; smart01043 324057002980 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 324057002981 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057002982 Interdomain contacts; other site 324057002983 Cytokine receptor motif; other site 324057002984 S-layer homology domain; Region: SLH; pfam00395 324057002985 S-layer homology domain; Region: SLH; pfam00395 324057002986 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057002987 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057002988 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057002989 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 324057002990 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 324057002991 inhibitor binding site; inhibition site 324057002992 active site 324057002993 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057002994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057002995 dimer interface [polypeptide binding]; other site 324057002996 conserved gate region; other site 324057002997 putative PBP binding loops; other site 324057002998 ABC-ATPase subunit interface; other site 324057002999 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057003000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003001 dimer interface [polypeptide binding]; other site 324057003002 conserved gate region; other site 324057003003 putative PBP binding loops; other site 324057003004 ABC-ATPase subunit interface; other site 324057003005 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057003006 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057003007 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057003008 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057003009 dimerization interface [polypeptide binding]; other site 324057003010 Histidine kinase; Region: His_kinase; pfam06580 324057003011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057003012 ATP binding site [chemical binding]; other site 324057003013 Mg2+ binding site [ion binding]; other site 324057003014 G-X-G motif; other site 324057003015 Response regulator receiver domain; Region: Response_reg; pfam00072 324057003016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057003017 active site 324057003018 phosphorylation site [posttranslational modification] 324057003019 intermolecular recognition site; other site 324057003020 dimerization interface [polypeptide binding]; other site 324057003021 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057003022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003023 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 324057003024 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 324057003025 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 324057003026 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 324057003027 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 324057003028 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 324057003029 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 324057003030 homodimer interface [polypeptide binding]; other site 324057003031 NADP binding site [chemical binding]; other site 324057003032 substrate binding site [chemical binding]; other site 324057003033 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 324057003034 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 324057003035 putative active site [active] 324057003036 putative metal binding site [ion binding]; other site 324057003037 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057003038 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324057003039 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 324057003040 Walker A/P-loop; other site 324057003041 ATP binding site [chemical binding]; other site 324057003042 Q-loop/lid; other site 324057003043 ABC transporter signature motif; other site 324057003044 Walker B; other site 324057003045 D-loop; other site 324057003046 H-loop/switch region; other site 324057003047 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057003048 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324057003049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057003050 Walker A/P-loop; other site 324057003051 ATP binding site [chemical binding]; other site 324057003052 Q-loop/lid; other site 324057003053 ABC transporter signature motif; other site 324057003054 Walker B; other site 324057003055 D-loop; other site 324057003056 H-loop/switch region; other site 324057003057 aminoglycoside resistance protein; Provisional; Region: PRK13746 324057003058 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 324057003059 active site 324057003060 NTP binding site [chemical binding]; other site 324057003061 metal binding triad [ion binding]; metal-binding site 324057003062 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 324057003063 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 324057003064 active site 324057003065 Response regulator receiver domain; Region: Response_reg; pfam00072 324057003066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057003067 active site 324057003068 phosphorylation site [posttranslational modification] 324057003069 intermolecular recognition site; other site 324057003070 dimerization interface [polypeptide binding]; other site 324057003071 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057003072 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003073 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057003074 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057003075 dimerization interface [polypeptide binding]; other site 324057003076 Histidine kinase; Region: His_kinase; pfam06580 324057003077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057003078 ATP binding site [chemical binding]; other site 324057003079 Mg2+ binding site [ion binding]; other site 324057003080 G-X-G motif; other site 324057003081 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057003082 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057003083 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057003084 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 324057003085 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057003086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003087 dimer interface [polypeptide binding]; other site 324057003088 conserved gate region; other site 324057003089 putative PBP binding loops; other site 324057003090 ABC-ATPase subunit interface; other site 324057003091 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057003092 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057003093 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324057003094 catalytic core [active] 324057003095 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 324057003096 Domain of unknown function DUF20; Region: UPF0118; pfam01594 324057003097 Spore germination protein; Region: Spore_permease; cl17796 324057003098 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057003099 Spore germination protein; Region: Spore_permease; cl17796 324057003100 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057003101 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057003102 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057003103 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057003104 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057003105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 324057003106 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 324057003107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057003108 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057003109 putative substrate translocation pore; other site 324057003110 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003111 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057003112 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003113 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 324057003114 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 324057003115 DNA binding residues [nucleotide binding] 324057003116 putative dimer interface [polypeptide binding]; other site 324057003117 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 324057003118 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 324057003119 catalytic residues [active] 324057003120 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 324057003121 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 324057003122 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 324057003123 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057003124 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 324057003125 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057003126 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057003127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003128 dimer interface [polypeptide binding]; other site 324057003129 conserved gate region; other site 324057003130 putative PBP binding loops; other site 324057003131 ABC-ATPase subunit interface; other site 324057003132 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057003133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003134 dimer interface [polypeptide binding]; other site 324057003135 conserved gate region; other site 324057003136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057003137 ABC-ATPase subunit interface; other site 324057003138 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057003139 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003140 Right handed beta helix region; Region: Beta_helix; pfam13229 324057003141 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 324057003142 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 324057003143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057003144 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057003145 putative substrate translocation pore; other site 324057003146 MarR family; Region: MarR; pfam01047 324057003147 histidyl-tRNA synthetase; Provisional; Region: PRK12420 324057003148 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 324057003149 dimer interface [polypeptide binding]; other site 324057003150 motif 1; other site 324057003151 active site 324057003152 motif 2; other site 324057003153 motif 3; other site 324057003154 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 324057003155 anticodon binding site; other site 324057003156 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324057003157 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057003158 non-specific DNA binding site [nucleotide binding]; other site 324057003159 salt bridge; other site 324057003160 sequence-specific DNA binding site [nucleotide binding]; other site 324057003161 tellurite resistance protein TehB; Provisional; Region: PRK11207 324057003162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057003163 S-adenosylmethionine binding site [chemical binding]; other site 324057003164 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 324057003165 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 324057003166 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 324057003167 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 324057003168 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 324057003169 dihydroorotase; Provisional; Region: PRK09237 324057003170 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324057003171 active site 324057003172 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 324057003173 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057003174 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057003175 catalytic residue [active] 324057003176 catalytic residue [active] 324057003177 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 324057003178 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 324057003179 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 324057003180 substrate binding site [chemical binding]; other site 324057003181 ATP binding site [chemical binding]; other site 324057003182 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 324057003183 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057003184 DNA-binding site [nucleotide binding]; DNA binding site 324057003185 UTRA domain; Region: UTRA; pfam07702 324057003186 Uncharacterized conserved protein [Function unknown]; Region: COG5646 324057003187 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 324057003188 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057003189 Coenzyme A binding pocket [chemical binding]; other site 324057003190 DinB superfamily; Region: DinB_2; pfam12867 324057003191 Response regulator receiver domain; Region: Response_reg; pfam00072 324057003192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057003193 active site 324057003194 phosphorylation site [posttranslational modification] 324057003195 intermolecular recognition site; other site 324057003196 dimerization interface [polypeptide binding]; other site 324057003197 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057003198 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003199 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057003200 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057003201 dimerization interface [polypeptide binding]; other site 324057003202 Histidine kinase; Region: His_kinase; pfam06580 324057003203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057003204 Mg2+ binding site [ion binding]; other site 324057003205 G-X-G motif; other site 324057003206 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057003207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003208 dimer interface [polypeptide binding]; other site 324057003209 conserved gate region; other site 324057003210 ABC-ATPase subunit interface; other site 324057003211 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057003212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003213 dimer interface [polypeptide binding]; other site 324057003214 conserved gate region; other site 324057003215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057003216 ABC-ATPase subunit interface; other site 324057003217 S-layer homology domain; Region: SLH; pfam00395 324057003218 S-layer homology domain; Region: SLH; pfam00395 324057003219 S-layer homology domain; Region: SLH; pfam00395 324057003220 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 324057003221 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 324057003222 active site 324057003223 catalytic residues [active] 324057003224 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057003225 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057003226 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 324057003227 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057003228 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057003229 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 324057003230 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 324057003231 active site 324057003232 active site 324057003233 catalytic residues [active] 324057003234 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057003235 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057003236 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057003237 dimerization interface [polypeptide binding]; other site 324057003238 Histidine kinase; Region: His_kinase; pfam06580 324057003239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057003240 ATP binding site [chemical binding]; other site 324057003241 Mg2+ binding site [ion binding]; other site 324057003242 G-X-G motif; other site 324057003243 Response regulator receiver domain; Region: Response_reg; pfam00072 324057003244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057003245 active site 324057003246 phosphorylation site [posttranslational modification] 324057003247 intermolecular recognition site; other site 324057003248 dimerization interface [polypeptide binding]; other site 324057003249 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003250 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057003251 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003252 PBP superfamily domain; Region: PBP_like_2; cl17296 324057003253 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057003254 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057003255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003256 dimer interface [polypeptide binding]; other site 324057003257 conserved gate region; other site 324057003258 ABC-ATPase subunit interface; other site 324057003259 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057003260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003261 dimer interface [polypeptide binding]; other site 324057003262 conserved gate region; other site 324057003263 putative PBP binding loops; other site 324057003264 ABC-ATPase subunit interface; other site 324057003265 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 324057003266 Sulfatase; Region: Sulfatase; cl17466 324057003267 Uncharacterized conserved protein [Function unknown]; Region: COG1262 324057003268 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 324057003269 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 324057003270 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057003271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003272 dimer interface [polypeptide binding]; other site 324057003273 conserved gate region; other site 324057003274 putative PBP binding loops; other site 324057003275 ABC-ATPase subunit interface; other site 324057003276 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057003277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003278 dimer interface [polypeptide binding]; other site 324057003279 conserved gate region; other site 324057003280 putative PBP binding loops; other site 324057003281 ABC-ATPase subunit interface; other site 324057003282 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057003283 putative metal binding site [ion binding]; other site 324057003284 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057003285 putative metal binding site [ion binding]; other site 324057003286 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 324057003287 Right handed beta helix region; Region: Beta_helix; pfam13229 324057003288 S-layer homology domain; Region: SLH; pfam00395 324057003289 S-layer homology domain; Region: SLH; pfam00395 324057003290 S-layer homology domain; Region: SLH; pfam00395 324057003291 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057003292 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057003293 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057003294 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057003295 dimerization interface [polypeptide binding]; other site 324057003296 Histidine kinase; Region: His_kinase; pfam06580 324057003297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057003298 ATP binding site [chemical binding]; other site 324057003299 Mg2+ binding site [ion binding]; other site 324057003300 G-X-G motif; other site 324057003301 Response regulator receiver domain; Region: Response_reg; pfam00072 324057003302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057003303 active site 324057003304 phosphorylation site [posttranslational modification] 324057003305 intermolecular recognition site; other site 324057003306 dimerization interface [polypeptide binding]; other site 324057003307 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057003308 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003309 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057003310 Spore germination protein; Region: Spore_permease; cl17796 324057003311 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057003312 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057003313 CAAX protease self-immunity; Region: Abi; pfam02517 324057003314 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 324057003315 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057003316 ligand binding site [chemical binding]; other site 324057003317 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057003318 dimerization interface [polypeptide binding]; other site 324057003319 Histidine kinase; Region: His_kinase; pfam06580 324057003320 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 324057003321 ATP binding site [chemical binding]; other site 324057003322 Mg2+ binding site [ion binding]; other site 324057003323 G-X-G motif; other site 324057003324 Response regulator receiver domain; Region: Response_reg; pfam00072 324057003325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057003326 active site 324057003327 phosphorylation site [posttranslational modification] 324057003328 intermolecular recognition site; other site 324057003329 dimerization interface [polypeptide binding]; other site 324057003330 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057003331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003332 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 324057003333 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 324057003334 putative ligand binding site [chemical binding]; other site 324057003335 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 324057003336 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 324057003337 putative ligand binding site [chemical binding]; other site 324057003338 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 324057003339 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 324057003340 Walker A/P-loop; other site 324057003341 ATP binding site [chemical binding]; other site 324057003342 Q-loop/lid; other site 324057003343 ABC transporter signature motif; other site 324057003344 Walker B; other site 324057003345 D-loop; other site 324057003346 H-loop/switch region; other site 324057003347 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 324057003348 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 324057003349 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 324057003350 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 324057003351 TM-ABC transporter signature motif; other site 324057003352 uracil transporter; Provisional; Region: PRK10720 324057003353 Putative Ig domain; Region: He_PIG; pfam05345 324057003354 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 324057003355 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 324057003356 S-layer homology domain; Region: SLH; pfam00395 324057003357 S-layer homology domain; Region: SLH; pfam00395 324057003358 hypothetical protein; Provisional; Region: PRK13660 324057003359 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057003360 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057003361 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057003362 SEC-C motif; Region: SEC-C; pfam02810 324057003363 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 324057003364 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 324057003365 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 324057003366 Protein of unknown function (DUF458); Region: DUF458; pfam04308 324057003367 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057003368 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 324057003369 active site 324057003370 metal binding site [ion binding]; metal-binding site 324057003371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057003372 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057003373 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057003374 dimer interface [polypeptide binding]; other site 324057003375 phosphorylation site [posttranslational modification] 324057003376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057003377 ATP binding site [chemical binding]; other site 324057003378 Mg2+ binding site [ion binding]; other site 324057003379 G-X-G motif; other site 324057003380 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 324057003381 hypothetical protein; Provisional; Region: PRK11479 324057003382 short chain dehydrogenase; Provisional; Region: PRK06701 324057003383 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 324057003384 NAD binding site [chemical binding]; other site 324057003385 metal binding site [ion binding]; metal-binding site 324057003386 active site 324057003387 Imelysin; Region: Peptidase_M75; pfam09375 324057003388 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 324057003389 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 324057003390 Iron permease FTR1 family; Region: FTR1; cl00475 324057003391 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 324057003392 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 324057003393 nucleophilic elbow; other site 324057003394 catalytic triad; other site 324057003395 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 324057003396 active site flap/lid [active] 324057003397 nucleophilic elbow; other site 324057003398 catalytic triad [active] 324057003399 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 324057003400 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 324057003401 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 324057003402 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 324057003403 active site 324057003404 dimer interface [polypeptide binding]; other site 324057003405 motif 1; other site 324057003406 motif 2; other site 324057003407 motif 3; other site 324057003408 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 324057003409 anticodon binding site; other site 324057003410 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 324057003411 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 324057003412 Cl binding site [ion binding]; other site 324057003413 oligomer interface [polypeptide binding]; other site 324057003414 Heat induced stress protein YflT; Region: YflT; pfam11181 324057003415 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 324057003416 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 324057003417 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057003418 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003419 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057003420 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003421 galactokinase; Provisional; Region: PRK05322 324057003422 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 324057003423 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 324057003424 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 324057003425 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 324057003426 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 324057003427 NAD binding site [chemical binding]; other site 324057003428 homodimer interface [polypeptide binding]; other site 324057003429 active site 324057003430 substrate binding site [chemical binding]; other site 324057003431 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 324057003432 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 324057003433 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 324057003434 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 324057003435 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 324057003436 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 324057003437 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 324057003438 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324057003439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057003440 S-adenosylmethionine binding site [chemical binding]; other site 324057003441 PAS fold; Region: PAS; pfam00989 324057003442 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 324057003443 putative active site [active] 324057003444 heme pocket [chemical binding]; other site 324057003445 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 324057003446 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057003447 metal binding site [ion binding]; metal-binding site 324057003448 active site 324057003449 I-site; other site 324057003450 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 324057003451 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057003452 Zn2+ binding site [ion binding]; other site 324057003453 Mg2+ binding site [ion binding]; other site 324057003454 Uncharacterized conserved protein [Function unknown]; Region: COG1284 324057003455 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324057003456 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 324057003457 thiamine monophosphate kinase; Provisional; Region: PRK05731 324057003458 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 324057003459 ATP binding site [chemical binding]; other site 324057003460 dimerization interface [polypeptide binding]; other site 324057003461 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 324057003462 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 324057003463 Glycoprotease family; Region: Peptidase_M22; pfam00814 324057003464 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 324057003465 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057003466 Coenzyme A binding pocket [chemical binding]; other site 324057003467 UGMP family protein; Validated; Region: PRK09604 324057003468 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 324057003469 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 324057003470 2-isopropylmalate synthase; Validated; Region: PRK00915 324057003471 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 324057003472 active site 324057003473 catalytic residues [active] 324057003474 metal binding site [ion binding]; metal-binding site 324057003475 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 324057003476 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057003477 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 324057003478 Walker A/P-loop; other site 324057003479 ATP binding site [chemical binding]; other site 324057003480 Q-loop/lid; other site 324057003481 ABC transporter signature motif; other site 324057003482 Walker B; other site 324057003483 D-loop; other site 324057003484 H-loop/switch region; other site 324057003485 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 324057003486 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 324057003487 substrate binding pocket [chemical binding]; other site 324057003488 substrate-Mg2+ binding site; other site 324057003489 aspartate-rich region 1; other site 324057003490 aspartate-rich region 2; other site 324057003491 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 324057003492 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324057003493 Histidine kinase; Region: HisKA_3; pfam07730 324057003494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057003495 ATP binding site [chemical binding]; other site 324057003496 Mg2+ binding site [ion binding]; other site 324057003497 G-X-G motif; other site 324057003498 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057003499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057003500 active site 324057003501 phosphorylation site [posttranslational modification] 324057003502 intermolecular recognition site; other site 324057003503 dimerization interface [polypeptide binding]; other site 324057003504 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057003505 DNA binding residues [nucleotide binding] 324057003506 dimerization interface [polypeptide binding]; other site 324057003507 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 324057003508 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324057003509 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324057003510 ABC transporter; Region: ABC_tran_2; pfam12848 324057003511 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324057003512 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 324057003513 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 324057003514 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 324057003515 trimer interface [polypeptide binding]; other site 324057003516 dimer interface [polypeptide binding]; other site 324057003517 putative active site [active] 324057003518 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 324057003519 MPT binding site; other site 324057003520 trimer interface [polypeptide binding]; other site 324057003521 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 324057003522 putative MPT binding site; other site 324057003523 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 324057003524 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 324057003525 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 324057003526 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 324057003527 ligand binding site; other site 324057003528 oligomer interface; other site 324057003529 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 324057003530 N-terminal domain interface [polypeptide binding]; other site 324057003531 sulfate 1 binding site; other site 324057003532 glycogen branching enzyme; Provisional; Region: PRK12313 324057003533 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 324057003534 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 324057003535 active site 324057003536 catalytic site [active] 324057003537 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 324057003538 glycogen synthase; Provisional; Region: glgA; PRK00654 324057003539 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 324057003540 ADP-binding pocket [chemical binding]; other site 324057003541 homodimer interface [polypeptide binding]; other site 324057003542 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 324057003543 homodimer interface [polypeptide binding]; other site 324057003544 maltodextrin glucosidase; Provisional; Region: PRK10785 324057003545 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 324057003546 active site 324057003547 homodimer interface [polypeptide binding]; other site 324057003548 catalytic site [active] 324057003549 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 324057003550 classical (c) SDRs; Region: SDR_c; cd05233 324057003551 NAD(P) binding site [chemical binding]; other site 324057003552 active site 324057003553 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 324057003554 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 324057003555 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 324057003556 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057003557 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057003558 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 324057003559 oligomerisation interface [polypeptide binding]; other site 324057003560 mobile loop; other site 324057003561 roof hairpin; other site 324057003562 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 324057003563 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 324057003564 ring oligomerisation interface [polypeptide binding]; other site 324057003565 ATP/Mg binding site [chemical binding]; other site 324057003566 stacking interactions; other site 324057003567 hinge regions; other site 324057003568 metal-dependent hydrolase; Provisional; Region: PRK13291 324057003569 DinB superfamily; Region: DinB_2; pfam12867 324057003570 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057003571 active site 324057003572 xanthine permease; Region: pbuX; TIGR03173 324057003573 hypothetical protein; Provisional; Region: PRK11281 324057003574 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324057003575 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 324057003576 substrate binding pocket [chemical binding]; other site 324057003577 membrane-bound complex binding site; other site 324057003578 hinge residues; other site 324057003579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003580 dimer interface [polypeptide binding]; other site 324057003581 conserved gate region; other site 324057003582 putative PBP binding loops; other site 324057003583 ABC-ATPase subunit interface; other site 324057003584 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 324057003585 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 324057003586 Walker A/P-loop; other site 324057003587 ATP binding site [chemical binding]; other site 324057003588 Q-loop/lid; other site 324057003589 ABC transporter signature motif; other site 324057003590 Walker B; other site 324057003591 D-loop; other site 324057003592 H-loop/switch region; other site 324057003593 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324057003594 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 324057003595 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 324057003596 dimer interface [polypeptide binding]; other site 324057003597 active site 324057003598 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 324057003599 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 324057003600 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 324057003601 GAF domain; Region: GAF_2; pfam13185 324057003602 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 324057003603 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 324057003604 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 324057003605 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 324057003606 Cache domain; Region: Cache_1; pfam02743 324057003607 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057003608 dimerization interface [polypeptide binding]; other site 324057003609 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 324057003610 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057003611 metal binding site [ion binding]; metal-binding site 324057003612 active site 324057003613 I-site; other site 324057003614 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 324057003615 Cupin domain; Region: Cupin_2; cl17218 324057003616 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057003617 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003618 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 324057003619 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 324057003620 domain interfaces; other site 324057003621 active site 324057003622 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 324057003623 Predicted membrane protein [Function unknown]; Region: COG1238 324057003624 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 324057003625 active site 324057003626 homodimer interface [polypeptide binding]; other site 324057003627 homotetramer interface [polypeptide binding]; other site 324057003628 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 324057003629 active site 324057003630 homodimer interface [polypeptide binding]; other site 324057003631 homotetramer interface [polypeptide binding]; other site 324057003632 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057003633 Interdomain contacts; other site 324057003634 S-layer homology domain; Region: SLH; pfam00395 324057003635 S-layer homology domain; Region: SLH; pfam00395 324057003636 S-layer homology domain; Region: SLH; pfam00395 324057003637 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 324057003638 alanine racemase; Reviewed; Region: alr; PRK00053 324057003639 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 324057003640 active site 324057003641 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 324057003642 dimer interface [polypeptide binding]; other site 324057003643 substrate binding site [chemical binding]; other site 324057003644 catalytic residues [active] 324057003645 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 324057003646 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 324057003647 HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; Region: HECTc; cl00077 324057003648 PemK-like protein; Region: PemK; pfam02452 324057003649 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 324057003650 AAA domain; Region: AAA_31; pfam13614 324057003651 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 324057003652 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 324057003653 Walker A motif; other site 324057003654 ATP binding site [chemical binding]; other site 324057003655 Walker B motif; other site 324057003656 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 324057003657 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 324057003658 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 324057003659 active site 324057003660 Uncharacterized conserved protein [Function unknown]; Region: COG3402 324057003661 Predicted membrane protein [Function unknown]; Region: COG3428 324057003662 Bacterial PH domain; Region: DUF304; pfam03703 324057003663 Bacterial PH domain; Region: DUF304; pfam03703 324057003664 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 324057003665 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 324057003666 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 324057003667 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 324057003668 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 324057003669 GatB domain; Region: GatB_Yqey; smart00845 324057003670 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 324057003671 MgtC family; Region: MgtC; pfam02308 324057003672 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 324057003673 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 324057003674 ferric uptake regulator; Provisional; Region: fur; PRK09462 324057003675 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 324057003676 metal binding site 2 [ion binding]; metal-binding site 324057003677 putative DNA binding helix; other site 324057003678 metal binding site 1 [ion binding]; metal-binding site 324057003679 dimer interface [polypeptide binding]; other site 324057003680 structural Zn2+ binding site [ion binding]; other site 324057003681 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057003682 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 324057003683 active site 324057003684 hypothetical protein; Provisional; Region: PRK02935 324057003685 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057003686 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057003687 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057003688 Spore germination protein; Region: Spore_permease; cl17796 324057003689 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 324057003690 PspC domain; Region: PspC; pfam04024 324057003691 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 324057003692 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324057003693 Histidine kinase; Region: HisKA_3; pfam07730 324057003694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057003695 ATP binding site [chemical binding]; other site 324057003696 Mg2+ binding site [ion binding]; other site 324057003697 G-X-G motif; other site 324057003698 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057003699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057003700 active site 324057003701 phosphorylation site [posttranslational modification] 324057003702 intermolecular recognition site; other site 324057003703 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057003704 DNA binding residues [nucleotide binding] 324057003705 dimerization interface [polypeptide binding]; other site 324057003706 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 324057003707 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 324057003708 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 324057003709 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 324057003710 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 324057003711 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 324057003712 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 324057003713 G1 box; other site 324057003714 putative GEF interaction site [polypeptide binding]; other site 324057003715 GTP/Mg2+ binding site [chemical binding]; other site 324057003716 Switch I region; other site 324057003717 G2 box; other site 324057003718 G3 box; other site 324057003719 Switch II region; other site 324057003720 G4 box; other site 324057003721 G5 box; other site 324057003722 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 324057003723 TM2 domain; Region: TM2; pfam05154 324057003724 TM2 domain; Region: TM2; pfam05154 324057003725 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057003726 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057003727 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057003728 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 324057003729 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057003730 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057003731 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 324057003732 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324057003733 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324057003734 active site 324057003735 Small, acid-soluble spore protein I; Region: SSPI; pfam14098 324057003736 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 324057003737 TrkA-N domain; Region: TrkA_N; pfam02254 324057003738 TrkA-C domain; Region: TrkA_C; pfam02080 324057003739 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 324057003740 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 324057003741 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 324057003742 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 324057003743 active site 324057003744 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 324057003745 Ca binding site [ion binding]; other site 324057003746 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 324057003747 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 324057003748 S-layer homology domain; Region: SLH; pfam00395 324057003749 S-layer homology domain; Region: SLH; pfam00395 324057003750 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 324057003751 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 324057003752 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 324057003753 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 324057003754 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 324057003755 S-layer homology domain; Region: SLH; pfam00395 324057003756 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 324057003757 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 324057003758 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 324057003759 active site 324057003760 DNA binding site [nucleotide binding] 324057003761 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 324057003762 DNA binding site [nucleotide binding] 324057003763 phage shock protein A; Region: phageshock_pspA; TIGR02977 324057003764 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 324057003765 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 324057003766 metal-binding site [ion binding] 324057003767 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324057003768 Soluble P-type ATPase [General function prediction only]; Region: COG4087 324057003769 Copper resistance protein D; Region: CopD; cl00563 324057003770 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057003771 dimerization interface [polypeptide binding]; other site 324057003772 putative DNA binding site [nucleotide binding]; other site 324057003773 putative Zn2+ binding site [ion binding]; other site 324057003774 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 324057003775 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 324057003776 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057003777 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 324057003778 dimer interface [polypeptide binding]; other site 324057003779 catalytic triad [active] 324057003780 peroxidatic and resolving cysteines [active] 324057003781 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057003782 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057003783 putative DNA binding site [nucleotide binding]; other site 324057003784 putative Zn2+ binding site [ion binding]; other site 324057003785 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057003786 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057003787 active site 324057003788 catalytic tetrad [active] 324057003789 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 324057003790 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003791 Helix-turn-helix domain; Region: HTH_18; pfam12833 324057003792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057003793 sugar efflux transporter; Region: 2A0120; TIGR00899 324057003794 putative substrate translocation pore; other site 324057003795 Predicted kinase [General function prediction only]; Region: COG0645 324057003796 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 324057003797 active site 324057003798 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 324057003799 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 324057003800 S-layer homology domain; Region: SLH; pfam00395 324057003801 S-layer homology domain; Region: SLH; pfam00395 324057003802 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057003803 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057003804 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 324057003805 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 324057003806 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057003807 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 324057003808 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057003809 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057003810 active site 324057003811 catalytic tetrad [active] 324057003812 Cupin domain; Region: Cupin_2; pfam07883 324057003813 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057003814 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003815 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 324057003816 EamA-like transporter family; Region: EamA; pfam00892 324057003817 EamA-like transporter family; Region: EamA; pfam00892 324057003818 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324057003819 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 324057003820 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324057003821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057003822 S-adenosylmethionine binding site [chemical binding]; other site 324057003823 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 324057003824 active site 324057003825 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 324057003826 Response regulator receiver domain; Region: Response_reg; pfam00072 324057003827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057003828 active site 324057003829 phosphorylation site [posttranslational modification] 324057003830 intermolecular recognition site; other site 324057003831 dimerization interface [polypeptide binding]; other site 324057003832 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057003833 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003834 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 324057003835 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 324057003836 active site 324057003837 metal binding site [ion binding]; metal-binding site 324057003838 homodimer interface [polypeptide binding]; other site 324057003839 catalytic site [active] 324057003840 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 324057003841 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057003842 HAMP domain; Region: HAMP; pfam00672 324057003843 Histidine kinase; Region: His_kinase; pfam06580 324057003844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057003845 ATP binding site [chemical binding]; other site 324057003846 Mg2+ binding site [ion binding]; other site 324057003847 G-X-G motif; other site 324057003848 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057003849 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057003850 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057003851 dimerization interface [polypeptide binding]; other site 324057003852 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057003853 Histidine kinase; Region: His_kinase; pfam06580 324057003854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057003855 ATP binding site [chemical binding]; other site 324057003856 Mg2+ binding site [ion binding]; other site 324057003857 G-X-G motif; other site 324057003858 Response regulator receiver domain; Region: Response_reg; pfam00072 324057003859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057003860 active site 324057003861 phosphorylation site [posttranslational modification] 324057003862 intermolecular recognition site; other site 324057003863 dimerization interface [polypeptide binding]; other site 324057003864 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057003865 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003866 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 324057003867 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057003868 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057003869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003870 dimer interface [polypeptide binding]; other site 324057003871 conserved gate region; other site 324057003872 putative PBP binding loops; other site 324057003873 ABC-ATPase subunit interface; other site 324057003874 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057003875 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057003876 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057003877 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057003878 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057003879 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057003880 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057003881 Helix-turn-helix domain; Region: HTH_18; pfam12833 324057003882 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003883 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 324057003884 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 324057003885 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 324057003886 Right handed beta helix region; Region: Beta_helix; pfam13229 324057003887 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057003888 Interdomain contacts; other site 324057003889 Cytokine receptor motif; other site 324057003890 Right handed beta helix region; Region: Beta_helix; pfam13229 324057003891 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_5; cd09621 324057003892 putative ligand binding site [chemical binding]; other site 324057003893 S-layer homology domain; Region: SLH; pfam00395 324057003894 S-layer homology domain; Region: SLH; pfam00395 324057003895 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 324057003896 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 324057003897 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057003898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003899 dimer interface [polypeptide binding]; other site 324057003900 conserved gate region; other site 324057003901 ABC-ATPase subunit interface; other site 324057003902 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057003903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003904 dimer interface [polypeptide binding]; other site 324057003905 conserved gate region; other site 324057003906 ABC-ATPase subunit interface; other site 324057003907 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057003908 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057003909 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 324057003910 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_5; cd09621 324057003911 putative ligand binding site [chemical binding]; other site 324057003912 S-layer homology domain; Region: SLH; pfam00395 324057003913 S-layer homology domain; Region: SLH; pfam00395 324057003914 S-layer homology domain; Region: SLH; pfam00395 324057003915 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057003916 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057003917 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057003918 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 324057003919 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 324057003920 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 324057003921 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 324057003922 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 324057003923 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 324057003924 metal binding site [ion binding]; metal-binding site 324057003925 substrate binding pocket [chemical binding]; other site 324057003926 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057003927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057003928 NAD(P) binding site [chemical binding]; other site 324057003929 active site 324057003930 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057003931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003932 dimer interface [polypeptide binding]; other site 324057003933 conserved gate region; other site 324057003934 ABC-ATPase subunit interface; other site 324057003935 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057003936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057003937 dimer interface [polypeptide binding]; other site 324057003938 conserved gate region; other site 324057003939 ABC-ATPase subunit interface; other site 324057003940 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057003941 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057003942 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057003943 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057003944 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003945 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057003946 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 324057003947 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 324057003948 tetramer interface [polypeptide binding]; other site 324057003949 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 324057003950 active site 324057003951 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 324057003952 active site 324057003953 dimer interface [polypeptide binding]; other site 324057003954 magnesium binding site [ion binding]; other site 324057003955 Predicted transcriptional regulators [Transcription]; Region: COG1733 324057003956 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 324057003957 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057003958 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057003959 dimer interface [polypeptide binding]; other site 324057003960 putative CheW interface [polypeptide binding]; other site 324057003961 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324057003962 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 324057003963 nucleotide binding site [chemical binding]; other site 324057003964 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 324057003965 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 324057003966 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057003967 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057003968 DNA binding site [nucleotide binding] 324057003969 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 324057003970 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 324057003971 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057003972 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057003973 Predicted membrane protein [Function unknown]; Region: COG1511 324057003974 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 324057003975 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 324057003976 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 324057003977 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 324057003978 Sulfatase; Region: Sulfatase; pfam00884 324057003979 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 324057003980 nucleoside/Zn binding site; other site 324057003981 dimer interface [polypeptide binding]; other site 324057003982 catalytic motif [active] 324057003983 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 324057003984 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 324057003985 Peptidase family M23; Region: Peptidase_M23; pfam01551 324057003986 lipoyl synthase; Provisional; Region: PRK05481 324057003987 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057003988 FeS/SAM binding site; other site 324057003989 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 324057003990 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 324057003991 ATP-NAD kinase; Region: NAD_kinase; pfam01513 324057003992 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 324057003993 Nucleoside recognition; Region: Gate; pfam07670 324057003994 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 324057003995 apolar tunnel; other site 324057003996 heme binding site [chemical binding]; other site 324057003997 dimerization interface [polypeptide binding]; other site 324057003998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 324057003999 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 324057004000 YycC-like protein; Region: YycC; pfam14174 324057004001 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 324057004002 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 324057004003 active site 324057004004 Zn binding site [ion binding]; other site 324057004005 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 324057004006 putative active site [active] 324057004007 HTH domain; Region: HTH_11; cl17392 324057004008 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 324057004009 FOG: CBS domain [General function prediction only]; Region: COG0517 324057004010 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 324057004011 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 324057004012 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 324057004013 putative active site [active] 324057004014 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 324057004015 active site 324057004016 multimer interface [polypeptide binding]; other site 324057004017 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 324057004018 active site 324057004019 intersubunit interactions; other site 324057004020 catalytic residue [active] 324057004021 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 324057004022 Chain length determinant protein; Region: Wzz; cl15801 324057004023 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 324057004024 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 324057004025 active site 324057004026 tetramer interface; other site 324057004027 Bacterial sugar transferase; Region: Bac_transf; pfam02397 324057004028 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 324057004029 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057004030 active site 324057004031 Cupin domain; Region: Cupin_2; cl17218 324057004032 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 324057004033 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 324057004034 Chain length determinant protein; Region: Wzz; cl15801 324057004035 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 324057004036 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 324057004037 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324057004038 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 324057004039 DXD motif; other site 324057004040 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 324057004041 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057004042 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057004043 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 324057004044 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 324057004045 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057004046 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057004047 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057004048 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057004049 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057004050 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 324057004051 putative ADP-binding pocket [chemical binding]; other site 324057004052 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 324057004053 active site 324057004054 metal-binding site [ion binding] 324057004055 nucleotide-binding site [chemical binding]; other site 324057004056 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 324057004057 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 324057004058 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324057004059 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 324057004060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057004061 Walker A/P-loop; other site 324057004062 ATP binding site [chemical binding]; other site 324057004063 Q-loop/lid; other site 324057004064 ABC transporter signature motif; other site 324057004065 Walker B; other site 324057004066 D-loop; other site 324057004067 H-loop/switch region; other site 324057004068 AAA domain; Region: AAA_31; pfam13614 324057004069 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 324057004070 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 324057004071 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 324057004072 ATP binding site [chemical binding]; other site 324057004073 Walker A motif; other site 324057004074 hexamer interface [polypeptide binding]; other site 324057004075 Walker B motif; other site 324057004076 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 324057004077 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 324057004078 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 324057004079 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 324057004080 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 324057004081 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 324057004082 phosphopeptide binding site; other site 324057004083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057004084 TIGR01777 family protein; Region: yfcH 324057004085 NAD(P) binding site [chemical binding]; other site 324057004086 active site 324057004087 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 324057004088 endonuclease IV; Provisional; Region: PRK01060 324057004089 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 324057004090 AP (apurinic/apyrimidinic) site pocket; other site 324057004091 DNA interaction; other site 324057004092 Metal-binding active site; metal-binding site 324057004093 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 324057004094 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 324057004095 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 324057004096 putative active site [active] 324057004097 putative substrate binding site [chemical binding]; other site 324057004098 putative cosubstrate binding site; other site 324057004099 catalytic site [active] 324057004100 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 324057004101 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 324057004102 TPP-binding site [chemical binding]; other site 324057004103 dimer interface [polypeptide binding]; other site 324057004104 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 324057004105 PYR/PP interface [polypeptide binding]; other site 324057004106 dimer interface [polypeptide binding]; other site 324057004107 TPP binding site [chemical binding]; other site 324057004108 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 324057004109 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 324057004110 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 324057004111 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 324057004112 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 324057004113 active site 324057004114 dimer interface [polypeptide binding]; other site 324057004115 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 324057004116 dimer interface [polypeptide binding]; other site 324057004117 active site 324057004118 Uncharacterized conserved protein [Function unknown]; Region: COG1739 324057004119 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 324057004120 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 324057004121 sulfate transport protein; Provisional; Region: cysT; CHL00187 324057004122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004123 dimer interface [polypeptide binding]; other site 324057004124 conserved gate region; other site 324057004125 putative PBP binding loops; other site 324057004126 ABC-ATPase subunit interface; other site 324057004127 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 324057004128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004129 dimer interface [polypeptide binding]; other site 324057004130 conserved gate region; other site 324057004131 putative PBP binding loops; other site 324057004132 ABC-ATPase subunit interface; other site 324057004133 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 324057004134 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 324057004135 Walker A/P-loop; other site 324057004136 ATP binding site [chemical binding]; other site 324057004137 Q-loop/lid; other site 324057004138 ABC transporter signature motif; other site 324057004139 Walker B; other site 324057004140 D-loop; other site 324057004141 H-loop/switch region; other site 324057004142 TOBE domain; Region: TOBE_2; pfam08402 324057004143 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 324057004144 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 324057004145 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057004146 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 324057004147 active site 324057004148 motif I; other site 324057004149 motif II; other site 324057004150 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057004151 motif II; other site 324057004152 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 324057004153 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 324057004154 C-terminal peptidase (prc); Region: prc; TIGR00225 324057004155 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 324057004156 protein binding site [polypeptide binding]; other site 324057004157 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 324057004158 Catalytic dyad [active] 324057004159 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 324057004160 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 324057004161 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 324057004162 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 324057004163 Ferritin-like domain; Region: Ferritin; pfam00210 324057004164 ferroxidase diiron center [ion binding]; other site 324057004165 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 324057004166 Part of AAA domain; Region: AAA_19; pfam13245 324057004167 Family description; Region: UvrD_C_2; pfam13538 324057004168 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324057004169 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057004170 Coenzyme A binding pocket [chemical binding]; other site 324057004171 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057004172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057004173 Coenzyme A binding pocket [chemical binding]; other site 324057004174 ferric uptake regulator; Provisional; Region: fur; PRK09462 324057004175 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 324057004176 metal binding site 2 [ion binding]; metal-binding site 324057004177 putative DNA binding helix; other site 324057004178 metal binding site 1 [ion binding]; metal-binding site 324057004179 dimer interface [polypeptide binding]; other site 324057004180 structural Zn2+ binding site [ion binding]; other site 324057004181 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 324057004182 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 324057004183 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 324057004184 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 324057004185 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324057004186 RNA binding surface [nucleotide binding]; other site 324057004187 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 324057004188 active site 324057004189 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057004190 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 324057004191 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 324057004192 active site 324057004193 substrate binding sites [chemical binding]; other site 324057004194 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 324057004195 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 324057004196 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 324057004197 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 324057004198 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 324057004199 Substrate-binding site [chemical binding]; other site 324057004200 Substrate specificity [chemical binding]; other site 324057004201 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 324057004202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057004203 putative substrate translocation pore; other site 324057004204 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 324057004205 putative DNA binding site [nucleotide binding]; other site 324057004206 putative Zn2+ binding site [ion binding]; other site 324057004207 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324057004208 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 324057004209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 324057004210 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 324057004211 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 324057004212 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057004213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057004214 S-adenosylmethionine binding site [chemical binding]; other site 324057004215 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 324057004216 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 324057004217 active site 324057004218 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057004219 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 324057004220 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324057004221 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 324057004222 DXD motif; other site 324057004223 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 324057004224 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 324057004225 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 324057004226 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 324057004227 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 324057004228 23S rRNA binding site [nucleotide binding]; other site 324057004229 L21 binding site [polypeptide binding]; other site 324057004230 L13 binding site [polypeptide binding]; other site 324057004231 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057004232 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004233 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057004234 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004235 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 324057004236 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 324057004237 Ca binding site [ion binding]; other site 324057004238 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 324057004239 Ca binding site [ion binding]; other site 324057004240 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057004241 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057004242 dimerization interface [polypeptide binding]; other site 324057004243 Histidine kinase; Region: His_kinase; pfam06580 324057004244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004245 ATP binding site [chemical binding]; other site 324057004246 Mg2+ binding site [ion binding]; other site 324057004247 G-X-G motif; other site 324057004248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057004249 active site 324057004250 phosphorylation site [posttranslational modification] 324057004251 intermolecular recognition site; other site 324057004252 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004253 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057004254 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004255 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057004256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004257 dimer interface [polypeptide binding]; other site 324057004258 conserved gate region; other site 324057004259 ABC-ATPase subunit interface; other site 324057004260 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057004261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004262 dimer interface [polypeptide binding]; other site 324057004263 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 324057004264 ABC-ATPase subunit interface; other site 324057004265 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057004266 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057004267 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 324057004268 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057004269 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057004270 Coenzyme A binding pocket [chemical binding]; other site 324057004271 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 324057004272 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 324057004273 PYR/PP interface [polypeptide binding]; other site 324057004274 dimer interface [polypeptide binding]; other site 324057004275 TPP binding site [chemical binding]; other site 324057004276 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 324057004277 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 324057004278 TPP-binding site [chemical binding]; other site 324057004279 dimer interface [polypeptide binding]; other site 324057004280 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 324057004281 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 324057004282 putative valine binding site [chemical binding]; other site 324057004283 dimer interface [polypeptide binding]; other site 324057004284 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 324057004285 ketol-acid reductoisomerase; Provisional; Region: PRK05479 324057004286 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 324057004287 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 324057004288 2-isopropylmalate synthase; Validated; Region: PRK00915 324057004289 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 324057004290 active site 324057004291 catalytic residues [active] 324057004292 metal binding site [ion binding]; metal-binding site 324057004293 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 324057004294 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 324057004295 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 324057004296 tartrate dehydrogenase; Region: TTC; TIGR02089 324057004297 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 324057004298 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 324057004299 dimer interface [polypeptide binding]; other site 324057004300 decamer (pentamer of dimers) interface [polypeptide binding]; other site 324057004301 catalytic triad [active] 324057004302 peroxidatic and resolving cysteines [active] 324057004303 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057004304 Spore germination protein; Region: Spore_permease; cl17796 324057004305 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057004306 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057004307 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 324057004308 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057004309 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 324057004310 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 324057004311 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057004312 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 324057004313 putative active site [active] 324057004314 heme pocket [chemical binding]; other site 324057004315 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057004316 dimer interface [polypeptide binding]; other site 324057004317 phosphorylation site [posttranslational modification] 324057004318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004319 ATP binding site [chemical binding]; other site 324057004320 Mg2+ binding site [ion binding]; other site 324057004321 G-X-G motif; other site 324057004322 multifunctional aminopeptidase A; Provisional; Region: PRK00913 324057004323 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 324057004324 interface (dimer of trimers) [polypeptide binding]; other site 324057004325 Substrate-binding/catalytic site; other site 324057004326 Zn-binding sites [ion binding]; other site 324057004327 Response regulator receiver domain; Region: Response_reg; pfam00072 324057004328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057004329 active site 324057004330 phosphorylation site [posttranslational modification] 324057004331 intermolecular recognition site; other site 324057004332 dimerization interface [polypeptide binding]; other site 324057004333 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057004334 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057004335 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057004336 dimerization interface [polypeptide binding]; other site 324057004337 Histidine kinase; Region: His_kinase; pfam06580 324057004338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004339 ATP binding site [chemical binding]; other site 324057004340 Mg2+ binding site [ion binding]; other site 324057004341 G-X-G motif; other site 324057004342 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057004343 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057004344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004345 dimer interface [polypeptide binding]; other site 324057004346 conserved gate region; other site 324057004347 putative PBP binding loops; other site 324057004348 ABC-ATPase subunit interface; other site 324057004349 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057004350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004351 dimer interface [polypeptide binding]; other site 324057004352 conserved gate region; other site 324057004353 ABC-ATPase subunit interface; other site 324057004354 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 324057004355 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 324057004356 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 324057004357 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 324057004358 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 324057004359 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 324057004360 inhibitor binding site; inhibition site 324057004361 active site 324057004362 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 324057004363 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 324057004364 putative active site [active] 324057004365 putative FMN binding site [chemical binding]; other site 324057004366 putative substrate binding site [chemical binding]; other site 324057004367 putative catalytic residue [active] 324057004368 A new structural DNA glycosylase; Region: AlkD_like; cd06561 324057004369 active site 324057004370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057004371 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057004372 putative substrate translocation pore; other site 324057004373 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057004374 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057004375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004376 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 324057004377 intracellular protease, PfpI family; Region: PfpI; TIGR01382 324057004378 conserved cys residue [active] 324057004379 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057004380 HAMP domain; Region: HAMP; pfam00672 324057004381 Histidine kinase; Region: His_kinase; pfam06580 324057004382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004383 ATP binding site [chemical binding]; other site 324057004384 Mg2+ binding site [ion binding]; other site 324057004385 G-X-G motif; other site 324057004386 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057004387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057004388 active site 324057004389 phosphorylation site [posttranslational modification] 324057004390 intermolecular recognition site; other site 324057004391 dimerization interface [polypeptide binding]; other site 324057004392 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004394 dimer interface [polypeptide binding]; other site 324057004395 conserved gate region; other site 324057004396 putative PBP binding loops; other site 324057004397 ABC-ATPase subunit interface; other site 324057004398 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057004399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004400 dimer interface [polypeptide binding]; other site 324057004401 conserved gate region; other site 324057004402 putative PBP binding loops; other site 324057004403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057004404 ABC-ATPase subunit interface; other site 324057004405 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057004406 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057004407 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 324057004408 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 324057004409 substrate binding [chemical binding]; other site 324057004410 active site 324057004411 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 324057004412 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 324057004413 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 324057004414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057004415 putative substrate translocation pore; other site 324057004416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057004417 Response regulator receiver domain; Region: Response_reg; pfam00072 324057004418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057004419 active site 324057004420 phosphorylation site [posttranslational modification] 324057004421 intermolecular recognition site; other site 324057004422 dimerization interface [polypeptide binding]; other site 324057004423 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004424 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057004425 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004426 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057004427 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057004428 dimerization interface [polypeptide binding]; other site 324057004429 Histidine kinase; Region: His_kinase; pfam06580 324057004430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004431 ATP binding site [chemical binding]; other site 324057004432 Mg2+ binding site [ion binding]; other site 324057004433 G-X-G motif; other site 324057004434 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 324057004435 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057004436 ligand binding site [chemical binding]; other site 324057004437 PAS domain S-box; Region: sensory_box; TIGR00229 324057004438 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057004439 putative active site [active] 324057004440 heme pocket [chemical binding]; other site 324057004441 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 324057004442 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057004443 putative active site [active] 324057004444 heme pocket [chemical binding]; other site 324057004445 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 324057004446 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057004447 putative active site [active] 324057004448 heme pocket [chemical binding]; other site 324057004449 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057004450 dimer interface [polypeptide binding]; other site 324057004451 phosphorylation site [posttranslational modification] 324057004452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004453 ATP binding site [chemical binding]; other site 324057004454 Mg2+ binding site [ion binding]; other site 324057004455 G-X-G motif; other site 324057004456 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057004457 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057004458 DNA binding site [nucleotide binding] 324057004459 domain linker motif; other site 324057004460 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057004461 ligand binding site [chemical binding]; other site 324057004462 dimerization interface [polypeptide binding]; other site 324057004463 L-fucose isomerase; Provisional; Region: fucI; PRK10991 324057004464 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 324057004465 hexamer (dimer of trimers) interface [polypeptide binding]; other site 324057004466 trimer interface [polypeptide binding]; other site 324057004467 substrate binding site [chemical binding]; other site 324057004468 Mn binding site [ion binding]; other site 324057004469 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 324057004470 intersubunit interface [polypeptide binding]; other site 324057004471 active site 324057004472 Zn2+ binding site [ion binding]; other site 324057004473 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 324057004474 N- and C-terminal domain interface [polypeptide binding]; other site 324057004475 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 324057004476 active site 324057004477 putative catalytic site [active] 324057004478 metal binding site [ion binding]; metal-binding site 324057004479 ATP binding site [chemical binding]; other site 324057004480 carbohydrate binding site [chemical binding]; other site 324057004481 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 324057004482 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 324057004483 Mor transcription activator family; Region: Mor; cl02360 324057004484 Transcriptional regulators [Transcription]; Region: FadR; COG2186 324057004485 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057004486 DNA-binding site [nucleotide binding]; DNA binding site 324057004487 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 324057004488 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057004489 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057004490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004491 dimer interface [polypeptide binding]; other site 324057004492 conserved gate region; other site 324057004493 putative PBP binding loops; other site 324057004494 ABC-ATPase subunit interface; other site 324057004495 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057004496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004497 dimer interface [polypeptide binding]; other site 324057004498 conserved gate region; other site 324057004499 putative PBP binding loops; other site 324057004500 ABC-ATPase subunit interface; other site 324057004501 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 324057004502 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 324057004503 homodimer interface [polypeptide binding]; other site 324057004504 substrate-cofactor binding pocket; other site 324057004505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057004506 catalytic residue [active] 324057004507 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 324057004508 active site 324057004509 acetylornithine aminotransferase; Provisional; Region: PRK02627 324057004510 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324057004511 inhibitor-cofactor binding pocket; inhibition site 324057004512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057004513 catalytic residue [active] 324057004514 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 324057004515 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 324057004516 Protein of unknown function (DUF445); Region: DUF445; pfam04286 324057004517 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 324057004518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057004519 Walker A/P-loop; other site 324057004520 ATP binding site [chemical binding]; other site 324057004521 Q-loop/lid; other site 324057004522 ABC transporter signature motif; other site 324057004523 Walker B; other site 324057004524 D-loop; other site 324057004525 H-loop/switch region; other site 324057004526 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 324057004527 Predicted transcriptional regulators [Transcription]; Region: COG1733 324057004528 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 324057004529 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 324057004530 dimerization interface [polypeptide binding]; other site 324057004531 active site 324057004532 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 324057004533 active site 324057004534 catalytic residues [active] 324057004535 metal binding site [ion binding]; metal-binding site 324057004536 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 324057004537 Coenzyme A binding pocket [chemical binding]; other site 324057004538 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057004539 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 324057004540 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 324057004541 metal ion-dependent adhesion site (MIDAS); other site 324057004542 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 324057004543 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 324057004544 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057004545 motif II; other site 324057004546 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 324057004547 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 324057004548 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 324057004549 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 324057004550 putative active site [active] 324057004551 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 324057004552 putative active site pocket [active] 324057004553 dimerization interface [polypeptide binding]; other site 324057004554 putative catalytic residue [active] 324057004555 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 324057004556 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057004557 dimerization interface [polypeptide binding]; other site 324057004558 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057004559 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057004560 dimer interface [polypeptide binding]; other site 324057004561 putative CheW interface [polypeptide binding]; other site 324057004562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057004563 putative substrate translocation pore; other site 324057004564 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057004565 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057004566 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057004567 putative Zn2+ binding site [ion binding]; other site 324057004568 putative DNA binding site [nucleotide binding]; other site 324057004569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324057004570 Histidine kinase; Region: HisKA_3; pfam07730 324057004571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004572 ATP binding site [chemical binding]; other site 324057004573 Mg2+ binding site [ion binding]; other site 324057004574 G-X-G motif; other site 324057004575 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057004576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057004577 active site 324057004578 phosphorylation site [posttranslational modification] 324057004579 intermolecular recognition site; other site 324057004580 dimerization interface [polypeptide binding]; other site 324057004581 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057004582 DNA binding residues [nucleotide binding] 324057004583 dimerization interface [polypeptide binding]; other site 324057004584 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 324057004585 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 324057004586 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 324057004587 dimer interface [polypeptide binding]; other site 324057004588 motif 1; other site 324057004589 active site 324057004590 motif 2; other site 324057004591 motif 3; other site 324057004592 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 324057004593 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 324057004594 putative tRNA-binding site [nucleotide binding]; other site 324057004595 B3/4 domain; Region: B3_4; pfam03483 324057004596 tRNA synthetase B5 domain; Region: B5; smart00874 324057004597 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 324057004598 dimer interface [polypeptide binding]; other site 324057004599 motif 1; other site 324057004600 motif 3; other site 324057004601 motif 2; other site 324057004602 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 324057004603 Cell division protein ZapA; Region: ZapA; cl01146 324057004604 short chain dehydrogenase; Provisional; Region: PRK08703 324057004605 classical (c) SDRs; Region: SDR_c; cd05233 324057004606 NAD(P) binding site [chemical binding]; other site 324057004607 active site 324057004608 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 324057004609 Membrane protein of unknown function; Region: DUF360; pfam04020 324057004610 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 324057004611 MutS domain III; Region: MutS_III; pfam05192 324057004612 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 324057004613 Walker A/P-loop; other site 324057004614 ATP binding site [chemical binding]; other site 324057004615 Q-loop/lid; other site 324057004616 ABC transporter signature motif; other site 324057004617 Walker B; other site 324057004618 D-loop; other site 324057004619 H-loop/switch region; other site 324057004620 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 324057004621 Smr domain; Region: Smr; pfam01713 324057004622 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 324057004623 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 324057004624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057004625 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057004626 putative substrate translocation pore; other site 324057004627 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 324057004628 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 324057004629 dimer interface [polypeptide binding]; other site 324057004630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057004631 catalytic residue [active] 324057004632 CotH protein; Region: CotH; pfam08757 324057004633 C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD); Region: AP_MHD_Cterm; cl10970 324057004634 Spore germination protein; Region: Spore_permease; cl17796 324057004635 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057004636 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057004637 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057004638 Coat F domain; Region: Coat_F; pfam07875 324057004639 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 324057004640 AsnC family; Region: AsnC_trans_reg; pfam01037 324057004641 hypothetical protein; Validated; Region: PRK07682 324057004642 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057004643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057004644 homodimer interface [polypeptide binding]; other site 324057004645 catalytic residue [active] 324057004646 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 324057004647 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 324057004648 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 324057004649 active site 324057004650 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 324057004651 ArsC family; Region: ArsC; pfam03960 324057004652 putative ArsC-like catalytic residues; other site 324057004653 putative TRX-like catalytic residues [active] 324057004654 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 324057004655 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057004656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057004657 homodimer interface [polypeptide binding]; other site 324057004658 catalytic residue [active] 324057004659 5'-3' exonuclease; Region: 53EXOc; smart00475 324057004660 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 324057004661 active site 324057004662 metal binding site 1 [ion binding]; metal-binding site 324057004663 putative 5' ssDNA interaction site; other site 324057004664 metal binding site 3; metal-binding site 324057004665 metal binding site 2 [ion binding]; metal-binding site 324057004666 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 324057004667 putative DNA binding site [nucleotide binding]; other site 324057004668 putative metal binding site [ion binding]; other site 324057004669 TGF-beta propeptide; Region: TGFb_propeptide; pfam00688 324057004670 S-layer homology domain; Region: SLH; pfam00395 324057004671 S-layer homology domain; Region: SLH; pfam00395 324057004672 S-layer homology domain; Region: SLH; pfam00395 324057004673 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 324057004674 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 324057004675 Phage Tail Collar Domain; Region: Collar; pfam07484 324057004676 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 324057004677 Phage Tail Collar Domain; Region: Collar; pfam07484 324057004678 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 324057004679 Phage Tail Collar Domain; Region: Collar; pfam07484 324057004680 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 324057004681 HRDC domain; Region: HRDC; pfam00570 324057004682 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 324057004683 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 324057004684 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 324057004685 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 324057004686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057004687 NAD(P) binding site [chemical binding]; other site 324057004688 active site 324057004689 helicase 45; Provisional; Region: PTZ00424 324057004690 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 324057004691 ATP binding site [chemical binding]; other site 324057004692 Mg++ binding site [ion binding]; other site 324057004693 motif III; other site 324057004694 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057004695 nucleotide binding region [chemical binding]; other site 324057004696 ATP-binding site [chemical binding]; other site 324057004697 S-layer homology domain; Region: SLH; pfam00395 324057004698 S-layer homology domain; Region: SLH; pfam00395 324057004699 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 324057004700 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 324057004701 Walker A/P-loop; other site 324057004702 ATP binding site [chemical binding]; other site 324057004703 Q-loop/lid; other site 324057004704 ABC transporter signature motif; other site 324057004705 Walker B; other site 324057004706 D-loop; other site 324057004707 H-loop/switch region; other site 324057004708 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 324057004709 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057004710 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 324057004711 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057004712 homodimer interface [polypeptide binding]; other site 324057004713 catalytic residue [active] 324057004714 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057004715 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057004716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004717 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 324057004718 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057004719 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057004720 secreted effector protein PipB2; Provisional; Region: PRK15196 324057004721 secreted effector protein PipB2; Provisional; Region: PRK15196 324057004722 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 324057004723 active site 324057004724 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 324057004725 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057004726 active site 324057004727 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 324057004728 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 324057004729 Probable Catalytic site; other site 324057004730 metal-binding site 324057004731 flagellar assembly protein H; Validated; Region: fliH; PRK05687 324057004732 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 324057004733 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 324057004734 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 324057004735 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 324057004736 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 324057004737 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 324057004738 dimer interface [polypeptide binding]; other site 324057004739 active site 324057004740 CoA binding pocket [chemical binding]; other site 324057004741 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 324057004742 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 324057004743 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057004744 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057004745 DNA binding residues [nucleotide binding] 324057004746 dimerization interface [polypeptide binding]; other site 324057004747 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 324057004748 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 324057004749 tetramer interface [polypeptide binding]; other site 324057004750 heme binding pocket [chemical binding]; other site 324057004751 Response regulator receiver domain; Region: Response_reg; pfam00072 324057004752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057004753 active site 324057004754 phosphorylation site [posttranslational modification] 324057004755 intermolecular recognition site; other site 324057004756 dimerization interface [polypeptide binding]; other site 324057004757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004758 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057004759 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004760 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057004761 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057004762 dimerization interface [polypeptide binding]; other site 324057004763 Histidine kinase; Region: His_kinase; pfam06580 324057004764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004765 ATP binding site [chemical binding]; other site 324057004766 Mg2+ binding site [ion binding]; other site 324057004767 G-X-G motif; other site 324057004768 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057004769 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057004770 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057004771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004772 dimer interface [polypeptide binding]; other site 324057004773 conserved gate region; other site 324057004774 putative PBP binding loops; other site 324057004775 ABC-ATPase subunit interface; other site 324057004776 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057004777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004778 dimer interface [polypeptide binding]; other site 324057004779 conserved gate region; other site 324057004780 putative PBP binding loops; other site 324057004781 ABC-ATPase subunit interface; other site 324057004782 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 324057004783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 324057004784 TPR repeat; Region: TPR_11; pfam13414 324057004785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057004786 binding surface 324057004787 TPR motif; other site 324057004788 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 324057004789 binding surface 324057004790 TPR motif; other site 324057004791 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 324057004792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004793 ATP binding site [chemical binding]; other site 324057004794 Mg2+ binding site [ion binding]; other site 324057004795 G-X-G motif; other site 324057004796 SWIM zinc finger; Region: SWIM; pfam04434 324057004797 SNF2 Helicase protein; Region: DUF3670; pfam12419 324057004798 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 324057004799 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057004800 ATP binding site [chemical binding]; other site 324057004801 putative Mg++ binding site [ion binding]; other site 324057004802 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057004803 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 324057004804 nucleotide binding region [chemical binding]; other site 324057004805 ATP-binding site [chemical binding]; other site 324057004806 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057004807 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057004808 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 324057004809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004810 dimer interface [polypeptide binding]; other site 324057004811 conserved gate region; other site 324057004812 putative PBP binding loops; other site 324057004813 ABC-ATPase subunit interface; other site 324057004814 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057004815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004816 dimer interface [polypeptide binding]; other site 324057004817 conserved gate region; other site 324057004818 putative PBP binding loops; other site 324057004819 ABC-ATPase subunit interface; other site 324057004820 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057004821 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057004822 dimerization interface [polypeptide binding]; other site 324057004823 Histidine kinase; Region: His_kinase; pfam06580 324057004824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004825 ATP binding site [chemical binding]; other site 324057004826 Mg2+ binding site [ion binding]; other site 324057004827 G-X-G motif; other site 324057004828 Response regulator receiver domain; Region: Response_reg; pfam00072 324057004829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057004830 active site 324057004831 phosphorylation site [posttranslational modification] 324057004832 intermolecular recognition site; other site 324057004833 dimerization interface [polypeptide binding]; other site 324057004834 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004835 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057004836 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004837 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 324057004838 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 324057004839 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 324057004840 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 324057004841 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324057004842 inhibitor-cofactor binding pocket; inhibition site 324057004843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057004844 catalytic residue [active] 324057004845 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 324057004846 AAA domain; Region: AAA_26; pfam13500 324057004847 biotin synthase; Validated; Region: PRK06256 324057004848 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057004849 FeS/SAM binding site; other site 324057004850 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 324057004851 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 324057004852 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 324057004853 substrate-cofactor binding pocket; other site 324057004854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057004855 catalytic residue [active] 324057004856 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 324057004857 TAP-like protein; Region: Abhydrolase_4; pfam08386 324057004858 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 324057004859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057004860 S-adenosylmethionine binding site [chemical binding]; other site 324057004861 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 324057004862 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057004863 motif II; other site 324057004864 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 324057004865 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324057004866 DNA binding residues [nucleotide binding] 324057004867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057004868 short chain dehydrogenase; Provisional; Region: PRK06197 324057004869 NAD(P) binding site [chemical binding]; other site 324057004870 active site 324057004871 NADH(P)-binding; Region: NAD_binding_10; pfam13460 324057004872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057004873 NAD(P) binding site [chemical binding]; other site 324057004874 active site 324057004875 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 324057004876 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 324057004877 NADP+ binding site [chemical binding]; other site 324057004878 RibD C-terminal domain; Region: RibD_C; cl17279 324057004879 haloalkane dehalogenase; Provisional; Region: PRK03204 324057004880 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 324057004881 Predicted transcriptional regulators [Transcription]; Region: COG1733 324057004882 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057004883 dimerization interface [polypeptide binding]; other site 324057004884 putative DNA binding site [nucleotide binding]; other site 324057004885 putative Zn2+ binding site [ion binding]; other site 324057004886 hypothetical protein; Validated; Region: PRK07581 324057004887 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 324057004888 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057004889 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057004890 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057004891 dimerization interface [polypeptide binding]; other site 324057004892 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 324057004893 metal ion-dependent adhesion site (MIDAS); other site 324057004894 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 324057004895 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057004896 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057004897 active site 324057004898 catalytic tetrad [active] 324057004899 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 324057004900 nudix motif; other site 324057004901 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 324057004902 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 324057004903 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057004904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004905 dimer interface [polypeptide binding]; other site 324057004906 conserved gate region; other site 324057004907 ABC-ATPase subunit interface; other site 324057004908 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057004909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057004910 dimer interface [polypeptide binding]; other site 324057004911 conserved gate region; other site 324057004912 putative PBP binding loops; other site 324057004913 ABC-ATPase subunit interface; other site 324057004914 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057004915 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004916 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057004917 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004918 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 324057004919 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 324057004920 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 324057004921 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 324057004922 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 324057004923 putative ligand binding site [chemical binding]; other site 324057004924 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 324057004925 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 324057004926 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 324057004927 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 324057004928 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 324057004929 Glyco_18 domain; Region: Glyco_18; smart00636 324057004930 active site 324057004931 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057004932 DinB superfamily; Region: DinB_2; pfam12867 324057004933 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057004934 Zn2+ binding site [ion binding]; other site 324057004935 Mg2+ binding site [ion binding]; other site 324057004936 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 324057004937 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 324057004938 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 324057004939 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057004940 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 324057004941 putative active site [active] 324057004942 heme pocket [chemical binding]; other site 324057004943 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 324057004944 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057004945 putative active site [active] 324057004946 heme pocket [chemical binding]; other site 324057004947 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057004948 dimer interface [polypeptide binding]; other site 324057004949 phosphorylation site [posttranslational modification] 324057004950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004951 ATP binding site [chemical binding]; other site 324057004952 Mg2+ binding site [ion binding]; other site 324057004953 G-X-G motif; other site 324057004954 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 324057004955 Sodium Bile acid symporter family; Region: SBF; cl17470 324057004956 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057004957 dimerization interface [polypeptide binding]; other site 324057004958 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324057004959 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057004960 putative active site [active] 324057004961 heme pocket [chemical binding]; other site 324057004962 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057004963 dimer interface [polypeptide binding]; other site 324057004964 phosphorylation site [posttranslational modification] 324057004965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057004966 ATP binding site [chemical binding]; other site 324057004967 Mg2+ binding site [ion binding]; other site 324057004968 G-X-G motif; other site 324057004969 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057004970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057004971 active site 324057004972 phosphorylation site [posttranslational modification] 324057004973 intermolecular recognition site; other site 324057004974 dimerization interface [polypeptide binding]; other site 324057004975 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057004976 DNA binding site [nucleotide binding] 324057004977 Cupin domain; Region: Cupin_2; pfam07883 324057004978 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057004979 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057004980 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 324057004981 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 324057004982 dimerization interface [polypeptide binding]; other site 324057004983 ligand binding site [chemical binding]; other site 324057004984 NADP binding site [chemical binding]; other site 324057004985 catalytic site [active] 324057004986 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 324057004987 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 324057004988 GIY-YIG motif/motif A; other site 324057004989 active site 324057004990 catalytic site [active] 324057004991 putative DNA binding site [nucleotide binding]; other site 324057004992 metal binding site [ion binding]; metal-binding site 324057004993 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 324057004994 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 324057004995 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057004996 Coenzyme A binding pocket [chemical binding]; other site 324057004997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 324057004998 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 324057004999 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 324057005000 active site 324057005001 Zn binding site [ion binding]; other site 324057005002 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 324057005003 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 324057005004 metal binding site [ion binding]; metal-binding site 324057005005 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057005006 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005007 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005009 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 324057005010 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 324057005011 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 324057005012 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 324057005013 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 324057005014 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 324057005015 active site 324057005016 HIGH motif; other site 324057005017 dimer interface [polypeptide binding]; other site 324057005018 KMSKS motif; other site 324057005019 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324057005020 RNA binding surface [nucleotide binding]; other site 324057005021 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057005022 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 324057005023 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 324057005024 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057005025 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057005026 dimer interface [polypeptide binding]; other site 324057005027 putative CheW interface [polypeptide binding]; other site 324057005028 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 324057005029 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 324057005030 Walker A/P-loop; other site 324057005031 ATP binding site [chemical binding]; other site 324057005032 Q-loop/lid; other site 324057005033 ABC transporter signature motif; other site 324057005034 Walker B; other site 324057005035 D-loop; other site 324057005036 H-loop/switch region; other site 324057005037 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 324057005038 PhoU domain; Region: PhoU; pfam01895 324057005039 PhoU domain; Region: PhoU; pfam01895 324057005040 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 324057005041 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 324057005042 S-layer homology domain; Region: SLH; pfam00395 324057005043 S-layer homology domain; Region: SLH; pfam00395 324057005044 S-layer homology domain; Region: SLH; pfam00395 324057005045 DNA polymerase I; Provisional; Region: PRK05755 324057005046 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 324057005047 active site 324057005048 metal binding site 1 [ion binding]; metal-binding site 324057005049 putative 5' ssDNA interaction site; other site 324057005050 metal binding site 3; metal-binding site 324057005051 metal binding site 2 [ion binding]; metal-binding site 324057005052 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 324057005053 putative DNA binding site [nucleotide binding]; other site 324057005054 putative metal binding site [ion binding]; other site 324057005055 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 324057005056 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 324057005057 active site 324057005058 DNA binding site [nucleotide binding] 324057005059 catalytic site [active] 324057005060 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 324057005061 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 324057005062 DNA binding site [nucleotide binding] 324057005063 catalytic residue [active] 324057005064 H2TH interface [polypeptide binding]; other site 324057005065 putative catalytic residues [active] 324057005066 turnover-facilitating residue; other site 324057005067 intercalation triad [nucleotide binding]; other site 324057005068 8OG recognition residue [nucleotide binding]; other site 324057005069 putative reading head residues; other site 324057005070 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 324057005071 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 324057005072 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 324057005073 Domain of unknown function DUF; Region: DUF204; pfam02659 324057005074 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 324057005075 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 324057005076 CoA-binding site [chemical binding]; other site 324057005077 ATP-binding [chemical binding]; other site 324057005078 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 324057005079 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 324057005080 N-acetyl-D-glucosamine binding site [chemical binding]; other site 324057005081 catalytic residue [active] 324057005082 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 324057005083 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 324057005084 ATP cone domain; Region: ATP-cone; pfam03477 324057005085 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 324057005086 dimer interface [polypeptide binding]; other site 324057005087 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057005088 metal binding site [ion binding]; metal-binding site 324057005089 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 324057005090 active site 324057005091 catalytic triad [active] 324057005092 oxyanion hole [active] 324057005093 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 324057005094 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 324057005095 Phage-related protein [Function unknown]; Region: COG4695; cl01923 324057005096 Phage portal protein; Region: Phage_portal; pfam04860 324057005097 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 324057005098 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 324057005099 Phage capsid family; Region: Phage_capsid; pfam05065 324057005100 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 324057005101 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 324057005102 Phage major tail protein 2; Region: Phage_tail_2; cl11463 324057005103 Phage-related protein [Function unknown]; Region: COG5412 324057005104 VirE N-terminal domain; Region: VirE_N; pfam08800 324057005105 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 324057005106 Holin family; Region: Phage_holin_4; pfam05105 324057005107 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 324057005108 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 324057005109 active site 324057005110 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057005111 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 324057005112 Mg binding site [ion binding]; other site 324057005113 nucleotide binding site [chemical binding]; other site 324057005114 putative protofilament interface [polypeptide binding]; other site 324057005115 AAA-like domain; Region: AAA_10; pfam12846 324057005116 Accessory gene regulator B; Region: AgrB; pfam04647 324057005117 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057005118 non-specific DNA binding site [nucleotide binding]; other site 324057005119 salt bridge; other site 324057005120 sequence-specific DNA binding site [nucleotide binding]; other site 324057005121 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324057005122 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057005123 non-specific DNA binding site [nucleotide binding]; other site 324057005124 salt bridge; other site 324057005125 sequence-specific DNA binding site [nucleotide binding]; other site 324057005126 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 324057005127 Catalytic site [active] 324057005128 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057005129 sequence-specific DNA binding site [nucleotide binding]; other site 324057005130 salt bridge; other site 324057005131 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 324057005132 ORF6C domain; Region: ORF6C; pfam10552 324057005133 AAA domain; Region: AAA_23; pfam13476 324057005134 P-loop containing region of AAA domain; Region: AAA_29; cl17516 324057005135 RecT family; Region: RecT; pfam03837 324057005136 HNH endonuclease; Region: HNH_3; pfam13392 324057005137 AP2 domain; Region: AP2; pfam00847 324057005138 DNA binding site [nucleotide binding] 324057005139 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 324057005140 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 324057005141 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 324057005142 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 324057005143 replicative DNA helicase; Region: DnaB; TIGR00665 324057005144 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 324057005145 Walker A motif; other site 324057005146 ATP binding site [chemical binding]; other site 324057005147 Walker B motif; other site 324057005148 DNA binding loops [nucleotide binding] 324057005149 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 324057005150 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 324057005151 active site 324057005152 putative DNA-binding cleft [nucleotide binding]; other site 324057005153 dimer interface [polypeptide binding]; other site 324057005154 HNH endonuclease; Region: HNH_3; pfam13392 324057005155 dUTPase; Region: dUTPase_2; pfam08761 324057005156 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 324057005157 active site 324057005158 homodimer interface [polypeptide binding]; other site 324057005159 metal binding site [ion binding]; metal-binding site 324057005160 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 324057005161 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 324057005162 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 324057005163 cofactor binding site; other site 324057005164 DNA binding site [nucleotide binding] 324057005165 substrate interaction site [chemical binding]; other site 324057005166 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 324057005167 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 324057005168 DNA methylase; Region: N6_N4_Mtase; pfam01555 324057005169 positive control sigma-like factor; Validated; Region: PRK06930 324057005170 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057005171 DNA binding residues [nucleotide binding] 324057005172 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 324057005173 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 324057005174 catalytic residues [active] 324057005175 catalytic nucleophile [active] 324057005176 Recombinase; Region: Recombinase; pfam07508 324057005177 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 324057005178 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 324057005179 KWG Leptospira; Region: KWG; pfam07656 324057005180 KWG Leptospira; Region: KWG; pfam07656 324057005181 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 324057005182 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 324057005183 active site 324057005184 S-layer homology domain; Region: SLH; pfam00395 324057005185 S-layer homology domain; Region: SLH; pfam00395 324057005186 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 324057005187 BNR repeat-like domain; Region: BNR_2; pfam13088 324057005188 Asp-box motif; other site 324057005189 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 324057005190 Asp-box motif; other site 324057005191 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 324057005192 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057005193 DNA-binding site [nucleotide binding]; DNA binding site 324057005194 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 324057005195 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057005196 dimerization interface [polypeptide binding]; other site 324057005197 ligand binding site [chemical binding]; other site 324057005198 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324057005199 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057005200 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 324057005201 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057005202 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 324057005203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005204 dimer interface [polypeptide binding]; other site 324057005205 conserved gate region; other site 324057005206 putative PBP binding loops; other site 324057005207 ABC-ATPase subunit interface; other site 324057005208 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005210 dimer interface [polypeptide binding]; other site 324057005211 conserved gate region; other site 324057005212 putative PBP binding loops; other site 324057005213 ABC-ATPase subunit interface; other site 324057005214 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 324057005215 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 324057005216 BNR repeat-like domain; Region: BNR_2; pfam13088 324057005217 Asp-box motif; other site 324057005218 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 324057005219 BNR repeat-like domain; Region: BNR_2; pfam13088 324057005220 Asp-box motif; other site 324057005221 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 324057005222 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 324057005223 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 324057005224 active site 324057005225 non-prolyl cis peptide bond; other site 324057005226 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 324057005227 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 324057005228 Walker A/P-loop; other site 324057005229 ATP binding site [chemical binding]; other site 324057005230 Q-loop/lid; other site 324057005231 ABC transporter signature motif; other site 324057005232 Walker B; other site 324057005233 D-loop; other site 324057005234 H-loop/switch region; other site 324057005235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005236 ABC-ATPase subunit interface; other site 324057005237 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 324057005238 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 324057005239 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057005240 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057005241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005243 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057005244 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057005245 active site 324057005246 catalytic tetrad [active] 324057005247 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 324057005248 catalytic residues [active] 324057005249 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057005250 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057005251 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 324057005252 Methyltransferase domain; Region: Methyltransf_25; pfam13649 324057005253 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 324057005254 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 324057005255 Walker A/P-loop; other site 324057005256 ATP binding site [chemical binding]; other site 324057005257 Q-loop/lid; other site 324057005258 ABC transporter signature motif; other site 324057005259 Walker B; other site 324057005260 D-loop; other site 324057005261 H-loop/switch region; other site 324057005262 FOG: CBS domain [General function prediction only]; Region: COG0517 324057005263 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 324057005264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005265 dimer interface [polypeptide binding]; other site 324057005266 conserved gate region; other site 324057005267 ABC-ATPase subunit interface; other site 324057005268 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 324057005269 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 324057005270 ABC-ATPase subunit interface; other site 324057005271 Phosphotransferase enzyme family; Region: APH; pfam01636 324057005272 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 324057005273 active site 324057005274 ATP binding site [chemical binding]; other site 324057005275 substrate binding site [chemical binding]; other site 324057005276 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057005277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057005278 Coenzyme A binding pocket [chemical binding]; other site 324057005279 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057005280 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 324057005281 NAD(P) binding site [chemical binding]; other site 324057005282 active site 324057005283 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 324057005284 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324057005285 DNA binding residues [nucleotide binding] 324057005286 putative dimer interface [polypeptide binding]; other site 324057005287 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057005288 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 324057005289 Walker A/P-loop; other site 324057005290 ATP binding site [chemical binding]; other site 324057005291 Q-loop/lid; other site 324057005292 ABC transporter signature motif; other site 324057005293 Walker B; other site 324057005294 D-loop; other site 324057005295 H-loop/switch region; other site 324057005296 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057005297 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 324057005298 Walker A/P-loop; other site 324057005299 ATP binding site [chemical binding]; other site 324057005300 Q-loop/lid; other site 324057005301 ABC transporter signature motif; other site 324057005302 Walker B; other site 324057005303 D-loop; other site 324057005304 H-loop/switch region; other site 324057005305 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 324057005306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057005307 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057005308 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057005309 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057005310 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057005311 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 324057005312 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 324057005313 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 324057005314 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 324057005315 Beta-lactamase; Region: Beta-lactamase; pfam00144 324057005316 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 324057005317 active site 324057005318 catalytic residues [active] 324057005319 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057005320 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057005321 DNA binding site [nucleotide binding] 324057005322 domain linker motif; other site 324057005323 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057005324 dimerization interface [polypeptide binding]; other site 324057005325 ligand binding site [chemical binding]; other site 324057005326 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057005327 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005329 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 324057005330 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 324057005331 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057005332 dockerin binding interface; other site 324057005333 S-layer homology domain; Region: SLH; pfam00395 324057005334 S-layer homology domain; Region: SLH; pfam00395 324057005335 S-layer homology domain; Region: SLH; pfam00395 324057005336 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057005337 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057005338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005339 dimer interface [polypeptide binding]; other site 324057005340 conserved gate region; other site 324057005341 putative PBP binding loops; other site 324057005342 ABC-ATPase subunit interface; other site 324057005343 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005345 dimer interface [polypeptide binding]; other site 324057005346 conserved gate region; other site 324057005347 putative PBP binding loops; other site 324057005348 ABC-ATPase subunit interface; other site 324057005349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057005350 Response regulator receiver domain; Region: Response_reg; pfam00072 324057005351 active site 324057005352 phosphorylation site [posttranslational modification] 324057005353 intermolecular recognition site; other site 324057005354 dimerization interface [polypeptide binding]; other site 324057005355 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005356 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005357 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057005358 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057005359 dimerization interface [polypeptide binding]; other site 324057005360 Histidine kinase; Region: His_kinase; pfam06580 324057005361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057005362 ATP binding site [chemical binding]; other site 324057005363 Mg2+ binding site [ion binding]; other site 324057005364 G-X-G motif; other site 324057005365 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057005366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005367 dimer interface [polypeptide binding]; other site 324057005368 conserved gate region; other site 324057005369 putative PBP binding loops; other site 324057005370 ABC-ATPase subunit interface; other site 324057005371 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005373 dimer interface [polypeptide binding]; other site 324057005374 conserved gate region; other site 324057005375 putative PBP binding loops; other site 324057005376 ABC-ATPase subunit interface; other site 324057005377 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057005378 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057005379 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 324057005380 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 324057005381 putative active site [active] 324057005382 putative catalytic site [active] 324057005383 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 324057005384 AAA ATPase domain; Region: AAA_16; pfam13191 324057005385 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057005386 DNA binding residues [nucleotide binding] 324057005387 dimerization interface [polypeptide binding]; other site 324057005388 Small acid-soluble spore protein H family; Region: SspH; pfam08141 324057005389 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 324057005390 Trehalase; Region: Trehalase; cl17346 324057005391 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057005392 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057005393 dimerization interface [polypeptide binding]; other site 324057005394 Histidine kinase; Region: His_kinase; pfam06580 324057005395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057005396 ATP binding site [chemical binding]; other site 324057005397 Mg2+ binding site [ion binding]; other site 324057005398 G-X-G motif; other site 324057005399 Response regulator receiver domain; Region: Response_reg; pfam00072 324057005400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057005401 active site 324057005402 phosphorylation site [posttranslational modification] 324057005403 intermolecular recognition site; other site 324057005404 dimerization interface [polypeptide binding]; other site 324057005405 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005406 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005407 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005408 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057005409 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057005410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005411 dimer interface [polypeptide binding]; other site 324057005412 conserved gate region; other site 324057005413 ABC-ATPase subunit interface; other site 324057005414 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005416 dimer interface [polypeptide binding]; other site 324057005417 conserved gate region; other site 324057005418 putative PBP binding loops; other site 324057005419 ABC-ATPase subunit interface; other site 324057005420 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 324057005421 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324057005422 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057005423 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 324057005424 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 324057005425 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057005426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057005427 putative substrate translocation pore; other site 324057005428 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057005429 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005430 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057005431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005432 dimer interface [polypeptide binding]; other site 324057005433 conserved gate region; other site 324057005434 ABC-ATPase subunit interface; other site 324057005435 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005437 dimer interface [polypeptide binding]; other site 324057005438 conserved gate region; other site 324057005439 putative PBP binding loops; other site 324057005440 ABC-ATPase subunit interface; other site 324057005441 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057005442 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057005443 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 324057005444 active site 324057005445 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 324057005446 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 324057005447 DNA binding residues [nucleotide binding] 324057005448 putative dimer interface [polypeptide binding]; other site 324057005449 short chain dehydrogenase; Provisional; Region: PRK06180 324057005450 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 324057005451 NADP binding site [chemical binding]; other site 324057005452 active site 324057005453 steroid binding site; other site 324057005454 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 324057005455 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 324057005456 classical (c) SDRs; Region: SDR_c; cd05233 324057005457 NAD(P) binding site [chemical binding]; other site 324057005458 active site 324057005459 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057005460 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057005461 DNA binding site [nucleotide binding] 324057005462 domain linker motif; other site 324057005463 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 324057005464 putative dimerization interface [polypeptide binding]; other site 324057005465 putative ligand binding site [chemical binding]; other site 324057005466 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057005467 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 324057005468 active site 324057005469 motif I; other site 324057005470 motif II; other site 324057005471 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057005472 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057005473 dimerization interface [polypeptide binding]; other site 324057005474 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057005475 dimer interface [polypeptide binding]; other site 324057005476 phosphorylation site [posttranslational modification] 324057005477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057005478 ATP binding site [chemical binding]; other site 324057005479 Mg2+ binding site [ion binding]; other site 324057005480 G-X-G motif; other site 324057005481 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057005482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057005483 active site 324057005484 phosphorylation site [posttranslational modification] 324057005485 intermolecular recognition site; other site 324057005486 dimerization interface [polypeptide binding]; other site 324057005487 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057005488 DNA binding site [nucleotide binding] 324057005489 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 324057005490 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 324057005491 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 324057005492 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 324057005493 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 324057005494 Protein export membrane protein; Region: SecD_SecF; cl14618 324057005495 Protein export membrane protein; Region: SecD_SecF; cl14618 324057005496 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 324057005497 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057005498 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057005499 DNA binding residues [nucleotide binding] 324057005500 Putative zinc-finger; Region: zf-HC2; pfam13490 324057005501 Sulfatase; Region: Sulfatase; cl17466 324057005502 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 324057005503 glutamate dehydrogenase; Provisional; Region: PRK09414 324057005504 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 324057005505 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 324057005506 NAD(P) binding site [chemical binding]; other site 324057005507 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057005508 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057005509 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 324057005510 putative dimerization interface [polypeptide binding]; other site 324057005511 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057005512 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057005513 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057005514 Spore germination protein; Region: Spore_permease; cl17796 324057005515 Putative motility protein; Region: YjfB_motility; pfam14070 324057005516 DoxX-like family; Region: DoxX_2; pfam13564 324057005517 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 324057005518 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 324057005519 substrate binding pocket [chemical binding]; other site 324057005520 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 324057005521 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 324057005522 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 324057005523 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 324057005524 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324057005525 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 324057005526 Walker A/P-loop; other site 324057005527 ATP binding site [chemical binding]; other site 324057005528 Q-loop/lid; other site 324057005529 ABC transporter signature motif; other site 324057005530 Walker B; other site 324057005531 D-loop; other site 324057005532 H-loop/switch region; other site 324057005533 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057005534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005535 dimer interface [polypeptide binding]; other site 324057005536 conserved gate region; other site 324057005537 putative PBP binding loops; other site 324057005538 ABC-ATPase subunit interface; other site 324057005539 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 324057005540 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 324057005541 active site 324057005542 non-prolyl cis peptide bond; other site 324057005543 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 324057005544 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 324057005545 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 324057005546 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 324057005547 active site 324057005548 non-prolyl cis peptide bond; other site 324057005549 short chain dehydrogenase; Provisional; Region: PRK08303 324057005550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057005551 NAD(P) binding site [chemical binding]; other site 324057005552 active site 324057005553 Predicted transcriptional regulator [Transcription]; Region: COG2378 324057005554 HTH domain; Region: HTH_11; pfam08279 324057005555 WYL domain; Region: WYL; pfam13280 324057005556 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 324057005557 active site 324057005558 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 324057005559 Ca binding site [ion binding]; other site 324057005560 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 324057005561 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 324057005562 dimer interface [polypeptide binding]; other site 324057005563 active site 324057005564 heme binding site [chemical binding]; other site 324057005565 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 324057005566 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005567 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005568 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057005569 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057005570 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057005571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005572 dimer interface [polypeptide binding]; other site 324057005573 conserved gate region; other site 324057005574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057005575 ABC-ATPase subunit interface; other site 324057005576 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005578 putative PBP binding loops; other site 324057005579 ABC-ATPase subunit interface; other site 324057005580 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057005581 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 324057005582 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 324057005583 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 324057005584 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 324057005585 MgtC family; Region: MgtC; pfam02308 324057005586 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057005587 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057005588 VanZ like family; Region: VanZ; pfam04892 324057005589 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 324057005590 heme-binding site [chemical binding]; other site 324057005591 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 324057005592 heme-binding site [chemical binding]; other site 324057005593 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 324057005594 heme-binding site [chemical binding]; other site 324057005595 S-layer homology domain; Region: SLH; pfam00395 324057005596 S-layer homology domain; Region: SLH; pfam00395 324057005597 S-layer homology domain; Region: SLH; pfam00395 324057005598 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 324057005599 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 324057005600 heme-binding site [chemical binding]; other site 324057005601 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057005602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057005603 active site 324057005604 phosphorylation site [posttranslational modification] 324057005605 intermolecular recognition site; other site 324057005606 dimerization interface [polypeptide binding]; other site 324057005607 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057005608 DNA binding site [nucleotide binding] 324057005609 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 324057005610 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057005611 dimerization interface [polypeptide binding]; other site 324057005612 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057005613 dimer interface [polypeptide binding]; other site 324057005614 phosphorylation site [posttranslational modification] 324057005615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057005616 ATP binding site [chemical binding]; other site 324057005617 Mg2+ binding site [ion binding]; other site 324057005618 G-X-G motif; other site 324057005619 KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592 324057005620 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 324057005621 putative active site [active] 324057005622 putative catalytic site [active] 324057005623 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057005624 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005625 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005626 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005627 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057005628 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057005629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005630 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 324057005631 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 324057005632 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 324057005633 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 324057005634 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005635 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005636 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057005637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005638 dimer interface [polypeptide binding]; other site 324057005639 conserved gate region; other site 324057005640 putative PBP binding loops; other site 324057005641 ABC-ATPase subunit interface; other site 324057005642 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005644 dimer interface [polypeptide binding]; other site 324057005645 conserved gate region; other site 324057005646 ABC-ATPase subunit interface; other site 324057005647 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057005648 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 324057005649 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 324057005650 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 324057005651 MarR family; Region: MarR_2; cl17246 324057005652 Helix-turn-helix domain; Region: HTH_18; pfam12833 324057005653 haloalkane dehalogenase; Provisional; Region: PRK03592 324057005654 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057005655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005656 dimer interface [polypeptide binding]; other site 324057005657 conserved gate region; other site 324057005658 ABC-ATPase subunit interface; other site 324057005659 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005661 dimer interface [polypeptide binding]; other site 324057005662 conserved gate region; other site 324057005663 putative PBP binding loops; other site 324057005664 ABC-ATPase subunit interface; other site 324057005665 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057005666 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057005667 Response regulator receiver domain; Region: Response_reg; pfam00072 324057005668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057005669 active site 324057005670 phosphorylation site [posttranslational modification] 324057005671 intermolecular recognition site; other site 324057005672 dimerization interface [polypeptide binding]; other site 324057005673 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005674 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005675 Histidine kinase; Region: His_kinase; pfam06580 324057005676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057005677 ATP binding site [chemical binding]; other site 324057005678 Mg2+ binding site [ion binding]; other site 324057005679 G-X-G motif; other site 324057005680 alpha-glucosidase; Provisional; Region: PRK10137 324057005681 Cupin domain; Region: Cupin_2; pfam07883 324057005682 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005683 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005684 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057005685 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057005686 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057005687 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057005688 active site 324057005689 catalytic tetrad [active] 324057005690 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057005691 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057005692 dimerization interface [polypeptide binding]; other site 324057005693 Histidine kinase; Region: His_kinase; pfam06580 324057005694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057005695 ATP binding site [chemical binding]; other site 324057005696 Mg2+ binding site [ion binding]; other site 324057005697 G-X-G motif; other site 324057005698 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 324057005699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057005700 active site 324057005701 phosphorylation site [posttranslational modification] 324057005702 intermolecular recognition site; other site 324057005703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005704 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005706 carbohydrate ABC transporter substrate-binding protein, CPR_0540 family; Region: bind_CPR_0540; TIGR03850 324057005707 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057005708 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057005709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005710 dimer interface [polypeptide binding]; other site 324057005711 conserved gate region; other site 324057005712 putative PBP binding loops; other site 324057005713 ABC-ATPase subunit interface; other site 324057005714 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005716 dimer interface [polypeptide binding]; other site 324057005717 conserved gate region; other site 324057005718 putative PBP binding loops; other site 324057005719 ABC-ATPase subunit interface; other site 324057005720 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 324057005721 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 324057005722 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057005723 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 324057005724 Cupin domain; Region: Cupin_2; pfam07883 324057005725 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005726 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005728 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 324057005729 active site 324057005730 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057005731 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057005732 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057005733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005734 dimer interface [polypeptide binding]; other site 324057005735 conserved gate region; other site 324057005736 ABC-ATPase subunit interface; other site 324057005737 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005739 dimer interface [polypeptide binding]; other site 324057005740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057005741 ABC-ATPase subunit interface; other site 324057005742 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324057005743 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057005744 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 324057005745 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 324057005746 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 324057005747 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057005748 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057005749 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 324057005750 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057005751 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 324057005752 active site 324057005753 substrate binding site [chemical binding]; other site 324057005754 ATP binding site [chemical binding]; other site 324057005755 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 324057005756 Flavodoxin; Region: Flavodoxin_1; pfam00258 324057005757 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 324057005758 FAD binding pocket [chemical binding]; other site 324057005759 FAD binding motif [chemical binding]; other site 324057005760 catalytic residues [active] 324057005761 NAD binding pocket [chemical binding]; other site 324057005762 phosphate binding motif [ion binding]; other site 324057005763 beta-alpha-beta structure motif; other site 324057005764 sulfite reductase subunit beta; Provisional; Region: PRK13504 324057005765 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 324057005766 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 324057005767 MarR family; Region: MarR_2; cl17246 324057005768 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324057005769 ROK family; Region: ROK; pfam00480 324057005770 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 324057005771 D-mannonate oxidoreductase; Provisional; Region: PRK08277 324057005772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057005773 NAD(P) binding site [chemical binding]; other site 324057005774 active site 324057005775 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 324057005776 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 324057005777 Ligand Binding Site [chemical binding]; other site 324057005778 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 324057005779 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 324057005780 N- and C-terminal domain interface [polypeptide binding]; other site 324057005781 active site 324057005782 catalytic site [active] 324057005783 metal binding site [ion binding]; metal-binding site 324057005784 carbohydrate binding site [chemical binding]; other site 324057005785 ATP binding site [chemical binding]; other site 324057005786 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 324057005787 AIR carboxylase; Region: AIRC; smart01001 324057005788 High-affinity nickel-transport protein; Region: NicO; cl00964 324057005789 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057005790 Interdomain contacts; other site 324057005791 Cytokine receptor motif; other site 324057005792 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057005793 Interdomain contacts; other site 324057005794 Cytokine receptor motif; other site 324057005795 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 324057005796 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 324057005797 active site 324057005798 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057005799 Interdomain contacts; other site 324057005800 Cytokine receptor motif; other site 324057005801 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057005802 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 324057005803 Walker A/P-loop; other site 324057005804 ATP binding site [chemical binding]; other site 324057005805 Q-loop/lid; other site 324057005806 ABC transporter signature motif; other site 324057005807 Walker B; other site 324057005808 D-loop; other site 324057005809 H-loop/switch region; other site 324057005810 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 324057005811 ABC-2 type transporter; Region: ABC2_membrane; cl17235 324057005812 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 324057005813 hypothetical protein; Provisional; Region: PRK07236 324057005814 FAD binding domain; Region: FAD_binding_3; pfam01494 324057005815 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 324057005816 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005817 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005818 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005819 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057005820 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057005821 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057005822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005823 dimer interface [polypeptide binding]; other site 324057005824 conserved gate region; other site 324057005825 ABC-ATPase subunit interface; other site 324057005826 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005828 dimer interface [polypeptide binding]; other site 324057005829 conserved gate region; other site 324057005830 putative PBP binding loops; other site 324057005831 ABC-ATPase subunit interface; other site 324057005832 Predicted transcriptional regulators [Transcription]; Region: COG1733 324057005833 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 324057005834 MFS transport protein AraJ; Provisional; Region: PRK10091 324057005835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057005836 putative substrate translocation pore; other site 324057005837 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057005838 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005839 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057005840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005841 dimer interface [polypeptide binding]; other site 324057005842 conserved gate region; other site 324057005843 ABC-ATPase subunit interface; other site 324057005844 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057005845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005846 dimer interface [polypeptide binding]; other site 324057005847 conserved gate region; other site 324057005848 putative PBP binding loops; other site 324057005849 ABC-ATPase subunit interface; other site 324057005850 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057005851 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 324057005852 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 324057005853 Walker A/P-loop; other site 324057005854 ATP binding site [chemical binding]; other site 324057005855 Q-loop/lid; other site 324057005856 ABC transporter signature motif; other site 324057005857 Walker B; other site 324057005858 D-loop; other site 324057005859 H-loop/switch region; other site 324057005860 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 324057005861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005862 dimer interface [polypeptide binding]; other site 324057005863 conserved gate region; other site 324057005864 putative PBP binding loops; other site 324057005865 ABC-ATPase subunit interface; other site 324057005866 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 324057005867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057005868 dimer interface [polypeptide binding]; other site 324057005869 conserved gate region; other site 324057005870 putative PBP binding loops; other site 324057005871 ABC-ATPase subunit interface; other site 324057005872 PBP superfamily domain; Region: PBP_like_2; cl17296 324057005873 acetylornithine deacetylase; Validated; Region: PRK08596 324057005874 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 324057005875 metal binding site [ion binding]; metal-binding site 324057005876 DinB family; Region: DinB; cl17821 324057005877 DinB superfamily; Region: DinB_2; pfam12867 324057005878 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057005879 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057005880 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 324057005881 ABC-2 type transporter; Region: ABC2_membrane; cl17235 324057005882 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 324057005883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057005884 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 324057005885 Walker A/P-loop; other site 324057005886 ATP binding site [chemical binding]; other site 324057005887 Q-loop/lid; other site 324057005888 ABC transporter signature motif; other site 324057005889 Walker B; other site 324057005890 D-loop; other site 324057005891 H-loop/switch region; other site 324057005892 YtxH-like protein; Region: YtxH; pfam12732 324057005893 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 324057005894 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057005895 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 324057005896 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057005897 DNA binding residues [nucleotide binding] 324057005898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057005899 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 324057005900 ATP binding site [chemical binding]; other site 324057005901 Mg2+ binding site [ion binding]; other site 324057005902 G-X-G motif; other site 324057005903 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 324057005904 CHASE3 domain; Region: CHASE3; pfam05227 324057005905 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057005906 dimerization interface [polypeptide binding]; other site 324057005907 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 324057005908 GAF domain; Region: GAF; pfam01590 324057005909 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057005910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057005911 dimer interface [polypeptide binding]; other site 324057005912 phosphorylation site [posttranslational modification] 324057005913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057005914 ATP binding site [chemical binding]; other site 324057005915 Mg2+ binding site [ion binding]; other site 324057005916 G-X-G motif; other site 324057005917 Response regulator receiver domain; Region: Response_reg; pfam00072 324057005918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057005919 active site 324057005920 phosphorylation site [posttranslational modification] 324057005921 intermolecular recognition site; other site 324057005922 dimerization interface [polypeptide binding]; other site 324057005923 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 324057005924 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 324057005925 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324057005926 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 324057005927 nucleotide binding site [chemical binding]; other site 324057005928 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 324057005929 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 324057005930 N- and C-terminal domain interface [polypeptide binding]; other site 324057005931 D-xylulose kinase; Region: XylB; TIGR01312 324057005932 active site 324057005933 MgATP binding site [chemical binding]; other site 324057005934 catalytic site [active] 324057005935 metal binding site [ion binding]; metal-binding site 324057005936 xylulose binding site [chemical binding]; other site 324057005937 homodimer interface [polypeptide binding]; other site 324057005938 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 324057005939 active site 324057005940 Predicted transcriptional regulator [Transcription]; Region: COG2378 324057005941 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 324057005942 WYL domain; Region: WYL; pfam13280 324057005943 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 324057005944 Dynamin family; Region: Dynamin_N; pfam00350 324057005945 G1 box; other site 324057005946 GTP/Mg2+ binding site [chemical binding]; other site 324057005947 G2 box; other site 324057005948 Switch I region; other site 324057005949 G3 box; other site 324057005950 Switch II region; other site 324057005951 G4 box; other site 324057005952 G5 box; other site 324057005953 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 324057005954 Dynamin family; Region: Dynamin_N; pfam00350 324057005955 G1 box; other site 324057005956 GTP/Mg2+ binding site [chemical binding]; other site 324057005957 G2 box; other site 324057005958 Switch I region; other site 324057005959 G3 box; other site 324057005960 Switch II region; other site 324057005961 G4 box; other site 324057005962 G5 box; other site 324057005963 Domain of unknown function DUF87; Region: DUF87; pfam01935 324057005964 AAA-like domain; Region: AAA_10; pfam12846 324057005965 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 324057005966 active site 324057005967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 324057005968 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005969 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057005970 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057005971 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057005972 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 324057005973 active site 324057005974 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 324057005975 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 324057005976 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 324057005977 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 324057005978 Cohesin domain, interaction parter of dockerin; Region: cohesin_like; cd08546 324057005979 dockerin binding interface; other site 324057005980 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057005981 dockerin binding interface; other site 324057005982 S-layer homology domain; Region: SLH; pfam00395 324057005983 S-layer homology domain; Region: SLH; pfam00395 324057005984 S-layer homology domain; Region: SLH; pfam00395 324057005985 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 324057005986 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057005987 ligand binding site [chemical binding]; other site 324057005988 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057005989 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057005990 dimerization interface [polypeptide binding]; other site 324057005991 Histidine kinase; Region: His_kinase; pfam06580 324057005992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057005993 ATP binding site [chemical binding]; other site 324057005994 Mg2+ binding site [ion binding]; other site 324057005995 G-X-G motif; other site 324057005996 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057005997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057005998 active site 324057005999 phosphorylation site [posttranslational modification] 324057006000 intermolecular recognition site; other site 324057006001 dimerization interface [polypeptide binding]; other site 324057006002 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006003 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057006004 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057006005 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 324057006006 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 324057006007 ligand binding site [chemical binding]; other site 324057006008 calcium binding site [ion binding]; other site 324057006009 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 324057006010 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 324057006011 Walker A/P-loop; other site 324057006012 ATP binding site [chemical binding]; other site 324057006013 Q-loop/lid; other site 324057006014 ABC transporter signature motif; other site 324057006015 Walker B; other site 324057006016 D-loop; other site 324057006017 H-loop/switch region; other site 324057006018 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 324057006019 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 324057006020 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 324057006021 TM-ABC transporter signature motif; other site 324057006022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057006023 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 324057006024 ATP binding site [chemical binding]; other site 324057006025 Mg2+ binding site [ion binding]; other site 324057006026 G-X-G motif; other site 324057006027 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 324057006028 anti sigma factor interaction site; other site 324057006029 regulatory phosphorylation site [posttranslational modification]; other site 324057006030 Response regulator receiver domain; Region: Response_reg; pfam00072 324057006031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057006032 active site 324057006033 phosphorylation site [posttranslational modification] 324057006034 intermolecular recognition site; other site 324057006035 dimerization interface [polypeptide binding]; other site 324057006036 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 324057006037 Heat induced stress protein YflT; Region: YflT; pfam11181 324057006038 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 324057006039 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 324057006040 active site 324057006041 catalytic site [active] 324057006042 metal binding site [ion binding]; metal-binding site 324057006043 dimer interface [polypeptide binding]; other site 324057006044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006045 dimer interface [polypeptide binding]; other site 324057006046 conserved gate region; other site 324057006047 putative PBP binding loops; other site 324057006048 ABC-ATPase subunit interface; other site 324057006049 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057006050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006051 dimer interface [polypeptide binding]; other site 324057006052 conserved gate region; other site 324057006053 putative PBP binding loops; other site 324057006054 ABC-ATPase subunit interface; other site 324057006055 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 324057006056 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057006057 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 324057006058 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 324057006059 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 324057006060 dimer interface [polypeptide binding]; other site 324057006061 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057006062 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 324057006063 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 324057006064 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 324057006065 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 324057006066 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 324057006067 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 324057006068 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 324057006069 Amidohydrolase; Region: Amidohydro_5; pfam13594 324057006070 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 324057006071 active site 324057006072 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 324057006073 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324057006074 catalytic core [active] 324057006075 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324057006076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057006077 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057006078 putative substrate translocation pore; other site 324057006079 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 324057006080 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 324057006081 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057006082 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057006083 DNA binding residues [nucleotide binding] 324057006084 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057006085 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057006086 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057006087 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057006088 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057006089 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057006090 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057006091 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006092 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006093 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057006094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006095 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057006096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057006097 putative substrate translocation pore; other site 324057006098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057006099 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 324057006100 AAA domain; Region: AAA_18; pfam13238 324057006101 ATP-binding site [chemical binding]; other site 324057006102 Sugar specificity; other site 324057006103 Pyrimidine base specificity; other site 324057006104 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 324057006105 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 324057006106 N- and C-terminal domain interface [polypeptide binding]; other site 324057006107 active site 324057006108 MgATP binding site [chemical binding]; other site 324057006109 catalytic site [active] 324057006110 metal binding site [ion binding]; metal-binding site 324057006111 xylulose binding site [chemical binding]; other site 324057006112 putative homodimer interface [polypeptide binding]; other site 324057006113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057006114 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057006115 putative substrate translocation pore; other site 324057006116 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 324057006117 intersubunit interface [polypeptide binding]; other site 324057006118 active site 324057006119 Zn2+ binding site [ion binding]; other site 324057006120 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 324057006121 Zn2+ binding site [ion binding]; other site 324057006122 intersubunit interface [polypeptide binding]; other site 324057006123 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 324057006124 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 324057006125 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057006126 catalytic residue [active] 324057006127 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 324057006128 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 324057006129 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 324057006130 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057006131 active site 324057006132 metal binding site [ion binding]; metal-binding site 324057006133 hexamer interface [polypeptide binding]; other site 324057006134 Transcriptional regulators [Transcription]; Region: FadR; COG2186 324057006135 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057006136 DNA-binding site [nucleotide binding]; DNA binding site 324057006137 FCD domain; Region: FCD; pfam07729 324057006138 Predicted transcriptional regulators [Transcription]; Region: COG1725 324057006139 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057006140 DNA-binding site [nucleotide binding]; DNA binding site 324057006141 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 324057006142 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 324057006143 Walker A/P-loop; other site 324057006144 ATP binding site [chemical binding]; other site 324057006145 Q-loop/lid; other site 324057006146 ABC transporter signature motif; other site 324057006147 Walker B; other site 324057006148 D-loop; other site 324057006149 H-loop/switch region; other site 324057006150 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 324057006151 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 324057006152 AsnC family; Region: AsnC_trans_reg; pfam01037 324057006153 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 324057006154 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 324057006155 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 324057006156 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 324057006157 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 324057006158 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 324057006159 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 324057006160 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057006161 ATP binding site [chemical binding]; other site 324057006162 putative Mg++ binding site [ion binding]; other site 324057006163 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057006164 nucleotide binding region [chemical binding]; other site 324057006165 ATP-binding site [chemical binding]; other site 324057006166 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057006167 MarR family; Region: MarR; pfam01047 324057006168 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 324057006169 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 324057006170 putative NAD(P) binding site [chemical binding]; other site 324057006171 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 324057006172 substrate binding site [chemical binding]; other site 324057006173 active site 324057006174 BclB C-terminal domain; Region: exospore_TM; TIGR03721 324057006175 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 324057006176 putative metal binding site; other site 324057006177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057006178 binding surface 324057006179 TPR motif; other site 324057006180 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057006181 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057006182 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006183 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006184 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 324057006185 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057006186 MarR family; Region: MarR_2; pfam12802 324057006187 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057006188 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324057006189 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 324057006190 Walker A/P-loop; other site 324057006191 ATP binding site [chemical binding]; other site 324057006192 Q-loop/lid; other site 324057006193 ABC transporter signature motif; other site 324057006194 Walker B; other site 324057006195 D-loop; other site 324057006196 H-loop/switch region; other site 324057006197 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 324057006198 short chain dehydrogenase; Provisional; Region: PRK06701 324057006199 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 324057006200 NAD binding site [chemical binding]; other site 324057006201 metal binding site [ion binding]; metal-binding site 324057006202 active site 324057006203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057006204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057006205 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 324057006206 putative dimerization interface [polypeptide binding]; other site 324057006207 holin-like protein; Validated; Region: PRK01658 324057006208 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 324057006209 EamA-like transporter family; Region: EamA; pfam00892 324057006210 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324057006211 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057006212 non-specific DNA binding site [nucleotide binding]; other site 324057006213 salt bridge; other site 324057006214 sequence-specific DNA binding site [nucleotide binding]; other site 324057006215 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 324057006216 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324057006217 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 324057006218 active site 324057006219 NTP binding site [chemical binding]; other site 324057006220 metal binding triad [ion binding]; metal-binding site 324057006221 antibiotic binding site [chemical binding]; other site 324057006222 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 324057006223 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 324057006224 active site 324057006225 HIGH motif; other site 324057006226 dimer interface [polypeptide binding]; other site 324057006227 KMSKS motif; other site 324057006228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 324057006229 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 324057006230 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 324057006231 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 324057006232 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057006233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006234 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057006235 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006236 putative alpha-glucosidase; Provisional; Region: PRK10658 324057006237 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 324057006238 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 324057006239 active site 324057006240 homotrimer interface [polypeptide binding]; other site 324057006241 catalytic site [active] 324057006242 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 324057006243 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 324057006244 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 324057006245 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 324057006246 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057006247 ligand binding site [chemical binding]; other site 324057006248 metal binding site [ion binding]; metal-binding site 324057006249 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057006250 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057006251 dimerization interface [polypeptide binding]; other site 324057006252 Histidine kinase; Region: His_kinase; pfam06580 324057006253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057006254 ATP binding site [chemical binding]; other site 324057006255 Mg2+ binding site [ion binding]; other site 324057006256 G-X-G motif; other site 324057006257 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057006258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057006259 active site 324057006260 phosphorylation site [posttranslational modification] 324057006261 intermolecular recognition site; other site 324057006262 dimerization interface [polypeptide binding]; other site 324057006263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006264 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006265 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057006266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006267 dimer interface [polypeptide binding]; other site 324057006268 conserved gate region; other site 324057006269 ABC-ATPase subunit interface; other site 324057006270 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057006271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006272 dimer interface [polypeptide binding]; other site 324057006273 conserved gate region; other site 324057006274 ABC-ATPase subunit interface; other site 324057006275 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057006276 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057006277 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 324057006278 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057006279 dimerization interface [polypeptide binding]; other site 324057006280 Histidine kinase; Region: His_kinase; pfam06580 324057006281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057006282 ATP binding site [chemical binding]; other site 324057006283 Mg2+ binding site [ion binding]; other site 324057006284 G-X-G motif; other site 324057006285 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 324057006286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057006287 active site 324057006288 phosphorylation site [posttranslational modification] 324057006289 intermolecular recognition site; other site 324057006290 dimerization interface [polypeptide binding]; other site 324057006291 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057006292 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006293 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057006294 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057006295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006296 dimer interface [polypeptide binding]; other site 324057006297 conserved gate region; other site 324057006298 ABC-ATPase subunit interface; other site 324057006299 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057006300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006301 dimer interface [polypeptide binding]; other site 324057006302 conserved gate region; other site 324057006303 putative PBP binding loops; other site 324057006304 ABC-ATPase subunit interface; other site 324057006305 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 324057006306 putative transposase OrfB; Reviewed; Region: PHA02517 324057006307 HTH-like domain; Region: HTH_21; pfam13276 324057006308 Integrase core domain; Region: rve; pfam00665 324057006309 Integrase core domain; Region: rve_3; pfam13683 324057006310 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 324057006311 Transposase; Region: HTH_Tnp_1; cl17663 324057006312 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 324057006313 dimer interface [polypeptide binding]; other site 324057006314 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057006315 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 324057006316 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 324057006317 PYR/PP interface [polypeptide binding]; other site 324057006318 dimer interface [polypeptide binding]; other site 324057006319 TPP binding site [chemical binding]; other site 324057006320 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 324057006321 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 324057006322 TPP-binding site; other site 324057006323 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057006324 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 324057006325 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 324057006326 substrate binding site [chemical binding]; other site 324057006327 ATP binding site [chemical binding]; other site 324057006328 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 324057006329 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 324057006330 tetrameric interface [polypeptide binding]; other site 324057006331 NAD binding site [chemical binding]; other site 324057006332 catalytic residues [active] 324057006333 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057006334 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057006335 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057006336 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 324057006337 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057006338 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057006339 DNA binding site [nucleotide binding] 324057006340 domain linker motif; other site 324057006341 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057006342 dimerization interface [polypeptide binding]; other site 324057006343 ligand binding site [chemical binding]; other site 324057006344 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 324057006345 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057006346 DNA-binding site [nucleotide binding]; DNA binding site 324057006347 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057006348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057006349 homodimer interface [polypeptide binding]; other site 324057006350 catalytic residue [active] 324057006351 Rrf2 family protein; Region: rrf2_super; TIGR00738 324057006352 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057006353 putative Zn2+ binding site [ion binding]; other site 324057006354 putative DNA binding site [nucleotide binding]; other site 324057006355 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 324057006356 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 324057006357 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 324057006358 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 324057006359 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 324057006360 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057006361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057006362 NAD(P) binding site [chemical binding]; other site 324057006363 active site 324057006364 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057006365 Interdomain contacts; other site 324057006366 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057006367 sugar binding site [chemical binding]; other site 324057006368 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 324057006369 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 324057006370 S-layer homology domain; Region: SLH; pfam00395 324057006371 S-layer homology domain; Region: SLH; pfam00395 324057006372 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 324057006373 hydrophobic ligand binding site; other site 324057006374 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 324057006375 GIY-YIG motif/motif A; other site 324057006376 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057006377 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057006378 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057006379 Spore germination protein; Region: Spore_permease; cl17796 324057006380 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 324057006381 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 324057006382 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 324057006383 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057006384 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 324057006385 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 324057006386 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 324057006387 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057006388 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057006389 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057006390 dimerization interface [polypeptide binding]; other site 324057006391 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 324057006392 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 324057006393 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 324057006394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006395 dimer interface [polypeptide binding]; other site 324057006396 conserved gate region; other site 324057006397 putative PBP binding loops; other site 324057006398 ABC-ATPase subunit interface; other site 324057006399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006400 dimer interface [polypeptide binding]; other site 324057006401 conserved gate region; other site 324057006402 ABC-ATPase subunit interface; other site 324057006403 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 324057006404 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 324057006405 Walker A/P-loop; other site 324057006406 ATP binding site [chemical binding]; other site 324057006407 Q-loop/lid; other site 324057006408 ABC transporter signature motif; other site 324057006409 Walker B; other site 324057006410 D-loop; other site 324057006411 H-loop/switch region; other site 324057006412 Cupin; Region: Cupin_1; smart00835 324057006413 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 324057006414 Cupin; Region: Cupin_1; smart00835 324057006415 Cupin; Region: Cupin_1; smart00835 324057006416 Pirin-related protein [General function prediction only]; Region: COG1741 324057006417 Pirin; Region: Pirin; pfam02678 324057006418 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 324057006419 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 324057006420 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 324057006421 active site 324057006422 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057006423 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006424 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 324057006425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 324057006426 Cache domain; Region: Cache_1; pfam02743 324057006427 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057006428 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057006429 dimerization interface [polypeptide binding]; other site 324057006430 Histidine kinase; Region: His_kinase; pfam06580 324057006431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057006432 ATP binding site [chemical binding]; other site 324057006433 Mg2+ binding site [ion binding]; other site 324057006434 G-X-G motif; other site 324057006435 Response regulator receiver domain; Region: Response_reg; pfam00072 324057006436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057006437 active site 324057006438 phosphorylation site [posttranslational modification] 324057006439 intermolecular recognition site; other site 324057006440 dimerization interface [polypeptide binding]; other site 324057006441 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006442 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057006443 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006444 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057006445 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057006446 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057006447 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057006448 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057006449 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057006450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006451 dimer interface [polypeptide binding]; other site 324057006452 conserved gate region; other site 324057006453 ABC-ATPase subunit interface; other site 324057006454 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057006455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006456 dimer interface [polypeptide binding]; other site 324057006457 ABC-ATPase subunit interface; other site 324057006458 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057006459 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057006460 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057006461 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 324057006462 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 324057006463 S-layer homology domain; Region: SLH; pfam00395 324057006464 S-layer homology domain; Region: SLH; pfam00395 324057006465 Abhydrolase family; Region: Abhydrolase_7; pfam12715 324057006466 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324057006467 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057006468 dockerin binding interface; other site 324057006469 S-layer homology domain; Region: SLH; pfam00395 324057006470 S-layer homology domain; Region: SLH; pfam00395 324057006471 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 324057006472 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 324057006473 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 324057006474 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057006475 dockerin binding interface; other site 324057006476 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057006477 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057006478 dimerization interface [polypeptide binding]; other site 324057006479 Histidine kinase; Region: His_kinase; pfam06580 324057006480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057006481 ATP binding site [chemical binding]; other site 324057006482 Mg2+ binding site [ion binding]; other site 324057006483 G-X-G motif; other site 324057006484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057006485 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057006486 active site 324057006487 phosphorylation site [posttranslational modification] 324057006488 intermolecular recognition site; other site 324057006489 dimerization interface [polypeptide binding]; other site 324057006490 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006491 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006492 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057006493 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057006494 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057006495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006496 dimer interface [polypeptide binding]; other site 324057006497 conserved gate region; other site 324057006498 putative PBP binding loops; other site 324057006499 ABC-ATPase subunit interface; other site 324057006500 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057006501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006502 dimer interface [polypeptide binding]; other site 324057006503 conserved gate region; other site 324057006504 putative PBP binding loops; other site 324057006505 ABC-ATPase subunit interface; other site 324057006506 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 324057006507 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 324057006508 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 324057006509 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 324057006510 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 324057006511 dimerization domain swap beta strand [polypeptide binding]; other site 324057006512 regulatory protein interface [polypeptide binding]; other site 324057006513 active site 324057006514 regulatory phosphorylation site [posttranslational modification]; other site 324057006515 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 324057006516 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 324057006517 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 324057006518 active site turn [active] 324057006519 phosphorylation site [posttranslational modification] 324057006520 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 324057006521 HPr interaction site; other site 324057006522 glycerol kinase (GK) interaction site [polypeptide binding]; other site 324057006523 active site 324057006524 phosphorylation site [posttranslational modification] 324057006525 transcriptional antiterminator BglG; Provisional; Region: PRK09772 324057006526 CAT RNA binding domain; Region: CAT_RBD; smart01061 324057006527 PRD domain; Region: PRD; pfam00874 324057006528 PRD domain; Region: PRD; pfam00874 324057006529 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 324057006530 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057006531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057006532 NAD(P) binding site [chemical binding]; other site 324057006533 active site 324057006534 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 324057006535 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 324057006536 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 324057006537 EamA-like transporter family; Region: EamA; pfam00892 324057006538 EamA-like transporter family; Region: EamA; pfam00892 324057006539 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057006540 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057006541 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057006542 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 324057006543 nudix motif; other site 324057006544 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 324057006545 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 324057006546 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057006547 active site 324057006548 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057006549 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 324057006550 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057006551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006552 dimer interface [polypeptide binding]; other site 324057006553 conserved gate region; other site 324057006554 putative PBP binding loops; other site 324057006555 ABC-ATPase subunit interface; other site 324057006556 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324057006557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006558 dimer interface [polypeptide binding]; other site 324057006559 conserved gate region; other site 324057006560 putative PBP binding loops; other site 324057006561 ABC-ATPase subunit interface; other site 324057006562 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057006563 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057006564 dimerization interface [polypeptide binding]; other site 324057006565 Histidine kinase; Region: His_kinase; pfam06580 324057006566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057006567 ATP binding site [chemical binding]; other site 324057006568 Mg2+ binding site [ion binding]; other site 324057006569 G-X-G motif; other site 324057006570 Response regulator receiver domain; Region: Response_reg; pfam00072 324057006571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057006572 active site 324057006573 phosphorylation site [posttranslational modification] 324057006574 intermolecular recognition site; other site 324057006575 dimerization interface [polypeptide binding]; other site 324057006576 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006577 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057006578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006579 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 324057006580 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057006581 NAD(P) binding site [chemical binding]; other site 324057006582 active site 324057006583 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 324057006584 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 324057006585 DNA binding residues [nucleotide binding] 324057006586 putative dimer interface [polypeptide binding]; other site 324057006587 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057006588 Coenzyme A binding pocket [chemical binding]; other site 324057006589 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 324057006590 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 324057006591 active site residue [active] 324057006592 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 324057006593 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 324057006594 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 324057006595 active site residue [active] 324057006596 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057006597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057006598 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057006599 dimerization interface [polypeptide binding]; other site 324057006600 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 324057006601 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 324057006602 Tetramer interface [polypeptide binding]; other site 324057006603 active site 324057006604 FMN-binding site [chemical binding]; other site 324057006605 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 324057006606 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 324057006607 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 324057006608 metal binding site [ion binding]; metal-binding site 324057006609 active site 324057006610 aconitate hydratase; Validated; Region: PRK09277 324057006611 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 324057006612 substrate binding site [chemical binding]; other site 324057006613 ligand binding site [chemical binding]; other site 324057006614 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 324057006615 substrate binding site [chemical binding]; other site 324057006616 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 324057006617 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 324057006618 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 324057006619 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 324057006620 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 324057006621 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 324057006622 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 324057006623 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 324057006624 Uncharacterized conserved protein [Function unknown]; Region: COG3937 324057006625 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 324057006626 ABC1 family; Region: ABC1; pfam03109 324057006627 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 324057006628 active site 324057006629 ATP binding site [chemical binding]; other site 324057006630 CotH protein; Region: CotH; pfam08757 324057006631 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 324057006632 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 324057006633 putative metal binding residues [ion binding]; other site 324057006634 signature motif; other site 324057006635 dimer interface [polypeptide binding]; other site 324057006636 active site 324057006637 polyP binding site; other site 324057006638 substrate binding site [chemical binding]; other site 324057006639 acceptor-phosphate pocket; other site 324057006640 HAMP domain; Region: HAMP; pfam00672 324057006641 dimerization interface [polypeptide binding]; other site 324057006642 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057006643 dimer interface [polypeptide binding]; other site 324057006644 phosphorylation site [posttranslational modification] 324057006645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057006646 ATP binding site [chemical binding]; other site 324057006647 Mg2+ binding site [ion binding]; other site 324057006648 G-X-G motif; other site 324057006649 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057006650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057006651 active site 324057006652 phosphorylation site [posttranslational modification] 324057006653 intermolecular recognition site; other site 324057006654 dimerization interface [polypeptide binding]; other site 324057006655 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057006656 DNA binding site [nucleotide binding] 324057006657 metal-dependent hydrolase; Provisional; Region: PRK00685 324057006658 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 324057006659 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 324057006660 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 324057006661 putative metal binding site [ion binding]; other site 324057006662 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 324057006663 active site 324057006664 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057006665 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 324057006666 active site 324057006667 motif I; other site 324057006668 motif II; other site 324057006669 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057006670 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 324057006671 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 324057006672 DHHA2 domain; Region: DHHA2; pfam02833 324057006673 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 324057006674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057006675 Coenzyme A binding pocket [chemical binding]; other site 324057006676 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 324057006677 NlpC/P60 family; Region: NLPC_P60; pfam00877 324057006678 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057006679 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057006680 putative Zn2+ binding site [ion binding]; other site 324057006681 putative DNA binding site [nucleotide binding]; other site 324057006682 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057006683 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324057006684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057006685 Walker A/P-loop; other site 324057006686 ATP binding site [chemical binding]; other site 324057006687 Q-loop/lid; other site 324057006688 ABC transporter signature motif; other site 324057006689 Walker B; other site 324057006690 D-loop; other site 324057006691 H-loop/switch region; other site 324057006692 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324057006693 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 324057006694 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 324057006695 Walker A/P-loop; other site 324057006696 ATP binding site [chemical binding]; other site 324057006697 Q-loop/lid; other site 324057006698 ABC transporter signature motif; other site 324057006699 Walker B; other site 324057006700 D-loop; other site 324057006701 H-loop/switch region; other site 324057006702 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 324057006703 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057006704 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057006705 Coenzyme A binding pocket [chemical binding]; other site 324057006706 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 324057006707 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057006708 motif II; other site 324057006709 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057006710 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057006711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006712 dimer interface [polypeptide binding]; other site 324057006713 conserved gate region; other site 324057006714 putative PBP binding loops; other site 324057006715 ABC-ATPase subunit interface; other site 324057006716 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057006717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006718 dimer interface [polypeptide binding]; other site 324057006719 conserved gate region; other site 324057006720 putative PBP binding loops; other site 324057006721 ABC-ATPase subunit interface; other site 324057006722 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057006723 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057006724 dimerization interface [polypeptide binding]; other site 324057006725 Histidine kinase; Region: His_kinase; pfam06580 324057006726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057006727 ATP binding site [chemical binding]; other site 324057006728 Mg2+ binding site [ion binding]; other site 324057006729 G-X-G motif; other site 324057006730 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057006731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057006732 active site 324057006733 phosphorylation site [posttranslational modification] 324057006734 intermolecular recognition site; other site 324057006735 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006736 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006737 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057006738 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 324057006739 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057006740 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057006741 Coenzyme A binding pocket [chemical binding]; other site 324057006742 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057006743 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057006744 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057006745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006746 dimer interface [polypeptide binding]; other site 324057006747 conserved gate region; other site 324057006748 ABC-ATPase subunit interface; other site 324057006749 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057006750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057006751 dimer interface [polypeptide binding]; other site 324057006752 ABC-ATPase subunit interface; other site 324057006753 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 324057006754 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057006755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057006756 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057006757 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057006758 Holin family; Region: Phage_holin_4; pfam05105 324057006759 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 324057006760 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 324057006761 Uncharacterized conserved protein [Function unknown]; Region: COG2445 324057006762 Predicted transcriptional regulator [Transcription]; Region: COG2345 324057006763 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057006764 putative DNA binding site [nucleotide binding]; other site 324057006765 dimerization interface [polypeptide binding]; other site 324057006766 putative Zn2+ binding site [ion binding]; other site 324057006767 YtxH-like protein; Region: YtxH; pfam12732 324057006768 glutamate racemase; Provisional; Region: PRK00865 324057006769 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057006770 MarR family; Region: MarR; pfam01047 324057006771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057006772 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057006773 putative substrate translocation pore; other site 324057006774 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 324057006775 active site 324057006776 Zn binding site [ion binding]; other site 324057006777 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 324057006778 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 324057006779 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 324057006780 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 324057006781 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 324057006782 Sulfatase; Region: Sulfatase; pfam00884 324057006783 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 324057006784 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 324057006785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 324057006786 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 324057006787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 324057006788 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 324057006789 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 324057006790 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 324057006791 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 324057006792 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 324057006793 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 324057006794 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 324057006795 Walker A motif; other site 324057006796 ATP binding site [chemical binding]; other site 324057006797 Walker B motif; other site 324057006798 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 324057006799 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 324057006800 Walker A motif; other site 324057006801 ATP binding site [chemical binding]; other site 324057006802 Walker B motif; other site 324057006803 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 324057006804 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 324057006805 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 324057006806 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 324057006807 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 324057006808 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 324057006809 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 324057006810 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 324057006811 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 324057006812 substrate binding site [chemical binding]; other site 324057006813 active site 324057006814 ferrochelatase; Provisional; Region: PRK12435 324057006815 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 324057006816 C-terminal domain interface [polypeptide binding]; other site 324057006817 active site 324057006818 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 324057006819 active site 324057006820 N-terminal domain interface [polypeptide binding]; other site 324057006821 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 324057006822 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 324057006823 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 324057006824 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 324057006825 putative active site [active] 324057006826 putative metal binding site [ion binding]; other site 324057006827 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 324057006828 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 324057006829 active site 324057006830 catalytic site [active] 324057006831 Integral membrane protein DUF92; Region: DUF92; pfam01940 324057006832 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057006833 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 324057006834 dimer interface [polypeptide binding]; other site 324057006835 putative metal binding site [ion binding]; other site 324057006836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057006837 S-adenosylmethionine binding site [chemical binding]; other site 324057006838 Putative cyclase; Region: Cyclase; pfam04199 324057006839 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 324057006840 oligoendopeptidase F; Region: pepF; TIGR00181 324057006841 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 324057006842 active site 324057006843 Zn binding site [ion binding]; other site 324057006844 Methyltransferase domain; Region: Methyltransf_11; pfam08241 324057006845 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 324057006846 DNA-binding site [nucleotide binding]; DNA binding site 324057006847 RNA-binding motif; other site 324057006848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057006849 phenyl proprionate permease family protein; Region: 2A0127; TIGR00902 324057006850 putative substrate translocation pore; other site 324057006851 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 324057006852 6-phosphofructokinase; Provisional; Region: PRK03202 324057006853 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 324057006854 active site 324057006855 ADP/pyrophosphate binding site [chemical binding]; other site 324057006856 dimerization interface [polypeptide binding]; other site 324057006857 allosteric effector site; other site 324057006858 fructose-1,6-bisphosphate binding site; other site 324057006859 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057006860 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324057006861 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057006862 Walker A/P-loop; other site 324057006863 ATP binding site [chemical binding]; other site 324057006864 Q-loop/lid; other site 324057006865 ABC transporter signature motif; other site 324057006866 Walker B; other site 324057006867 D-loop; other site 324057006868 H-loop/switch region; other site 324057006869 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057006870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057006871 active site 324057006872 phosphorylation site [posttranslational modification] 324057006873 intermolecular recognition site; other site 324057006874 dimerization interface [polypeptide binding]; other site 324057006875 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057006876 DNA binding site [nucleotide binding] 324057006877 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057006878 dimer interface [polypeptide binding]; other site 324057006879 phosphorylation site [posttranslational modification] 324057006880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057006881 ATP binding site [chemical binding]; other site 324057006882 Mg2+ binding site [ion binding]; other site 324057006883 G-X-G motif; other site 324057006884 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057006885 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057006886 dimerization interface [polypeptide binding]; other site 324057006887 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057006888 dimer interface [polypeptide binding]; other site 324057006889 phosphorylation site [posttranslational modification] 324057006890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057006891 ATP binding site [chemical binding]; other site 324057006892 Mg2+ binding site [ion binding]; other site 324057006893 G-X-G motif; other site 324057006894 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057006895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057006896 active site 324057006897 phosphorylation site [posttranslational modification] 324057006898 intermolecular recognition site; other site 324057006899 dimerization interface [polypeptide binding]; other site 324057006900 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057006901 DNA binding site [nucleotide binding] 324057006902 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 324057006903 Protein export membrane protein; Region: SecD_SecF; cl14618 324057006904 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 324057006905 Uncharacterized conserved protein [Function unknown]; Region: COG1284 324057006906 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324057006907 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324057006908 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 324057006909 helicase 45; Provisional; Region: PTZ00424 324057006910 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 324057006911 ATP binding site [chemical binding]; other site 324057006912 Mg++ binding site [ion binding]; other site 324057006913 motif III; other site 324057006914 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057006915 nucleotide binding region [chemical binding]; other site 324057006916 ATP-binding site [chemical binding]; other site 324057006917 Protein of unknown function, DUF624; Region: DUF624; cl02369 324057006918 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 324057006919 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 324057006920 dimer interface [polypeptide binding]; other site 324057006921 catalytic triad [active] 324057006922 peroxidatic and resolving cysteines [active] 324057006923 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 324057006924 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057006925 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057006926 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 324057006927 putative dimerization interface [polypeptide binding]; other site 324057006928 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 324057006929 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 324057006930 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324057006931 DNA binding residues [nucleotide binding] 324057006932 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 324057006933 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 324057006934 metal binding triad; other site 324057006935 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 324057006936 hypothetical protein; Provisional; Region: PRK07740 324057006937 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 324057006938 active site 324057006939 catalytic site [active] 324057006940 substrate binding site [chemical binding]; other site 324057006941 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 324057006942 MPN+ (JAMM) motif; other site 324057006943 Zinc-binding site [ion binding]; other site 324057006944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057006945 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057006946 putative substrate translocation pore; other site 324057006947 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 324057006948 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 324057006949 catalytic residues [active] 324057006950 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 324057006951 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 324057006952 active site 324057006953 catalytic residues [active] 324057006954 metal binding site [ion binding]; metal-binding site 324057006955 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 324057006956 DNA polymerase IV; Validated; Region: PRK01810 324057006957 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 324057006958 active site 324057006959 DNA binding site [nucleotide binding] 324057006960 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 324057006961 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 324057006962 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 324057006963 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 324057006964 quinone interaction residues [chemical binding]; other site 324057006965 active site 324057006966 catalytic residues [active] 324057006967 FMN binding site [chemical binding]; other site 324057006968 substrate binding site [chemical binding]; other site 324057006969 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 324057006970 synthetase active site [active] 324057006971 NTP binding site [chemical binding]; other site 324057006972 metal binding site [ion binding]; metal-binding site 324057006973 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057006974 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057006975 DNA binding site [nucleotide binding] 324057006976 domain linker motif; other site 324057006977 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 324057006978 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 324057006979 dimerization interface [polypeptide binding]; other site 324057006980 putative active cleft [active] 324057006981 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 324057006982 active site 324057006983 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 324057006984 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 324057006985 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 324057006986 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057006987 MarR family; Region: MarR; pfam01047 324057006988 Predicted membrane protein [Function unknown]; Region: COG1511 324057006989 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 324057006990 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057006991 active site 324057006992 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 324057006993 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 324057006994 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057006995 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 324057006996 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 324057006997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057006998 S-adenosylmethionine binding site [chemical binding]; other site 324057006999 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 324057007000 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 324057007001 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324057007002 RNA binding surface [nucleotide binding]; other site 324057007003 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 324057007004 active site 324057007005 uracil binding [chemical binding]; other site 324057007006 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057007007 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 324057007008 active site 324057007009 motif I; other site 324057007010 motif II; other site 324057007011 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057007012 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 324057007013 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 324057007014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057007015 S-adenosylmethionine binding site [chemical binding]; other site 324057007016 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 324057007017 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 324057007018 DEAD-like helicases superfamily; Region: DEXDc; smart00487 324057007019 ATP binding site [chemical binding]; other site 324057007020 Mg++ binding site [ion binding]; other site 324057007021 motif III; other site 324057007022 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057007023 nucleotide binding region [chemical binding]; other site 324057007024 ATP-binding site [chemical binding]; other site 324057007025 conserved hypothetical protein; Region: TIGR03833 324057007026 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057007027 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057007028 Coenzyme A binding pocket [chemical binding]; other site 324057007029 LysE type translocator; Region: LysE; cl00565 324057007030 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 324057007031 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 324057007032 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 324057007033 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 324057007034 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 324057007035 dimer interface [polypeptide binding]; other site 324057007036 putative functional site; other site 324057007037 putative MPT binding site; other site 324057007038 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 324057007039 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057007040 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 324057007041 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 324057007042 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 324057007043 [4Fe-4S] binding site [ion binding]; other site 324057007044 molybdopterin cofactor binding site; other site 324057007045 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 324057007046 molybdopterin cofactor binding site; other site 324057007047 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 324057007048 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 324057007049 GTP binding site; other site 324057007050 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 324057007051 Walker A motif; other site 324057007052 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057007053 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057007054 dimer interface [polypeptide binding]; other site 324057007055 phosphorylation site [posttranslational modification] 324057007056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057007057 ATP binding site [chemical binding]; other site 324057007058 Mg2+ binding site [ion binding]; other site 324057007059 G-X-G motif; other site 324057007060 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324057007061 MarR family; Region: MarR_2; pfam12802 324057007062 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057007063 arsenical pump membrane protein; Provisional; Region: PRK15445 324057007064 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 324057007065 transmembrane helices; other site 324057007066 Low molecular weight phosphatase family; Region: LMWPc; cd00115 324057007067 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 324057007068 active site 324057007069 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 324057007070 Predicted membrane protein [Function unknown]; Region: COG3766 324057007071 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 324057007072 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 324057007073 HIGH motif; other site 324057007074 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 324057007075 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324057007076 active site 324057007077 KMSKS motif; other site 324057007078 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 324057007079 tRNA binding surface [nucleotide binding]; other site 324057007080 late competence protein ComER; Validated; Region: PRK07680 324057007081 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 324057007082 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 324057007083 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 324057007084 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248 324057007085 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 324057007086 homodimer interface [polypeptide binding]; other site 324057007087 substrate-cofactor binding pocket; other site 324057007088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057007089 catalytic residue [active] 324057007090 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 324057007091 catalytic motif [active] 324057007092 Zn binding site [ion binding]; other site 324057007093 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 324057007094 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 324057007095 Competence protein; Region: Competence; pfam03772 324057007096 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 324057007097 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057007098 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057007099 DNA binding residues [nucleotide binding] 324057007100 Putative zinc-finger; Region: zf-HC2; pfam13490 324057007101 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 324057007102 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 324057007103 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 324057007104 germination protease; Provisional; Region: PRK02858 324057007105 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 324057007106 stage II sporulation protein P; Region: spore_II_P; TIGR02867 324057007107 GTP-binding protein LepA; Provisional; Region: PRK05433 324057007108 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 324057007109 G1 box; other site 324057007110 putative GEF interaction site [polypeptide binding]; other site 324057007111 GTP/Mg2+ binding site [chemical binding]; other site 324057007112 Switch I region; other site 324057007113 G2 box; other site 324057007114 G3 box; other site 324057007115 Switch II region; other site 324057007116 G4 box; other site 324057007117 G5 box; other site 324057007118 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 324057007119 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 324057007120 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 324057007121 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 324057007122 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057007123 FeS/SAM binding site; other site 324057007124 HemN C-terminal domain; Region: HemN_C; pfam06969 324057007125 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324057007126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057007127 Coenzyme A binding pocket [chemical binding]; other site 324057007128 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 324057007129 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 324057007130 GrpE; Region: GrpE; pfam01025 324057007131 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 324057007132 dimer interface [polypeptide binding]; other site 324057007133 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 324057007134 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 324057007135 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 324057007136 nucleotide binding site [chemical binding]; other site 324057007137 NEF interaction site [polypeptide binding]; other site 324057007138 SBD interface [polypeptide binding]; other site 324057007139 chaperone protein DnaJ; Provisional; Region: PRK14280 324057007140 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 324057007141 HSP70 interaction site [polypeptide binding]; other site 324057007142 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 324057007143 substrate binding site [polypeptide binding]; other site 324057007144 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 324057007145 Zn binding sites [ion binding]; other site 324057007146 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 324057007147 dimer interface [polypeptide binding]; other site 324057007148 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 324057007149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057007150 S-adenosylmethionine binding site [chemical binding]; other site 324057007151 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 324057007152 Peptidase family M50; Region: Peptidase_M50; pfam02163 324057007153 active site 324057007154 putative substrate binding region [chemical binding]; other site 324057007155 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 324057007156 RNA methyltransferase, RsmE family; Region: TIGR00046 324057007157 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 324057007158 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 324057007159 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057007160 FeS/SAM binding site; other site 324057007161 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 324057007162 active site 324057007163 Ap6A binding site [chemical binding]; other site 324057007164 nudix motif; other site 324057007165 metal binding site [ion binding]; metal-binding site 324057007166 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 324057007167 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 324057007168 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 324057007169 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 324057007170 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 324057007171 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 324057007172 putative RNA binding site [nucleotide binding]; other site 324057007173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057007174 S-adenosylmethionine binding site [chemical binding]; other site 324057007175 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 324057007176 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 324057007177 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 324057007178 DEAD/DEAH box helicase; Region: DEAD; pfam00270 324057007179 Family description; Region: UvrD_C_2; pfam13538 324057007180 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 324057007181 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 324057007182 nucleotide binding site/active site [active] 324057007183 HIT family signature motif; other site 324057007184 catalytic residue [active] 324057007185 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 324057007186 Yqey-like protein; Region: YqeY; pfam09424 324057007187 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 324057007188 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 324057007189 dimer interface [polypeptide binding]; other site 324057007190 active site residues [active] 324057007191 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 324057007192 hypothetical protein; Provisional; Region: PRK13665 324057007193 YabP family; Region: YabP; cl06766 324057007194 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 324057007195 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 324057007196 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 324057007197 PhoH-like protein; Region: PhoH; pfam02562 324057007198 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 324057007199 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 324057007200 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057007201 Zn2+ binding site [ion binding]; other site 324057007202 Mg2+ binding site [ion binding]; other site 324057007203 metal-binding heat shock protein; Provisional; Region: PRK00016 324057007204 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 324057007205 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 324057007206 active site 324057007207 catalytic motif [active] 324057007208 Zn binding site [ion binding]; other site 324057007209 GTPase Era; Reviewed; Region: era; PRK00089 324057007210 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 324057007211 G1 box; other site 324057007212 GTP/Mg2+ binding site [chemical binding]; other site 324057007213 Switch I region; other site 324057007214 G2 box; other site 324057007215 Switch II region; other site 324057007216 G3 box; other site 324057007217 G4 box; other site 324057007218 G5 box; other site 324057007219 KH domain; Region: KH_2; pfam07650 324057007220 YqzL-like protein; Region: YqzL; pfam14006 324057007221 Recombination protein O N terminal; Region: RecO_N; pfam11967 324057007222 DNA repair protein RecO; Region: reco; TIGR00613 324057007223 Recombination protein O C terminal; Region: RecO_C; pfam02565 324057007224 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 324057007225 dimer interface [polypeptide binding]; other site 324057007226 motif 1; other site 324057007227 active site 324057007228 motif 2; other site 324057007229 motif 3; other site 324057007230 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 324057007231 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 324057007232 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 324057007233 DNA primase; Validated; Region: dnaG; PRK05667 324057007234 CHC2 zinc finger; Region: zf-CHC2; pfam01807 324057007235 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 324057007236 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 324057007237 active site 324057007238 metal binding site [ion binding]; metal-binding site 324057007239 interdomain interaction site; other site 324057007240 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 324057007241 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 324057007242 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 324057007243 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 324057007244 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057007245 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 324057007246 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057007247 DNA binding residues [nucleotide binding] 324057007248 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 324057007249 Family of unknown function (DUF633); Region: DUF633; pfam04816 324057007250 Uncharacterized conserved protein [Function unknown]; Region: COG0327 324057007251 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 324057007252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 324057007253 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 324057007254 Uncharacterized conserved protein [Function unknown]; Region: COG0327 324057007255 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 324057007256 active site 324057007257 catalytic triad [active] 324057007258 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 324057007259 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 324057007260 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 324057007261 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 324057007262 Walker A/P-loop; other site 324057007263 ATP binding site [chemical binding]; other site 324057007264 Q-loop/lid; other site 324057007265 ABC transporter signature motif; other site 324057007266 Walker B; other site 324057007267 D-loop; other site 324057007268 H-loop/switch region; other site 324057007269 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 324057007270 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 324057007271 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 324057007272 Part of AAA domain; Region: AAA_19; pfam13245 324057007273 Family description; Region: UvrD_C_2; pfam13538 324057007274 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 324057007275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057007276 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324057007277 non-specific DNA binding site [nucleotide binding]; other site 324057007278 salt bridge; other site 324057007279 sequence-specific DNA binding site [nucleotide binding]; other site 324057007280 glycogen branching enzyme; Provisional; Region: PRK12313 324057007281 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 324057007282 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 324057007283 active site 324057007284 catalytic site [active] 324057007285 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 324057007286 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 324057007287 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 324057007288 ligand binding site; other site 324057007289 oligomer interface; other site 324057007290 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 324057007291 dimer interface [polypeptide binding]; other site 324057007292 N-terminal domain interface [polypeptide binding]; other site 324057007293 sulfate 1 binding site; other site 324057007294 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 324057007295 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 324057007296 ligand binding site; other site 324057007297 oligomer interface; other site 324057007298 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 324057007299 dimer interface [polypeptide binding]; other site 324057007300 N-terminal domain interface [polypeptide binding]; other site 324057007301 sulfate 1 binding site; other site 324057007302 glycogen synthase; Provisional; Region: glgA; PRK00654 324057007303 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 324057007304 ADP-binding pocket [chemical binding]; other site 324057007305 homodimer interface [polypeptide binding]; other site 324057007306 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 324057007307 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 324057007308 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 324057007309 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 324057007310 Spore germination protein GerPC; Region: GerPC; pfam10737 324057007311 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 324057007312 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 324057007313 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 324057007314 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 324057007315 metal binding site 2 [ion binding]; metal-binding site 324057007316 putative DNA binding helix; other site 324057007317 metal binding site 1 [ion binding]; metal-binding site 324057007318 dimer interface [polypeptide binding]; other site 324057007319 structural Zn2+ binding site [ion binding]; other site 324057007320 Haemolytic domain; Region: Haemolytic; pfam01809 324057007321 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 324057007322 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 324057007323 active site 324057007324 HIGH motif; other site 324057007325 KMSKS motif; other site 324057007326 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 324057007327 tRNA binding surface [nucleotide binding]; other site 324057007328 anticodon binding site; other site 324057007329 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 324057007330 dimer interface [polypeptide binding]; other site 324057007331 putative tRNA-binding site [nucleotide binding]; other site 324057007332 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 324057007333 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 324057007334 metal binding site [ion binding]; metal-binding site 324057007335 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057007336 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 324057007337 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 324057007338 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057007339 ABC-ATPase subunit interface; other site 324057007340 dimer interface [polypeptide binding]; other site 324057007341 putative PBP binding regions; other site 324057007342 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 324057007343 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 324057007344 manganese transport transcriptional regulator; Provisional; Region: PRK03902 324057007345 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 324057007346 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 324057007347 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 324057007348 ligand binding site [chemical binding]; other site 324057007349 active site 324057007350 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 324057007351 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 324057007352 active site 324057007353 nucleophile elbow; other site 324057007354 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 324057007355 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 324057007356 Conserved membrane protein YqhR; Region: YqhR; pfam11085 324057007357 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 324057007358 Dehydroquinase class II; Region: DHquinase_II; pfam01220 324057007359 trimer interface [polypeptide binding]; other site 324057007360 active site 324057007361 dimer interface [polypeptide binding]; other site 324057007362 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 324057007363 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 324057007364 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 324057007365 active site 324057007366 elongation factor P; Validated; Region: PRK00529 324057007367 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 324057007368 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 324057007369 RNA binding site [nucleotide binding]; other site 324057007370 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 324057007371 RNA binding site [nucleotide binding]; other site 324057007372 aspartate kinase; Reviewed; Region: PRK06635 324057007373 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 324057007374 putative nucleotide binding site [chemical binding]; other site 324057007375 putative catalytic residues [active] 324057007376 putative Mg ion binding site [ion binding]; other site 324057007377 putative aspartate binding site [chemical binding]; other site 324057007378 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 324057007379 putative allosteric regulatory site; other site 324057007380 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 324057007381 Protein of unknown function (DUF441); Region: DUF441; pfam04284 324057007382 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 324057007383 2-phosphosulfolactate phosphatase; Provisional; Region: PRK14100 324057007384 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 324057007385 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 324057007386 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 324057007387 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 324057007388 Walker A motif; other site 324057007389 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 324057007390 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 324057007391 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 324057007392 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 324057007393 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 324057007394 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 324057007395 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 324057007396 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 324057007397 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 324057007398 carboxyltransferase (CT) interaction site; other site 324057007399 biotinylation site [posttranslational modification]; other site 324057007400 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 324057007401 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 324057007402 ATP-grasp domain; Region: ATP-grasp_4; cl17255 324057007403 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 324057007404 Asp23 family; Region: Asp23; pfam03780 324057007405 Asp23 family; Region: Asp23; cl00574 324057007406 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 324057007407 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 324057007408 putative RNA binding site [nucleotide binding]; other site 324057007409 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 324057007410 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 324057007411 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 324057007412 homodimer interface [polypeptide binding]; other site 324057007413 NADP binding site [chemical binding]; other site 324057007414 substrate binding site [chemical binding]; other site 324057007415 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 324057007416 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 324057007417 generic binding surface II; other site 324057007418 generic binding surface I; other site 324057007419 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 324057007420 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 324057007421 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 324057007422 substrate binding pocket [chemical binding]; other site 324057007423 chain length determination region; other site 324057007424 substrate-Mg2+ binding site; other site 324057007425 catalytic residues [active] 324057007426 aspartate-rich region 1; other site 324057007427 active site lid residues [active] 324057007428 aspartate-rich region 2; other site 324057007429 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 324057007430 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 324057007431 TPP-binding site; other site 324057007432 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 324057007433 PYR/PP interface [polypeptide binding]; other site 324057007434 dimer interface [polypeptide binding]; other site 324057007435 TPP binding site [chemical binding]; other site 324057007436 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 324057007437 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 324057007438 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324057007439 RNA binding surface [nucleotide binding]; other site 324057007440 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 324057007441 arginine repressor; Provisional; Region: PRK04280 324057007442 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 324057007443 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 324057007444 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 324057007445 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 324057007446 Walker A/P-loop; other site 324057007447 ATP binding site [chemical binding]; other site 324057007448 Q-loop/lid; other site 324057007449 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 324057007450 Q-loop/lid; other site 324057007451 ABC transporter signature motif; other site 324057007452 Walker B; other site 324057007453 D-loop; other site 324057007454 H-loop/switch region; other site 324057007455 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 324057007456 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 324057007457 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 324057007458 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 324057007459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057007460 active site 324057007461 phosphorylation site [posttranslational modification] 324057007462 intermolecular recognition site; other site 324057007463 dimerization interface [polypeptide binding]; other site 324057007464 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 324057007465 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 324057007466 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 324057007467 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 324057007468 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057007469 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 324057007470 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 324057007471 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 324057007472 tetramer interface [polypeptide binding]; other site 324057007473 TPP-binding site [chemical binding]; other site 324057007474 heterodimer interface [polypeptide binding]; other site 324057007475 phosphorylation loop region [posttranslational modification] 324057007476 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 324057007477 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 324057007478 alpha subunit interface [polypeptide binding]; other site 324057007479 TPP binding site [chemical binding]; other site 324057007480 heterodimer interface [polypeptide binding]; other site 324057007481 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 324057007482 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 324057007483 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 324057007484 peptidase T-like protein; Region: PepT-like; TIGR01883 324057007485 metal binding site [ion binding]; metal-binding site 324057007486 putative dimer interface [polypeptide binding]; other site 324057007487 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 324057007488 dimer interface [polypeptide binding]; other site 324057007489 ADP-ribose binding site [chemical binding]; other site 324057007490 active site 324057007491 nudix motif; other site 324057007492 metal binding site [ion binding]; metal-binding site 324057007493 Integral membrane protein DUF95; Region: DUF95; cl00572 324057007494 ferric uptake regulator; Provisional; Region: fur; PRK09462 324057007495 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 324057007496 metal binding site 2 [ion binding]; metal-binding site 324057007497 putative DNA binding helix; other site 324057007498 metal binding site 1 [ion binding]; metal-binding site 324057007499 dimer interface [polypeptide binding]; other site 324057007500 structural Zn2+ binding site [ion binding]; other site 324057007501 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 324057007502 active site 324057007503 catalytic residues [active] 324057007504 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 324057007505 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 324057007506 hexamer interface [polypeptide binding]; other site 324057007507 ligand binding site [chemical binding]; other site 324057007508 putative active site [active] 324057007509 NAD(P) binding site [chemical binding]; other site 324057007510 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 324057007511 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 324057007512 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 324057007513 active site 324057007514 Int/Topo IB signature motif; other site 324057007515 phosphopentomutase; Provisional; Region: PRK05362 324057007516 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 324057007517 purine nucleoside phosphorylase; Provisional; Region: PRK08202 324057007518 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 324057007519 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 324057007520 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 324057007521 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 324057007522 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 324057007523 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 324057007524 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 324057007525 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 324057007526 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 324057007527 anti sigma factor interaction site; other site 324057007528 regulatory phosphorylation site [posttranslational modification]; other site 324057007529 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 324057007530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057007531 ATP binding site [chemical binding]; other site 324057007532 Mg2+ binding site [ion binding]; other site 324057007533 G-X-G motif; other site 324057007534 sporulation sigma factor SigF; Validated; Region: PRK05572 324057007535 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057007536 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 324057007537 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057007538 DNA binding residues [nucleotide binding] 324057007539 topology modulation protein; Provisional; Region: PRK07261 324057007540 AAA domain; Region: AAA_17; pfam13207 324057007541 topology modulation protein; Reviewed; Region: PRK08118 324057007542 AAA domain; Region: AAA_17; pfam13207 324057007543 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 324057007544 CCGSCS motif protein; Region: CCGSCS; TIGR04101 324057007545 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 324057007546 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057007547 diaminopimelate decarboxylase; Region: lysA; TIGR01048 324057007548 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 324057007549 active site 324057007550 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 324057007551 substrate binding site [chemical binding]; other site 324057007552 catalytic residues [active] 324057007553 dimer interface [polypeptide binding]; other site 324057007554 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 324057007555 active site 324057007556 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 324057007557 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 324057007558 catalytic motif [active] 324057007559 Zn binding site [ion binding]; other site 324057007560 RibD C-terminal domain; Region: RibD_C; cl17279 324057007561 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 324057007562 Lumazine binding domain; Region: Lum_binding; pfam00677 324057007563 Lumazine binding domain; Region: Lum_binding; pfam00677 324057007564 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 324057007565 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 324057007566 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 324057007567 dimerization interface [polypeptide binding]; other site 324057007568 active site 324057007569 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 324057007570 homopentamer interface [polypeptide binding]; other site 324057007571 active site 324057007572 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 324057007573 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 324057007574 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 324057007575 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 324057007576 Walker A/P-loop; other site 324057007577 ATP binding site [chemical binding]; other site 324057007578 Q-loop/lid; other site 324057007579 ABC transporter signature motif; other site 324057007580 Walker B; other site 324057007581 D-loop; other site 324057007582 H-loop/switch region; other site 324057007583 NIL domain; Region: NIL; pfam09383 324057007584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057007585 dimer interface [polypeptide binding]; other site 324057007586 conserved gate region; other site 324057007587 ABC-ATPase subunit interface; other site 324057007588 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 324057007589 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 324057007590 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 324057007591 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 324057007592 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 324057007593 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 324057007594 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 324057007595 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 324057007596 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 324057007597 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 324057007598 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324057007599 RNA binding surface [nucleotide binding]; other site 324057007600 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 324057007601 active site 324057007602 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 324057007603 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 324057007604 catalytic residues [active] 324057007605 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 324057007606 ResB-like family; Region: ResB; pfam05140 324057007607 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 324057007608 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 324057007609 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057007610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057007611 active site 324057007612 phosphorylation site [posttranslational modification] 324057007613 intermolecular recognition site; other site 324057007614 dimerization interface [polypeptide binding]; other site 324057007615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057007616 DNA binding site [nucleotide binding] 324057007617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 324057007618 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057007619 dimerization interface [polypeptide binding]; other site 324057007620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057007621 dimer interface [polypeptide binding]; other site 324057007622 phosphorylation site [posttranslational modification] 324057007623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057007624 ATP binding site [chemical binding]; other site 324057007625 Mg2+ binding site [ion binding]; other site 324057007626 G-X-G motif; other site 324057007627 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 324057007628 arsenical pump membrane protein; Provisional; Region: PRK15445 324057007629 transmembrane helices; other site 324057007630 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 324057007631 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 324057007632 ligand binding site [chemical binding]; other site 324057007633 NAD binding site [chemical binding]; other site 324057007634 dimerization interface [polypeptide binding]; other site 324057007635 catalytic site [active] 324057007636 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 324057007637 putative L-serine binding site [chemical binding]; other site 324057007638 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 324057007639 active site residue [active] 324057007640 CAAX protease self-immunity; Region: Abi; pfam02517 324057007641 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 324057007642 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 324057007643 NodB motif; other site 324057007644 active site 324057007645 catalytic site [active] 324057007646 metal binding site [ion binding]; metal-binding site 324057007647 adaptor protein; Provisional; Region: PRK02899 324057007648 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 324057007649 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 324057007650 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 324057007651 NAD(P) binding site [chemical binding]; other site 324057007652 Protease prsW family; Region: PrsW-protease; pfam13367 324057007653 germination protein YpeB; Region: spore_YpeB; TIGR02889 324057007654 Flagellar protein YcgR; Region: YcgR_2; pfam12945 324057007655 PilZ domain; Region: PilZ; pfam07238 324057007656 cytidylate kinase; Provisional; Region: cmk; PRK00023 324057007657 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 324057007658 CMP-binding site; other site 324057007659 The sites determining sugar specificity; other site 324057007660 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 324057007661 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 324057007662 putative acyl-acceptor binding pocket; other site 324057007663 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 324057007664 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 324057007665 RNA binding site [nucleotide binding]; other site 324057007666 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 324057007667 RNA binding site [nucleotide binding]; other site 324057007668 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 324057007669 RNA binding site [nucleotide binding]; other site 324057007670 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 324057007671 RNA binding site [nucleotide binding]; other site 324057007672 YIEGIA protein; Region: YIEGIA; pfam14045 324057007673 GTP-binding protein Der; Reviewed; Region: PRK00093 324057007674 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 324057007675 G1 box; other site 324057007676 GTP/Mg2+ binding site [chemical binding]; other site 324057007677 Switch I region; other site 324057007678 G2 box; other site 324057007679 Switch II region; other site 324057007680 G3 box; other site 324057007681 G4 box; other site 324057007682 G5 box; other site 324057007683 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 324057007684 G1 box; other site 324057007685 GTP/Mg2+ binding site [chemical binding]; other site 324057007686 Switch I region; other site 324057007687 G2 box; other site 324057007688 G3 box; other site 324057007689 Switch II region; other site 324057007690 G4 box; other site 324057007691 G5 box; other site 324057007692 membrane protein; Provisional; Region: PRK14405 324057007693 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 324057007694 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 324057007695 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 324057007696 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 324057007697 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 324057007698 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 324057007699 catalytic loop [active] 324057007700 iron binding site [ion binding]; other site 324057007701 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 324057007702 catalytic loop [active] 324057007703 iron binding site [ion binding]; other site 324057007704 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 324057007705 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 324057007706 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 324057007707 G1 box; other site 324057007708 GTP/Mg2+ binding site [chemical binding]; other site 324057007709 G2 box; other site 324057007710 Switch I region; other site 324057007711 G3 box; other site 324057007712 Switch II region; other site 324057007713 G5 box; other site 324057007714 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 324057007715 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057007716 putative ligand binding site [chemical binding]; other site 324057007717 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 324057007718 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 324057007719 Walker A/P-loop; other site 324057007720 ATP binding site [chemical binding]; other site 324057007721 Q-loop/lid; other site 324057007722 ABC transporter signature motif; other site 324057007723 Walker B; other site 324057007724 D-loop; other site 324057007725 H-loop/switch region; other site 324057007726 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 324057007727 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 324057007728 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 324057007729 TM-ABC transporter signature motif; other site 324057007730 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 324057007731 IHF dimer interface [polypeptide binding]; other site 324057007732 IHF - DNA interface [nucleotide binding]; other site 324057007733 transcription attenuation protein MtrB; Provisional; Region: PRK13251 324057007734 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 324057007735 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 324057007736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057007737 S-adenosylmethionine binding site [chemical binding]; other site 324057007738 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 324057007739 UbiA prenyltransferase family; Region: UbiA; pfam01040 324057007740 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 324057007741 Flavoprotein; Region: Flavoprotein; pfam02441 324057007742 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 324057007743 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 324057007744 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 324057007745 substrate binding pocket [chemical binding]; other site 324057007746 chain length determination region; other site 324057007747 substrate-Mg2+ binding site; other site 324057007748 catalytic residues [active] 324057007749 aspartate-rich region 1; other site 324057007750 active site lid residues [active] 324057007751 aspartate-rich region 2; other site 324057007752 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 324057007753 active site 324057007754 multimer interface [polypeptide binding]; other site 324057007755 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 324057007756 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 324057007757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057007758 S-adenosylmethionine binding site [chemical binding]; other site 324057007759 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 324057007760 active site 324057007761 dimer interface [polypeptide binding]; other site 324057007762 metal binding site [ion binding]; metal-binding site 324057007763 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 324057007764 homotrimer interaction site [polypeptide binding]; other site 324057007765 active site 324057007766 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 324057007767 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 324057007768 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 324057007769 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 324057007770 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 324057007771 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 324057007772 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 324057007773 active site 324057007774 ribulose/triose binding site [chemical binding]; other site 324057007775 phosphate binding site [ion binding]; other site 324057007776 substrate (anthranilate) binding pocket [chemical binding]; other site 324057007777 product (indole) binding pocket [chemical binding]; other site 324057007778 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 324057007779 active site 324057007780 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 324057007781 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 324057007782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057007783 catalytic residue [active] 324057007784 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 324057007785 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 324057007786 substrate binding site [chemical binding]; other site 324057007787 active site 324057007788 catalytic residues [active] 324057007789 heterodimer interface [polypeptide binding]; other site 324057007790 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 324057007791 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057007792 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057007793 homodimer interface [polypeptide binding]; other site 324057007794 catalytic residue [active] 324057007795 prephenate dehydrogenase; Validated; Region: PRK06545 324057007796 prephenate dehydrogenase; Validated; Region: PRK08507 324057007797 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 324057007798 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 324057007799 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057007800 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057007801 DNA binding residues [nucleotide binding] 324057007802 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 324057007803 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324057007804 catalytic core [active] 324057007805 A short protein domain of unknown function; Region: IDEAL; smart00914 324057007806 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 324057007807 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 324057007808 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 324057007809 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 324057007810 iron-sulfur cluster [ion binding]; other site 324057007811 [2Fe-2S] cluster binding site [ion binding]; other site 324057007812 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 324057007813 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 324057007814 interchain domain interface [polypeptide binding]; other site 324057007815 intrachain domain interface; other site 324057007816 heme bH binding site [chemical binding]; other site 324057007817 Qi binding site; other site 324057007818 heme bL binding site [chemical binding]; other site 324057007819 Qo binding site; other site 324057007820 intrachain domain interface; other site 324057007821 Qi binding site; other site 324057007822 interchain domain interface [polypeptide binding]; other site 324057007823 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 324057007824 Qo binding site; other site 324057007825 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 324057007826 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 324057007827 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 324057007828 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 324057007829 Uncharacterized conserved protein [Function unknown]; Region: COG1284 324057007830 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324057007831 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324057007832 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 324057007833 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 324057007834 homodimer interface [polypeptide binding]; other site 324057007835 metal binding site [ion binding]; metal-binding site 324057007836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057007837 TPR repeat; Region: TPR_11; pfam13414 324057007838 TPR motif; other site 324057007839 binding surface 324057007840 dihydrodipicolinate reductase; Provisional; Region: PRK00048 324057007841 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 324057007842 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 324057007843 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 324057007844 active site 324057007845 dimer interfaces [polypeptide binding]; other site 324057007846 catalytic residues [active] 324057007847 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 324057007848 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 324057007849 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 324057007850 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 324057007851 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 324057007852 active site 324057007853 NTP binding site [chemical binding]; other site 324057007854 metal binding triad [ion binding]; metal-binding site 324057007855 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 324057007856 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 324057007857 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057007858 dimerization interface [polypeptide binding]; other site 324057007859 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 324057007860 putative Zn2+ binding site [ion binding]; other site 324057007861 putative DNA binding site [nucleotide binding]; other site 324057007862 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 324057007863 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 324057007864 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 324057007865 oligomerization interface [polypeptide binding]; other site 324057007866 active site 324057007867 metal binding site [ion binding]; metal-binding site 324057007868 Pantoate-beta-alanine ligase; Region: PanC; cd00560 324057007869 pantoate--beta-alanine ligase; Region: panC; TIGR00018 324057007870 active site 324057007871 ATP-binding site [chemical binding]; other site 324057007872 pantoate-binding site; other site 324057007873 HXXH motif; other site 324057007874 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 324057007875 tetramerization interface [polypeptide binding]; other site 324057007876 active site 324057007877 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057007878 TPR motif; other site 324057007879 binding surface 324057007880 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324057007881 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 324057007882 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 324057007883 active site 324057007884 catalytic site [active] 324057007885 substrate binding site [chemical binding]; other site 324057007886 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057007887 ATP binding site [chemical binding]; other site 324057007888 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 324057007889 putative Mg++ binding site [ion binding]; other site 324057007890 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 324057007891 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 324057007892 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 324057007893 CoA binding domain; Region: CoA_binding; pfam02629 324057007894 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 324057007895 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 324057007896 active site 324057007897 putative substrate binding pocket [chemical binding]; other site 324057007898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 324057007899 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 324057007900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057007901 Walker A motif; other site 324057007902 ATP binding site [chemical binding]; other site 324057007903 Walker B motif; other site 324057007904 arginine finger; other site 324057007905 Peptidase family M41; Region: Peptidase_M41; pfam01434 324057007906 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 324057007907 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 324057007908 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 324057007909 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 324057007910 propionate/acetate kinase; Provisional; Region: PRK12379 324057007911 Helix-turn-helix domain; Region: HTH_36; pfam13730 324057007912 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 324057007913 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057007914 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057007915 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057007916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 324057007917 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 324057007918 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 324057007919 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 324057007920 DinB superfamily; Region: DinB_2; pfam12867 324057007921 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057007922 active site 324057007923 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 324057007924 intersubunit interface [polypeptide binding]; other site 324057007925 active site 324057007926 Zn2+ binding site [ion binding]; other site 324057007927 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 324057007928 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057007929 motif II; other site 324057007930 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 324057007931 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 324057007932 dimer interface [polypeptide binding]; other site 324057007933 active site 324057007934 catalytic residue [active] 324057007935 metal binding site [ion binding]; metal-binding site 324057007936 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 324057007937 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 324057007938 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 324057007939 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 324057007940 putative catalytic cysteine [active] 324057007941 gamma-glutamyl kinase; Provisional; Region: PRK05429 324057007942 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 324057007943 nucleotide binding site [chemical binding]; other site 324057007944 homotetrameric interface [polypeptide binding]; other site 324057007945 putative phosphate binding site [ion binding]; other site 324057007946 putative allosteric binding site; other site 324057007947 PUA domain; Region: PUA; pfam01472 324057007948 transaminase; Reviewed; Region: PRK08068 324057007949 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057007950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057007951 homodimer interface [polypeptide binding]; other site 324057007952 catalytic residue [active] 324057007953 Predicted amidohydrolase [General function prediction only]; Region: COG0388 324057007954 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 324057007955 putative active site [active] 324057007956 catalytic triad [active] 324057007957 putative dimer interface [polypeptide binding]; other site 324057007958 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057007959 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057007960 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057007961 dimerization interface [polypeptide binding]; other site 324057007962 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 324057007963 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 324057007964 substrate binding site [chemical binding]; other site 324057007965 ligand binding site [chemical binding]; other site 324057007966 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 324057007967 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 324057007968 substrate binding site [chemical binding]; other site 324057007969 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057007970 AMIN domain; Region: AMIN; pfam11741 324057007971 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 324057007972 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 324057007973 active site 324057007974 metal binding site [ion binding]; metal-binding site 324057007975 Sporulation and spore germination; Region: Germane; pfam10646 324057007976 S-layer homology domain; Region: SLH; pfam00395 324057007977 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 324057007978 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 324057007979 minor groove reading motif; other site 324057007980 helix-hairpin-helix signature motif; other site 324057007981 substrate binding pocket [chemical binding]; other site 324057007982 active site 324057007983 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 324057007984 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 324057007985 Dynamin family; Region: Dynamin_N; pfam00350 324057007986 G1 box; other site 324057007987 GTP/Mg2+ binding site [chemical binding]; other site 324057007988 G2 box; other site 324057007989 Switch I region; other site 324057007990 G3 box; other site 324057007991 Switch II region; other site 324057007992 G4 box; other site 324057007993 G5 box; other site 324057007994 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 324057007995 Dynamin family; Region: Dynamin_N; pfam00350 324057007996 G1 box; other site 324057007997 GTP/Mg2+ binding site [chemical binding]; other site 324057007998 G2 box; other site 324057007999 Switch I region; other site 324057008000 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 324057008001 G3 box; other site 324057008002 Switch II region; other site 324057008003 GTP/Mg2+ binding site [chemical binding]; other site 324057008004 G4 box; other site 324057008005 G5 box; other site 324057008006 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 324057008007 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 324057008008 metal binding site [ion binding]; metal-binding site 324057008009 active site 324057008010 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 324057008011 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324057008012 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 324057008013 H+ Antiporter protein; Region: 2A0121; TIGR00900 324057008014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057008015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057008016 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 324057008017 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 324057008018 NAD(P) binding site [chemical binding]; other site 324057008019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057008020 salt bridge; other site 324057008021 non-specific DNA binding site [nucleotide binding]; other site 324057008022 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324057008023 sequence-specific DNA binding site [nucleotide binding]; other site 324057008024 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057008025 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324057008026 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 324057008027 Walker A/P-loop; other site 324057008028 ATP binding site [chemical binding]; other site 324057008029 Q-loop/lid; other site 324057008030 ABC transporter signature motif; other site 324057008031 Walker B; other site 324057008032 D-loop; other site 324057008033 H-loop/switch region; other site 324057008034 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057008035 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324057008036 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 324057008037 Walker A/P-loop; other site 324057008038 ATP binding site [chemical binding]; other site 324057008039 Q-loop/lid; other site 324057008040 ABC transporter signature motif; other site 324057008041 Walker B; other site 324057008042 D-loop; other site 324057008043 H-loop/switch region; other site 324057008044 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 324057008045 ATP-grasp domain; Region: ATP-grasp; pfam02222 324057008046 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 324057008047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057008048 Mg2+ binding site [ion binding]; other site 324057008049 G-X-G motif; other site 324057008050 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 324057008051 anchoring element; other site 324057008052 dimer interface [polypeptide binding]; other site 324057008053 ATP binding site [chemical binding]; other site 324057008054 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 324057008055 active site 324057008056 putative metal-binding site [ion binding]; other site 324057008057 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 324057008058 DNA gyrase subunit A; Validated; Region: PRK05560 324057008059 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 324057008060 CAP-like domain; other site 324057008061 active site 324057008062 primary dimer interface [polypeptide binding]; other site 324057008063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324057008064 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324057008065 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324057008066 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057008067 MarR family; Region: MarR; pfam01047 324057008068 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 324057008069 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 324057008070 putative active site [active] 324057008071 putative metal binding site [ion binding]; other site 324057008072 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 324057008073 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 324057008074 active site 324057008075 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 324057008076 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 324057008077 active site 324057008078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057008079 sequence-specific DNA binding site [nucleotide binding]; other site 324057008080 salt bridge; other site 324057008081 L-arabinose isomerase; Provisional; Region: PRK02929 324057008082 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 324057008083 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 324057008084 trimer interface [polypeptide binding]; other site 324057008085 putative substrate binding site [chemical binding]; other site 324057008086 putative metal binding site [ion binding]; other site 324057008087 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 324057008088 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057008089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057008090 putative substrate translocation pore; other site 324057008091 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057008092 MarR family; Region: MarR_2; pfam12802 324057008093 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 324057008094 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 324057008095 NodB motif; other site 324057008096 active site 324057008097 catalytic site [active] 324057008098 Cd binding site [ion binding]; other site 324057008099 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 324057008100 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 324057008101 homodimer interface [polypeptide binding]; other site 324057008102 substrate-cofactor binding pocket; other site 324057008103 catalytic residue [active] 324057008104 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057008105 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057008106 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057008107 dimerization interface [polypeptide binding]; other site 324057008108 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 324057008109 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 324057008110 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 324057008111 Cache domain; Region: Cache_1; pfam02743 324057008112 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057008113 dimerization interface [polypeptide binding]; other site 324057008114 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057008115 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057008116 dimer interface [polypeptide binding]; other site 324057008117 putative CheW interface [polypeptide binding]; other site 324057008118 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 324057008119 dimer interface [polypeptide binding]; other site 324057008120 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057008121 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 324057008122 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057008123 Coenzyme A binding pocket [chemical binding]; other site 324057008124 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 324057008125 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 324057008126 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 324057008127 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324057008128 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 324057008129 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 324057008130 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057008131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057008132 S-adenosylmethionine binding site [chemical binding]; other site 324057008133 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 324057008134 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 324057008135 active site 324057008136 metal binding site [ion binding]; metal-binding site 324057008137 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 324057008138 active site 324057008139 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 324057008140 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 324057008141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057008142 motif II; other site 324057008143 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 324057008144 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324057008145 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057008146 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 324057008147 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 324057008148 metal binding site [ion binding]; metal-binding site 324057008149 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057008150 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 324057008151 active site 324057008152 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 324057008153 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 324057008154 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 324057008155 active site 324057008156 catalytic triad [active] 324057008157 oxyanion hole [active] 324057008158 Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802 324057008159 putative active site [active] 324057008160 YdjC motif; other site 324057008161 Mg binding site [ion binding]; other site 324057008162 homodimer interface [polypeptide binding]; other site 324057008163 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 324057008164 alpha-glucosidase; Provisional; Region: PRK10137 324057008165 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 324057008166 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057008167 Histidine kinase; Region: His_kinase; pfam06580 324057008168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057008169 ATP binding site [chemical binding]; other site 324057008170 Mg2+ binding site [ion binding]; other site 324057008171 G-X-G motif; other site 324057008172 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057008173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057008174 active site 324057008175 phosphorylation site [posttranslational modification] 324057008176 intermolecular recognition site; other site 324057008177 dimerization interface [polypeptide binding]; other site 324057008178 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057008179 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057008180 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057008181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057008182 dimer interface [polypeptide binding]; other site 324057008183 conserved gate region; other site 324057008184 putative PBP binding loops; other site 324057008185 ABC-ATPase subunit interface; other site 324057008186 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057008187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057008188 dimer interface [polypeptide binding]; other site 324057008189 conserved gate region; other site 324057008190 putative PBP binding loops; other site 324057008191 ABC-ATPase subunit interface; other site 324057008192 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057008193 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057008194 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057008195 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057008196 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 324057008197 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057008198 Glycosyl hydrolase family 52; Region: Glyco_hydro_52; pfam03512 324057008199 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057008200 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057008201 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057008202 Interdomain contacts; other site 324057008203 Cytokine receptor motif; other site 324057008204 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057008205 Interdomain contacts; other site 324057008206 Cytokine receptor motif; other site 324057008207 S-layer homology domain; Region: SLH; pfam00395 324057008208 S-layer homology domain; Region: SLH; pfam00395 324057008209 S-layer homology domain; Region: SLH; pfam00395 324057008210 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 324057008211 Response regulator receiver domain; Region: Response_reg; pfam00072 324057008212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057008213 active site 324057008214 phosphorylation site [posttranslational modification] 324057008215 intermolecular recognition site; other site 324057008216 dimerization interface [polypeptide binding]; other site 324057008217 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057008218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057008219 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057008220 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057008221 dimerization interface [polypeptide binding]; other site 324057008222 Histidine kinase; Region: His_kinase; pfam06580 324057008223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057008224 ATP binding site [chemical binding]; other site 324057008225 Mg2+ binding site [ion binding]; other site 324057008226 G-X-G motif; other site 324057008227 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057008228 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057008229 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057008230 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057008231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057008232 dimer interface [polypeptide binding]; other site 324057008233 conserved gate region; other site 324057008234 putative PBP binding loops; other site 324057008235 ABC-ATPase subunit interface; other site 324057008236 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057008237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057008238 dimer interface [polypeptide binding]; other site 324057008239 conserved gate region; other site 324057008240 putative PBP binding loops; other site 324057008241 ABC-ATPase subunit interface; other site 324057008242 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 324057008243 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 324057008244 putative sugar binding sites [chemical binding]; other site 324057008245 Q-X-W motif; other site 324057008246 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057008247 active site 324057008248 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057008249 catalytic tetrad [active] 324057008250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057008251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057008252 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 324057008253 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057008254 Coenzyme A binding pocket [chemical binding]; other site 324057008255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 324057008256 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 324057008257 active site 324057008258 catalytic triad [active] 324057008259 oxyanion hole [active] 324057008260 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057008261 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057008262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057008263 Response regulator receiver domain; Region: Response_reg; pfam00072 324057008264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057008265 active site 324057008266 phosphorylation site [posttranslational modification] 324057008267 intermolecular recognition site; other site 324057008268 dimerization interface [polypeptide binding]; other site 324057008269 Glucokinase; Region: Glucokinase; cl17310 324057008270 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057008271 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057008272 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057008273 dimerization interface [polypeptide binding]; other site 324057008274 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057008275 Histidine kinase; Region: His_kinase; pfam06580 324057008276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057008277 ATP binding site [chemical binding]; other site 324057008278 Mg2+ binding site [ion binding]; other site 324057008279 G-X-G motif; other site 324057008280 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057008281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057008282 dimer interface [polypeptide binding]; other site 324057008283 conserved gate region; other site 324057008284 ABC-ATPase subunit interface; other site 324057008285 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057008286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057008287 putative PBP binding loops; other site 324057008288 ABC-ATPase subunit interface; other site 324057008289 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057008290 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057008291 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057008292 Interdomain contacts; other site 324057008293 Cytokine receptor motif; other site 324057008294 PA14 domain; Region: PA14; cl08459 324057008295 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057008296 dockerin binding interface; other site 324057008297 S-layer homology domain; Region: SLH; pfam00395 324057008298 S-layer homology domain; Region: SLH; pfam00395 324057008299 Trehalase; Region: Trehalase; cl17346 324057008300 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 324057008301 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 324057008302 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 324057008303 active site 324057008304 metal binding site [ion binding]; metal-binding site 324057008305 homodimer interface [polypeptide binding]; other site 324057008306 catalytic site [active] 324057008307 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 324057008308 probable galactinol--sucrose galactosyltransferase 1; Region: PLN02355 324057008309 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 324057008310 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057008311 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057008312 sugar binding site [chemical binding]; other site 324057008313 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057008314 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057008315 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057008316 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057008317 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 324057008318 DNA interaction; other site 324057008319 Metal-binding active site; metal-binding site 324057008320 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057008321 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057008322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057008323 active site 324057008324 phosphorylation site [posttranslational modification] 324057008325 intermolecular recognition site; other site 324057008326 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057008327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057008328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057008329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057008330 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057008331 dimerization interface [polypeptide binding]; other site 324057008332 Histidine kinase; Region: His_kinase; pfam06580 324057008333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057008334 ATP binding site [chemical binding]; other site 324057008335 Mg2+ binding site [ion binding]; other site 324057008336 G-X-G motif; other site 324057008337 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057008338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057008339 dimer interface [polypeptide binding]; other site 324057008340 conserved gate region; other site 324057008341 putative PBP binding loops; other site 324057008342 ABC-ATPase subunit interface; other site 324057008343 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057008344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057008345 dimer interface [polypeptide binding]; other site 324057008346 conserved gate region; other site 324057008347 putative PBP binding loops; other site 324057008348 ABC-ATPase subunit interface; other site 324057008349 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 324057008350 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057008351 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 324057008352 Ca binding site [ion binding]; other site 324057008353 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 324057008354 active site 324057008355 catalytic site [active] 324057008356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 324057008357 Cupin domain; Region: Cupin_2; pfam07883 324057008358 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057008359 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057008360 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 324057008361 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 324057008362 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 324057008363 active site 324057008364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057008365 S-adenosylmethionine binding site [chemical binding]; other site 324057008366 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 324057008367 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 324057008368 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 324057008369 hydrophobic ligand binding site; other site 324057008370 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 324057008371 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 324057008372 dimer interface [polypeptide binding]; other site 324057008373 active site 324057008374 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 324057008375 active site 324057008376 metal binding site [ion binding]; metal-binding site 324057008377 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 324057008378 B12 binding site [chemical binding]; other site 324057008379 cobalt ligand [ion binding]; other site 324057008380 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 324057008381 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 324057008382 Predicted P-loop ATPase/GTPase [General function prediction only]; Region: COG4028 324057008383 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 324057008384 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 324057008385 Domain of unknown function (DUF309); Region: DUF309; pfam03745 324057008386 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 324057008387 active site clefts [active] 324057008388 zinc binding site [ion binding]; other site 324057008389 dimer interface [polypeptide binding]; other site 324057008390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 324057008391 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 324057008392 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 324057008393 active site 324057008394 Zn binding site [ion binding]; other site 324057008395 NMT1-like family; Region: NMT1_2; pfam13379 324057008396 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 324057008397 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324057008398 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 324057008399 Walker A/P-loop; other site 324057008400 ATP binding site [chemical binding]; other site 324057008401 Q-loop/lid; other site 324057008402 ABC transporter signature motif; other site 324057008403 Walker B; other site 324057008404 D-loop; other site 324057008405 H-loop/switch region; other site 324057008406 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057008407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057008408 dimer interface [polypeptide binding]; other site 324057008409 conserved gate region; other site 324057008410 putative PBP binding loops; other site 324057008411 ABC-ATPase subunit interface; other site 324057008412 Predicted membrane protein [Function unknown]; Region: COG4129 324057008413 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 324057008414 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 324057008415 Outer spore coat protein E (CotE); Region: CotE; pfam10628 324057008416 Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395 324057008417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 324057008418 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 324057008419 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 324057008420 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 324057008421 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 324057008422 MutS domain I; Region: MutS_I; pfam01624 324057008423 MutS domain II; Region: MutS_II; pfam05188 324057008424 MutS domain III; Region: MutS_III; pfam05192 324057008425 MutS domain V; Region: MutS_V; pfam00488 324057008426 Walker A/P-loop; other site 324057008427 ATP binding site [chemical binding]; other site 324057008428 Q-loop/lid; other site 324057008429 ABC transporter signature motif; other site 324057008430 Walker B; other site 324057008431 D-loop; other site 324057008432 H-loop/switch region; other site 324057008433 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 324057008434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057008435 ATP binding site [chemical binding]; other site 324057008436 Mg2+ binding site [ion binding]; other site 324057008437 G-X-G motif; other site 324057008438 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 324057008439 ATP binding site [chemical binding]; other site 324057008440 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 324057008441 ribosomal biogenesis protein; Validated; Region: PRK00933 324057008442 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 324057008443 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 324057008444 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 324057008445 bacterial Hfq-like; Region: Hfq; cd01716 324057008446 hexamer interface [polypeptide binding]; other site 324057008447 Sm1 motif; other site 324057008448 RNA binding site [nucleotide binding]; other site 324057008449 Sm2 motif; other site 324057008450 Transglycosylase; Region: Transgly; pfam00912 324057008451 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 324057008452 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 324057008453 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057008454 Interdomain contacts; other site 324057008455 Cytokine receptor motif; other site 324057008456 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 324057008457 active site 324057008458 Protein of unknown function (DUF402); Region: DUF402; cl00979 324057008459 Uncharacterized conserved protein [Function unknown]; Region: COG1434 324057008460 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 324057008461 putative active site [active] 324057008462 stage V sporulation protein K; Region: spore_V_K; TIGR02881 324057008463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057008464 Walker A motif; other site 324057008465 ATP binding site [chemical binding]; other site 324057008466 Walker B motif; other site 324057008467 arginine finger; other site 324057008468 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 324057008469 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 324057008470 HflX GTPase family; Region: HflX; cd01878 324057008471 G1 box; other site 324057008472 GTP/Mg2+ binding site [chemical binding]; other site 324057008473 Switch I region; other site 324057008474 G2 box; other site 324057008475 G3 box; other site 324057008476 Switch II region; other site 324057008477 G4 box; other site 324057008478 G5 box; other site 324057008479 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 324057008480 Aluminium resistance protein; Region: Alum_res; pfam06838 324057008481 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 324057008482 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324057008483 DNA binding residues [nucleotide binding] 324057008484 putative dimer interface [polypeptide binding]; other site 324057008485 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 324057008486 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 324057008487 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 324057008488 PspC domain; Region: PspC; cl00864 324057008489 LexA repressor; Validated; Region: PRK00215 324057008490 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057008491 putative DNA binding site [nucleotide binding]; other site 324057008492 putative Zn2+ binding site [ion binding]; other site 324057008493 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 324057008494 Catalytic site [active] 324057008495 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057008496 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 324057008497 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 324057008498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057008499 motif II; other site 324057008500 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 324057008501 Cupin domain; Region: Cupin_2; cl17218 324057008502 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 324057008503 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 324057008504 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 324057008505 substrate binding pocket [chemical binding]; other site 324057008506 dimer interface [polypeptide binding]; other site 324057008507 inhibitor binding site; inhibition site 324057008508 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 324057008509 B12 binding site [chemical binding]; other site 324057008510 cobalt ligand [ion binding]; other site 324057008511 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 324057008512 ribonuclease Z; Region: RNase_Z; TIGR02651 324057008513 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 324057008514 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 324057008515 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057008516 ATP binding site [chemical binding]; other site 324057008517 putative Mg++ binding site [ion binding]; other site 324057008518 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057008519 nucleotide binding region [chemical binding]; other site 324057008520 ATP-binding site [chemical binding]; other site 324057008521 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 324057008522 RNase_H superfamily; Region: RNase_H_2; pfam13482 324057008523 active site 324057008524 substrate binding site [chemical binding]; other site 324057008525 catalytic site [active] 324057008526 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 324057008527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057008528 active site 324057008529 motif I; other site 324057008530 motif II; other site 324057008531 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057008532 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 324057008533 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 324057008534 putative DNA binding site [nucleotide binding]; other site 324057008535 catalytic residue [active] 324057008536 putative H2TH interface [polypeptide binding]; other site 324057008537 putative catalytic residues [active] 324057008538 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 324057008539 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 324057008540 AP endonuclease family 2; Region: AP2Ec; smart00518 324057008541 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 324057008542 AP (apurinic/apyrimidinic) site pocket; other site 324057008543 DNA interaction; other site 324057008544 Metal-binding active site; metal-binding site 324057008545 THUMP domain, predicted to bind RNA; Region: THUMP; cl12076 324057008546 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 324057008547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057008548 S-adenosylmethionine binding site [chemical binding]; other site 324057008549 Protein kinase domain; Region: Pkinase; pfam00069 324057008550 Catalytic domain of Protein Kinases; Region: PKc; cd00180 324057008551 active site 324057008552 ATP binding site [chemical binding]; other site 324057008553 substrate binding site [chemical binding]; other site 324057008554 activation loop (A-loop); other site 324057008555 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057008556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057008557 active site 324057008558 phosphorylation site [posttranslational modification] 324057008559 intermolecular recognition site; other site 324057008560 dimerization interface [polypeptide binding]; other site 324057008561 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057008562 DNA binding site [nucleotide binding] 324057008563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057008564 HAMP domain; Region: HAMP; pfam00672 324057008565 dimerization interface [polypeptide binding]; other site 324057008566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057008567 dimer interface [polypeptide binding]; other site 324057008568 phosphorylation site [posttranslational modification] 324057008569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057008570 ATP binding site [chemical binding]; other site 324057008571 Mg2+ binding site [ion binding]; other site 324057008572 G-X-G motif; other site 324057008573 Predicted amidohydrolase [General function prediction only]; Region: COG0388 324057008574 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 324057008575 putative active site [active] 324057008576 catalytic triad [active] 324057008577 putative dimer interface [polypeptide binding]; other site 324057008578 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057008579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057008580 Coenzyme A binding pocket [chemical binding]; other site 324057008581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 324057008582 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 324057008583 putative hydrolase; Provisional; Region: PRK02113 324057008584 MutS domain III; Region: MutS_III; pfam05192 324057008585 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057008586 Walker A/P-loop; other site 324057008587 ATP binding site [chemical binding]; other site 324057008588 Q-loop/lid; other site 324057008589 ABC transporter signature motif; other site 324057008590 Walker B; other site 324057008591 D-loop; other site 324057008592 H-loop/switch region; other site 324057008593 Thiamine pyrophosphokinase; Region: TPK; cd07995 324057008594 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 324057008595 active site 324057008596 dimerization interface [polypeptide binding]; other site 324057008597 thiamine binding site [chemical binding]; other site 324057008598 UPF0126 domain; Region: UPF0126; pfam03458 324057008599 Predicted membrane protein [Function unknown]; Region: COG2860 324057008600 UPF0126 domain; Region: UPF0126; pfam03458 324057008601 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 324057008602 Low molecular weight phosphatase family; Region: LMWPc; cd00115 324057008603 active site 324057008604 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 324057008605 Putative esterase; Region: Esterase; pfam00756 324057008606 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 324057008607 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 324057008608 TPP-binding site [chemical binding]; other site 324057008609 heterodimer interface [polypeptide binding]; other site 324057008610 tetramer interface [polypeptide binding]; other site 324057008611 phosphorylation loop region [posttranslational modification] 324057008612 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 324057008613 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 324057008614 alpha subunit interface [polypeptide binding]; other site 324057008615 TPP binding site [chemical binding]; other site 324057008616 heterodimer interface [polypeptide binding]; other site 324057008617 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 324057008618 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 324057008619 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 324057008620 E3 interaction surface; other site 324057008621 lipoyl attachment site [posttranslational modification]; other site 324057008622 e3 binding domain; Region: E3_binding; pfam02817 324057008623 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 324057008624 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 324057008625 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 324057008626 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057008627 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 324057008628 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 324057008629 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 324057008630 thymidylate synthase; Region: thym_sym; TIGR03284 324057008631 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 324057008632 dimerization interface [polypeptide binding]; other site 324057008633 active site 324057008634 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 324057008635 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 324057008636 folate binding site [chemical binding]; other site 324057008637 NADP+ binding site [chemical binding]; other site 324057008638 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 324057008639 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057008640 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 324057008641 DNA topoisomerase III; Provisional; Region: PRK07726 324057008642 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 324057008643 active site 324057008644 putative interdomain interaction site [polypeptide binding]; other site 324057008645 putative metal-binding site [ion binding]; other site 324057008646 putative nucleotide binding site [chemical binding]; other site 324057008647 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 324057008648 domain I; other site 324057008649 DNA binding groove [nucleotide binding] 324057008650 phosphate binding site [ion binding]; other site 324057008651 domain II; other site 324057008652 domain III; other site 324057008653 nucleotide binding site [chemical binding]; other site 324057008654 catalytic site [active] 324057008655 domain IV; other site 324057008656 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 324057008657 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 324057008658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057008659 motif II; other site 324057008660 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 324057008661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057008662 Walker A/P-loop; other site 324057008663 ATP binding site [chemical binding]; other site 324057008664 Q-loop/lid; other site 324057008665 ABC transporter signature motif; other site 324057008666 Walker B; other site 324057008667 D-loop; other site 324057008668 H-loop/switch region; other site 324057008669 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 324057008670 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057008671 Coenzyme A binding pocket [chemical binding]; other site 324057008672 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 324057008673 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 324057008674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 324057008675 MOSC domain; Region: MOSC; pfam03473 324057008676 3-alpha domain; Region: 3-alpha; pfam03475 324057008677 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 324057008678 Phosphotransferase enzyme family; Region: APH; pfam01636 324057008679 active site 324057008680 substrate binding site [chemical binding]; other site 324057008681 ATP binding site [chemical binding]; other site 324057008682 Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802 324057008683 putative active site [active] 324057008684 YdjC motif; other site 324057008685 Mg binding site [ion binding]; other site 324057008686 homodimer interface [polypeptide binding]; other site 324057008687 YcxB-like protein; Region: YcxB; pfam14317 324057008688 MoxR-like ATPases [General function prediction only]; Region: COG0714 324057008689 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 324057008690 Walker A motif; other site 324057008691 ATP binding site [chemical binding]; other site 324057008692 Walker B motif; other site 324057008693 arginine finger; other site 324057008694 Protein of unknown function DUF58; Region: DUF58; pfam01882 324057008695 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 324057008696 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 324057008697 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 324057008698 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057008699 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057008700 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324057008701 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 324057008702 Walker A/P-loop; other site 324057008703 ATP binding site [chemical binding]; other site 324057008704 Q-loop/lid; other site 324057008705 ABC transporter signature motif; other site 324057008706 Walker B; other site 324057008707 D-loop; other site 324057008708 H-loop/switch region; other site 324057008709 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057008710 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324057008711 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 324057008712 Walker A/P-loop; other site 324057008713 ATP binding site [chemical binding]; other site 324057008714 Q-loop/lid; other site 324057008715 ABC transporter signature motif; other site 324057008716 Walker B; other site 324057008717 D-loop; other site 324057008718 H-loop/switch region; other site 324057008719 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 324057008720 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 324057008721 active site 324057008722 DNA binding site [nucleotide binding] 324057008723 Int/Topo IB signature motif; other site 324057008724 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 324057008725 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 324057008726 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 324057008727 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 324057008728 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324057008729 active site 324057008730 dimer interface [polypeptide binding]; other site 324057008731 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 324057008732 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057008733 active site 324057008734 metal binding site [ion binding]; metal-binding site 324057008735 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 324057008736 S-layer homology domain; Region: SLH; pfam00395 324057008737 S-layer homology domain; Region: SLH; pfam00395 324057008738 S-layer homology domain; Region: SLH; pfam00395 324057008739 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 324057008740 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 324057008741 putative assembly protein; Region: PHA00350 324057008742 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 324057008743 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 324057008744 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 324057008745 Walker A/P-loop; other site 324057008746 ATP binding site [chemical binding]; other site 324057008747 Q-loop/lid; other site 324057008748 ABC transporter signature motif; other site 324057008749 Walker B; other site 324057008750 D-loop; other site 324057008751 H-loop/switch region; other site 324057008752 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 324057008753 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 324057008754 Walker A/P-loop; other site 324057008755 ATP binding site [chemical binding]; other site 324057008756 Q-loop/lid; other site 324057008757 ABC transporter signature motif; other site 324057008758 Walker B; other site 324057008759 D-loop; other site 324057008760 H-loop/switch region; other site 324057008761 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 324057008762 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 324057008763 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057008764 Coenzyme A binding pocket [chemical binding]; other site 324057008765 LysE type translocator; Region: LysE; pfam01810 324057008766 Uncharacterized conserved protein [Function unknown]; Region: COG2353 324057008767 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 324057008768 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 324057008769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057008770 Coenzyme A binding pocket [chemical binding]; other site 324057008771 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057008772 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057008773 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057008774 dimerization interface [polypeptide binding]; other site 324057008775 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 324057008776 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 324057008777 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 324057008778 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 324057008779 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 324057008780 TPP-binding site [chemical binding]; other site 324057008781 dimer interface [polypeptide binding]; other site 324057008782 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 324057008783 PYR/PP interface [polypeptide binding]; other site 324057008784 dimer interface [polypeptide binding]; other site 324057008785 TPP binding site [chemical binding]; other site 324057008786 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 324057008787 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 324057008788 active site 324057008789 intersubunit interactions; other site 324057008790 catalytic residue [active] 324057008791 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 324057008792 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 324057008793 nudix motif; other site 324057008794 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 324057008795 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 324057008796 Chromate transporter; Region: Chromate_transp; pfam02417 324057008797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057008798 Coenzyme A binding pocket [chemical binding]; other site 324057008799 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 324057008800 substrate binding site [chemical binding]; other site 324057008801 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 324057008802 short chain dehydrogenase; Provisional; Region: PRK06924 324057008803 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057008804 NAD(P) binding site [chemical binding]; other site 324057008805 active site 324057008806 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324057008807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057008808 S-adenosylmethionine binding site [chemical binding]; other site 324057008809 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 324057008810 nudix motif; other site 324057008811 DinB superfamily; Region: DinB_2; pfam12867 324057008812 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 324057008813 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 324057008814 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057008815 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 324057008816 active site 324057008817 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 324057008818 dimer interface [polypeptide binding]; other site 324057008819 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057008820 ligand binding site [chemical binding]; other site 324057008821 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 324057008822 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 324057008823 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 324057008824 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057008825 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 324057008826 ATP binding site [chemical binding]; other site 324057008827 putative Mg++ binding site [ion binding]; other site 324057008828 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057008829 nucleotide binding region [chemical binding]; other site 324057008830 ATP-binding site [chemical binding]; other site 324057008831 DEAD/H associated; Region: DEAD_assoc; pfam08494 324057008832 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057008833 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324057008834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057008835 Walker A/P-loop; other site 324057008836 ATP binding site [chemical binding]; other site 324057008837 Q-loop/lid; other site 324057008838 ABC transporter signature motif; other site 324057008839 Walker B; other site 324057008840 D-loop; other site 324057008841 H-loop/switch region; other site 324057008842 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057008843 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324057008844 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 324057008845 Walker A/P-loop; other site 324057008846 ATP binding site [chemical binding]; other site 324057008847 Q-loop/lid; other site 324057008848 ABC transporter signature motif; other site 324057008849 Walker B; other site 324057008850 D-loop; other site 324057008851 H-loop/switch region; other site 324057008852 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057008853 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 324057008854 active site 324057008855 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 324057008856 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057008857 FeS/SAM binding site; other site 324057008858 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 324057008859 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 324057008860 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 324057008861 putative Cl- selectivity filter; other site 324057008862 putative pore gating glutamate residue; other site 324057008863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057008864 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057008865 Coenzyme A binding pocket [chemical binding]; other site 324057008866 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 324057008867 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 324057008868 putative oligomer interface [polypeptide binding]; other site 324057008869 putative active site [active] 324057008870 metal binding site [ion binding]; metal-binding site 324057008871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 324057008872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057008873 ATP binding site [chemical binding]; other site 324057008874 Mg2+ binding site [ion binding]; other site 324057008875 G-X-G motif; other site 324057008876 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057008877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057008878 active site 324057008879 phosphorylation site [posttranslational modification] 324057008880 intermolecular recognition site; other site 324057008881 dimerization interface [polypeptide binding]; other site 324057008882 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057008883 DNA binding residues [nucleotide binding] 324057008884 dimerization interface [polypeptide binding]; other site 324057008885 DoxX-like family; Region: DoxX_3; pfam13781 324057008886 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 324057008887 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 324057008888 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057008889 Zn2+ binding site [ion binding]; other site 324057008890 Mg2+ binding site [ion binding]; other site 324057008891 Response regulator receiver domain; Region: Response_reg; pfam00072 324057008892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057008893 active site 324057008894 phosphorylation site [posttranslational modification] 324057008895 intermolecular recognition site; other site 324057008896 dimerization interface [polypeptide binding]; other site 324057008897 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 324057008898 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057008899 metal binding site [ion binding]; metal-binding site 324057008900 active site 324057008901 I-site; other site 324057008902 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 324057008903 GAF domain; Region: GAF_3; pfam13492 324057008904 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 324057008905 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324057008906 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057008907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057008908 dimer interface [polypeptide binding]; other site 324057008909 phosphorylation site [posttranslational modification] 324057008910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057008911 ATP binding site [chemical binding]; other site 324057008912 G-X-G motif; other site 324057008913 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 324057008914 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 324057008915 PYR/PP interface [polypeptide binding]; other site 324057008916 dimer interface [polypeptide binding]; other site 324057008917 TPP binding site [chemical binding]; other site 324057008918 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 324057008919 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 324057008920 TPP-binding site [chemical binding]; other site 324057008921 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 324057008922 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 324057008923 active site 324057008924 metal binding site [ion binding]; metal-binding site 324057008925 catalytic site [active] 324057008926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057008927 benzoate transport; Region: 2A0115; TIGR00895 324057008928 putative substrate translocation pore; other site 324057008929 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057008930 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057008931 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057008932 Spore germination protein; Region: Spore_permease; cl17796 324057008933 ParB-like nuclease domain; Region: ParBc; pfam02195 324057008934 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057008935 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 324057008936 putative NAD(P) binding site [chemical binding]; other site 324057008937 active site 324057008938 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057008939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057008940 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 324057008941 putative substrate translocation pore; other site 324057008942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057008943 Predicted transcriptional regulators [Transcription]; Region: COG1695 324057008944 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 324057008945 Bacterial SH3 domain; Region: SH3_3; pfam08239 324057008946 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 324057008947 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057008948 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]; Region: RPN7; COG5187 324057008949 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 324057008950 VanW like protein; Region: VanW; pfam04294 324057008951 translocation protein TolB; Provisional; Region: tolB; PRK02889 324057008952 Domain of unknown function (DUF718); Region: DUF718; pfam05336 324057008953 cell division protein GpsB; Provisional; Region: PRK14127 324057008954 DivIVA domain; Region: DivI1A_domain; TIGR03544 324057008955 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 324057008956 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 324057008957 ATP binding site [chemical binding]; other site 324057008958 Mg++ binding site [ion binding]; other site 324057008959 motif III; other site 324057008960 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057008961 nucleotide binding region [chemical binding]; other site 324057008962 ATP-binding site [chemical binding]; other site 324057008963 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 324057008964 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 324057008965 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324057008966 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324057008967 ABC transporter; Region: ABC_tran_2; pfam12848 324057008968 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324057008969 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 324057008970 Beta-lactamase; Region: Beta-lactamase; pfam00144 324057008971 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 324057008972 Beta-lactamase; Region: Beta-lactamase; pfam00144 324057008973 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 324057008974 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 324057008975 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 324057008976 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057008977 Walker A/P-loop; other site 324057008978 ATP binding site [chemical binding]; other site 324057008979 Q-loop/lid; other site 324057008980 ABC transporter signature motif; other site 324057008981 Walker B; other site 324057008982 D-loop; other site 324057008983 H-loop/switch region; other site 324057008984 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 324057008985 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324057008986 DNA binding residues [nucleotide binding] 324057008987 dimer interface [polypeptide binding]; other site 324057008988 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 324057008989 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 324057008990 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 324057008991 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 324057008992 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 324057008993 dimer interface [polypeptide binding]; other site 324057008994 active site 324057008995 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 324057008996 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 324057008997 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 324057008998 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 324057008999 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 324057009000 active site 324057009001 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 324057009002 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 324057009003 tetramer interface [polypeptide binding]; other site 324057009004 active site 324057009005 Mg2+/Mn2+ binding site [ion binding]; other site 324057009006 Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108 324057009007 dimer interface [polypeptide binding]; other site 324057009008 Citrate synthase; Region: Citrate_synt; pfam00285 324057009009 active site 324057009010 citrylCoA binding site [chemical binding]; other site 324057009011 oxalacetate/citrate binding site [chemical binding]; other site 324057009012 coenzyme A binding site [chemical binding]; other site 324057009013 catalytic triad [active] 324057009014 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 324057009015 2-methylcitrate dehydratase; Region: prpD; TIGR02330 324057009016 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 324057009017 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324057009018 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324057009019 ABC transporter; Region: ABC_tran_2; pfam12848 324057009020 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324057009021 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 324057009022 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 324057009023 MOSC domain; Region: MOSC; pfam03473 324057009024 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 324057009025 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 324057009026 metal-binding site [ion binding] 324057009027 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324057009028 Soluble P-type ATPase [General function prediction only]; Region: COG4087 324057009029 hypothetical protein; Provisional; Region: PRK12378 324057009030 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057009031 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057009032 active site 324057009033 catalytic tetrad [active] 324057009034 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057009035 extended (e) SDRs; Region: SDR_e; cd08946 324057009036 NAD(P) binding site [chemical binding]; other site 324057009037 active site 324057009038 substrate binding site [chemical binding]; other site 324057009039 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 324057009040 EamA-like transporter family; Region: EamA; pfam00892 324057009041 hypothetical protein; Provisional; Region: PRK07758 324057009042 VanZ like family; Region: VanZ; pfam04892 324057009043 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057009044 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057009045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009046 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057009047 putative substrate translocation pore; other site 324057009048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009049 Chorismate mutase type II; Region: CM_2; smart00830 324057009050 Spore germination protein; Region: Spore_permease; cl17796 324057009051 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057009052 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057009053 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057009054 Lysine efflux permease [General function prediction only]; Region: COG1279 324057009055 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 324057009056 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057009057 DNA-binding site [nucleotide binding]; DNA binding site 324057009058 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057009059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057009060 homodimer interface [polypeptide binding]; other site 324057009061 catalytic residue [active] 324057009062 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 324057009063 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 324057009064 catalytic triad [active] 324057009065 catalytic triad [active] 324057009066 oxyanion hole [active] 324057009067 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 324057009068 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057009069 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057009070 DNA binding residues [nucleotide binding] 324057009071 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 324057009072 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 324057009073 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 324057009074 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 324057009075 putative NAD(P) binding site [chemical binding]; other site 324057009076 active site 324057009077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057009078 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 324057009079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057009080 dimer interface [polypeptide binding]; other site 324057009081 conserved gate region; other site 324057009082 putative PBP binding loops; other site 324057009083 ABC-ATPase subunit interface; other site 324057009084 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 324057009085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057009086 dimer interface [polypeptide binding]; other site 324057009087 conserved gate region; other site 324057009088 ABC-ATPase subunit interface; other site 324057009089 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 324057009090 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 324057009091 Walker A/P-loop; other site 324057009092 ATP binding site [chemical binding]; other site 324057009093 Q-loop/lid; other site 324057009094 ABC transporter signature motif; other site 324057009095 Walker B; other site 324057009096 D-loop; other site 324057009097 H-loop/switch region; other site 324057009098 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 324057009099 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324057009100 substrate binding pocket [chemical binding]; other site 324057009101 membrane-bound complex binding site; other site 324057009102 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 324057009103 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 324057009104 active site 324057009105 metal binding site [ion binding]; metal-binding site 324057009106 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 324057009107 amino acid transporter; Region: 2A0306; TIGR00909 324057009108 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 324057009109 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 324057009110 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 324057009111 urea carboxylase; Region: urea_carbox; TIGR02712 324057009112 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 324057009113 ATP-grasp domain; Region: ATP-grasp_4; cl17255 324057009114 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 324057009115 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 324057009116 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 324057009117 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 324057009118 carboxyltransferase (CT) interaction site; other site 324057009119 biotinylation site [posttranslational modification]; other site 324057009120 allophanate hydrolase; Provisional; Region: PRK08186 324057009121 Amidase; Region: Amidase; cl11426 324057009122 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 324057009123 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 324057009124 active site 324057009125 DinB superfamily; Region: DinB_2; pfam12867 324057009126 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 324057009127 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 324057009128 MOSC domain; Region: MOSC; pfam03473 324057009129 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 324057009130 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 324057009131 Predicted flavoprotein [General function prediction only]; Region: COG0431 324057009132 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 324057009133 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 324057009134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 324057009135 Helix-turn-helix domain; Region: HTH_17; pfam12728 324057009136 PBP superfamily domain; Region: PBP_like; pfam12727 324057009137 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 324057009138 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 324057009139 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057009140 Spore germination protein; Region: Spore_permease; cl17796 324057009141 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057009142 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057009143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009144 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057009145 putative substrate translocation pore; other site 324057009146 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 324057009147 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 324057009148 Predicted ATPase [General function prediction only]; Region: COG3910 324057009149 ATP-binding cassette domain of non-transporter proteins; Region: ABC_Class2; cd03227 324057009150 Walker A/P-loop; other site 324057009151 ATP binding site [chemical binding]; other site 324057009152 Q-loop/lid; other site 324057009153 ABC transporter signature motif; other site 324057009154 Walker B; other site 324057009155 D-loop; other site 324057009156 H-loop/switch region; other site 324057009157 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 324057009158 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057009159 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057009160 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057009161 dimerization interface [polypeptide binding]; other site 324057009162 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 324057009163 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 324057009164 THF binding site; other site 324057009165 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 324057009166 substrate binding site [chemical binding]; other site 324057009167 THF binding site; other site 324057009168 zinc-binding site [ion binding]; other site 324057009169 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 324057009170 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057009171 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324057009172 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057009173 Walker A/P-loop; other site 324057009174 ATP binding site [chemical binding]; other site 324057009175 Q-loop/lid; other site 324057009176 ABC transporter signature motif; other site 324057009177 Walker B; other site 324057009178 D-loop; other site 324057009179 H-loop/switch region; other site 324057009180 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057009181 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057009182 Spore germination protein; Region: Spore_permease; cl17796 324057009183 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057009184 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 324057009185 beta-galactosidase; Region: BGL; TIGR03356 324057009186 Predicted membrane protein [Function unknown]; Region: COG2322 324057009187 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 324057009188 active site 324057009189 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 324057009190 putative metal binding site [ion binding]; other site 324057009191 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 324057009192 putative metal binding site [ion binding]; other site 324057009193 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 324057009194 putative metal binding site [ion binding]; other site 324057009195 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 324057009196 putative metal binding site [ion binding]; other site 324057009197 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 324057009198 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 324057009199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009200 putative substrate translocation pore; other site 324057009201 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057009202 putative DNA binding site [nucleotide binding]; other site 324057009203 dimerization interface [polypeptide binding]; other site 324057009204 putative Zn2+ binding site [ion binding]; other site 324057009205 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057009206 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057009207 DNA binding site [nucleotide binding] 324057009208 domain linker motif; other site 324057009209 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057009210 ligand binding site [chemical binding]; other site 324057009211 dimerization interface [polypeptide binding]; other site 324057009212 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057009213 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057009214 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057009215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057009216 dimer interface [polypeptide binding]; other site 324057009217 conserved gate region; other site 324057009218 putative PBP binding loops; other site 324057009219 ABC-ATPase subunit interface; other site 324057009220 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 324057009221 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 324057009222 active site 324057009223 PHP-associated; Region: PHP_C; pfam13263 324057009224 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 324057009225 HTH domain; Region: HTH_11; pfam08279 324057009226 WYL domain; Region: WYL; pfam13280 324057009227 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057009228 non-specific DNA binding site [nucleotide binding]; other site 324057009229 salt bridge; other site 324057009230 sequence-specific DNA binding site [nucleotide binding]; other site 324057009231 short chain dehydrogenase; Provisional; Region: PRK06197 324057009232 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 324057009233 putative NAD(P) binding site [chemical binding]; other site 324057009234 active site 324057009235 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057009236 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057009237 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324057009238 catalytic core [active] 324057009239 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057009240 active site 324057009241 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057009242 catalytic tetrad [active] 324057009243 S-layer homology domain; Region: SLH; pfam00395 324057009244 Bacterial Ig-like domain; Region: Big_5; pfam13205 324057009245 Bacterial Ig-like domain; Region: Big_5; pfam13205 324057009246 Bacterial Ig-like domain; Region: Big_5; pfam13205 324057009247 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057009248 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057009249 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057009250 Bacterial SH3 domain; Region: SH3_3; pfam08239 324057009251 Bacterial SH3 domain; Region: SH3_3; pfam08239 324057009252 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 324057009253 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 324057009254 active site 324057009255 metal binding site [ion binding]; metal-binding site 324057009256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057009257 S-adenosylmethionine binding site [chemical binding]; other site 324057009258 Sm and related proteins; Region: Sm_like; cl00259 324057009259 Sm1 motif; other site 324057009260 RNA binding site [nucleotide binding]; other site 324057009261 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 324057009262 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057009263 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 324057009264 active site 324057009265 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 324057009266 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 324057009267 Walker A/P-loop; other site 324057009268 ATP binding site [chemical binding]; other site 324057009269 Q-loop/lid; other site 324057009270 ABC transporter signature motif; other site 324057009271 Walker B; other site 324057009272 D-loop; other site 324057009273 H-loop/switch region; other site 324057009274 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 324057009275 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324057009276 substrate binding pocket [chemical binding]; other site 324057009277 membrane-bound complex binding site; other site 324057009278 hinge residues; other site 324057009279 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 324057009280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057009281 dimer interface [polypeptide binding]; other site 324057009282 conserved gate region; other site 324057009283 putative PBP binding loops; other site 324057009284 ABC-ATPase subunit interface; other site 324057009285 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 324057009286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057009287 dimer interface [polypeptide binding]; other site 324057009288 conserved gate region; other site 324057009289 putative PBP binding loops; other site 324057009290 ABC-ATPase subunit interface; other site 324057009291 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057009292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057009293 ATP binding site [chemical binding]; other site 324057009294 Mg2+ binding site [ion binding]; other site 324057009295 G-X-G motif; other site 324057009296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057009297 Response regulator receiver domain; Region: Response_reg; pfam00072 324057009298 active site 324057009299 phosphorylation site [posttranslational modification] 324057009300 intermolecular recognition site; other site 324057009301 dimerization interface [polypeptide binding]; other site 324057009302 YcbB domain; Region: YcbB; pfam08664 324057009303 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057009304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057009305 dimer interface [polypeptide binding]; other site 324057009306 conserved gate region; other site 324057009307 putative PBP binding loops; other site 324057009308 ABC-ATPase subunit interface; other site 324057009309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057009310 dimer interface [polypeptide binding]; other site 324057009311 putative PBP binding loops; other site 324057009312 ABC-ATPase subunit interface; other site 324057009313 hypothetical protein; Provisional; Region: PRK06851 324057009314 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 324057009315 active site 324057009316 germination protein YpeB; Region: spore_YpeB; TIGR02889 324057009317 Transcriptional regulators [Transcription]; Region: MarR; COG1846 324057009318 MarR family; Region: MarR_2; pfam12802 324057009319 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 324057009320 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324057009321 ABC transporter; Region: ABC_tran_2; pfam12848 324057009322 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324057009323 Beta-lactamase; Region: Beta-lactamase; pfam00144 324057009324 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 324057009325 Uncharacterized protein domain similar to Clostridium thermocellum 2751; Region: Cthe_2751_like; cd11743 324057009326 dimer interface [polypeptide binding]; other site 324057009327 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 324057009328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057009329 S-adenosylmethionine binding site [chemical binding]; other site 324057009330 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 324057009331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009332 putative substrate translocation pore; other site 324057009333 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057009334 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057009335 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057009336 dimerization interface [polypeptide binding]; other site 324057009337 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057009338 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057009339 DNA binding site [nucleotide binding] 324057009340 domain linker motif; other site 324057009341 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057009342 dimerization interface [polypeptide binding]; other site 324057009343 ligand binding site [chemical binding]; other site 324057009344 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324057009345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057009346 dimer interface [polypeptide binding]; other site 324057009347 conserved gate region; other site 324057009348 putative PBP binding loops; other site 324057009349 ABC-ATPase subunit interface; other site 324057009350 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 324057009351 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057009352 Walker A/P-loop; other site 324057009353 ATP binding site [chemical binding]; other site 324057009354 Q-loop/lid; other site 324057009355 ABC transporter signature motif; other site 324057009356 Walker B; other site 324057009357 D-loop; other site 324057009358 H-loop/switch region; other site 324057009359 TOBE domain; Region: TOBE_2; pfam08402 324057009360 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057009361 hypothetical protein; Provisional; Region: PRK11622 324057009362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057009363 dimer interface [polypeptide binding]; other site 324057009364 conserved gate region; other site 324057009365 putative PBP binding loops; other site 324057009366 ABC-ATPase subunit interface; other site 324057009367 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 324057009368 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 324057009369 active site 324057009370 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 324057009371 active site 324057009372 catalytic site [active] 324057009373 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 324057009374 metal binding site [ion binding]; metal-binding site 324057009375 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 324057009376 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 324057009377 PYR/PP interface [polypeptide binding]; other site 324057009378 dimer interface [polypeptide binding]; other site 324057009379 TPP binding site [chemical binding]; other site 324057009380 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 324057009381 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 324057009382 TPP-binding site [chemical binding]; other site 324057009383 dimer interface [polypeptide binding]; other site 324057009384 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 324057009385 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 324057009386 putative valine binding site [chemical binding]; other site 324057009387 dimer interface [polypeptide binding]; other site 324057009388 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 324057009389 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057009390 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057009391 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057009392 Spore germination protein; Region: Spore_permease; cl17796 324057009393 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 324057009394 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 324057009395 gating phenylalanine in ion channel; other site 324057009396 lysine transporter; Provisional; Region: PRK10836 324057009397 conserved repeat domain; Region: B_ant_repeat; TIGR01451 324057009398 conserved repeat domain; Region: B_ant_repeat; TIGR01451 324057009399 conserved repeat domain; Region: B_ant_repeat; TIGR01451 324057009400 conserved repeat domain; Region: B_ant_repeat; TIGR01451 324057009401 conserved repeat domain; Region: B_ant_repeat; TIGR01451 324057009402 Domain of unknown function DUF11; Region: DUF11; cl17728 324057009403 Domain of unknown function DUF11; Region: DUF11; cl17728 324057009404 conserved repeat domain; Region: B_ant_repeat; TIGR01451 324057009405 conserved repeat domain; Region: B_ant_repeat; TIGR01451 324057009406 conserved repeat domain; Region: B_ant_repeat; TIGR01451 324057009407 conserved repeat domain; Region: B_ant_repeat; TIGR01451 324057009408 Domain of unknown function DUF11; Region: DUF11; cl17728 324057009409 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057009410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009411 putative substrate translocation pore; other site 324057009412 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057009413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009414 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057009415 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009416 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057009417 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057009418 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057009419 Glucuronate isomerase; Region: UxaC; pfam02614 324057009420 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 324057009421 altronate oxidoreductase; Provisional; Region: PRK03643 324057009422 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 324057009423 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 324057009424 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 324057009425 galactarate dehydratase; Region: galactar-dH20; TIGR03248 324057009426 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 324057009427 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 324057009428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009429 putative substrate translocation pore; other site 324057009430 Transcriptional regulators [Transcription]; Region: FadR; COG2186 324057009431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057009432 DNA-binding site [nucleotide binding]; DNA binding site 324057009433 FCD domain; Region: FCD; pfam07729 324057009434 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 324057009435 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057009436 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057009437 DNA binding residues [nucleotide binding] 324057009438 Uncharacterized conserved protein [Function unknown]; Region: COG2128 324057009439 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 324057009440 H+ Antiporter protein; Region: 2A0121; TIGR00900 324057009441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009442 putative substrate translocation pore; other site 324057009443 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 324057009444 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 324057009445 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 324057009446 [2Fe-2S] cluster binding site [ion binding]; other site 324057009447 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057009448 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057009449 Isochorismatase family; Region: Isochorismatase; pfam00857 324057009450 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 324057009451 catalytic triad [active] 324057009452 conserved cis-peptide bond; other site 324057009453 drug efflux system protein MdtG; Provisional; Region: PRK09874 324057009454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009455 putative substrate translocation pore; other site 324057009456 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 324057009457 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 324057009458 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 324057009459 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 324057009460 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 324057009461 dimerization interface [polypeptide binding]; other site 324057009462 NAD binding site [chemical binding]; other site 324057009463 ligand binding site [chemical binding]; other site 324057009464 catalytic site [active] 324057009465 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 324057009466 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 324057009467 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 324057009468 Predicted transcriptional regulators [Transcription]; Region: COG1695 324057009469 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 324057009470 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 324057009471 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 324057009472 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 324057009473 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 324057009474 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 324057009475 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 324057009476 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 324057009477 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 324057009478 DNA binding site [nucleotide binding] 324057009479 active site 324057009480 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 324057009481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057009482 S-adenosylmethionine binding site [chemical binding]; other site 324057009483 Protein of unknown function, DUF606; Region: DUF606; pfam04657 324057009484 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 324057009485 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324057009486 ligand binding site [chemical binding]; other site 324057009487 flexible hinge region; other site 324057009488 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 324057009489 Protein of unknown function, DUF606; Region: DUF606; pfam04657 324057009490 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 324057009491 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 324057009492 Transglycosylase; Region: Transgly; pfam00912 324057009493 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 324057009494 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 324057009495 Dienelactone hydrolase family; Region: DLH; pfam01738 324057009496 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 324057009497 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324057009498 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324057009499 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 324057009500 Part of AAA domain; Region: AAA_19; pfam13245 324057009501 Family description; Region: UvrD_C_2; pfam13538 324057009502 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057009503 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057009504 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057009505 dimerization interface [polypeptide binding]; other site 324057009506 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 324057009507 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 324057009508 substrate binding pocket [chemical binding]; other site 324057009509 catalytic triad [active] 324057009510 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 324057009511 Isochorismatase family; Region: Isochorismatase; pfam00857 324057009512 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 324057009513 catalytic triad [active] 324057009514 conserved cis-peptide bond; other site 324057009515 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 324057009516 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 324057009517 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057009518 classical (c) SDRs; Region: SDR_c; cd05233 324057009519 NAD(P) binding site [chemical binding]; other site 324057009520 active site 324057009521 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 324057009522 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057009523 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 324057009524 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057009525 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 324057009526 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057009527 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057009528 Spore germination protein; Region: Spore_permease; cl17796 324057009529 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057009530 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057009531 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057009532 Rrf2 family protein; Region: rrf2_super; TIGR00738 324057009533 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057009534 putative DNA binding site [nucleotide binding]; other site 324057009535 putative Zn2+ binding site [ion binding]; other site 324057009536 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 324057009537 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 324057009538 Ion channel; Region: Ion_trans_2; pfam07885 324057009539 TrkA-N domain; Region: TrkA_N; pfam02254 324057009540 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324057009541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057009542 S-adenosylmethionine binding site [chemical binding]; other site 324057009543 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 324057009544 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 324057009545 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 324057009546 Cupin domain; Region: Cupin_2; pfam07883 324057009547 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057009548 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009549 Glycosyl hydrolase family 43; Region: GH43_2; cd08981 324057009550 active site 324057009551 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 324057009552 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057009553 dimerization interface [polypeptide binding]; other site 324057009554 Histidine kinase; Region: His_kinase; pfam06580 324057009555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057009556 ATP binding site [chemical binding]; other site 324057009557 Mg2+ binding site [ion binding]; other site 324057009558 G-X-G motif; other site 324057009559 Response regulator receiver domain; Region: Response_reg; pfam00072 324057009560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057009561 active site 324057009562 phosphorylation site [posttranslational modification] 324057009563 intermolecular recognition site; other site 324057009564 dimerization interface [polypeptide binding]; other site 324057009565 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057009566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009567 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057009568 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 324057009569 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057009570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057009571 dimer interface [polypeptide binding]; other site 324057009572 conserved gate region; other site 324057009573 putative PBP binding loops; other site 324057009574 ABC-ATPase subunit interface; other site 324057009575 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057009576 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057009577 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057009578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009579 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009580 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 324057009581 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 324057009582 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 324057009583 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 324057009584 heme binding pocket [chemical binding]; other site 324057009585 YolD-like protein; Region: YolD; pfam08863 324057009586 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057009587 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057009588 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057009589 dimerization interface [polypeptide binding]; other site 324057009590 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 324057009591 amidohydrolase; Region: amidohydrolases; TIGR01891 324057009592 metal binding site [ion binding]; metal-binding site 324057009593 Predicted membrane protein [Function unknown]; Region: COG1288 324057009594 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 324057009595 galactonate dehydratase; Provisional; Region: PRK14017 324057009596 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 324057009597 putative active site pocket [active] 324057009598 putative metal binding site [ion binding]; other site 324057009599 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 324057009600 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057009601 motif II; other site 324057009602 Right handed beta helix region; Region: Beta_helix; pfam13229 324057009603 beta-D-glucuronidase; Provisional; Region: PRK10150 324057009604 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324057009605 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057009606 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 324057009607 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057009608 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009609 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057009610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009611 Domain of unknown function DUF11; Region: DUF11; cl17728 324057009612 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 324057009613 Domain of unknown function DUF11; Region: DUF11; pfam01345 324057009614 Domain of unknown function DUF11; Region: DUF11; pfam01345 324057009615 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 324057009616 Domain of unknown function DUF11; Region: DUF11; cl17728 324057009617 Domain of unknown function DUF11; Region: DUF11; pfam01345 324057009618 Domain of unknown function DUF11; Region: DUF11; pfam01345 324057009619 Domain of unknown function DUF11; Region: DUF11; pfam01345 324057009620 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 324057009621 Domain of unknown function DUF11; Region: DUF11; pfam01345 324057009622 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057009623 dimerization interface [polypeptide binding]; other site 324057009624 putative DNA binding site [nucleotide binding]; other site 324057009625 putative Zn2+ binding site [ion binding]; other site 324057009626 cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662 324057009627 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 324057009628 NADP binding site [chemical binding]; other site 324057009629 putative substrate binding site [chemical binding]; other site 324057009630 active site 324057009631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057009632 Coenzyme A binding pocket [chemical binding]; other site 324057009633 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 324057009634 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 324057009635 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 324057009636 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 324057009637 metal-dependent hydrolase; Provisional; Region: PRK13291 324057009638 DinB superfamily; Region: DinB_2; pfam12867 324057009639 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 324057009640 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 324057009641 putative ligand binding site [chemical binding]; other site 324057009642 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 324057009643 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 324057009644 iron-sulfur cluster [ion binding]; other site 324057009645 [2Fe-2S] cluster binding site [ion binding]; other site 324057009646 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 324057009647 hydrophobic ligand binding site; other site 324057009648 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057009649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057009650 active site 324057009651 phosphorylation site [posttranslational modification] 324057009652 intermolecular recognition site; other site 324057009653 dimerization interface [polypeptide binding]; other site 324057009654 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057009655 DNA binding site [nucleotide binding] 324057009656 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057009657 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057009658 dimerization interface [polypeptide binding]; other site 324057009659 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057009660 dimer interface [polypeptide binding]; other site 324057009661 phosphorylation site [posttranslational modification] 324057009662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057009663 ATP binding site [chemical binding]; other site 324057009664 Mg2+ binding site [ion binding]; other site 324057009665 G-X-G motif; other site 324057009666 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 324057009667 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 324057009668 Uracil DNA glycosylase superfamily; Region: UDG; pfam03167 324057009669 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 324057009670 nucleotide binding site [chemical binding]; other site 324057009671 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324057009672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009673 putative substrate translocation pore; other site 324057009674 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057009675 Cupin domain; Region: Cupin_2; pfam07883 324057009676 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057009677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009678 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 324057009679 Glycosyl hydrolase family 43; Region: GH43_5; cd08984 324057009680 active site 324057009681 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 324057009682 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 324057009683 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057009684 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009685 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057009686 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009687 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 324057009688 SWIM zinc finger; Region: SWIM; pfam04434 324057009689 MoxR-like ATPases [General function prediction only]; Region: COG0714 324057009690 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 324057009691 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 324057009692 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 324057009693 metal ion-dependent adhesion site (MIDAS); other site 324057009694 stage V sporulation protein B; Region: spore_V_B; TIGR02900 324057009695 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 324057009696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057009697 binding surface 324057009698 TPR motif; other site 324057009699 Tetratrico peptide repeat; Region: TPR_5; pfam12688 324057009700 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057009701 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057009702 active site 324057009703 catalytic tetrad [active] 324057009704 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 324057009705 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057009706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057009707 active site 324057009708 phosphorylation site [posttranslational modification] 324057009709 intermolecular recognition site; other site 324057009710 dimerization interface [polypeptide binding]; other site 324057009711 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057009712 DNA binding site [nucleotide binding] 324057009713 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057009714 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057009715 dimerization interface [polypeptide binding]; other site 324057009716 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057009717 dimer interface [polypeptide binding]; other site 324057009718 phosphorylation site [posttranslational modification] 324057009719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057009720 ATP binding site [chemical binding]; other site 324057009721 Mg2+ binding site [ion binding]; other site 324057009722 G-X-G motif; other site 324057009723 short chain dehydrogenase; Provisional; Region: PRK06701 324057009724 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 324057009725 NAD binding site [chemical binding]; other site 324057009726 metal binding site [ion binding]; metal-binding site 324057009727 active site 324057009728 Domain of unknown function (DUF336); Region: DUF336; cl01249 324057009729 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 324057009730 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324057009731 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 324057009732 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 324057009733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057009734 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 324057009735 active site 324057009736 motif I; other site 324057009737 motif II; other site 324057009738 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 324057009739 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 324057009740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009741 putative substrate translocation pore; other site 324057009742 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 324057009743 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 324057009744 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 324057009745 oligomer interface [polypeptide binding]; other site 324057009746 active site residues [active] 324057009747 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 324057009748 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057009749 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 324057009750 DNA binding residues [nucleotide binding] 324057009751 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057009752 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057009753 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057009754 Spore germination protein; Region: Spore_permease; cl17796 324057009755 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 324057009756 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 324057009757 Predicted transcriptional regulators [Transcription]; Region: COG1733 324057009758 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 324057009759 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 324057009760 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 324057009761 phosphopeptide binding site; other site 324057009762 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057009763 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 324057009764 DNA binding site [nucleotide binding] 324057009765 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 324057009766 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 324057009767 hinge; other site 324057009768 active site 324057009769 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057009770 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057009771 Spore germination protein; Region: Spore_permease; cl17796 324057009772 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057009773 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057009774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057009775 short chain dehydrogenase; Provisional; Region: PRK06180 324057009776 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 324057009777 NADP binding site [chemical binding]; other site 324057009778 active site 324057009779 steroid binding site; other site 324057009780 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 324057009781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009782 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 324057009783 putative substrate translocation pore; other site 324057009784 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 324057009785 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 324057009786 active site 324057009787 DNA binding site [nucleotide binding] 324057009788 Int/Topo IB signature motif; other site 324057009789 Isochorismatase family; Region: Isochorismatase; pfam00857 324057009790 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 324057009791 catalytic triad [active] 324057009792 conserved cis-peptide bond; other site 324057009793 BNR repeat-like domain; Region: BNR_2; pfam13088 324057009794 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 324057009795 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 324057009796 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 324057009797 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057009798 ABC-ATPase subunit interface; other site 324057009799 dimer interface [polypeptide binding]; other site 324057009800 putative PBP binding regions; other site 324057009801 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 324057009802 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 324057009803 metal binding site [ion binding]; metal-binding site 324057009804 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 324057009805 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 324057009806 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 324057009807 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324057009808 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057009809 Coenzyme A binding pocket [chemical binding]; other site 324057009810 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 324057009811 putative hydrophobic ligand binding site [chemical binding]; other site 324057009812 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 324057009813 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057009814 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009815 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 324057009816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057009817 NAD(P) binding site [chemical binding]; other site 324057009818 active site 324057009819 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057009820 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057009821 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057009822 Spore germination protein; Region: Spore_permease; cl17796 324057009823 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057009824 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057009825 intersubunit interface [polypeptide binding]; other site 324057009826 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009827 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057009828 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009829 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057009830 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057009831 intersubunit interface [polypeptide binding]; other site 324057009832 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 324057009833 PAS domain S-box; Region: sensory_box; TIGR00229 324057009834 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057009835 putative active site [active] 324057009836 heme pocket [chemical binding]; other site 324057009837 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324057009838 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057009839 putative active site [active] 324057009840 heme pocket [chemical binding]; other site 324057009841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057009842 dimer interface [polypeptide binding]; other site 324057009843 phosphorylation site [posttranslational modification] 324057009844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057009845 ATP binding site [chemical binding]; other site 324057009846 Mg2+ binding site [ion binding]; other site 324057009847 G-X-G motif; other site 324057009848 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 324057009849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057009850 active site 324057009851 phosphorylation site [posttranslational modification] 324057009852 intermolecular recognition site; other site 324057009853 dimerization interface [polypeptide binding]; other site 324057009854 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324057009855 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057009856 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 324057009857 Protease prsW family; Region: PrsW-protease; pfam13367 324057009858 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 324057009859 oligomer interface [polypeptide binding]; other site 324057009860 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057009861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057009862 Coenzyme A binding pocket [chemical binding]; other site 324057009863 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 324057009864 active site 324057009865 ATP binding site [chemical binding]; other site 324057009866 amidase; Provisional; Region: PRK06828 324057009867 Amidase; Region: Amidase; cl11426 324057009868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009870 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057009871 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057009872 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057009873 dimerization interface [polypeptide binding]; other site 324057009874 DinB family; Region: DinB; cl17821 324057009875 DinB superfamily; Region: DinB_2; pfam12867 324057009876 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 324057009877 RNA/DNA hybrid binding site [nucleotide binding]; other site 324057009878 active site 324057009879 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057009880 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057009881 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057009882 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 324057009883 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 324057009884 Phosphotransferase enzyme family; Region: APH; pfam01636 324057009885 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 324057009886 active site 324057009887 ATP binding site [chemical binding]; other site 324057009888 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 324057009889 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057009890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057009891 active site 324057009892 phosphorylation site [posttranslational modification] 324057009893 intermolecular recognition site; other site 324057009894 dimerization interface [polypeptide binding]; other site 324057009895 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057009896 DNA binding site [nucleotide binding] 324057009897 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057009898 dimerization interface [polypeptide binding]; other site 324057009899 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057009900 dimer interface [polypeptide binding]; other site 324057009901 phosphorylation site [posttranslational modification] 324057009902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057009903 ATP binding site [chemical binding]; other site 324057009904 Mg2+ binding site [ion binding]; other site 324057009905 G-X-G motif; other site 324057009906 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057009907 dimerization interface [polypeptide binding]; other site 324057009908 putative DNA binding site [nucleotide binding]; other site 324057009909 putative Zn2+ binding site [ion binding]; other site 324057009910 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 324057009911 putative hydrophobic ligand binding site [chemical binding]; other site 324057009912 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057009913 Walker A/P-loop; other site 324057009914 ATP binding site [chemical binding]; other site 324057009915 Q-loop/lid; other site 324057009916 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 324057009917 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 324057009918 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057009919 Walker A/P-loop; other site 324057009920 ATP binding site [chemical binding]; other site 324057009921 Q-loop/lid; other site 324057009922 ABC transporter signature motif; other site 324057009923 Walker B; other site 324057009924 D-loop; other site 324057009925 H-loop/switch region; other site 324057009926 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057009927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057009928 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057009929 dimerization interface [polypeptide binding]; other site 324057009930 Spore germination protein; Region: Spore_permease; cl17796 324057009931 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057009932 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057009933 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057009934 Uncharacterized conserved protein [Function unknown]; Region: COG5646 324057009935 DinB family; Region: DinB; cl17821 324057009936 DinB superfamily; Region: DinB_2; pfam12867 324057009937 short chain dehydrogenase; Provisional; Region: PRK07062 324057009938 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057009939 NAD(P) binding site [chemical binding]; other site 324057009940 active site 324057009941 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057009942 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057009943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009944 putative substrate translocation pore; other site 324057009945 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057009946 Phosphotransferase enzyme family; Region: APH; pfam01636 324057009947 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 324057009948 active site 324057009949 substrate binding site [chemical binding]; other site 324057009950 ATP binding site [chemical binding]; other site 324057009951 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 324057009952 substrate binding site [chemical binding]; other site 324057009953 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 324057009954 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 324057009955 Beta/Gamma crystallin; Region: Crystall; cl02528 324057009956 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057009957 putative metal binding site [ion binding]; other site 324057009958 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057009959 putative metal binding site [ion binding]; other site 324057009960 EcsC protein family; Region: EcsC; pfam12787 324057009961 NIPSNAP; Region: NIPSNAP; pfam07978 324057009962 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 324057009963 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 324057009964 classical (c) SDRs; Region: SDR_c; cd05233 324057009965 NAD(P) binding site [chemical binding]; other site 324057009966 active site 324057009967 NIPSNAP; Region: NIPSNAP; pfam07978 324057009968 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 324057009969 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 324057009970 FMN binding site [chemical binding]; other site 324057009971 substrate binding site [chemical binding]; other site 324057009972 putative catalytic residue [active] 324057009973 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057009974 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057009975 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 324057009976 putative dimerization interface [polypeptide binding]; other site 324057009977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057009978 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057009979 putative substrate translocation pore; other site 324057009980 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057009981 Spore germination protein; Region: Spore_permease; cl17796 324057009982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 324057009983 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 324057009984 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057009985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057009986 active site 324057009987 phosphorylation site [posttranslational modification] 324057009988 intermolecular recognition site; other site 324057009989 dimerization interface [polypeptide binding]; other site 324057009990 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057009991 DNA binding site [nucleotide binding] 324057009992 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057009993 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057009994 dimerization interface [polypeptide binding]; other site 324057009995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057009996 dimer interface [polypeptide binding]; other site 324057009997 phosphorylation site [posttranslational modification] 324057009998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057009999 ATP binding site [chemical binding]; other site 324057010000 Mg2+ binding site [ion binding]; other site 324057010001 G-X-G motif; other site 324057010002 Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897 324057010003 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057010004 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057010005 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324057010006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057010007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057010008 putative PBP binding loops; other site 324057010009 dimer interface [polypeptide binding]; other site 324057010010 ABC-ATPase subunit interface; other site 324057010011 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057010012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057010013 dimer interface [polypeptide binding]; other site 324057010014 conserved gate region; other site 324057010015 putative PBP binding loops; other site 324057010016 ABC-ATPase subunit interface; other site 324057010017 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 324057010018 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 324057010019 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 324057010020 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 324057010021 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 324057010022 putative active site [active] 324057010023 catalytic site [active] 324057010024 putative metal binding site [ion binding]; other site 324057010025 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 324057010026 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 324057010027 active site 324057010028 HIGH motif; other site 324057010029 KMSKS motif; other site 324057010030 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 324057010031 tRNA binding surface [nucleotide binding]; other site 324057010032 anticodon binding site; other site 324057010033 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057010034 Spore germination protein; Region: Spore_permease; cl17796 324057010035 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057010036 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057010037 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 324057010038 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057010039 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 324057010040 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 324057010041 classical (c) SDRs; Region: SDR_c; cd05233 324057010042 NAD(P) binding site [chemical binding]; other site 324057010043 active site 324057010044 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057010045 MarR family; Region: MarR_2; pfam12802 324057010046 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 324057010047 classical (c) SDRs; Region: SDR_c; cd05233 324057010048 NAD(P) binding site [chemical binding]; other site 324057010049 active site 324057010050 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 324057010051 Uncharacterized conserved protein [Function unknown]; Region: COG2128 324057010052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057010053 NADH(P)-binding; Region: NAD_binding_10; pfam13460 324057010054 NAD(P) binding site [chemical binding]; other site 324057010055 active site 324057010056 methionine sulfoxide reductase A; Provisional; Region: PRK14054 324057010057 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 324057010058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057010059 ABC-ATPase subunit interface; other site 324057010060 putative PBP binding loops; other site 324057010061 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 324057010062 Erythromycin esterase; Region: Erythro_esteras; pfam05139 324057010063 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 324057010064 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057010065 FeS/SAM binding site; other site 324057010066 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 324057010067 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 324057010068 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057010069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010070 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057010071 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057010072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057010073 dimer interface [polypeptide binding]; other site 324057010074 conserved gate region; other site 324057010075 putative PBP binding loops; other site 324057010076 ABC-ATPase subunit interface; other site 324057010077 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057010078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057010079 dimer interface [polypeptide binding]; other site 324057010080 conserved gate region; other site 324057010081 putative PBP binding loops; other site 324057010082 ABC-ATPase subunit interface; other site 324057010083 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057010084 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057010085 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 324057010086 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057010087 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057010088 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057010089 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057010090 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 324057010091 Spore germination protein; Region: Spore_permease; cl17796 324057010092 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057010093 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057010094 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057010095 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 324057010096 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 324057010097 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 324057010098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057010099 Walker A/P-loop; other site 324057010100 ATP binding site [chemical binding]; other site 324057010101 Q-loop/lid; other site 324057010102 ABC transporter signature motif; other site 324057010103 Walker B; other site 324057010104 D-loop; other site 324057010105 H-loop/switch region; other site 324057010106 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324057010107 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 324057010108 active site 324057010109 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057010110 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057010111 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 324057010112 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 324057010113 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 324057010114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057010115 putative active site [active] 324057010116 heme pocket [chemical binding]; other site 324057010117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057010118 dimer interface [polypeptide binding]; other site 324057010119 phosphorylation site [posttranslational modification] 324057010120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057010121 ATP binding site [chemical binding]; other site 324057010122 Mg2+ binding site [ion binding]; other site 324057010123 G-X-G motif; other site 324057010124 CutC family; Region: CutC; cl01218 324057010125 phosphoenolpyruvate synthase; Validated; Region: PRK06241 324057010126 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 324057010127 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 324057010128 WYL domain; Region: WYL; cl14852 324057010129 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 324057010130 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 324057010131 dimerization interface [polypeptide binding]; other site 324057010132 DPS ferroxidase diiron center [ion binding]; other site 324057010133 ion pore; other site 324057010134 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 324057010135 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 324057010136 DEAD_2; Region: DEAD_2; pfam06733 324057010137 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 324057010138 Transcriptional regulators [Transcription]; Region: GntR; COG1802 324057010139 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057010140 DNA-binding site [nucleotide binding]; DNA binding site 324057010141 FCD domain; Region: FCD; pfam07729 324057010142 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 324057010143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 324057010144 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057010145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057010146 active site 324057010147 phosphorylation site [posttranslational modification] 324057010148 intermolecular recognition site; other site 324057010149 dimerization interface [polypeptide binding]; other site 324057010150 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057010151 DNA binding site [nucleotide binding] 324057010152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057010153 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057010154 dimerization interface [polypeptide binding]; other site 324057010155 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057010156 dimer interface [polypeptide binding]; other site 324057010157 phosphorylation site [posttranslational modification] 324057010158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057010159 ATP binding site [chemical binding]; other site 324057010160 Mg2+ binding site [ion binding]; other site 324057010161 G-X-G motif; other site 324057010162 Predicted membrane protein [Function unknown]; Region: COG2323 324057010163 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 324057010164 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 324057010165 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 324057010166 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 324057010167 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 324057010168 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 324057010169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057010170 NAD(P) binding site [chemical binding]; other site 324057010171 active site 324057010172 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 324057010173 substrate binding site [chemical binding]; other site 324057010174 catalytic residues [active] 324057010175 S-layer homology domain; Region: SLH; pfam00395 324057010176 S-layer homology domain; Region: SLH; pfam00395 324057010177 S-layer homology domain; Region: SLH; pfam00395 324057010178 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 324057010179 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057010180 DNA-binding site [nucleotide binding]; DNA binding site 324057010181 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057010182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057010183 homodimer interface [polypeptide binding]; other site 324057010184 catalytic residue [active] 324057010185 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 324057010186 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 324057010187 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057010188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057010189 dimer interface [polypeptide binding]; other site 324057010190 phosphorylation site [posttranslational modification] 324057010191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057010192 ATP binding site [chemical binding]; other site 324057010193 Mg2+ binding site [ion binding]; other site 324057010194 G-X-G motif; other site 324057010195 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG3056 324057010196 alpha-galactosidase; Region: PLN02808; cl17638 324057010197 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057010198 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 324057010199 putative active site [active] 324057010200 heme pocket [chemical binding]; other site 324057010201 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324057010202 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057010203 putative active site [active] 324057010204 heme pocket [chemical binding]; other site 324057010205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057010206 dimer interface [polypeptide binding]; other site 324057010207 phosphorylation site [posttranslational modification] 324057010208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057010209 ATP binding site [chemical binding]; other site 324057010210 Mg2+ binding site [ion binding]; other site 324057010211 G-X-G motif; other site 324057010212 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 324057010213 active site 324057010214 metal binding site [ion binding]; metal-binding site 324057010215 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057010216 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 324057010217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 324057010218 Cupin domain; Region: Cupin_2; pfam07883 324057010219 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057010220 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010221 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010222 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 324057010223 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057010224 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 324057010225 putative NAD(P) binding site [chemical binding]; other site 324057010226 active site 324057010227 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 324057010228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057010229 DNA-binding site [nucleotide binding]; DNA binding site 324057010230 FCD domain; Region: FCD; pfam07729 324057010231 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057010232 classical (c) SDRs; Region: SDR_c; cd05233 324057010233 NAD(P) binding site [chemical binding]; other site 324057010234 active site 324057010235 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 324057010236 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 324057010237 active site pocket [active] 324057010238 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 324057010239 Amidohydrolase; Region: Amidohydro_2; pfam04909 324057010240 active site 324057010241 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057010242 classical (c) SDRs; Region: SDR_c; cd05233 324057010243 NAD(P) binding site [chemical binding]; other site 324057010244 active site 324057010245 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 324057010246 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 324057010247 Predicted transcriptional regulators [Transcription]; Region: COG1733 324057010248 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057010249 dimerization interface [polypeptide binding]; other site 324057010250 putative DNA binding site [nucleotide binding]; other site 324057010251 putative Zn2+ binding site [ion binding]; other site 324057010252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057010253 NADH(P)-binding; Region: NAD_binding_10; pfam13460 324057010254 NAD(P) binding site [chemical binding]; other site 324057010255 active site 324057010256 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 324057010257 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057010258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057010259 active site 324057010260 phosphorylation site [posttranslational modification] 324057010261 intermolecular recognition site; other site 324057010262 dimerization interface [polypeptide binding]; other site 324057010263 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057010264 DNA binding site [nucleotide binding] 324057010265 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057010266 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057010267 dimerization interface [polypeptide binding]; other site 324057010268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057010269 dimer interface [polypeptide binding]; other site 324057010270 phosphorylation site [posttranslational modification] 324057010271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057010272 ATP binding site [chemical binding]; other site 324057010273 Mg2+ binding site [ion binding]; other site 324057010274 G-X-G motif; other site 324057010275 VanZ like family; Region: VanZ; pfam04892 324057010276 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 324057010277 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 324057010278 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324057010279 substrate binding pocket [chemical binding]; other site 324057010280 membrane-bound complex binding site; other site 324057010281 hinge residues; other site 324057010282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057010283 dimer interface [polypeptide binding]; other site 324057010284 conserved gate region; other site 324057010285 putative PBP binding loops; other site 324057010286 ABC-ATPase subunit interface; other site 324057010287 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 324057010288 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 324057010289 Walker A/P-loop; other site 324057010290 ATP binding site [chemical binding]; other site 324057010291 Q-loop/lid; other site 324057010292 ABC transporter signature motif; other site 324057010293 Walker B; other site 324057010294 D-loop; other site 324057010295 H-loop/switch region; other site 324057010296 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 324057010297 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 324057010298 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057010299 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010300 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 324057010301 HEAT repeats; Region: HEAT_2; pfam13646 324057010302 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 324057010303 protein binding surface [polypeptide binding]; other site 324057010304 HEAT repeats; Region: HEAT_2; pfam13646 324057010305 YtkA-like; Region: YtkA; pfam13115 324057010306 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 324057010307 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 324057010308 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 324057010309 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 324057010310 active site 324057010311 catalytic triad [active] 324057010312 oxyanion hole [active] 324057010313 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324057010314 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 324057010315 Walker A/P-loop; other site 324057010316 ATP binding site [chemical binding]; other site 324057010317 Q-loop/lid; other site 324057010318 ABC transporter signature motif; other site 324057010319 Walker B; other site 324057010320 D-loop; other site 324057010321 H-loop/switch region; other site 324057010322 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 324057010323 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 324057010324 SNF2 Helicase protein; Region: DUF3670; pfam12419 324057010325 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 324057010326 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057010327 ATP binding site [chemical binding]; other site 324057010328 putative Mg++ binding site [ion binding]; other site 324057010329 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057010330 nucleotide binding region [chemical binding]; other site 324057010331 ATP-binding site [chemical binding]; other site 324057010332 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 324057010333 active site 324057010334 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057010335 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057010336 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 324057010337 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057010338 intersubunit interface [polypeptide binding]; other site 324057010339 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057010340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010341 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057010342 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 324057010343 intersubunit interface [polypeptide binding]; other site 324057010344 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 324057010345 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 324057010346 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057010347 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057010348 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057010349 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057010350 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057010351 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057010352 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057010353 methionine sulfoxide reductase A; Provisional; Region: PRK14054 324057010354 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 324057010355 SelR domain; Region: SelR; pfam01641 324057010356 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 324057010357 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 324057010358 FMN binding site [chemical binding]; other site 324057010359 active site 324057010360 catalytic residues [active] 324057010361 substrate binding site [chemical binding]; other site 324057010362 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 324057010363 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057010364 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 324057010365 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057010366 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057010367 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057010368 dimerization interface [polypeptide binding]; other site 324057010369 putative deaminase; Validated; Region: PRK06846 324057010370 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 324057010371 active site 324057010372 putative deaminase; Validated; Region: PRK06846 324057010373 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 324057010374 active site 324057010375 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 324057010376 aspartate racemase; Region: asp_race; TIGR00035 324057010377 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057010378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057010379 active site 324057010380 phosphorylation site [posttranslational modification] 324057010381 intermolecular recognition site; other site 324057010382 dimerization interface [polypeptide binding]; other site 324057010383 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057010384 DNA binding site [nucleotide binding] 324057010385 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 324057010386 aspartate racemase; Region: asp_race; TIGR00035 324057010387 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 324057010388 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 324057010389 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 324057010390 acyl-activating enzyme (AAE) consensus motif; other site 324057010391 AMP binding site [chemical binding]; other site 324057010392 peptide maturation system acyl carrier-related protein; Region: ocin_ACP_rel; TIGR04069 324057010393 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 324057010394 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 324057010395 catalytic triad [active] 324057010396 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 324057010397 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 324057010398 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 324057010399 metal binding triad [ion binding]; metal-binding site 324057010400 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 324057010401 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057010402 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057010403 DNA binding site [nucleotide binding] 324057010404 domain linker motif; other site 324057010405 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057010406 dimerization interface [polypeptide binding]; other site 324057010407 ligand binding site [chemical binding]; other site 324057010408 Helix-turn-helix domain; Region: HTH_18; pfam12833 324057010409 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057010410 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057010411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057010412 dimer interface [polypeptide binding]; other site 324057010413 conserved gate region; other site 324057010414 ABC-ATPase subunit interface; other site 324057010415 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057010416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057010417 putative PBP binding loops; other site 324057010418 ABC-ATPase subunit interface; other site 324057010419 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057010420 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057010421 Sulfatase; Region: Sulfatase; cl17466 324057010422 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 324057010423 Sulfatase; Region: Sulfatase; cl17466 324057010424 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 324057010425 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 324057010426 N-acetyltransferase; Region: Acetyltransf_2; cl00949 324057010427 Cupin domain; Region: Cupin_2; cl17218 324057010428 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 324057010429 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 324057010430 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 324057010431 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 324057010432 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 324057010433 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 324057010434 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 324057010435 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 324057010436 dimer interface [polypeptide binding]; other site 324057010437 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 324057010438 Putative glucoamylase; Region: Glycoamylase; pfam10091 324057010439 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 324057010440 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 324057010441 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 324057010442 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 324057010443 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 324057010444 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057010445 MarR family; Region: MarR; pfam01047 324057010446 MarR family; Region: MarR_2; cl17246 324057010447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057010448 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057010449 putative substrate translocation pore; other site 324057010450 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057010451 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057010452 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057010453 dimerization interface [polypeptide binding]; other site 324057010454 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057010455 TPR motif; other site 324057010456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057010457 TPR motif; other site 324057010458 binding surface 324057010459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057010460 binding surface 324057010461 TPR motif; other site 324057010462 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 324057010463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057010464 Walker A motif; other site 324057010465 ATP binding site [chemical binding]; other site 324057010466 Walker B motif; other site 324057010467 arginine finger; other site 324057010468 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 324057010469 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 324057010470 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057010471 catalytic residue [active] 324057010472 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 324057010473 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 324057010474 NADP binding site [chemical binding]; other site 324057010475 homodimer interface [polypeptide binding]; other site 324057010476 active site 324057010477 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 324057010478 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 324057010479 active site 324057010480 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 324057010481 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 324057010482 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 324057010483 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057010484 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 324057010485 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 324057010486 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 324057010487 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057010488 active site 324057010489 metal binding site [ion binding]; metal-binding site 324057010490 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 324057010491 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057010492 active site 324057010493 metal binding site [ion binding]; metal-binding site 324057010494 homotetramer interface [polypeptide binding]; other site 324057010495 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057010496 dimerization interface [polypeptide binding]; other site 324057010497 putative DNA binding site [nucleotide binding]; other site 324057010498 putative Zn2+ binding site [ion binding]; other site 324057010499 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 324057010500 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 324057010501 dimer interface [polypeptide binding]; other site 324057010502 substrate binding site [chemical binding]; other site 324057010503 metal binding site [ion binding]; metal-binding site 324057010504 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 324057010505 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 324057010506 active site 324057010507 purine riboside binding site [chemical binding]; other site 324057010508 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 324057010509 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057010510 catalytic residue [active] 324057010511 allantoate amidohydrolase; Reviewed; Region: PRK09290 324057010512 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 324057010513 active site 324057010514 metal binding site [ion binding]; metal-binding site 324057010515 dimer interface [polypeptide binding]; other site 324057010516 allantoinase; Provisional; Region: PRK06189 324057010517 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 324057010518 active site 324057010519 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 324057010520 active site 324057010521 homotetramer interface [polypeptide binding]; other site 324057010522 Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648 324057010523 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 324057010524 active site 324057010525 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 324057010526 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 324057010527 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 324057010528 catalytic loop [active] 324057010529 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 324057010530 iron binding site [ion binding]; other site 324057010531 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 324057010532 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 324057010533 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 324057010534 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 324057010535 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 324057010536 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 324057010537 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 324057010538 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 324057010539 TM-ABC transporter signature motif; other site 324057010540 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 324057010541 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 324057010542 TM-ABC transporter signature motif; other site 324057010543 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 324057010544 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 324057010545 Walker A/P-loop; other site 324057010546 ATP binding site [chemical binding]; other site 324057010547 Q-loop/lid; other site 324057010548 ABC transporter signature motif; other site 324057010549 Walker B; other site 324057010550 D-loop; other site 324057010551 H-loop/switch region; other site 324057010552 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 324057010553 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 324057010554 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 324057010555 putative ligand binding site [chemical binding]; other site 324057010556 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 324057010557 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 324057010558 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 324057010559 XdhC Rossmann domain; Region: XdhC_C; pfam13478 324057010560 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 324057010561 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 324057010562 active site 324057010563 putative substrate binding pocket [chemical binding]; other site 324057010564 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 324057010565 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 324057010566 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057010567 Siphovirus protein of unknown function (DUF859); Region: DUF859; pfam05895 324057010568 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 324057010569 Beta-lactamase; Region: Beta-lactamase; pfam00144 324057010570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057010571 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057010572 putative substrate translocation pore; other site 324057010573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057010574 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 324057010575 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 324057010576 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 324057010577 Domain of unknown function DUF21; Region: DUF21; pfam01595 324057010578 gliding motility-associated protein GldE; Region: GldE; TIGR03520 324057010579 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 324057010580 Transporter associated domain; Region: CorC_HlyC; smart01091 324057010581 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 324057010582 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 324057010583 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 324057010584 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 324057010585 active site 324057010586 dimer interface [polypeptide binding]; other site 324057010587 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 324057010588 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 324057010589 Thioredoxin; Region: Thioredoxin_4; pfam13462 324057010590 Predicted membrane protein [Function unknown]; Region: COG3326 324057010591 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 324057010592 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057010593 ATP binding site [chemical binding]; other site 324057010594 putative Mg++ binding site [ion binding]; other site 324057010595 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057010596 nucleotide binding region [chemical binding]; other site 324057010597 ATP-binding site [chemical binding]; other site 324057010598 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 324057010599 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 324057010600 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 324057010601 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 324057010602 oligomer interface [polypeptide binding]; other site 324057010603 metal binding site [ion binding]; metal-binding site 324057010604 metal binding site [ion binding]; metal-binding site 324057010605 putative Cl binding site [ion binding]; other site 324057010606 aspartate ring; other site 324057010607 basic sphincter; other site 324057010608 hydrophobic gate; other site 324057010609 periplasmic entrance; other site 324057010610 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 324057010611 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 324057010612 active site 324057010613 HIGH motif; other site 324057010614 nucleotide binding site [chemical binding]; other site 324057010615 active site 324057010616 KMSKS motif; other site 324057010617 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 324057010618 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 324057010619 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057010620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057010621 homodimer interface [polypeptide binding]; other site 324057010622 catalytic residue [active] 324057010623 cobalamin synthase; Reviewed; Region: cobS; PRK00235 324057010624 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 324057010625 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 324057010626 homotrimer interface [polypeptide binding]; other site 324057010627 Walker A motif; other site 324057010628 GTP binding site [chemical binding]; other site 324057010629 Walker B motif; other site 324057010630 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 324057010631 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 324057010632 putative dimer interface [polypeptide binding]; other site 324057010633 active site pocket [active] 324057010634 putative cataytic base [active] 324057010635 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 324057010636 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 324057010637 Walker A/P-loop; other site 324057010638 ATP binding site [chemical binding]; other site 324057010639 Q-loop/lid; other site 324057010640 ABC transporter signature motif; other site 324057010641 Walker B; other site 324057010642 D-loop; other site 324057010643 H-loop/switch region; other site 324057010644 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057010645 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 324057010646 ABC-ATPase subunit interface; other site 324057010647 dimer interface [polypeptide binding]; other site 324057010648 putative PBP binding regions; other site 324057010649 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 324057010650 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057010651 putative binding site residues; other site 324057010652 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 324057010653 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 324057010654 metal-binding site [ion binding] 324057010655 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324057010656 Soluble P-type ATPase [General function prediction only]; Region: COG4087 324057010657 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 324057010658 active site residue [active] 324057010659 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 324057010660 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 324057010661 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 324057010662 VanW like protein; Region: VanW; pfam04294 324057010663 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 324057010664 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 324057010665 Catalytic site [active] 324057010666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057010667 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057010668 putative substrate translocation pore; other site 324057010669 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 324057010670 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 324057010671 Walker A/P-loop; other site 324057010672 ATP binding site [chemical binding]; other site 324057010673 Q-loop/lid; other site 324057010674 ABC transporter signature motif; other site 324057010675 Walker B; other site 324057010676 D-loop; other site 324057010677 H-loop/switch region; other site 324057010678 Cobalt transport protein; Region: CbiQ; cl00463 324057010679 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 324057010680 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 324057010681 Walker A/P-loop; other site 324057010682 ATP binding site [chemical binding]; other site 324057010683 Q-loop/lid; other site 324057010684 ABC transporter signature motif; other site 324057010685 Walker B; other site 324057010686 D-loop; other site 324057010687 H-loop/switch region; other site 324057010688 BioY family; Region: BioY; pfam02632 324057010689 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 324057010690 putative dimer interface [polypeptide binding]; other site 324057010691 catalytic triad [active] 324057010692 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 324057010693 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 324057010694 dimer interface [polypeptide binding]; other site 324057010695 active site 324057010696 metal binding site [ion binding]; metal-binding site 324057010697 Protein of unknown function (DUF964); Region: DUF964; cl01483 324057010698 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 324057010699 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 324057010700 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057010701 FeS/SAM binding site; other site 324057010702 TRAM domain; Region: TRAM; cl01282 324057010703 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 324057010704 Propanediol utilisation protein PduL; Region: PduL; pfam06130 324057010705 Propanediol utilisation protein PduL; Region: PduL; pfam06130 324057010706 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 324057010707 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 324057010708 TPP-binding site [chemical binding]; other site 324057010709 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 324057010710 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 324057010711 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 324057010712 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 324057010713 dimer interface [polypeptide binding]; other site 324057010714 PYR/PP interface [polypeptide binding]; other site 324057010715 TPP binding site [chemical binding]; other site 324057010716 substrate binding site [chemical binding]; other site 324057010717 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 324057010718 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 324057010719 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 324057010720 active site 324057010721 dimer interface [polypeptide binding]; other site 324057010722 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 324057010723 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 324057010724 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057010725 putative active site [active] 324057010726 metal binding site [ion binding]; metal-binding site 324057010727 homodimer binding site [polypeptide binding]; other site 324057010728 phosphodiesterase; Provisional; Region: PRK12704 324057010729 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057010730 Zn2+ binding site [ion binding]; other site 324057010731 Mg2+ binding site [ion binding]; other site 324057010732 RecX family; Region: RecX; cl00936 324057010733 recombinase A; Provisional; Region: recA; PRK09354 324057010734 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 324057010735 hexamer interface [polypeptide binding]; other site 324057010736 Walker A motif; other site 324057010737 ATP binding site [chemical binding]; other site 324057010738 Walker B motif; other site 324057010739 competence damage-inducible protein A; Provisional; Region: PRK00549 324057010740 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 324057010741 putative MPT binding site; other site 324057010742 Competence-damaged protein; Region: CinA; pfam02464 324057010743 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 324057010744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 324057010745 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 324057010746 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 324057010747 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057010748 non-specific DNA binding site [nucleotide binding]; other site 324057010749 salt bridge; other site 324057010750 sequence-specific DNA binding site [nucleotide binding]; other site 324057010751 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 324057010752 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 324057010753 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 324057010754 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057010755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057010756 NAD(P) binding site [chemical binding]; other site 324057010757 active site 324057010758 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 324057010759 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 324057010760 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 324057010761 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 324057010762 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 324057010763 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 324057010764 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 324057010765 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 324057010766 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 324057010767 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 324057010768 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 324057010769 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 324057010770 YlzJ-like protein; Region: YlzJ; pfam14035 324057010771 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 324057010772 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 324057010773 active site 324057010774 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 324057010775 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 324057010776 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 324057010777 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 324057010778 dihydrodipicolinate synthase; Region: dapA; TIGR00674 324057010779 dimer interface [polypeptide binding]; other site 324057010780 active site 324057010781 catalytic residue [active] 324057010782 aspartate kinase I; Reviewed; Region: PRK08210 324057010783 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 324057010784 nucleotide binding site [chemical binding]; other site 324057010785 substrate binding site [chemical binding]; other site 324057010786 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 324057010787 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 324057010788 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 324057010789 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 324057010790 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 324057010791 NAD binding site [chemical binding]; other site 324057010792 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 324057010793 trimer interface [polypeptide binding]; other site 324057010794 active site 324057010795 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 324057010796 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 324057010797 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 324057010798 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 324057010799 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 324057010800 NodB motif; other site 324057010801 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 324057010802 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 324057010803 RNase E interface [polypeptide binding]; other site 324057010804 trimer interface [polypeptide binding]; other site 324057010805 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 324057010806 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 324057010807 RNase E interface [polypeptide binding]; other site 324057010808 trimer interface [polypeptide binding]; other site 324057010809 active site 324057010810 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 324057010811 putative nucleic acid binding region [nucleotide binding]; other site 324057010812 G-X-X-G motif; other site 324057010813 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 324057010814 RNA binding site [nucleotide binding]; other site 324057010815 domain interface; other site 324057010816 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 324057010817 16S/18S rRNA binding site [nucleotide binding]; other site 324057010818 S13e-L30e interaction site [polypeptide binding]; other site 324057010819 25S rRNA binding site [nucleotide binding]; other site 324057010820 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 324057010821 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 324057010822 active site 324057010823 Riboflavin kinase; Region: Flavokinase; pfam01687 324057010824 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 324057010825 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 324057010826 RNA binding site [nucleotide binding]; other site 324057010827 active site 324057010828 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 324057010829 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 324057010830 DHH family; Region: DHH; pfam01368 324057010831 DHHA1 domain; Region: DHHA1; pfam02272 324057010832 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 324057010833 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 324057010834 translation initiation factor IF-2; Region: IF-2; TIGR00487 324057010835 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 324057010836 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 324057010837 G1 box; other site 324057010838 putative GEF interaction site [polypeptide binding]; other site 324057010839 GTP/Mg2+ binding site [chemical binding]; other site 324057010840 Switch I region; other site 324057010841 G2 box; other site 324057010842 G3 box; other site 324057010843 Switch II region; other site 324057010844 G5 box; other site 324057010845 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 324057010846 Translation-initiation factor 2; Region: IF-2; pfam11987 324057010847 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 324057010848 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 324057010849 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 324057010850 putative RNA binding cleft [nucleotide binding]; other site 324057010851 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 324057010852 NusA N-terminal domain; Region: NusA_N; pfam08529 324057010853 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 324057010854 RNA binding site [nucleotide binding]; other site 324057010855 homodimer interface [polypeptide binding]; other site 324057010856 NusA-like KH domain; Region: KH_5; pfam13184 324057010857 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 324057010858 G-X-X-G motif; other site 324057010859 ribosome maturation protein RimP; Reviewed; Region: PRK00092 324057010860 Sm and related proteins; Region: Sm_like; cl00259 324057010861 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 324057010862 putative oligomer interface [polypeptide binding]; other site 324057010863 putative RNA binding site [nucleotide binding]; other site 324057010864 DNA polymerase III PolC; Validated; Region: polC; PRK00448 324057010865 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 324057010866 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 324057010867 generic binding surface II; other site 324057010868 generic binding surface I; other site 324057010869 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 324057010870 active site 324057010871 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 324057010872 active site 324057010873 catalytic site [active] 324057010874 substrate binding site [chemical binding]; other site 324057010875 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 324057010876 prolyl-tRNA synthetase; Provisional; Region: PRK08661 324057010877 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 324057010878 dimer interface [polypeptide binding]; other site 324057010879 motif 1; other site 324057010880 active site 324057010881 motif 2; other site 324057010882 motif 3; other site 324057010883 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 324057010884 anticodon binding site; other site 324057010885 zinc-binding site [ion binding]; other site 324057010886 RIP metalloprotease RseP; Region: TIGR00054 324057010887 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 324057010888 active site 324057010889 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 324057010890 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 324057010891 protein binding site [polypeptide binding]; other site 324057010892 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 324057010893 putative substrate binding region [chemical binding]; other site 324057010894 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 324057010895 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 324057010896 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 324057010897 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 324057010898 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 324057010899 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 324057010900 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 324057010901 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 324057010902 catalytic residue [active] 324057010903 putative FPP diphosphate binding site; other site 324057010904 putative FPP binding hydrophobic cleft; other site 324057010905 dimer interface [polypeptide binding]; other site 324057010906 putative IPP diphosphate binding site; other site 324057010907 ribosome recycling factor; Reviewed; Region: frr; PRK00083 324057010908 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 324057010909 hinge region; other site 324057010910 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 324057010911 putative nucleotide binding site [chemical binding]; other site 324057010912 uridine monophosphate binding site [chemical binding]; other site 324057010913 homohexameric interface [polypeptide binding]; other site 324057010914 elongation factor Ts; Reviewed; Region: tsf; PRK12332 324057010915 UBA/TS-N domain; Region: UBA; pfam00627 324057010916 Elongation factor TS; Region: EF_TS; pfam00889 324057010917 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 324057010918 rRNA interaction site [nucleotide binding]; other site 324057010919 S8 interaction site; other site 324057010920 putative laminin-1 binding site; other site 324057010921 YceG-like family; Region: YceG; pfam02618 324057010922 Protein of unknown function (DUF342); Region: DUF342; pfam03961 324057010923 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 324057010924 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 324057010925 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057010926 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 324057010927 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057010928 DNA binding residues [nucleotide binding] 324057010929 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 324057010930 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 324057010931 putative CheA interaction surface; other site 324057010932 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 324057010933 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 324057010934 putative binding surface; other site 324057010935 active site 324057010936 P2 response regulator binding domain; Region: P2; pfam07194 324057010937 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 324057010938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057010939 ATP binding site [chemical binding]; other site 324057010940 Mg2+ binding site [ion binding]; other site 324057010941 G-X-G motif; other site 324057010942 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 324057010943 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 324057010944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057010945 active site 324057010946 phosphorylation site [posttranslational modification] 324057010947 intermolecular recognition site; other site 324057010948 dimerization interface [polypeptide binding]; other site 324057010949 CheB methylesterase; Region: CheB_methylest; pfam01339 324057010950 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 324057010951 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 324057010952 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 324057010953 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 324057010954 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 324057010955 FHIPEP family; Region: FHIPEP; pfam00771 324057010956 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 324057010957 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 324057010958 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 324057010959 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 324057010960 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 324057010961 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 324057010962 Response regulator receiver domain; Region: Response_reg; pfam00072 324057010963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057010964 active site 324057010965 phosphorylation site [posttranslational modification] 324057010966 intermolecular recognition site; other site 324057010967 dimerization interface [polypeptide binding]; other site 324057010968 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 324057010969 CheC-like family; Region: CheC; pfam04509 324057010970 CheC-like family; Region: CheC; pfam04509 324057010971 flagellar motor switch protein FliN; Region: fliN; TIGR02480 324057010972 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 324057010973 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 324057010974 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 324057010975 Flagellar protein (FlbD); Region: FlbD; pfam06289 324057010976 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 324057010977 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 324057010978 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 324057010979 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 324057010980 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 324057010981 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 324057010982 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 324057010983 Uncharacterized conserved protein [Function unknown]; Region: COG3334 324057010984 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 324057010985 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 324057010986 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 324057010987 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 324057010988 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 324057010989 Walker A motif/ATP binding site; other site 324057010990 Walker B motif; other site 324057010991 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 324057010992 Flagellar assembly protein FliH; Region: FliH; pfam02108 324057010993 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 324057010994 FliG C-terminal domain; Region: FliG_C; pfam01706 324057010995 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 324057010996 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 324057010997 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 324057010998 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 324057010999 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 324057011000 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 324057011001 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 324057011002 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 324057011003 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 324057011004 transcriptional repressor CodY; Validated; Region: PRK04158 324057011005 CodY GAF-like domain; Region: CodY; pfam06018 324057011006 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 324057011007 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 324057011008 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 324057011009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057011010 Walker A motif; other site 324057011011 ATP binding site [chemical binding]; other site 324057011012 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 324057011013 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 324057011014 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 324057011015 active site 324057011016 HslU subunit interaction site [polypeptide binding]; other site 324057011017 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 324057011018 Glucose inhibited division protein A; Region: GIDA; pfam01134 324057011019 DNA topoisomerase I; Validated; Region: PRK05582 324057011020 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 324057011021 active site 324057011022 interdomain interaction site; other site 324057011023 putative metal-binding site [ion binding]; other site 324057011024 nucleotide binding site [chemical binding]; other site 324057011025 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 324057011026 domain I; other site 324057011027 DNA binding groove [nucleotide binding] 324057011028 phosphate binding site [ion binding]; other site 324057011029 domain II; other site 324057011030 domain III; other site 324057011031 nucleotide binding site [chemical binding]; other site 324057011032 catalytic site [active] 324057011033 domain IV; other site 324057011034 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 324057011035 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 324057011036 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 324057011037 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 324057011038 DNA protecting protein DprA; Region: dprA; TIGR00732 324057011039 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 324057011040 CoA binding domain; Region: CoA_binding; smart00881 324057011041 CoA-ligase; Region: Ligase_CoA; pfam00549 324057011042 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 324057011043 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 324057011044 CoA-ligase; Region: Ligase_CoA; pfam00549 324057011045 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 324057011046 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 324057011047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057011048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 324057011049 Walker A motif; other site 324057011050 ATP binding site [chemical binding]; other site 324057011051 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 324057011052 hypothetical protein; Reviewed; Region: PRK12497 324057011053 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 324057011054 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 324057011055 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 324057011056 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 324057011057 RNA/DNA hybrid binding site [nucleotide binding]; other site 324057011058 active site 324057011059 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 324057011060 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 324057011061 GTP/Mg2+ binding site [chemical binding]; other site 324057011062 G4 box; other site 324057011063 G5 box; other site 324057011064 G1 box; other site 324057011065 Switch I region; other site 324057011066 G2 box; other site 324057011067 G3 box; other site 324057011068 Switch II region; other site 324057011069 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 324057011070 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 324057011071 Catalytic site [active] 324057011072 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 324057011073 C1q domain; Region: C1q; cl17543 324057011074 C1q domain; Region: C1q; cl17543 324057011075 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 324057011076 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 324057011077 RimM N-terminal domain; Region: RimM; pfam01782 324057011078 PRC-barrel domain; Region: PRC; pfam05239 324057011079 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 324057011080 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 324057011081 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 324057011082 signal recognition particle protein; Provisional; Region: PRK10867 324057011083 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 324057011084 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 324057011085 P loop; other site 324057011086 GTP binding site [chemical binding]; other site 324057011087 Signal peptide binding domain; Region: SRP_SPB; pfam02978 324057011088 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 324057011089 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057011090 DNA binding residues [nucleotide binding] 324057011091 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 324057011092 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 324057011093 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 324057011094 P loop; other site 324057011095 GTP binding site [chemical binding]; other site 324057011096 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 324057011097 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 324057011098 Walker A/P-loop; other site 324057011099 ATP binding site [chemical binding]; other site 324057011100 Q-loop/lid; other site 324057011101 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 324057011102 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 324057011103 ABC transporter signature motif; other site 324057011104 Walker B; other site 324057011105 D-loop; other site 324057011106 H-loop/switch region; other site 324057011107 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 324057011108 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 324057011109 dimerization interface [polypeptide binding]; other site 324057011110 active site 324057011111 metal binding site [ion binding]; metal-binding site 324057011112 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 324057011113 dsRNA binding site [nucleotide binding]; other site 324057011114 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 324057011115 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 324057011116 dimer interface [polypeptide binding]; other site 324057011117 active site 324057011118 acyl carrier protein; Provisional; Region: acpP; PRK00982 324057011119 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 324057011120 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 324057011121 NAD(P) binding site [chemical binding]; other site 324057011122 homotetramer interface [polypeptide binding]; other site 324057011123 homodimer interface [polypeptide binding]; other site 324057011124 active site 324057011125 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 324057011126 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 324057011127 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 324057011128 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 324057011129 dimer interface [polypeptide binding]; other site 324057011130 active site 324057011131 CoA binding pocket [chemical binding]; other site 324057011132 putative phosphate acyltransferase; Provisional; Region: PRK05331 324057011133 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 324057011134 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 324057011135 active site 2 [active] 324057011136 active site 1 [active] 324057011137 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 324057011138 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 324057011139 hypothetical protein; Provisional; Region: PRK13670 324057011140 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 324057011141 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 324057011142 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 324057011143 Nucleoside recognition; Region: Gate; pfam07670 324057011144 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 324057011145 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 324057011146 active site 324057011147 (T/H)XGH motif; other site 324057011148 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 324057011149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057011150 S-adenosylmethionine binding site [chemical binding]; other site 324057011151 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 324057011152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 324057011153 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 324057011154 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 324057011155 active site 324057011156 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324057011157 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 324057011158 Walker A/P-loop; other site 324057011159 ATP binding site [chemical binding]; other site 324057011160 Q-loop/lid; other site 324057011161 ABC transporter signature motif; other site 324057011162 Walker B; other site 324057011163 D-loop; other site 324057011164 H-loop/switch region; other site 324057011165 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057011166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011167 dimer interface [polypeptide binding]; other site 324057011168 conserved gate region; other site 324057011169 putative PBP binding loops; other site 324057011170 ABC-ATPase subunit interface; other site 324057011171 Uncharacterized conserved protein [Function unknown]; Region: COG0011 324057011172 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 324057011173 NMT1/THI5 like; Region: NMT1; pfam09084 324057011174 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324057011175 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057011176 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 324057011177 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 324057011178 NADP-binding site; other site 324057011179 homotetramer interface [polypeptide binding]; other site 324057011180 substrate binding site [chemical binding]; other site 324057011181 homodimer interface [polypeptide binding]; other site 324057011182 active site 324057011183 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 324057011184 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 324057011185 Substrate binding site; other site 324057011186 Cupin domain; Region: Cupin_2; cl17218 324057011187 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 324057011188 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 324057011189 Probable Catalytic site; other site 324057011190 metal-binding site 324057011191 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 324057011192 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057011193 active site 324057011194 Methyltransferase domain; Region: Methyltransf_24; pfam13578 324057011195 Protein of unknown function (DUF563); Region: DUF563; pfam04577 324057011196 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057011197 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 324057011198 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 324057011199 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057011200 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324057011201 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 324057011202 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 324057011203 putative trimer interface [polypeptide binding]; other site 324057011204 putative CoA binding site [chemical binding]; other site 324057011205 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 324057011206 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 324057011207 inhibitor-cofactor binding pocket; inhibition site 324057011208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057011209 catalytic residue [active] 324057011210 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 324057011211 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 324057011212 NADP-binding site; other site 324057011213 homotetramer interface [polypeptide binding]; other site 324057011214 substrate binding site [chemical binding]; other site 324057011215 homodimer interface [polypeptide binding]; other site 324057011216 active site 324057011217 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 324057011218 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 324057011219 active site 324057011220 FMN binding site [chemical binding]; other site 324057011221 substrate binding site [chemical binding]; other site 324057011222 3Fe-4S cluster binding site [ion binding]; other site 324057011223 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 324057011224 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 324057011225 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 324057011226 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324057011227 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 324057011228 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 324057011229 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 324057011230 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 324057011231 NADP binding site [chemical binding]; other site 324057011232 homodimer interface [polypeptide binding]; other site 324057011233 active site 324057011234 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 324057011235 Penicillinase repressor; Region: Pencillinase_R; cl17580 324057011236 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 324057011237 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 324057011238 putative Cl- selectivity filter; other site 324057011239 putative pore gating glutamate residue; other site 324057011240 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057011241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011242 dimer interface [polypeptide binding]; other site 324057011243 conserved gate region; other site 324057011244 putative PBP binding loops; other site 324057011245 ABC-ATPase subunit interface; other site 324057011246 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324057011247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011248 dimer interface [polypeptide binding]; other site 324057011249 conserved gate region; other site 324057011250 putative PBP binding loops; other site 324057011251 ABC-ATPase subunit interface; other site 324057011252 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057011253 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057011254 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057011255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057011256 active site 324057011257 phosphorylation site [posttranslational modification] 324057011258 intermolecular recognition site; other site 324057011259 dimerization interface [polypeptide binding]; other site 324057011260 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011261 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057011262 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057011263 dimerization interface [polypeptide binding]; other site 324057011264 Histidine kinase; Region: His_kinase; pfam06580 324057011265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057011266 ATP binding site [chemical binding]; other site 324057011267 Mg2+ binding site [ion binding]; other site 324057011268 G-X-G motif; other site 324057011269 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 324057011270 N- and C-terminal domain interface [polypeptide binding]; other site 324057011271 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 324057011272 active site 324057011273 putative catalytic site [active] 324057011274 metal binding site [ion binding]; metal-binding site 324057011275 ATP binding site [chemical binding]; other site 324057011276 carbohydrate binding site [chemical binding]; other site 324057011277 L-rhamnose isomerase; Provisional; Region: PRK01076 324057011278 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 324057011279 short chain dehydrogenase; Validated; Region: PRK08324 324057011280 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 324057011281 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 324057011282 putative NAD(P) binding site [chemical binding]; other site 324057011283 active site 324057011284 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057011285 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057011286 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057011287 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057011288 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057011289 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057011290 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011291 Transcriptional regulator [Transcription]; Region: IclR; COG1414 324057011292 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057011293 dimerization interface [polypeptide binding]; other site 324057011294 putative Zn2+ binding site [ion binding]; other site 324057011295 putative DNA binding site [nucleotide binding]; other site 324057011296 Bacterial transcriptional regulator; Region: IclR; pfam01614 324057011297 tyramine oxidase; Provisional; Region: tynA; PRK11504 324057011298 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 324057011299 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 324057011300 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 324057011301 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 324057011302 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 324057011303 Nitrogen regulatory protein P-II; Region: P-II; smart00938 324057011304 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 324057011305 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 324057011306 catalytic triad [active] 324057011307 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 324057011308 active site 324057011309 catalytic triad [active] 324057011310 oxyanion hole [active] 324057011311 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 324057011312 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 324057011313 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 324057011314 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 324057011315 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324057011316 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 324057011317 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 324057011318 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 324057011319 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057011320 metal binding site [ion binding]; metal-binding site 324057011321 ligand binding site [chemical binding]; other site 324057011322 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057011323 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057011324 Interdomain contacts; other site 324057011325 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057011326 Interdomain contacts; other site 324057011327 Cytokine receptor motif; other site 324057011328 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 324057011329 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 324057011330 S-layer homology domain; Region: SLH; pfam00395 324057011331 S-layer homology domain; Region: SLH; pfam00395 324057011332 S-layer homology domain; Region: SLH; pfam00395 324057011333 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057011334 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057011335 Spore germination protein; Region: Spore_permease; cl17796 324057011336 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057011337 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 324057011338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057011339 S-adenosylmethionine binding site [chemical binding]; other site 324057011340 alpha-galactosidase; Region: PLN02808; cl17638 324057011341 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057011342 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057011343 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011344 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 324057011345 AAA ATPase domain; Region: AAA_16; pfam13191 324057011346 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 324057011347 TPR motif; other site 324057011348 binding surface 324057011349 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057011350 DNA binding residues [nucleotide binding] 324057011351 dimerization interface [polypeptide binding]; other site 324057011352 Kelch motif; Region: Kelch_1; pfam01344 324057011353 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 324057011354 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 324057011355 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 324057011356 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 324057011357 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 324057011358 S-layer homology domain; Region: SLH; pfam00395 324057011359 S-layer homology domain; Region: SLH; pfam00395 324057011360 S-layer homology domain; Region: SLH; pfam00395 324057011361 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057011362 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057011363 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011364 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011365 Family description; Region: VCBS; pfam13517 324057011366 Family description; Region: VCBS; pfam13517 324057011367 Family description; Region: VCBS; pfam13517 324057011368 Family description; Region: VCBS; pfam13517 324057011369 Family description; Region: VCBS; pfam13517 324057011370 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057011371 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057011372 Beta-lactamase; Region: Beta-lactamase; pfam00144 324057011373 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 324057011374 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 324057011375 Amidohydrolase; Region: Amidohydro_2; pfam04909 324057011376 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 324057011377 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 324057011378 putative NAD(P) binding site [chemical binding]; other site 324057011379 catalytic Zn binding site [ion binding]; other site 324057011380 structural Zn binding site [ion binding]; other site 324057011381 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057011382 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057011383 active site 324057011384 catalytic tetrad [active] 324057011385 Cupin domain; Region: Cupin_2; pfam07883 324057011386 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057011387 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011389 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 324057011390 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057011391 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057011392 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011393 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011394 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 324057011395 active site 324057011396 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057011397 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057011398 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011399 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011400 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 324057011401 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324057011402 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057011403 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 324057011404 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 324057011405 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 324057011406 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057011407 motif II; other site 324057011408 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 324057011409 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 324057011410 inhibitor site; inhibition site 324057011411 active site 324057011412 dimer interface [polypeptide binding]; other site 324057011413 catalytic residue [active] 324057011414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 324057011415 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 324057011416 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057011417 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 324057011418 active site 324057011419 motif I; other site 324057011420 motif II; other site 324057011421 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 324057011422 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057011423 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057011424 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 324057011425 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 324057011426 putative NAD(P) binding site [chemical binding]; other site 324057011427 catalytic Zn binding site [ion binding]; other site 324057011428 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057011429 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057011430 DNA binding site [nucleotide binding] 324057011431 domain linker motif; other site 324057011432 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057011433 dimerization interface [polypeptide binding]; other site 324057011434 ligand binding site [chemical binding]; other site 324057011435 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057011436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011437 dimer interface [polypeptide binding]; other site 324057011438 conserved gate region; other site 324057011439 putative PBP binding loops; other site 324057011440 ABC-ATPase subunit interface; other site 324057011441 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324057011442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011443 dimer interface [polypeptide binding]; other site 324057011444 conserved gate region; other site 324057011445 putative PBP binding loops; other site 324057011446 ABC-ATPase subunit interface; other site 324057011447 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057011448 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057011449 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 324057011450 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057011451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057011452 homodimer interface [polypeptide binding]; other site 324057011453 catalytic residue [active] 324057011454 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 324057011455 benzoate transporter; Region: benE; TIGR00843 324057011456 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 324057011457 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 324057011458 N- and C-terminal domain interface [polypeptide binding]; other site 324057011459 active site 324057011460 catalytic site [active] 324057011461 metal binding site [ion binding]; metal-binding site 324057011462 carbohydrate binding site [chemical binding]; other site 324057011463 ATP binding site [chemical binding]; other site 324057011464 fructuronate transporter; Provisional; Region: PRK10034; cl15264 324057011465 GntP family permease; Region: GntP_permease; pfam02447 324057011466 Response regulator receiver domain; Region: Response_reg; pfam00072 324057011467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057011468 active site 324057011469 phosphorylation site [posttranslational modification] 324057011470 intermolecular recognition site; other site 324057011471 dimerization interface [polypeptide binding]; other site 324057011472 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057011473 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011474 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057011475 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057011476 dimerization interface [polypeptide binding]; other site 324057011477 Histidine kinase; Region: His_kinase; pfam06580 324057011478 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057011479 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057011480 Predicted transcriptional regulator [Transcription]; Region: COG4189 324057011481 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057011482 dimerization interface [polypeptide binding]; other site 324057011483 putative DNA binding site [nucleotide binding]; other site 324057011484 putative Zn2+ binding site [ion binding]; other site 324057011485 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 324057011486 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 324057011487 Spore germination protein; Region: Spore_permease; cl17796 324057011488 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057011489 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057011490 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057011491 Epoxide hydrolase N terminus; Region: EHN; pfam06441 324057011492 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 324057011493 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057011494 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011495 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 324057011496 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057011497 intersubunit interface [polypeptide binding]; other site 324057011498 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057011499 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057011500 intersubunit interface [polypeptide binding]; other site 324057011501 Glycosyl hydrolase family 43; Region: GH43_5; cd08984 324057011502 active site 324057011503 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057011504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011505 dimer interface [polypeptide binding]; other site 324057011506 conserved gate region; other site 324057011507 putative PBP binding loops; other site 324057011508 ABC-ATPase subunit interface; other site 324057011509 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057011510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011511 dimer interface [polypeptide binding]; other site 324057011512 conserved gate region; other site 324057011513 putative PBP binding loops; other site 324057011514 ABC-ATPase subunit interface; other site 324057011515 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057011516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057011517 active site 324057011518 phosphorylation site [posttranslational modification] 324057011519 intermolecular recognition site; other site 324057011520 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057011521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011522 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057011523 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057011524 Histidine kinase; Region: His_kinase; pfam06580 324057011525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057011526 ATP binding site [chemical binding]; other site 324057011527 Mg2+ binding site [ion binding]; other site 324057011528 G-X-G motif; other site 324057011529 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057011530 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 324057011531 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; smart00813 324057011532 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 324057011533 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057011534 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057011535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011536 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011537 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 324057011538 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 324057011539 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 324057011540 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 324057011541 sugar binding site [chemical binding]; other site 324057011542 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057011543 putative metal binding site [ion binding]; other site 324057011544 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057011545 sugar binding site [chemical binding]; other site 324057011546 CARDB; Region: CARDB; pfam07705 324057011547 CARDB; Region: CARDB; pfam07705 324057011548 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057011549 putative metal binding site [ion binding]; other site 324057011550 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 324057011551 Right handed beta helix region; Region: Beta_helix; pfam13229 324057011552 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 324057011553 cytosine deaminase; Provisional; Region: PRK05985 324057011554 active site 324057011555 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 324057011556 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 324057011557 Walker A/P-loop; other site 324057011558 ATP binding site [chemical binding]; other site 324057011559 Q-loop/lid; other site 324057011560 ABC transporter signature motif; other site 324057011561 Walker B; other site 324057011562 D-loop; other site 324057011563 H-loop/switch region; other site 324057011564 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 324057011565 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 324057011566 TM-ABC transporter signature motif; other site 324057011567 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 324057011568 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 324057011569 Walker A/P-loop; other site 324057011570 ATP binding site [chemical binding]; other site 324057011571 Q-loop/lid; other site 324057011572 ABC transporter signature motif; other site 324057011573 Walker B; other site 324057011574 D-loop; other site 324057011575 H-loop/switch region; other site 324057011576 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 324057011577 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 324057011578 TM-ABC transporter signature motif; other site 324057011579 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 324057011580 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 324057011581 cytosine deaminase; Provisional; Region: PRK05985 324057011582 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 324057011583 active site 324057011584 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 324057011585 DRTGG domain; Region: DRTGG; pfam07085 324057011586 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 324057011587 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 324057011588 cobyric acid synthase; Provisional; Region: PRK00784 324057011589 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 324057011590 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 324057011591 catalytic triad [active] 324057011592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057011593 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 324057011594 Walker A/P-loop; other site 324057011595 ATP binding site [chemical binding]; other site 324057011596 Q-loop/lid; other site 324057011597 ABC transporter signature motif; other site 324057011598 Walker B; other site 324057011599 D-loop; other site 324057011600 H-loop/switch region; other site 324057011601 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057011602 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 324057011603 Walker A/P-loop; other site 324057011604 ATP binding site [chemical binding]; other site 324057011605 Q-loop/lid; other site 324057011606 ABC transporter signature motif; other site 324057011607 Walker B; other site 324057011608 D-loop; other site 324057011609 H-loop/switch region; other site 324057011610 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 324057011611 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 324057011612 putative active site [active] 324057011613 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 324057011614 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 324057011615 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 324057011616 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 324057011617 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 324057011618 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 324057011619 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 324057011620 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057011621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011622 dimer interface [polypeptide binding]; other site 324057011623 conserved gate region; other site 324057011624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057011625 ABC-ATPase subunit interface; other site 324057011626 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057011627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011628 dimer interface [polypeptide binding]; other site 324057011629 conserved gate region; other site 324057011630 ABC-ATPase subunit interface; other site 324057011631 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057011632 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057011633 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057011634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057011635 active site 324057011636 phosphorylation site [posttranslational modification] 324057011637 intermolecular recognition site; other site 324057011638 dimerization interface [polypeptide binding]; other site 324057011639 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011640 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057011641 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011642 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057011643 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057011644 dimerization interface [polypeptide binding]; other site 324057011645 Histidine kinase; Region: His_kinase; pfam06580 324057011646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057011647 ATP binding site [chemical binding]; other site 324057011648 Mg2+ binding site [ion binding]; other site 324057011649 G-X-G motif; other site 324057011650 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 324057011651 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 324057011652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 324057011653 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 324057011654 Propionate catabolism activator; Region: PrpR_N; pfam06506 324057011655 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 324057011656 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057011657 Walker A motif; other site 324057011658 ATP binding site [chemical binding]; other site 324057011659 Walker B motif; other site 324057011660 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 324057011661 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 324057011662 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011663 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057011664 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 324057011665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057011666 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 324057011667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 324057011668 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 324057011669 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011670 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057011671 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011672 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 324057011673 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057011674 active site 324057011675 ATP binding site [chemical binding]; other site 324057011676 substrate binding site [chemical binding]; other site 324057011677 putative metal dependent hydrolase; Provisional; Region: PRK11598 324057011678 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 324057011679 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057011680 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057011681 Coenzyme A binding pocket [chemical binding]; other site 324057011682 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 324057011683 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057011684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011685 dimer interface [polypeptide binding]; other site 324057011686 conserved gate region; other site 324057011687 putative PBP binding loops; other site 324057011688 ABC-ATPase subunit interface; other site 324057011689 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057011690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011691 ABC-ATPase subunit interface; other site 324057011692 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057011693 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057011694 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057011695 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011696 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324057011697 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 324057011698 DNA binding residues [nucleotide binding] 324057011699 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057011700 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057011701 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057011702 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 324057011703 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 324057011704 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 324057011705 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 324057011706 active site 324057011707 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057011708 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057011709 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057011710 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057011711 DNA-binding site [nucleotide binding]; DNA binding site 324057011712 Transcriptional regulators [Transcription]; Region: FadR; COG2186 324057011713 FCD domain; Region: FCD; pfam07729 324057011714 Predicted transcriptional regulator [Transcription]; Region: COG4189 324057011715 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057011716 putative DNA binding site [nucleotide binding]; other site 324057011717 dimerization interface [polypeptide binding]; other site 324057011718 putative Zn2+ binding site [ion binding]; other site 324057011719 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 324057011720 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 324057011721 inhibitor binding site; inhibition site 324057011722 active site 324057011723 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 324057011724 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 324057011725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057011726 putative substrate translocation pore; other site 324057011727 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 324057011728 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057011729 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011730 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057011731 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011732 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057011733 dockerin binding interface; other site 324057011734 S-layer homology domain; Region: SLH; pfam00395 324057011735 S-layer homology domain; Region: SLH; pfam00395 324057011736 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 324057011737 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 324057011738 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057011739 metal binding site [ion binding]; metal-binding site 324057011740 ligand binding site [chemical binding]; other site 324057011741 Putative Ig domain; Region: He_PIG; pfam05345 324057011742 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057011743 dockerin binding interface; other site 324057011744 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 324057011745 Ca2+ binding site [ion binding]; other site 324057011746 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057011747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011748 dimer interface [polypeptide binding]; other site 324057011749 ABC-ATPase subunit interface; other site 324057011750 putative PBP binding loops; other site 324057011751 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057011752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011753 dimer interface [polypeptide binding]; other site 324057011754 conserved gate region; other site 324057011755 putative PBP binding loops; other site 324057011756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057011757 ABC-ATPase subunit interface; other site 324057011758 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057011759 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057011760 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057011761 Histidine kinase; Region: His_kinase; pfam06580 324057011762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 324057011763 ATP binding site [chemical binding]; other site 324057011764 Mg2+ binding site [ion binding]; other site 324057011765 G-X-G motif; other site 324057011766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057011767 Response regulator receiver domain; Region: Response_reg; pfam00072 324057011768 active site 324057011769 phosphorylation site [posttranslational modification] 324057011770 intermolecular recognition site; other site 324057011771 dimerization interface [polypeptide binding]; other site 324057011772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011773 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057011774 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011775 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324057011776 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057011777 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057011778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011779 putative PBP binding loops; other site 324057011780 dimer interface [polypeptide binding]; other site 324057011781 ABC-ATPase subunit interface; other site 324057011782 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057011783 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 324057011784 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057011785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057011786 active site 324057011787 phosphorylation site [posttranslational modification] 324057011788 intermolecular recognition site; other site 324057011789 dimerization interface [polypeptide binding]; other site 324057011790 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011791 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057011792 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057011793 dimerization interface [polypeptide binding]; other site 324057011794 Histidine kinase; Region: His_kinase; pfam06580 324057011795 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 324057011796 ATP binding site [chemical binding]; other site 324057011797 Mg2+ binding site [ion binding]; other site 324057011798 G-X-G motif; other site 324057011799 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057011800 classical (c) SDRs; Region: SDR_c; cd05233 324057011801 NAD(P) binding site [chemical binding]; other site 324057011802 active site 324057011803 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057011804 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057011805 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057011806 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057011807 active site 324057011808 catalytic tetrad [active] 324057011809 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 324057011810 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 324057011811 DNA binding residues [nucleotide binding] 324057011812 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 324057011813 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 324057011814 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 324057011815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057011816 putative substrate translocation pore; other site 324057011817 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 324057011818 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 324057011819 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 324057011820 putative NAD(P) binding site [chemical binding]; other site 324057011821 putative substrate binding site [chemical binding]; other site 324057011822 catalytic Zn binding site [ion binding]; other site 324057011823 structural Zn binding site [ion binding]; other site 324057011824 dimer interface [polypeptide binding]; other site 324057011825 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 324057011826 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057011827 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 324057011828 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 324057011829 Mg++ binding site [ion binding]; other site 324057011830 putative catalytic motif [active] 324057011831 putative substrate binding site [chemical binding]; other site 324057011832 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057011833 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057011834 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 324057011835 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057011836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011837 dimer interface [polypeptide binding]; other site 324057011838 conserved gate region; other site 324057011839 ABC-ATPase subunit interface; other site 324057011840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011841 dimer interface [polypeptide binding]; other site 324057011842 conserved gate region; other site 324057011843 putative PBP binding loops; other site 324057011844 ABC-ATPase subunit interface; other site 324057011845 Response regulator receiver domain; Region: Response_reg; pfam00072 324057011846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057011847 active site 324057011848 phosphorylation site [posttranslational modification] 324057011849 intermolecular recognition site; other site 324057011850 dimerization interface [polypeptide binding]; other site 324057011851 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011852 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057011853 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011854 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057011855 Cache domain; Region: Cache_1; pfam02743 324057011856 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057011857 dimerization interface [polypeptide binding]; other site 324057011858 Histidine kinase; Region: His_kinase; pfam06580 324057011859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057011860 ATP binding site [chemical binding]; other site 324057011861 Mg2+ binding site [ion binding]; other site 324057011862 G-X-G motif; other site 324057011863 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057011864 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057011865 DNA binding site [nucleotide binding] 324057011866 domain linker motif; other site 324057011867 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 324057011868 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 324057011869 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324057011870 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 324057011871 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057011872 Protein of unknown function (DUF464); Region: DUF464; pfam04327 324057011873 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057011874 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057011875 DNA binding site [nucleotide binding] 324057011876 domain linker motif; other site 324057011877 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057011878 ligand binding site [chemical binding]; other site 324057011879 dimerization interface [polypeptide binding]; other site 324057011880 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057011881 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 324057011882 active site 324057011883 motif I; other site 324057011884 motif II; other site 324057011885 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 324057011886 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324057011887 Walker A/P-loop; other site 324057011888 ATP binding site [chemical binding]; other site 324057011889 Q-loop/lid; other site 324057011890 ABC transporter signature motif; other site 324057011891 Walker B; other site 324057011892 D-loop; other site 324057011893 H-loop/switch region; other site 324057011894 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 324057011895 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 324057011896 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324057011897 Walker A/P-loop; other site 324057011898 ATP binding site [chemical binding]; other site 324057011899 Q-loop/lid; other site 324057011900 ABC transporter signature motif; other site 324057011901 Walker B; other site 324057011902 D-loop; other site 324057011903 H-loop/switch region; other site 324057011904 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324057011905 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 324057011906 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 324057011907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011908 dimer interface [polypeptide binding]; other site 324057011909 conserved gate region; other site 324057011910 putative PBP binding loops; other site 324057011911 ABC-ATPase subunit interface; other site 324057011912 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 324057011913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011914 dimer interface [polypeptide binding]; other site 324057011915 conserved gate region; other site 324057011916 putative PBP binding loops; other site 324057011917 ABC-ATPase subunit interface; other site 324057011918 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 324057011919 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 324057011920 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057011921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011922 dimer interface [polypeptide binding]; other site 324057011923 conserved gate region; other site 324057011924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057011925 ABC-ATPase subunit interface; other site 324057011926 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057011927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011928 dimer interface [polypeptide binding]; other site 324057011929 conserved gate region; other site 324057011930 putative PBP binding loops; other site 324057011931 ABC-ATPase subunit interface; other site 324057011932 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057011933 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057011934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057011935 Response regulator receiver domain; Region: Response_reg; pfam00072 324057011936 active site 324057011937 phosphorylation site [posttranslational modification] 324057011938 intermolecular recognition site; other site 324057011939 dimerization interface [polypeptide binding]; other site 324057011940 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011941 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057011942 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011943 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057011944 dimerization interface [polypeptide binding]; other site 324057011945 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057011946 Histidine kinase; Region: His_kinase; pfam06580 324057011947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057011948 ATP binding site [chemical binding]; other site 324057011949 Mg2+ binding site [ion binding]; other site 324057011950 G-X-G motif; other site 324057011951 EamA-like transporter family; Region: EamA; pfam00892 324057011952 EamA-like transporter family; Region: EamA; pfam00892 324057011953 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057011954 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057011955 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057011956 dimerization interface [polypeptide binding]; other site 324057011957 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057011958 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057011959 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057011960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011961 dimer interface [polypeptide binding]; other site 324057011962 conserved gate region; other site 324057011963 ABC-ATPase subunit interface; other site 324057011964 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057011965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057011966 dimer interface [polypeptide binding]; other site 324057011967 conserved gate region; other site 324057011968 ABC-ATPase subunit interface; other site 324057011969 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057011970 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057011971 DNA polymerase IV; Reviewed; Region: PRK03103 324057011972 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 324057011973 active site 324057011974 DNA binding site [nucleotide binding] 324057011975 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 324057011976 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 324057011977 Uncharacterized conserved protein [Function unknown]; Region: COG2135 324057011978 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 324057011979 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 324057011980 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 324057011981 generic binding surface II; other site 324057011982 ssDNA binding site; other site 324057011983 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057011984 ATP binding site [chemical binding]; other site 324057011985 putative Mg++ binding site [ion binding]; other site 324057011986 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057011987 nucleotide binding region [chemical binding]; other site 324057011988 ATP-binding site [chemical binding]; other site 324057011989 EDD domain protein, DegV family; Region: DegV; TIGR00762 324057011990 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 324057011991 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 324057011992 DAK2 domain; Region: Dak2; pfam02734 324057011993 Asp23 family; Region: Asp23; pfam03780 324057011994 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 324057011995 Stage V sporulation protein family; Region: SpoV; cl15455 324057011996 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 324057011997 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 324057011998 substrate binding site [chemical binding]; other site 324057011999 hexamer interface [polypeptide binding]; other site 324057012000 metal binding site [ion binding]; metal-binding site 324057012001 GTPase RsgA; Reviewed; Region: PRK00098 324057012002 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 324057012003 RNA binding site [nucleotide binding]; other site 324057012004 homodimer interface [polypeptide binding]; other site 324057012005 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 324057012006 GTPase/Zn-binding domain interface [polypeptide binding]; other site 324057012007 GTP/Mg2+ binding site [chemical binding]; other site 324057012008 G4 box; other site 324057012009 G5 box; other site 324057012010 G1 box; other site 324057012011 Switch I region; other site 324057012012 G2 box; other site 324057012013 G3 box; other site 324057012014 Switch II region; other site 324057012015 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324057012016 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 324057012017 active site 324057012018 ATP binding site [chemical binding]; other site 324057012019 substrate binding site [chemical binding]; other site 324057012020 activation loop (A-loop); other site 324057012021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 324057012022 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 324057012023 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 324057012024 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 324057012025 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 324057012026 active site 324057012027 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 324057012028 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057012029 FeS/SAM binding site; other site 324057012030 NusB family; Region: NusB; pfam01029 324057012031 16S rRNA methyltransferase B; Provisional; Region: PRK14902 324057012032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057012033 S-adenosylmethionine binding site [chemical binding]; other site 324057012034 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 324057012035 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 324057012036 putative active site [active] 324057012037 substrate binding site [chemical binding]; other site 324057012038 putative cosubstrate binding site; other site 324057012039 catalytic site [active] 324057012040 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 324057012041 substrate binding site [chemical binding]; other site 324057012042 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 324057012043 active site 324057012044 catalytic residues [active] 324057012045 metal binding site [ion binding]; metal-binding site 324057012046 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057012047 primosomal protein N' Region: priA; TIGR00595 324057012048 ATP binding site [chemical binding]; other site 324057012049 putative Mg++ binding site [ion binding]; other site 324057012050 nucleotide binding region [chemical binding]; other site 324057012051 helicase superfamily c-terminal domain; Region: HELICc; smart00490 324057012052 ATP-binding site [chemical binding]; other site 324057012053 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 324057012054 Flavoprotein; Region: Flavoprotein; pfam02441 324057012055 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 324057012056 chaperone protein DnaJ; Provisional; Region: PRK14291 324057012057 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 324057012058 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 324057012059 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 324057012060 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 324057012061 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 324057012062 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 324057012063 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 324057012064 Cysteine-rich domain; Region: CCG; pfam02754 324057012065 Cysteine-rich domain; Region: CCG; pfam02754 324057012066 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324057012067 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 324057012068 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 324057012069 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 324057012070 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 324057012071 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 324057012072 catalytic site [active] 324057012073 G-X2-G-X-G-K; other site 324057012074 hypothetical protein; Provisional; Region: PRK04323 324057012075 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 324057012076 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 324057012077 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 324057012078 FAD binding site [chemical binding]; other site 324057012079 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 324057012080 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 324057012081 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 324057012082 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 324057012083 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 324057012084 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324057012085 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 324057012086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057012087 motif II; other site 324057012088 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 324057012089 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 324057012090 Domain of unknown function (DUF814); Region: DUF814; pfam05670 324057012091 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 324057012092 NlpC/P60 family; Region: NLPC_P60; cl17555 324057012093 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 324057012094 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 324057012095 active site 324057012096 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 324057012097 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057012098 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057012099 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 324057012100 putative dimerization interface [polypeptide binding]; other site 324057012101 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 324057012102 Protein of unknown function (DUF964); Region: DUF964; pfam06133 324057012103 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 324057012104 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 324057012105 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 324057012106 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057012107 ATP binding site [chemical binding]; other site 324057012108 putative Mg++ binding site [ion binding]; other site 324057012109 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057012110 nucleotide binding region [chemical binding]; other site 324057012111 ATP-binding site [chemical binding]; other site 324057012112 FOG: CBS domain [General function prediction only]; Region: COG0517 324057012113 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 324057012114 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 324057012115 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 324057012116 metal binding site [ion binding]; metal-binding site 324057012117 dimer interface [polypeptide binding]; other site 324057012118 YugN-like family; Region: YugN; pfam08868 324057012119 cell division protein FtsW; Region: ftsW; TIGR02614 324057012120 Asp23 family; Region: Asp23; pfam03780 324057012121 calcium/proton exchanger (cax); Region: cax; TIGR00378 324057012122 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 324057012123 hypothetical protein; Provisional; Region: PRK13666 324057012124 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 324057012125 regulatory protein interface [polypeptide binding]; other site 324057012126 regulatory phosphorylation site [posttranslational modification]; other site 324057012127 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 324057012128 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 324057012129 GAF domain; Region: GAF; cl17456 324057012130 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 324057012131 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324057012132 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 324057012133 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057012134 metal binding site [ion binding]; metal-binding site 324057012135 active site 324057012136 I-site; other site 324057012137 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 324057012138 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 324057012139 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324057012140 RNA binding surface [nucleotide binding]; other site 324057012141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057012142 S-adenosylmethionine binding site [chemical binding]; other site 324057012143 hypothetical protein; Provisional; Region: PHA02941 324057012144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 324057012145 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 324057012146 Transglycosylase; Region: Transgly; pfam00912 324057012147 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 324057012148 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 324057012149 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057012150 Interdomain contacts; other site 324057012151 Cytokine receptor motif; other site 324057012152 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057012153 Interdomain contacts; other site 324057012154 Cytokine receptor motif; other site 324057012155 acetyl-CoA synthetase; Provisional; Region: PRK04319 324057012156 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 324057012157 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 324057012158 acyl-activating enzyme (AAE) consensus motif; other site 324057012159 AMP binding site [chemical binding]; other site 324057012160 active site 324057012161 CoA binding site [chemical binding]; other site 324057012162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 324057012163 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 324057012164 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 324057012165 active site 324057012166 Zn binding site [ion binding]; other site 324057012167 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 324057012168 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 324057012169 catabolite control protein A; Region: ccpA; TIGR01481 324057012170 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057012171 DNA binding site [nucleotide binding] 324057012172 domain linker motif; other site 324057012173 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 324057012174 dimerization interface [polypeptide binding]; other site 324057012175 effector binding site; other site 324057012176 Predicted integral membrane protein [Function unknown]; Region: COG5652 324057012177 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 324057012178 proposed catalytic triad [active] 324057012179 conserved cys residue [active] 324057012180 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 324057012181 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 324057012182 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 324057012183 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 324057012184 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 324057012185 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 324057012186 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 324057012187 active site turn [active] 324057012188 phosphorylation site [posttranslational modification] 324057012189 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 324057012190 HPr interaction site; other site 324057012191 glycerol kinase (GK) interaction site [polypeptide binding]; other site 324057012192 active site 324057012193 phosphorylation site [posttranslational modification] 324057012194 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 324057012195 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 324057012196 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 324057012197 hinge; other site 324057012198 active site 324057012199 shikimate kinase; Reviewed; Region: aroK; PRK00131 324057012200 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 324057012201 ADP binding site [chemical binding]; other site 324057012202 magnesium binding site [ion binding]; other site 324057012203 putative shikimate binding site; other site 324057012204 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 324057012205 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 324057012206 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 324057012207 prolyl-tRNA synthetase; Provisional; Region: PRK09194 324057012208 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 324057012209 dimer interface [polypeptide binding]; other site 324057012210 motif 1; other site 324057012211 active site 324057012212 motif 2; other site 324057012213 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 324057012214 putative deacylase active site [active] 324057012215 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 324057012216 active site 324057012217 motif 3; other site 324057012218 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 324057012219 anticodon binding site; other site 324057012220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 324057012221 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 324057012222 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 324057012223 Protein export membrane protein; Region: SecD_SecF; cl14618 324057012224 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 324057012225 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 324057012226 Walker A/P-loop; other site 324057012227 ATP binding site [chemical binding]; other site 324057012228 Q-loop/lid; other site 324057012229 ABC transporter signature motif; other site 324057012230 Walker B; other site 324057012231 D-loop; other site 324057012232 H-loop/switch region; other site 324057012233 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 324057012234 ABC-2 type transporter; Region: ABC2_membrane; cl17235 324057012235 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057012236 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057012237 Uncharacterized conserved protein [Function unknown]; Region: COG1284 324057012238 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324057012239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057012240 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057012241 putative substrate translocation pore; other site 324057012242 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 324057012243 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 324057012244 homodimer interface [polypeptide binding]; other site 324057012245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057012246 catalytic residue [active] 324057012247 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 324057012248 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 324057012249 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 324057012250 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057012251 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057012252 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 324057012253 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 324057012254 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 324057012255 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 324057012256 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 324057012257 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 324057012258 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 324057012259 RNA polymerase sigma factor; Provisional; Region: PRK12519 324057012260 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057012261 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057012262 DNA binding residues [nucleotide binding] 324057012263 Putative zinc-finger; Region: zf-HC2; pfam13490 324057012264 putative anti-sigmaE protein; Provisional; Region: PRK13920 324057012265 Cupin domain; Region: Cupin_2; pfam07883 324057012266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057012267 Response regulator receiver domain; Region: Response_reg; pfam00072 324057012268 active site 324057012269 phosphorylation site [posttranslational modification] 324057012270 intermolecular recognition site; other site 324057012271 dimerization interface [polypeptide binding]; other site 324057012272 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057012273 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012274 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057012275 HAMP domain; Region: HAMP; pfam00672 324057012276 Histidine kinase; Region: His_kinase; pfam06580 324057012277 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 324057012278 Mg2+ binding site [ion binding]; other site 324057012279 G-X-G motif; other site 324057012280 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057012281 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057012282 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324057012283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012284 dimer interface [polypeptide binding]; other site 324057012285 conserved gate region; other site 324057012286 putative PBP binding loops; other site 324057012287 ABC-ATPase subunit interface; other site 324057012288 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057012289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012290 dimer interface [polypeptide binding]; other site 324057012291 conserved gate region; other site 324057012292 putative PBP binding loops; other site 324057012293 ABC-ATPase subunit interface; other site 324057012294 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 324057012295 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 324057012296 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324057012297 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 324057012298 Probable Catalytic site; other site 324057012299 metal-binding site 324057012300 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 324057012301 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 324057012302 substrate binding site; other site 324057012303 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 324057012304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057012305 NAD(P) binding site [chemical binding]; other site 324057012306 active site 324057012307 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 324057012308 Methyltransferase domain; Region: Methyltransf_23; pfam13489 324057012309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057012310 S-adenosylmethionine binding site [chemical binding]; other site 324057012311 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 324057012312 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 324057012313 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 324057012314 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 324057012315 trimer interface [polypeptide binding]; other site 324057012316 active site 324057012317 substrate binding site [chemical binding]; other site 324057012318 CoA binding site [chemical binding]; other site 324057012319 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 324057012320 extended (e) SDRs; Region: SDR_e; cd08946 324057012321 NAD(P) binding site [chemical binding]; other site 324057012322 active site 324057012323 substrate binding site [chemical binding]; other site 324057012324 PrcB C-terminal; Region: PrcB_C; pfam14343 324057012325 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 324057012326 ligand binding site [chemical binding]; other site 324057012327 active site 324057012328 UGI interface [polypeptide binding]; other site 324057012329 catalytic site [active] 324057012330 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 324057012331 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 324057012332 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 324057012333 active site 324057012334 RNA/DNA hybrid binding site [nucleotide binding]; other site 324057012335 hypothetical protein; Provisional; Region: PRK13679 324057012336 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 324057012337 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057012338 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057012339 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057012340 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 324057012341 Walker A/P-loop; other site 324057012342 ATP binding site [chemical binding]; other site 324057012343 Q-loop/lid; other site 324057012344 ABC transporter signature motif; other site 324057012345 Walker B; other site 324057012346 D-loop; other site 324057012347 H-loop/switch region; other site 324057012348 FtsX-like permease family; Region: FtsX; pfam02687 324057012349 FtsX-like permease family; Region: FtsX; pfam02687 324057012350 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 324057012351 HlyD family secretion protein; Region: HlyD_3; pfam13437 324057012352 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057012353 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 324057012354 Walker A/P-loop; other site 324057012355 ATP binding site [chemical binding]; other site 324057012356 Q-loop/lid; other site 324057012357 ABC transporter signature motif; other site 324057012358 Walker B; other site 324057012359 D-loop; other site 324057012360 H-loop/switch region; other site 324057012361 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057012362 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057012363 dimer interface [polypeptide binding]; other site 324057012364 putative CheW interface [polypeptide binding]; other site 324057012365 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057012366 active site 324057012367 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 324057012368 active site 324057012369 dimer interface [polypeptide binding]; other site 324057012370 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 324057012371 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 324057012372 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 324057012373 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 324057012374 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 324057012375 ATP-grasp domain; Region: ATP-grasp_4; cl17255 324057012376 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 324057012377 IMP binding site; other site 324057012378 dimer interface [polypeptide binding]; other site 324057012379 interdomain contacts; other site 324057012380 partial ornithine binding site; other site 324057012381 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 324057012382 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 324057012383 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 324057012384 catalytic site [active] 324057012385 subunit interface [polypeptide binding]; other site 324057012386 dihydroorotase; Validated; Region: pyrC; PRK09357 324057012387 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324057012388 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 324057012389 active site 324057012390 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 324057012391 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 324057012392 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 324057012393 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 324057012394 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057012395 active site 324057012396 aminotransferase A; Validated; Region: PRK07683 324057012397 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057012398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057012399 homodimer interface [polypeptide binding]; other site 324057012400 catalytic residue [active] 324057012401 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 324057012402 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 324057012403 metal binding site [ion binding]; metal-binding site 324057012404 putative dimer interface [polypeptide binding]; other site 324057012405 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 324057012406 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 324057012407 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 324057012408 active site 324057012409 trimer interface [polypeptide binding]; other site 324057012410 substrate binding site [chemical binding]; other site 324057012411 CoA binding site [chemical binding]; other site 324057012412 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 324057012413 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324057012414 RNA binding surface [nucleotide binding]; other site 324057012415 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 324057012416 active site 324057012417 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 324057012418 lipoprotein signal peptidase; Provisional; Region: PRK14787 324057012419 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 324057012420 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 324057012421 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 324057012422 HIGH motif; other site 324057012423 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 324057012424 active site 324057012425 KMSKS motif; other site 324057012426 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 324057012427 tRNA binding surface [nucleotide binding]; other site 324057012428 anticodon binding site; other site 324057012429 DivIVA protein; Region: DivIVA; pfam05103 324057012430 DivIVA domain; Region: DivI1A_domain; TIGR03544 324057012431 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 324057012432 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 324057012433 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324057012434 RNA binding surface [nucleotide binding]; other site 324057012435 YGGT family; Region: YGGT; pfam02325 324057012436 Protein of unknown function (DUF552); Region: DUF552; pfam04472 324057012437 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 324057012438 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 324057012439 catalytic residue [active] 324057012440 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 324057012441 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 324057012442 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 324057012443 sporulation sigma factor SigG; Reviewed; Region: PRK08215 324057012444 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057012445 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 324057012446 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057012447 DNA binding residues [nucleotide binding] 324057012448 sporulation sigma factor SigE; Reviewed; Region: PRK08301 324057012449 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057012450 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057012451 DNA binding residues [nucleotide binding] 324057012452 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 324057012453 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 324057012454 cell division protein FtsZ; Validated; Region: PRK09330 324057012455 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 324057012456 nucleotide binding site [chemical binding]; other site 324057012457 SulA interaction site; other site 324057012458 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 324057012459 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 324057012460 nucleotide binding site [chemical binding]; other site 324057012461 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 324057012462 Cell division protein FtsA; Region: FtsA; pfam14450 324057012463 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 324057012464 Cell division protein FtsQ; Region: FtsQ; pfam03799 324057012465 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 324057012466 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 324057012467 hinge; other site 324057012468 active site 324057012469 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 324057012470 FAD binding domain; Region: FAD_binding_4; pfam01565 324057012471 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 324057012472 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 324057012473 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 324057012474 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 324057012475 NAD binding site [chemical binding]; other site 324057012476 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324057012477 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324057012478 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 324057012479 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 324057012480 Mg++ binding site [ion binding]; other site 324057012481 putative catalytic motif [active] 324057012482 putative substrate binding site [chemical binding]; other site 324057012483 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 324057012484 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 324057012485 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324057012486 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324057012487 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 324057012488 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 324057012489 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324057012490 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324057012491 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 324057012492 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 324057012493 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 324057012494 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 324057012495 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 324057012496 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 324057012497 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 324057012498 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 324057012499 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 324057012500 MraW methylase family; Region: Methyltransf_5; pfam01795 324057012501 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 324057012502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 324057012503 MraZ protein; Region: MraZ; pfam02381 324057012504 MraZ protein; Region: MraZ; pfam02381 324057012505 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 324057012506 Arginase family; Region: Arginase; cd09989 324057012507 active site 324057012508 Mn binding site [ion binding]; other site 324057012509 oligomer interface [polypeptide binding]; other site 324057012510 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 324057012511 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324057012512 inhibitor-cofactor binding pocket; inhibition site 324057012513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057012514 catalytic residue [active] 324057012515 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 324057012516 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 324057012517 homotetramer interface [polypeptide binding]; other site 324057012518 ligand binding site [chemical binding]; other site 324057012519 catalytic site [active] 324057012520 NAD binding site [chemical binding]; other site 324057012521 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 324057012522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 324057012523 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 324057012524 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 324057012525 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 324057012526 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 324057012527 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 324057012528 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 324057012529 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 324057012530 Uncharacterized conserved protein [Function unknown]; Region: COG1565 324057012531 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 324057012532 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057012533 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 324057012534 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 324057012535 putative active site [active] 324057012536 PhoH-like protein; Region: PhoH; pfam02562 324057012537 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 324057012538 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 324057012539 Transcriptional regulator [Transcription]; Region: LytR; COG1316 324057012540 YlaH-like protein; Region: YlaH; pfam14036 324057012541 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 324057012542 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 324057012543 putative GEF interaction site [polypeptide binding]; other site 324057012544 G1 box; other site 324057012545 GTP/Mg2+ binding site [chemical binding]; other site 324057012546 Switch I region; other site 324057012547 G2 box; other site 324057012548 G3 box; other site 324057012549 Switch II region; other site 324057012550 G4 box; other site 324057012551 G5 box; other site 324057012552 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 324057012553 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 324057012554 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 324057012555 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 324057012556 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 324057012557 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 324057012558 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 324057012559 Ligand Binding Site [chemical binding]; other site 324057012560 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 324057012561 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 324057012562 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057012563 catalytic residue [active] 324057012564 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 324057012565 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 324057012566 N-acetyl-D-glucosamine binding site [chemical binding]; other site 324057012567 catalytic residue [active] 324057012568 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 324057012569 dimer interface [polypeptide binding]; other site 324057012570 FMN binding site [chemical binding]; other site 324057012571 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 324057012572 UbiA prenyltransferase family; Region: UbiA; pfam01040 324057012573 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 324057012574 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 324057012575 Walker A/P-loop; other site 324057012576 ATP binding site [chemical binding]; other site 324057012577 Q-loop/lid; other site 324057012578 ABC transporter signature motif; other site 324057012579 Walker B; other site 324057012580 D-loop; other site 324057012581 H-loop/switch region; other site 324057012582 Predicted transcriptional regulators [Transcription]; Region: COG1725 324057012583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057012584 DNA-binding site [nucleotide binding]; DNA binding site 324057012585 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 324057012586 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324057012587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057012588 Walker A/P-loop; other site 324057012589 ATP binding site [chemical binding]; other site 324057012590 Q-loop/lid; other site 324057012591 ABC transporter signature motif; other site 324057012592 Walker B; other site 324057012593 D-loop; other site 324057012594 H-loop/switch region; other site 324057012595 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057012596 dimer interface [polypeptide binding]; other site 324057012597 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 324057012598 putative CheW interface [polypeptide binding]; other site 324057012599 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 324057012600 aminotransferase; Validated; Region: PRK07678 324057012601 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324057012602 inhibitor-cofactor binding pocket; inhibition site 324057012603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057012604 catalytic residue [active] 324057012605 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 324057012606 nucleotide binding site/active site [active] 324057012607 HIT family signature motif; other site 324057012608 catalytic residue [active] 324057012609 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 324057012610 nudix motif; other site 324057012611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057012612 S-adenosylmethionine binding site [chemical binding]; other site 324057012613 sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678 324057012614 FAD binding domain; Region: FAD_binding_4; pfam01565 324057012615 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 324057012616 EDD domain protein, DegV family; Region: DegV; TIGR00762 324057012617 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 324057012618 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057012619 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057012620 sugar binding site [chemical binding]; other site 324057012621 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057012622 putative metal binding site [ion binding]; other site 324057012623 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057012624 putative metal binding site [ion binding]; other site 324057012625 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 324057012626 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 324057012627 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 324057012628 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 324057012629 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 324057012630 Predicted transcriptional regulators [Transcription]; Region: COG1725 324057012631 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057012632 DNA-binding site [nucleotide binding]; DNA binding site 324057012633 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 324057012634 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324057012635 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 324057012636 Walker A/P-loop; other site 324057012637 ATP binding site [chemical binding]; other site 324057012638 Q-loop/lid; other site 324057012639 ABC transporter signature motif; other site 324057012640 Walker B; other site 324057012641 D-loop; other site 324057012642 H-loop/switch region; other site 324057012643 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057012644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012645 dimer interface [polypeptide binding]; other site 324057012646 conserved gate region; other site 324057012647 putative PBP binding loops; other site 324057012648 ABC-ATPase subunit interface; other site 324057012649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012650 dimer interface [polypeptide binding]; other site 324057012651 conserved gate region; other site 324057012652 putative PBP binding loops; other site 324057012653 ABC-ATPase subunit interface; other site 324057012654 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057012655 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057012656 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 324057012657 Protein of unknown function; Region: DUF3658; pfam12395 324057012658 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057012659 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057012660 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012661 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012662 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 324057012663 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057012664 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324057012665 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 324057012666 Walker A/P-loop; other site 324057012667 ATP binding site [chemical binding]; other site 324057012668 Q-loop/lid; other site 324057012669 ABC transporter signature motif; other site 324057012670 Walker B; other site 324057012671 D-loop; other site 324057012672 H-loop/switch region; other site 324057012673 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057012674 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324057012675 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057012676 Walker A/P-loop; other site 324057012677 ATP binding site [chemical binding]; other site 324057012678 Q-loop/lid; other site 324057012679 ABC transporter signature motif; other site 324057012680 Walker B; other site 324057012681 D-loop; other site 324057012682 H-loop/switch region; other site 324057012683 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 324057012684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057012685 Walker A/P-loop; other site 324057012686 ATP binding site [chemical binding]; other site 324057012687 Q-loop/lid; other site 324057012688 ABC transporter signature motif; other site 324057012689 Walker B; other site 324057012690 D-loop; other site 324057012691 H-loop/switch region; other site 324057012692 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 324057012693 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 324057012694 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 324057012695 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 324057012696 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 324057012697 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324057012698 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 324057012699 Walker A/P-loop; other site 324057012700 ATP binding site [chemical binding]; other site 324057012701 Q-loop/lid; other site 324057012702 ABC transporter signature motif; other site 324057012703 Walker B; other site 324057012704 D-loop; other site 324057012705 H-loop/switch region; other site 324057012706 integral membrane protein; Region: integ_memb_HG; TIGR03954 324057012707 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 324057012708 EamA-like transporter family; Region: EamA; pfam00892 324057012709 EamA-like transporter family; Region: EamA; pfam00892 324057012710 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057012711 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057012712 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057012713 dimerization interface [polypeptide binding]; other site 324057012714 Cupin domain; Region: Cupin_2; pfam07883 324057012715 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057012716 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 324057012717 Metal-binding active site; metal-binding site 324057012718 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057012719 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057012720 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057012721 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324057012722 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057012723 non-specific DNA binding site [nucleotide binding]; other site 324057012724 salt bridge; other site 324057012725 sequence-specific DNA binding site [nucleotide binding]; other site 324057012726 Cupin domain; Region: Cupin_2; pfam07883 324057012727 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 324057012728 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 324057012729 DNA binding residues [nucleotide binding] 324057012730 putative dimer interface [polypeptide binding]; other site 324057012731 oxidoreductase; Provisional; Region: PRK06196 324057012732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057012733 NAD(P) binding site [chemical binding]; other site 324057012734 active site 324057012735 DinB family; Region: DinB; cl17821 324057012736 DinB superfamily; Region: DinB_2; pfam12867 324057012737 Uncharacterized conserved protein [Function unknown]; Region: COG1359 324057012738 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 324057012739 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 324057012740 potential catalytic triad [active] 324057012741 conserved cys residue [active] 324057012742 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 324057012743 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 324057012744 ligand binding site [chemical binding]; other site 324057012745 dimerization interface [polypeptide binding]; other site 324057012746 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 324057012747 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 324057012748 TM-ABC transporter signature motif; other site 324057012749 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 324057012750 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 324057012751 Walker A/P-loop; other site 324057012752 ATP binding site [chemical binding]; other site 324057012753 Q-loop/lid; other site 324057012754 ABC transporter signature motif; other site 324057012755 Walker B; other site 324057012756 D-loop; other site 324057012757 H-loop/switch region; other site 324057012758 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 324057012759 D-ribose pyranase; Provisional; Region: PRK11797 324057012760 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 324057012761 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 324057012762 substrate binding site [chemical binding]; other site 324057012763 dimer interface [polypeptide binding]; other site 324057012764 ATP binding site [chemical binding]; other site 324057012765 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057012766 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057012767 DNA binding site [nucleotide binding] 324057012768 domain linker motif; other site 324057012769 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 324057012770 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057012771 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057012772 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057012773 dimerization interface [polypeptide binding]; other site 324057012774 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 324057012775 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 324057012776 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 324057012777 active site 324057012778 dimer interface [polypeptide binding]; other site 324057012779 effector binding site; other site 324057012780 TSCPD domain; Region: TSCPD; pfam12637 324057012781 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 324057012782 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057012783 ATP binding site [chemical binding]; other site 324057012784 putative Mg++ binding site [ion binding]; other site 324057012785 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 324057012786 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057012787 nucleotide binding region [chemical binding]; other site 324057012788 ATP-binding site [chemical binding]; other site 324057012789 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 324057012790 YqzE-like protein; Region: YqzE; pfam14038 324057012791 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 324057012792 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 324057012793 active site 324057012794 metal binding site [ion binding]; metal-binding site 324057012795 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 324057012796 NodB motif; other site 324057012797 putative active site [active] 324057012798 putative catalytic site [active] 324057012799 Zn binding site [ion binding]; other site 324057012800 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057012801 active site 324057012802 Uncharacterized membrane protein [Function unknown]; Region: COG3949 324057012803 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 324057012804 AAA domain; Region: AAA_23; pfam13476 324057012805 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 324057012806 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057012807 active site 324057012808 metal binding site [ion binding]; metal-binding site 324057012809 DNA binding site [nucleotide binding] 324057012810 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057012811 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057012812 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 324057012813 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057012814 metal binding site [ion binding]; metal-binding site 324057012815 active site 324057012816 I-site; other site 324057012817 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 324057012818 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057012819 motif II; other site 324057012820 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 324057012821 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057012822 motif II; other site 324057012823 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 324057012824 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 324057012825 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 324057012826 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 324057012827 dimer interface [polypeptide binding]; other site 324057012828 putative radical transfer pathway; other site 324057012829 diiron center [ion binding]; other site 324057012830 tyrosyl radical; other site 324057012831 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 324057012832 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 324057012833 Class I ribonucleotide reductase; Region: RNR_I; cd01679 324057012834 active site 324057012835 dimer interface [polypeptide binding]; other site 324057012836 catalytic residues [active] 324057012837 effector binding site; other site 324057012838 R2 peptide binding site; other site 324057012839 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 324057012840 thymidine kinase; Provisional; Region: PRK04296 324057012841 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324057012842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057012843 S-adenosylmethionine binding site [chemical binding]; other site 324057012844 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 324057012845 S1 domain; Region: S1_2; pfam13509 324057012846 S1 domain; Region: S1_2; pfam13509 324057012847 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 324057012848 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057012849 Zn2+ binding site [ion binding]; other site 324057012850 Mg2+ binding site [ion binding]; other site 324057012851 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 324057012852 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 324057012853 active site 324057012854 (T/H)XGH motif; other site 324057012855 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 324057012856 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 324057012857 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 324057012858 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 324057012859 shikimate binding site; other site 324057012860 NAD(P) binding site [chemical binding]; other site 324057012861 GTPase YqeH; Provisional; Region: PRK13796 324057012862 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 324057012863 GTP/Mg2+ binding site [chemical binding]; other site 324057012864 G4 box; other site 324057012865 G5 box; other site 324057012866 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 324057012867 G1 box; other site 324057012868 G1 box; other site 324057012869 GTP/Mg2+ binding site [chemical binding]; other site 324057012870 Switch I region; other site 324057012871 G2 box; other site 324057012872 G2 box; other site 324057012873 Switch I region; other site 324057012874 G3 box; other site 324057012875 G3 box; other site 324057012876 Switch II region; other site 324057012877 Switch II region; other site 324057012878 G5 box; other site 324057012879 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 324057012880 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057012881 active site 324057012882 motif I; other site 324057012883 motif II; other site 324057012884 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 324057012885 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 324057012886 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 324057012887 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 324057012888 Protein of unknown function DUF58; Region: DUF58; pfam01882 324057012889 MoxR-like ATPases [General function prediction only]; Region: COG0714 324057012890 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057012891 Walker A motif; other site 324057012892 ATP binding site [chemical binding]; other site 324057012893 Walker B motif; other site 324057012894 arginine finger; other site 324057012895 Predicted integral membrane protein [Function unknown]; Region: COG0392 324057012896 Uncharacterized conserved protein [Function unknown]; Region: COG2898 324057012897 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 324057012898 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 324057012899 stage V sporulation protein AD; Provisional; Region: PRK12404 324057012900 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 324057012901 SpoVA protein; Region: SpoVA; cl04298 324057012902 SpoVA protein; Region: SpoVA; cl04298 324057012903 stage V sporulation protein AD; Provisional; Region: PRK12404 324057012904 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 324057012905 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 324057012906 Predicted membrane protein [Function unknown]; Region: COG2323 324057012907 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 324057012908 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 324057012909 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 324057012910 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 324057012911 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 324057012912 Response regulator receiver domain; Region: Response_reg; pfam00072 324057012913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057012914 active site 324057012915 phosphorylation site [posttranslational modification] 324057012916 intermolecular recognition site; other site 324057012917 dimerization interface [polypeptide binding]; other site 324057012918 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012919 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057012920 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012921 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057012922 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057012923 dimerization interface [polypeptide binding]; other site 324057012924 Histidine kinase; Region: His_kinase; pfam06580 324057012925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057012926 ATP binding site [chemical binding]; other site 324057012927 Mg2+ binding site [ion binding]; other site 324057012928 G-X-G motif; other site 324057012929 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057012930 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057012931 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057012932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012933 dimer interface [polypeptide binding]; other site 324057012934 conserved gate region; other site 324057012935 putative PBP binding loops; other site 324057012936 ABC-ATPase subunit interface; other site 324057012937 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324057012938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012939 dimer interface [polypeptide binding]; other site 324057012940 conserved gate region; other site 324057012941 putative PBP binding loops; other site 324057012942 ABC-ATPase subunit interface; other site 324057012943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 324057012944 Putative cyclase; Region: Cyclase; cl00814 324057012945 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057012946 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 324057012948 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057012949 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057012950 Coenzyme A binding pocket [chemical binding]; other site 324057012951 hypothetical protein; Validated; Region: PRK06769 324057012952 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057012953 active site 324057012954 motif I; other site 324057012955 motif II; other site 324057012956 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 324057012957 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 324057012958 nucleoside/Zn binding site; other site 324057012959 dimer interface [polypeptide binding]; other site 324057012960 catalytic motif [active] 324057012961 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 324057012962 MgtC family; Region: MgtC; pfam02308 324057012963 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057012964 putative metal binding site [ion binding]; other site 324057012965 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057012966 putative metal binding site [ion binding]; other site 324057012967 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 324057012968 Right handed beta helix region; Region: Beta_helix; pfam13229 324057012969 S-layer homology domain; Region: SLH; pfam00395 324057012970 S-layer homology domain; Region: SLH; pfam00395 324057012971 S-layer homology domain; Region: SLH; pfam00395 324057012972 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057012973 Helix-turn-helix domain; Region: HTH_31; pfam13560 324057012974 Response regulator receiver domain; Region: Response_reg; pfam00072 324057012975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057012976 active site 324057012977 phosphorylation site [posttranslational modification] 324057012978 intermolecular recognition site; other site 324057012979 dimerization interface [polypeptide binding]; other site 324057012980 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012981 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057012982 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057012983 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057012984 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057012985 dimerization interface [polypeptide binding]; other site 324057012986 Histidine kinase; Region: His_kinase; pfam06580 324057012987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057012988 ATP binding site [chemical binding]; other site 324057012989 Mg2+ binding site [ion binding]; other site 324057012990 G-X-G motif; other site 324057012991 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057012992 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057012993 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 324057012994 active site 324057012995 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057012996 putative metal binding site [ion binding]; other site 324057012997 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057012998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057012999 dimer interface [polypeptide binding]; other site 324057013000 conserved gate region; other site 324057013001 putative PBP binding loops; other site 324057013002 ABC-ATPase subunit interface; other site 324057013003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013004 dimer interface [polypeptide binding]; other site 324057013005 conserved gate region; other site 324057013006 putative PBP binding loops; other site 324057013007 ABC-ATPase subunit interface; other site 324057013008 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057013009 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 324057013010 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324057013011 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057013012 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 324057013013 Predicted transcriptional regulator [Transcription]; Region: COG4189 324057013014 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057013015 dimerization interface [polypeptide binding]; other site 324057013016 putative DNA binding site [nucleotide binding]; other site 324057013017 putative Zn2+ binding site [ion binding]; other site 324057013018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 324057013019 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 324057013020 active site 324057013021 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 324057013022 putative metal binding site [ion binding]; other site 324057013023 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 324057013024 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 324057013025 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057013026 DNA-binding site [nucleotide binding]; DNA binding site 324057013027 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057013028 dimerization interface [polypeptide binding]; other site 324057013029 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 324057013030 ligand binding site [chemical binding]; other site 324057013031 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 324057013032 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 324057013033 active site 324057013034 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 324057013035 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 324057013036 PKC phosphorylation site [posttranslational modification]; other site 324057013037 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057013038 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057013039 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057013040 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057013041 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057013042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013043 ABC-ATPase subunit interface; other site 324057013044 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057013045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013046 dimer interface [polypeptide binding]; other site 324057013047 conserved gate region; other site 324057013048 ABC-ATPase subunit interface; other site 324057013049 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057013050 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057013051 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057013052 Response regulator receiver domain; Region: Response_reg; pfam00072 324057013053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057013054 active site 324057013055 phosphorylation site [posttranslational modification] 324057013056 intermolecular recognition site; other site 324057013057 dimerization interface [polypeptide binding]; other site 324057013058 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013059 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013060 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057013061 dimerization interface [polypeptide binding]; other site 324057013062 Histidine kinase; Region: His_kinase; pfam06580 324057013063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057013064 ATP binding site [chemical binding]; other site 324057013065 Mg2+ binding site [ion binding]; other site 324057013066 G-X-G motif; other site 324057013067 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 324057013068 MFS/sugar transport protein; Region: MFS_2; pfam13347 324057013069 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324057013070 beta-D-glucuronidase; Provisional; Region: PRK10150 324057013071 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057013072 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 324057013073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013074 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013075 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013076 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057013077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057013078 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057013079 dimerization interface [polypeptide binding]; other site 324057013080 putative uracil/xanthine transporter; Provisional; Region: PRK11412 324057013081 IDEAL domain; Region: IDEAL; cl07452 324057013082 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 324057013083 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 324057013084 PYR/PP interface [polypeptide binding]; other site 324057013085 dimer interface [polypeptide binding]; other site 324057013086 TPP binding site [chemical binding]; other site 324057013087 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 324057013088 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 324057013089 TPP-binding site [chemical binding]; other site 324057013090 dimer interface [polypeptide binding]; other site 324057013091 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 324057013092 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 324057013093 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057013094 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057013095 Proline dehydrogenase; Region: Pro_dh; cl03282 324057013096 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057013097 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057013098 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013099 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057013100 Interdomain contacts; other site 324057013101 Cytokine receptor motif; other site 324057013102 Fibronectin type 3 domain; Region: FN3; smart00060 324057013103 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 324057013104 active site 324057013105 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 324057013106 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 324057013107 S-layer homology domain; Region: SLH; pfam00395 324057013108 S-layer homology domain; Region: SLH; pfam00395 324057013109 S-layer homology domain; Region: SLH; pfam00395 324057013110 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 324057013111 active site 324057013112 catalytic triad [active] 324057013113 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 324057013114 Family description; Region: VCBS; pfam13517 324057013115 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 324057013116 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 324057013117 putative active site [active] 324057013118 putative metal binding site [ion binding]; other site 324057013119 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 324057013120 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013121 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013122 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057013123 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057013124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013125 dimer interface [polypeptide binding]; other site 324057013126 conserved gate region; other site 324057013127 putative PBP binding loops; other site 324057013128 ABC-ATPase subunit interface; other site 324057013129 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057013130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013131 dimer interface [polypeptide binding]; other site 324057013132 conserved gate region; other site 324057013133 ABC-ATPase subunit interface; other site 324057013134 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 324057013135 alpha-galactosidase; Region: PLN02808; cl17638 324057013136 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 324057013137 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 324057013138 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 324057013139 S-layer homology domain; Region: SLH; pfam00395 324057013140 S-layer homology domain; Region: SLH; pfam00395 324057013141 S-layer homology domain; Region: SLH; pfam00395 324057013142 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 324057013143 substrate binding site [chemical binding]; other site 324057013144 active site 324057013145 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 324057013146 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057013147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013148 dimer interface [polypeptide binding]; other site 324057013149 conserved gate region; other site 324057013150 ABC-ATPase subunit interface; other site 324057013151 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057013152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013153 dimer interface [polypeptide binding]; other site 324057013154 conserved gate region; other site 324057013155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057013156 ABC-ATPase subunit interface; other site 324057013157 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057013158 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057013159 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057013160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013161 Spore germination protein; Region: Spore_permease; cl17796 324057013162 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057013163 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057013164 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057013165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057013166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057013167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057013168 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057013169 putative substrate translocation pore; other site 324057013170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057013171 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 324057013172 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 324057013173 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057013174 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057013175 DNA binding site [nucleotide binding] 324057013176 domain linker motif; other site 324057013177 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057013178 dimerization interface [polypeptide binding]; other site 324057013179 ligand binding site [chemical binding]; other site 324057013180 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 324057013181 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 324057013182 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 324057013183 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057013184 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057013185 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057013186 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 324057013187 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 324057013188 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 324057013189 VanZ like family; Region: VanZ; pfam04892 324057013190 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057013191 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057013192 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057013193 HAMP domain; Region: HAMP; pfam00672 324057013194 dimerization interface [polypeptide binding]; other site 324057013195 Histidine kinase; Region: His_kinase; pfam06580 324057013196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057013197 ATP binding site [chemical binding]; other site 324057013198 Mg2+ binding site [ion binding]; other site 324057013199 G-X-G motif; other site 324057013200 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057013201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057013202 active site 324057013203 phosphorylation site [posttranslational modification] 324057013204 intermolecular recognition site; other site 324057013205 dimerization interface [polypeptide binding]; other site 324057013206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013207 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 324057013208 active site 324057013209 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057013210 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057013211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013212 conserved gate region; other site 324057013213 putative PBP binding loops; other site 324057013214 ABC-ATPase subunit interface; other site 324057013215 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057013216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013217 dimer interface [polypeptide binding]; other site 324057013218 conserved gate region; other site 324057013219 putative PBP binding loops; other site 324057013220 ABC-ATPase subunit interface; other site 324057013221 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 324057013222 Glycosyl hydrolase family 49; Region: Glyco_hydro_49; pfam03718 324057013223 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 324057013224 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324057013225 active site 324057013226 HIGH motif; other site 324057013227 nucleotide binding site [chemical binding]; other site 324057013228 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324057013229 active site 324057013230 KMSKS motif; other site 324057013231 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 324057013232 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 324057013233 active site 324057013234 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 324057013235 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 324057013236 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 324057013237 dimer interface [polypeptide binding]; other site 324057013238 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057013239 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 324057013240 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 324057013241 active site residue [active] 324057013242 AAA domain; Region: AAA_17; pfam13207 324057013243 selenophosphate synthetase; Provisional; Region: PRK00943 324057013244 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 324057013245 dimerization interface [polypeptide binding]; other site 324057013246 putative ATP binding site [chemical binding]; other site 324057013247 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 324057013248 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 324057013249 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 324057013250 Sulfatase; Region: Sulfatase; cl17466 324057013251 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 324057013252 Sulfatase; Region: Sulfatase; pfam00884 324057013253 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324057013254 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 324057013255 Walker A/P-loop; other site 324057013256 ATP binding site [chemical binding]; other site 324057013257 Q-loop/lid; other site 324057013258 ABC transporter signature motif; other site 324057013259 Walker B; other site 324057013260 D-loop; other site 324057013261 H-loop/switch region; other site 324057013262 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324057013263 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 324057013264 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324057013265 Walker A/P-loop; other site 324057013266 ATP binding site [chemical binding]; other site 324057013267 Q-loop/lid; other site 324057013268 ABC transporter signature motif; other site 324057013269 Walker B; other site 324057013270 D-loop; other site 324057013271 H-loop/switch region; other site 324057013272 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324057013273 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 324057013274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013275 dimer interface [polypeptide binding]; other site 324057013276 conserved gate region; other site 324057013277 putative PBP binding loops; other site 324057013278 ABC-ATPase subunit interface; other site 324057013279 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 324057013280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013281 dimer interface [polypeptide binding]; other site 324057013282 conserved gate region; other site 324057013283 putative PBP binding loops; other site 324057013284 ABC-ATPase subunit interface; other site 324057013285 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 324057013286 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 324057013287 substrate binding site [chemical binding]; other site 324057013288 HAMP domain; Region: HAMP; pfam00672 324057013289 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013290 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013291 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 324057013292 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057013293 Interdomain contacts; other site 324057013294 Cytokine receptor motif; other site 324057013295 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 324057013296 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057013297 Interdomain contacts; other site 324057013298 Cytokine receptor motif; other site 324057013299 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057013300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057013301 NAD(P) binding site [chemical binding]; other site 324057013302 active site 324057013303 Methyltransferase domain; Region: Methyltransf_23; pfam13489 324057013304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057013305 S-adenosylmethionine binding site [chemical binding]; other site 324057013306 BNR repeat-like domain; Region: BNR_2; pfam13088 324057013307 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057013308 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057013309 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057013310 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057013311 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057013312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057013313 NAD(P) binding site [chemical binding]; other site 324057013314 active site 324057013315 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 324057013316 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 324057013317 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 324057013318 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 324057013319 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057013320 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057013321 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 324057013322 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 324057013323 DNA binding residues [nucleotide binding] 324057013324 putative dimer interface [polypeptide binding]; other site 324057013325 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 324057013326 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 324057013327 putative NAD(P) binding site [chemical binding]; other site 324057013328 putative substrate binding site [chemical binding]; other site 324057013329 catalytic Zn binding site [ion binding]; other site 324057013330 structural Zn binding site [ion binding]; other site 324057013331 dimer interface [polypeptide binding]; other site 324057013332 Beta-lactamase; Region: Beta-lactamase; pfam00144 324057013333 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 324057013334 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 324057013335 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 324057013336 Cupin domain; Region: Cupin_2; cl17218 324057013337 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057013338 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013339 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057013340 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057013341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013342 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324057013343 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057013344 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 324057013345 Alginate lyase; Region: Alginate_lyase; pfam05426 324057013346 Right handed beta helix region; Region: Beta_helix; pfam13229 324057013347 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 324057013348 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 324057013349 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 324057013350 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 324057013351 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 324057013352 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 324057013353 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057013354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013355 ABC-ATPase subunit interface; other site 324057013356 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057013357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013358 dimer interface [polypeptide binding]; other site 324057013359 conserved gate region; other site 324057013360 ABC-ATPase subunit interface; other site 324057013361 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057013362 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013363 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013364 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013365 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 324057013366 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 324057013367 putative active cleft [active] 324057013368 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057013369 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057013370 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013371 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013372 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057013373 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057013374 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013375 LysE type translocator; Region: LysE; cl00565 324057013376 Nicotianamine synthase protein; Region: NAS; cl17658 324057013377 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 324057013378 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057013379 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057013380 sugar binding site [chemical binding]; other site 324057013381 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057013382 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 324057013383 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057013384 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057013385 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057013386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057013387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013388 dimer interface [polypeptide binding]; other site 324057013389 conserved gate region; other site 324057013390 putative PBP binding loops; other site 324057013391 ABC-ATPase subunit interface; other site 324057013392 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057013393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057013394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013395 dimer interface [polypeptide binding]; other site 324057013396 putative PBP binding loops; other site 324057013397 ABC-ATPase subunit interface; other site 324057013398 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057013399 Helix-turn-helix domain; Region: HTH_18; pfam12833 324057013400 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013401 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 324057013402 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 324057013403 active site 324057013404 catalytic triad [active] 324057013405 oxyanion hole [active] 324057013406 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 324057013407 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 324057013408 active site 324057013409 catalytic site [active] 324057013410 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 324057013411 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 324057013412 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 324057013413 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 324057013414 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 324057013415 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 324057013416 putative substrate binding site [chemical binding]; other site 324057013417 active site 324057013418 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057013419 DNA-binding site [nucleotide binding]; DNA binding site 324057013420 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057013421 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057013422 dimerization interface [polypeptide binding]; other site 324057013423 ligand binding site [chemical binding]; other site 324057013424 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057013425 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057013426 Spore germination protein; Region: Spore_permease; pfam03845 324057013427 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057013428 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 324057013429 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 324057013430 intersubunit interface [polypeptide binding]; other site 324057013431 active site 324057013432 Zn2+ binding site [ion binding]; other site 324057013433 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057013434 DNA-binding site [nucleotide binding]; DNA binding site 324057013435 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 324057013436 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 324057013437 putative dimerization interface [polypeptide binding]; other site 324057013438 putative ligand binding site [chemical binding]; other site 324057013439 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 324057013440 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 324057013441 putative N- and C-terminal domain interface [polypeptide binding]; other site 324057013442 putative active site [active] 324057013443 MgATP binding site [chemical binding]; other site 324057013444 catalytic site [active] 324057013445 metal binding site [ion binding]; metal-binding site 324057013446 putative carbohydrate binding site [chemical binding]; other site 324057013447 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 324057013448 Predicted membrane protein [Function unknown]; Region: COG2323 324057013449 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057013450 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057013451 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057013452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013453 dimer interface [polypeptide binding]; other site 324057013454 conserved gate region; other site 324057013455 putative PBP binding loops; other site 324057013456 ABC-ATPase subunit interface; other site 324057013457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013458 dimer interface [polypeptide binding]; other site 324057013459 conserved gate region; other site 324057013460 putative PBP binding loops; other site 324057013461 ABC-ATPase subunit interface; other site 324057013462 D-mannonate dehydratase (UxuA); Region: UxuA; pfam03786 324057013463 mannonate dehydratase; Region: uxuA; TIGR00695 324057013464 mannonate dehydratase; Region: uxuA; TIGR00695 324057013465 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013466 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013467 Predicted transcriptional regulators [Transcription]; Region: COG1725 324057013468 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057013469 DNA-binding site [nucleotide binding]; DNA binding site 324057013470 FCD domain; Region: FCD; pfam07729 324057013471 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057013472 classical (c) SDRs; Region: SDR_c; cd05233 324057013473 NAD(P) binding site [chemical binding]; other site 324057013474 active site 324057013475 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 324057013476 classical (c) SDRs; Region: SDR_c; cd05233 324057013477 NAD(P) binding site [chemical binding]; other site 324057013478 active site 324057013479 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 324057013480 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 324057013481 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 324057013482 metal binding site [ion binding]; metal-binding site 324057013483 substrate binding pocket [chemical binding]; other site 324057013484 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 324057013485 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057013486 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057013487 active site 324057013488 catalytic tetrad [active] 324057013489 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057013490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013491 dimer interface [polypeptide binding]; other site 324057013492 conserved gate region; other site 324057013493 putative PBP binding loops; other site 324057013494 ABC-ATPase subunit interface; other site 324057013495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013496 dimer interface [polypeptide binding]; other site 324057013497 conserved gate region; other site 324057013498 ABC-ATPase subunit interface; other site 324057013499 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057013500 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057013501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057013502 active site 324057013503 phosphorylation site [posttranslational modification] 324057013504 intermolecular recognition site; other site 324057013505 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057013506 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013508 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057013509 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057013510 dimerization interface [polypeptide binding]; other site 324057013511 Histidine kinase; Region: His_kinase; pfam06580 324057013512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057013513 ATP binding site [chemical binding]; other site 324057013514 Mg2+ binding site [ion binding]; other site 324057013515 G-X-G motif; other site 324057013516 Predicted permeases [General function prediction only]; Region: RarD; COG2962 324057013517 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057013518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057013519 active site 324057013520 phosphorylation site [posttranslational modification] 324057013521 intermolecular recognition site; other site 324057013522 dimerization interface [polypeptide binding]; other site 324057013523 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057013524 DNA binding residues [nucleotide binding] 324057013525 dimerization interface [polypeptide binding]; other site 324057013526 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324057013527 Histidine kinase; Region: HisKA_3; pfam07730 324057013528 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 324057013529 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324057013530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057013531 Walker A/P-loop; other site 324057013532 ATP binding site [chemical binding]; other site 324057013533 Q-loop/lid; other site 324057013534 ABC transporter signature motif; other site 324057013535 Walker B; other site 324057013536 D-loop; other site 324057013537 H-loop/switch region; other site 324057013538 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 324057013539 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 324057013540 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 324057013541 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 324057013542 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 324057013543 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 324057013544 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324057013545 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324057013546 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057013547 MarR family; Region: MarR_2; pfam12802 324057013548 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 324057013549 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 324057013550 CysD dimerization site [polypeptide binding]; other site 324057013551 G1 box; other site 324057013552 putative GEF interaction site [polypeptide binding]; other site 324057013553 GTP/Mg2+ binding site [chemical binding]; other site 324057013554 Switch I region; other site 324057013555 G2 box; other site 324057013556 G3 box; other site 324057013557 Switch II region; other site 324057013558 G4 box; other site 324057013559 G5 box; other site 324057013560 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 324057013561 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 324057013562 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 324057013563 active site 324057013564 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 324057013565 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 324057013566 Active Sites [active] 324057013567 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057013568 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 324057013569 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 324057013570 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 324057013571 active site 324057013572 catalytic triad [active] 324057013573 oxyanion hole [active] 324057013574 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 324057013575 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057013576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013577 dimer interface [polypeptide binding]; other site 324057013578 conserved gate region; other site 324057013579 ABC-ATPase subunit interface; other site 324057013580 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057013581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013582 ABC-ATPase subunit interface; other site 324057013583 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 324057013584 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057013585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013586 dimer interface [polypeptide binding]; other site 324057013587 conserved gate region; other site 324057013588 ABC-ATPase subunit interface; other site 324057013589 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057013590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013591 dimer interface [polypeptide binding]; other site 324057013592 conserved gate region; other site 324057013593 putative PBP binding loops; other site 324057013594 ABC-ATPase subunit interface; other site 324057013595 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 324057013596 putative metal binding site [ion binding]; other site 324057013597 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 324057013598 putative metal binding site [ion binding]; other site 324057013599 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057013600 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 324057013601 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057013602 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057013603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057013604 Response regulator receiver domain; Region: Response_reg; pfam00072 324057013605 active site 324057013606 phosphorylation site [posttranslational modification] 324057013607 intermolecular recognition site; other site 324057013608 dimerization interface [polypeptide binding]; other site 324057013609 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013611 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057013612 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 324057013613 Domain of unknown function (DUF1083); Region: DUF1083; pfam06452 324057013614 putative ligand binding site [chemical binding]; other site 324057013615 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 324057013616 Ca binding site [ion binding]; other site 324057013617 carbohydrate binding site [chemical binding]; other site 324057013618 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057013619 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 324057013620 Walker A/P-loop; other site 324057013621 ATP binding site [chemical binding]; other site 324057013622 Q-loop/lid; other site 324057013623 ABC transporter signature motif; other site 324057013624 Walker B; other site 324057013625 D-loop; other site 324057013626 H-loop/switch region; other site 324057013627 FtsX-like permease family; Region: FtsX; pfam02687 324057013628 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 324057013629 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 324057013630 FtsX-like permease family; Region: FtsX; pfam02687 324057013631 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 324057013632 HlyD family secretion protein; Region: HlyD_3; pfam13437 324057013633 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057013634 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 324057013635 Walker A/P-loop; other site 324057013636 ATP binding site [chemical binding]; other site 324057013637 Q-loop/lid; other site 324057013638 ABC transporter signature motif; other site 324057013639 Walker B; other site 324057013640 D-loop; other site 324057013641 H-loop/switch region; other site 324057013642 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 324057013643 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 324057013644 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 324057013645 active site 324057013646 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 324057013647 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057013648 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324057013649 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 324057013650 Walker A/P-loop; other site 324057013651 ATP binding site [chemical binding]; other site 324057013652 Q-loop/lid; other site 324057013653 ABC transporter signature motif; other site 324057013654 Walker B; other site 324057013655 D-loop; other site 324057013656 H-loop/switch region; other site 324057013657 alpha-galactosidase; Region: PLN02808; cl17638 324057013658 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057013659 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013660 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013661 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 324057013662 substrate binding site [chemical binding]; other site 324057013663 active site 324057013664 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057013665 metal binding site [ion binding]; metal-binding site 324057013666 ligand binding site [chemical binding]; other site 324057013667 Response regulator receiver domain; Region: Response_reg; pfam00072 324057013668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057013669 active site 324057013670 phosphorylation site [posttranslational modification] 324057013671 intermolecular recognition site; other site 324057013672 dimerization interface [polypeptide binding]; other site 324057013673 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013674 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013675 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057013676 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057013677 dimerization interface [polypeptide binding]; other site 324057013678 Histidine kinase; Region: His_kinase; pfam06580 324057013679 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 324057013680 ATP binding site [chemical binding]; other site 324057013681 Mg2+ binding site [ion binding]; other site 324057013682 G-X-G motif; other site 324057013683 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057013684 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 324057013685 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 324057013686 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 324057013687 putative sugar binding sites [chemical binding]; other site 324057013688 Q-X-W motif; other site 324057013689 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013690 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013691 Carboxylesterase family; Region: COesterase; pfam00135 324057013692 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 324057013693 substrate binding pocket [chemical binding]; other site 324057013694 catalytic triad [active] 324057013695 Protein of unknown function, DUF608; Region: DUF608; pfam04685 324057013696 Response regulator receiver domain; Region: Response_reg; pfam00072 324057013697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057013698 active site 324057013699 phosphorylation site [posttranslational modification] 324057013700 intermolecular recognition site; other site 324057013701 dimerization interface [polypeptide binding]; other site 324057013702 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057013703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013704 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013705 HAMP domain; Region: HAMP; pfam00672 324057013706 dimerization interface [polypeptide binding]; other site 324057013707 Histidine kinase; Region: His_kinase; pfam06580 324057013708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057013709 ATP binding site [chemical binding]; other site 324057013710 Mg2+ binding site [ion binding]; other site 324057013711 G-X-G motif; other site 324057013712 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 324057013713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 324057013714 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057013715 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057013716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013717 dimer interface [polypeptide binding]; other site 324057013718 conserved gate region; other site 324057013719 putative PBP binding loops; other site 324057013720 ABC-ATPase subunit interface; other site 324057013721 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057013722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013723 ABC-ATPase subunit interface; other site 324057013724 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057013725 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013726 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013727 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 324057013728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 324057013729 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057013730 dockerin binding interface; other site 324057013731 S-layer homology domain; Region: SLH; pfam00395 324057013732 S-layer homology domain; Region: SLH; pfam00395 324057013733 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 324057013734 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057013735 dockerin binding interface; other site 324057013736 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057013737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013738 dimer interface [polypeptide binding]; other site 324057013739 conserved gate region; other site 324057013740 ABC-ATPase subunit interface; other site 324057013741 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057013742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013743 dimer interface [polypeptide binding]; other site 324057013744 conserved gate region; other site 324057013745 putative PBP binding loops; other site 324057013746 ABC-ATPase subunit interface; other site 324057013747 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057013748 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057013749 Response regulator receiver domain; Region: Response_reg; pfam00072 324057013750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057013751 active site 324057013752 phosphorylation site [posttranslational modification] 324057013753 intermolecular recognition site; other site 324057013754 dimerization interface [polypeptide binding]; other site 324057013755 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057013756 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013757 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057013758 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057013759 dimerization interface [polypeptide binding]; other site 324057013760 Histidine kinase; Region: His_kinase; pfam06580 324057013761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057013762 ATP binding site [chemical binding]; other site 324057013763 Mg2+ binding site [ion binding]; other site 324057013764 G-X-G motif; other site 324057013765 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 324057013766 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06077 324057013767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057013768 NAD(P) binding site [chemical binding]; other site 324057013769 active site 324057013770 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 324057013771 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 324057013772 Cupin domain; Region: Cupin_2; pfam07883 324057013773 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013774 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013775 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 324057013776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057013777 NAD(P) binding site [chemical binding]; other site 324057013778 active site 324057013779 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057013780 sporulation sigma factor SigK; Reviewed; Region: PRK05803 324057013781 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057013782 DNA binding residues [nucleotide binding] 324057013783 TIGR02679 family protein; Region: TIGR02679 324057013784 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 324057013785 TIGR02680 family protein; Region: TIGR02680 324057013786 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 324057013787 Protein of unknown function (DUF2398); Region: DUF2398; pfam09661 324057013788 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 324057013789 TIGR02677 family protein; Region: TIGR02677 324057013790 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 324057013791 DNA binding residues [nucleotide binding] 324057013792 Part of AAA domain; Region: AAA_19; pfam13245 324057013793 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 324057013794 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 324057013795 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057013796 Walker A/P-loop; other site 324057013797 ATP binding site [chemical binding]; other site 324057013798 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 324057013799 putative active site [active] 324057013800 putative metal-binding site [ion binding]; other site 324057013801 sporulation sigma factor SigK; Reviewed; Region: PRK05803 324057013802 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057013803 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057013804 DNA binding residues [nucleotide binding] 324057013805 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057013806 manganese transport protein MntH; Reviewed; Region: PRK00701 324057013807 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 324057013808 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 324057013809 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 324057013810 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 324057013811 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 324057013812 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 324057013813 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057013814 FeS/SAM binding site; other site 324057013815 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 324057013816 active site 324057013817 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 324057013818 Ligand Binding Site [chemical binding]; other site 324057013819 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 324057013820 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 324057013821 Moco binding site; other site 324057013822 metal coordination site [ion binding]; other site 324057013823 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 324057013824 Type I cohesin domain, interaction partner of dockerin; Region: Type_I_cohesin_like; cd08548 324057013825 dockerin binding interface; other site 324057013826 S-layer homology domain; Region: SLH; pfam00395 324057013827 S-layer homology domain; Region: SLH; pfam00395 324057013828 S-layer homology domain; Region: SLH; pfam00395 324057013829 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057013830 MarR family; Region: MarR; pfam01047 324057013831 MarR family; Region: MarR_2; cl17246 324057013832 UreD urease accessory protein; Region: UreD; cl00530 324057013833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057013834 Walker A motif; other site 324057013835 ATP binding site [chemical binding]; other site 324057013836 arginine finger; other site 324057013837 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 324057013838 UreF; Region: UreF; pfam01730 324057013839 urease subunit alpha; Reviewed; Region: ureC; PRK13207 324057013840 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 324057013841 subunit interactions [polypeptide binding]; other site 324057013842 active site 324057013843 flap region; other site 324057013844 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 324057013845 gamma-beta subunit interface [polypeptide binding]; other site 324057013846 alpha-beta subunit interface [polypeptide binding]; other site 324057013847 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 324057013848 alpha-gamma subunit interface [polypeptide binding]; other site 324057013849 beta-gamma subunit interface [polypeptide binding]; other site 324057013850 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 324057013851 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 324057013852 TM-ABC transporter signature motif; other site 324057013853 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 324057013854 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057013855 Walker A/P-loop; other site 324057013856 ATP binding site [chemical binding]; other site 324057013857 Q-loop/lid; other site 324057013858 ABC transporter signature motif; other site 324057013859 Walker B; other site 324057013860 D-loop; other site 324057013861 H-loop/switch region; other site 324057013862 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 324057013863 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 324057013864 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057013865 ligand binding site [chemical binding]; other site 324057013866 calcium binding site [ion binding]; other site 324057013867 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 324057013868 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057013869 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057013870 Cache domain; Region: Cache_1; pfam02743 324057013871 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057013872 dimerization interface [polypeptide binding]; other site 324057013873 Histidine kinase; Region: His_kinase; pfam06580 324057013874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057013875 ATP binding site [chemical binding]; other site 324057013876 Mg2+ binding site [ion binding]; other site 324057013877 G-X-G motif; other site 324057013878 Response regulator receiver domain; Region: Response_reg; pfam00072 324057013879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057013880 active site 324057013881 phosphorylation site [posttranslational modification] 324057013882 intermolecular recognition site; other site 324057013883 dimerization interface [polypeptide binding]; other site 324057013884 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057013885 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057013886 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 324057013887 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 324057013888 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 324057013889 NodB motif; other site 324057013890 putative active site [active] 324057013891 putative catalytic site [active] 324057013892 putative Zn binding site [ion binding]; other site 324057013893 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 324057013894 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 324057013895 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 324057013896 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 324057013897 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057013898 dimerization interface [polypeptide binding]; other site 324057013899 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057013900 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057013901 dimer interface [polypeptide binding]; other site 324057013902 putative CheW interface [polypeptide binding]; other site 324057013903 YceG-like family; Region: YceG; pfam02618 324057013904 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 324057013905 dimerization interface [polypeptide binding]; other site 324057013906 hypothetical protein; Provisional; Region: PRK13678 324057013907 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 324057013908 hypothetical protein; Provisional; Region: PRK05473 324057013909 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 324057013910 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 324057013911 motif 1; other site 324057013912 active site 324057013913 motif 2; other site 324057013914 motif 3; other site 324057013915 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 324057013916 DHHA1 domain; Region: DHHA1; pfam02272 324057013917 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324057013918 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 324057013919 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 324057013920 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 324057013921 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057013922 catalytic residue [active] 324057013923 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 324057013924 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057013925 active site 324057013926 motif I; other site 324057013927 motif II; other site 324057013928 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 324057013929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013930 dimer interface [polypeptide binding]; other site 324057013931 conserved gate region; other site 324057013932 putative PBP binding loops; other site 324057013933 ABC-ATPase subunit interface; other site 324057013934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057013935 dimer interface [polypeptide binding]; other site 324057013936 conserved gate region; other site 324057013937 putative PBP binding loops; other site 324057013938 ABC-ATPase subunit interface; other site 324057013939 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 324057013940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057013941 Walker A/P-loop; other site 324057013942 ATP binding site [chemical binding]; other site 324057013943 Q-loop/lid; other site 324057013944 ABC transporter signature motif; other site 324057013945 Walker B; other site 324057013946 D-loop; other site 324057013947 H-loop/switch region; other site 324057013948 TOBE domain; Region: TOBE_2; pfam08402 324057013949 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 324057013950 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 324057013951 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 324057013952 PRC-barrel domain; Region: PRC; pfam05239 324057013953 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 324057013954 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 324057013955 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057013956 catalytic residue [active] 324057013957 Predicted transcriptional regulator [Transcription]; Region: COG1959 324057013958 Transcriptional regulator; Region: Rrf2; pfam02082 324057013959 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 324057013960 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 324057013961 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 324057013962 Domain of unknown function DUF21; Region: DUF21; pfam01595 324057013963 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 324057013964 Transporter associated domain; Region: CorC_HlyC; smart01091 324057013965 CopC domain; Region: CopC; pfam04234 324057013966 Copper resistance protein D; Region: CopD; cl00563 324057013967 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 324057013968 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324057013969 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 324057013970 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 324057013971 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 324057013972 putative NAD(P) binding site [chemical binding]; other site 324057013973 catalytic Zn binding site [ion binding]; other site 324057013974 structural Zn binding site [ion binding]; other site 324057013975 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 324057013976 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 324057013977 siderophore binding site; other site 324057013978 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 324057013979 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057013980 ABC-ATPase subunit interface; other site 324057013981 dimer interface [polypeptide binding]; other site 324057013982 putative PBP binding regions; other site 324057013983 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 324057013984 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057013985 ABC-ATPase subunit interface; other site 324057013986 dimer interface [polypeptide binding]; other site 324057013987 putative PBP binding regions; other site 324057013988 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 324057013989 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 324057013990 Walker A/P-loop; other site 324057013991 ATP binding site [chemical binding]; other site 324057013992 Q-loop/lid; other site 324057013993 ABC transporter signature motif; other site 324057013994 Walker B; other site 324057013995 D-loop; other site 324057013996 H-loop/switch region; other site 324057013997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057013998 ATP binding site [chemical binding]; other site 324057013999 Mg2+ binding site [ion binding]; other site 324057014000 G-X-G motif; other site 324057014001 recombination factor protein RarA; Reviewed; Region: PRK13342 324057014002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057014003 Walker A motif; other site 324057014004 ATP binding site [chemical binding]; other site 324057014005 Walker B motif; other site 324057014006 arginine finger; other site 324057014007 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 324057014008 mannonate dehydratase; Region: uxuA; TIGR00695 324057014009 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057014010 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057014011 dimer interface [polypeptide binding]; other site 324057014012 putative CheW interface [polypeptide binding]; other site 324057014013 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057014014 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 324057014015 putative active site [active] 324057014016 heme pocket [chemical binding]; other site 324057014017 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 324057014018 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057014019 putative active site [active] 324057014020 heme pocket [chemical binding]; other site 324057014021 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057014022 putative active site [active] 324057014023 heme pocket [chemical binding]; other site 324057014024 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057014025 putative active site [active] 324057014026 heme pocket [chemical binding]; other site 324057014027 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057014028 metal binding site [ion binding]; metal-binding site 324057014029 active site 324057014030 I-site; other site 324057014031 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 324057014032 PilZ domain; Region: PilZ; pfam07238 324057014033 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 324057014034 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 324057014035 putative ATP binding site [chemical binding]; other site 324057014036 putative substrate interface [chemical binding]; other site 324057014037 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 324057014038 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 324057014039 dimer interface [polypeptide binding]; other site 324057014040 anticodon binding site; other site 324057014041 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 324057014042 homodimer interface [polypeptide binding]; other site 324057014043 motif 1; other site 324057014044 active site 324057014045 motif 2; other site 324057014046 GAD domain; Region: GAD; pfam02938 324057014047 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 324057014048 motif 3; other site 324057014049 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 324057014050 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 324057014051 dimer interface [polypeptide binding]; other site 324057014052 motif 1; other site 324057014053 active site 324057014054 motif 2; other site 324057014055 motif 3; other site 324057014056 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 324057014057 anticodon binding site; other site 324057014058 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 324057014059 putative active site [active] 324057014060 dimerization interface [polypeptide binding]; other site 324057014061 putative tRNAtyr binding site [nucleotide binding]; other site 324057014062 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 324057014063 HD domain; Region: HD_4; pfam13328 324057014064 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 324057014065 synthetase active site [active] 324057014066 NTP binding site [chemical binding]; other site 324057014067 metal binding site [ion binding]; metal-binding site 324057014068 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 324057014069 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 324057014070 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057014071 HAMP domain; Region: HAMP; pfam00672 324057014072 dimerization interface [polypeptide binding]; other site 324057014073 Histidine kinase; Region: His_kinase; pfam06580 324057014074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057014075 ATP binding site [chemical binding]; other site 324057014076 Mg2+ binding site [ion binding]; other site 324057014077 G-X-G motif; other site 324057014078 Response regulator receiver domain; Region: Response_reg; pfam00072 324057014079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057014080 active site 324057014081 phosphorylation site [posttranslational modification] 324057014082 intermolecular recognition site; other site 324057014083 dimerization interface [polypeptide binding]; other site 324057014084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057014085 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057014086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057014087 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057014088 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057014089 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057014090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014091 dimer interface [polypeptide binding]; other site 324057014092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057014093 ABC-ATPase subunit interface; other site 324057014094 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057014095 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 324057014096 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057014097 active site 324057014098 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 324057014099 DHH family; Region: DHH; pfam01368 324057014100 DHHA1 domain; Region: DHHA1; pfam02272 324057014101 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 324057014102 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 324057014103 Cation efflux family; Region: Cation_efflux; cl00316 324057014104 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 324057014105 Protein export membrane protein; Region: SecD_SecF; pfam02355 324057014106 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 324057014107 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 324057014108 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 324057014109 stage V sporulation protein B; Region: spore_V_B; TIGR02900 324057014110 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 324057014111 Predicted membrane protein [Function unknown]; Region: COG2323 324057014112 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 324057014113 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 324057014114 transmembrane helices; other site 324057014115 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 324057014116 Preprotein translocase subunit; Region: YajC; pfam02699 324057014117 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 324057014118 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 324057014119 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 324057014120 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 324057014121 Stage II sporulation protein; Region: SpoIID; pfam08486 324057014122 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 324057014123 Protein of unknown function, DUF393; Region: DUF393; pfam04134 324057014124 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 324057014125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057014126 Walker A motif; other site 324057014127 ATP binding site [chemical binding]; other site 324057014128 Walker B motif; other site 324057014129 arginine finger; other site 324057014130 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 324057014131 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 324057014132 RuvA N terminal domain; Region: RuvA_N; pfam01330 324057014133 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 324057014134 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 324057014135 active site 324057014136 putative DNA-binding cleft [nucleotide binding]; other site 324057014137 dimer interface [polypeptide binding]; other site 324057014138 BofC C-terminal domain; Region: BofC_C; pfam08955 324057014139 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057014140 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 324057014141 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057014142 prephenate dehydratase; Provisional; Region: PRK11898 324057014143 Prephenate dehydratase; Region: PDT; pfam00800 324057014144 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 324057014145 putative L-Phe binding site [chemical binding]; other site 324057014146 homoserine kinase; Provisional; Region: PRK01212 324057014147 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 324057014148 homoserine dehydrogenase; Provisional; Region: PRK06349 324057014149 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 324057014150 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 324057014151 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 324057014152 hypothetical protein; Provisional; Region: PRK04435 324057014153 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 324057014154 GTPase CgtA; Reviewed; Region: obgE; PRK12297 324057014155 GTP1/OBG; Region: GTP1_OBG; pfam01018 324057014156 Obg GTPase; Region: Obg; cd01898 324057014157 G1 box; other site 324057014158 GTP/Mg2+ binding site [chemical binding]; other site 324057014159 Switch I region; other site 324057014160 G2 box; other site 324057014161 G3 box; other site 324057014162 Switch II region; other site 324057014163 G4 box; other site 324057014164 G5 box; other site 324057014165 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 324057014166 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 324057014167 hypothetical protein; Provisional; Region: PRK14553 324057014168 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 324057014169 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 324057014170 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 324057014171 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 324057014172 homodimer interface [polypeptide binding]; other site 324057014173 oligonucleotide binding site [chemical binding]; other site 324057014174 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 324057014175 Peptidase family M50; Region: Peptidase_M50; pfam02163 324057014176 active site 324057014177 putative substrate binding region [chemical binding]; other site 324057014178 Peptidase family M23; Region: Peptidase_M23; pfam01551 324057014179 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 324057014180 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 324057014181 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 324057014182 Switch I; other site 324057014183 Switch II; other site 324057014184 septum formation inhibitor; Reviewed; Region: minC; PRK00513 324057014185 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 324057014186 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 324057014187 rod shape-determining protein MreC; Provisional; Region: PRK13922 324057014188 rod shape-determining protein MreC; Region: MreC; pfam04085 324057014189 rod shape-determining protein MreB; Provisional; Region: PRK13927 324057014190 MreB and similar proteins; Region: MreB_like; cd10225 324057014191 nucleotide binding site [chemical binding]; other site 324057014192 Mg binding site [ion binding]; other site 324057014193 putative protofilament interaction site [polypeptide binding]; other site 324057014194 RodZ interaction site [polypeptide binding]; other site 324057014195 hypothetical protein; Reviewed; Region: PRK00024 324057014196 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 324057014197 MPN+ (JAMM) motif; other site 324057014198 Zinc-binding site [ion binding]; other site 324057014199 Maf-like protein; Region: Maf; pfam02545 324057014200 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 324057014201 active site 324057014202 dimer interface [polypeptide binding]; other site 324057014203 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 324057014204 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 324057014205 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 324057014206 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324057014207 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324057014208 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 324057014209 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324057014210 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324057014211 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 324057014212 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324057014213 active site 324057014214 HIGH motif; other site 324057014215 nucleotide binding site [chemical binding]; other site 324057014216 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 324057014217 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 324057014218 active site 324057014219 KMSKS motif; other site 324057014220 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 324057014221 tRNA binding surface [nucleotide binding]; other site 324057014222 anticodon binding site; other site 324057014223 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 324057014224 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 324057014225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057014226 putative substrate translocation pore; other site 324057014227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057014228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057014229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057014230 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 324057014231 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 324057014232 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057014233 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 324057014234 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 324057014235 active site 324057014236 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 324057014237 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324057014238 inhibitor-cofactor binding pocket; inhibition site 324057014239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057014240 catalytic residue [active] 324057014241 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 324057014242 dimer interface [polypeptide binding]; other site 324057014243 active site 324057014244 Schiff base residues; other site 324057014245 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 324057014246 active site 324057014247 SAM binding site [chemical binding]; other site 324057014248 homodimer interface [polypeptide binding]; other site 324057014249 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 324057014250 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 324057014251 active site 324057014252 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 324057014253 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 324057014254 domain interfaces; other site 324057014255 active site 324057014256 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 324057014257 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 324057014258 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 324057014259 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 324057014260 tRNA; other site 324057014261 putative tRNA binding site [nucleotide binding]; other site 324057014262 putative NADP binding site [chemical binding]; other site 324057014263 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 324057014264 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 324057014265 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 324057014266 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 324057014267 G1 box; other site 324057014268 GTP/Mg2+ binding site [chemical binding]; other site 324057014269 Switch I region; other site 324057014270 G2 box; other site 324057014271 G3 box; other site 324057014272 Switch II region; other site 324057014273 G4 box; other site 324057014274 G5 box; other site 324057014275 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 324057014276 Found in ATP-dependent protease La (LON); Region: LON; smart00464 324057014277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057014278 Walker A motif; other site 324057014279 ATP binding site [chemical binding]; other site 324057014280 Walker B motif; other site 324057014281 arginine finger; other site 324057014282 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 324057014283 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 324057014284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057014285 Walker A motif; other site 324057014286 ATP binding site [chemical binding]; other site 324057014287 Walker B motif; other site 324057014288 arginine finger; other site 324057014289 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 324057014290 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 324057014291 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 324057014292 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 324057014293 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 324057014294 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 324057014295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057014296 Walker A motif; other site 324057014297 ATP binding site [chemical binding]; other site 324057014298 Walker B motif; other site 324057014299 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 324057014300 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 324057014301 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 324057014302 oligomer interface [polypeptide binding]; other site 324057014303 active site residues [active] 324057014304 trigger factor; Provisional; Region: tig; PRK01490 324057014305 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 324057014306 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 324057014307 Predicted transcriptional regulators [Transcription]; Region: COG1733 324057014308 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 324057014309 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 324057014310 dimer interface [polypeptide binding]; other site 324057014311 FMN binding site [chemical binding]; other site 324057014312 AAA domain; Region: AAA_33; pfam13671 324057014313 AAA domain; Region: AAA_17; pfam13207 324057014314 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 324057014315 active site 324057014316 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 324057014317 dimer interface [polypeptide binding]; other site 324057014318 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 324057014319 Ligand Binding Site [chemical binding]; other site 324057014320 Molecular Tunnel; other site 324057014321 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 324057014322 active site 324057014323 dimerization interface [polypeptide binding]; other site 324057014324 ribonuclease PH; Reviewed; Region: rph; PRK00173 324057014325 Ribonuclease PH; Region: RNase_PH_bact; cd11362 324057014326 hexamer interface [polypeptide binding]; other site 324057014327 active site 324057014328 Sporulation and spore germination; Region: Germane; pfam10646 324057014329 Sporulation and spore germination; Region: Germane; pfam10646 324057014330 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 324057014331 tetramer interfaces [polypeptide binding]; other site 324057014332 binuclear metal-binding site [ion binding]; other site 324057014333 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 324057014334 ligand-binding site [chemical binding]; other site 324057014335 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 324057014336 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 324057014337 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 324057014338 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 324057014339 homotetramer interface [polypeptide binding]; other site 324057014340 FMN binding site [chemical binding]; other site 324057014341 homodimer contacts [polypeptide binding]; other site 324057014342 putative active site [active] 324057014343 putative substrate binding site [chemical binding]; other site 324057014344 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 324057014345 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 324057014346 active site 324057014347 trimer interface [polypeptide binding]; other site 324057014348 allosteric site; other site 324057014349 active site lid [active] 324057014350 hexamer (dimer of trimers) interface [polypeptide binding]; other site 324057014351 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 324057014352 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 324057014353 active site 324057014354 dimer interface [polypeptide binding]; other site 324057014355 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324057014356 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 324057014357 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 324057014358 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 324057014359 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 324057014360 substrate binding site [chemical binding]; other site 324057014361 ATP binding site [chemical binding]; other site 324057014362 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 324057014363 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057014364 ATP binding site [chemical binding]; other site 324057014365 putative Mg++ binding site [ion binding]; other site 324057014366 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057014367 nucleotide binding region [chemical binding]; other site 324057014368 ATP-binding site [chemical binding]; other site 324057014369 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 324057014370 HRDC domain; Region: HRDC; pfam00570 324057014371 malate dehydrogenase; Reviewed; Region: PRK06223 324057014372 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 324057014373 NAD(P) binding site [chemical binding]; other site 324057014374 dimer interface [polypeptide binding]; other site 324057014375 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324057014376 substrate binding site [chemical binding]; other site 324057014377 isocitrate dehydrogenase; Validated; Region: PRK07362 324057014378 isocitrate dehydrogenase; Reviewed; Region: PRK07006 324057014379 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 324057014380 dimer interface [polypeptide binding]; other site 324057014381 Citrate synthase; Region: Citrate_synt; pfam00285 324057014382 active site 324057014383 citrylCoA binding site [chemical binding]; other site 324057014384 oxalacetate/citrate binding site [chemical binding]; other site 324057014385 coenzyme A binding site [chemical binding]; other site 324057014386 catalytic triad [active] 324057014387 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 324057014388 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 324057014389 polyphosphate kinase; Provisional; Region: PRK05443 324057014390 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 324057014391 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 324057014392 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 324057014393 putative domain interface [polypeptide binding]; other site 324057014394 putative active site [active] 324057014395 catalytic site [active] 324057014396 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 324057014397 putative domain interface [polypeptide binding]; other site 324057014398 putative active site [active] 324057014399 catalytic site [active] 324057014400 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 324057014401 active site 324057014402 pyruvate kinase; Provisional; Region: PRK06354 324057014403 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 324057014404 domain interfaces; other site 324057014405 active site 324057014406 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 324057014407 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 324057014408 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 324057014409 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 324057014410 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 324057014411 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 324057014412 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 324057014413 tetramer interfaces [polypeptide binding]; other site 324057014414 binuclear metal-binding site [ion binding]; other site 324057014415 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 324057014416 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 324057014417 active site 324057014418 PHP Thumb interface [polypeptide binding]; other site 324057014419 metal binding site [ion binding]; metal-binding site 324057014420 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 324057014421 generic binding surface I; other site 324057014422 generic binding surface II; other site 324057014423 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 324057014424 YtpI-like protein; Region: YtpI; pfam14007 324057014425 GTPase RsgA; Reviewed; Region: PRK01889 324057014426 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 324057014427 RNA binding site [nucleotide binding]; other site 324057014428 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 324057014429 GTPase/Zn-binding domain interface [polypeptide binding]; other site 324057014430 GTP/Mg2+ binding site [chemical binding]; other site 324057014431 G4 box; other site 324057014432 G5 box; other site 324057014433 G1 box; other site 324057014434 Switch I region; other site 324057014435 G2 box; other site 324057014436 G3 box; other site 324057014437 Switch II region; other site 324057014438 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 324057014439 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 324057014440 DNA-binding site [nucleotide binding]; DNA binding site 324057014441 DRTGG domain; Region: DRTGG; pfam07085 324057014442 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 324057014443 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324057014444 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057014445 non-specific DNA binding site [nucleotide binding]; other site 324057014446 salt bridge; other site 324057014447 sequence-specific DNA binding site [nucleotide binding]; other site 324057014448 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 324057014449 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 324057014450 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 324057014451 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 324057014452 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 324057014453 Coenzyme A binding pocket [chemical binding]; other site 324057014454 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057014455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057014456 active site 324057014457 phosphorylation site [posttranslational modification] 324057014458 intermolecular recognition site; other site 324057014459 dimerization interface [polypeptide binding]; other site 324057014460 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057014461 DNA binding site [nucleotide binding] 324057014462 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057014463 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057014464 dimerization interface [polypeptide binding]; other site 324057014465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057014466 dimer interface [polypeptide binding]; other site 324057014467 phosphorylation site [posttranslational modification] 324057014468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057014469 ATP binding site [chemical binding]; other site 324057014470 Mg2+ binding site [ion binding]; other site 324057014471 G-X-G motif; other site 324057014472 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 324057014473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057014474 motif II; other site 324057014475 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 324057014476 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 324057014477 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 324057014478 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 324057014479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014480 dimer interface [polypeptide binding]; other site 324057014481 conserved gate region; other site 324057014482 ABC-ATPase subunit interface; other site 324057014483 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 324057014484 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 324057014485 Walker A/P-loop; other site 324057014486 ATP binding site [chemical binding]; other site 324057014487 Q-loop/lid; other site 324057014488 ABC transporter signature motif; other site 324057014489 Walker B; other site 324057014490 D-loop; other site 324057014491 H-loop/switch region; other site 324057014492 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 324057014493 Predicted transcriptional regulators [Transcription]; Region: COG1510 324057014494 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057014495 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057014496 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057014497 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057014498 intersubunit interface [polypeptide binding]; other site 324057014499 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 324057014500 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057014501 intersubunit interface [polypeptide binding]; other site 324057014502 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 324057014503 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 324057014504 active site 324057014505 substrate binding site [chemical binding]; other site 324057014506 trimer interface [polypeptide binding]; other site 324057014507 CoA binding site [chemical binding]; other site 324057014508 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 324057014509 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 324057014510 Cupin domain; Region: Cupin_2; pfam07883 324057014511 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057014512 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057014513 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 324057014514 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 324057014515 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 324057014516 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057014517 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057014518 DNA binding residues [nucleotide binding] 324057014519 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057014520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057014521 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 324057014522 putative dimerization interface [polypeptide binding]; other site 324057014523 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057014524 Spore germination protein; Region: Spore_permease; cl17796 324057014525 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057014526 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057014527 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 324057014528 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 324057014529 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057014530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057014531 NAD(P) binding site [chemical binding]; other site 324057014532 active site 324057014533 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057014534 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057014535 active site 324057014536 catalytic tetrad [active] 324057014537 Predicted transcriptional regulators [Transcription]; Region: COG1733 324057014538 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 324057014539 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 324057014540 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 324057014541 Beta-lactamase; Region: Beta-lactamase; pfam00144 324057014542 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 324057014543 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 324057014544 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 324057014545 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 324057014546 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 324057014547 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 324057014548 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 324057014549 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 324057014550 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 324057014551 Phosphoesterase family; Region: Phosphoesterase; pfam04185 324057014552 YusW-like protein; Region: YusW; pfam14039 324057014553 Haemolysin-III related; Region: HlyIII; cl03831 324057014554 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 324057014555 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 324057014556 DinB superfamily; Region: DinB_2; pfam12867 324057014557 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 324057014558 DNA-binding ferritin-like protein (Dps family) [General function prediction only]; Region: COG4817 324057014559 Predicted transcriptional regulators [Transcription]; Region: COG1695 324057014560 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 324057014561 Strictosidine synthase; Region: Str_synth; pfam03088 324057014562 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057014563 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057014564 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 324057014565 putative dimerization interface [polypeptide binding]; other site 324057014566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057014567 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057014568 putative substrate translocation pore; other site 324057014569 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 324057014570 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 324057014571 DNA binding residues [nucleotide binding] 324057014572 dimer interface [polypeptide binding]; other site 324057014573 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 324057014574 dimer interface [polypeptide binding]; other site 324057014575 FMN binding site [chemical binding]; other site 324057014576 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057014577 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057014578 dimerization interface [polypeptide binding]; other site 324057014579 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057014580 dimer interface [polypeptide binding]; other site 324057014581 phosphorylation site [posttranslational modification] 324057014582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057014583 ATP binding site [chemical binding]; other site 324057014584 Mg2+ binding site [ion binding]; other site 324057014585 G-X-G motif; other site 324057014586 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057014587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057014588 active site 324057014589 phosphorylation site [posttranslational modification] 324057014590 intermolecular recognition site; other site 324057014591 dimerization interface [polypeptide binding]; other site 324057014592 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057014593 DNA binding site [nucleotide binding] 324057014594 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324057014595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057014596 S-adenosylmethionine binding site [chemical binding]; other site 324057014597 MarR family; Region: MarR_2; cl17246 324057014598 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057014599 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 324057014600 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324057014601 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324057014602 active site 324057014603 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 324057014604 putative dimer interface [polypeptide binding]; other site 324057014605 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057014606 RibD C-terminal domain; Region: RibD_C; cl17279 324057014607 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 324057014608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057014609 Coenzyme A binding pocket [chemical binding]; other site 324057014610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057014611 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057014612 putative substrate translocation pore; other site 324057014613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057014614 putative substrate translocation pore; other site 324057014615 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057014616 putative DNA binding site [nucleotide binding]; other site 324057014617 dimerization interface [polypeptide binding]; other site 324057014618 putative Zn2+ binding site [ion binding]; other site 324057014619 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 324057014620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 324057014621 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 324057014622 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 324057014623 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 324057014624 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 324057014625 active site 324057014626 substrate binding site [chemical binding]; other site 324057014627 trimer interface [polypeptide binding]; other site 324057014628 CoA binding site [chemical binding]; other site 324057014629 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057014630 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057014631 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057014632 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057014633 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 324057014634 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 324057014635 oligomer interface [polypeptide binding]; other site 324057014636 metal binding site [ion binding]; metal-binding site 324057014637 metal binding site [ion binding]; metal-binding site 324057014638 putative Cl binding site [ion binding]; other site 324057014639 aspartate ring; other site 324057014640 basic sphincter; other site 324057014641 hydrophobic gate; other site 324057014642 periplasmic entrance; other site 324057014643 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324057014644 catalytic core [active] 324057014645 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 324057014646 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057014647 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 324057014648 putative hydrophobic ligand binding site [chemical binding]; other site 324057014649 RNA polymerase factor sigma-70; Validated; Region: PRK08241 324057014650 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057014651 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057014652 DNA binding residues [nucleotide binding] 324057014653 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 324057014654 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 324057014655 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 324057014656 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 324057014657 DNA-binding site [nucleotide binding]; DNA binding site 324057014658 RNA-binding motif; other site 324057014659 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 324057014660 dimer interface [polypeptide binding]; other site 324057014661 FMN binding site [chemical binding]; other site 324057014662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057014663 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057014664 putative substrate translocation pore; other site 324057014665 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 324057014666 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 324057014667 catalytic residues [active] 324057014668 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057014669 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057014670 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057014671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057014672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 324057014673 Transposase; Region: DEDD_Tnp_IS110; pfam01548 324057014674 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 324057014675 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 324057014676 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 324057014677 RNAase interaction site [polypeptide binding]; other site 324057014678 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 324057014679 putative hydrophobic ligand binding site [chemical binding]; other site 324057014680 hypothetical protein; Provisional; Region: PRK06761 324057014681 VanZ like family; Region: VanZ; pfam04892 324057014682 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 324057014683 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 324057014684 S-layer homology domain; Region: SLH; pfam00395 324057014685 S-layer homology domain; Region: SLH; pfam00395 324057014686 S-layer homology domain; Region: SLH; pfam00395 324057014687 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 324057014688 dimanganese center [ion binding]; other site 324057014689 CotJB protein; Region: CotJB; pfam12652 324057014690 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 324057014691 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 324057014692 Domain of unknown function DUF20; Region: UPF0118; pfam01594 324057014693 Radical SAM superfamily; Region: Radical_SAM; pfam04055 324057014694 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057014695 FeS/SAM binding site; other site 324057014696 YfkB-like domain; Region: YfkB; pfam08756 324057014697 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 324057014698 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057014699 Zn2+ binding site [ion binding]; other site 324057014700 Mg2+ binding site [ion binding]; other site 324057014701 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 324057014702 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057014703 active site 324057014704 metal binding site [ion binding]; metal-binding site 324057014705 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 324057014706 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 324057014707 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057014708 FeS/SAM binding site; other site 324057014709 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 324057014710 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 324057014711 MoaE interaction surface [polypeptide binding]; other site 324057014712 MoeB interaction surface [polypeptide binding]; other site 324057014713 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 324057014714 MoaE homodimer interface [polypeptide binding]; other site 324057014715 MoaD interaction [polypeptide binding]; other site 324057014716 active site residues [active] 324057014717 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 324057014718 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057014719 Zn2+ binding site [ion binding]; other site 324057014720 Mg2+ binding site [ion binding]; other site 324057014721 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 324057014722 FeS assembly protein SufB; Region: sufB; TIGR01980 324057014723 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 324057014724 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 324057014725 trimerization site [polypeptide binding]; other site 324057014726 active site 324057014727 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 324057014728 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 324057014729 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057014730 catalytic residue [active] 324057014731 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 324057014732 FeS assembly protein SufD; Region: sufD; TIGR01981 324057014733 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 324057014734 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 324057014735 Walker A/P-loop; other site 324057014736 ATP binding site [chemical binding]; other site 324057014737 Q-loop/lid; other site 324057014738 ABC transporter signature motif; other site 324057014739 Walker B; other site 324057014740 D-loop; other site 324057014741 H-loop/switch region; other site 324057014742 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 324057014743 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 324057014744 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 324057014745 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 324057014746 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 324057014747 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057014748 PAS fold; Region: PAS_4; pfam08448 324057014749 putative active site [active] 324057014750 heme pocket [chemical binding]; other site 324057014751 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 324057014752 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057014753 metal binding site [ion binding]; metal-binding site 324057014754 active site 324057014755 I-site; other site 324057014756 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 324057014757 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 324057014758 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 324057014759 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 324057014760 AAA domain; Region: AAA_23; pfam13476 324057014761 Walker A/P-loop; other site 324057014762 ATP binding site [chemical binding]; other site 324057014763 Q-loop/lid; other site 324057014764 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 324057014765 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057014766 ABC transporter signature motif; other site 324057014767 Walker B; other site 324057014768 D-loop; other site 324057014769 H-loop/switch region; other site 324057014770 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 324057014771 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 324057014772 active site 324057014773 metal binding site [ion binding]; metal-binding site 324057014774 DNA binding site [nucleotide binding] 324057014775 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 324057014776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057014777 putative substrate translocation pore; other site 324057014778 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 324057014779 NADH(P)-binding; Region: NAD_binding_10; pfam13460 324057014780 NAD binding site [chemical binding]; other site 324057014781 substrate binding site [chemical binding]; other site 324057014782 putative active site [active] 324057014783 Rrf2 family protein; Region: rrf2_super; TIGR00738 324057014784 Transcriptional regulator; Region: Rrf2; pfam02082 324057014785 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 324057014786 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324057014787 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057014788 putative DNA binding site [nucleotide binding]; other site 324057014789 putative Zn2+ binding site [ion binding]; other site 324057014790 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 324057014791 short chain dehydrogenase; Provisional; Region: PRK12939 324057014792 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 324057014793 NADP binding site [chemical binding]; other site 324057014794 homodimer interface [polypeptide binding]; other site 324057014795 active site 324057014796 substrate binding site [chemical binding]; other site 324057014797 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 324057014798 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057014799 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 324057014800 putative hydrophobic ligand binding site [chemical binding]; other site 324057014801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057014802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057014803 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057014804 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057014805 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057014806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014807 dimer interface [polypeptide binding]; other site 324057014808 conserved gate region; other site 324057014809 putative PBP binding loops; other site 324057014810 ABC-ATPase subunit interface; other site 324057014811 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057014812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014813 dimer interface [polypeptide binding]; other site 324057014814 conserved gate region; other site 324057014815 ABC-ATPase subunit interface; other site 324057014816 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057014817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057014818 active site 324057014819 phosphorylation site [posttranslational modification] 324057014820 intermolecular recognition site; other site 324057014821 dimerization interface [polypeptide binding]; other site 324057014822 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057014823 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057014824 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057014825 dimerization interface [polypeptide binding]; other site 324057014826 Histidine kinase; Region: His_kinase; pfam06580 324057014827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057014828 ATP binding site [chemical binding]; other site 324057014829 Mg2+ binding site [ion binding]; other site 324057014830 G-X-G motif; other site 324057014831 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 324057014832 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 324057014833 active site 324057014834 catalytic site [active] 324057014835 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 324057014836 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 324057014837 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324057014838 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057014839 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057014840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014841 dimer interface [polypeptide binding]; other site 324057014842 conserved gate region; other site 324057014843 putative PBP binding loops; other site 324057014844 ABC-ATPase subunit interface; other site 324057014845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014846 dimer interface [polypeptide binding]; other site 324057014847 conserved gate region; other site 324057014848 putative PBP binding loops; other site 324057014849 ABC-ATPase subunit interface; other site 324057014850 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 324057014851 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057014852 DNA-binding site [nucleotide binding]; DNA binding site 324057014853 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 324057014854 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057014855 ligand binding site [chemical binding]; other site 324057014856 dimerization interface [polypeptide binding]; other site 324057014857 Domain of unknown function (DUF1793); Region: DUF1793; pfam08760 324057014858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 324057014859 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 324057014860 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 324057014861 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324057014862 active site 324057014863 nucleotide binding site [chemical binding]; other site 324057014864 HIGH motif; other site 324057014865 KMSKS motif; other site 324057014866 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 324057014867 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 324057014868 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 324057014869 nudix motif; other site 324057014870 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 324057014871 Part of AAA domain; Region: AAA_19; pfam13245 324057014872 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 324057014873 AAA domain; Region: AAA_30; pfam13604 324057014874 AAA domain; Region: AAA_12; pfam13087 324057014875 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 324057014876 putative active site [active] 324057014877 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 324057014878 Protein of unknown function DUF45; Region: DUF45; pfam01863 324057014879 Uncharacterized conserved protein [Function unknown]; Region: COG1262 324057014880 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 324057014881 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 324057014882 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 324057014883 S-layer homology domain; Region: SLH; pfam00395 324057014884 S-layer homology domain; Region: SLH; pfam00395 324057014885 S-layer homology domain; Region: SLH; pfam00395 324057014886 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 324057014887 additional DNA contacts [nucleotide binding]; other site 324057014888 mismatch recognition site; other site 324057014889 active site 324057014890 zinc binding site [ion binding]; other site 324057014891 DNA intercalation site [nucleotide binding]; other site 324057014892 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 324057014893 hypothetical protein; Reviewed; Region: PRK09588 324057014894 alpha-galactosidase; Provisional; Region: PRK15076 324057014895 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 324057014896 NAD binding site [chemical binding]; other site 324057014897 sugar binding site [chemical binding]; other site 324057014898 divalent metal binding site [ion binding]; other site 324057014899 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 324057014900 dimer interface [polypeptide binding]; other site 324057014901 Cupin domain; Region: Cupin_2; pfam07883 324057014902 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057014903 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057014904 Uncharacterized conserved protein [Function unknown]; Region: COG3339 324057014905 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 324057014906 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 324057014907 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 324057014908 acyl-activating enzyme (AAE) consensus motif; other site 324057014909 AMP binding site [chemical binding]; other site 324057014910 active site 324057014911 CoA binding site [chemical binding]; other site 324057014912 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 324057014913 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 324057014914 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057014915 sugar binding site [chemical binding]; other site 324057014916 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 324057014917 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 324057014918 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057014919 metal binding site [ion binding]; metal-binding site 324057014920 ligand binding site [chemical binding]; other site 324057014921 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057014922 ligand binding site [chemical binding]; other site 324057014923 metal binding site [ion binding]; metal-binding site 324057014924 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057014925 metal binding site [ion binding]; metal-binding site 324057014926 ligand binding site [chemical binding]; other site 324057014927 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057014928 ligand binding site [chemical binding]; other site 324057014929 S-layer homology domain; Region: SLH; pfam00395 324057014930 S-layer homology domain; Region: SLH; pfam00395 324057014931 S-layer homology domain; Region: SLH; pfam00395 324057014932 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057014933 sugar binding site [chemical binding]; other site 324057014934 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 324057014935 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 324057014936 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057014937 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 324057014938 active site 324057014939 metal binding site [ion binding]; metal-binding site 324057014940 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057014941 Interdomain contacts; other site 324057014942 Cytokine receptor motif; other site 324057014943 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 324057014944 FAD binding site [chemical binding]; other site 324057014945 Protein of unknown function (DUF402); Region: DUF402; cl00979 324057014946 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 324057014947 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057014948 putative active site [active] 324057014949 putative metal binding site [ion binding]; other site 324057014950 S-layer homology domain; Region: SLH; pfam00395 324057014951 S-layer homology domain; Region: SLH; pfam00395 324057014952 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 324057014953 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 324057014954 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 324057014955 hexamer interface [polypeptide binding]; other site 324057014956 ligand binding site [chemical binding]; other site 324057014957 putative active site [active] 324057014958 NAD(P) binding site [chemical binding]; other site 324057014959 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 324057014960 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 324057014961 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 324057014962 phenylhydantoinase; Validated; Region: PRK08323 324057014963 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 324057014964 tetramer interface [polypeptide binding]; other site 324057014965 active site 324057014966 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 324057014967 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 324057014968 homodimer interface [polypeptide binding]; other site 324057014969 active site 324057014970 FMN binding site [chemical binding]; other site 324057014971 substrate binding site [chemical binding]; other site 324057014972 4Fe-4S binding domain; Region: Fer4; pfam00037 324057014973 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 324057014974 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 324057014975 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 324057014976 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057014977 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 324057014978 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 324057014979 active site 324057014980 catalytic triad [active] 324057014981 dimer interface [polypeptide binding]; other site 324057014982 allantoate amidohydrolase; Reviewed; Region: PRK09290 324057014983 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 324057014984 active site 324057014985 metal binding site [ion binding]; metal-binding site 324057014986 dimer interface [polypeptide binding]; other site 324057014987 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 324057014988 NMT1/THI5 like; Region: NMT1; pfam09084 324057014989 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057014990 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 324057014991 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057014992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057014993 dimer interface [polypeptide binding]; other site 324057014994 conserved gate region; other site 324057014995 putative PBP binding loops; other site 324057014996 ABC-ATPase subunit interface; other site 324057014997 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324057014998 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 324057014999 Walker A/P-loop; other site 324057015000 ATP binding site [chemical binding]; other site 324057015001 Q-loop/lid; other site 324057015002 ABC transporter signature motif; other site 324057015003 Walker B; other site 324057015004 D-loop; other site 324057015005 H-loop/switch region; other site 324057015006 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 324057015007 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324057015008 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057015009 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 324057015010 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 324057015011 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057015012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015013 dimer interface [polypeptide binding]; other site 324057015014 conserved gate region; other site 324057015015 putative PBP binding loops; other site 324057015016 ABC-ATPase subunit interface; other site 324057015017 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324057015018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015019 dimer interface [polypeptide binding]; other site 324057015020 conserved gate region; other site 324057015021 putative PBP binding loops; other site 324057015022 ABC-ATPase subunit interface; other site 324057015023 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057015024 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057015025 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057015026 dimerization interface [polypeptide binding]; other site 324057015027 Histidine kinase; Region: His_kinase; pfam06580 324057015028 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 324057015029 ATP binding site [chemical binding]; other site 324057015030 Mg2+ binding site [ion binding]; other site 324057015031 G-X-G motif; other site 324057015032 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057015033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057015034 active site 324057015035 phosphorylation site [posttranslational modification] 324057015036 intermolecular recognition site; other site 324057015037 dimerization interface [polypeptide binding]; other site 324057015038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015039 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 324057015040 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 324057015041 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057015042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057015043 Coenzyme A binding pocket [chemical binding]; other site 324057015044 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 324057015045 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 324057015046 FAD binding domain; Region: FAD_binding_4; pfam01565 324057015047 Berberine and berberine like; Region: BBE; pfam08031 324057015048 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 324057015049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 324057015050 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057015051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057015052 putative substrate translocation pore; other site 324057015053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057015054 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 324057015055 Walker A motif; other site 324057015056 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 324057015057 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 324057015058 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 324057015059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057015060 catalytic residue [active] 324057015061 hypothetical protein; Provisional; Region: PRK08201 324057015062 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 324057015063 metal binding site [ion binding]; metal-binding site 324057015064 putative dimer interface [polypeptide binding]; other site 324057015065 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 324057015066 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 324057015067 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 324057015068 glutaminase A; Region: Gln_ase; TIGR03814 324057015069 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 324057015070 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 324057015071 active site 324057015072 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 324057015073 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 324057015074 generic binding surface I; other site 324057015075 generic binding surface II; other site 324057015076 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057015077 Zn2+ binding site [ion binding]; other site 324057015078 Mg2+ binding site [ion binding]; other site 324057015079 S-layer homology domain; Region: SLH; pfam00395 324057015080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057015081 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 324057015082 putative substrate translocation pore; other site 324057015083 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057015084 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057015085 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057015086 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057015087 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 324057015088 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 324057015089 TPP-binding site [chemical binding]; other site 324057015090 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 324057015091 dimer interface [polypeptide binding]; other site 324057015092 PYR/PP interface [polypeptide binding]; other site 324057015093 TPP binding site [chemical binding]; other site 324057015094 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 324057015095 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 324057015096 E3 interaction surface; other site 324057015097 lipoyl attachment site [posttranslational modification]; other site 324057015098 e3 binding domain; Region: E3_binding; pfam02817 324057015099 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 324057015100 Predicted transcriptional regulator [Transcription]; Region: COG4189 324057015101 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057015102 putative DNA binding site [nucleotide binding]; other site 324057015103 dimerization interface [polypeptide binding]; other site 324057015104 putative Zn2+ binding site [ion binding]; other site 324057015105 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 324057015106 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 324057015107 GAF domain; Region: GAF_2; pfam13185 324057015108 GAF domain; Region: GAF; cl17456 324057015109 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 324057015110 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057015111 metal binding site [ion binding]; metal-binding site 324057015112 active site 324057015113 I-site; other site 324057015114 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 324057015115 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745 324057015116 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 324057015117 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 324057015118 S-layer homology domain; Region: SLH; pfam00395 324057015119 S-layer homology domain; Region: SLH; pfam00395 324057015120 S-layer homology domain; Region: SLH; pfam00395 324057015121 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057015122 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057015123 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057015124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015125 dimer interface [polypeptide binding]; other site 324057015126 ABC-ATPase subunit interface; other site 324057015127 putative PBP binding loops; other site 324057015128 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057015129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015130 dimer interface [polypeptide binding]; other site 324057015131 conserved gate region; other site 324057015132 ABC-ATPase subunit interface; other site 324057015133 Response regulator receiver domain; Region: Response_reg; pfam00072 324057015134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057015135 active site 324057015136 phosphorylation site [posttranslational modification] 324057015137 intermolecular recognition site; other site 324057015138 dimerization interface [polypeptide binding]; other site 324057015139 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057015140 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015141 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057015142 HAMP domain; Region: HAMP; pfam00672 324057015143 dimerization interface [polypeptide binding]; other site 324057015144 Histidine kinase; Region: His_kinase; pfam06580 324057015145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057015146 ATP binding site [chemical binding]; other site 324057015147 Mg2+ binding site [ion binding]; other site 324057015148 G-X-G motif; other site 324057015149 Restriction endonuclease; Region: Mrr_cat; pfam04471 324057015150 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 324057015151 SpoVR like protein; Region: SpoVR; pfam04293 324057015152 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 324057015153 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 324057015154 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 324057015155 HsdM N-terminal domain; Region: HsdM_N; pfam12161 324057015156 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 324057015157 Methyltransferase domain; Region: Methyltransf_26; pfam13659 324057015158 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 324057015159 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 324057015160 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057015161 ATP binding site [chemical binding]; other site 324057015162 putative Mg++ binding site [ion binding]; other site 324057015163 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057015164 nucleotide binding region [chemical binding]; other site 324057015165 ATP-binding site [chemical binding]; other site 324057015166 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 324057015167 putative active site [active] 324057015168 DEAD-like helicases superfamily; Region: DEXDc; smart00487 324057015169 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057015170 ATP binding site [chemical binding]; other site 324057015171 putative Mg++ binding site [ion binding]; other site 324057015172 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057015173 nucleotide binding region [chemical binding]; other site 324057015174 ATP-binding site [chemical binding]; other site 324057015175 NAD-dependent deacetylase; Provisional; Region: PRK00481 324057015176 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 324057015177 Predicted transcriptional regulator [Transcription]; Region: COG2378 324057015178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 324057015179 WYL domain; Region: WYL; pfam13280 324057015180 E2 (early) protein, N terminal; Region: PPV_E2_N; pfam00508 324057015181 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 324057015182 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 324057015183 catalytic residues [active] 324057015184 catalytic nucleophile [active] 324057015185 Presynaptic Site I dimer interface [polypeptide binding]; other site 324057015186 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 324057015187 Synaptic Flat tetramer interface [polypeptide binding]; other site 324057015188 Recombinase; Region: Recombinase; pfam07508 324057015189 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 324057015190 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 324057015191 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324057015192 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057015193 non-specific DNA binding site [nucleotide binding]; other site 324057015194 salt bridge; other site 324057015195 sequence-specific DNA binding site [nucleotide binding]; other site 324057015196 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 324057015197 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 324057015198 catalytic residues [active] 324057015199 catalytic nucleophile [active] 324057015200 Recombinase; Region: Recombinase; pfam07508 324057015201 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 324057015202 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 324057015203 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 324057015204 catalytic residues [active] 324057015205 catalytic nucleophile [active] 324057015206 Recombinase; Region: Recombinase; pfam07508 324057015207 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 324057015208 catalytic residues [active] 324057015209 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 324057015210 active site 324057015211 AAA domain; Region: AAA_21; pfam13304 324057015212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057015213 Q-loop/lid; other site 324057015214 ABC transporter signature motif; other site 324057015215 Walker B; other site 324057015216 D-loop; other site 324057015217 H-loop/switch region; other site 324057015218 Restriction endonuclease; Region: Mrr_cat; pfam04471 324057015219 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 324057015220 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 324057015221 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 324057015222 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 324057015223 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 324057015224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 324057015225 Uncharacterized conserved protein [Function unknown]; Region: COG2308 324057015226 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 324057015227 heme-binding site [chemical binding]; other site 324057015228 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057015229 dimer interface [polypeptide binding]; other site 324057015230 putative CheW interface [polypeptide binding]; other site 324057015231 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 324057015232 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 324057015233 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 324057015234 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 324057015235 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057015236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057015237 homodimer interface [polypeptide binding]; other site 324057015238 catalytic residue [active] 324057015239 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 324057015240 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 324057015241 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057015242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057015243 active site 324057015244 phosphorylation site [posttranslational modification] 324057015245 intermolecular recognition site; other site 324057015246 dimerization interface [polypeptide binding]; other site 324057015247 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057015248 DNA binding site [nucleotide binding] 324057015249 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 324057015250 homodimer interface [polypeptide binding]; other site 324057015251 substrate-cofactor binding pocket; other site 324057015252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057015253 catalytic residue [active] 324057015254 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 324057015255 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 324057015256 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 324057015257 glutamine synthetase, type I; Region: GlnA; TIGR00653 324057015258 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 324057015259 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 324057015260 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 324057015261 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 324057015262 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 324057015263 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 324057015264 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057015265 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057015266 dimerization interface [polypeptide binding]; other site 324057015267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057015268 dimer interface [polypeptide binding]; other site 324057015269 phosphorylation site [posttranslational modification] 324057015270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057015271 ATP binding site [chemical binding]; other site 324057015272 Mg2+ binding site [ion binding]; other site 324057015273 G-X-G motif; other site 324057015274 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057015275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057015276 active site 324057015277 phosphorylation site [posttranslational modification] 324057015278 intermolecular recognition site; other site 324057015279 dimerization interface [polypeptide binding]; other site 324057015280 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057015281 DNA binding site [nucleotide binding] 324057015282 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 324057015283 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 324057015284 protein binding site [polypeptide binding]; other site 324057015285 YugN-like family; Region: YugN; pfam08868 324057015286 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057015287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057015288 active site 324057015289 phosphorylation site [posttranslational modification] 324057015290 intermolecular recognition site; other site 324057015291 dimerization interface [polypeptide binding]; other site 324057015292 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057015293 DNA binding residues [nucleotide binding] 324057015294 dimerization interface [polypeptide binding]; other site 324057015295 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324057015296 HAMP domain; Region: HAMP; pfam00672 324057015297 Histidine kinase; Region: HisKA_3; pfam07730 324057015298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057015299 ATP binding site [chemical binding]; other site 324057015300 Mg2+ binding site [ion binding]; other site 324057015301 G-X-G motif; other site 324057015302 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 324057015303 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 324057015304 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 324057015305 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 324057015306 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 324057015307 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 324057015308 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 324057015309 active site 324057015310 dimer interface [polypeptide binding]; other site 324057015311 motif 1; other site 324057015312 motif 2; other site 324057015313 motif 3; other site 324057015314 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 324057015315 anticodon binding site; other site 324057015316 YtxC-like family; Region: YtxC; pfam08812 324057015317 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 324057015318 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 324057015319 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057015320 FeS/SAM binding site; other site 324057015321 cystathionine beta-lyase; Provisional; Region: PRK08064 324057015322 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 324057015323 homodimer interface [polypeptide binding]; other site 324057015324 substrate-cofactor binding pocket; other site 324057015325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057015326 catalytic residue [active] 324057015327 cystathionine gamma-synthase; Reviewed; Region: PRK08247 324057015328 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 324057015329 homodimer interface [polypeptide binding]; other site 324057015330 substrate-cofactor binding pocket; other site 324057015331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057015332 catalytic residue [active] 324057015333 Homoserine O-succinyltransferase; Region: HTS; pfam04204 324057015334 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 324057015335 proposed active site lysine [active] 324057015336 conserved cys residue [active] 324057015337 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 324057015338 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 324057015339 oligomer interface [polypeptide binding]; other site 324057015340 metal binding site [ion binding]; metal-binding site 324057015341 metal binding site [ion binding]; metal-binding site 324057015342 putative Cl binding site [ion binding]; other site 324057015343 aspartate ring; other site 324057015344 basic sphincter; other site 324057015345 hydrophobic gate; other site 324057015346 periplasmic entrance; other site 324057015347 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 324057015348 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 324057015349 dimer interface [polypeptide binding]; other site 324057015350 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057015351 catalytic residue [active] 324057015352 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 324057015353 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057015354 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057015355 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057015356 dimerization interface [polypeptide binding]; other site 324057015357 histidinol-phosphatase; Provisional; Region: PRK07328 324057015358 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 324057015359 active site 324057015360 dimer interface [polypeptide binding]; other site 324057015361 Predicted membrane protein [Function unknown]; Region: COG2259 324057015362 Predicted transcriptional regulators [Transcription]; Region: COG1733 324057015363 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 324057015364 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 324057015365 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 324057015366 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 324057015367 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 324057015368 L-aspartate oxidase; Provisional; Region: PRK06175 324057015369 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 324057015370 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 324057015371 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 324057015372 putative Iron-sulfur protein interface [polypeptide binding]; other site 324057015373 proximal heme binding site [chemical binding]; other site 324057015374 distal heme binding site [chemical binding]; other site 324057015375 putative dimer interface [polypeptide binding]; other site 324057015376 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057015377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057015378 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057015379 dimerization interface [polypeptide binding]; other site 324057015380 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 324057015381 TrkA-N domain; Region: TrkA_N; pfam02254 324057015382 TrkA-C domain; Region: TrkA_C; pfam02080 324057015383 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 324057015384 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 324057015385 CAAX protease self-immunity; Region: Abi; pfam02517 324057015386 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 324057015387 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 324057015388 GIY-YIG motif/motif A; other site 324057015389 active site 324057015390 catalytic site [active] 324057015391 putative DNA binding site [nucleotide binding]; other site 324057015392 metal binding site [ion binding]; metal-binding site 324057015393 UvrB/uvrC motif; Region: UVR; pfam02151 324057015394 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 324057015395 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 324057015396 DNA binding site [nucleotide binding] 324057015397 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 324057015398 sulfate transport protein; Provisional; Region: cysT; CHL00187 324057015399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015400 dimer interface [polypeptide binding]; other site 324057015401 conserved gate region; other site 324057015402 putative PBP binding loops; other site 324057015403 ABC-ATPase subunit interface; other site 324057015404 sulfate transport protein; Provisional; Region: cysT; CHL00187 324057015405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015406 dimer interface [polypeptide binding]; other site 324057015407 conserved gate region; other site 324057015408 putative PBP binding loops; other site 324057015409 ABC-ATPase subunit interface; other site 324057015410 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 324057015411 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 324057015412 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 324057015413 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324057015414 Walker A/P-loop; other site 324057015415 ATP binding site [chemical binding]; other site 324057015416 Q-loop/lid; other site 324057015417 ABC transporter signature motif; other site 324057015418 Walker B; other site 324057015419 D-loop; other site 324057015420 H-loop/switch region; other site 324057015421 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 324057015422 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 324057015423 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324057015424 Walker A/P-loop; other site 324057015425 ATP binding site [chemical binding]; other site 324057015426 Q-loop/lid; other site 324057015427 ABC transporter signature motif; other site 324057015428 Walker B; other site 324057015429 D-loop; other site 324057015430 H-loop/switch region; other site 324057015431 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 324057015432 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 324057015433 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 324057015434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015435 dimer interface [polypeptide binding]; other site 324057015436 conserved gate region; other site 324057015437 putative PBP binding loops; other site 324057015438 ABC-ATPase subunit interface; other site 324057015439 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 324057015440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015441 dimer interface [polypeptide binding]; other site 324057015442 conserved gate region; other site 324057015443 putative PBP binding loops; other site 324057015444 ABC-ATPase subunit interface; other site 324057015445 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 324057015446 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 324057015447 primosomal protein DnaI; Reviewed; Region: PRK08939 324057015448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057015449 Walker A motif; other site 324057015450 ATP binding site [chemical binding]; other site 324057015451 Walker B motif; other site 324057015452 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 324057015453 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 324057015454 Putative membrane protein; Region: YuiB; pfam14068 324057015455 putative heme peroxidase; Provisional; Region: PRK12276 324057015456 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 324057015457 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057015458 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 324057015459 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 324057015460 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057015461 Sporulation inhibitor A; Region: Sda; pfam08970 324057015462 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 324057015463 DNA topoisomerase III; Provisional; Region: PRK07726 324057015464 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 324057015465 active site 324057015466 putative interdomain interaction site [polypeptide binding]; other site 324057015467 putative metal-binding site [ion binding]; other site 324057015468 putative nucleotide binding site [chemical binding]; other site 324057015469 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 324057015470 domain I; other site 324057015471 DNA binding groove [nucleotide binding] 324057015472 phosphate binding site [ion binding]; other site 324057015473 domain II; other site 324057015474 domain III; other site 324057015475 nucleotide binding site [chemical binding]; other site 324057015476 catalytic site [active] 324057015477 domain IV; other site 324057015478 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 324057015479 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 324057015480 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057015481 putative active site [active] 324057015482 putative metal binding site [ion binding]; other site 324057015483 endonuclease subunit; Provisional; Region: 46; PHA02562 324057015484 FtsX-like permease family; Region: FtsX; pfam02687 324057015485 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 324057015486 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057015487 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 324057015488 Walker A/P-loop; other site 324057015489 ATP binding site [chemical binding]; other site 324057015490 Q-loop/lid; other site 324057015491 ABC transporter signature motif; other site 324057015492 Walker B; other site 324057015493 D-loop; other site 324057015494 H-loop/switch region; other site 324057015495 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057015496 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057015497 dimer interface [polypeptide binding]; other site 324057015498 phosphorylation site [posttranslational modification] 324057015499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057015500 ATP binding site [chemical binding]; other site 324057015501 Mg2+ binding site [ion binding]; other site 324057015502 G-X-G motif; other site 324057015503 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057015504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057015505 active site 324057015506 phosphorylation site [posttranslational modification] 324057015507 intermolecular recognition site; other site 324057015508 dimerization interface [polypeptide binding]; other site 324057015509 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057015510 DNA binding site [nucleotide binding] 324057015511 translocation protein TolB; Provisional; Region: tolB; PRK04922 324057015512 PBP superfamily domain; Region: PBP_like_2; cl17296 324057015513 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 324057015514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015515 dimer interface [polypeptide binding]; other site 324057015516 conserved gate region; other site 324057015517 putative PBP binding loops; other site 324057015518 ABC-ATPase subunit interface; other site 324057015519 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 324057015520 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015521 dimer interface [polypeptide binding]; other site 324057015522 conserved gate region; other site 324057015523 putative PBP binding loops; other site 324057015524 ABC-ATPase subunit interface; other site 324057015525 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 324057015526 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 324057015527 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057015528 FeS/SAM binding site; other site 324057015529 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 324057015530 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057015531 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 324057015532 NifU-like domain; Region: NifU; cl00484 324057015533 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 324057015534 classical (c) SDRs; Region: SDR_c; cd05233 324057015535 NAD(P) binding site [chemical binding]; other site 324057015536 active site 324057015537 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 324057015538 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 324057015539 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 324057015540 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 324057015541 catalytic residues [active] 324057015542 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057015543 stage V sporulation protein B; Region: spore_V_B; TIGR02900 324057015544 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 324057015545 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 324057015546 conserved cys residue [active] 324057015547 Protein of unknown function (DUF456); Region: DUF456; cl01069 324057015548 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 324057015549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057015550 active site 324057015551 motif I; other site 324057015552 motif II; other site 324057015553 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 324057015554 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057015555 ABC-ATPase subunit interface; other site 324057015556 dimer interface [polypeptide binding]; other site 324057015557 putative PBP binding regions; other site 324057015558 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 324057015559 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057015560 ABC-ATPase subunit interface; other site 324057015561 dimer interface [polypeptide binding]; other site 324057015562 putative PBP binding regions; other site 324057015563 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 324057015564 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 324057015565 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 324057015566 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057015567 intersubunit interface [polypeptide binding]; other site 324057015568 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 324057015569 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 324057015570 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 324057015571 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 324057015572 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 324057015573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057015574 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057015575 putative substrate translocation pore; other site 324057015576 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 324057015577 active site 324057015578 metal binding site [ion binding]; metal-binding site 324057015579 Predicted permeases [General function prediction only]; Region: COG0679 324057015580 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 324057015581 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 324057015582 Cu(I) binding site [ion binding]; other site 324057015583 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 324057015584 UbiA prenyltransferase family; Region: UbiA; pfam01040 324057015585 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 324057015586 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 324057015587 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 324057015588 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 324057015589 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 324057015590 active site 324057015591 HIGH motif; other site 324057015592 dimer interface [polypeptide binding]; other site 324057015593 KMSKS motif; other site 324057015594 Predicted permeases [General function prediction only]; Region: COG0701 324057015595 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 324057015596 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057015597 dimerization interface [polypeptide binding]; other site 324057015598 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057015599 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057015600 dimer interface [polypeptide binding]; other site 324057015601 putative CheW interface [polypeptide binding]; other site 324057015602 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 324057015603 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 324057015604 NodB motif; other site 324057015605 active site 324057015606 catalytic site [active] 324057015607 metal binding site [ion binding]; metal-binding site 324057015608 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057015609 3D domain; Region: 3D; cl01439 324057015610 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 324057015611 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 324057015612 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057015613 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057015614 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057015615 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057015616 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 324057015617 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 324057015618 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057015619 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 324057015620 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 324057015621 active site residue [active] 324057015622 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 324057015623 CPxP motif; other site 324057015624 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 324057015625 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057015626 dimerization interface [polypeptide binding]; other site 324057015627 putative DNA binding site [nucleotide binding]; other site 324057015628 putative Zn2+ binding site [ion binding]; other site 324057015629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057015630 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057015631 putative substrate translocation pore; other site 324057015632 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057015633 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057015634 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057015636 WHG domain; Region: WHG; pfam13305 324057015637 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 324057015638 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057015639 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324057015640 Coenzyme A binding pocket [chemical binding]; other site 324057015641 IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330 324057015642 Phosphotransferase enzyme family; Region: APH; pfam01636 324057015643 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 324057015644 active site 324057015645 ATP binding site [chemical binding]; other site 324057015646 substrate binding site [chemical binding]; other site 324057015647 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 324057015648 nudix motif; other site 324057015649 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 324057015650 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057015651 motif II; other site 324057015652 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 324057015653 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 324057015654 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 324057015655 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 324057015656 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324057015657 Coenzyme A binding pocket [chemical binding]; other site 324057015658 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 324057015659 nudix motif; other site 324057015660 HEAT repeats; Region: HEAT_2; pfam13646 324057015661 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 324057015662 AAA domain; Region: AAA_17; pfam13207 324057015663 AAA domain; Region: AAA_33; pfam13671 324057015664 allophanate hydrolase; Provisional; Region: PRK08186 324057015665 Amidase; Region: Amidase; cl11426 324057015666 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 324057015667 DRTGG domain; Region: DRTGG; pfam07085 324057015668 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 324057015669 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 324057015670 Cupin domain; Region: Cupin_2; pfam07883 324057015671 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663 324057015672 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057015673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057015674 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324057015675 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 324057015676 Walker A/P-loop; other site 324057015677 ATP binding site [chemical binding]; other site 324057015678 Q-loop/lid; other site 324057015679 ABC transporter signature motif; other site 324057015680 Walker B; other site 324057015681 D-loop; other site 324057015682 H-loop/switch region; other site 324057015683 NMT1/THI5 like; Region: NMT1; pfam09084 324057015684 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324057015685 substrate binding pocket [chemical binding]; other site 324057015686 membrane-bound complex binding site; other site 324057015687 Isochorismatase family; Region: Isochorismatase; pfam00857 324057015688 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 324057015689 catalytic triad [active] 324057015690 conserved cis-peptide bond; other site 324057015691 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057015692 Coenzyme A binding pocket [chemical binding]; other site 324057015693 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 324057015694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057015695 Coenzyme A binding pocket [chemical binding]; other site 324057015696 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 324057015697 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324057015698 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 324057015699 Phosphotransferase enzyme family; Region: APH; pfam01636 324057015700 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 324057015701 active site 324057015702 substrate binding site [chemical binding]; other site 324057015703 ATP binding site [chemical binding]; other site 324057015704 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057015705 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 324057015706 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057015707 Coenzyme A binding pocket [chemical binding]; other site 324057015708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 324057015709 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 324057015710 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 324057015711 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057015712 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057015713 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015714 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057015715 Helix-turn-helix domain; Region: HTH_18; pfam12833 324057015716 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015717 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057015718 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 324057015719 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057015720 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057015721 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057015722 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057015723 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057015724 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057015725 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 324057015726 amidase catalytic site [active] 324057015727 Zn binding residues [ion binding]; other site 324057015728 substrate binding site [chemical binding]; other site 324057015729 azoreductase; Provisional; Region: PRK13556 324057015730 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057015731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057015732 active site 324057015733 phosphorylation site [posttranslational modification] 324057015734 intermolecular recognition site; other site 324057015735 dimerization interface [polypeptide binding]; other site 324057015736 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057015737 DNA binding residues [nucleotide binding] 324057015738 dimerization interface [polypeptide binding]; other site 324057015739 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 324057015740 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 324057015741 GAF domain; Region: GAF_3; pfam13492 324057015742 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324057015743 Histidine kinase; Region: HisKA_3; pfam07730 324057015744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057015745 ATP binding site [chemical binding]; other site 324057015746 Mg2+ binding site [ion binding]; other site 324057015747 G-X-G motif; other site 324057015748 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 324057015749 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 324057015750 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 324057015751 WYL domain; Region: WYL; pfam13280 324057015752 WYL domain; Region: WYL; pfam13280 324057015753 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 324057015754 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 324057015755 dimer interface [polypeptide binding]; other site 324057015756 active site 324057015757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057015758 salt bridge; other site 324057015759 non-specific DNA binding site [nucleotide binding]; other site 324057015760 sequence-specific DNA binding site [nucleotide binding]; other site 324057015761 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 324057015762 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 324057015763 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 324057015764 putative active site [active] 324057015765 putative metal binding site [ion binding]; other site 324057015766 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057015767 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057015768 translocation protein TolB; Provisional; Region: tolB; PRK02889 324057015769 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057015770 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057015771 dimerization interface [polypeptide binding]; other site 324057015772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057015773 dimer interface [polypeptide binding]; other site 324057015774 phosphorylation site [posttranslational modification] 324057015775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057015776 ATP binding site [chemical binding]; other site 324057015777 Mg2+ binding site [ion binding]; other site 324057015778 G-X-G motif; other site 324057015779 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057015780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057015781 active site 324057015782 phosphorylation site [posttranslational modification] 324057015783 intermolecular recognition site; other site 324057015784 dimerization interface [polypeptide binding]; other site 324057015785 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057015786 DNA binding site [nucleotide binding] 324057015787 hypothetical protein; Provisional; Region: PRK04351 324057015788 SprT homologues; Region: SprT; cl01182 324057015789 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 324057015790 dimer interface [polypeptide binding]; other site 324057015791 FMN binding site [chemical binding]; other site 324057015792 Rrf2 family protein; Region: rrf2_super; TIGR00738 324057015793 Transcriptional regulator; Region: Rrf2; pfam02082 324057015794 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 324057015795 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 324057015796 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 324057015797 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 324057015798 RNA binding site [nucleotide binding]; other site 324057015799 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 324057015800 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 324057015801 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 324057015802 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 324057015803 S-layer homology domain; Region: SLH; pfam00395 324057015804 Small acid-soluble spore protein H family; Region: SspH; cl06949 324057015805 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 324057015806 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 324057015807 putative DNA binding site [nucleotide binding]; other site 324057015808 putative homodimer interface [polypeptide binding]; other site 324057015809 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 324057015810 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 324057015811 active site 324057015812 DNA binding site [nucleotide binding] 324057015813 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 324057015814 DNA binding site [nucleotide binding] 324057015815 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 324057015816 nucleotide binding site [chemical binding]; other site 324057015817 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 324057015818 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 324057015819 putative active site [active] 324057015820 catalytic site [active] 324057015821 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 324057015822 putative active site [active] 324057015823 catalytic site [active] 324057015824 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 324057015825 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 324057015826 NADP binding site [chemical binding]; other site 324057015827 active site 324057015828 putative substrate binding site [chemical binding]; other site 324057015829 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 324057015830 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 324057015831 NAD binding site [chemical binding]; other site 324057015832 substrate binding site [chemical binding]; other site 324057015833 homodimer interface [polypeptide binding]; other site 324057015834 active site 324057015835 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 324057015836 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 324057015837 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 324057015838 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324057015839 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057015840 Walker A/P-loop; other site 324057015841 ATP binding site [chemical binding]; other site 324057015842 Q-loop/lid; other site 324057015843 ABC transporter signature motif; other site 324057015844 Walker B; other site 324057015845 D-loop; other site 324057015846 H-loop/switch region; other site 324057015847 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 324057015848 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057015849 active site 324057015850 Cupin domain; Region: Cupin_2; cl17218 324057015851 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 324057015852 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 324057015853 PilZ domain; Region: PilZ; pfam07238 324057015854 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324057015855 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057015856 non-specific DNA binding site [nucleotide binding]; other site 324057015857 salt bridge; other site 324057015858 sequence-specific DNA binding site [nucleotide binding]; other site 324057015859 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 324057015860 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 324057015861 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 324057015862 active site 324057015863 dimer interface [polypeptide binding]; other site 324057015864 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 324057015865 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 324057015866 active site 324057015867 FMN binding site [chemical binding]; other site 324057015868 substrate binding site [chemical binding]; other site 324057015869 3Fe-4S cluster binding site [ion binding]; other site 324057015870 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 324057015871 domain interface; other site 324057015872 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 324057015873 active site 324057015874 catalytic triad [active] 324057015875 oxyanion hole [active] 324057015876 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057015877 Kinase associated protein B; Region: KapB; pfam08810 324057015878 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 324057015879 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 324057015880 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 324057015881 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 324057015882 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 324057015883 Malic enzyme, N-terminal domain; Region: malic; pfam00390 324057015884 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 324057015885 putative NAD(P) binding site [chemical binding]; other site 324057015886 Acyltransferase family; Region: Acyl_transf_3; pfam01757 324057015887 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 324057015888 putative active site [active] 324057015889 putative metal binding site [ion binding]; other site 324057015890 Acyltransferase family; Region: Acyl_transf_3; pfam01757 324057015891 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 324057015892 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 324057015893 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 324057015894 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324057015895 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324057015896 ABC transporter; Region: ABC_tran_2; pfam12848 324057015897 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324057015898 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057015899 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057015900 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057015901 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 324057015902 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324057015903 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 324057015904 Virulence factor; Region: Virulence_fact; pfam13769 324057015905 HEAT repeats; Region: HEAT_2; pfam13646 324057015906 HEAT repeats; Region: HEAT_2; pfam13646 324057015907 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 324057015908 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 324057015909 Sulfatase; Region: Sulfatase; pfam00884 324057015910 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324057015911 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057015912 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 324057015913 Glycosyl hydrolase families 43 and 62 form CAZY clan GH-F; Region: GH_F; cd08978 324057015914 active site 324057015915 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057015916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015917 dimer interface [polypeptide binding]; other site 324057015918 conserved gate region; other site 324057015919 putative PBP binding loops; other site 324057015920 ABC-ATPase subunit interface; other site 324057015921 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057015922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015923 dimer interface [polypeptide binding]; other site 324057015924 conserved gate region; other site 324057015925 putative PBP binding loops; other site 324057015926 ABC-ATPase subunit interface; other site 324057015927 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057015928 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057015929 Predicted transcriptional regulator [Transcription]; Region: COG4189 324057015930 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057015931 dimerization interface [polypeptide binding]; other site 324057015932 putative DNA binding site [nucleotide binding]; other site 324057015933 putative Zn2+ binding site [ion binding]; other site 324057015934 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057015935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057015936 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057015937 dimerization interface [polypeptide binding]; other site 324057015938 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 324057015939 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057015940 MarR family; Region: MarR; pfam01047 324057015941 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057015942 Coenzyme A binding pocket [chemical binding]; other site 324057015943 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 324057015944 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 324057015945 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 324057015946 active site 324057015947 catalytic residues [active] 324057015948 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 324057015949 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 324057015950 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057015951 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057015952 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 324057015953 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 324057015954 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 324057015955 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057015956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015957 dimer interface [polypeptide binding]; other site 324057015958 conserved gate region; other site 324057015959 putative PBP binding loops; other site 324057015960 ABC-ATPase subunit interface; other site 324057015961 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057015962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015963 dimer interface [polypeptide binding]; other site 324057015964 conserved gate region; other site 324057015965 putative PBP binding loops; other site 324057015966 ABC-ATPase subunit interface; other site 324057015967 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057015968 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057015969 Uncharacterized conserved protein [Function unknown]; Region: COG3538 324057015970 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 324057015971 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057015972 DNA-binding site [nucleotide binding]; DNA binding site 324057015973 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057015974 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057015975 dimerization interface [polypeptide binding]; other site 324057015976 ligand binding site [chemical binding]; other site 324057015977 C factor cell-cell signaling protein; Provisional; Region: PRK09009 324057015978 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 324057015979 NADP binding site [chemical binding]; other site 324057015980 homodimer interface [polypeptide binding]; other site 324057015981 active site 324057015982 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 324057015983 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 324057015984 putative metal binding site [ion binding]; other site 324057015985 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 324057015986 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057015987 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 324057015988 putative metal binding site [ion binding]; other site 324057015989 S-layer homology domain; Region: SLH; pfam00395 324057015990 S-layer homology domain; Region: SLH; pfam00395 324057015991 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057015992 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057015993 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057015994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015995 ABC-ATPase subunit interface; other site 324057015996 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057015997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057015998 dimer interface [polypeptide binding]; other site 324057015999 conserved gate region; other site 324057016000 ABC-ATPase subunit interface; other site 324057016001 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057016002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057016003 active site 324057016004 phosphorylation site [posttranslational modification] 324057016005 intermolecular recognition site; other site 324057016006 dimerization interface [polypeptide binding]; other site 324057016007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016009 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057016010 dimerization interface [polypeptide binding]; other site 324057016011 Histidine kinase; Region: His_kinase; pfam06580 324057016012 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 324057016013 ATP binding site [chemical binding]; other site 324057016014 Mg2+ binding site [ion binding]; other site 324057016015 G-X-G motif; other site 324057016016 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057016017 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057016018 DNA binding site [nucleotide binding] 324057016019 domain linker motif; other site 324057016020 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057016021 dimerization interface [polypeptide binding]; other site 324057016022 ligand binding site [chemical binding]; other site 324057016023 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 324057016024 conserved cys residue [active] 324057016025 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057016026 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057016027 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057016028 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057016029 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057016030 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016031 Sensory domain found in PocR; Region: PocR; pfam10114 324057016032 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 324057016033 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057016034 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016035 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 324057016036 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 324057016037 dimer interface [polypeptide binding]; other site 324057016038 active site 324057016039 metal binding site [ion binding]; metal-binding site 324057016040 dihydroxyacetone kinase; Provisional; Region: PRK14479 324057016041 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 324057016042 DAK2 domain; Region: Dak2; pfam02734 324057016043 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 324057016044 classical (c) SDRs; Region: SDR_c; cd05233 324057016045 NAD(P) binding site [chemical binding]; other site 324057016046 active site 324057016047 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 324057016048 active site 324057016049 catalytic residues [active] 324057016050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057016051 TPR motif; other site 324057016052 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324057016053 binding surface 324057016054 TPR repeat; Region: TPR_11; pfam13414 324057016055 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057016056 binding surface 324057016057 TPR motif; other site 324057016058 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057016059 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057016060 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016061 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 324057016062 Melibiase; Region: Melibiase; pfam02065 324057016063 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 324057016064 Sulfatase; Region: Sulfatase; cl17466 324057016065 Response regulator receiver domain; Region: Response_reg; pfam00072 324057016066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057016067 active site 324057016068 phosphorylation site [posttranslational modification] 324057016069 intermolecular recognition site; other site 324057016070 dimerization interface [polypeptide binding]; other site 324057016071 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016072 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057016073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016074 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057016075 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057016076 dimerization interface [polypeptide binding]; other site 324057016077 Histidine kinase; Region: His_kinase; pfam06580 324057016078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057016079 ATP binding site [chemical binding]; other site 324057016080 Mg2+ binding site [ion binding]; other site 324057016081 G-X-G motif; other site 324057016082 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016083 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057016084 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057016085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016086 dimer interface [polypeptide binding]; other site 324057016087 conserved gate region; other site 324057016088 putative PBP binding loops; other site 324057016089 ABC-ATPase subunit interface; other site 324057016090 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057016091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016092 dimer interface [polypeptide binding]; other site 324057016093 conserved gate region; other site 324057016094 ABC-ATPase subunit interface; other site 324057016095 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324057016096 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 324057016097 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057016098 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057016099 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057016100 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016101 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057016102 Histidine kinase; Region: His_kinase; pfam06580 324057016103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057016104 ATP binding site [chemical binding]; other site 324057016105 Mg2+ binding site [ion binding]; other site 324057016106 G-X-G motif; other site 324057016107 Response regulator receiver domain; Region: Response_reg; pfam00072 324057016108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057016109 active site 324057016110 phosphorylation site [posttranslational modification] 324057016111 intermolecular recognition site; other site 324057016112 dimerization interface [polypeptide binding]; other site 324057016113 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057016114 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016115 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 324057016116 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057016117 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016118 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057016119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016120 dimer interface [polypeptide binding]; other site 324057016121 conserved gate region; other site 324057016122 putative PBP binding loops; other site 324057016123 ABC-ATPase subunit interface; other site 324057016124 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057016125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016126 dimer interface [polypeptide binding]; other site 324057016127 conserved gate region; other site 324057016128 putative PBP binding loops; other site 324057016129 ABC-ATPase subunit interface; other site 324057016130 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 324057016131 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 324057016132 active site 324057016133 FMN binding site [chemical binding]; other site 324057016134 substrate binding site [chemical binding]; other site 324057016135 homotetramer interface [polypeptide binding]; other site 324057016136 catalytic residue [active] 324057016137 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057016138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057016139 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057016140 Right handed beta helix region; Region: Beta_helix; pfam13229 324057016141 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057016142 sugar binding site [chemical binding]; other site 324057016143 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057016144 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 324057016145 sugar binding site [chemical binding]; other site 324057016146 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057016147 Interdomain contacts; other site 324057016148 Cytokine receptor motif; other site 324057016149 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 324057016150 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057016151 sugar binding site [chemical binding]; other site 324057016152 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057016153 sugar binding site [chemical binding]; other site 324057016154 S-layer homology domain; Region: SLH; pfam00395 324057016155 S-layer homology domain; Region: SLH; pfam00395 324057016156 S-layer homology domain; Region: SLH; pfam00395 324057016157 Domain of unknown function (DUF377); Region: DUF377; pfam04041 324057016158 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 324057016159 active site 324057016160 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057016161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016162 dimer interface [polypeptide binding]; other site 324057016163 conserved gate region; other site 324057016164 putative PBP binding loops; other site 324057016165 ABC-ATPase subunit interface; other site 324057016166 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 324057016167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016168 dimer interface [polypeptide binding]; other site 324057016169 conserved gate region; other site 324057016170 putative PBP binding loops; other site 324057016171 ABC-ATPase subunit interface; other site 324057016172 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016173 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 324057016174 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057016175 dimerization interface [polypeptide binding]; other site 324057016176 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 324057016177 Histidine kinase; Region: His_kinase; pfam06580 324057016178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057016179 ATP binding site [chemical binding]; other site 324057016180 Mg2+ binding site [ion binding]; other site 324057016181 G-X-G motif; other site 324057016182 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057016183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057016184 active site 324057016185 phosphorylation site [posttranslational modification] 324057016186 intermolecular recognition site; other site 324057016187 dimerization interface [polypeptide binding]; other site 324057016188 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016189 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 324057016190 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 324057016191 Predicted transcriptional regulator [Transcription]; Region: COG1959 324057016192 Transcriptional regulator; Region: Rrf2; pfam02082 324057016193 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057016194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057016195 NADH(P)-binding; Region: NAD_binding_10; pfam13460 324057016196 NAD(P) binding site [chemical binding]; other site 324057016197 active site 324057016198 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057016199 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057016200 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057016201 Spore germination protein; Region: Spore_permease; cl17796 324057016202 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 324057016203 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 324057016204 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 324057016205 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 324057016206 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057016207 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057016208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016209 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016210 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057016211 MarR family; Region: MarR; pfam01047 324057016212 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 324057016213 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 324057016214 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324057016215 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 324057016216 Walker A/P-loop; other site 324057016217 ATP binding site [chemical binding]; other site 324057016218 Q-loop/lid; other site 324057016219 ABC transporter signature motif; other site 324057016220 Walker B; other site 324057016221 D-loop; other site 324057016222 H-loop/switch region; other site 324057016223 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057016224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016225 dimer interface [polypeptide binding]; other site 324057016226 conserved gate region; other site 324057016227 putative PBP binding loops; other site 324057016228 ABC-ATPase subunit interface; other site 324057016229 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 324057016230 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016231 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057016232 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057016233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016234 dimer interface [polypeptide binding]; other site 324057016235 putative PBP binding loops; other site 324057016236 ABC-ATPase subunit interface; other site 324057016237 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057016238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016239 dimer interface [polypeptide binding]; other site 324057016240 conserved gate region; other site 324057016241 putative PBP binding loops; other site 324057016242 ABC-ATPase subunit interface; other site 324057016243 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016244 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057016245 Response regulator receiver domain; Region: Response_reg; pfam00072 324057016246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057016247 active site 324057016248 phosphorylation site [posttranslational modification] 324057016249 intermolecular recognition site; other site 324057016250 dimerization interface [polypeptide binding]; other site 324057016251 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016252 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057016253 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016254 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057016255 Histidine kinase; Region: His_kinase; pfam06580 324057016256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057016257 ATP binding site [chemical binding]; other site 324057016258 Mg2+ binding site [ion binding]; other site 324057016259 G-X-G motif; other site 324057016260 cystathionine beta-lyase; Provisional; Region: PRK07671 324057016261 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 324057016262 homodimer interface [polypeptide binding]; other site 324057016263 substrate-cofactor binding pocket; other site 324057016264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057016265 catalytic residue [active] 324057016266 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 324057016267 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 324057016268 dimer interface [polypeptide binding]; other site 324057016269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057016270 catalytic residue [active] 324057016271 Methyltransferase domain; Region: Methyltransf_23; pfam13489 324057016272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057016273 S-adenosylmethionine binding site [chemical binding]; other site 324057016274 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 324057016275 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 324057016276 putative active site [active] 324057016277 catalytic site [active] 324057016278 putative metal binding site [ion binding]; other site 324057016279 Probable beta-xylosidase; Provisional; Region: PLN03080 324057016280 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 324057016281 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 324057016282 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 324057016283 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 324057016284 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057016285 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057016286 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 324057016287 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057016288 dockerin binding interface; other site 324057016289 S-layer homology domain; Region: SLH; pfam00395 324057016290 S-layer homology domain; Region: SLH; pfam00395 324057016291 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 324057016292 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 324057016293 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 324057016294 metal binding site [ion binding]; metal-binding site 324057016295 ligand binding site [chemical binding]; other site 324057016296 Putative Ig domain; Region: He_PIG; pfam05345 324057016297 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 324057016298 dockerin binding interface; other site 324057016299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057016300 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057016301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057016302 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057016303 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057016304 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 324057016305 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 324057016306 active site 324057016307 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 324057016308 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057016309 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 324057016310 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 324057016311 AsnC family; Region: AsnC_trans_reg; pfam01037 324057016312 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 324057016313 Cation efflux family; Region: Cation_efflux; pfam01545 324057016314 putative oxidoreductase; Provisional; Region: PRK11579 324057016315 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057016316 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057016317 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324057016318 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 324057016319 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 324057016320 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057016321 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057016322 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016323 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 324057016324 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 324057016325 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057016326 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 324057016327 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057016328 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 324057016329 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 324057016330 putative NAD(P) binding site [chemical binding]; other site 324057016331 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057016332 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057016333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016334 AAA domain; Region: AAA_17; pfam13207 324057016335 AAA domain; Region: AAA_18; pfam13238 324057016336 DinB family; Region: DinB; cl17821 324057016337 DinB superfamily; Region: DinB_2; pfam12867 324057016338 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324057016339 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324057016340 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 324057016341 Walker A/P-loop; other site 324057016342 ATP binding site [chemical binding]; other site 324057016343 Q-loop/lid; other site 324057016344 ABC transporter signature motif; other site 324057016345 Walker B; other site 324057016346 D-loop; other site 324057016347 H-loop/switch region; other site 324057016348 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 324057016349 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057016350 ABC-ATPase subunit interface; other site 324057016351 dimer interface [polypeptide binding]; other site 324057016352 putative PBP binding regions; other site 324057016353 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 324057016354 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 324057016355 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057016356 putative PBP binding regions; other site 324057016357 ABC-ATPase subunit interface; other site 324057016358 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 324057016359 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057016360 intersubunit interface [polypeptide binding]; other site 324057016361 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057016362 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057016363 intersubunit interface [polypeptide binding]; other site 324057016364 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324057016365 beta-D-glucuronidase; Provisional; Region: PRK10150 324057016366 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057016367 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 324057016368 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057016369 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057016370 Predicted transcriptional regulator [Transcription]; Region: COG2378 324057016371 HTH domain; Region: HTH_11; pfam08279 324057016372 WYL domain; Region: WYL; pfam13280 324057016373 EamA-like transporter family; Region: EamA; pfam00892 324057016374 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 324057016375 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 324057016376 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 324057016377 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 324057016378 active site 324057016379 intersubunit interface [polypeptide binding]; other site 324057016380 catalytic residue [active] 324057016381 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 324057016382 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 324057016383 minor groove reading motif; other site 324057016384 helix-hairpin-helix signature motif; other site 324057016385 substrate binding pocket [chemical binding]; other site 324057016386 active site 324057016387 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 324057016388 DNA binding and oxoG recognition site [nucleotide binding] 324057016389 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016390 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057016391 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016392 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 324057016393 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 324057016394 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 324057016395 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 324057016396 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 324057016397 homodimer interface [polypeptide binding]; other site 324057016398 NAD binding pocket [chemical binding]; other site 324057016399 ATP binding pocket [chemical binding]; other site 324057016400 Mg binding site [ion binding]; other site 324057016401 active-site loop [active] 324057016402 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 324057016403 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 324057016404 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 324057016405 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057016406 dimer interface [polypeptide binding]; other site 324057016407 phosphorylation site [posttranslational modification] 324057016408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057016409 ATP binding site [chemical binding]; other site 324057016410 Mg2+ binding site [ion binding]; other site 324057016411 G-X-G motif; other site 324057016412 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 324057016413 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 324057016414 TAP-like protein; Region: Abhydrolase_4; pfam08386 324057016415 HI0933-like protein; Region: HI0933_like; pfam03486 324057016416 PAS domain; Region: PAS_9; pfam13426 324057016417 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057016418 non-specific DNA binding site [nucleotide binding]; other site 324057016419 salt bridge; other site 324057016420 sequence-specific DNA binding site [nucleotide binding]; other site 324057016421 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 324057016422 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 324057016423 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324057016424 DNA binding residues [nucleotide binding] 324057016425 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 324057016426 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 324057016427 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 324057016428 homotrimer interaction site [polypeptide binding]; other site 324057016429 putative active site [active] 324057016430 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 324057016431 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 324057016432 N- and C-terminal domain interface [polypeptide binding]; other site 324057016433 D-xylulose kinase; Region: XylB; TIGR01312 324057016434 active site 324057016435 MgATP binding site [chemical binding]; other site 324057016436 catalytic site [active] 324057016437 metal binding site [ion binding]; metal-binding site 324057016438 xylulose binding site [chemical binding]; other site 324057016439 homodimer interface [polypeptide binding]; other site 324057016440 xylose isomerase; Provisional; Region: PRK05474 324057016441 xylose isomerase; Region: xylose_isom_A; TIGR02630 324057016442 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 324057016443 non-specific DNA binding site [nucleotide binding]; other site 324057016444 salt bridge; other site 324057016445 sequence-specific DNA binding site [nucleotide binding]; other site 324057016446 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 324057016447 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 324057016448 active site 324057016449 Haemolysin XhlA; Region: XhlA; pfam10779 324057016450 Phage-related tail fibre protein [General function prediction only]; Region: COG5301 324057016451 kelch-like protein; Provisional; Region: PHA03098 324057016452 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 324057016453 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 324057016454 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 324057016455 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 324057016456 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 324057016457 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 324057016458 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057016459 tape measure domain; Region: tape_meas_nterm; TIGR02675 324057016460 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 324057016461 Phage XkdN-like protein; Region: XkdN; pfam08890 324057016462 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 324057016463 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 324057016464 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 324057016465 ECF sigma factor; Region: Sigma70_ECF; pfam07638 324057016466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057016467 non-specific DNA binding site [nucleotide binding]; other site 324057016468 salt bridge; other site 324057016469 sequence-specific DNA binding site [nucleotide binding]; other site 324057016470 MarR family; Region: MarR_2; pfam12802 324057016471 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324057016472 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 324057016473 nucleotide binding site [chemical binding]; other site 324057016474 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 324057016475 S-layer homology domain; Region: SLH; pfam00395 324057016476 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 324057016477 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 324057016478 metal binding site [ion binding]; metal-binding site 324057016479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057016480 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057016481 putative substrate translocation pore; other site 324057016482 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 324057016483 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 324057016484 active site 324057016485 catalytic residues [active] 324057016486 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 324057016487 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 324057016488 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 324057016489 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 324057016490 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 324057016491 dimer interface [polypeptide binding]; other site 324057016492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057016493 catalytic residue [active] 324057016494 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 324057016495 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 324057016496 active site 324057016497 AMP binding site [chemical binding]; other site 324057016498 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 324057016499 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057016500 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 324057016501 Walker A/P-loop; other site 324057016502 ATP binding site [chemical binding]; other site 324057016503 Q-loop/lid; other site 324057016504 ABC transporter signature motif; other site 324057016505 Walker B; other site 324057016506 D-loop; other site 324057016507 H-loop/switch region; other site 324057016508 methionine sulfoxide reductase A; Provisional; Region: PRK14054 324057016509 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 324057016510 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 324057016511 putative NADP binding site [chemical binding]; other site 324057016512 putative dimer interface [polypeptide binding]; other site 324057016513 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 324057016514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057016515 S-adenosylmethionine binding site [chemical binding]; other site 324057016516 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057016517 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057016518 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324057016519 dimerization interface [polypeptide binding]; other site 324057016520 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 324057016521 glycogen binding site [chemical binding]; other site 324057016522 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 324057016523 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 324057016524 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 324057016525 maltodextrin glucosidase; Provisional; Region: PRK10785 324057016526 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 324057016527 active site 324057016528 homodimer interface [polypeptide binding]; other site 324057016529 catalytic site [active] 324057016530 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 324057016531 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057016532 Interdomain contacts; other site 324057016533 Cytokine receptor motif; other site 324057016534 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 324057016535 S-layer homology domain; Region: SLH; pfam00395 324057016536 S-layer homology domain; Region: SLH; pfam00395 324057016537 S-layer homology domain; Region: SLH; pfam00395 324057016538 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 324057016539 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 324057016540 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057016541 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016542 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057016543 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016544 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057016545 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057016546 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057016547 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057016548 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057016549 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057016550 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 324057016551 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 324057016552 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057016553 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016554 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057016555 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057016556 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016558 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 324057016559 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 324057016560 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 324057016561 putative substrate binding site [chemical binding]; other site 324057016562 putative ATP binding site [chemical binding]; other site 324057016563 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057016564 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057016565 DNA binding site [nucleotide binding] 324057016566 domain linker motif; other site 324057016567 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 324057016568 dimerization interface [polypeptide binding]; other site 324057016569 ligand binding site [chemical binding]; other site 324057016570 sodium binding site [ion binding]; other site 324057016571 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057016572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016573 dimer interface [polypeptide binding]; other site 324057016574 conserved gate region; other site 324057016575 ABC-ATPase subunit interface; other site 324057016576 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057016577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016578 dimer interface [polypeptide binding]; other site 324057016579 conserved gate region; other site 324057016580 putative PBP binding loops; other site 324057016581 ABC-ATPase subunit interface; other site 324057016582 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016583 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057016584 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 324057016585 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 324057016586 substrate binding [chemical binding]; other site 324057016587 active site 324057016588 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 324057016589 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 324057016590 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 324057016591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057016592 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057016593 putative substrate translocation pore; other site 324057016594 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 324057016595 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324057016596 Walker A/P-loop; other site 324057016597 ATP binding site [chemical binding]; other site 324057016598 Q-loop/lid; other site 324057016599 ABC transporter signature motif; other site 324057016600 Walker B; other site 324057016601 D-loop; other site 324057016602 H-loop/switch region; other site 324057016603 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 324057016604 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324057016605 Walker A/P-loop; other site 324057016606 ATP binding site [chemical binding]; other site 324057016607 Q-loop/lid; other site 324057016608 ABC transporter signature motif; other site 324057016609 Walker B; other site 324057016610 D-loop; other site 324057016611 H-loop/switch region; other site 324057016612 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 324057016613 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 324057016614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016615 dimer interface [polypeptide binding]; other site 324057016616 conserved gate region; other site 324057016617 ABC-ATPase subunit interface; other site 324057016618 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 324057016619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016620 dimer interface [polypeptide binding]; other site 324057016621 conserved gate region; other site 324057016622 putative PBP binding loops; other site 324057016623 ABC-ATPase subunit interface; other site 324057016624 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 324057016625 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 324057016626 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 324057016627 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 324057016628 active site 324057016629 non-prolyl cis peptide bond; other site 324057016630 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 324057016631 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 324057016632 metal binding site [ion binding]; metal-binding site 324057016633 dimer interface [polypeptide binding]; other site 324057016634 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 324057016635 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 324057016636 active site 324057016637 non-prolyl cis peptide bond; other site 324057016638 DinB superfamily; Region: DinB_2; pfam12867 324057016639 metal-dependent hydrolase; Provisional; Region: PRK13291 324057016640 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 324057016641 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 324057016642 metal binding site [ion binding]; metal-binding site 324057016643 dimer interface [polypeptide binding]; other site 324057016644 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 324057016645 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 324057016646 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 324057016647 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 324057016648 Walker A/P-loop; other site 324057016649 ATP binding site [chemical binding]; other site 324057016650 Q-loop/lid; other site 324057016651 ABC transporter signature motif; other site 324057016652 Walker B; other site 324057016653 D-loop; other site 324057016654 H-loop/switch region; other site 324057016655 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 324057016656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016657 dimer interface [polypeptide binding]; other site 324057016658 conserved gate region; other site 324057016659 putative PBP binding loops; other site 324057016660 ABC-ATPase subunit interface; other site 324057016661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016662 dimer interface [polypeptide binding]; other site 324057016663 conserved gate region; other site 324057016664 putative PBP binding loops; other site 324057016665 ABC-ATPase subunit interface; other site 324057016666 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 324057016667 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324057016668 substrate binding pocket [chemical binding]; other site 324057016669 membrane-bound complex binding site; other site 324057016670 hinge residues; other site 324057016671 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324057016672 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057016673 Coenzyme A binding pocket [chemical binding]; other site 324057016674 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057016675 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057016676 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057016677 dimerization interface [polypeptide binding]; other site 324057016678 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 324057016679 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 324057016680 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 324057016681 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 324057016682 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016683 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057016684 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057016685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016686 dimer interface [polypeptide binding]; other site 324057016687 conserved gate region; other site 324057016688 putative PBP binding loops; other site 324057016689 ABC-ATPase subunit interface; other site 324057016690 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057016691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016692 dimer interface [polypeptide binding]; other site 324057016693 conserved gate region; other site 324057016694 putative PBP binding loops; other site 324057016695 ABC-ATPase subunit interface; other site 324057016696 Response regulator receiver domain; Region: Response_reg; pfam00072 324057016697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057016698 active site 324057016699 phosphorylation site [posttranslational modification] 324057016700 intermolecular recognition site; other site 324057016701 dimerization interface [polypeptide binding]; other site 324057016702 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016703 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057016704 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016705 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057016706 dimerization interface [polypeptide binding]; other site 324057016707 Histidine kinase; Region: His_kinase; pfam06580 324057016708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057016709 ATP binding site [chemical binding]; other site 324057016710 Mg2+ binding site [ion binding]; other site 324057016711 G-X-G motif; other site 324057016712 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 324057016713 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 324057016714 active site 324057016715 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057016716 sugar binding site [chemical binding]; other site 324057016717 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 324057016718 active site 324057016719 multimer interface [polypeptide binding]; other site 324057016720 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057016721 PAS domain; Region: PAS_9; pfam13426 324057016722 putative active site [active] 324057016723 heme pocket [chemical binding]; other site 324057016724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324057016725 Histidine kinase; Region: HisKA_3; pfam07730 324057016726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057016727 ATP binding site [chemical binding]; other site 324057016728 Mg2+ binding site [ion binding]; other site 324057016729 G-X-G motif; other site 324057016730 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057016731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057016732 active site 324057016733 phosphorylation site [posttranslational modification] 324057016734 intermolecular recognition site; other site 324057016735 dimerization interface [polypeptide binding]; other site 324057016736 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057016737 DNA binding residues [nucleotide binding] 324057016738 dimerization interface [polypeptide binding]; other site 324057016739 GAF domain; Region: GAF; cl17456 324057016740 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 324057016741 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324057016742 ligand binding site [chemical binding]; other site 324057016743 flexible hinge region; other site 324057016744 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 324057016745 putative switch regulator; other site 324057016746 non-specific DNA interactions [nucleotide binding]; other site 324057016747 DNA binding site [nucleotide binding] 324057016748 sequence specific DNA binding site [nucleotide binding]; other site 324057016749 putative cAMP binding site [chemical binding]; other site 324057016750 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 324057016751 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057016752 FeS/SAM binding site; other site 324057016753 Pyruvate formate lyase 1; Region: PFL1; cd01678 324057016754 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 324057016755 coenzyme A binding site [chemical binding]; other site 324057016756 active site 324057016757 catalytic residues [active] 324057016758 glycine loop; other site 324057016759 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 324057016760 GTP binding site; other site 324057016761 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 324057016762 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 324057016763 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057016764 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016765 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016766 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057016767 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057016768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057016769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016770 ABC-ATPase subunit interface; other site 324057016771 putative PBP binding loops; other site 324057016772 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057016773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016774 dimer interface [polypeptide binding]; other site 324057016775 conserved gate region; other site 324057016776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057016777 ABC-ATPase subunit interface; other site 324057016778 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 324057016779 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 324057016780 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057016781 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057016782 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 324057016783 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 324057016784 active site 324057016785 catalytic triad [active] 324057016786 oxyanion hole [active] 324057016787 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057016788 Radical SAM superfamily; Region: Radical_SAM; pfam04055 324057016789 FeS/SAM binding site; other site 324057016790 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057016791 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 324057016792 putative active site [active] 324057016793 heme pocket [chemical binding]; other site 324057016794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057016795 dimer interface [polypeptide binding]; other site 324057016796 phosphorylation site [posttranslational modification] 324057016797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057016798 ATP binding site [chemical binding]; other site 324057016799 Mg2+ binding site [ion binding]; other site 324057016800 G-X-G motif; other site 324057016801 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057016802 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 324057016803 Metal-binding active site; metal-binding site 324057016804 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057016805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057016806 active site 324057016807 phosphorylation site [posttranslational modification] 324057016808 intermolecular recognition site; other site 324057016809 dimerization interface [polypeptide binding]; other site 324057016810 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016811 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057016812 HAMP domain; Region: HAMP; pfam00672 324057016813 Histidine kinase; Region: His_kinase; pfam06580 324057016814 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 324057016815 ATP binding site [chemical binding]; other site 324057016816 Mg2+ binding site [ion binding]; other site 324057016817 G-X-G motif; other site 324057016818 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057016819 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016820 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057016821 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 324057016822 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 324057016823 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 324057016824 S-layer homology domain; Region: SLH; pfam00395 324057016825 S-layer homology domain; Region: SLH; pfam00395 324057016826 S-layer homology domain; Region: SLH; pfam00395 324057016827 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057016828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016829 dimer interface [polypeptide binding]; other site 324057016830 conserved gate region; other site 324057016831 putative PBP binding loops; other site 324057016832 ABC-ATPase subunit interface; other site 324057016833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016834 dimer interface [polypeptide binding]; other site 324057016835 conserved gate region; other site 324057016836 putative PBP binding loops; other site 324057016837 ABC-ATPase subunit interface; other site 324057016838 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016839 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057016840 KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592 324057016841 putative active site [active] 324057016842 putative catalytic site [active] 324057016843 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057016844 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057016845 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057016846 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 324057016847 Ca binding site [ion binding]; other site 324057016848 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057016849 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057016850 DNA binding site [nucleotide binding] 324057016851 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057016852 dimerization interface [polypeptide binding]; other site 324057016853 ligand binding site [chemical binding]; other site 324057016854 DoxX; Region: DoxX; cl17842 324057016855 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 324057016856 DinB family; Region: DinB; cl17821 324057016857 DinB superfamily; Region: DinB_2; pfam12867 324057016858 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 324057016859 RDD family; Region: RDD; pfam06271 324057016860 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 324057016861 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 324057016862 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 324057016863 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 324057016864 metal ion-dependent adhesion site (MIDAS); other site 324057016865 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 324057016866 nudix motif; other site 324057016867 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 324057016868 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 324057016869 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 324057016870 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 324057016871 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057016872 Walker A/P-loop; other site 324057016873 ATP binding site [chemical binding]; other site 324057016874 Q-loop/lid; other site 324057016875 ABC transporter signature motif; other site 324057016876 Walker B; other site 324057016877 D-loop; other site 324057016878 H-loop/switch region; other site 324057016879 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 324057016880 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 324057016881 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057016882 Walker A/P-loop; other site 324057016883 ATP binding site [chemical binding]; other site 324057016884 Q-loop/lid; other site 324057016885 ABC transporter signature motif; other site 324057016886 Walker B; other site 324057016887 D-loop; other site 324057016888 H-loop/switch region; other site 324057016889 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057016890 DNA-binding site [nucleotide binding]; DNA binding site 324057016891 Protein of unknown function (DUF420); Region: DUF420; pfam04238 324057016892 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 324057016893 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 324057016894 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 324057016895 Subunit I/III interface [polypeptide binding]; other site 324057016896 Subunit III/IV interface [polypeptide binding]; other site 324057016897 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 324057016898 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 324057016899 D-pathway; other site 324057016900 Putative ubiquinol binding site [chemical binding]; other site 324057016901 Low-spin heme (heme b) binding site [chemical binding]; other site 324057016902 Putative water exit pathway; other site 324057016903 Binuclear center (heme o3/CuB) [ion binding]; other site 324057016904 K-pathway; other site 324057016905 Putative proton exit pathway; other site 324057016906 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 324057016907 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 324057016908 Cytochrome c; Region: Cytochrom_C; pfam00034 324057016909 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 324057016910 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 324057016911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057016912 sugar efflux transporter; Region: 2A0120; TIGR00899 324057016913 putative substrate translocation pore; other site 324057016914 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057016915 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057016916 active site 324057016917 catalytic tetrad [active] 324057016918 Predicted transcriptional regulators [Transcription]; Region: COG1733 324057016919 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 324057016920 Spore germination protein; Region: Spore_permease; cl17796 324057016921 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057016922 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057016923 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057016924 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057016925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016926 dimer interface [polypeptide binding]; other site 324057016927 conserved gate region; other site 324057016928 ABC-ATPase subunit interface; other site 324057016929 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057016930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057016931 dimer interface [polypeptide binding]; other site 324057016932 conserved gate region; other site 324057016933 putative PBP binding loops; other site 324057016934 ABC-ATPase subunit interface; other site 324057016935 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057016936 Response regulator receiver domain; Region: Response_reg; pfam00072 324057016937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057016938 active site 324057016939 phosphorylation site [posttranslational modification] 324057016940 intermolecular recognition site; other site 324057016941 dimerization interface [polypeptide binding]; other site 324057016942 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016943 Helix-turn-helix domain; Region: HTH_18; pfam12833 324057016944 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057016945 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057016946 dimerization interface [polypeptide binding]; other site 324057016947 Histidine kinase; Region: His_kinase; pfam06580 324057016948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057016949 ATP binding site [chemical binding]; other site 324057016950 Mg2+ binding site [ion binding]; other site 324057016951 G-X-G motif; other site 324057016952 Response regulator receiver domain; Region: Response_reg; pfam00072 324057016953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057016954 active site 324057016955 phosphorylation site [posttranslational modification] 324057016956 intermolecular recognition site; other site 324057016957 dimerization interface [polypeptide binding]; other site 324057016958 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057016959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016960 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057016961 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057016962 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057016963 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 324057016964 dimerization interface [polypeptide binding]; other site 324057016965 active site 324057016966 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 324057016967 metal-binding site [ion binding] 324057016968 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 324057016969 putative homodimer interface [polypeptide binding]; other site 324057016970 putative homotetramer interface [polypeptide binding]; other site 324057016971 allosteric switch controlling residues; other site 324057016972 putative metal binding site [ion binding]; other site 324057016973 putative homodimer-homodimer interface [polypeptide binding]; other site 324057016974 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 324057016975 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 324057016976 active site 324057016977 catalytic site [active] 324057016978 metal binding site [ion binding]; metal-binding site 324057016979 dimer interface [polypeptide binding]; other site 324057016980 Uncharacterized conserved protein [Function unknown]; Region: COG1284 324057016981 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324057016982 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324057016983 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 324057016984 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 324057016985 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057016986 putative ligand binding site [chemical binding]; other site 324057016987 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 324057016988 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 324057016989 TM-ABC transporter signature motif; other site 324057016990 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 324057016991 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 324057016992 Walker A/P-loop; other site 324057016993 ATP binding site [chemical binding]; other site 324057016994 Q-loop/lid; other site 324057016995 ABC transporter signature motif; other site 324057016996 Walker B; other site 324057016997 D-loop; other site 324057016998 H-loop/switch region; other site 324057016999 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 324057017000 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 324057017001 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324057017002 putative ligand binding site [chemical binding]; other site 324057017003 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057017004 Cache domain; Region: Cache_1; pfam02743 324057017005 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057017006 dimerization interface [polypeptide binding]; other site 324057017007 Histidine kinase; Region: His_kinase; pfam06580 324057017008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057017009 ATP binding site [chemical binding]; other site 324057017010 Mg2+ binding site [ion binding]; other site 324057017011 G-X-G motif; other site 324057017012 Response regulator receiver domain; Region: Response_reg; pfam00072 324057017013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057017014 active site 324057017015 phosphorylation site [posttranslational modification] 324057017016 intermolecular recognition site; other site 324057017017 dimerization interface [polypeptide binding]; other site 324057017018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017019 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057017020 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017021 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 324057017022 Predicted permeases [General function prediction only]; Region: COG0679 324057017023 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 324057017024 glycerol kinase; Provisional; Region: glpK; PRK00047 324057017025 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 324057017026 N- and C-terminal domain interface [polypeptide binding]; other site 324057017027 active site 324057017028 MgATP binding site [chemical binding]; other site 324057017029 catalytic site [active] 324057017030 metal binding site [ion binding]; metal-binding site 324057017031 glycerol binding site [chemical binding]; other site 324057017032 homotetramer interface [polypeptide binding]; other site 324057017033 homodimer interface [polypeptide binding]; other site 324057017034 FBP binding site [chemical binding]; other site 324057017035 protein IIAGlc interface [polypeptide binding]; other site 324057017036 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 324057017037 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 324057017038 Glutamate binding site [chemical binding]; other site 324057017039 homodimer interface [polypeptide binding]; other site 324057017040 NAD binding site [chemical binding]; other site 324057017041 catalytic residues [active] 324057017042 Proline dehydrogenase; Region: Pro_dh; cl03282 324057017043 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 324057017044 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 324057017045 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 324057017046 active site 324057017047 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 324057017048 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 324057017049 DinB family; Region: DinB; cl17821 324057017050 DinB superfamily; Region: DinB_2; pfam12867 324057017051 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 324057017052 Predicted membrane protein [Function unknown]; Region: COG3766 324057017053 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 324057017054 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 324057017055 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057017056 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057017057 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057017058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017059 dimer interface [polypeptide binding]; other site 324057017060 conserved gate region; other site 324057017061 ABC-ATPase subunit interface; other site 324057017062 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057017063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017064 dimer interface [polypeptide binding]; other site 324057017065 conserved gate region; other site 324057017066 ABC-ATPase subunit interface; other site 324057017067 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 324057017068 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 324057017069 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324057017070 NAD binding site [chemical binding]; other site 324057017071 dimer interface [polypeptide binding]; other site 324057017072 substrate binding site [chemical binding]; other site 324057017073 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 324057017074 catalytic residues [active] 324057017075 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 324057017076 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 324057017077 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 324057017078 active site 324057017079 HIGH motif; other site 324057017080 KMSK motif region; other site 324057017081 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 324057017082 tRNA binding surface [nucleotide binding]; other site 324057017083 anticodon binding site; other site 324057017084 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 324057017085 nudix motif; other site 324057017086 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 324057017087 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 324057017088 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 324057017089 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 324057017090 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057017091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057017092 NAD(P) binding site [chemical binding]; other site 324057017093 active site 324057017094 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 324057017095 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 324057017096 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 324057017097 minor groove reading motif; other site 324057017098 helix-hairpin-helix signature motif; other site 324057017099 substrate binding pocket [chemical binding]; other site 324057017100 active site 324057017101 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 324057017102 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 324057017103 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017104 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017105 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 324057017106 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 324057017107 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 324057017108 DNA binding site [nucleotide binding] 324057017109 active site 324057017110 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 324057017111 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 324057017112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057017113 catalytic residue [active] 324057017114 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 324057017115 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 324057017116 active site 324057017117 homodimer interface [polypeptide binding]; other site 324057017118 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057017119 dimerization interface [polypeptide binding]; other site 324057017120 putative DNA binding site [nucleotide binding]; other site 324057017121 putative Zn2+ binding site [ion binding]; other site 324057017122 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 324057017123 putative hydrophobic ligand binding site [chemical binding]; other site 324057017124 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 324057017125 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 324057017126 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 324057017127 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057017128 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057017129 DNA binding residues [nucleotide binding] 324057017130 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 324057017131 Protein of unknown function DUF72; Region: DUF72; pfam01904 324057017132 hypothetical protein; Validated; Region: PRK07682 324057017133 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057017134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057017135 homodimer interface [polypeptide binding]; other site 324057017136 catalytic residue [active] 324057017137 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 324057017138 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 324057017139 ATP-grasp domain; Region: ATP-grasp_4; cl17255 324057017140 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 324057017141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057017142 DNA-binding site [nucleotide binding]; DNA binding site 324057017143 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057017144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057017145 homodimer interface [polypeptide binding]; other site 324057017146 catalytic residue [active] 324057017147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057017148 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 324057017149 NAD(P) binding site [chemical binding]; other site 324057017150 active site 324057017151 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057017152 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057017153 S-layer homology domain; Region: SLH; pfam00395 324057017154 S-layer homology domain; Region: SLH; pfam00395 324057017155 S-layer homology domain; Region: SLH; pfam00395 324057017156 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 324057017157 active site 324057017158 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 324057017159 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 324057017160 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 324057017161 NodB motif; other site 324057017162 active site 324057017163 catalytic site [active] 324057017164 metal binding site [ion binding]; metal-binding site 324057017165 MEKHLA domain; Region: MEKHLA; pfam08670 324057017166 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 324057017167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324057017168 motif II; other site 324057017169 Domain of unknown function (DUF336); Region: DUF336; cl01249 324057017170 Predicted transcriptional regulators [Transcription]; Region: COG1733 324057017171 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 324057017172 short chain dehydrogenase; Provisional; Region: PRK07041 324057017173 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057017174 NAD(P) binding site [chemical binding]; other site 324057017175 active site 324057017176 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 324057017177 substrate binding pocket [chemical binding]; other site 324057017178 substrate-Mg2+ binding site; other site 324057017179 aspartate-rich region 1; other site 324057017180 aspartate-rich region 2; other site 324057017181 Predicted transcriptional regulator [Transcription]; Region: COG2345 324057017182 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 324057017183 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 324057017184 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 324057017185 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 324057017186 putative active site [active] 324057017187 putative metal binding site [ion binding]; other site 324057017188 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 324057017189 NlpC/P60 family; Region: NLPC_P60; pfam00877 324057017190 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 324057017191 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 324057017192 substrate binding pocket [chemical binding]; other site 324057017193 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 324057017194 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 324057017195 dimer interface [polypeptide binding]; other site 324057017196 substrate binding site [chemical binding]; other site 324057017197 ATP binding site [chemical binding]; other site 324057017198 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 324057017199 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 324057017200 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 324057017201 ThiS interaction site; other site 324057017202 putative active site [active] 324057017203 tetramer interface [polypeptide binding]; other site 324057017204 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 324057017205 thiS-thiF/thiG interaction site; other site 324057017206 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 324057017207 thiamine phosphate binding site [chemical binding]; other site 324057017208 active site 324057017209 pyrophosphate binding site [ion binding]; other site 324057017210 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 324057017211 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 324057017212 ATP binding site [chemical binding]; other site 324057017213 substrate interface [chemical binding]; other site 324057017214 NMT1/THI5 like; Region: NMT1; pfam09084 324057017215 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 324057017216 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057017217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017218 dimer interface [polypeptide binding]; other site 324057017219 conserved gate region; other site 324057017220 ABC-ATPase subunit interface; other site 324057017221 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324057017222 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 324057017223 Walker A/P-loop; other site 324057017224 ATP binding site [chemical binding]; other site 324057017225 Q-loop/lid; other site 324057017226 ABC transporter signature motif; other site 324057017227 Walker B; other site 324057017228 D-loop; other site 324057017229 H-loop/switch region; other site 324057017230 Putative transcription activator [Transcription]; Region: TenA; COG0819 324057017231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057017232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057017233 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324057017234 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 324057017235 Walker A/P-loop; other site 324057017236 ATP binding site [chemical binding]; other site 324057017237 Q-loop/lid; other site 324057017238 ABC transporter signature motif; other site 324057017239 Walker B; other site 324057017240 D-loop; other site 324057017241 H-loop/switch region; other site 324057017242 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 324057017243 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 324057017244 active site 324057017245 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 324057017246 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057017247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017248 dimer interface [polypeptide binding]; other site 324057017249 conserved gate region; other site 324057017250 putative PBP binding loops; other site 324057017251 ABC-ATPase subunit interface; other site 324057017252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057017253 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 324057017254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017255 ABC-ATPase subunit interface; other site 324057017256 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057017257 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057017258 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057017259 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057017260 DNA binding site [nucleotide binding] 324057017261 domain linker motif; other site 324057017262 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 324057017263 putative dimerization interface [polypeptide binding]; other site 324057017264 putative ligand binding site [chemical binding]; other site 324057017265 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 324057017266 putative active site; other site 324057017267 putative metal binding residues [ion binding]; other site 324057017268 signature motif; other site 324057017269 putative triphosphate binding site [ion binding]; other site 324057017270 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 324057017271 Protein of unknown function (DUF779); Region: DUF779; pfam05610 324057017272 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 324057017273 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 324057017274 NAD(P) binding site [chemical binding]; other site 324057017275 catalytic residues [active] 324057017276 heat shock protein 90; Provisional; Region: PRK05218 324057017277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057017278 ATP binding site [chemical binding]; other site 324057017279 Mg2+ binding site [ion binding]; other site 324057017280 G-X-G motif; other site 324057017281 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 324057017282 Beta-lactamase; Region: Beta-lactamase; pfam00144 324057017283 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 324057017284 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 324057017285 tetramer interface [polypeptide binding]; other site 324057017286 heme binding pocket [chemical binding]; other site 324057017287 NADPH binding site [chemical binding]; other site 324057017288 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 324057017289 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 324057017290 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 324057017291 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 324057017292 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057017293 Zn binding site [ion binding]; other site 324057017294 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 324057017295 Zn binding site [ion binding]; other site 324057017296 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 324057017297 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 324057017298 dimerization interface [polypeptide binding]; other site 324057017299 DPS ferroxidase diiron center [ion binding]; other site 324057017300 ion pore; other site 324057017301 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 324057017302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057017303 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057017304 putative substrate translocation pore; other site 324057017305 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 324057017306 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 324057017307 active site 324057017308 Isochorismatase family; Region: Isochorismatase; pfam00857 324057017309 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 324057017310 catalytic triad [active] 324057017311 dimer interface [polypeptide binding]; other site 324057017312 conserved cis-peptide bond; other site 324057017313 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 324057017314 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 324057017315 nucleophilic elbow; other site 324057017316 catalytic triad; other site 324057017317 TAP-like protein; Region: Abhydrolase_4; pfam08386 324057017318 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 324057017319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057017320 active site 324057017321 phosphorylation site [posttranslational modification] 324057017322 intermolecular recognition site; other site 324057017323 dimerization interface [polypeptide binding]; other site 324057017324 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017325 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057017326 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057017327 dimerization interface [polypeptide binding]; other site 324057017328 Histidine kinase; Region: His_kinase; pfam06580 324057017329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057017330 ATP binding site [chemical binding]; other site 324057017331 Mg2+ binding site [ion binding]; other site 324057017332 G-X-G motif; other site 324057017333 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057017334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057017335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057017336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057017337 dimerization interface [polypeptide binding]; other site 324057017338 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057017339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057017340 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057017341 dimerization interface [polypeptide binding]; other site 324057017342 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 324057017343 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 324057017344 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057017345 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057017346 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017347 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017348 Cupin domain; Region: Cupin_2; pfam07883 324057017349 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 324057017350 active site 324057017351 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 324057017352 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057017353 putative ADP-binding pocket [chemical binding]; other site 324057017354 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 324057017355 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 324057017356 substrate binding site; other site 324057017357 metal-binding site 324057017358 Oligomer interface; other site 324057017359 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 324057017360 putative trimer interface [polypeptide binding]; other site 324057017361 putative CoA binding site [chemical binding]; other site 324057017362 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 324057017363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057017364 S-adenosylmethionine binding site [chemical binding]; other site 324057017365 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 324057017366 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 324057017367 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 324057017368 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324057017369 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 324057017370 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057017371 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 324057017372 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057017373 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017374 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057017375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017376 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057017377 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 324057017378 active site 324057017379 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 324057017380 Melibiase; Region: Melibiase; pfam02065 324057017381 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057017382 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057017383 DNA binding site [nucleotide binding] 324057017384 domain linker motif; other site 324057017385 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 324057017386 putative dimerization interface [polypeptide binding]; other site 324057017387 putative ligand binding site [chemical binding]; other site 324057017388 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057017389 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 324057017390 Walker A/P-loop; other site 324057017391 ATP binding site [chemical binding]; other site 324057017392 Q-loop/lid; other site 324057017393 ABC transporter signature motif; other site 324057017394 Walker B; other site 324057017395 D-loop; other site 324057017396 H-loop/switch region; other site 324057017397 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 324057017398 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 324057017399 FtsX-like permease family; Region: FtsX; pfam02687 324057017400 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 324057017401 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057017402 dimerization interface [polypeptide binding]; other site 324057017403 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057017404 dimer interface [polypeptide binding]; other site 324057017405 phosphorylation site [posttranslational modification] 324057017406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057017407 ATP binding site [chemical binding]; other site 324057017408 Mg2+ binding site [ion binding]; other site 324057017409 G-X-G motif; other site 324057017410 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057017411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057017412 active site 324057017413 phosphorylation site [posttranslational modification] 324057017414 intermolecular recognition site; other site 324057017415 dimerization interface [polypeptide binding]; other site 324057017416 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057017417 DNA binding site [nucleotide binding] 324057017418 Ferredoxin [Energy production and conversion]; Region: COG1146 324057017419 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 324057017420 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 324057017421 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324057017422 NMT1/THI5 like; Region: NMT1; pfam09084 324057017423 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324057017424 substrate binding pocket [chemical binding]; other site 324057017425 membrane-bound complex binding site; other site 324057017426 Ferredoxin [Energy production and conversion]; Region: COG1146 324057017427 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 324057017428 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 324057017429 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 324057017430 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 324057017431 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057017432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017433 dimer interface [polypeptide binding]; other site 324057017434 conserved gate region; other site 324057017435 putative PBP binding loops; other site 324057017436 ABC-ATPase subunit interface; other site 324057017437 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057017438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017439 dimer interface [polypeptide binding]; other site 324057017440 conserved gate region; other site 324057017441 putative PBP binding loops; other site 324057017442 ABC-ATPase subunit interface; other site 324057017443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057017444 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 324057017445 putative substrate translocation pore; other site 324057017446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057017447 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057017448 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057017449 Predicted integral membrane protein [Function unknown]; Region: COG5658 324057017450 SdpI/YhfL protein family; Region: SdpI; pfam13630 324057017451 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057017452 dimerization interface [polypeptide binding]; other site 324057017453 putative DNA binding site [nucleotide binding]; other site 324057017454 putative Zn2+ binding site [ion binding]; other site 324057017455 tetracycline repressor protein TetR; Provisional; Region: PRK13756 324057017456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057017457 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 324057017458 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 324057017459 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 324057017460 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 324057017461 ABC-2 type transporter; Region: ABC2_membrane; cl17235 324057017462 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 324057017463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057017464 Walker A/P-loop; other site 324057017465 ATP binding site [chemical binding]; other site 324057017466 Q-loop/lid; other site 324057017467 ABC transporter signature motif; other site 324057017468 Walker B; other site 324057017469 D-loop; other site 324057017470 H-loop/switch region; other site 324057017471 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 324057017472 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057017473 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057017474 Predicted transcriptional regulators [Transcription]; Region: COG1695 324057017475 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 324057017476 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 324057017477 galactokinase; Provisional; Region: PRK00555 324057017478 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 324057017479 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057017480 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 324057017481 active site 324057017482 metal binding site [ion binding]; metal-binding site 324057017483 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057017484 DinB superfamily; Region: DinB_2; pfam12867 324057017485 methionine sulfoxide reductase A; Provisional; Region: PRK14054 324057017486 methionine sulfoxide reductase B; Provisional; Region: PRK00222 324057017487 SelR domain; Region: SelR; pfam01641 324057017488 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057017489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057017490 active site 324057017491 phosphorylation site [posttranslational modification] 324057017492 intermolecular recognition site; other site 324057017493 dimerization interface [polypeptide binding]; other site 324057017494 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057017495 DNA binding residues [nucleotide binding] 324057017496 dimerization interface [polypeptide binding]; other site 324057017497 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324057017498 Histidine kinase; Region: HisKA_3; pfam07730 324057017499 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 324057017500 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057017501 sugar binding site [chemical binding]; other site 324057017502 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057017503 sugar binding site [chemical binding]; other site 324057017504 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 324057017505 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057017506 sugar binding site [chemical binding]; other site 324057017507 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324057017508 sugar binding site [chemical binding]; other site 324057017509 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 324057017510 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 324057017511 Ligand binding site; other site 324057017512 Putative Catalytic site; other site 324057017513 DXD motif; other site 324057017514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057017515 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057017516 NAD(P) binding site [chemical binding]; other site 324057017517 active site 324057017518 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 324057017519 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 324057017520 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 324057017521 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 324057017522 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057017523 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 324057017524 MarR family; Region: MarR_2; cl17246 324057017525 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 324057017526 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324057017527 catalytic core [active] 324057017528 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 324057017529 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324057017530 ligand binding site [chemical binding]; other site 324057017531 flexible hinge region; other site 324057017532 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 324057017533 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 324057017534 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 324057017535 heme-binding site [chemical binding]; other site 324057017536 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 324057017537 FAD binding pocket [chemical binding]; other site 324057017538 FAD binding motif [chemical binding]; other site 324057017539 phosphate binding motif [ion binding]; other site 324057017540 beta-alpha-beta structure motif; other site 324057017541 NAD binding pocket [chemical binding]; other site 324057017542 Heme binding pocket [chemical binding]; other site 324057017543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057017544 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 324057017545 Walker A motif; other site 324057017546 ATP binding site [chemical binding]; other site 324057017547 Walker B motif; other site 324057017548 arginine finger; other site 324057017549 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 324057017550 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 324057017551 metal ion-dependent adhesion site (MIDAS); other site 324057017552 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324057017553 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057017554 Coenzyme A binding pocket [chemical binding]; other site 324057017555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 324057017556 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 324057017557 Uncharacterized conserved protein [Function unknown]; Region: COG0327 324057017558 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 324057017559 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 324057017560 Ligand Binding Site [chemical binding]; other site 324057017561 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 324057017562 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057017563 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057017564 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057017565 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057017566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017567 dimer interface [polypeptide binding]; other site 324057017568 ABC-ATPase subunit interface; other site 324057017569 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057017570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017571 dimer interface [polypeptide binding]; other site 324057017572 conserved gate region; other site 324057017573 ABC-ATPase subunit interface; other site 324057017574 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 324057017575 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324057017576 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057017577 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057017578 DNA binding site [nucleotide binding] 324057017579 domain linker motif; other site 324057017580 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057017581 dimerization interface [polypeptide binding]; other site 324057017582 ligand binding site [chemical binding]; other site 324057017583 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 324057017584 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 324057017585 homodimer interface [polypeptide binding]; other site 324057017586 NAD binding pocket [chemical binding]; other site 324057017587 ATP binding pocket [chemical binding]; other site 324057017588 Mg binding site [ion binding]; other site 324057017589 active-site loop [active] 324057017590 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 324057017591 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 324057017592 active site 324057017593 (T/H)XGH motif; other site 324057017594 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 324057017595 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 324057017596 active site 324057017597 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 324057017598 catalytic triad [active] 324057017599 conserved cis-peptide bond; other site 324057017600 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 324057017601 nudix motif; other site 324057017602 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 324057017603 Spore germination protein; Region: Spore_permease; cl17796 324057017604 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057017605 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057017606 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057017607 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057017608 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 324057017609 YCII-related domain; Region: YCII; cl00999 324057017610 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 324057017611 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057017612 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 324057017613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 324057017614 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324057017615 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 324057017616 putative deacylase active site [active] 324057017617 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057017618 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057017619 Response regulator receiver domain; Region: Response_reg; pfam00072 324057017620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057017621 active site 324057017622 phosphorylation site [posttranslational modification] 324057017623 intermolecular recognition site; other site 324057017624 dimerization interface [polypeptide binding]; other site 324057017625 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057017626 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017627 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017628 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057017629 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057017630 Histidine kinase; Region: His_kinase; pfam06580 324057017631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057017632 ATP binding site [chemical binding]; other site 324057017633 Mg2+ binding site [ion binding]; other site 324057017634 G-X-G motif; other site 324057017635 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057017636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017637 dimer interface [polypeptide binding]; other site 324057017638 conserved gate region; other site 324057017639 putative PBP binding loops; other site 324057017640 ABC-ATPase subunit interface; other site 324057017641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017642 dimer interface [polypeptide binding]; other site 324057017643 conserved gate region; other site 324057017644 putative PBP binding loops; other site 324057017645 ABC-ATPase subunit interface; other site 324057017646 Right handed beta helix region; Region: Beta_helix; pfam13229 324057017647 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 324057017648 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 324057017649 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 324057017650 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 324057017651 S-layer homology domain; Region: SLH; pfam00395 324057017652 S-layer homology domain; Region: SLH; pfam00395 324057017653 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057017654 Interdomain contacts; other site 324057017655 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 324057017656 putative metal binding site [ion binding]; other site 324057017657 potential frameshift: common BLAST hit: gi|150392276|ref|YP_001322325.1| membrane protein 324057017658 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 324057017659 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 324057017660 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 324057017661 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 324057017662 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 324057017663 active site 324057017664 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 324057017665 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057017666 Interdomain contacts; other site 324057017667 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 324057017668 Cytokine receptor motif; other site 324057017669 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 324057017670 active site 324057017671 catalytic triad [active] 324057017672 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057017673 Interdomain contacts; other site 324057017674 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 324057017675 Cytokine receptor motif; other site 324057017676 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057017677 Cytokine receptor motif; other site 324057017678 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057017679 Interdomain contacts; other site 324057017680 Cytokine receptor motif; other site 324057017681 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 324057017682 metal binding site [ion binding]; metal-binding site 324057017683 active site 324057017684 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 324057017685 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 324057017686 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057017687 dimerization interface [polypeptide binding]; other site 324057017688 putative DNA binding site [nucleotide binding]; other site 324057017689 putative Zn2+ binding site [ion binding]; other site 324057017690 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 324057017691 hydrophobic ligand binding site; other site 324057017692 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 324057017693 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 324057017694 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057017695 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 324057017696 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 324057017697 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057017698 salt bridge; other site 324057017699 non-specific DNA binding site [nucleotide binding]; other site 324057017700 sequence-specific DNA binding site [nucleotide binding]; other site 324057017701 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 324057017702 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 324057017703 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 324057017704 NAD(P) binding site [chemical binding]; other site 324057017705 catalytic residues [active] 324057017706 Helix-turn-helix domain; Region: HTH_18; pfam12833 324057017707 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017708 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 324057017709 putative hydrophobic ligand binding site [chemical binding]; other site 324057017710 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 324057017711 putative ligand binding site [chemical binding]; other site 324057017712 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057017713 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057017714 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057017715 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 324057017716 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057017717 Metal-binding active site; metal-binding site 324057017718 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057017719 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057017720 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017721 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324057017722 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324057017723 DNA binding site [nucleotide binding] 324057017724 domain linker motif; other site 324057017725 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324057017726 ligand binding site [chemical binding]; other site 324057017727 dimerization interface [polypeptide binding]; other site 324057017728 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057017729 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057017730 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057017731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017732 dimer interface [polypeptide binding]; other site 324057017733 conserved gate region; other site 324057017734 putative PBP binding loops; other site 324057017735 ABC-ATPase subunit interface; other site 324057017736 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057017737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017738 dimer interface [polypeptide binding]; other site 324057017739 putative PBP binding loops; other site 324057017740 ABC-ATPase subunit interface; other site 324057017741 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057017742 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057017743 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057017744 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 324057017745 S-layer homology domain; Region: SLH; pfam00395 324057017746 S-layer homology domain; Region: SLH; pfam00395 324057017747 S-layer homology domain; Region: SLH; pfam00395 324057017748 TM1410 hypothetical-related protein; Region: DUF297; cl00997 324057017749 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057017750 Interdomain contacts; other site 324057017751 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057017752 Interdomain contacts; other site 324057017753 Cytokine receptor motif; other site 324057017754 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 324057017755 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 324057017756 acyl-activating enzyme (AAE) consensus motif; other site 324057017757 AMP binding site [chemical binding]; other site 324057017758 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 324057017759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057017760 thioester reductase domain; Region: Thioester-redct; TIGR01746 324057017761 NAD(P) binding site [chemical binding]; other site 324057017762 active site 324057017763 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 324057017764 dimerization interface [polypeptide binding]; other site 324057017765 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057017766 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057017767 dimer interface [polypeptide binding]; other site 324057017768 putative CheW interface [polypeptide binding]; other site 324057017769 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 324057017770 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 324057017771 active site 324057017772 metal binding site [ion binding]; metal-binding site 324057017773 homodimer interface [polypeptide binding]; other site 324057017774 catalytic site [active] 324057017775 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 324057017776 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 324057017777 Uncharacterized conserved protein [Function unknown]; Region: COG3538 324057017778 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 324057017779 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057017780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017781 putative PBP binding loops; other site 324057017782 ABC-ATPase subunit interface; other site 324057017783 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057017784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017785 dimer interface [polypeptide binding]; other site 324057017786 conserved gate region; other site 324057017787 ABC-ATPase subunit interface; other site 324057017788 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057017789 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057017790 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057017791 Response regulator receiver domain; Region: Response_reg; pfam00072 324057017792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057017793 active site 324057017794 phosphorylation site [posttranslational modification] 324057017795 intermolecular recognition site; other site 324057017796 dimerization interface [polypeptide binding]; other site 324057017797 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057017798 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017799 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057017800 dimerization interface [polypeptide binding]; other site 324057017801 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057017802 Histidine kinase; Region: His_kinase; pfam06580 324057017803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057017804 ATP binding site [chemical binding]; other site 324057017805 Mg2+ binding site [ion binding]; other site 324057017806 G-X-G motif; other site 324057017807 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 324057017808 Putative esterase; Region: Esterase; pfam00756 324057017809 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 324057017810 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057017811 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057017812 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057017813 Type 1 glutamine amidotransferase (GATase1)-like domain found in Sinorhizobium meliloti Rm1021 ThuA (SmThuA); Region: GATase1_ThuA; cd03142 324057017814 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057017815 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057017816 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057017817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017818 dimer interface [polypeptide binding]; other site 324057017819 conserved gate region; other site 324057017820 putative PBP binding loops; other site 324057017821 ABC-ATPase subunit interface; other site 324057017822 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057017823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017824 dimer interface [polypeptide binding]; other site 324057017825 conserved gate region; other site 324057017826 ABC-ATPase subunit interface; other site 324057017827 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057017828 Histidine kinase; Region: His_kinase; pfam06580 324057017829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057017830 ATP binding site [chemical binding]; other site 324057017831 Mg2+ binding site [ion binding]; other site 324057017832 G-X-G motif; other site 324057017833 Response regulator receiver domain; Region: Response_reg; pfam00072 324057017834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057017835 active site 324057017836 phosphorylation site [posttranslational modification] 324057017837 intermolecular recognition site; other site 324057017838 dimerization interface [polypeptide binding]; other site 324057017839 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057017840 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017841 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 324057017842 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 324057017843 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057017844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057017845 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057017846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017847 dimer interface [polypeptide binding]; other site 324057017848 conserved gate region; other site 324057017849 putative PBP binding loops; other site 324057017850 ABC-ATPase subunit interface; other site 324057017851 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324057017852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017853 dimer interface [polypeptide binding]; other site 324057017854 conserved gate region; other site 324057017855 putative PBP binding loops; other site 324057017856 ABC-ATPase subunit interface; other site 324057017857 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057017858 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 324057017859 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 324057017860 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 324057017861 Penicillinase repressor; Region: Pencillinase_R; pfam03965 324057017862 short chain dehydrogenase; Provisional; Region: PRK06523 324057017863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057017864 NAD(P) binding site [chemical binding]; other site 324057017865 active site 324057017866 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057017867 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057017868 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057017869 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057017870 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057017871 dimerization interface [polypeptide binding]; other site 324057017872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057017873 dimer interface [polypeptide binding]; other site 324057017874 phosphorylation site [posttranslational modification] 324057017875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057017876 ATP binding site [chemical binding]; other site 324057017877 Mg2+ binding site [ion binding]; other site 324057017878 G-X-G motif; other site 324057017879 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057017880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057017881 active site 324057017882 phosphorylation site [posttranslational modification] 324057017883 intermolecular recognition site; other site 324057017884 dimerization interface [polypeptide binding]; other site 324057017885 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057017886 DNA binding site [nucleotide binding] 324057017887 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 324057017888 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 324057017889 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 324057017890 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 324057017891 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 324057017892 active site 324057017893 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 324057017894 dimer interface [polypeptide binding]; other site 324057017895 substrate binding site [chemical binding]; other site 324057017896 catalytic residues [active] 324057017897 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 324057017898 Acyltransferase family; Region: Acyl_transf_3; pfam01757 324057017899 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 324057017900 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057017901 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057017902 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017903 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017904 Sulfatase; Region: Sulfatase; cl17466 324057017905 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 324057017906 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324057017907 beta-D-glucuronidase; Provisional; Region: PRK10150 324057017908 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324057017909 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 324057017910 Glycosyl hydrolase family 79, N-terminal domain; Region: Glyco_hydro_79n; pfam03662 324057017911 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 324057017912 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057017913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017914 dimer interface [polypeptide binding]; other site 324057017915 conserved gate region; other site 324057017916 putative PBP binding loops; other site 324057017917 ABC-ATPase subunit interface; other site 324057017918 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057017919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057017920 dimer interface [polypeptide binding]; other site 324057017921 conserved gate region; other site 324057017922 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 324057017923 ABC-ATPase subunit interface; other site 324057017924 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057017925 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057017926 Response regulator receiver domain; Region: Response_reg; pfam00072 324057017927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057017928 active site 324057017929 phosphorylation site [posttranslational modification] 324057017930 intermolecular recognition site; other site 324057017931 dimerization interface [polypeptide binding]; other site 324057017932 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057017933 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017934 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057017935 Histidine kinase; Region: His_kinase; pfam06580 324057017936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057017937 ATP binding site [chemical binding]; other site 324057017938 Mg2+ binding site [ion binding]; other site 324057017939 G-X-G motif; other site 324057017940 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057017941 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017942 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057017943 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 324057017944 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057017945 active site 324057017946 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 324057017947 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324057017948 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324057017949 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324057017950 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324057017951 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324057017952 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324057017953 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 324057017954 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 324057017955 DNA binding residues [nucleotide binding] 324057017956 putative dimer interface [polypeptide binding]; other site 324057017957 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 324057017958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057017959 NAD(P) binding site [chemical binding]; other site 324057017960 active site 324057017961 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 324057017962 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 324057017963 glutaminase active site [active] 324057017964 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 324057017965 dimer interface [polypeptide binding]; other site 324057017966 active site 324057017967 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 324057017968 dimer interface [polypeptide binding]; other site 324057017969 active site 324057017970 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 324057017971 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 324057017972 active site 324057017973 substrate binding site [chemical binding]; other site 324057017974 metal binding site [ion binding]; metal-binding site 324057017975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 324057017976 YbbR-like protein; Region: YbbR; pfam07949 324057017977 TIGR00159 family protein; Region: TIGR00159 324057017978 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 324057017979 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 324057017980 Putative zinc-finger; Region: zf-HC2; pfam13490 324057017981 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 324057017982 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 324057017983 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057017984 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057017985 DNA binding residues [nucleotide binding] 324057017986 EamA-like transporter family; Region: EamA; pfam00892 324057017987 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 324057017988 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 324057017989 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 324057017990 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 324057017991 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 324057017992 Walker A/P-loop; other site 324057017993 ATP binding site [chemical binding]; other site 324057017994 Q-loop/lid; other site 324057017995 ABC transporter signature motif; other site 324057017996 Walker B; other site 324057017997 D-loop; other site 324057017998 H-loop/switch region; other site 324057017999 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 324057018000 dimer interface [polypeptide binding]; other site 324057018001 FMN binding site [chemical binding]; other site 324057018002 NADPH bind site [chemical binding]; other site 324057018003 Integral membrane protein DUF95; Region: DUF95; pfam01944 324057018004 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 324057018005 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 324057018006 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 324057018007 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 324057018008 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 324057018009 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 324057018010 active site 324057018011 metal binding site [ion binding]; metal-binding site 324057018012 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 324057018013 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 324057018014 Active Sites [active] 324057018015 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 324057018016 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 324057018017 23S rRNA interface [nucleotide binding]; other site 324057018018 L3 interface [polypeptide binding]; other site 324057018019 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 324057018020 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 324057018021 dimerization interface 3.5A [polypeptide binding]; other site 324057018022 active site 324057018023 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 324057018024 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 324057018025 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 324057018026 alphaNTD - beta interaction site [polypeptide binding]; other site 324057018027 alphaNTD homodimer interface [polypeptide binding]; other site 324057018028 alphaNTD - beta' interaction site [polypeptide binding]; other site 324057018029 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 324057018030 30S ribosomal protein S11; Validated; Region: PRK05309 324057018031 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 324057018032 30S ribosomal protein S13; Region: bact_S13; TIGR03631 324057018033 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 324057018034 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 324057018035 rRNA binding site [nucleotide binding]; other site 324057018036 predicted 30S ribosome binding site; other site 324057018037 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 324057018038 RNA binding site [nucleotide binding]; other site 324057018039 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 324057018040 active site 324057018041 adenylate kinase; Reviewed; Region: adk; PRK00279 324057018042 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 324057018043 AMP-binding site [chemical binding]; other site 324057018044 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 324057018045 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 324057018046 SecY translocase; Region: SecY; pfam00344 324057018047 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 324057018048 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 324057018049 23S rRNA binding site [nucleotide binding]; other site 324057018050 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 324057018051 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 324057018052 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 324057018053 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 324057018054 5S rRNA interface [nucleotide binding]; other site 324057018055 L27 interface [polypeptide binding]; other site 324057018056 23S rRNA interface [nucleotide binding]; other site 324057018057 L5 interface [polypeptide binding]; other site 324057018058 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 324057018059 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 324057018060 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 324057018061 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 324057018062 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 324057018063 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 324057018064 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 324057018065 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 324057018066 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 324057018067 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 324057018068 RNA binding site [nucleotide binding]; other site 324057018069 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 324057018070 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 324057018071 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 324057018072 23S rRNA interface [nucleotide binding]; other site 324057018073 putative translocon interaction site; other site 324057018074 signal recognition particle (SRP54) interaction site; other site 324057018075 L23 interface [polypeptide binding]; other site 324057018076 trigger factor interaction site; other site 324057018077 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 324057018078 23S rRNA interface [nucleotide binding]; other site 324057018079 5S rRNA interface [nucleotide binding]; other site 324057018080 putative antibiotic binding site [chemical binding]; other site 324057018081 L25 interface [polypeptide binding]; other site 324057018082 L27 interface [polypeptide binding]; other site 324057018083 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 324057018084 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 324057018085 G-X-X-G motif; other site 324057018086 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 324057018087 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 324057018088 putative translocon binding site; other site 324057018089 protein-rRNA interface [nucleotide binding]; other site 324057018090 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 324057018091 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 324057018092 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 324057018093 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 324057018094 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 324057018095 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 324057018096 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 324057018097 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 324057018098 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 324057018099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057018100 Walker A/P-loop; other site 324057018101 ATP binding site [chemical binding]; other site 324057018102 Q-loop/lid; other site 324057018103 ABC transporter signature motif; other site 324057018104 Walker B; other site 324057018105 D-loop; other site 324057018106 H-loop/switch region; other site 324057018107 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 324057018108 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 324057018109 TM-ABC transporter signature motif; other site 324057018110 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 324057018111 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 324057018112 zinc binding site [ion binding]; other site 324057018113 putative ligand binding site [chemical binding]; other site 324057018114 elongation factor Tu; Reviewed; Region: PRK00049 324057018115 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 324057018116 G1 box; other site 324057018117 GEF interaction site [polypeptide binding]; other site 324057018118 GTP/Mg2+ binding site [chemical binding]; other site 324057018119 Switch I region; other site 324057018120 G2 box; other site 324057018121 G3 box; other site 324057018122 Switch II region; other site 324057018123 G4 box; other site 324057018124 G5 box; other site 324057018125 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 324057018126 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 324057018127 Antibiotic Binding Site [chemical binding]; other site 324057018128 elongation factor G; Reviewed; Region: PRK00007 324057018129 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 324057018130 G1 box; other site 324057018131 putative GEF interaction site [polypeptide binding]; other site 324057018132 GTP/Mg2+ binding site [chemical binding]; other site 324057018133 Switch I region; other site 324057018134 G2 box; other site 324057018135 G3 box; other site 324057018136 Switch II region; other site 324057018137 G4 box; other site 324057018138 G5 box; other site 324057018139 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 324057018140 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 324057018141 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 324057018142 30S ribosomal protein S7; Validated; Region: PRK05302 324057018143 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 324057018144 S17 interaction site [polypeptide binding]; other site 324057018145 S8 interaction site; other site 324057018146 16S rRNA interaction site [nucleotide binding]; other site 324057018147 streptomycin interaction site [chemical binding]; other site 324057018148 23S rRNA interaction site [nucleotide binding]; other site 324057018149 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 324057018150 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 324057018151 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 324057018152 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 324057018153 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 324057018154 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 324057018155 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 324057018156 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 324057018157 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 324057018158 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 324057018159 G-loop; other site 324057018160 DNA binding site [nucleotide binding] 324057018161 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 324057018162 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 324057018163 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 324057018164 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 324057018165 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 324057018166 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 324057018167 RPB12 interaction site [polypeptide binding]; other site 324057018168 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 324057018169 RPB10 interaction site [polypeptide binding]; other site 324057018170 RPB1 interaction site [polypeptide binding]; other site 324057018171 RPB11 interaction site [polypeptide binding]; other site 324057018172 RPB3 interaction site [polypeptide binding]; other site 324057018173 RPB12 interaction site [polypeptide binding]; other site 324057018174 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324057018175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057018176 S-adenosylmethionine binding site [chemical binding]; other site 324057018177 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 324057018178 core dimer interface [polypeptide binding]; other site 324057018179 peripheral dimer interface [polypeptide binding]; other site 324057018180 L10 interface [polypeptide binding]; other site 324057018181 L11 interface [polypeptide binding]; other site 324057018182 putative EF-Tu interaction site [polypeptide binding]; other site 324057018183 putative EF-G interaction site [polypeptide binding]; other site 324057018184 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 324057018185 23S rRNA interface [nucleotide binding]; other site 324057018186 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 324057018187 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 324057018188 mRNA/rRNA interface [nucleotide binding]; other site 324057018189 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 324057018190 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 324057018191 23S rRNA interface [nucleotide binding]; other site 324057018192 L7/L12 interface [polypeptide binding]; other site 324057018193 putative thiostrepton binding site; other site 324057018194 L25 interface [polypeptide binding]; other site 324057018195 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 324057018196 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 324057018197 putative homodimer interface [polypeptide binding]; other site 324057018198 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 324057018199 heterodimer interface [polypeptide binding]; other site 324057018200 homodimer interface [polypeptide binding]; other site 324057018201 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 324057018202 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 324057018203 RNA polymerase factor sigma-70; Validated; Region: PRK08295 324057018204 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057018205 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 324057018206 YacP-like NYN domain; Region: NYN_YacP; pfam05991 324057018207 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 324057018208 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 324057018209 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 324057018210 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 324057018211 active site 324057018212 metal binding site [ion binding]; metal-binding site 324057018213 dimerization interface [polypeptide binding]; other site 324057018214 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 324057018215 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 324057018216 active site 324057018217 HIGH motif; other site 324057018218 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 324057018219 KMSKS motif; other site 324057018220 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 324057018221 anticodon binding site; other site 324057018222 tRNA binding surface [nucleotide binding]; other site 324057018223 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 324057018224 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 324057018225 serine O-acetyltransferase; Region: cysE; TIGR01172 324057018226 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 324057018227 trimer interface [polypeptide binding]; other site 324057018228 active site 324057018229 substrate binding site [chemical binding]; other site 324057018230 CoA binding site [chemical binding]; other site 324057018231 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 324057018232 homotrimer interaction site [polypeptide binding]; other site 324057018233 zinc binding site [ion binding]; other site 324057018234 CDP-binding sites; other site 324057018235 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 324057018236 substrate binding site; other site 324057018237 dimer interface; other site 324057018238 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 324057018239 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 324057018240 putative active site [active] 324057018241 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 324057018242 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 324057018243 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 324057018244 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 324057018245 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 324057018246 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 324057018247 DNA repair protein RadA; Provisional; Region: PRK11823 324057018248 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 324057018249 Walker A motif/ATP binding site; other site 324057018250 ATP binding site [chemical binding]; other site 324057018251 Walker B motif; other site 324057018252 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 324057018253 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 324057018254 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 324057018255 Clp amino terminal domain; Region: Clp_N; pfam02861 324057018256 Clp amino terminal domain; Region: Clp_N; pfam02861 324057018257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057018258 Walker A motif; other site 324057018259 ATP binding site [chemical binding]; other site 324057018260 Walker B motif; other site 324057018261 arginine finger; other site 324057018262 UvrB/uvrC motif; Region: UVR; pfam02151 324057018263 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324057018264 Walker A motif; other site 324057018265 ATP binding site [chemical binding]; other site 324057018266 Walker B motif; other site 324057018267 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 324057018268 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 324057018269 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 324057018270 ADP binding site [chemical binding]; other site 324057018271 phosphagen binding site; other site 324057018272 substrate specificity loop; other site 324057018273 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 324057018274 UvrB/uvrC motif; Region: UVR; pfam02151 324057018275 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 324057018276 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 324057018277 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 324057018278 nucleotide binding pocket [chemical binding]; other site 324057018279 K-X-D-G motif; other site 324057018280 catalytic site [active] 324057018281 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 324057018282 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 324057018283 Dimer interface [polypeptide binding]; other site 324057018284 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 324057018285 Part of AAA domain; Region: AAA_19; pfam13245 324057018286 Family description; Region: UvrD_C_2; pfam13538 324057018287 PcrB family; Region: PcrB; pfam01884 324057018288 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 324057018289 substrate binding site [chemical binding]; other site 324057018290 putative active site [active] 324057018291 dimer interface [polypeptide binding]; other site 324057018292 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 324057018293 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 324057018294 Peptidase family U32; Region: Peptidase_U32; pfam01136 324057018295 Collagenase; Region: DUF3656; pfam12392 324057018296 Peptidase family U32; Region: Peptidase_U32; cl03113 324057018297 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057018298 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 324057018299 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 324057018300 protein binding site [polypeptide binding]; other site 324057018301 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057018302 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 324057018303 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057018304 putative DNA binding site [nucleotide binding]; other site 324057018305 dimerization interface [polypeptide binding]; other site 324057018306 putative Zn2+ binding site [ion binding]; other site 324057018307 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 324057018308 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 324057018309 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 324057018310 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 324057018311 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 324057018312 excinuclease ABC subunit B; Provisional; Region: PRK05298 324057018313 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057018314 ATP binding site [chemical binding]; other site 324057018315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057018316 nucleotide binding region [chemical binding]; other site 324057018317 ATP-binding site [chemical binding]; other site 324057018318 Ultra-violet resistance protein B; Region: UvrB; pfam12344 324057018319 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 324057018320 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 324057018321 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 324057018322 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 324057018323 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 324057018324 protein binding site [polypeptide binding]; other site 324057018325 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 324057018326 Catalytic dyad [active] 324057018327 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 324057018328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 324057018329 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 324057018330 Peptidase family M23; Region: Peptidase_M23; pfam01551 324057018331 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 324057018332 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 324057018333 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 324057018334 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 324057018335 Walker A/P-loop; other site 324057018336 ATP binding site [chemical binding]; other site 324057018337 Q-loop/lid; other site 324057018338 ABC transporter signature motif; other site 324057018339 Walker B; other site 324057018340 D-loop; other site 324057018341 H-loop/switch region; other site 324057018342 VanW like protein; Region: VanW; pfam04294 324057018343 G5 domain; Region: G5; pfam07501 324057018344 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 324057018345 putative active site [active] 324057018346 argininosuccinate lyase; Provisional; Region: PRK00855 324057018347 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 324057018348 active sites [active] 324057018349 tetramer interface [polypeptide binding]; other site 324057018350 argininosuccinate synthase; Provisional; Region: PRK13820 324057018351 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 324057018352 ANP binding site [chemical binding]; other site 324057018353 Substrate Binding Site II [chemical binding]; other site 324057018354 Substrate Binding Site I [chemical binding]; other site 324057018355 ornithine carbamoyltransferase; Provisional; Region: PRK00779 324057018356 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 324057018357 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 324057018358 acetylornithine aminotransferase; Provisional; Region: PRK02627 324057018359 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324057018360 inhibitor-cofactor binding pocket; inhibition site 324057018361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057018362 catalytic residue [active] 324057018363 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 324057018364 nucleotide binding site [chemical binding]; other site 324057018365 N-acetyl-L-glutamate binding site [chemical binding]; other site 324057018366 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 324057018367 heterotetramer interface [polypeptide binding]; other site 324057018368 active site pocket [active] 324057018369 cleavage site 324057018370 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 324057018371 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 324057018372 Uncharacterized conserved protein [Function unknown]; Region: COG1284 324057018373 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324057018374 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324057018375 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 324057018376 peptide chain release factor 2; Validated; Region: prfB; PRK00578 324057018377 This domain is found in peptide chain release factors; Region: PCRF; smart00937 324057018378 RF-1 domain; Region: RF-1; pfam00472 324057018379 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 324057018380 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 324057018381 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 324057018382 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057018383 nucleotide binding region [chemical binding]; other site 324057018384 ATP-binding site [chemical binding]; other site 324057018385 SEC-C motif; Region: SEC-C; pfam02810 324057018386 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 324057018387 30S subunit binding site; other site 324057018388 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 324057018389 DNA-binding site [nucleotide binding]; DNA binding site 324057018390 RNA-binding motif; other site 324057018391 Flagellar protein FliS; Region: FliS; cl00654 324057018392 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 324057018393 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 324057018394 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 324057018395 FlaG protein; Region: FlaG; pfam03646 324057018396 UDP-glucose 4-epimerase; Region: PLN02240 324057018397 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 324057018398 NAD binding site [chemical binding]; other site 324057018399 homodimer interface [polypeptide binding]; other site 324057018400 active site 324057018401 substrate binding site [chemical binding]; other site 324057018402 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 324057018403 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057018404 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057018405 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 324057018406 trimer interface [polypeptide binding]; other site 324057018407 active site 324057018408 substrate binding site [chemical binding]; other site 324057018409 CoA binding site [chemical binding]; other site 324057018410 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057018411 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057018412 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 324057018413 putative metal binding site; other site 324057018414 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057018415 binding surface 324057018416 TPR motif; other site 324057018417 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324057018418 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 324057018419 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 324057018420 carbon storage regulator; Provisional; Region: PRK01712 324057018421 FliW protein; Region: FliW; cl00740 324057018422 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 324057018423 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 324057018424 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 324057018425 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 324057018426 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 324057018427 FlgN protein; Region: FlgN; pfam05130 324057018428 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 324057018429 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 324057018430 comF family protein; Region: comF; TIGR00201 324057018431 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057018432 active site 324057018433 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324057018434 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 324057018435 ATP binding site [chemical binding]; other site 324057018436 putative Mg++ binding site [ion binding]; other site 324057018437 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324057018438 nucleotide binding region [chemical binding]; other site 324057018439 ATP-binding site [chemical binding]; other site 324057018440 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 324057018441 putative Zn2+ binding site [ion binding]; other site 324057018442 putative DNA binding site [nucleotide binding]; other site 324057018443 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057018444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057018445 active site 324057018446 phosphorylation site [posttranslational modification] 324057018447 intermolecular recognition site; other site 324057018448 dimerization interface [polypeptide binding]; other site 324057018449 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057018450 DNA binding residues [nucleotide binding] 324057018451 dimerization interface [polypeptide binding]; other site 324057018452 Sensor protein DegS; Region: DegS; pfam05384 324057018453 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324057018454 Histidine kinase; Region: HisKA_3; pfam07730 324057018455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057018456 ATP binding site [chemical binding]; other site 324057018457 Mg2+ binding site [ion binding]; other site 324057018458 G-X-G motif; other site 324057018459 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 324057018460 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057018461 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057018462 Bacterial Ig-like domain; Region: Big_5; pfam13205 324057018463 Bacterial Ig-like domain; Region: Big_5; pfam13205 324057018464 Bacterial Ig-like domain; Region: Big_5; pfam13205 324057018465 Bacterial Ig-like domain; Region: Big_5; pfam13205 324057018466 Bacterial Ig-like domain; Region: Big_5; pfam13205 324057018467 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 324057018468 S-layer homology domain; Region: SLH; pfam00395 324057018469 S-layer homology domain; Region: SLH; pfam00395 324057018470 S-layer homology domain; Region: SLH; pfam00395 324057018471 S-adenosylmethionine synthetase; Validated; Region: PRK05250 324057018472 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 324057018473 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 324057018474 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 324057018475 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 324057018476 S-layer homology domain; Region: SLH; pfam00395 324057018477 S-layer homology domain; Region: SLH; pfam00395 324057018478 S-layer homology domain; Region: SLH; pfam00395 324057018479 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 324057018480 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 324057018481 Mg++ binding site [ion binding]; other site 324057018482 putative catalytic motif [active] 324057018483 substrate binding site [chemical binding]; other site 324057018484 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 324057018485 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 324057018486 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 324057018487 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 324057018488 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 324057018489 active site 324057018490 substrate binding site [chemical binding]; other site 324057018491 metal binding site [ion binding]; metal-binding site 324057018492 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 324057018493 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 324057018494 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 324057018495 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 324057018496 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 324057018497 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 324057018498 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 324057018499 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 324057018500 rod shape-determining protein Mbl; Provisional; Region: PRK13928 324057018501 MreB and similar proteins; Region: MreB_like; cd10225 324057018502 nucleotide binding site [chemical binding]; other site 324057018503 Mg binding site [ion binding]; other site 324057018504 putative protofilament interaction site [polypeptide binding]; other site 324057018505 RodZ interaction site [polypeptide binding]; other site 324057018506 Stage III sporulation protein D; Region: SpoIIID; pfam12116 324057018507 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 324057018508 Peptidase family M23; Region: Peptidase_M23; pfam01551 324057018509 Stage II sporulation protein; Region: SpoIID; pfam08486 324057018510 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 324057018511 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 324057018512 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 324057018513 FtsX-like permease family; Region: FtsX; pfam02687 324057018514 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057018515 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 324057018516 Walker A/P-loop; other site 324057018517 ATP binding site [chemical binding]; other site 324057018518 Q-loop/lid; other site 324057018519 ABC transporter signature motif; other site 324057018520 Walker B; other site 324057018521 D-loop; other site 324057018522 H-loop/switch region; other site 324057018523 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 324057018524 HlyD family secretion protein; Region: HlyD_3; pfam13437 324057018525 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 324057018526 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 324057018527 hinge; other site 324057018528 active site 324057018529 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 324057018530 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 324057018531 active site 324057018532 catalytic residues [active] 324057018533 S-layer homology domain; Region: SLH; pfam00395 324057018534 S-layer homology domain; Region: SLH; pfam00395 324057018535 S-layer homology domain; Region: SLH; pfam00395 324057018536 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 324057018537 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 324057018538 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 324057018539 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 324057018540 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 324057018541 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 324057018542 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 324057018543 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 324057018544 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 324057018545 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 324057018546 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 324057018547 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 324057018548 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 324057018549 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 324057018550 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 324057018551 NADH dehydrogenase subunit B; Validated; Region: PRK06411 324057018552 NADH dehydrogenase subunit A; Validated; Region: PRK07756 324057018553 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057018554 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057018555 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057018556 dimer interface [polypeptide binding]; other site 324057018557 putative CheW interface [polypeptide binding]; other site 324057018558 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 324057018559 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057018560 ABC-ATPase subunit interface; other site 324057018561 dimer interface [polypeptide binding]; other site 324057018562 putative PBP binding regions; other site 324057018563 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057018564 ABC-ATPase subunit interface; other site 324057018565 dimer interface [polypeptide binding]; other site 324057018566 putative PBP binding regions; other site 324057018567 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 324057018568 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057018569 siderophore binding site; other site 324057018570 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 324057018571 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 324057018572 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 324057018573 gamma subunit interface [polypeptide binding]; other site 324057018574 epsilon subunit interface [polypeptide binding]; other site 324057018575 LBP interface [polypeptide binding]; other site 324057018576 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 324057018577 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 324057018578 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 324057018579 alpha subunit interaction interface [polypeptide binding]; other site 324057018580 Walker A motif; other site 324057018581 ATP binding site [chemical binding]; other site 324057018582 Walker B motif; other site 324057018583 inhibitor binding site; inhibition site 324057018584 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 324057018585 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 324057018586 core domain interface [polypeptide binding]; other site 324057018587 delta subunit interface [polypeptide binding]; other site 324057018588 epsilon subunit interface [polypeptide binding]; other site 324057018589 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 324057018590 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 324057018591 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 324057018592 beta subunit interaction interface [polypeptide binding]; other site 324057018593 Walker A motif; other site 324057018594 ATP binding site [chemical binding]; other site 324057018595 Walker B motif; other site 324057018596 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 324057018597 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 324057018598 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 324057018599 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 324057018600 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 324057018601 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 324057018602 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 324057018603 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 324057018604 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 324057018605 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 324057018606 active site 324057018607 homodimer interface [polypeptide binding]; other site 324057018608 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324057018609 active site 324057018610 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 324057018611 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324057018612 Walker A/P-loop; other site 324057018613 ATP binding site [chemical binding]; other site 324057018614 Q-loop/lid; other site 324057018615 ABC transporter signature motif; other site 324057018616 Walker B; other site 324057018617 D-loop; other site 324057018618 H-loop/switch region; other site 324057018619 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 324057018620 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 324057018621 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324057018622 Walker A/P-loop; other site 324057018623 ATP binding site [chemical binding]; other site 324057018624 Q-loop/lid; other site 324057018625 ABC transporter signature motif; other site 324057018626 Walker B; other site 324057018627 D-loop; other site 324057018628 H-loop/switch region; other site 324057018629 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 324057018630 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 324057018631 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 324057018632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057018633 dimer interface [polypeptide binding]; other site 324057018634 conserved gate region; other site 324057018635 putative PBP binding loops; other site 324057018636 ABC-ATPase subunit interface; other site 324057018637 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 324057018638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057018639 dimer interface [polypeptide binding]; other site 324057018640 conserved gate region; other site 324057018641 putative PBP binding loops; other site 324057018642 ABC-ATPase subunit interface; other site 324057018643 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 324057018644 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 324057018645 peptide binding site [polypeptide binding]; other site 324057018646 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 324057018647 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 324057018648 dimer interface [polypeptide binding]; other site 324057018649 active site 324057018650 glycine-pyridoxal phosphate binding site [chemical binding]; other site 324057018651 folate binding site [chemical binding]; other site 324057018652 hypothetical protein; Provisional; Region: PRK13690 324057018653 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 324057018654 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 324057018655 Low molecular weight phosphatase family; Region: LMWPc; cd00115 324057018656 active site 324057018657 Predicted membrane protein [Function unknown]; Region: COG1971 324057018658 Domain of unknown function DUF; Region: DUF204; pfam02659 324057018659 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 324057018660 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 324057018661 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 324057018662 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 324057018663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 324057018664 peptide chain release factor 1; Validated; Region: prfA; PRK00591 324057018665 This domain is found in peptide chain release factors; Region: PCRF; smart00937 324057018666 RF-1 domain; Region: RF-1; pfam00472 324057018667 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 324057018668 CopC domain; Region: CopC; pfam04234 324057018669 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 324057018670 GTP-binding protein YchF; Reviewed; Region: PRK09601 324057018671 YchF GTPase; Region: YchF; cd01900 324057018672 G1 box; other site 324057018673 GTP/Mg2+ binding site [chemical binding]; other site 324057018674 Switch I region; other site 324057018675 G2 box; other site 324057018676 Switch II region; other site 324057018677 G3 box; other site 324057018678 G4 box; other site 324057018679 G5 box; other site 324057018680 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 324057018681 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 324057018682 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 324057018683 Probable Catalytic site; other site 324057018684 Methyltransferase domain; Region: Methyltransf_23; pfam13489 324057018685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057018686 S-adenosylmethionine binding site [chemical binding]; other site 324057018687 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324057018688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057018689 S-adenosylmethionine binding site [chemical binding]; other site 324057018690 S-layer homology domain; Region: SLH; pfam00395 324057018691 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057018692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057018693 dimer interface [polypeptide binding]; other site 324057018694 conserved gate region; other site 324057018695 putative PBP binding loops; other site 324057018696 ABC-ATPase subunit interface; other site 324057018697 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057018698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057018699 dimer interface [polypeptide binding]; other site 324057018700 conserved gate region; other site 324057018701 putative PBP binding loops; other site 324057018702 ABC-ATPase subunit interface; other site 324057018703 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057018704 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057018705 Helix-turn-helix domain; Region: HTH_18; pfam12833 324057018706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057018707 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324057018708 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324057018709 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324057018710 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 324057018711 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324057018712 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057018713 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057018714 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 324057018715 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 324057018716 catalytic residues [active] 324057018717 Transcriptional regulator; Region: Rrf2; pfam02082 324057018718 Rrf2 family protein; Region: rrf2_super; TIGR00738 324057018719 Transcriptional regulator; Region: Rrf2; cl17282 324057018720 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 324057018721 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 324057018722 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 324057018723 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 324057018724 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 324057018725 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 324057018726 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324057018727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324057018728 homodimer interface [polypeptide binding]; other site 324057018729 catalytic residue [active] 324057018730 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 324057018731 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057018732 Coenzyme A binding pocket [chemical binding]; other site 324057018733 RDD family; Region: RDD; pfam06271 324057018734 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 324057018735 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324057018736 active site 324057018737 HIGH motif; other site 324057018738 nucleotide binding site [chemical binding]; other site 324057018739 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 324057018740 KMSKS motif; other site 324057018741 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 324057018742 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 324057018743 Na2 binding site [ion binding]; other site 324057018744 putative substrate binding site 1 [chemical binding]; other site 324057018745 Na binding site 1 [ion binding]; other site 324057018746 putative substrate binding site 2 [chemical binding]; other site 324057018747 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057018748 active site 324057018749 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057018750 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324057018751 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 324057018752 putative metal binding site; other site 324057018753 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057018754 binding surface 324057018755 TPR motif; other site 324057018756 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 324057018757 putative metal binding site; other site 324057018758 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 324057018759 putative metal binding site; other site 324057018760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 324057018761 binding surface 324057018762 TPR motif; other site 324057018763 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 324057018764 catalytic residues [active] 324057018765 dimer interface [polypeptide binding]; other site 324057018766 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 324057018767 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057018768 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057018769 active site 324057018770 catalytic tetrad [active] 324057018771 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 324057018772 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 324057018773 tetramer interface [polypeptide binding]; other site 324057018774 heme binding pocket [chemical binding]; other site 324057018775 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057018776 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057018777 DNA binding site [nucleotide binding] 324057018778 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 324057018779 metal binding site 2 [ion binding]; metal-binding site 324057018780 putative DNA binding helix; other site 324057018781 metal binding site 1 [ion binding]; metal-binding site 324057018782 dimer interface [polypeptide binding]; other site 324057018783 structural Zn2+ binding site [ion binding]; other site 324057018784 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 324057018785 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 324057018786 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 324057018787 putative active site [active] 324057018788 catalytic site [active] 324057018789 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 324057018790 putative active site [active] 324057018791 catalytic site [active] 324057018792 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 324057018793 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324057018794 Zn2+ binding site [ion binding]; other site 324057018795 Mg2+ binding site [ion binding]; other site 324057018796 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 324057018797 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 324057018798 active site 324057018799 dimerization interface [polypeptide binding]; other site 324057018800 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 324057018801 PT repeat; Region: PT; pfam04886 324057018802 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 324057018803 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 324057018804 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 324057018805 Sulfatase; Region: Sulfatase; pfam00884 324057018806 S-layer homology domain; Region: SLH; pfam00395 324057018807 S-layer homology domain; Region: SLH; pfam00395 324057018808 S-layer homology domain; Region: SLH; pfam00395 324057018809 S-layer homology domain; Region: SLH; pfam00395 324057018810 S-layer homology domain; Region: SLH; pfam00395 324057018811 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057018812 active site 324057018813 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057018814 catalytic tetrad [active] 324057018815 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057018816 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 324057018817 active site 324057018818 metal binding site [ion binding]; metal-binding site 324057018819 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 324057018820 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 324057018821 catalytic triad [active] 324057018822 Asparaginase, found in various plant, animal and bacterial cells; Region: Asparaginase; smart00870 324057018823 active site 324057018824 homodimer interface [polypeptide binding]; other site 324057018825 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 324057018826 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 324057018827 Amidase; Region: Amidase; cl11426 324057018828 indole-3-acetamide amidohydrolase; Region: PLN02722 324057018829 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 324057018830 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 324057018831 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 324057018832 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324057018833 putative DNA binding site [nucleotide binding]; other site 324057018834 putative Zn2+ binding site [ion binding]; other site 324057018835 AsnC family; Region: AsnC_trans_reg; pfam01037 324057018836 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 324057018837 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 324057018838 MMPL family; Region: MMPL; pfam03176 324057018839 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 324057018840 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 324057018841 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057018842 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 324057018843 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 324057018844 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 324057018845 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057018846 dimerization interface [polypeptide binding]; other site 324057018847 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324057018848 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057018849 dimer interface [polypeptide binding]; other site 324057018850 putative CheW interface [polypeptide binding]; other site 324057018851 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324057018852 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 324057018853 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 324057018854 Walker A/P-loop; other site 324057018855 ATP binding site [chemical binding]; other site 324057018856 Q-loop/lid; other site 324057018857 ABC transporter signature motif; other site 324057018858 Walker B; other site 324057018859 D-loop; other site 324057018860 H-loop/switch region; other site 324057018861 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324057018862 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 324057018863 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324057018864 Walker A/P-loop; other site 324057018865 ATP binding site [chemical binding]; other site 324057018866 Q-loop/lid; other site 324057018867 ABC transporter signature motif; other site 324057018868 Walker B; other site 324057018869 D-loop; other site 324057018870 H-loop/switch region; other site 324057018871 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 324057018872 active site 324057018873 SAM binding site [chemical binding]; other site 324057018874 homodimer interface [polypeptide binding]; other site 324057018875 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 324057018876 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 324057018877 [2Fe-2S] cluster binding site [ion binding]; other site 324057018878 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 324057018879 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324057018880 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 324057018881 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 324057018882 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 324057018883 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 324057018884 ANTAR domain; Region: ANTAR; pfam03861 324057018885 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 324057018886 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 324057018887 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 324057018888 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 324057018889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057018890 putative substrate translocation pore; other site 324057018891 Cold-inducible protein YdjO; Region: YdjO; pfam14169 324057018892 Pirin-related protein [General function prediction only]; Region: COG1741 324057018893 Pirin; Region: Pirin; pfam02678 324057018894 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 324057018895 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 324057018896 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 324057018897 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 324057018898 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 324057018899 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057018900 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057018901 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057018902 dimerization interface [polypeptide binding]; other site 324057018903 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 324057018904 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 324057018905 dimer interface [polypeptide binding]; other site 324057018906 active site 324057018907 catalytic residue [active] 324057018908 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 324057018909 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324057018910 active site 324057018911 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324057018912 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 324057018913 active site 324057018914 catalytic tetrad [active] 324057018915 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057018916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057018917 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 324057018918 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 324057018919 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 324057018920 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 324057018921 catalytic residues [active] 324057018922 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 324057018923 active site 1 [active] 324057018924 dimer interface [polypeptide binding]; other site 324057018925 hexamer interface [polypeptide binding]; other site 324057018926 active site 2 [active] 324057018927 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057018928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057018929 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 324057018930 putative dimerization interface [polypeptide binding]; other site 324057018931 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 324057018932 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 324057018933 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 324057018934 G1 box; other site 324057018935 putative GEF interaction site [polypeptide binding]; other site 324057018936 GTP/Mg2+ binding site [chemical binding]; other site 324057018937 Switch I region; other site 324057018938 G2 box; other site 324057018939 G3 box; other site 324057018940 Switch II region; other site 324057018941 G4 box; other site 324057018942 G5 box; other site 324057018943 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 324057018944 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 324057018945 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 324057018946 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 324057018947 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 324057018948 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 324057018949 active site 324057018950 metal binding site [ion binding]; metal-binding site 324057018951 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 324057018952 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057018953 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 324057018954 active site 324057018955 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057018956 dimerization interface [polypeptide binding]; other site 324057018957 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 324057018958 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057018959 putative active site [active] 324057018960 heme pocket [chemical binding]; other site 324057018961 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057018962 dimer interface [polypeptide binding]; other site 324057018963 phosphorylation site [posttranslational modification] 324057018964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057018965 ATP binding site [chemical binding]; other site 324057018966 Mg2+ binding site [ion binding]; other site 324057018967 G-X-G motif; other site 324057018968 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057018969 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 324057018970 Walker A/P-loop; other site 324057018971 ATP binding site [chemical binding]; other site 324057018972 Q-loop/lid; other site 324057018973 ABC transporter signature motif; other site 324057018974 Walker B; other site 324057018975 D-loop; other site 324057018976 H-loop/switch region; other site 324057018977 FtsX-like permease family; Region: FtsX; pfam02687 324057018978 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 324057018979 FtsX-like permease family; Region: FtsX; pfam02687 324057018980 HlyD family secretion protein; Region: HlyD_2; pfam12700 324057018981 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 324057018982 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057018983 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 324057018984 Walker A/P-loop; other site 324057018985 ATP binding site [chemical binding]; other site 324057018986 Q-loop/lid; other site 324057018987 ABC transporter signature motif; other site 324057018988 Walker B; other site 324057018989 D-loop; other site 324057018990 H-loop/switch region; other site 324057018991 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 324057018992 trimer interface [polypeptide binding]; other site 324057018993 active site 324057018994 substrate binding site [chemical binding]; other site 324057018995 CoA binding site [chemical binding]; other site 324057018996 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 324057018997 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 324057018998 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 324057018999 synthetase active site [active] 324057019000 NTP binding site [chemical binding]; other site 324057019001 metal binding site [ion binding]; metal-binding site 324057019002 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 324057019003 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 324057019004 Uncharacterized conserved protein [Function unknown]; Region: COG2966 324057019005 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 324057019006 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 324057019007 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 324057019008 FeoC like transcriptional regulator; Region: FeoC; cl17677 324057019009 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324057019010 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 324057019011 Response regulator receiver domain; Region: Response_reg; pfam00072 324057019012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057019013 active site 324057019014 phosphorylation site [posttranslational modification] 324057019015 intermolecular recognition site; other site 324057019016 dimerization interface [polypeptide binding]; other site 324057019017 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057019018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057019019 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057019020 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057019021 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057019022 dimerization interface [polypeptide binding]; other site 324057019023 Histidine kinase; Region: His_kinase; pfam06580 324057019024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057019025 ATP binding site [chemical binding]; other site 324057019026 Mg2+ binding site [ion binding]; other site 324057019027 G-X-G motif; other site 324057019028 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057019029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057019030 dimer interface [polypeptide binding]; other site 324057019031 conserved gate region; other site 324057019032 putative PBP binding loops; other site 324057019033 ABC-ATPase subunit interface; other site 324057019034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057019035 dimer interface [polypeptide binding]; other site 324057019036 conserved gate region; other site 324057019037 putative PBP binding loops; other site 324057019038 ABC-ATPase subunit interface; other site 324057019039 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057019040 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057019041 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 324057019042 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 324057019043 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 324057019044 NADH(P)-binding; Region: NAD_binding_10; pfam13460 324057019045 NAD binding site [chemical binding]; other site 324057019046 substrate binding site [chemical binding]; other site 324057019047 putative active site [active] 324057019048 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 324057019049 catalytic residues [active] 324057019050 dimer interface [polypeptide binding]; other site 324057019051 MarR family; Region: MarR_2; cl17246 324057019052 Predicted transcriptional regulators [Transcription]; Region: COG1725 324057019053 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057019054 DNA-binding site [nucleotide binding]; DNA binding site 324057019055 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 324057019056 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 324057019057 Walker A/P-loop; other site 324057019058 ATP binding site [chemical binding]; other site 324057019059 Q-loop/lid; other site 324057019060 ABC transporter signature motif; other site 324057019061 Walker B; other site 324057019062 D-loop; other site 324057019063 H-loop/switch region; other site 324057019064 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 324057019065 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 324057019066 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 324057019067 NAD binding site [chemical binding]; other site 324057019068 Phe binding site; other site 324057019069 peptidase T; Region: peptidase-T; TIGR01882 324057019070 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 324057019071 metal binding site [ion binding]; metal-binding site 324057019072 dimer interface [polypeptide binding]; other site 324057019073 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 324057019074 putative hydrolase; Provisional; Region: PRK11460 324057019075 Predicted esterase [General function prediction only]; Region: COG0400 324057019076 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 324057019077 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057019078 Zn binding site [ion binding]; other site 324057019079 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 324057019080 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 324057019081 Zn binding site [ion binding]; other site 324057019082 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324057019083 MarR family; Region: MarR; pfam01047 324057019084 MarR family; Region: MarR_2; cl17246 324057019085 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 324057019086 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 324057019087 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 324057019088 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 324057019089 Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316 324057019090 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 324057019091 Protein of unknown function (DUF1284); Region: DUF1284; pfam06935 324057019092 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 324057019093 DNA binding site [nucleotide binding] 324057019094 active site 324057019095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057019096 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057019097 putative substrate translocation pore; other site 324057019098 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 324057019099 NAD(P) binding site [chemical binding]; other site 324057019100 catalytic residues [active] 324057019101 YhhN-like protein; Region: YhhN; pfam07947 324057019102 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 324057019103 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324057019104 FeS/SAM binding site; other site 324057019105 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 324057019106 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 324057019107 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 324057019108 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324057019109 Soluble P-type ATPase [General function prediction only]; Region: COG4087 324057019110 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 324057019111 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 324057019112 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 324057019113 Ligand Binding Site [chemical binding]; other site 324057019114 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 324057019115 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 324057019116 Ligand Binding Site [chemical binding]; other site 324057019117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057019118 NADH(P)-binding; Region: NAD_binding_10; pfam13460 324057019119 NAD(P) binding site [chemical binding]; other site 324057019120 active site 324057019121 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 324057019122 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 324057019123 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 324057019124 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057019125 putative ligand binding residues [chemical binding]; other site 324057019126 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 324057019127 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057019128 ABC-ATPase subunit interface; other site 324057019129 dimer interface [polypeptide binding]; other site 324057019130 putative PBP binding regions; other site 324057019131 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 324057019132 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324057019133 ABC-ATPase subunit interface; other site 324057019134 dimer interface [polypeptide binding]; other site 324057019135 putative PBP binding regions; other site 324057019136 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 324057019137 FAD binding domain; Region: FAD_binding_2; pfam00890 324057019138 Predicted transcriptional regulator [Transcription]; Region: COG2378 324057019139 HTH domain; Region: HTH_11; pfam08279 324057019140 WYL domain; Region: WYL; pfam13280 324057019141 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 324057019142 Sulfatase; Region: Sulfatase; pfam00884 324057019143 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057019144 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057019145 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 324057019146 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 324057019147 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 324057019148 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 324057019149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057019150 putative substrate translocation pore; other site 324057019151 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 324057019152 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 324057019153 DNA binding residues [nucleotide binding] 324057019154 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 324057019155 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 324057019156 NADP binding site [chemical binding]; other site 324057019157 dimer interface [polypeptide binding]; other site 324057019158 Transcriptional regulators [Transcription]; Region: FadR; COG2186 324057019159 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057019160 DNA-binding site [nucleotide binding]; DNA binding site 324057019161 FCD domain; Region: FCD; pfam07729 324057019162 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 324057019163 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324057019164 substrate binding pocket [chemical binding]; other site 324057019165 membrane-bound complex binding site; other site 324057019166 hinge residues; other site 324057019167 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 324057019168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057019169 dimer interface [polypeptide binding]; other site 324057019170 conserved gate region; other site 324057019171 putative PBP binding loops; other site 324057019172 ABC-ATPase subunit interface; other site 324057019173 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 324057019174 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 324057019175 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 324057019176 Walker A/P-loop; other site 324057019177 ATP binding site [chemical binding]; other site 324057019178 Q-loop/lid; other site 324057019179 ABC transporter signature motif; other site 324057019180 Walker B; other site 324057019181 D-loop; other site 324057019182 H-loop/switch region; other site 324057019183 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 324057019184 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 324057019185 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 324057019186 active site 324057019187 ATP binding site [chemical binding]; other site 324057019188 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057019189 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 324057019190 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324057019191 short chain dehydrogenase; Provisional; Region: PRK06180 324057019192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324057019193 NAD(P) binding site [chemical binding]; other site 324057019194 active site 324057019195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057019196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057019197 HSP90 family protein; Provisional; Region: PRK14083 324057019198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057019199 ATP binding site [chemical binding]; other site 324057019200 Mg2+ binding site [ion binding]; other site 324057019201 G-X-G motif; other site 324057019202 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 324057019203 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 324057019204 dimerization interface [polypeptide binding]; other site 324057019205 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 324057019206 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057019207 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057019208 dimer interface [polypeptide binding]; other site 324057019209 phosphorylation site [posttranslational modification] 324057019210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057019211 ATP binding site [chemical binding]; other site 324057019212 Mg2+ binding site [ion binding]; other site 324057019213 G-X-G motif; other site 324057019214 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057019215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057019216 active site 324057019217 phosphorylation site [posttranslational modification] 324057019218 intermolecular recognition site; other site 324057019219 dimerization interface [polypeptide binding]; other site 324057019220 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057019221 DNA binding site [nucleotide binding] 324057019222 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 324057019223 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 324057019224 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057019225 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057019226 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 324057019227 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 324057019228 Phosphotransferase enzyme family; Region: APH; pfam01636 324057019229 active site 324057019230 ATP binding site [chemical binding]; other site 324057019231 substrate binding site [chemical binding]; other site 324057019232 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 324057019233 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 324057019234 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 324057019235 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 324057019236 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 324057019237 catalytic residues [active] 324057019238 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 324057019239 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 324057019240 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 324057019241 S-layer homology domain; Region: SLH; pfam00395 324057019242 S-layer homology domain; Region: SLH; pfam00395 324057019243 S-layer homology domain; Region: SLH; pfam00395 324057019244 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 324057019245 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 324057019246 Phosphotransferase enzyme family; Region: APH; pfam01636 324057019247 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 324057019248 active site 324057019249 substrate binding site [chemical binding]; other site 324057019250 ATP binding site [chemical binding]; other site 324057019251 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 324057019252 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 324057019253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057019254 putative substrate translocation pore; other site 324057019255 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 324057019256 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057019257 putative active site [active] 324057019258 heme pocket [chemical binding]; other site 324057019259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057019260 dimer interface [polypeptide binding]; other site 324057019261 phosphorylation site [posttranslational modification] 324057019262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057019263 ATP binding site [chemical binding]; other site 324057019264 Mg2+ binding site [ion binding]; other site 324057019265 G-X-G motif; other site 324057019266 PAS domain S-box; Region: sensory_box; TIGR00229 324057019267 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 324057019268 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 324057019269 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057019270 metal binding site [ion binding]; metal-binding site 324057019271 active site 324057019272 I-site; other site 324057019273 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324057019274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057019275 S-adenosylmethionine binding site [chemical binding]; other site 324057019276 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 324057019277 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057019278 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 324057019279 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057019280 classical (c) SDRs; Region: SDR_c; cd05233 324057019281 NAD(P) binding site [chemical binding]; other site 324057019282 active site 324057019283 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057019284 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057019285 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057019286 dimerization interface [polypeptide binding]; other site 324057019287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057019288 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057019289 putative substrate translocation pore; other site 324057019290 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057019291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057019292 active site 324057019293 phosphorylation site [posttranslational modification] 324057019294 intermolecular recognition site; other site 324057019295 dimerization interface [polypeptide binding]; other site 324057019296 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057019297 DNA binding site [nucleotide binding] 324057019298 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057019299 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 324057019300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057019301 ATP binding site [chemical binding]; other site 324057019302 Mg2+ binding site [ion binding]; other site 324057019303 G-X-G motif; other site 324057019304 FtsX-like permease family; Region: FtsX; pfam02687 324057019305 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324057019306 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 324057019307 Walker A/P-loop; other site 324057019308 ATP binding site [chemical binding]; other site 324057019309 Q-loop/lid; other site 324057019310 ABC transporter signature motif; other site 324057019311 Walker B; other site 324057019312 D-loop; other site 324057019313 H-loop/switch region; other site 324057019314 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 324057019315 active site 324057019316 catalytic triad [active] 324057019317 oxyanion hole [active] 324057019318 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 324057019319 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 324057019320 intersubunit interface [polypeptide binding]; other site 324057019321 active site 324057019322 zinc binding site [ion binding]; other site 324057019323 Na+ binding site [ion binding]; other site 324057019324 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 324057019325 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 324057019326 nucleotide binding site [chemical binding]; other site 324057019327 putative NEF/HSP70 interaction site [polypeptide binding]; other site 324057019328 SBD interface [polypeptide binding]; other site 324057019329 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 324057019330 HSP70 interaction site [polypeptide binding]; other site 324057019331 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057019332 binding surface 324057019333 TPR motif; other site 324057019334 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057019335 binding surface 324057019336 TPR motif; other site 324057019337 Tetratricopeptide repeat; Region: TPR_16; pfam13432 324057019338 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057019339 TPR motif; other site 324057019340 TPR repeat; Region: TPR_11; pfam13414 324057019341 binding surface 324057019342 TPR repeat; Region: TPR_11; pfam13414 324057019343 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057019344 binding surface 324057019345 TPR motif; other site 324057019346 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 324057019347 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057019348 binding surface 324057019349 TPR motif; other site 324057019350 TPR repeat; Region: TPR_11; pfam13414 324057019351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324057019352 TPR motif; other site 324057019353 binding surface 324057019354 Predicted membrane protein [Function unknown]; Region: COG1511 324057019355 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 324057019356 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 324057019357 S-layer homology domain; Region: SLH; pfam00395 324057019358 S-layer homology domain; Region: SLH; pfam00395 324057019359 S-layer homology domain; Region: SLH; pfam00395 324057019360 Transcriptional regulators [Transcription]; Region: GntR; COG1802 324057019361 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057019362 DNA-binding site [nucleotide binding]; DNA binding site 324057019363 FCD domain; Region: FCD; pfam07729 324057019364 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057019365 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 324057019366 active site 324057019367 metal binding site [ion binding]; metal-binding site 324057019368 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 324057019369 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 324057019370 active site 324057019371 metal binding site [ion binding]; metal-binding site 324057019372 hexamer interface [polypeptide binding]; other site 324057019373 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 324057019374 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 324057019375 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057019376 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 324057019377 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057019378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057019379 dimer interface [polypeptide binding]; other site 324057019380 conserved gate region; other site 324057019381 ABC-ATPase subunit interface; other site 324057019382 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057019383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057019384 dimer interface [polypeptide binding]; other site 324057019385 conserved gate region; other site 324057019386 putative PBP binding loops; other site 324057019387 ABC-ATPase subunit interface; other site 324057019388 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 324057019389 DHHW protein; Region: DHHW; pfam14286 324057019390 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 324057019391 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 324057019392 Predicted flavoprotein [General function prediction only]; Region: COG0431 324057019393 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 324057019394 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324057019395 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324057019396 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324057019397 dimerization interface [polypeptide binding]; other site 324057019398 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 324057019399 classical (c) SDRs; Region: SDR_c; cd05233 324057019400 NAD(P) binding site [chemical binding]; other site 324057019401 active site 324057019402 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 324057019403 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 324057019404 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 324057019405 Spore germination protein; Region: Spore_permease; cl17796 324057019406 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324057019407 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 324057019408 conserved repeat domain; Region: B_ant_repeat; TIGR01451 324057019409 conserved repeat domain; Region: B_ant_repeat; TIGR01451 324057019410 conserved repeat domain; Region: B_ant_repeat; TIGR01451 324057019411 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 324057019412 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 324057019413 putative active site [active] 324057019414 metal binding site [ion binding]; metal-binding site 324057019415 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 324057019416 putative hydrolase; Provisional; Region: PRK11460 324057019417 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057019418 non-specific DNA binding site [nucleotide binding]; other site 324057019419 salt bridge; other site 324057019420 sequence-specific DNA binding site [nucleotide binding]; other site 324057019421 Cupin domain; Region: Cupin_2; pfam07883 324057019422 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057019423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057019424 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 324057019425 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057019426 putative ligand binding residues [chemical binding]; other site 324057019427 metal-dependent hydrolase; Provisional; Region: PRK13291 324057019428 DinB superfamily; Region: DinB_2; pfam12867 324057019429 Protein of unknown function (DUF419); Region: DUF419; pfam04237 324057019430 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 324057019431 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 324057019432 putative hydrophobic ligand binding site [chemical binding]; other site 324057019433 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 324057019434 Coenzyme A binding pocket [chemical binding]; other site 324057019435 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 324057019436 putative hydrophobic ligand binding site [chemical binding]; other site 324057019437 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 324057019438 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324057019439 DNA binding residues [nucleotide binding] 324057019440 putative dimer interface [polypeptide binding]; other site 324057019441 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 324057019442 FtsX-like permease family; Region: FtsX; pfam02687 324057019443 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 324057019444 classical (c) SDRs; Region: SDR_c; cd05233 324057019445 NAD(P) binding site [chemical binding]; other site 324057019446 active site 324057019447 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 324057019448 classical (c) SDRs; Region: SDR_c; cd05233 324057019449 NAD(P) binding site [chemical binding]; other site 324057019450 active site 324057019451 Transcriptional regulators [Transcription]; Region: GntR; COG1802 324057019452 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057019453 DNA-binding site [nucleotide binding]; DNA binding site 324057019454 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324057019455 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324057019456 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 324057019457 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 324057019458 putative metal binding residues [ion binding]; other site 324057019459 signature motif; other site 324057019460 dimer interface [polypeptide binding]; other site 324057019461 active site 324057019462 polyP binding site; other site 324057019463 substrate binding site [chemical binding]; other site 324057019464 acceptor-phosphate pocket; other site 324057019465 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057019466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057019467 active site 324057019468 phosphorylation site [posttranslational modification] 324057019469 intermolecular recognition site; other site 324057019470 dimerization interface [polypeptide binding]; other site 324057019471 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057019472 DNA binding site [nucleotide binding] 324057019473 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057019474 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057019475 dimer interface [polypeptide binding]; other site 324057019476 phosphorylation site [posttranslational modification] 324057019477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057019478 ATP binding site [chemical binding]; other site 324057019479 Mg2+ binding site [ion binding]; other site 324057019480 G-X-G motif; other site 324057019481 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 324057019482 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 324057019483 Ligand binding site; other site 324057019484 Putative Catalytic site; other site 324057019485 DXD motif; other site 324057019486 Predicted membrane protein [Function unknown]; Region: COG2246 324057019487 GtrA-like protein; Region: GtrA; pfam04138 324057019488 short chain dehydrogenase; Provisional; Region: PRK06180 324057019489 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 324057019490 NADP binding site [chemical binding]; other site 324057019491 active site 324057019492 steroid binding site; other site 324057019493 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 324057019494 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057019495 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057019496 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057019497 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057019498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057019499 active site 324057019500 phosphorylation site [posttranslational modification] 324057019501 intermolecular recognition site; other site 324057019502 dimerization interface [polypeptide binding]; other site 324057019503 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057019504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057019505 ATP binding site [chemical binding]; other site 324057019506 Mg2+ binding site [ion binding]; other site 324057019507 G-X-G motif; other site 324057019508 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057019509 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057019510 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057019511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057019512 dimer interface [polypeptide binding]; other site 324057019513 ABC-ATPase subunit interface; other site 324057019514 putative PBP binding loops; other site 324057019515 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057019516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057019517 dimer interface [polypeptide binding]; other site 324057019518 conserved gate region; other site 324057019519 putative PBP binding loops; other site 324057019520 ABC-ATPase subunit interface; other site 324057019521 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 324057019522 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 324057019523 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324057019524 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 324057019525 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 324057019526 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 324057019527 metal binding site [ion binding]; metal-binding site 324057019528 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 324057019529 active site flap/lid [active] 324057019530 nucleophilic elbow; other site 324057019531 catalytic triad [active] 324057019532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 324057019533 Chitin binding domain; Region: Chitin_bind_3; pfam03067 324057019534 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057019535 Interdomain contacts; other site 324057019536 Cytokine receptor motif; other site 324057019537 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 324057019538 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324057019539 Interdomain contacts; other site 324057019540 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 324057019541 aromatic chitin/cellulose binding site residues [chemical binding]; other site 324057019542 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 324057019543 aromatic chitin/cellulose binding site residues [chemical binding]; other site 324057019544 Predicted transcriptional regulator [Transcription]; Region: COG2378 324057019545 HTH domain; Region: HTH_11; pfam08279 324057019546 WYL domain; Region: WYL; pfam13280 324057019547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057019548 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 324057019549 putative substrate translocation pore; other site 324057019550 Beta-lactamase; Region: Beta-lactamase; pfam00144 324057019551 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 324057019552 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 324057019553 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324057019554 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324057019555 Coenzyme A binding pocket [chemical binding]; other site 324057019556 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324057019557 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 324057019558 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057019559 PAS domain; Region: PAS_9; pfam13426 324057019560 putative active site [active] 324057019561 heme pocket [chemical binding]; other site 324057019562 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 324057019563 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 324057019564 dimer interface [polypeptide binding]; other site 324057019565 putative CheW interface [polypeptide binding]; other site 324057019566 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 324057019567 DNA binding residues [nucleotide binding] 324057019568 B12 binding domain; Region: B12-binding_2; pfam02607 324057019569 B12 binding domain; Region: B12-binding; pfam02310 324057019570 B12 binding site [chemical binding]; other site 324057019571 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 324057019572 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057019573 putative NAD(P) binding site [chemical binding]; other site 324057019574 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 324057019575 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 324057019576 DNA binding residues [nucleotide binding] 324057019577 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 324057019578 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 324057019579 G1 box; other site 324057019580 putative GEF interaction site [polypeptide binding]; other site 324057019581 GTP/Mg2+ binding site [chemical binding]; other site 324057019582 Switch I region; other site 324057019583 G2 box; other site 324057019584 G3 box; other site 324057019585 Switch II region; other site 324057019586 G4 box; other site 324057019587 G5 box; other site 324057019588 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 324057019589 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 324057019590 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 324057019591 MFS/sugar transport protein; Region: MFS_2; pfam13347 324057019592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057019593 putative substrate translocation pore; other site 324057019594 cytosine deaminase; Provisional; Region: PRK09230 324057019595 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 324057019596 active site 324057019597 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 324057019598 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 324057019599 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 324057019600 NMT1/THI5 like; Region: NMT1; pfam09084 324057019601 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 324057019602 cytosine deaminase; Provisional; Region: PRK05985 324057019603 active site 324057019604 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057019605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324057019606 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 324057019607 FAD binding domain; Region: FAD_binding_4; pfam01565 324057019608 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324057019609 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 324057019610 Walker A/P-loop; other site 324057019611 ATP binding site [chemical binding]; other site 324057019612 Q-loop/lid; other site 324057019613 ABC transporter signature motif; other site 324057019614 Walker B; other site 324057019615 D-loop; other site 324057019616 H-loop/switch region; other site 324057019617 Creatinine amidohydrolase; Region: Creatininase; pfam02633 324057019618 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324057019619 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324057019620 DNA-binding site [nucleotide binding]; DNA binding site 324057019621 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 324057019622 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 324057019623 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324057019624 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324057019625 non-specific DNA binding site [nucleotide binding]; other site 324057019626 salt bridge; other site 324057019627 sequence-specific DNA binding site [nucleotide binding]; other site 324057019628 Uncharacterized conserved protein [Function unknown]; Region: COG4925 324057019629 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 324057019630 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 324057019631 TIGR02452 family protein; Region: TIGR02452 324057019632 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 324057019633 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 324057019634 nudix motif; other site 324057019635 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 324057019636 nudix motif; other site 324057019637 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 324057019638 putative active site [active] 324057019639 nucleotide binding site [chemical binding]; other site 324057019640 nudix motif; other site 324057019641 putative metal binding site [ion binding]; other site 324057019642 seryl-tRNA synthetase; Provisional; Region: PRK05431 324057019643 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 324057019644 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 324057019645 dimer interface [polypeptide binding]; other site 324057019646 active site 324057019647 motif 1; other site 324057019648 motif 2; other site 324057019649 motif 3; other site 324057019650 Response regulator receiver domain; Region: Response_reg; pfam00072 324057019651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057019652 active site 324057019653 phosphorylation site [posttranslational modification] 324057019654 intermolecular recognition site; other site 324057019655 dimerization interface [polypeptide binding]; other site 324057019656 PAS domain S-box; Region: sensory_box; TIGR00229 324057019657 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057019658 putative active site [active] 324057019659 heme pocket [chemical binding]; other site 324057019660 PAS domain; Region: PAS_9; pfam13426 324057019661 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057019662 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057019663 dimer interface [polypeptide binding]; other site 324057019664 phosphorylation site [posttranslational modification] 324057019665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057019666 ATP binding site [chemical binding]; other site 324057019667 Mg2+ binding site [ion binding]; other site 324057019668 G-X-G motif; other site 324057019669 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 324057019670 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 324057019671 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 324057019672 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 324057019673 CHASE3 domain; Region: CHASE3; pfam05227 324057019674 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 324057019675 dimerization interface [polypeptide binding]; other site 324057019676 GAF domain; Region: GAF_2; pfam13185 324057019677 GAF domain; Region: GAF; pfam01590 324057019678 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 324057019679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057019680 ATP binding site [chemical binding]; other site 324057019681 Mg2+ binding site [ion binding]; other site 324057019682 G-X-G motif; other site 324057019683 Response regulator receiver domain; Region: Response_reg; pfam00072 324057019684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057019685 active site 324057019686 phosphorylation site [posttranslational modification] 324057019687 intermolecular recognition site; other site 324057019688 dimerization interface [polypeptide binding]; other site 324057019689 Uncharacterized conserved protein [Function unknown]; Region: COG2308 324057019690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 324057019691 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 324057019692 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 324057019693 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 324057019694 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 324057019695 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324057019696 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057019697 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057019698 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 324057019699 SnoaL-like domain; Region: SnoaL_3; pfam13474 324057019700 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057019701 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057019702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057019703 dimer interface [polypeptide binding]; other site 324057019704 conserved gate region; other site 324057019705 putative PBP binding loops; other site 324057019706 ABC-ATPase subunit interface; other site 324057019707 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057019708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057019709 dimer interface [polypeptide binding]; other site 324057019710 conserved gate region; other site 324057019711 ABC-ATPase subunit interface; other site 324057019712 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 324057019713 active site 324057019714 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 324057019715 N- and C-terminal domain interface [polypeptide binding]; other site 324057019716 D-xylulose kinase; Region: XylB; TIGR01312 324057019717 active site 324057019718 MgATP binding site [chemical binding]; other site 324057019719 catalytic site [active] 324057019720 metal binding site [ion binding]; metal-binding site 324057019721 xylulose binding site [chemical binding]; other site 324057019722 homodimer interface [polypeptide binding]; other site 324057019723 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324057019724 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 324057019725 nucleotide binding site [chemical binding]; other site 324057019726 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 324057019727 malate:quinone oxidoreductase; Validated; Region: PRK05257 324057019728 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 324057019729 Predicted transcriptional regulators [Transcription]; Region: COG1733 324057019730 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 324057019731 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 324057019732 NADH(P)-binding; Region: NAD_binding_10; pfam13460 324057019733 NAD binding site [chemical binding]; other site 324057019734 substrate binding site [chemical binding]; other site 324057019735 putative active site [active] 324057019736 long-chain fatty acyl-ACP reductase (aldehyde-forming); Region: AcACP_reductase; TIGR04058 324057019737 YCII-related domain; Region: YCII; cl00999 324057019738 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 324057019739 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 324057019740 NodB motif; other site 324057019741 active site 324057019742 catalytic site [active] 324057019743 metal binding site [ion binding]; metal-binding site 324057019744 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 324057019745 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057019746 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057019747 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057019748 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057019749 intersubunit interface [polypeptide binding]; other site 324057019750 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324057019751 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324057019752 intersubunit interface [polypeptide binding]; other site 324057019753 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 324057019754 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057019755 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324057019756 DNA binding residues [nucleotide binding] 324057019757 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 324057019758 active site 324057019759 putative catalytic site [active] 324057019760 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324057019761 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 324057019762 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 324057019763 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 324057019764 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 324057019765 A new structural DNA glycosylase; Region: AlkD_like; cd06561 324057019766 active site 324057019767 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 324057019768 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 324057019769 active site 324057019770 non-prolyl cis peptide bond; other site 324057019771 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057019772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057019773 dimer interface [polypeptide binding]; other site 324057019774 conserved gate region; other site 324057019775 putative PBP binding loops; other site 324057019776 ABC-ATPase subunit interface; other site 324057019777 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324057019778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057019779 dimer interface [polypeptide binding]; other site 324057019780 conserved gate region; other site 324057019781 putative PBP binding loops; other site 324057019782 ABC-ATPase subunit interface; other site 324057019783 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 324057019784 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324057019785 substrate binding pocket [chemical binding]; other site 324057019786 membrane-bound complex binding site; other site 324057019787 hinge residues; other site 324057019788 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324057019789 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 324057019790 Walker A/P-loop; other site 324057019791 ATP binding site [chemical binding]; other site 324057019792 Q-loop/lid; other site 324057019793 ABC transporter signature motif; other site 324057019794 Walker B; other site 324057019795 D-loop; other site 324057019796 H-loop/switch region; other site 324057019797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057019798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057019799 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324057019800 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 324057019801 NAD(P) binding site [chemical binding]; other site 324057019802 active site 324057019803 Predicted transcriptional regulators [Transcription]; Region: COG1733 324057019804 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 324057019805 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 324057019806 dimer interface [polypeptide binding]; other site 324057019807 FMN binding site [chemical binding]; other site 324057019808 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 324057019809 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057019810 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057019811 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 324057019812 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 324057019813 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 324057019814 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 324057019815 S-layer homology domain; Region: SLH; pfam00395 324057019816 S-layer homology domain; Region: SLH; pfam00395 324057019817 S-layer homology domain; Region: SLH; pfam00395 324057019818 Predicted transcriptional regulators [Transcription]; Region: COG1733 324057019819 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 324057019820 DoxX-like family; Region: DoxX_2; pfam13564 324057019821 short chain dehydrogenase; Provisional; Region: PRK06482 324057019822 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 324057019823 NADP binding site [chemical binding]; other site 324057019824 active site 324057019825 steroid binding site; other site 324057019826 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057019827 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057019828 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 324057019829 Phosphotransferase enzyme family; Region: APH; pfam01636 324057019830 putative active site [active] 324057019831 putative substrate binding site [chemical binding]; other site 324057019832 ATP binding site [chemical binding]; other site 324057019833 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 324057019834 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324057019835 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 324057019836 DoxX-like family; Region: DoxX_2; pfam13564 324057019837 Response regulator receiver domain; Region: Response_reg; pfam00072 324057019838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057019839 active site 324057019840 phosphorylation site [posttranslational modification] 324057019841 intermolecular recognition site; other site 324057019842 dimerization interface [polypeptide binding]; other site 324057019843 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057019844 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057019845 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057019846 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057019847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057019848 dimer interface [polypeptide binding]; other site 324057019849 conserved gate region; other site 324057019850 putative PBP binding loops; other site 324057019851 ABC-ATPase subunit interface; other site 324057019852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057019853 dimer interface [polypeptide binding]; other site 324057019854 conserved gate region; other site 324057019855 putative PBP binding loops; other site 324057019856 ABC-ATPase subunit interface; other site 324057019857 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057019858 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057019859 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324057019860 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057019861 dimerization interface [polypeptide binding]; other site 324057019862 Histidine kinase; Region: His_kinase; pfam06580 324057019863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057019864 ATP binding site [chemical binding]; other site 324057019865 Mg2+ binding site [ion binding]; other site 324057019866 G-X-G motif; other site 324057019867 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 324057019868 Class I aldolases; Region: Aldolase_Class_I; cl17187 324057019869 catalytic residue [active] 324057019870 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057019871 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057019872 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057019873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057019874 dimer interface [polypeptide binding]; other site 324057019875 ABC-ATPase subunit interface; other site 324057019876 putative PBP binding loops; other site 324057019877 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057019878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057019879 dimer interface [polypeptide binding]; other site 324057019880 conserved gate region; other site 324057019881 putative PBP binding loops; other site 324057019882 ABC-ATPase subunit interface; other site 324057019883 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 324057019884 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 324057019885 putative active site cavity [active] 324057019886 N-acetylmannosamine kinase; Provisional; Region: PRK05082 324057019887 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 324057019888 nucleotide binding site [chemical binding]; other site 324057019889 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 324057019890 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 324057019891 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 324057019892 putative active site [active] 324057019893 Domain of unknown function (DUF386); Region: DUF386; cl01047 324057019894 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324057019895 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324057019896 DNA binding residues [nucleotide binding] 324057019897 dimerization interface [polypeptide binding]; other site 324057019898 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 324057019899 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 324057019900 catalytic Zn binding site [ion binding]; other site 324057019901 NAD binding site [chemical binding]; other site 324057019902 structural Zn binding site [ion binding]; other site 324057019903 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057019904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057019905 putative substrate translocation pore; other site 324057019906 Predicted transcriptional regulator [Transcription]; Region: COG2378 324057019907 HTH domain; Region: HTH_11; pfam08279 324057019908 WYL domain; Region: WYL; pfam13280 324057019909 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 324057019910 classical (c) SDRs; Region: SDR_c; cd05233 324057019911 NAD(P) binding site [chemical binding]; other site 324057019912 active site 324057019913 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 324057019914 dimerization domain swap beta strand [polypeptide binding]; other site 324057019915 regulatory protein interface [polypeptide binding]; other site 324057019916 active site 324057019917 regulatory phosphorylation site [posttranslational modification]; other site 324057019918 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 324057019919 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 324057019920 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 324057019921 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 324057019922 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 324057019923 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 324057019924 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 324057019925 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 324057019926 active site 324057019927 phosphorylation site [posttranslational modification] 324057019928 HTH domain; Region: HTH_11; pfam08279 324057019929 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 324057019930 HTH domain; Region: HTH_11; cl17392 324057019931 PRD domain; Region: PRD; pfam00874 324057019932 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 324057019933 active site 324057019934 P-loop; other site 324057019935 phosphorylation site [posttranslational modification] 324057019936 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 324057019937 active site 324057019938 phosphorylation site [posttranslational modification] 324057019939 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 324057019940 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 324057019941 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 324057019942 active site 324057019943 P-loop; other site 324057019944 phosphorylation site [posttranslational modification] 324057019945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057019946 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324057019947 putative substrate translocation pore; other site 324057019948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324057019949 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324057019950 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324057019951 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 324057019952 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 324057019953 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324057019954 Double zinc ribbon; Region: DZR; pfam12773 324057019955 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 324057019956 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324057019957 Double zinc ribbon; Region: DZR; pfam12773 324057019958 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324057019959 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 324057019960 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 324057019961 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 324057019962 FAD binding domain; Region: FAD_binding_4; pfam01565 324057019963 Berberine and berberine like; Region: BBE; pfam08031 324057019964 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 324057019965 putative catalytic site [active] 324057019966 putative metal binding site [ion binding]; other site 324057019967 putative phosphate binding site [ion binding]; other site 324057019968 GAF domain; Region: GAF; pfam01590 324057019969 GAF domain; Region: GAF_2; pfam13185 324057019970 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 324057019971 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324057019972 metal binding site [ion binding]; metal-binding site 324057019973 active site 324057019974 I-site; other site 324057019975 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057019976 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057019977 Response regulator receiver domain; Region: Response_reg; pfam00072 324057019978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057019979 active site 324057019980 phosphorylation site [posttranslational modification] 324057019981 intermolecular recognition site; other site 324057019982 dimerization interface [polypeptide binding]; other site 324057019983 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324057019984 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324057019985 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 324057019986 Histidine kinase; Region: His_kinase; pfam06580 324057019987 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 324057019988 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324057019989 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324057019990 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 324057019991 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324057019992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057019993 dimer interface [polypeptide binding]; other site 324057019994 ABC-ATPase subunit interface; other site 324057019995 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 324057019996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324057019997 dimer interface [polypeptide binding]; other site 324057019998 conserved gate region; other site 324057019999 putative PBP binding loops; other site 324057020000 ABC-ATPase subunit interface; other site 324057020001 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 324057020002 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 324057020003 Ankyrin repeat; Region: Ank; pfam00023 324057020004 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 324057020005 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 324057020006 YyzF-like protein; Region: YyzF; pfam14116 324057020007 hypothetical protein; Provisional; Region: PRK02237 324057020008 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 324057020009 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 324057020010 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 324057020011 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 324057020012 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 324057020013 Penicillinase repressor; Region: Pencillinase_R; cl17580 324057020014 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 324057020015 YycH protein; Region: YycI; cl02015 324057020016 YycH protein; Region: YycH; pfam07435 324057020017 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 324057020018 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324057020019 dimerization interface [polypeptide binding]; other site 324057020020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324057020021 putative active site [active] 324057020022 heme pocket [chemical binding]; other site 324057020023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324057020024 dimer interface [polypeptide binding]; other site 324057020025 phosphorylation site [posttranslational modification] 324057020026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324057020027 ATP binding site [chemical binding]; other site 324057020028 Mg2+ binding site [ion binding]; other site 324057020029 G-X-G motif; other site 324057020030 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324057020031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324057020032 active site 324057020033 phosphorylation site [posttranslational modification] 324057020034 intermolecular recognition site; other site 324057020035 dimerization interface [polypeptide binding]; other site 324057020036 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324057020037 DNA binding site [nucleotide binding] 324057020038 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 324057020039 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324057020040 G5 domain; Region: G5; pfam07501 324057020041 Peptidase family M23; Region: Peptidase_M23; pfam01551 324057020042 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 324057020043 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 324057020044 GDP-binding site [chemical binding]; other site 324057020045 ACT binding site; other site 324057020046 IMP binding site; other site 324057020047 replicative DNA helicase; Provisional; Region: PRK05748 324057020048 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 324057020049 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 324057020050 Walker A motif; other site 324057020051 ATP binding site [chemical binding]; other site 324057020052 Walker B motif; other site 324057020053 DNA binding loops [nucleotide binding] 324057020054 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 324057020055 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 324057020056 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 324057020057 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 324057020058 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 324057020059 DHH family; Region: DHH; pfam01368 324057020060 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 324057020061 D-glutamate deacylase; Validated; Region: PRK09061 324057020062 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324057020063 active site 324057020064 FOG: CBS domain [General function prediction only]; Region: COG0517 324057020065 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 324057020066 Predicted membrane protein [Function unknown]; Region: COG4818 324057020067 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 324057020068 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 324057020069 Domain of unknown function DUF21; Region: DUF21; pfam01595 324057020070 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 324057020071 Transporter associated domain; Region: CorC_HlyC; smart01091 324057020072 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 324057020073 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 324057020074 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 324057020075 Uncharacterized conserved protein [Function unknown]; Region: COG2427 324057020076 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 324057020077 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 324057020078 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 324057020079 dimer interface [polypeptide binding]; other site 324057020080 ssDNA binding site [nucleotide binding]; other site 324057020081 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324057020082 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 324057020083 YjzC-like protein; Region: YjzC; pfam14168 324057020084 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 324057020085 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 324057020086 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 324057020087 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 324057020088 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 324057020089 Mechanosensitive ion channel; Region: MS_channel; pfam00924 324057020090 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 324057020091 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 324057020092 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 324057020093 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 324057020094 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324057020095 catalytic residue [active] 324057020096 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 324057020097 ParB-like nuclease domain; Region: ParB; smart00470 324057020098 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 324057020099 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 324057020100 P-loop; other site 324057020101 Magnesium ion binding site [ion binding]; other site 324057020102 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 324057020103 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 324057020104 ParB-like nuclease domain; Region: ParB; smart00470 324057020105 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 324057020106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324057020107 S-adenosylmethionine binding site [chemical binding]; other site 324057020108 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 324057020109 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 324057020110 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 324057020111 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 324057020112 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 324057020113 trmE is a tRNA modification GTPase; Region: trmE; cd04164 324057020114 G1 box; other site 324057020115 GTP/Mg2+ binding site [chemical binding]; other site 324057020116 Switch I region; other site 324057020117 G2 box; other site 324057020118 Switch II region; other site 324057020119 G3 box; other site 324057020120 G4 box; other site 324057020121 G5 box; other site 324057020122 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 324057020123 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 324057020124 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 324057020125 G-X-X-G motif; other site 324057020126 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 324057020127 RxxxH motif; other site 324057020128 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 324057020129 ribonuclease P; Reviewed; Region: rnpA; PRK00499 324057020130 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399