-- dump date 20140619_230233 -- class Genbank::misc_feature -- table misc_feature_note -- id note 481743000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 481743000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 481743000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743000004 Walker A motif; other site 481743000005 ATP binding site [chemical binding]; other site 481743000006 Walker B motif; other site 481743000007 arginine finger; other site 481743000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 481743000009 DnaA box-binding interface [nucleotide binding]; other site 481743000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 481743000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 481743000012 putative DNA binding surface [nucleotide binding]; other site 481743000013 dimer interface [polypeptide binding]; other site 481743000014 beta-clamp/clamp loader binding surface; other site 481743000015 beta-clamp/translesion DNA polymerase binding surface; other site 481743000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 481743000017 RNA binding surface [nucleotide binding]; other site 481743000018 recombination protein F; Reviewed; Region: recF; PRK00064 481743000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 481743000020 Walker A/P-loop; other site 481743000021 ATP binding site [chemical binding]; other site 481743000022 Q-loop/lid; other site 481743000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743000024 ABC transporter signature motif; other site 481743000025 Walker B; other site 481743000026 D-loop; other site 481743000027 H-loop/switch region; other site 481743000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 481743000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743000030 Mg2+ binding site [ion binding]; other site 481743000031 G-X-G motif; other site 481743000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 481743000033 anchoring element; other site 481743000034 dimer interface [polypeptide binding]; other site 481743000035 ATP binding site [chemical binding]; other site 481743000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 481743000037 active site 481743000038 putative metal-binding site [ion binding]; other site 481743000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 481743000040 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 481743000041 DNA gyrase subunit A; Validated; Region: PRK05560 481743000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 481743000043 CAP-like domain; other site 481743000044 active site 481743000045 primary dimer interface [polypeptide binding]; other site 481743000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 481743000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 481743000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 481743000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 481743000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 481743000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 481743000052 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 481743000053 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 481743000054 Zn2+ binding site [ion binding]; other site 481743000055 Mg2+ binding site [ion binding]; other site 481743000056 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 481743000057 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 481743000058 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 481743000059 homodimer interface [polypeptide binding]; other site 481743000060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743000061 catalytic residue [active] 481743000062 thymidylate kinase; Validated; Region: tmk; PRK00698 481743000063 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 481743000064 TMP-binding site; other site 481743000065 ATP-binding site [chemical binding]; other site 481743000066 Protein of unknown function (DUF970); Region: DUF970; pfam06153 481743000067 Protein of unknown function (DUF327); Region: DUF327; pfam03885 481743000068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 481743000069 DNA polymerase III subunit delta'; Validated; Region: PRK08058 481743000070 Walker A motif; other site 481743000071 ATP binding site [chemical binding]; other site 481743000072 DNA polymerase III subunit delta'; Validated; Region: PRK08485 481743000073 Walker B motif; other site 481743000074 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 481743000075 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 481743000076 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 481743000077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743000078 S-adenosylmethionine binding site [chemical binding]; other site 481743000079 Predicted methyltransferases [General function prediction only]; Region: COG0313 481743000080 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 481743000081 putative SAM binding site [chemical binding]; other site 481743000082 putative homodimer interface [polypeptide binding]; other site 481743000083 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 481743000084 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 481743000085 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 481743000086 Zn2+ binding site [ion binding]; other site 481743000087 Mg2+ binding site [ion binding]; other site 481743000088 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 481743000089 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 481743000090 active site 481743000091 Domain of unknown function (DUF348); Region: DUF348; pfam03990 481743000092 Domain of unknown function (DUF348); Region: DUF348; pfam03990 481743000093 G5 domain; Region: G5; pfam07501 481743000094 3D domain; Region: 3D; cl01439 481743000095 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 481743000096 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 481743000097 putative active site [active] 481743000098 putative metal binding site [ion binding]; other site 481743000099 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 481743000100 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 481743000101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743000102 S-adenosylmethionine binding site [chemical binding]; other site 481743000103 YabG peptidase U57; Region: Peptidase_U57; cl05250 481743000104 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 481743000105 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 481743000106 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 481743000107 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 481743000108 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 481743000109 pur operon repressor; Provisional; Region: PRK09213 481743000110 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 481743000111 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 481743000112 active site 481743000113 regulatory protein SpoVG; Reviewed; Region: PRK13259 481743000114 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 481743000115 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 481743000116 Substrate binding site; other site 481743000117 Mg++ binding site; other site 481743000118 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 481743000119 active site 481743000120 substrate binding site [chemical binding]; other site 481743000121 CoA binding site [chemical binding]; other site 481743000122 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 481743000123 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 481743000124 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 481743000125 active site 481743000126 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 481743000127 putative active site [active] 481743000128 catalytic residue [active] 481743000129 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 481743000130 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 481743000131 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 481743000132 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481743000133 ATP binding site [chemical binding]; other site 481743000134 putative Mg++ binding site [ion binding]; other site 481743000135 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481743000136 nucleotide binding region [chemical binding]; other site 481743000137 ATP-binding site [chemical binding]; other site 481743000138 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 481743000139 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 481743000140 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 481743000141 stage V sporulation protein T; Region: spore_V_T; TIGR02851 481743000142 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 481743000143 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 481743000144 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 481743000145 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 481743000146 putative SAM binding site [chemical binding]; other site 481743000147 putative homodimer interface [polypeptide binding]; other site 481743000148 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 481743000149 homodimer interface [polypeptide binding]; other site 481743000150 metal binding site [ion binding]; metal-binding site 481743000151 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 481743000152 homodimer interface [polypeptide binding]; other site 481743000153 active site 481743000154 putative chemical substrate binding site [chemical binding]; other site 481743000155 metal binding site [ion binding]; metal-binding site 481743000156 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 481743000157 IHF dimer interface [polypeptide binding]; other site 481743000158 IHF - DNA interface [nucleotide binding]; other site 481743000159 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 481743000160 RNA binding surface [nucleotide binding]; other site 481743000161 YabP family; Region: YabP; cl06766 481743000162 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 481743000163 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 481743000164 Septum formation initiator; Region: DivIC; pfam04977 481743000165 hypothetical protein; Provisional; Region: PRK08582 481743000166 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 481743000167 RNA binding site [nucleotide binding]; other site 481743000168 ABC-2 type transporter; Region: ABC2_membrane; cl17235 481743000169 stage II sporulation protein E; Region: spore_II_E; TIGR02865 481743000170 Cation transport protein; Region: TrkH; cl17365 481743000171 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 481743000172 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 481743000173 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 481743000174 metal ion-dependent adhesion site (MIDAS); other site 481743000175 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 481743000176 active site 481743000177 ATP binding site [chemical binding]; other site 481743000178 substrate binding site [chemical binding]; other site 481743000179 activation loop (A-loop); other site 481743000180 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 481743000181 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 481743000182 Ligand Binding Site [chemical binding]; other site 481743000183 TilS substrate C-terminal domain; Region: TilS_C; smart00977 481743000184 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 481743000185 active site 481743000186 FtsH Extracellular; Region: FtsH_ext; pfam06480 481743000187 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 481743000188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743000189 Walker A motif; other site 481743000190 ATP binding site [chemical binding]; other site 481743000191 Walker B motif; other site 481743000192 arginine finger; other site 481743000193 Peptidase family M41; Region: Peptidase_M41; pfam01434 481743000194 Quinolinate synthetase A protein; Region: NadA; pfam02445 481743000195 L-aspartate oxidase; Provisional; Region: PRK06175 481743000196 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 481743000197 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 481743000198 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 481743000199 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 481743000200 dimerization interface [polypeptide binding]; other site 481743000201 active site 481743000202 pantothenate kinase; Reviewed; Region: PRK13318 481743000203 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 481743000204 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 481743000205 dimerization interface [polypeptide binding]; other site 481743000206 domain crossover interface; other site 481743000207 redox-dependent activation switch; other site 481743000208 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 481743000209 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 481743000210 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 481743000211 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 481743000212 dimer interface [polypeptide binding]; other site 481743000213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743000214 catalytic residue [active] 481743000215 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 481743000216 anthranilate synthase component I; Region: PLN02445 481743000217 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 481743000218 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 481743000219 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 481743000220 glutamine binding [chemical binding]; other site 481743000221 catalytic triad [active] 481743000222 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 481743000223 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 481743000224 homodimer interface [polypeptide binding]; other site 481743000225 substrate-cofactor binding pocket; other site 481743000226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743000227 catalytic residue [active] 481743000228 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 481743000229 dihydropteroate synthase; Region: DHPS; TIGR01496 481743000230 substrate binding pocket [chemical binding]; other site 481743000231 dimer interface [polypeptide binding]; other site 481743000232 inhibitor binding site; inhibition site 481743000233 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 481743000234 homooctamer interface [polypeptide binding]; other site 481743000235 active site 481743000236 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 481743000237 catalytic center binding site [active] 481743000238 ATP binding site [chemical binding]; other site 481743000239 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481743000240 non-specific DNA binding site [nucleotide binding]; other site 481743000241 salt bridge; other site 481743000242 sequence-specific DNA binding site [nucleotide binding]; other site 481743000243 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 481743000244 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 481743000245 FMN binding site [chemical binding]; other site 481743000246 active site 481743000247 catalytic residues [active] 481743000248 substrate binding site [chemical binding]; other site 481743000249 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 481743000250 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 481743000251 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 481743000252 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 481743000253 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 481743000254 dimer interface [polypeptide binding]; other site 481743000255 putative anticodon binding site; other site 481743000256 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 481743000257 motif 1; other site 481743000258 active site 481743000259 motif 2; other site 481743000260 motif 3; other site 481743000261 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 481743000262 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 481743000263 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 481743000264 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 481743000265 active site 481743000266 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 481743000267 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 481743000268 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 481743000269 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 481743000270 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 481743000271 active site 481743000272 multimer interface [polypeptide binding]; other site 481743000273 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 481743000274 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 481743000275 predicted active site [active] 481743000276 catalytic triad [active] 481743000277 seryl-tRNA synthetase; Provisional; Region: PRK05431 481743000278 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 481743000279 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 481743000280 dimer interface [polypeptide binding]; other site 481743000281 active site 481743000282 motif 1; other site 481743000283 motif 2; other site 481743000284 motif 3; other site 481743000285 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 481743000286 nucleoside/Zn binding site; other site 481743000287 dimer interface [polypeptide binding]; other site 481743000288 catalytic motif [active] 481743000289 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 481743000290 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743000291 dimerization interface [polypeptide binding]; other site 481743000292 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481743000293 putative active site [active] 481743000294 heme pocket [chemical binding]; other site 481743000295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743000296 dimer interface [polypeptide binding]; other site 481743000297 phosphorylation site [posttranslational modification] 481743000298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743000299 ATP binding site [chemical binding]; other site 481743000300 Mg2+ binding site [ion binding]; other site 481743000301 G-X-G motif; other site 481743000302 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 481743000303 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 481743000304 RNA binding surface [nucleotide binding]; other site 481743000305 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 481743000306 probable active site [active] 481743000307 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 481743000308 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 481743000309 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 481743000310 ligand binding site [chemical binding]; other site 481743000311 flagellar motor protein MotA; Validated; Region: PRK08124 481743000312 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 481743000313 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 481743000314 aromatic arch; other site 481743000315 DCoH dimer interaction site [polypeptide binding]; other site 481743000316 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 481743000317 DCoH tetramer interaction site [polypeptide binding]; other site 481743000318 substrate binding site [chemical binding]; other site 481743000319 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 481743000320 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 481743000321 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 481743000322 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 481743000323 NlpC/P60 family; Region: NLPC_P60; pfam00877 481743000324 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 481743000325 Zn binding site [ion binding]; other site 481743000326 YwhD family; Region: YwhD; pfam08741 481743000327 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743000328 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 481743000329 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 481743000330 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743000331 dimerization interface [polypeptide binding]; other site 481743000332 putative DNA binding site [nucleotide binding]; other site 481743000333 putative Zn2+ binding site [ion binding]; other site 481743000334 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 481743000335 Transglycosylase; Region: Transgly; pfam00912 481743000336 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 481743000337 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 481743000338 spermidine synthase; Provisional; Region: PRK00811 481743000339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743000340 agmatinase; Region: agmatinase; TIGR01230 481743000341 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 481743000342 putative active site [active] 481743000343 Mn binding site [ion binding]; other site 481743000344 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 481743000345 putative hydrophobic ligand binding site [chemical binding]; other site 481743000346 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743000347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743000348 dimer interface [polypeptide binding]; other site 481743000349 conserved gate region; other site 481743000350 putative PBP binding loops; other site 481743000351 ABC-ATPase subunit interface; other site 481743000352 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743000353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743000354 dimer interface [polypeptide binding]; other site 481743000355 conserved gate region; other site 481743000356 putative PBP binding loops; other site 481743000357 ABC-ATPase subunit interface; other site 481743000358 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743000359 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743000360 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743000361 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743000362 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 481743000363 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743000364 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743000365 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 481743000366 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 481743000367 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 481743000368 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 481743000369 Beta-lactamase; Region: Beta-lactamase; pfam00144 481743000370 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 481743000371 active site 481743000372 Predicted amidohydrolase [General function prediction only]; Region: COG0388 481743000373 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 481743000374 putative active site [active] 481743000375 catalytic triad [active] 481743000376 putative dimer interface [polypeptide binding]; other site 481743000377 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 481743000378 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743000379 Coenzyme A binding pocket [chemical binding]; other site 481743000380 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 481743000381 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 481743000382 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 481743000383 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 481743000384 active site 481743000385 HIGH motif; other site 481743000386 KMSK motif region; other site 481743000387 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 481743000388 tRNA binding surface [nucleotide binding]; other site 481743000389 anticodon binding site; other site 481743000390 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 481743000391 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 481743000392 active site 481743000393 catalytic residues [active] 481743000394 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 481743000395 CTP synthetase; Validated; Region: pyrG; PRK05380 481743000396 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 481743000397 Catalytic site [active] 481743000398 active site 481743000399 UTP binding site [chemical binding]; other site 481743000400 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 481743000401 active site 481743000402 putative oxyanion hole; other site 481743000403 catalytic triad [active] 481743000404 Response regulator receiver domain; Region: Response_reg; pfam00072 481743000405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743000406 active site 481743000407 phosphorylation site [posttranslational modification] 481743000408 intermolecular recognition site; other site 481743000409 dimerization interface [polypeptide binding]; other site 481743000410 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 481743000411 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 481743000412 intersubunit interface [polypeptide binding]; other site 481743000413 active site 481743000414 zinc binding site [ion binding]; other site 481743000415 Na+ binding site [ion binding]; other site 481743000416 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 481743000417 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 481743000418 hinge; other site 481743000419 active site 481743000420 transcription termination factor Rho; Provisional; Region: rho; PRK09376 481743000421 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 481743000422 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 481743000423 RNA binding site [nucleotide binding]; other site 481743000424 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 481743000425 multimer interface [polypeptide binding]; other site 481743000426 Walker A motif; other site 481743000427 ATP binding site [chemical binding]; other site 481743000428 Walker B motif; other site 481743000429 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743000430 Radical SAM superfamily; Region: Radical_SAM; pfam04055 481743000431 FeS/SAM binding site; other site 481743000432 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 481743000433 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 481743000434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743000435 Walker A motif; other site 481743000436 ATP binding site [chemical binding]; other site 481743000437 Walker B motif; other site 481743000438 arginine finger; other site 481743000439 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 481743000440 hypothetical protein; Validated; Region: PRK00153 481743000441 recombination protein RecR; Reviewed; Region: recR; PRK00076 481743000442 RecR protein; Region: RecR; pfam02132 481743000443 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 481743000444 putative active site [active] 481743000445 putative metal-binding site [ion binding]; other site 481743000446 tetramer interface [polypeptide binding]; other site 481743000447 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 481743000448 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 481743000449 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 481743000450 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 481743000451 Walker A/P-loop; other site 481743000452 ATP binding site [chemical binding]; other site 481743000453 Q-loop/lid; other site 481743000454 ABC transporter signature motif; other site 481743000455 Walker B; other site 481743000456 D-loop; other site 481743000457 H-loop/switch region; other site 481743000458 TOBE domain; Region: TOBE; pfam03459 481743000459 HPr kinase/phosphorylase; Provisional; Region: PRK05428 481743000460 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 481743000461 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 481743000462 Hpr binding site; other site 481743000463 active site 481743000464 homohexamer subunit interaction site [polypeptide binding]; other site 481743000465 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 481743000466 pyrophosphatase PpaX; Provisional; Region: PRK13288 481743000467 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743000468 motif II; other site 481743000469 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 481743000470 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 481743000471 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 481743000472 trimer interface [polypeptide binding]; other site 481743000473 active site 481743000474 substrate binding site [chemical binding]; other site 481743000475 CoA binding site [chemical binding]; other site 481743000476 Acyltransferase family; Region: Acyl_transf_3; pfam01757 481743000477 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 481743000478 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 481743000479 dimer interface [polypeptide binding]; other site 481743000480 motif 1; other site 481743000481 active site 481743000482 motif 2; other site 481743000483 motif 3; other site 481743000484 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 481743000485 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 481743000486 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 481743000487 histidinol dehydrogenase; Region: hisD; TIGR00069 481743000488 NAD binding site [chemical binding]; other site 481743000489 dimerization interface [polypeptide binding]; other site 481743000490 product binding site; other site 481743000491 substrate binding site [chemical binding]; other site 481743000492 zinc binding site [ion binding]; other site 481743000493 catalytic residues [active] 481743000494 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 481743000495 putative active site pocket [active] 481743000496 4-fold oligomerization interface [polypeptide binding]; other site 481743000497 metal binding residues [ion binding]; metal-binding site 481743000498 3-fold/trimer interface [polypeptide binding]; other site 481743000499 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 481743000500 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 481743000501 putative active site [active] 481743000502 oxyanion strand; other site 481743000503 catalytic triad [active] 481743000504 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 481743000505 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 481743000506 catalytic residues [active] 481743000507 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 481743000508 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 481743000509 substrate binding site [chemical binding]; other site 481743000510 glutamase interaction surface [polypeptide binding]; other site 481743000511 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 481743000512 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 481743000513 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 481743000514 metal binding site [ion binding]; metal-binding site 481743000515 histidinol-phosphatase; Provisional; Region: PRK07328 481743000516 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 481743000517 active site 481743000518 dimer interface [polypeptide binding]; other site 481743000519 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 481743000520 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 481743000521 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 481743000522 active site 481743000523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743000524 TPR motif; other site 481743000525 binding surface 481743000526 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743000527 TPR motif; other site 481743000528 binding surface 481743000529 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 481743000530 binding surface 481743000531 TPR motif; other site 481743000532 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 481743000533 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 481743000534 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481743000535 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 481743000536 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743000537 Coenzyme A binding pocket [chemical binding]; other site 481743000538 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 481743000539 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481743000540 non-specific DNA binding site [nucleotide binding]; other site 481743000541 salt bridge; other site 481743000542 sequence-specific DNA binding site [nucleotide binding]; other site 481743000543 tellurite resistance protein TehB; Provisional; Region: PRK12335 481743000544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743000545 S-adenosylmethionine binding site [chemical binding]; other site 481743000546 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 481743000547 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 481743000548 active site 481743000549 Phosphotransferase enzyme family; Region: APH; pfam01636 481743000550 ATP binding site [chemical binding]; other site 481743000551 antibiotic binding site [chemical binding]; other site 481743000552 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 481743000553 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743000554 Coenzyme A binding pocket [chemical binding]; other site 481743000555 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 481743000556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743000557 Coenzyme A binding pocket [chemical binding]; other site 481743000558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 481743000559 RDD family; Region: RDD; pfam06271 481743000560 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 481743000561 nudix motif; other site 481743000562 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 481743000563 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 481743000564 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 481743000565 Beta-lactamase; Region: Beta-lactamase; pfam00144 481743000566 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743000567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743000568 active site 481743000569 phosphorylation site [posttranslational modification] 481743000570 intermolecular recognition site; other site 481743000571 dimerization interface [polypeptide binding]; other site 481743000572 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743000573 DNA binding residues [nucleotide binding] 481743000574 dimerization interface [polypeptide binding]; other site 481743000575 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 481743000576 Histidine kinase; Region: HisKA_3; pfam07730 481743000577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743000578 ATP binding site [chemical binding]; other site 481743000579 Mg2+ binding site [ion binding]; other site 481743000580 G-X-G motif; other site 481743000581 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 481743000582 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 481743000583 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743000584 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481743000585 Walker A/P-loop; other site 481743000586 ATP binding site [chemical binding]; other site 481743000587 Q-loop/lid; other site 481743000588 ABC transporter signature motif; other site 481743000589 Walker B; other site 481743000590 D-loop; other site 481743000591 H-loop/switch region; other site 481743000592 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 481743000593 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 481743000594 nucleotide binding site [chemical binding]; other site 481743000595 Butyrate kinase [Energy production and conversion]; Region: COG3426 481743000596 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 481743000597 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 481743000598 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 481743000599 phosphate binding site [ion binding]; other site 481743000600 putative substrate binding pocket [chemical binding]; other site 481743000601 dimer interface [polypeptide binding]; other site 481743000602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 481743000603 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 481743000604 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 481743000605 dimerization domain swap beta strand [polypeptide binding]; other site 481743000606 regulatory protein interface [polypeptide binding]; other site 481743000607 active site 481743000608 regulatory phosphorylation site [posttranslational modification]; other site 481743000609 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743000610 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743000611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743000612 Walker A/P-loop; other site 481743000613 ATP binding site [chemical binding]; other site 481743000614 Q-loop/lid; other site 481743000615 ABC transporter signature motif; other site 481743000616 Walker B; other site 481743000617 D-loop; other site 481743000618 H-loop/switch region; other site 481743000619 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743000620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743000621 active site 481743000622 phosphorylation site [posttranslational modification] 481743000623 intermolecular recognition site; other site 481743000624 dimerization interface [polypeptide binding]; other site 481743000625 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743000626 DNA binding site [nucleotide binding] 481743000627 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 481743000628 dimerization interface [polypeptide binding]; other site 481743000629 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743000630 dimer interface [polypeptide binding]; other site 481743000631 phosphorylation site [posttranslational modification] 481743000632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743000633 ATP binding site [chemical binding]; other site 481743000634 Mg2+ binding site [ion binding]; other site 481743000635 G-X-G motif; other site 481743000636 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 481743000637 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 481743000638 Walker A/P-loop; other site 481743000639 ATP binding site [chemical binding]; other site 481743000640 Q-loop/lid; other site 481743000641 ABC transporter signature motif; other site 481743000642 Walker B; other site 481743000643 D-loop; other site 481743000644 H-loop/switch region; other site 481743000645 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 481743000646 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481743000647 substrate binding pocket [chemical binding]; other site 481743000648 membrane-bound complex binding site; other site 481743000649 hinge residues; other site 481743000650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743000651 dimer interface [polypeptide binding]; other site 481743000652 conserved gate region; other site 481743000653 putative PBP binding loops; other site 481743000654 ABC-ATPase subunit interface; other site 481743000655 Uncharacterized conserved protein [Function unknown]; Region: COG2968 481743000656 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 481743000657 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 481743000658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743000659 Walker A/P-loop; other site 481743000660 ATP binding site [chemical binding]; other site 481743000661 Q-loop/lid; other site 481743000662 ABC transporter signature motif; other site 481743000663 Walker B; other site 481743000664 D-loop; other site 481743000665 H-loop/switch region; other site 481743000666 TOBE domain; Region: TOBE_2; pfam08402 481743000667 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 481743000668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743000669 dimer interface [polypeptide binding]; other site 481743000670 conserved gate region; other site 481743000671 putative PBP binding loops; other site 481743000672 ABC-ATPase subunit interface; other site 481743000673 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 481743000674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743000675 dimer interface [polypeptide binding]; other site 481743000676 conserved gate region; other site 481743000677 putative PBP binding loops; other site 481743000678 ABC-ATPase subunit interface; other site 481743000679 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 481743000680 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 481743000681 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743000682 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 481743000683 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 481743000684 Clp protease; Region: CLP_protease; pfam00574 481743000685 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 481743000686 oligomer interface [polypeptide binding]; other site 481743000687 active site residues [active] 481743000688 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 481743000689 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 481743000690 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 481743000691 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 481743000692 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 481743000693 Phosphoglycerate kinase; Region: PGK; pfam00162 481743000694 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 481743000695 substrate binding site [chemical binding]; other site 481743000696 hinge regions; other site 481743000697 ADP binding site [chemical binding]; other site 481743000698 catalytic site [active] 481743000699 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 481743000700 triosephosphate isomerase; Provisional; Region: PRK14565 481743000701 substrate binding site [chemical binding]; other site 481743000702 dimer interface [polypeptide binding]; other site 481743000703 catalytic triad [active] 481743000704 phosphoglyceromutase; Provisional; Region: PRK05434 481743000705 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 481743000706 enolase; Provisional; Region: eno; PRK00077 481743000707 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 481743000708 dimer interface [polypeptide binding]; other site 481743000709 metal binding site [ion binding]; metal-binding site 481743000710 substrate binding pocket [chemical binding]; other site 481743000711 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 481743000712 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 481743000713 S-layer homology domain; Region: SLH; pfam00395 481743000714 S-layer homology domain; Region: SLH; pfam00395 481743000715 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743000716 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743000717 dimerization interface [polypeptide binding]; other site 481743000718 Histidine kinase; Region: His_kinase; pfam06580 481743000719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743000720 ATP binding site [chemical binding]; other site 481743000721 Mg2+ binding site [ion binding]; other site 481743000722 G-X-G motif; other site 481743000723 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 481743000724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743000725 active site 481743000726 phosphorylation site [posttranslational modification] 481743000727 intermolecular recognition site; other site 481743000728 dimerization interface [polypeptide binding]; other site 481743000729 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743000730 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743000731 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743000732 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743000733 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 481743000734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743000735 dimer interface [polypeptide binding]; other site 481743000736 conserved gate region; other site 481743000737 putative PBP binding loops; other site 481743000738 ABC-ATPase subunit interface; other site 481743000739 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743000740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743000741 dimer interface [polypeptide binding]; other site 481743000742 conserved gate region; other site 481743000743 putative PBP binding loops; other site 481743000744 ABC-ATPase subunit interface; other site 481743000745 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 481743000746 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743000747 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743000748 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 481743000749 dimerization interface [polypeptide binding]; other site 481743000750 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 481743000751 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 481743000752 Tetramer interface [polypeptide binding]; other site 481743000753 active site 481743000754 FMN-binding site [chemical binding]; other site 481743000755 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 481743000756 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 481743000757 putative active site [active] 481743000758 putative FMN binding site [chemical binding]; other site 481743000759 putative substrate binding site [chemical binding]; other site 481743000760 putative catalytic residue [active] 481743000761 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743000762 dimerization interface [polypeptide binding]; other site 481743000763 putative DNA binding site [nucleotide binding]; other site 481743000764 putative Zn2+ binding site [ion binding]; other site 481743000765 hypothetical protein; Provisional; Region: PRK07758 481743000766 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 481743000767 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 481743000768 siderophore binding site; other site 481743000769 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 481743000770 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481743000771 ABC-ATPase subunit interface; other site 481743000772 dimer interface [polypeptide binding]; other site 481743000773 putative PBP binding regions; other site 481743000774 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481743000775 ABC-ATPase subunit interface; other site 481743000776 dimer interface [polypeptide binding]; other site 481743000777 putative PBP binding regions; other site 481743000778 Predicted transcriptional regulator [Transcription]; Region: COG4189 481743000779 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743000780 dimerization interface [polypeptide binding]; other site 481743000781 putative DNA binding site [nucleotide binding]; other site 481743000782 putative Zn2+ binding site [ion binding]; other site 481743000783 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 481743000784 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 481743000785 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 481743000786 S-layer homology domain; Region: SLH; pfam00395 481743000787 S-layer homology domain; Region: SLH; pfam00395 481743000788 S-layer homology domain; Region: SLH; pfam00395 481743000789 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 481743000790 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 481743000791 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 481743000792 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 481743000793 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481743000794 ATP binding site [chemical binding]; other site 481743000795 putative Mg++ binding site [ion binding]; other site 481743000796 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481743000797 nucleotide binding region [chemical binding]; other site 481743000798 ATP-binding site [chemical binding]; other site 481743000799 Phosphotransferase enzyme family; Region: APH; pfam01636 481743000800 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 481743000801 active site 481743000802 ATP binding site [chemical binding]; other site 481743000803 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743000804 substrate binding site [chemical binding]; other site 481743000805 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743000806 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743000807 DNA binding site [nucleotide binding] 481743000808 domain linker motif; other site 481743000809 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743000810 dimerization interface [polypeptide binding]; other site 481743000811 ligand binding site [chemical binding]; other site 481743000812 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743000813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743000814 dimer interface [polypeptide binding]; other site 481743000815 conserved gate region; other site 481743000816 putative PBP binding loops; other site 481743000817 ABC-ATPase subunit interface; other site 481743000818 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743000819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743000820 dimer interface [polypeptide binding]; other site 481743000821 conserved gate region; other site 481743000822 putative PBP binding loops; other site 481743000823 ABC-ATPase subunit interface; other site 481743000824 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743000825 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 481743000826 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 481743000827 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743000828 putative DNA binding site [nucleotide binding]; other site 481743000829 dimerization interface [polypeptide binding]; other site 481743000830 putative Zn2+ binding site [ion binding]; other site 481743000831 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 481743000832 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 481743000833 active site 481743000834 HIGH motif; other site 481743000835 KMSKS motif; other site 481743000836 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 481743000837 tRNA binding surface [nucleotide binding]; other site 481743000838 anticodon binding site; other site 481743000839 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 481743000840 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743000841 dimerization interface [polypeptide binding]; other site 481743000842 putative DNA binding site [nucleotide binding]; other site 481743000843 putative Zn2+ binding site [ion binding]; other site 481743000844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743000845 ATP binding site [chemical binding]; other site 481743000846 Mg2+ binding site [ion binding]; other site 481743000847 G-X-G motif; other site 481743000848 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743000849 Coenzyme A binding pocket [chemical binding]; other site 481743000850 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 481743000851 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 481743000852 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 481743000853 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 481743000854 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 481743000855 Walker A/P-loop; other site 481743000856 ATP binding site [chemical binding]; other site 481743000857 Q-loop/lid; other site 481743000858 ABC transporter signature motif; other site 481743000859 Walker B; other site 481743000860 D-loop; other site 481743000861 H-loop/switch region; other site 481743000862 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 481743000863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743000864 dimer interface [polypeptide binding]; other site 481743000865 conserved gate region; other site 481743000866 putative PBP binding loops; other site 481743000867 ABC-ATPase subunit interface; other site 481743000868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743000869 dimer interface [polypeptide binding]; other site 481743000870 conserved gate region; other site 481743000871 putative PBP binding loops; other site 481743000872 ABC-ATPase subunit interface; other site 481743000873 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 481743000874 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 481743000875 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 481743000876 catalytic residue [active] 481743000877 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 481743000878 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743000879 motif II; other site 481743000880 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 481743000881 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 481743000882 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 481743000883 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 481743000884 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 481743000885 Peptidase family M28; Region: Peptidase_M28; pfam04389 481743000886 metal binding site [ion binding]; metal-binding site 481743000887 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 481743000888 active site 481743000889 NTP binding site [chemical binding]; other site 481743000890 metal binding triad [ion binding]; metal-binding site 481743000891 KNTase C-terminal domain; Region: KNTase_C; pfam07827 481743000892 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743000893 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743000894 short chain dehydrogenase; Provisional; Region: PRK12939 481743000895 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 481743000896 NADP binding site [chemical binding]; other site 481743000897 homodimer interface [polypeptide binding]; other site 481743000898 active site 481743000899 substrate binding site [chemical binding]; other site 481743000900 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 481743000901 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 481743000902 metal binding site [ion binding]; metal-binding site 481743000903 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 481743000904 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 481743000905 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 481743000906 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 481743000907 Ligand binding site [chemical binding]; other site 481743000908 Electron transfer flavoprotein domain; Region: ETF; pfam01012 481743000909 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743000910 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743000911 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 481743000912 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 481743000913 4Fe-4S binding domain; Region: Fer4; cl02805 481743000914 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 481743000915 Cysteine-rich domain; Region: CCG; pfam02754 481743000916 Cysteine-rich domain; Region: CCG; pfam02754 481743000917 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 481743000918 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 481743000919 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 481743000920 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 481743000921 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 481743000922 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 481743000923 substrate binding site [chemical binding]; other site 481743000924 oxyanion hole (OAH) forming residues; other site 481743000925 trimer interface [polypeptide binding]; other site 481743000926 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 481743000927 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 481743000928 dimer interface [polypeptide binding]; other site 481743000929 active site 481743000930 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 481743000931 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 481743000932 active site 481743000933 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 481743000934 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 481743000935 acyl-activating enzyme (AAE) consensus motif; other site 481743000936 putative AMP binding site [chemical binding]; other site 481743000937 putative active site [active] 481743000938 putative CoA binding site [chemical binding]; other site 481743000939 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 481743000940 CoenzymeA binding site [chemical binding]; other site 481743000941 subunit interaction site [polypeptide binding]; other site 481743000942 PHB binding site; other site 481743000943 Preprotein translocase SecG subunit; Region: SecG; cl09123 481743000944 ribonuclease R; Region: RNase_R; TIGR02063 481743000945 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 481743000946 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 481743000947 RNB domain; Region: RNB; pfam00773 481743000948 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 481743000949 RNA binding site [nucleotide binding]; other site 481743000950 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 481743000951 SmpB-tmRNA interface; other site 481743000952 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 481743000953 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 481743000954 putative active site [active] 481743000955 putative NTP binding site [chemical binding]; other site 481743000956 putative nucleic acid binding site [nucleotide binding]; other site 481743000957 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 481743000958 Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain [Function unknown]; Region: COG4916 481743000959 TIR domain; Region: TIR_2; pfam13676 481743000960 Restriction endonuclease; Region: Mrr_cat; pfam04471 481743000961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743000962 Walker A motif; other site 481743000963 ATP binding site [chemical binding]; other site 481743000964 Walker B motif; other site 481743000965 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481743000966 non-specific DNA binding site [nucleotide binding]; other site 481743000967 salt bridge; other site 481743000968 sequence-specific DNA binding site [nucleotide binding]; other site 481743000969 RRXRR protein; Region: RRXRR; pfam14239 481743000970 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 481743000971 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 481743000972 active site 481743000973 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743000974 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481743000975 Walker A/P-loop; other site 481743000976 ATP binding site [chemical binding]; other site 481743000977 Q-loop/lid; other site 481743000978 ABC transporter signature motif; other site 481743000979 Walker B; other site 481743000980 D-loop; other site 481743000981 H-loop/switch region; other site 481743000982 ABC-2 type transporter; Region: ABC2_membrane; cl17235 481743000983 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 481743000984 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 481743000985 Histidine kinase; Region: HisKA_3; pfam07730 481743000986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743000987 ATP binding site [chemical binding]; other site 481743000988 Mg2+ binding site [ion binding]; other site 481743000989 G-X-G motif; other site 481743000990 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743000991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743000992 active site 481743000993 phosphorylation site [posttranslational modification] 481743000994 intermolecular recognition site; other site 481743000995 dimerization interface [polypeptide binding]; other site 481743000996 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743000997 DNA binding residues [nucleotide binding] 481743000998 dimerization interface [polypeptide binding]; other site 481743000999 Putative sensor; Region: Sensor; pfam13796 481743001000 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 481743001001 Pectate lyase; Region: Pec_lyase_C; cl01593 481743001002 Fic/DOC family; Region: Fic; cl00960 481743001003 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 481743001004 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743001005 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743001006 dimerization interface [polypeptide binding]; other site 481743001007 Histidine kinase; Region: His_kinase; pfam06580 481743001008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743001009 ATP binding site [chemical binding]; other site 481743001010 Mg2+ binding site [ion binding]; other site 481743001011 G-X-G motif; other site 481743001012 Response regulator receiver domain; Region: Response_reg; pfam00072 481743001013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743001014 active site 481743001015 phosphorylation site [posttranslational modification] 481743001016 intermolecular recognition site; other site 481743001017 dimerization interface [polypeptide binding]; other site 481743001018 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743001019 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743001020 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743001021 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743001022 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743001023 Class I aldolases; Region: Aldolase_Class_I; cl17187 481743001024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001025 dimer interface [polypeptide binding]; other site 481743001026 conserved gate region; other site 481743001027 putative PBP binding loops; other site 481743001028 ABC-ATPase subunit interface; other site 481743001029 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743001030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001031 dimer interface [polypeptide binding]; other site 481743001032 conserved gate region; other site 481743001033 putative PBP binding loops; other site 481743001034 ABC-ATPase subunit interface; other site 481743001035 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 481743001036 RRXRR protein; Region: RRXRR; pfam14239 481743001037 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 481743001038 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 481743001039 active site 481743001040 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 481743001041 Mechanosensitive ion channel; Region: MS_channel; pfam00924 481743001042 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 481743001043 putative substrate binding site [chemical binding]; other site 481743001044 active site 481743001045 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 481743001046 ligand binding site [chemical binding]; other site 481743001047 active site 481743001048 UGI interface [polypeptide binding]; other site 481743001049 catalytic site [active] 481743001050 Response regulator receiver domain; Region: Response_reg; pfam00072 481743001051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743001052 active site 481743001053 phosphorylation site [posttranslational modification] 481743001054 intermolecular recognition site; other site 481743001055 dimerization interface [polypeptide binding]; other site 481743001056 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 481743001057 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 481743001058 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743001059 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 481743001060 Response regulator receiver domain; Region: Response_reg; pfam00072 481743001061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743001062 active site 481743001063 phosphorylation site [posttranslational modification] 481743001064 intermolecular recognition site; other site 481743001065 dimerization interface [polypeptide binding]; other site 481743001066 Histidine kinase; Region: His_kinase; pfam06580 481743001067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743001068 ATP binding site [chemical binding]; other site 481743001069 Mg2+ binding site [ion binding]; other site 481743001070 G-X-G motif; other site 481743001071 S-layer homology domain; Region: SLH; pfam00395 481743001072 S-layer homology domain; Region: SLH; pfam00395 481743001073 Ycf46; Provisional; Region: ycf46; CHL00195 481743001074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743001075 Walker A motif; other site 481743001076 ATP binding site [chemical binding]; other site 481743001077 Walker B motif; other site 481743001078 arginine finger; other site 481743001079 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 481743001080 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 481743001081 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 481743001082 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 481743001083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 481743001084 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 481743001085 Propionate catabolism activator; Region: PrpR_N; pfam06506 481743001086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 481743001087 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 481743001088 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 481743001089 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 481743001090 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 481743001091 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 481743001092 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 481743001093 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 481743001094 DNA-binding site [nucleotide binding]; DNA binding site 481743001095 RNA-binding motif; other site 481743001096 Cold-inducible protein YdjO; Region: YdjO; pfam14169 481743001097 Helix-turn-helix domain; Region: HTH_17; cl17695 481743001098 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 481743001099 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 481743001100 putative dimer interface [polypeptide binding]; other site 481743001101 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 481743001102 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 481743001103 Double zinc ribbon; Region: DZR; pfam12773 481743001104 Repair protein; Region: Repair_PSII; pfam04536 481743001105 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 481743001106 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 481743001107 Double zinc ribbon; Region: DZR; pfam12773 481743001108 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743001109 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743001110 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743001111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001112 dimer interface [polypeptide binding]; other site 481743001113 conserved gate region; other site 481743001114 putative PBP binding loops; other site 481743001115 ABC-ATPase subunit interface; other site 481743001116 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743001117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001118 dimer interface [polypeptide binding]; other site 481743001119 conserved gate region; other site 481743001120 putative PBP binding loops; other site 481743001121 ABC-ATPase subunit interface; other site 481743001122 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743001123 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743001124 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 481743001125 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 481743001126 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 481743001127 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 481743001128 ligand binding site [chemical binding]; other site 481743001129 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 481743001130 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743001131 Walker A/P-loop; other site 481743001132 ATP binding site [chemical binding]; other site 481743001133 Q-loop/lid; other site 481743001134 ABC transporter signature motif; other site 481743001135 Walker B; other site 481743001136 D-loop; other site 481743001137 H-loop/switch region; other site 481743001138 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 481743001139 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481743001140 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 481743001141 TM-ABC transporter signature motif; other site 481743001142 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481743001143 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 481743001144 TM-ABC transporter signature motif; other site 481743001145 Lamin Tail Domain; Region: LTD; pfam00932 481743001146 Fn3 associated; Region: Fn3_assoc; pfam13287 481743001147 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 481743001148 generic binding surface I; other site 481743001149 generic binding surface II; other site 481743001150 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 481743001151 putative active site [active] 481743001152 putative catalytic site [active] 481743001153 putative Mg binding site IVb [ion binding]; other site 481743001154 putative phosphate binding site [ion binding]; other site 481743001155 putative DNA binding site [nucleotide binding]; other site 481743001156 putative Mg binding site IVa [ion binding]; other site 481743001157 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 481743001158 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 481743001159 active site 481743001160 metal binding site [ion binding]; metal-binding site 481743001161 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 481743001162 S-layer homology domain; Region: SLH; pfam00395 481743001163 S-layer homology domain; Region: SLH; pfam00395 481743001164 S-layer homology domain; Region: SLH; pfam00395 481743001165 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 481743001166 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743001167 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743001168 DNA binding residues [nucleotide binding] 481743001169 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743001170 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743001171 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743001172 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743001173 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 481743001174 Sulfatase; Region: Sulfatase; pfam00884 481743001175 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 481743001176 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 481743001177 putative active site [active] 481743001178 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743001179 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743001180 DNA binding site [nucleotide binding] 481743001181 domain linker motif; other site 481743001182 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743001183 dimerization interface [polypeptide binding]; other site 481743001184 ligand binding site [chemical binding]; other site 481743001185 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743001186 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743001187 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 481743001188 structural tetrad; other site 481743001189 PQQ-like domain; Region: PQQ_2; pfam13360 481743001190 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743001191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001192 dimer interface [polypeptide binding]; other site 481743001193 conserved gate region; other site 481743001194 putative PBP binding loops; other site 481743001195 ABC-ATPase subunit interface; other site 481743001196 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743001197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001198 dimer interface [polypeptide binding]; other site 481743001199 conserved gate region; other site 481743001200 putative PBP binding loops; other site 481743001201 ABC-ATPase subunit interface; other site 481743001202 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 481743001203 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 481743001204 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 481743001205 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 481743001206 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 481743001207 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 481743001208 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 481743001209 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 481743001210 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 481743001211 carbohydrate binding site [chemical binding]; other site 481743001212 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 481743001213 carbohydrate binding site [chemical binding]; other site 481743001214 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 481743001215 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 481743001216 Ca binding site [ion binding]; other site 481743001217 active site 481743001218 catalytic site [active] 481743001219 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 481743001220 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 481743001221 carbohydrate binding site [chemical binding]; other site 481743001222 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 481743001223 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 481743001224 active site 481743001225 catalytic site [active] 481743001226 S-layer homology domain; Region: SLH; pfam00395 481743001227 S-layer homology domain; Region: SLH; pfam00395 481743001228 S-layer homology domain; Region: SLH; pfam00395 481743001229 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 481743001230 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 481743001231 active site 481743001232 PHP-associated; Region: PHP_C; pfam13263 481743001233 Cobalt transport protein; Region: CbiQ; cl00463 481743001234 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 481743001235 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 481743001236 Walker A/P-loop; other site 481743001237 ATP binding site [chemical binding]; other site 481743001238 Q-loop/lid; other site 481743001239 ABC transporter signature motif; other site 481743001240 Walker B; other site 481743001241 D-loop; other site 481743001242 H-loop/switch region; other site 481743001243 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 481743001244 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 481743001245 Walker A/P-loop; other site 481743001246 ATP binding site [chemical binding]; other site 481743001247 Q-loop/lid; other site 481743001248 ABC transporter signature motif; other site 481743001249 Walker B; other site 481743001250 D-loop; other site 481743001251 H-loop/switch region; other site 481743001252 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 481743001253 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 481743001254 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 481743001255 putative active site [active] 481743001256 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 481743001257 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 481743001258 metal ion-dependent adhesion site (MIDAS); other site 481743001259 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 481743001260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743001261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743001262 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743001263 substrate binding site [chemical binding]; other site 481743001264 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 481743001265 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 481743001266 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 481743001267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001268 dimer interface [polypeptide binding]; other site 481743001269 conserved gate region; other site 481743001270 putative PBP binding loops; other site 481743001271 ABC-ATPase subunit interface; other site 481743001272 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 481743001273 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 481743001274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001275 putative PBP binding loops; other site 481743001276 ABC-ATPase subunit interface; other site 481743001277 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 481743001278 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743001279 Walker A/P-loop; other site 481743001280 ATP binding site [chemical binding]; other site 481743001281 Q-loop/lid; other site 481743001282 ABC transporter signature motif; other site 481743001283 Walker B; other site 481743001284 D-loop; other site 481743001285 H-loop/switch region; other site 481743001286 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 481743001287 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 481743001288 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743001289 Walker A/P-loop; other site 481743001290 ATP binding site [chemical binding]; other site 481743001291 Q-loop/lid; other site 481743001292 ABC transporter signature motif; other site 481743001293 Walker B; other site 481743001294 D-loop; other site 481743001295 H-loop/switch region; other site 481743001296 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 481743001297 OsmC-like protein; Region: OsmC; pfam02566 481743001298 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 481743001299 hypothetical protein; Provisional; Region: PRK09739 481743001300 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 481743001301 Predicted transcriptional regulators [Transcription]; Region: COG1733 481743001302 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 481743001303 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 481743001304 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 481743001305 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 481743001306 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 481743001307 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481743001308 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481743001309 metal binding site [ion binding]; metal-binding site 481743001310 active site 481743001311 I-site; other site 481743001312 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 481743001313 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 481743001314 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743001315 FeS/SAM binding site; other site 481743001316 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 481743001317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743001318 DNA-binding site [nucleotide binding]; DNA binding site 481743001319 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743001320 dimerization interface [polypeptide binding]; other site 481743001321 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 481743001322 ligand binding site [chemical binding]; other site 481743001323 Uncharacterized conserved protein [Function unknown]; Region: COG3538 481743001324 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 481743001325 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743001326 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743001327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001328 dimer interface [polypeptide binding]; other site 481743001329 putative PBP binding loops; other site 481743001330 ABC-ATPase subunit interface; other site 481743001331 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743001332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001333 dimer interface [polypeptide binding]; other site 481743001334 conserved gate region; other site 481743001335 putative PBP binding loops; other site 481743001336 ABC-ATPase subunit interface; other site 481743001337 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 481743001338 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 481743001339 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 481743001340 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 481743001341 active site 481743001342 ATP binding site [chemical binding]; other site 481743001343 substrate binding site [chemical binding]; other site 481743001344 activation loop (A-loop); other site 481743001345 AAA ATPase domain; Region: AAA_16; pfam13191 481743001346 Predicted ATPase [General function prediction only]; Region: COG3899 481743001347 Tetratricopeptide repeat; Region: TPR_12; pfam13424 481743001348 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 481743001349 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 481743001350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 481743001351 Histidine kinase; Region: HisKA_3; pfam07730 481743001352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743001353 ATP binding site [chemical binding]; other site 481743001354 Mg2+ binding site [ion binding]; other site 481743001355 G-X-G motif; other site 481743001356 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743001357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743001358 active site 481743001359 phosphorylation site [posttranslational modification] 481743001360 intermolecular recognition site; other site 481743001361 dimerization interface [polypeptide binding]; other site 481743001362 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743001363 dimerization interface [polypeptide binding]; other site 481743001364 DNA binding residues [nucleotide binding] 481743001365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743001366 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 481743001367 Q-loop/lid; other site 481743001368 ABC transporter signature motif; other site 481743001369 Walker B; other site 481743001370 D-loop; other site 481743001371 H-loop/switch region; other site 481743001372 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 481743001373 LytTr DNA-binding domain; Region: LytTR; pfam04397 481743001374 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743001375 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481743001376 Walker A/P-loop; other site 481743001377 ATP binding site [chemical binding]; other site 481743001378 Q-loop/lid; other site 481743001379 ABC transporter signature motif; other site 481743001380 Walker B; other site 481743001381 D-loop; other site 481743001382 H-loop/switch region; other site 481743001383 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 481743001384 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 481743001385 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 481743001386 Na2 binding site [ion binding]; other site 481743001387 putative substrate binding site 1 [chemical binding]; other site 481743001388 Na binding site 1 [ion binding]; other site 481743001389 putative substrate binding site 2 [chemical binding]; other site 481743001390 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 481743001391 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 481743001392 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 481743001393 DXD motif; other site 481743001394 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481743001395 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481743001396 metal binding site [ion binding]; metal-binding site 481743001397 active site 481743001398 I-site; other site 481743001399 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 481743001400 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743001401 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 481743001402 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 481743001403 Uncharacterized conserved protein [Function unknown]; Region: COG2128 481743001404 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 481743001405 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 481743001406 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743001407 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743001408 DNA binding residues [nucleotide binding] 481743001409 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 481743001410 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 481743001411 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 481743001412 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 481743001413 ligand binding site [chemical binding]; other site 481743001414 metal binding site [ion binding]; metal-binding site 481743001415 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 481743001416 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 481743001417 ligand binding site [chemical binding]; other site 481743001418 flexible hinge region; other site 481743001419 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 481743001420 non-specific DNA interactions [nucleotide binding]; other site 481743001421 DNA binding site [nucleotide binding] 481743001422 sequence specific DNA binding site [nucleotide binding]; other site 481743001423 putative cAMP binding site [chemical binding]; other site 481743001424 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 481743001425 ApbE family; Region: ApbE; pfam02424 481743001426 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 481743001427 trimer interface [polypeptide binding]; other site 481743001428 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 481743001429 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 481743001430 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 481743001431 Walker A/P-loop; other site 481743001432 ATP binding site [chemical binding]; other site 481743001433 Q-loop/lid; other site 481743001434 ABC transporter signature motif; other site 481743001435 Walker B; other site 481743001436 D-loop; other site 481743001437 H-loop/switch region; other site 481743001438 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 481743001439 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 481743001440 Walker A/P-loop; other site 481743001441 ATP binding site [chemical binding]; other site 481743001442 Q-loop/lid; other site 481743001443 ABC transporter signature motif; other site 481743001444 Walker B; other site 481743001445 D-loop; other site 481743001446 H-loop/switch region; other site 481743001447 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 481743001448 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 481743001449 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 481743001450 catalytic residues [active] 481743001451 Sporulation and spore germination; Region: Germane; pfam10646 481743001452 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 481743001453 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 481743001454 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 481743001455 substrate binding pocket [chemical binding]; other site 481743001456 chain length determination region; other site 481743001457 substrate-Mg2+ binding site; other site 481743001458 catalytic residues [active] 481743001459 aspartate-rich region 1; other site 481743001460 active site lid residues [active] 481743001461 aspartate-rich region 2; other site 481743001462 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 481743001463 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481743001464 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 481743001465 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 481743001466 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 481743001467 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 481743001468 heterodimer interface [polypeptide binding]; other site 481743001469 active site 481743001470 FMN binding site [chemical binding]; other site 481743001471 homodimer interface [polypeptide binding]; other site 481743001472 substrate binding site [chemical binding]; other site 481743001473 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 481743001474 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 481743001475 FAD binding pocket [chemical binding]; other site 481743001476 FAD binding motif [chemical binding]; other site 481743001477 phosphate binding motif [ion binding]; other site 481743001478 beta-alpha-beta structure motif; other site 481743001479 NAD binding pocket [chemical binding]; other site 481743001480 Iron coordination center [ion binding]; other site 481743001481 Predicted transcriptional regulators [Transcription]; Region: COG1695 481743001482 Transcriptional regulator PadR-like family; Region: PadR; cl17335 481743001483 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 481743001484 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 481743001485 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 481743001486 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743001487 Walker A/P-loop; other site 481743001488 ATP binding site [chemical binding]; other site 481743001489 Q-loop/lid; other site 481743001490 ABC transporter signature motif; other site 481743001491 Walker B; other site 481743001492 D-loop; other site 481743001493 H-loop/switch region; other site 481743001494 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 481743001495 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 481743001496 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743001497 Walker A/P-loop; other site 481743001498 ATP binding site [chemical binding]; other site 481743001499 Q-loop/lid; other site 481743001500 ABC transporter signature motif; other site 481743001501 Walker B; other site 481743001502 D-loop; other site 481743001503 H-loop/switch region; other site 481743001504 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 481743001505 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 481743001506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001507 dimer interface [polypeptide binding]; other site 481743001508 conserved gate region; other site 481743001509 putative PBP binding loops; other site 481743001510 ABC-ATPase subunit interface; other site 481743001511 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 481743001512 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 481743001513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001514 dimer interface [polypeptide binding]; other site 481743001515 conserved gate region; other site 481743001516 putative PBP binding loops; other site 481743001517 ABC-ATPase subunit interface; other site 481743001518 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 481743001519 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 481743001520 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743001521 dimerization interface [polypeptide binding]; other site 481743001522 putative DNA binding site [nucleotide binding]; other site 481743001523 putative Zn2+ binding site [ion binding]; other site 481743001524 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 481743001525 hydrophobic ligand binding site; other site 481743001526 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 481743001527 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743001528 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743001529 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 481743001530 putative dimerization interface [polypeptide binding]; other site 481743001531 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 481743001532 EamA-like transporter family; Region: EamA; pfam00892 481743001533 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743001534 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743001535 DNA binding site [nucleotide binding] 481743001536 domain linker motif; other site 481743001537 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743001538 dimerization interface [polypeptide binding]; other site 481743001539 ligand binding site [chemical binding]; other site 481743001540 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743001541 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 481743001542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001543 dimer interface [polypeptide binding]; other site 481743001544 conserved gate region; other site 481743001545 putative PBP binding loops; other site 481743001546 ABC-ATPase subunit interface; other site 481743001547 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743001548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001549 dimer interface [polypeptide binding]; other site 481743001550 conserved gate region; other site 481743001551 putative PBP binding loops; other site 481743001552 ABC-ATPase subunit interface; other site 481743001553 Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802 481743001554 putative active site [active] 481743001555 YdjC motif; other site 481743001556 Mg binding site [ion binding]; other site 481743001557 homodimer interface [polypeptide binding]; other site 481743001558 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 481743001559 Beta-lactamase; Region: Beta-lactamase; pfam00144 481743001560 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 481743001561 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 481743001562 Glutamate binding site [chemical binding]; other site 481743001563 homodimer interface [polypeptide binding]; other site 481743001564 NAD binding site [chemical binding]; other site 481743001565 catalytic residues [active] 481743001566 Proline dehydrogenase; Region: Pro_dh; cl03282 481743001567 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 481743001568 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 481743001569 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 481743001570 Soluble P-type ATPase [General function prediction only]; Region: COG4087 481743001571 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 481743001572 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 481743001573 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 481743001574 Ligand Binding Site [chemical binding]; other site 481743001575 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 481743001576 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 481743001577 Ligand Binding Site [chemical binding]; other site 481743001578 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 481743001579 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 481743001580 ATP-binding site [chemical binding]; other site 481743001581 Sugar specificity; other site 481743001582 Pyrimidine base specificity; other site 481743001583 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 481743001584 putative ligand binding site [chemical binding]; other site 481743001585 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481743001586 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481743001587 active site 481743001588 catalytic tetrad [active] 481743001589 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 481743001590 Competence protein J (ComJ); Region: ComJ; pfam11033 481743001591 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 481743001592 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 481743001593 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743001594 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 481743001595 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 481743001596 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 481743001597 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743001598 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743001599 DNA binding residues [nucleotide binding] 481743001600 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 481743001601 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 481743001602 dimer interface [polypeptide binding]; other site 481743001603 active site 481743001604 Helix-turn-helix domain; Region: HTH_31; pfam13560 481743001605 SNF2 Helicase protein; Region: DUF3670; pfam12419 481743001606 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 481743001607 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481743001608 ATP binding site [chemical binding]; other site 481743001609 putative Mg++ binding site [ion binding]; other site 481743001610 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481743001611 nucleotide binding region [chemical binding]; other site 481743001612 ATP-binding site [chemical binding]; other site 481743001613 SWIM zinc finger; Region: SWIM; pfam04434 481743001614 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 481743001615 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743001616 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743001617 Histidine kinase; Region: His_kinase; pfam06580 481743001618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743001619 ATP binding site [chemical binding]; other site 481743001620 Mg2+ binding site [ion binding]; other site 481743001621 G-X-G motif; other site 481743001622 Response regulator receiver domain; Region: Response_reg; pfam00072 481743001623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743001624 active site 481743001625 phosphorylation site [posttranslational modification] 481743001626 intermolecular recognition site; other site 481743001627 dimerization interface [polypeptide binding]; other site 481743001628 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743001629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743001630 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743001631 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743001632 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743001633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001634 dimer interface [polypeptide binding]; other site 481743001635 conserved gate region; other site 481743001636 putative PBP binding loops; other site 481743001637 ABC-ATPase subunit interface; other site 481743001638 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743001639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001640 dimer interface [polypeptide binding]; other site 481743001641 conserved gate region; other site 481743001642 putative PBP binding loops; other site 481743001643 ABC-ATPase subunit interface; other site 481743001644 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 481743001645 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 481743001646 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 481743001647 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 481743001648 DNA binding site [nucleotide binding] 481743001649 active site 481743001650 H+ Antiporter protein; Region: 2A0121; TIGR00900 481743001651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743001652 putative substrate translocation pore; other site 481743001653 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743001654 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743001655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743001656 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743001657 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 481743001658 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743001659 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743001660 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743001661 Glycosyl hydrolase family 43; Region: GH43_2; cd08981 481743001662 active site 481743001663 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 481743001664 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743001665 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743001666 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743001667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001668 dimer interface [polypeptide binding]; other site 481743001669 conserved gate region; other site 481743001670 putative PBP binding loops; other site 481743001671 ABC-ATPase subunit interface; other site 481743001672 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743001673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001674 dimer interface [polypeptide binding]; other site 481743001675 conserved gate region; other site 481743001676 putative PBP binding loops; other site 481743001677 ABC-ATPase subunit interface; other site 481743001678 Response regulator receiver domain; Region: Response_reg; pfam00072 481743001679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743001680 active site 481743001681 phosphorylation site [posttranslational modification] 481743001682 intermolecular recognition site; other site 481743001683 dimerization interface [polypeptide binding]; other site 481743001684 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743001685 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743001686 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743001687 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 481743001688 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743001689 Histidine kinase; Region: His_kinase; pfam06580 481743001690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743001691 ATP binding site [chemical binding]; other site 481743001692 Mg2+ binding site [ion binding]; other site 481743001693 G-X-G motif; other site 481743001694 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743001695 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743001696 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743001697 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743001698 Helix-turn-helix domain; Region: HTH_18; pfam12833 481743001699 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743001700 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 481743001701 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 481743001702 GIY-YIG motif/motif A; other site 481743001703 active site 481743001704 catalytic site [active] 481743001705 putative DNA binding site [nucleotide binding]; other site 481743001706 metal binding site [ion binding]; metal-binding site 481743001707 UvrB/uvrC motif; Region: UVR; pfam02151 481743001708 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743001709 Phosphotransferase enzyme family; Region: APH; pfam01636 481743001710 active site 481743001711 ATP binding site [chemical binding]; other site 481743001712 beta-phosphoglucomutase; Region: bPGM; TIGR01990 481743001713 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743001714 motif II; other site 481743001715 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 481743001716 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 481743001717 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 481743001718 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 481743001719 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743001720 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743001721 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743001722 dimerization interface [polypeptide binding]; other site 481743001723 Histidine kinase; Region: His_kinase; pfam06580 481743001724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743001725 ATP binding site [chemical binding]; other site 481743001726 Mg2+ binding site [ion binding]; other site 481743001727 G-X-G motif; other site 481743001728 Response regulator receiver domain; Region: Response_reg; pfam00072 481743001729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743001730 active site 481743001731 phosphorylation site [posttranslational modification] 481743001732 intermolecular recognition site; other site 481743001733 dimerization interface [polypeptide binding]; other site 481743001734 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743001735 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743001736 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743001737 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743001738 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743001739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 481743001740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001741 dimer interface [polypeptide binding]; other site 481743001742 conserved gate region; other site 481743001743 putative PBP binding loops; other site 481743001744 ABC-ATPase subunit interface; other site 481743001745 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743001746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001747 dimer interface [polypeptide binding]; other site 481743001748 conserved gate region; other site 481743001749 putative PBP binding loops; other site 481743001750 ABC-ATPase subunit interface; other site 481743001751 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 481743001752 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 481743001753 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 481743001754 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 481743001755 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 481743001756 DinB superfamily; Region: DinB_2; pfam12867 481743001757 DinB family; Region: DinB; cl17821 481743001758 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 481743001759 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743001760 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 481743001761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001762 dimer interface [polypeptide binding]; other site 481743001763 conserved gate region; other site 481743001764 putative PBP binding loops; other site 481743001765 ABC-ATPase subunit interface; other site 481743001766 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743001767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001768 dimer interface [polypeptide binding]; other site 481743001769 conserved gate region; other site 481743001770 putative PBP binding loops; other site 481743001771 ABC-ATPase subunit interface; other site 481743001772 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 481743001773 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 481743001774 active site 481743001775 catalytic site [active] 481743001776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743001777 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743001778 putative substrate translocation pore; other site 481743001779 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743001780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743001781 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743001782 Predicted membrane protein [Function unknown]; Region: COG2323 481743001783 MFS/sugar transport protein; Region: MFS_2; pfam13347 481743001784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743001785 putative substrate translocation pore; other site 481743001786 Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802 481743001787 putative active site [active] 481743001788 YdjC motif; other site 481743001789 Mg binding site [ion binding]; other site 481743001790 homodimer interface [polypeptide binding]; other site 481743001791 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743001792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743001793 active site 481743001794 phosphorylation site [posttranslational modification] 481743001795 intermolecular recognition site; other site 481743001796 dimerization interface [polypeptide binding]; other site 481743001797 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743001798 DNA binding site [nucleotide binding] 481743001799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743001800 HAMP domain; Region: HAMP; pfam00672 481743001801 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743001802 dimer interface [polypeptide binding]; other site 481743001803 phosphorylation site [posttranslational modification] 481743001804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743001805 ATP binding site [chemical binding]; other site 481743001806 Mg2+ binding site [ion binding]; other site 481743001807 G-X-G motif; other site 481743001808 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 481743001809 Aspartase; Region: Aspartase; cd01357 481743001810 active sites [active] 481743001811 tetramer interface [polypeptide binding]; other site 481743001812 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481743001813 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 481743001814 putative active site [active] 481743001815 heme pocket [chemical binding]; other site 481743001816 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743001817 dimer interface [polypeptide binding]; other site 481743001818 phosphorylation site [posttranslational modification] 481743001819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743001820 ATP binding site [chemical binding]; other site 481743001821 Mg2+ binding site [ion binding]; other site 481743001822 G-X-G motif; other site 481743001823 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 481743001824 homodimer interaction site [polypeptide binding]; other site 481743001825 cofactor binding site; other site 481743001826 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 481743001827 putative hydrophobic ligand binding site [chemical binding]; other site 481743001828 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 481743001829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743001830 NAD(P) binding site [chemical binding]; other site 481743001831 active site 481743001832 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 481743001833 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 481743001834 inhibitor site; inhibition site 481743001835 active site 481743001836 dimer interface [polypeptide binding]; other site 481743001837 catalytic residue [active] 481743001838 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 481743001839 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 481743001840 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 481743001841 putative L-serine binding site [chemical binding]; other site 481743001842 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 481743001843 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 481743001844 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743001845 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743001846 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743001847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001848 dimer interface [polypeptide binding]; other site 481743001849 conserved gate region; other site 481743001850 ABC-ATPase subunit interface; other site 481743001851 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743001852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001853 dimer interface [polypeptide binding]; other site 481743001854 conserved gate region; other site 481743001855 putative PBP binding loops; other site 481743001856 ABC-ATPase subunit interface; other site 481743001857 Helix-turn-helix domain; Region: HTH_18; pfam12833 481743001858 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 481743001859 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 481743001860 putative NAD(P) binding site [chemical binding]; other site 481743001861 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 481743001862 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 481743001863 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 481743001864 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 481743001865 substrate binding site [chemical binding]; other site 481743001866 active site 481743001867 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 481743001868 Predicted membrane protein [Function unknown]; Region: COG2259 481743001869 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 481743001870 dimer interface [polypeptide binding]; other site 481743001871 FMN binding site [chemical binding]; other site 481743001872 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 481743001873 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 481743001874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001875 dimer interface [polypeptide binding]; other site 481743001876 conserved gate region; other site 481743001877 putative PBP binding loops; other site 481743001878 ABC-ATPase subunit interface; other site 481743001879 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 481743001880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001881 dimer interface [polypeptide binding]; other site 481743001882 conserved gate region; other site 481743001883 putative PBP binding loops; other site 481743001884 ABC-ATPase subunit interface; other site 481743001885 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 481743001886 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481743001887 substrate binding pocket [chemical binding]; other site 481743001888 membrane-bound complex binding site; other site 481743001889 hinge residues; other site 481743001890 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 481743001891 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 481743001892 Walker A/P-loop; other site 481743001893 ATP binding site [chemical binding]; other site 481743001894 Q-loop/lid; other site 481743001895 ABC transporter signature motif; other site 481743001896 Walker B; other site 481743001897 D-loop; other site 481743001898 H-loop/switch region; other site 481743001899 Acyltransferase family; Region: Acyl_transf_3; pfam01757 481743001900 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 481743001901 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 481743001902 metal binding site [ion binding]; metal-binding site 481743001903 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 481743001904 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 481743001905 DNA-binding site [nucleotide binding]; DNA binding site 481743001906 RNA-binding motif; other site 481743001907 Cold-inducible protein YdjO; Region: YdjO; pfam14169 481743001908 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743001909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001910 dimer interface [polypeptide binding]; other site 481743001911 conserved gate region; other site 481743001912 putative PBP binding loops; other site 481743001913 ABC-ATPase subunit interface; other site 481743001914 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743001915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001916 dimer interface [polypeptide binding]; other site 481743001917 conserved gate region; other site 481743001918 putative PBP binding loops; other site 481743001919 ABC-ATPase subunit interface; other site 481743001920 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743001921 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743001922 dimerization interface [polypeptide binding]; other site 481743001923 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743001924 Histidine kinase; Region: His_kinase; pfam06580 481743001925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743001926 ATP binding site [chemical binding]; other site 481743001927 Mg2+ binding site [ion binding]; other site 481743001928 G-X-G motif; other site 481743001929 Response regulator receiver domain; Region: Response_reg; pfam00072 481743001930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743001931 active site 481743001932 phosphorylation site [posttranslational modification] 481743001933 intermolecular recognition site; other site 481743001934 dimerization interface [polypeptide binding]; other site 481743001935 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743001936 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743001937 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743001938 dimerization interface [polypeptide binding]; other site 481743001939 putative DNA binding site [nucleotide binding]; other site 481743001940 putative Zn2+ binding site [ion binding]; other site 481743001941 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 481743001942 putative hydrophobic ligand binding site [chemical binding]; other site 481743001943 Predicted flavoprotein [General function prediction only]; Region: COG0431 481743001944 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 481743001945 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 481743001946 active site 481743001947 catalytic triad [active] 481743001948 oxyanion hole [active] 481743001949 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 481743001950 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 481743001951 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743001952 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743001953 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743001954 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743001955 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 481743001956 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 481743001957 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 481743001958 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743001959 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743001960 DNA binding residues [nucleotide binding] 481743001961 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 481743001962 active site 481743001963 homotetramer interface [polypeptide binding]; other site 481743001964 homodimer interface [polypeptide binding]; other site 481743001965 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743001966 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743001967 DNA binding site [nucleotide binding] 481743001968 domain linker motif; other site 481743001969 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743001970 dimerization interface [polypeptide binding]; other site 481743001971 ligand binding site [chemical binding]; other site 481743001972 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743001973 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743001974 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743001975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001976 dimer interface [polypeptide binding]; other site 481743001977 conserved gate region; other site 481743001978 putative PBP binding loops; other site 481743001979 ABC-ATPase subunit interface; other site 481743001980 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743001981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743001982 dimer interface [polypeptide binding]; other site 481743001983 conserved gate region; other site 481743001984 putative PBP binding loops; other site 481743001985 ABC-ATPase subunit interface; other site 481743001986 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743001987 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743001988 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743001989 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 481743001990 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743001991 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743001992 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743001993 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 481743001994 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 481743001995 active site 481743001996 trimer interface [polypeptide binding]; other site 481743001997 allosteric site; other site 481743001998 active site lid [active] 481743001999 hexamer (dimer of trimers) interface [polypeptide binding]; other site 481743002000 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 481743002001 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 481743002002 active site 481743002003 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 481743002004 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 481743002005 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 481743002006 putative FMN binding site [chemical binding]; other site 481743002007 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481743002008 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481743002009 active site 481743002010 catalytic tetrad [active] 481743002011 Predicted transcriptional regulators [Transcription]; Region: COG1695 481743002012 Transcriptional regulator PadR-like family; Region: PadR; cl17335 481743002013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743002014 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743002015 putative substrate translocation pore; other site 481743002016 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743002017 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 481743002018 active site 481743002019 metal binding site [ion binding]; metal-binding site 481743002020 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 481743002021 active site 481743002022 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 481743002023 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 481743002024 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 481743002025 Ca binding site [ion binding]; other site 481743002026 active site 481743002027 catalytic site [active] 481743002028 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 481743002029 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743002030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002031 dimer interface [polypeptide binding]; other site 481743002032 conserved gate region; other site 481743002033 putative PBP binding loops; other site 481743002034 ABC-ATPase subunit interface; other site 481743002035 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 481743002036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002037 putative PBP binding loops; other site 481743002038 dimer interface [polypeptide binding]; other site 481743002039 ABC-ATPase subunit interface; other site 481743002040 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743002041 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 481743002042 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743002043 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743002044 DNA binding site [nucleotide binding] 481743002045 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 481743002046 putative dimerization interface [polypeptide binding]; other site 481743002047 putative ligand binding site [chemical binding]; other site 481743002048 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 481743002049 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 481743002050 active site 481743002051 substrate binding site [chemical binding]; other site 481743002052 metal binding site [ion binding]; metal-binding site 481743002053 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 481743002054 Part of AAA domain; Region: AAA_19; pfam13245 481743002055 Family description; Region: UvrD_C_2; pfam13538 481743002056 Cold-inducible protein YdjO; Region: YdjO; pfam14169 481743002057 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 481743002058 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 481743002059 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 481743002060 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743002061 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743002062 DNA binding residues [nucleotide binding] 481743002063 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743002064 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 481743002065 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 481743002066 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 481743002067 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 481743002068 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481743002069 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481743002070 metal binding site [ion binding]; metal-binding site 481743002071 active site 481743002072 I-site; other site 481743002073 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 481743002074 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 481743002075 Zn2+ binding site [ion binding]; other site 481743002076 Mg2+ binding site [ion binding]; other site 481743002077 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 481743002078 metal-binding site [ion binding] 481743002079 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 481743002080 dimer interface [polypeptide binding]; other site 481743002081 FMN binding site [chemical binding]; other site 481743002082 NADPH bind site [chemical binding]; other site 481743002083 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743002084 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743002085 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743002086 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743002087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002088 ABC-ATPase subunit interface; other site 481743002089 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743002090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002091 dimer interface [polypeptide binding]; other site 481743002092 conserved gate region; other site 481743002093 putative PBP binding loops; other site 481743002094 ABC-ATPase subunit interface; other site 481743002095 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743002096 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743002097 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 481743002098 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 481743002099 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 481743002100 active site 481743002101 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 481743002102 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 481743002103 Walker A/P-loop; other site 481743002104 ATP binding site [chemical binding]; other site 481743002105 Q-loop/lid; other site 481743002106 ABC transporter signature motif; other site 481743002107 Walker B; other site 481743002108 D-loop; other site 481743002109 H-loop/switch region; other site 481743002110 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 481743002111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002112 dimer interface [polypeptide binding]; other site 481743002113 conserved gate region; other site 481743002114 putative PBP binding loops; other site 481743002115 ABC-ATPase subunit interface; other site 481743002116 Domain of unknown function DUF77; Region: DUF77; pfam01910 481743002117 NMT1/THI5 like; Region: NMT1; pfam09084 481743002118 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743002119 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 481743002120 active site 481743002121 metal binding site [ion binding]; metal-binding site 481743002122 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481743002123 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481743002124 metal binding site [ion binding]; metal-binding site 481743002125 active site 481743002126 I-site; other site 481743002127 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 481743002128 maltose phosphorylase; Provisional; Region: PRK13807 481743002129 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 481743002130 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 481743002131 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 481743002132 beta-phosphoglucomutase; Region: bPGM; TIGR01990 481743002133 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 481743002134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743002135 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 481743002136 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743002137 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743002138 DNA binding site [nucleotide binding] 481743002139 domain linker motif; other site 481743002140 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 481743002141 putative dimerization interface [polypeptide binding]; other site 481743002142 putative ligand binding site [chemical binding]; other site 481743002143 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 481743002144 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 481743002145 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 481743002146 Ca binding site [ion binding]; other site 481743002147 active site 481743002148 catalytic site [active] 481743002149 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743002150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743002151 active site 481743002152 phosphorylation site [posttranslational modification] 481743002153 intermolecular recognition site; other site 481743002154 dimerization interface [polypeptide binding]; other site 481743002155 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743002156 DNA binding site [nucleotide binding] 481743002157 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743002158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743002159 dimer interface [polypeptide binding]; other site 481743002160 phosphorylation site [posttranslational modification] 481743002161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743002162 ATP binding site [chemical binding]; other site 481743002163 Mg2+ binding site [ion binding]; other site 481743002164 G-X-G motif; other site 481743002165 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743002166 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 481743002167 Walker A/P-loop; other site 481743002168 ATP binding site [chemical binding]; other site 481743002169 Q-loop/lid; other site 481743002170 ABC transporter signature motif; other site 481743002171 Walker B; other site 481743002172 D-loop; other site 481743002173 H-loop/switch region; other site 481743002174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 481743002175 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 481743002176 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 481743002177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 481743002178 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743002179 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743002180 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743002181 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743002182 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743002183 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743002184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743002185 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743002186 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743002187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743002188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743002189 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 481743002190 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 481743002191 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 481743002192 Peptidase family U32; Region: Peptidase_U32; pfam01136 481743002193 Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; pfam01729 481743002194 Peptidase family U32; Region: Peptidase_U32; pfam01136 481743002195 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 481743002196 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 481743002197 inhibitor-cofactor binding pocket; inhibition site 481743002198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743002199 catalytic residue [active] 481743002200 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 481743002201 UbiA prenyltransferase family; Region: UbiA; pfam01040 481743002202 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 481743002203 homodimer interface [polypeptide binding]; other site 481743002204 maltodextrin glucosidase; Provisional; Region: PRK10785 481743002205 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 481743002206 active site 481743002207 homodimer interface [polypeptide binding]; other site 481743002208 catalytic site [active] 481743002209 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 481743002210 putative homodimer interface [polypeptide binding]; other site 481743002211 putative homotetramer interface [polypeptide binding]; other site 481743002212 putative metal binding site [ion binding]; other site 481743002213 putative homodimer-homodimer interface [polypeptide binding]; other site 481743002214 putative allosteric switch controlling residues; other site 481743002215 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 481743002216 Prostaglandin dehydrogenases; Region: PGDH; cd05288 481743002217 NAD(P) binding site [chemical binding]; other site 481743002218 substrate binding site [chemical binding]; other site 481743002219 dimer interface [polypeptide binding]; other site 481743002220 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 481743002221 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743002222 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743002223 WHG domain; Region: WHG; pfam13305 481743002224 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 481743002225 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 481743002226 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743002227 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743002228 DNA binding residues [nucleotide binding] 481743002229 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 481743002230 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 481743002231 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743002232 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 481743002233 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 481743002234 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 481743002235 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 481743002236 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481743002237 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 481743002238 substrate binding pocket [chemical binding]; other site 481743002239 membrane-bound complex binding site; other site 481743002240 hinge residues; other site 481743002241 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 481743002242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002243 dimer interface [polypeptide binding]; other site 481743002244 conserved gate region; other site 481743002245 putative PBP binding loops; other site 481743002246 ABC-ATPase subunit interface; other site 481743002247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002248 dimer interface [polypeptide binding]; other site 481743002249 conserved gate region; other site 481743002250 putative PBP binding loops; other site 481743002251 ABC-ATPase subunit interface; other site 481743002252 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 481743002253 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 481743002254 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 481743002255 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 481743002256 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 481743002257 DNA binding residues [nucleotide binding] 481743002258 dimer interface [polypeptide binding]; other site 481743002259 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 481743002260 NADH(P)-binding; Region: NAD_binding_10; pfam13460 481743002261 NAD binding site [chemical binding]; other site 481743002262 putative active site [active] 481743002263 substrate binding site [chemical binding]; other site 481743002264 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 481743002265 Uncharacterized conserved protein [Function unknown]; Region: COG0062 481743002266 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 481743002267 putative substrate binding site [chemical binding]; other site 481743002268 putative ATP binding site [chemical binding]; other site 481743002269 short chain dehydrogenase; Provisional; Region: PRK06701 481743002270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743002271 NAD(P) binding site [chemical binding]; other site 481743002272 active site 481743002273 VanW like protein; Region: VanW; pfam04294 481743002274 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 481743002275 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 481743002276 AAA domain; Region: AAA_33; pfam13671 481743002277 AAA domain; Region: AAA_17; pfam13207 481743002278 Predicted ATPase [General function prediction only]; Region: COG3910 481743002279 ATP-binding cassette domain of non-transporter proteins; Region: ABC_Class2; cd03227 481743002280 Walker A/P-loop; other site 481743002281 ATP binding site [chemical binding]; other site 481743002282 Q-loop/lid; other site 481743002283 ABC transporter signature motif; other site 481743002284 Walker B; other site 481743002285 D-loop; other site 481743002286 H-loop/switch region; other site 481743002287 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481743002288 MarR family; Region: MarR; pfam01047 481743002289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743002290 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743002291 putative substrate translocation pore; other site 481743002292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743002293 Protein of unknown function (DUF817); Region: DUF817; pfam05675 481743002294 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 481743002295 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 481743002296 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 481743002297 homotrimer interaction site [polypeptide binding]; other site 481743002298 putative active site [active] 481743002299 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 481743002300 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 481743002301 dimer interface [polypeptide binding]; other site 481743002302 putative radical transfer pathway; other site 481743002303 diiron center [ion binding]; other site 481743002304 tyrosyl radical; other site 481743002305 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 481743002306 Class I ribonucleotide reductase; Region: RNR_I; cd01679 481743002307 active site 481743002308 dimer interface [polypeptide binding]; other site 481743002309 catalytic residues [active] 481743002310 effector binding site; other site 481743002311 R2 peptide binding site; other site 481743002312 Domain of unknown function DUF77; Region: DUF77; pfam01910 481743002313 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 481743002314 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 481743002315 active site 481743002316 DNA binding site [nucleotide binding] 481743002317 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 481743002318 DNA binding site [nucleotide binding] 481743002319 YolD-like protein; Region: YolD; pfam08863 481743002320 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 481743002321 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 481743002322 RibD C-terminal domain; Region: RibD_C; cl17279 481743002323 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 481743002324 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 481743002325 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 481743002326 Sodium Bile acid symporter family; Region: SBF; cl17470 481743002327 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 481743002328 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 481743002329 active site 481743002330 metal binding site [ion binding]; metal-binding site 481743002331 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743002332 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743002333 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743002334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743002335 Walker A/P-loop; other site 481743002336 ATP binding site [chemical binding]; other site 481743002337 Q-loop/lid; other site 481743002338 ABC transporter signature motif; other site 481743002339 Walker B; other site 481743002340 D-loop; other site 481743002341 H-loop/switch region; other site 481743002342 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743002343 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743002344 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 481743002345 Walker A/P-loop; other site 481743002346 ATP binding site [chemical binding]; other site 481743002347 Q-loop/lid; other site 481743002348 ABC transporter signature motif; other site 481743002349 Walker B; other site 481743002350 D-loop; other site 481743002351 H-loop/switch region; other site 481743002352 Protein of unknown function (DUF664); Region: DUF664; pfam04978 481743002353 DinB superfamily; Region: DinB_2; pfam12867 481743002354 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 481743002355 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 481743002356 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 481743002357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743002358 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 481743002359 Walker A/P-loop; other site 481743002360 ATP binding site [chemical binding]; other site 481743002361 Q-loop/lid; other site 481743002362 ABC transporter signature motif; other site 481743002363 Walker B; other site 481743002364 D-loop; other site 481743002365 H-loop/switch region; other site 481743002366 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 481743002367 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 481743002368 Ca binding site [ion binding]; other site 481743002369 active site 481743002370 catalytic site [active] 481743002371 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 481743002372 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 481743002373 inhibitor binding site; inhibition site 481743002374 catalytic Zn binding site [ion binding]; other site 481743002375 structural Zn binding site [ion binding]; other site 481743002376 NADP binding site [chemical binding]; other site 481743002377 tetramer interface [polypeptide binding]; other site 481743002378 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 481743002379 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743002380 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743002381 DNA binding residues [nucleotide binding] 481743002382 H+ Antiporter protein; Region: 2A0121; TIGR00900 481743002383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743002384 secreted effector protein PipB2; Provisional; Region: PRK15196 481743002385 secreted effector protein PipB2; Provisional; Region: PRK15196 481743002386 HAMP domain; Region: HAMP; pfam00672 481743002387 dimerization interface [polypeptide binding]; other site 481743002388 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 481743002389 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 481743002390 Zn2+ binding site [ion binding]; other site 481743002391 Mg2+ binding site [ion binding]; other site 481743002392 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 481743002393 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 481743002394 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 481743002395 DNA binding residues [nucleotide binding] 481743002396 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 481743002397 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 481743002398 homotrimer interaction site [polypeptide binding]; other site 481743002399 putative active site [active] 481743002400 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 481743002401 CsbD-like; Region: CsbD; cl17424 481743002402 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743002403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743002404 putative substrate translocation pore; other site 481743002405 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 481743002406 NADH(P)-binding; Region: NAD_binding_10; pfam13460 481743002407 NAD binding site [chemical binding]; other site 481743002408 active site 481743002409 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 481743002410 homotrimer interaction site [polypeptide binding]; other site 481743002411 putative active site [active] 481743002412 Response regulator receiver domain; Region: Response_reg; pfam00072 481743002413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743002414 active site 481743002415 phosphorylation site [posttranslational modification] 481743002416 intermolecular recognition site; other site 481743002417 dimerization interface [polypeptide binding]; other site 481743002418 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743002419 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743002420 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743002421 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743002422 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743002423 dimerization interface [polypeptide binding]; other site 481743002424 Histidine kinase; Region: His_kinase; pfam06580 481743002425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743002426 ATP binding site [chemical binding]; other site 481743002427 Mg2+ binding site [ion binding]; other site 481743002428 G-X-G motif; other site 481743002429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002430 dimer interface [polypeptide binding]; other site 481743002431 conserved gate region; other site 481743002432 putative PBP binding loops; other site 481743002433 ABC-ATPase subunit interface; other site 481743002434 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743002435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002436 dimer interface [polypeptide binding]; other site 481743002437 conserved gate region; other site 481743002438 putative PBP binding loops; other site 481743002439 ABC-ATPase subunit interface; other site 481743002440 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743002441 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743002442 SNF2 Helicase protein; Region: DUF3670; pfam12419 481743002443 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 481743002444 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481743002445 ATP binding site [chemical binding]; other site 481743002446 putative Mg++ binding site [ion binding]; other site 481743002447 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481743002448 nucleotide binding region [chemical binding]; other site 481743002449 ATP-binding site [chemical binding]; other site 481743002450 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 481743002451 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 481743002452 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 481743002453 Predicted transcriptional regulators [Transcription]; Region: COG1378 481743002454 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 481743002455 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 481743002456 C-terminal domain interface [polypeptide binding]; other site 481743002457 sugar binding site [chemical binding]; other site 481743002458 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 481743002459 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 481743002460 putative active site [active] 481743002461 putative metal binding site [ion binding]; other site 481743002462 NHL repeat; Region: NHL; pfam01436 481743002463 NHL repeat; Region: NHL; pfam01436 481743002464 NHL repeat; Region: NHL; pfam01436 481743002465 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743002466 FecR protein; Region: FecR; pfam04773 481743002467 Tropomodulin; Region: Tropomodulin; pfam03250 481743002468 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 481743002469 active site 481743002470 xanthine permease; Region: pbuX; TIGR03173 481743002471 Predicted membrane protein [Function unknown]; Region: COG4818 481743002472 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 481743002473 Beta-lactamase; Region: Beta-lactamase; pfam00144 481743002474 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 481743002475 active site 481743002476 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 481743002477 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 481743002478 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 481743002479 Cytochrome c; Region: Cytochrom_C; pfam00034 481743002480 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 481743002481 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 481743002482 D-pathway; other site 481743002483 Putative ubiquinol binding site [chemical binding]; other site 481743002484 Low-spin heme (heme b) binding site [chemical binding]; other site 481743002485 Putative water exit pathway; other site 481743002486 Binuclear center (heme o3/CuB) [ion binding]; other site 481743002487 K-pathway; other site 481743002488 Putative proton exit pathway; other site 481743002489 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 481743002490 Subunit I/III interface [polypeptide binding]; other site 481743002491 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 481743002492 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 481743002493 Protein of unknown function (DUF420); Region: DUF420; pfam04238 481743002494 Predicted transcriptional regulators [Transcription]; Region: COG1725 481743002495 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743002496 DNA-binding site [nucleotide binding]; DNA binding site 481743002497 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743002498 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481743002499 Walker A/P-loop; other site 481743002500 ATP binding site [chemical binding]; other site 481743002501 Q-loop/lid; other site 481743002502 ABC transporter signature motif; other site 481743002503 Walker B; other site 481743002504 D-loop; other site 481743002505 H-loop/switch region; other site 481743002506 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 481743002507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743002508 Walker A/P-loop; other site 481743002509 ATP binding site [chemical binding]; other site 481743002510 Q-loop/lid; other site 481743002511 ABC transporter signature motif; other site 481743002512 Walker B; other site 481743002513 D-loop; other site 481743002514 H-loop/switch region; other site 481743002515 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 481743002516 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 481743002517 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 481743002518 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743002519 TraB family; Region: TraB; pfam01963 481743002520 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 481743002521 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 481743002522 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 481743002523 substrate binding pocket [chemical binding]; other site 481743002524 catalytic triad [active] 481743002525 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743002526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743002527 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 481743002528 dimerization interface [polypeptide binding]; other site 481743002529 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743002530 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743002531 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743002532 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743002533 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 481743002534 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 481743002535 Chromate transporter; Region: Chromate_transp; pfam02417 481743002536 Chromate transporter; Region: Chromate_transp; pfam02417 481743002537 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 481743002538 Sulfatase; Region: Sulfatase; cl17466 481743002539 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743002540 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743002541 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743002542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743002543 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743002544 HAMP domain; Region: HAMP; pfam00672 481743002545 Histidine kinase; Region: His_kinase; pfam06580 481743002546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743002547 ATP binding site [chemical binding]; other site 481743002548 Mg2+ binding site [ion binding]; other site 481743002549 G-X-G motif; other site 481743002550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743002551 active site 481743002552 phosphorylation site [posttranslational modification] 481743002553 intermolecular recognition site; other site 481743002554 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743002555 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743002556 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743002557 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743002558 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743002559 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743002560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002561 conserved gate region; other site 481743002562 ABC-ATPase subunit interface; other site 481743002563 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743002564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002565 dimer interface [polypeptide binding]; other site 481743002566 conserved gate region; other site 481743002567 putative PBP binding loops; other site 481743002568 ABC-ATPase subunit interface; other site 481743002569 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 481743002570 Glycosyl hydrolase family 79, N-terminal domain; Region: Glyco_hydro_79n; pfam03662 481743002571 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 481743002572 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 481743002573 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 481743002574 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 481743002575 Domain of unknown function DUF21; Region: DUF21; pfam01595 481743002576 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 481743002577 Transporter associated domain; Region: CorC_HlyC; smart01091 481743002578 Domain of unknown function DUF21; Region: DUF21; pfam01595 481743002579 FOG: CBS domain [General function prediction only]; Region: COG0517 481743002580 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 481743002581 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 481743002582 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 481743002583 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 481743002584 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 481743002585 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 481743002586 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743002587 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743002588 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 481743002589 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 481743002590 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 481743002591 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 481743002592 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 481743002593 active site 481743002594 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 481743002595 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 481743002596 DNA binding residues [nucleotide binding] 481743002597 dimer interface [polypeptide binding]; other site 481743002598 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 481743002599 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 481743002600 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 481743002601 amino acid carrier protein; Region: agcS; TIGR00835 481743002602 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 481743002603 DinB superfamily; Region: DinB_2; pfam12867 481743002604 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 481743002605 Methyltransferase domain; Region: Methyltransf_23; pfam13489 481743002606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743002607 S-adenosylmethionine binding site [chemical binding]; other site 481743002608 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 481743002609 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 481743002610 Malic enzyme, N-terminal domain; Region: malic; pfam00390 481743002611 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 481743002612 putative NAD(P) binding site [chemical binding]; other site 481743002613 Chitin binding domain; Region: Chitin_bind_3; pfam03067 481743002614 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 481743002615 aromatic chitin/cellulose binding site residues [chemical binding]; other site 481743002616 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 481743002617 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 481743002618 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 481743002619 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 481743002620 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 481743002621 Walker A/P-loop; other site 481743002622 ATP binding site [chemical binding]; other site 481743002623 Q-loop/lid; other site 481743002624 ABC transporter signature motif; other site 481743002625 Walker B; other site 481743002626 D-loop; other site 481743002627 H-loop/switch region; other site 481743002628 TOBE domain; Region: TOBE_2; pfam08402 481743002629 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743002630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002631 dimer interface [polypeptide binding]; other site 481743002632 conserved gate region; other site 481743002633 putative PBP binding loops; other site 481743002634 ABC-ATPase subunit interface; other site 481743002635 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743002636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002637 dimer interface [polypeptide binding]; other site 481743002638 conserved gate region; other site 481743002639 putative PBP binding loops; other site 481743002640 ABC-ATPase subunit interface; other site 481743002641 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743002642 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 481743002643 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 481743002644 Glycerophosphodiester phosphodiesterase domain of putative Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_pAtGDE_like; cd08565 481743002645 active site 481743002646 catalytic site [active] 481743002647 metal binding site [ion binding]; metal-binding site 481743002648 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 481743002649 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 481743002650 active site 481743002651 metal binding site [ion binding]; metal-binding site 481743002652 Cache domain; Region: Cache_1; pfam02743 481743002653 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743002654 dimerization interface [polypeptide binding]; other site 481743002655 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 481743002656 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 481743002657 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 481743002658 dimer interface [polypeptide binding]; other site 481743002659 putative CheW interface [polypeptide binding]; other site 481743002660 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481743002661 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 481743002662 substrate binding pocket [chemical binding]; other site 481743002663 membrane-bound complex binding site; other site 481743002664 hinge residues; other site 481743002665 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743002666 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743002667 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 481743002668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002669 dimer interface [polypeptide binding]; other site 481743002670 conserved gate region; other site 481743002671 putative PBP binding loops; other site 481743002672 ABC-ATPase subunit interface; other site 481743002673 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743002674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002675 dimer interface [polypeptide binding]; other site 481743002676 conserved gate region; other site 481743002677 putative PBP binding loops; other site 481743002678 ABC-ATPase subunit interface; other site 481743002679 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 481743002680 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 481743002681 substrate binding pocket [chemical binding]; other site 481743002682 catalytic triad [active] 481743002683 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743002684 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743002685 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743002686 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743002687 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743002688 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743002689 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743002690 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743002691 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743002692 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 481743002693 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 481743002694 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 481743002695 FtsX-like permease family; Region: FtsX; pfam02687 481743002696 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 481743002697 FtsX-like permease family; Region: FtsX; pfam02687 481743002698 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 481743002699 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 481743002700 Walker A/P-loop; other site 481743002701 ATP binding site [chemical binding]; other site 481743002702 Q-loop/lid; other site 481743002703 ABC transporter signature motif; other site 481743002704 Walker B; other site 481743002705 D-loop; other site 481743002706 H-loop/switch region; other site 481743002707 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743002708 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 481743002709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743002710 ATP binding site [chemical binding]; other site 481743002711 Mg2+ binding site [ion binding]; other site 481743002712 G-X-G motif; other site 481743002713 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743002714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743002715 active site 481743002716 phosphorylation site [posttranslational modification] 481743002717 intermolecular recognition site; other site 481743002718 dimerization interface [polypeptide binding]; other site 481743002719 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743002720 DNA binding site [nucleotide binding] 481743002721 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 481743002722 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 481743002723 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 481743002724 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 481743002725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002726 dimer interface [polypeptide binding]; other site 481743002727 conserved gate region; other site 481743002728 putative PBP binding loops; other site 481743002729 ABC-ATPase subunit interface; other site 481743002730 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 481743002731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002732 putative PBP binding loops; other site 481743002733 dimer interface [polypeptide binding]; other site 481743002734 ABC-ATPase subunit interface; other site 481743002735 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 481743002736 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 481743002737 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 481743002738 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 481743002739 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 481743002740 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481743002741 substrate binding pocket [chemical binding]; other site 481743002742 membrane-bound complex binding site; other site 481743002743 hinge residues; other site 481743002744 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 481743002745 putative FMN binding site [chemical binding]; other site 481743002746 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743002747 dimerization interface [polypeptide binding]; other site 481743002748 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743002749 dimer interface [polypeptide binding]; other site 481743002750 phosphorylation site [posttranslational modification] 481743002751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743002752 ATP binding site [chemical binding]; other site 481743002753 Mg2+ binding site [ion binding]; other site 481743002754 G-X-G motif; other site 481743002755 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743002756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743002757 active site 481743002758 phosphorylation site [posttranslational modification] 481743002759 intermolecular recognition site; other site 481743002760 dimerization interface [polypeptide binding]; other site 481743002761 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743002762 DNA binding site [nucleotide binding] 481743002763 Pirin-related protein [General function prediction only]; Region: COG1741 481743002764 Pirin; Region: Pirin; pfam02678 481743002765 Bacterial SH3 domain; Region: SH3_3; pfam08239 481743002766 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 481743002767 NlpC/P60 family; Region: NLPC_P60; pfam00877 481743002768 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 481743002769 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 481743002770 GAF domain; Region: GAF_2; pfam13185 481743002771 Repressor of nif and glnA expression [Transcription]; Region: COG1693 481743002772 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 481743002773 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 481743002774 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 481743002775 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 481743002776 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 481743002777 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 481743002778 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 481743002779 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 481743002780 Walker A/P-loop; other site 481743002781 ATP binding site [chemical binding]; other site 481743002782 Q-loop/lid; other site 481743002783 ABC transporter signature motif; other site 481743002784 Walker B; other site 481743002785 D-loop; other site 481743002786 H-loop/switch region; other site 481743002787 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 481743002788 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 481743002789 Walker A/P-loop; other site 481743002790 ATP binding site [chemical binding]; other site 481743002791 Q-loop/lid; other site 481743002792 ABC transporter signature motif; other site 481743002793 Walker B; other site 481743002794 D-loop; other site 481743002795 H-loop/switch region; other site 481743002796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743002797 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743002798 putative substrate translocation pore; other site 481743002799 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743002800 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743002801 dimerization interface [polypeptide binding]; other site 481743002802 Histidine kinase; Region: His_kinase; pfam06580 481743002803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743002804 ATP binding site [chemical binding]; other site 481743002805 Mg2+ binding site [ion binding]; other site 481743002806 G-X-G motif; other site 481743002807 Response regulator receiver domain; Region: Response_reg; pfam00072 481743002808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743002809 active site 481743002810 phosphorylation site [posttranslational modification] 481743002811 intermolecular recognition site; other site 481743002812 dimerization interface [polypeptide binding]; other site 481743002813 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743002814 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743002815 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743002816 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743002817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002818 dimer interface [polypeptide binding]; other site 481743002819 conserved gate region; other site 481743002820 ABC-ATPase subunit interface; other site 481743002821 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743002822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 481743002824 ABC-ATPase subunit interface; other site 481743002825 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 481743002826 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 481743002827 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 481743002828 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 481743002829 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 481743002830 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481743002831 MarR family; Region: MarR; pfam01047 481743002832 MarR family; Region: MarR_2; cl17246 481743002833 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 481743002834 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481743002835 Walker A/P-loop; other site 481743002836 ATP binding site [chemical binding]; other site 481743002837 Q-loop/lid; other site 481743002838 ABC transporter signature motif; other site 481743002839 Walker B; other site 481743002840 D-loop; other site 481743002841 H-loop/switch region; other site 481743002842 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 481743002843 HI0933-like protein; Region: HI0933_like; pfam03486 481743002844 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 481743002845 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 481743002846 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481743002847 putative active site [active] 481743002848 heme pocket [chemical binding]; other site 481743002849 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743002850 dimer interface [polypeptide binding]; other site 481743002851 phosphorylation site [posttranslational modification] 481743002852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743002853 ATP binding site [chemical binding]; other site 481743002854 Mg2+ binding site [ion binding]; other site 481743002855 G-X-G motif; other site 481743002856 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 481743002857 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 481743002858 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 481743002859 homodimer interface [polypeptide binding]; other site 481743002860 NAD binding pocket [chemical binding]; other site 481743002861 ATP binding pocket [chemical binding]; other site 481743002862 Mg binding site [ion binding]; other site 481743002863 active-site loop [active] 481743002864 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 481743002865 RibD C-terminal domain; Region: RibD_C; cl17279 481743002866 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 481743002867 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 481743002868 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 481743002869 minor groove reading motif; other site 481743002870 helix-hairpin-helix signature motif; other site 481743002871 substrate binding pocket [chemical binding]; other site 481743002872 active site 481743002873 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 481743002874 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 481743002875 DNA binding and oxoG recognition site [nucleotide binding] 481743002876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743002877 H+ Antiporter protein; Region: 2A0121; TIGR00900 481743002878 putative substrate translocation pore; other site 481743002879 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 481743002880 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 481743002881 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 481743002882 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 481743002883 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 481743002884 Walker A/P-loop; other site 481743002885 ATP binding site [chemical binding]; other site 481743002886 Q-loop/lid; other site 481743002887 ABC transporter signature motif; other site 481743002888 Walker B; other site 481743002889 D-loop; other site 481743002890 H-loop/switch region; other site 481743002891 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 481743002892 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 481743002893 FtsX-like permease family; Region: FtsX; pfam02687 481743002894 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 481743002895 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 481743002896 HlyD family secretion protein; Region: HlyD_3; pfam13437 481743002897 putative acetyltransferase; Provisional; Region: PRK03624 481743002898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743002899 Coenzyme A binding pocket [chemical binding]; other site 481743002900 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 481743002901 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 481743002902 Catalytic site [active] 481743002903 epoxyqueuosine reductase; Region: TIGR00276 481743002904 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 481743002905 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 481743002906 protein binding surface [polypeptide binding]; other site 481743002907 HEAT repeats; Region: HEAT_2; pfam13646 481743002908 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 481743002909 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 481743002910 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 481743002911 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 481743002912 DNA binding site [nucleotide binding] 481743002913 active site 481743002914 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 481743002915 homodecamer interface [polypeptide binding]; other site 481743002916 GTP cyclohydrolase I; Provisional; Region: PLN03044 481743002917 active site 481743002918 putative catalytic site residues [active] 481743002919 zinc binding site [ion binding]; other site 481743002920 GTP-CH-I/GFRP interaction surface; other site 481743002921 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 481743002922 nucleophilic elbow; other site 481743002923 catalytic triad; other site 481743002924 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 481743002925 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 481743002926 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 481743002927 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 481743002928 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 481743002929 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 481743002930 Transcriptional regulator [Transcription]; Region: IclR; COG1414 481743002931 Bacterial transcriptional regulator; Region: IclR; pfam01614 481743002932 aconitate hydratase; Validated; Region: PRK09277 481743002933 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 481743002934 substrate binding site [chemical binding]; other site 481743002935 ligand binding site [chemical binding]; other site 481743002936 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 481743002937 substrate binding site [chemical binding]; other site 481743002938 Putative amidase domain; Region: Amidase_6; pfam12671 481743002939 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 481743002940 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 481743002941 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 481743002942 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 481743002943 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 481743002944 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 481743002945 active site 481743002946 dimerization interface [polypeptide binding]; other site 481743002947 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 481743002948 active site 481743002949 catalytic triad [active] 481743002950 oxyanion hole [active] 481743002951 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743002952 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 481743002953 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 481743002954 transmembrane helices; other site 481743002955 TrkA-C domain; Region: TrkA_C; pfam02080 481743002956 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 481743002957 TrkA-C domain; Region: TrkA_C; pfam02080 481743002958 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 481743002959 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743002960 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 481743002961 Histidine kinase; Region: His_kinase; pfam06580 481743002962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743002963 ATP binding site [chemical binding]; other site 481743002964 Mg2+ binding site [ion binding]; other site 481743002965 G-X-G motif; other site 481743002966 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 481743002967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743002968 active site 481743002969 phosphorylation site [posttranslational modification] 481743002970 intermolecular recognition site; other site 481743002971 dimerization interface [polypeptide binding]; other site 481743002972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743002973 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743002974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002975 dimer interface [polypeptide binding]; other site 481743002976 conserved gate region; other site 481743002977 putative PBP binding loops; other site 481743002978 ABC-ATPase subunit interface; other site 481743002979 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743002980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743002981 dimer interface [polypeptide binding]; other site 481743002982 conserved gate region; other site 481743002983 putative PBP binding loops; other site 481743002984 ABC-ATPase subunit interface; other site 481743002985 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743002986 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743002987 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 481743002988 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 481743002989 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 481743002990 inhibitor-cofactor binding pocket; inhibition site 481743002991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743002992 catalytic residue [active] 481743002993 Transcriptional regulator [Transcription]; Region: LytR; COG1316 481743002994 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 481743002995 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 481743002996 catalytic triad [active] 481743002997 Pirin-related protein [General function prediction only]; Region: COG1741 481743002998 Pirin; Region: Pirin; pfam02678 481743002999 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 481743003000 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 481743003001 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 481743003002 NodB motif; other site 481743003003 active site 481743003004 catalytic site [active] 481743003005 Zn binding site [ion binding]; other site 481743003006 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743003007 Uncharacterized conserved protein [Function unknown]; Region: COG2427 481743003008 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 481743003009 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481743003010 Cache domain; Region: Cache_1; pfam02743 481743003011 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743003012 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743003013 dimerization interface [polypeptide binding]; other site 481743003014 Histidine kinase; Region: His_kinase; pfam06580 481743003015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743003016 ATP binding site [chemical binding]; other site 481743003017 Mg2+ binding site [ion binding]; other site 481743003018 G-X-G motif; other site 481743003019 Response regulator receiver domain; Region: Response_reg; pfam00072 481743003020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743003021 active site 481743003022 phosphorylation site [posttranslational modification] 481743003023 intermolecular recognition site; other site 481743003024 dimerization interface [polypeptide binding]; other site 481743003025 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743003026 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743003027 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743003028 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743003029 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743003030 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743003031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743003032 dimer interface [polypeptide binding]; other site 481743003033 conserved gate region; other site 481743003034 putative PBP binding loops; other site 481743003035 ABC-ATPase subunit interface; other site 481743003036 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743003037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743003038 dimer interface [polypeptide binding]; other site 481743003039 conserved gate region; other site 481743003040 putative PBP binding loops; other site 481743003041 ABC-ATPase subunit interface; other site 481743003042 Response regulator receiver domain; Region: Response_reg; pfam00072 481743003043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743003044 active site 481743003045 phosphorylation site [posttranslational modification] 481743003046 intermolecular recognition site; other site 481743003047 dimerization interface [polypeptide binding]; other site 481743003048 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743003049 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743003050 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743003051 dimerization interface [polypeptide binding]; other site 481743003052 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743003053 Histidine kinase; Region: His_kinase; pfam06580 481743003054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743003055 ATP binding site [chemical binding]; other site 481743003056 Mg2+ binding site [ion binding]; other site 481743003057 G-X-G motif; other site 481743003058 Response regulator receiver domain; Region: Response_reg; pfam00072 481743003059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743003060 active site 481743003061 phosphorylation site [posttranslational modification] 481743003062 intermolecular recognition site; other site 481743003063 dimerization interface [polypeptide binding]; other site 481743003064 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743003065 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743003066 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743003067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743003068 dimer interface [polypeptide binding]; other site 481743003069 conserved gate region; other site 481743003070 putative PBP binding loops; other site 481743003071 ABC-ATPase subunit interface; other site 481743003072 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743003073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743003074 dimer interface [polypeptide binding]; other site 481743003075 conserved gate region; other site 481743003076 ABC-ATPase subunit interface; other site 481743003077 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 481743003078 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 481743003079 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 481743003080 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 481743003081 putative ligand binding site [chemical binding]; other site 481743003082 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 481743003083 Ca binding site [ion binding]; other site 481743003084 carbohydrate binding site [chemical binding]; other site 481743003085 S-layer homology domain; Region: SLH; pfam00395 481743003086 S-layer homology domain; Region: SLH; pfam00395 481743003087 MoxR-like ATPases [General function prediction only]; Region: COG0714 481743003088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743003089 Walker A motif; other site 481743003090 ATP binding site [chemical binding]; other site 481743003091 Walker B motif; other site 481743003092 arginine finger; other site 481743003093 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 481743003094 Protein of unknown function DUF58; Region: DUF58; pfam01882 481743003095 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 481743003096 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 481743003097 GMP synthase; Reviewed; Region: guaA; PRK00074 481743003098 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 481743003099 AMP/PPi binding site [chemical binding]; other site 481743003100 candidate oxyanion hole; other site 481743003101 catalytic triad [active] 481743003102 potential glutamine specificity residues [chemical binding]; other site 481743003103 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 481743003104 ATP Binding subdomain [chemical binding]; other site 481743003105 Ligand Binding sites [chemical binding]; other site 481743003106 Dimerization subdomain; other site 481743003107 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 481743003108 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 481743003109 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 481743003110 dimer interface [polypeptide binding]; other site 481743003111 active site 481743003112 CoA binding pocket [chemical binding]; other site 481743003113 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743003114 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743003115 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743003116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743003117 dimer interface [polypeptide binding]; other site 481743003118 conserved gate region; other site 481743003119 putative PBP binding loops; other site 481743003120 ABC-ATPase subunit interface; other site 481743003121 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743003122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743003123 dimer interface [polypeptide binding]; other site 481743003124 conserved gate region; other site 481743003125 putative PBP binding loops; other site 481743003126 ABC-ATPase subunit interface; other site 481743003127 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743003128 HAMP domain; Region: HAMP; pfam00672 481743003129 Histidine kinase; Region: His_kinase; pfam06580 481743003130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743003131 ATP binding site [chemical binding]; other site 481743003132 Mg2+ binding site [ion binding]; other site 481743003133 G-X-G motif; other site 481743003134 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743003135 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743003136 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 481743003137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743003138 active site 481743003139 phosphorylation site [posttranslational modification] 481743003140 intermolecular recognition site; other site 481743003141 dimerization interface [polypeptide binding]; other site 481743003142 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743003143 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743003144 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743003145 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 481743003146 Zn binding site [ion binding]; other site 481743003147 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 481743003148 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743003149 Zn binding site [ion binding]; other site 481743003150 Predicted transcriptional regulator [Transcription]; Region: COG2378 481743003151 HTH domain; Region: HTH_11; pfam08279 481743003152 WYL domain; Region: WYL; pfam13280 481743003153 short chain dehydrogenase; Provisional; Region: PRK08303 481743003154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743003155 NAD(P) binding site [chemical binding]; other site 481743003156 active site 481743003157 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 481743003158 active site 481743003159 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 481743003160 active site 2 [active] 481743003161 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743003162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743003163 active site 481743003164 phosphorylation site [posttranslational modification] 481743003165 intermolecular recognition site; other site 481743003166 dimerization interface [polypeptide binding]; other site 481743003167 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743003168 DNA binding site [nucleotide binding] 481743003169 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 481743003170 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 481743003171 dimer interface [polypeptide binding]; other site 481743003172 phosphorylation site [posttranslational modification] 481743003173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743003174 ATP binding site [chemical binding]; other site 481743003175 Mg2+ binding site [ion binding]; other site 481743003176 G-X-G motif; other site 481743003177 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 481743003178 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 481743003179 Walker A/P-loop; other site 481743003180 ATP binding site [chemical binding]; other site 481743003181 Q-loop/lid; other site 481743003182 ABC transporter signature motif; other site 481743003183 Walker B; other site 481743003184 D-loop; other site 481743003185 H-loop/switch region; other site 481743003186 FtsX-like permease family; Region: FtsX; pfam02687 481743003187 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 481743003188 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 481743003189 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 481743003190 NADP binding site [chemical binding]; other site 481743003191 dimer interface [polypeptide binding]; other site 481743003192 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 481743003193 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743003194 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743003195 DNA binding residues [nucleotide binding] 481743003196 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 481743003197 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743003198 Coenzyme A binding pocket [chemical binding]; other site 481743003199 Predicted methyltransferases [General function prediction only]; Region: COG1568 481743003200 DNA topoisomerase III; Provisional; Region: PRK07726 481743003201 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 481743003202 active site 481743003203 putative interdomain interaction site [polypeptide binding]; other site 481743003204 putative metal-binding site [ion binding]; other site 481743003205 putative nucleotide binding site [chemical binding]; other site 481743003206 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 481743003207 domain I; other site 481743003208 DNA binding groove [nucleotide binding] 481743003209 phosphate binding site [ion binding]; other site 481743003210 domain II; other site 481743003211 domain III; other site 481743003212 nucleotide binding site [chemical binding]; other site 481743003213 catalytic site [active] 481743003214 domain IV; other site 481743003215 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 481743003216 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 481743003217 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 481743003218 Ligand Binding Site [chemical binding]; other site 481743003219 hypothetical protein; Provisional; Region: PRK06771 481743003220 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 481743003221 catalytic core [active] 481743003222 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 481743003223 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 481743003224 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 481743003225 NAD binding site [chemical binding]; other site 481743003226 ATP-grasp domain; Region: ATP-grasp; pfam02222 481743003227 adenylosuccinate lyase; Provisional; Region: PRK07492 481743003228 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 481743003229 tetramer interface [polypeptide binding]; other site 481743003230 active site 481743003231 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 481743003232 ATP binding site [chemical binding]; other site 481743003233 active site 481743003234 substrate binding site [chemical binding]; other site 481743003235 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 481743003236 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 481743003237 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 481743003238 putative active site [active] 481743003239 catalytic triad [active] 481743003240 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 481743003241 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 481743003242 dimerization interface [polypeptide binding]; other site 481743003243 ATP binding site [chemical binding]; other site 481743003244 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 481743003245 dimerization interface [polypeptide binding]; other site 481743003246 ATP binding site [chemical binding]; other site 481743003247 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 481743003248 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 481743003249 active site 481743003250 tetramer interface [polypeptide binding]; other site 481743003251 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 481743003252 active site 481743003253 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 481743003254 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 481743003255 dimerization interface [polypeptide binding]; other site 481743003256 putative ATP binding site [chemical binding]; other site 481743003257 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 481743003258 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 481743003259 active site 481743003260 substrate binding site [chemical binding]; other site 481743003261 cosubstrate binding site; other site 481743003262 catalytic site [active] 481743003263 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 481743003264 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 481743003265 purine monophosphate binding site [chemical binding]; other site 481743003266 dimer interface [polypeptide binding]; other site 481743003267 putative catalytic residues [active] 481743003268 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 481743003269 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 481743003270 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 481743003271 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 481743003272 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 481743003273 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 481743003274 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743003275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743003276 dimer interface [polypeptide binding]; other site 481743003277 conserved gate region; other site 481743003278 ABC-ATPase subunit interface; other site 481743003279 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743003280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743003281 dimer interface [polypeptide binding]; other site 481743003282 conserved gate region; other site 481743003283 putative PBP binding loops; other site 481743003284 ABC-ATPase subunit interface; other site 481743003285 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743003286 dimerization interface [polypeptide binding]; other site 481743003287 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 481743003288 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 481743003289 dimer interface [polypeptide binding]; other site 481743003290 putative CheW interface [polypeptide binding]; other site 481743003291 Alpha amylase catalytic domain found in maltogenic amylases, cyclodextrin glycosyltransferase, and related proteins; Region: AmyAc_AmyMalt_CGTase_like; cd11320 481743003292 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 481743003293 Ca binding site [ion binding]; other site 481743003294 active site 481743003295 catalytic site [active] 481743003296 Aamy_C domain; Region: Aamy_C; smart00632 481743003297 IPT domain (domain D) of cyclodextrin glycosyltransferase (CGTase) and similar enzymes. These enzymes are involved in the enzymatic hydrolysis of alpha-1,4 linkages of starch polymers and belong to the glycosyl hydrolase family 13. Most consist of three...; Region: IPT_CGTD; cd00604 481743003298 CGTase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. CGTase, also known as cyclodextrin glycosyltransferase and cyclodextrin glucanotransferase, catalyzes the formation of various cyclodextrins (alpha-1,4-glucans) from starch. CGTase...; Region: CBM20_CGTase; cd05807 481743003299 starch-binding site 2 [chemical binding]; other site 481743003300 starch-binding site 1 [chemical binding]; other site 481743003301 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 481743003302 Beta-lactamase; Region: Beta-lactamase; pfam00144 481743003303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743003304 Coenzyme A binding pocket [chemical binding]; other site 481743003305 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743003306 Coenzyme A binding pocket [chemical binding]; other site 481743003307 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 481743003308 Predicted esterase [General function prediction only]; Region: COG0400 481743003309 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 481743003310 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 481743003311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 481743003312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743003313 dimer interface [polypeptide binding]; other site 481743003314 ABC-ATPase subunit interface; other site 481743003315 putative PBP binding loops; other site 481743003316 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743003317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743003318 dimer interface [polypeptide binding]; other site 481743003319 conserved gate region; other site 481743003320 putative PBP binding loops; other site 481743003321 ABC-ATPase subunit interface; other site 481743003322 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743003323 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743003324 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743003325 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743003326 dimerization interface [polypeptide binding]; other site 481743003327 Histidine kinase; Region: His_kinase; pfam06580 481743003328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743003329 ATP binding site [chemical binding]; other site 481743003330 Mg2+ binding site [ion binding]; other site 481743003331 G-X-G motif; other site 481743003332 Response regulator receiver domain; Region: Response_reg; pfam00072 481743003333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743003334 active site 481743003335 phosphorylation site [posttranslational modification] 481743003336 intermolecular recognition site; other site 481743003337 dimerization interface [polypeptide binding]; other site 481743003338 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743003339 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743003340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743003341 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 481743003342 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 481743003343 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 481743003344 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 481743003345 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 481743003346 active site 481743003347 FMN binding site [chemical binding]; other site 481743003348 substrate binding site [chemical binding]; other site 481743003349 putative catalytic residue [active] 481743003350 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743003351 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743003352 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 481743003353 dimerization interface [polypeptide binding]; other site 481743003354 threonine dehydratase; Validated; Region: PRK08639 481743003355 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 481743003356 tetramer interface [polypeptide binding]; other site 481743003357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743003358 catalytic residue [active] 481743003359 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 481743003360 putative Ile/Val binding site [chemical binding]; other site 481743003361 hypothetical protein; Validated; Region: PRK07668 481743003362 Predicted transcriptional regulators [Transcription]; Region: COG1695 481743003363 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 481743003364 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 481743003365 PGAP1-like protein; Region: PGAP1; pfam07819 481743003366 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 481743003367 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 481743003368 putative active site [active] 481743003369 metal binding site [ion binding]; metal-binding site 481743003370 Penicillinase repressor; Region: Pencillinase_R; pfam03965 481743003371 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 481743003372 Predicted membrane protein [Function unknown]; Region: COG2259 481743003373 Predicted membrane protein [Function unknown]; Region: COG2259 481743003374 Predicted membrane protein [Function unknown]; Region: COG2259 481743003375 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743003376 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743003377 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 481743003378 dimerization interface [polypeptide binding]; other site 481743003379 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 481743003380 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 481743003381 NAD(P) binding site [chemical binding]; other site 481743003382 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 481743003383 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 481743003384 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 481743003385 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 481743003386 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 481743003387 oligomer interface [polypeptide binding]; other site 481743003388 metal binding site [ion binding]; metal-binding site 481743003389 metal binding site [ion binding]; metal-binding site 481743003390 putative Cl binding site [ion binding]; other site 481743003391 aspartate ring; other site 481743003392 basic sphincter; other site 481743003393 hydrophobic gate; other site 481743003394 periplasmic entrance; other site 481743003395 YrhK-like protein; Region: YrhK; pfam14145 481743003396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 481743003397 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 481743003398 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 481743003399 putative active site [active] 481743003400 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 481743003401 putative active site [active] 481743003402 putative lipid kinase; Reviewed; Region: PRK13337 481743003403 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 481743003404 TRAM domain; Region: TRAM; pfam01938 481743003405 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 481743003406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743003407 S-adenosylmethionine binding site [chemical binding]; other site 481743003408 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 481743003409 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR4; cd08270 481743003410 putative NAD(P) binding site [chemical binding]; other site 481743003411 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 481743003412 Beta/Gamma crystallin; Region: Crystall; cl02528 481743003413 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 481743003414 N-acetyl-D-glucosamine binding site [chemical binding]; other site 481743003415 catalytic residue [active] 481743003416 hybrid cluster protein; Provisional; Region: PRK05290 481743003417 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 481743003418 ACS interaction site; other site 481743003419 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 481743003420 hybrid metal cluster; other site 481743003421 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 481743003422 pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028 481743003423 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 481743003424 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674 481743003425 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 481743003426 dimer interface [polypeptide binding]; other site 481743003427 PYR/PP interface [polypeptide binding]; other site 481743003428 TPP binding site [chemical binding]; other site 481743003429 substrate binding site [chemical binding]; other site 481743003430 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 481743003431 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 481743003432 TPP-binding site [chemical binding]; other site 481743003433 putative dimer interface [polypeptide binding]; other site 481743003434 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743003435 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743003436 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743003437 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 481743003438 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743003439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743003440 dimer interface [polypeptide binding]; other site 481743003441 conserved gate region; other site 481743003442 putative PBP binding loops; other site 481743003443 ABC-ATPase subunit interface; other site 481743003444 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743003445 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743003446 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 481743003447 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 481743003448 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 481743003449 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 481743003450 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 481743003451 FMN binding site [chemical binding]; other site 481743003452 active site 481743003453 catalytic residues [active] 481743003454 substrate binding site [chemical binding]; other site 481743003455 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 481743003456 substrate binding site [chemical binding]; other site 481743003457 THF binding site; other site 481743003458 zinc-binding site [ion binding]; other site 481743003459 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 481743003460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743003461 putative substrate translocation pore; other site 481743003462 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743003463 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743003464 Predicted ATPase [General function prediction only]; Region: COG3910 481743003465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743003466 Walker A/P-loop; other site 481743003467 ATP binding site [chemical binding]; other site 481743003468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743003469 Walker B; other site 481743003470 D-loop; other site 481743003471 H-loop/switch region; other site 481743003472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743003473 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743003474 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 481743003475 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 481743003476 Na binding site [ion binding]; other site 481743003477 Protein of unknown function (DUF917); Region: DUF917; pfam06032 481743003478 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 481743003479 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 481743003480 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 481743003481 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 481743003482 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 481743003483 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 481743003484 Walker A/P-loop; other site 481743003485 ATP binding site [chemical binding]; other site 481743003486 Q-loop/lid; other site 481743003487 ABC transporter signature motif; other site 481743003488 Walker B; other site 481743003489 D-loop; other site 481743003490 H-loop/switch region; other site 481743003491 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 481743003492 FtsX-like permease family; Region: FtsX; pfam02687 481743003493 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 481743003494 FtsX-like permease family; Region: FtsX; pfam02687 481743003495 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743003496 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743003497 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 481743003498 hypothetical protein; Provisional; Region: PRK06761 481743003499 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 481743003500 E-class dimer interface [polypeptide binding]; other site 481743003501 P-class dimer interface [polypeptide binding]; other site 481743003502 active site 481743003503 Cu2+ binding site [ion binding]; other site 481743003504 Zn2+ binding site [ion binding]; other site 481743003505 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743003506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743003507 dimer interface [polypeptide binding]; other site 481743003508 putative PBP binding loops; other site 481743003509 ABC-ATPase subunit interface; other site 481743003510 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743003511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743003512 dimer interface [polypeptide binding]; other site 481743003513 conserved gate region; other site 481743003514 putative PBP binding loops; other site 481743003515 ABC-ATPase subunit interface; other site 481743003516 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 481743003517 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743003518 Histidine kinase; Region: His_kinase; pfam06580 481743003519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743003520 ATP binding site [chemical binding]; other site 481743003521 Mg2+ binding site [ion binding]; other site 481743003522 G-X-G motif; other site 481743003523 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743003524 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743003525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743003526 Response regulator receiver domain; Region: Response_reg; pfam00072 481743003527 active site 481743003528 phosphorylation site [posttranslational modification] 481743003529 intermolecular recognition site; other site 481743003530 dimerization interface [polypeptide binding]; other site 481743003531 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743003532 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743003533 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743003534 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 481743003535 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 481743003536 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 481743003537 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 481743003538 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 481743003539 DEAD/DEAH box helicase; Region: DEAD; pfam00270 481743003540 DEAD/DEAH box helicase; Region: DEAD; pfam00270 481743003541 putative Mg++ binding site [ion binding]; other site 481743003542 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 481743003543 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 481743003544 HsdM N-terminal domain; Region: HsdM_N; pfam12161 481743003545 Methyltransferase domain; Region: Methyltransf_26; pfam13659 481743003546 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 481743003547 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 481743003548 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 481743003549 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 481743003550 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 481743003551 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 481743003552 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481743003553 ATP binding site [chemical binding]; other site 481743003554 putative Mg++ binding site [ion binding]; other site 481743003555 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481743003556 nucleotide binding region [chemical binding]; other site 481743003557 ATP-binding site [chemical binding]; other site 481743003558 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 481743003559 metal binding site [ion binding]; metal-binding site 481743003560 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 481743003561 active site 481743003562 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 481743003563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 481743003564 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 481743003565 Protein of unknown function (DUF524); Region: DUF524; pfam04411 481743003566 Nuclease-related domain; Region: NERD; pfam08378 481743003567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481743003568 non-specific DNA binding site [nucleotide binding]; other site 481743003569 salt bridge; other site 481743003570 sequence-specific DNA binding site [nucleotide binding]; other site 481743003571 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 481743003572 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481743003573 membrane-bound complex binding site; other site 481743003574 hinge residues; other site 481743003575 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 481743003576 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 481743003577 active site 481743003578 dimer interface [polypeptide binding]; other site 481743003579 non-prolyl cis peptide bond; other site 481743003580 insertion regions; other site 481743003581 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 481743003582 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481743003583 substrate binding pocket [chemical binding]; other site 481743003584 membrane-bound complex binding site; other site 481743003585 hinge residues; other site 481743003586 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 481743003587 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 481743003588 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 481743003589 Walker A/P-loop; other site 481743003590 ATP binding site [chemical binding]; other site 481743003591 Q-loop/lid; other site 481743003592 ABC transporter signature motif; other site 481743003593 Walker B; other site 481743003594 D-loop; other site 481743003595 H-loop/switch region; other site 481743003596 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 481743003597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743003598 dimer interface [polypeptide binding]; other site 481743003599 conserved gate region; other site 481743003600 putative PBP binding loops; other site 481743003601 ABC-ATPase subunit interface; other site 481743003602 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 481743003603 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743003604 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743003605 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743003606 xanthine permease; Region: pbuX; TIGR03173 481743003607 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 481743003608 guanine deaminase; Region: guan_deamin; TIGR02967 481743003609 active site 481743003610 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 481743003611 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 481743003612 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 481743003613 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 481743003614 active site 481743003615 active site 481743003616 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 481743003617 S-layer homology domain; Region: SLH; pfam00395 481743003618 S-layer homology domain; Region: SLH; pfam00395 481743003619 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 481743003620 Response regulator receiver domain; Region: Response_reg; pfam00072 481743003621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743003622 active site 481743003623 phosphorylation site [posttranslational modification] 481743003624 intermolecular recognition site; other site 481743003625 dimerization interface [polypeptide binding]; other site 481743003626 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743003627 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743003628 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743003629 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743003630 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743003631 dimerization interface [polypeptide binding]; other site 481743003632 Histidine kinase; Region: His_kinase; pfam06580 481743003633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743003634 ATP binding site [chemical binding]; other site 481743003635 Mg2+ binding site [ion binding]; other site 481743003636 G-X-G motif; other site 481743003637 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 481743003638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743003639 dimer interface [polypeptide binding]; other site 481743003640 conserved gate region; other site 481743003641 putative PBP binding loops; other site 481743003642 ABC-ATPase subunit interface; other site 481743003643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743003644 dimer interface [polypeptide binding]; other site 481743003645 conserved gate region; other site 481743003646 ABC-ATPase subunit interface; other site 481743003647 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 481743003648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743003649 Walker A/P-loop; other site 481743003650 ATP binding site [chemical binding]; other site 481743003651 Q-loop/lid; other site 481743003652 ABC transporter signature motif; other site 481743003653 Walker B; other site 481743003654 D-loop; other site 481743003655 H-loop/switch region; other site 481743003656 TOBE domain; Region: TOBE_2; pfam08402 481743003657 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 481743003658 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 481743003659 Penicillinase repressor; Region: Pencillinase_R; pfam03965 481743003660 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 481743003661 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 481743003662 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743003663 FeS/SAM binding site; other site 481743003664 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 481743003665 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 481743003666 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 481743003667 ATP binding site [chemical binding]; other site 481743003668 Mg++ binding site [ion binding]; other site 481743003669 motif III; other site 481743003670 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481743003671 nucleotide binding region [chemical binding]; other site 481743003672 ATP-binding site [chemical binding]; other site 481743003673 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 481743003674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743003675 S-adenosylmethionine binding site [chemical binding]; other site 481743003676 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 481743003677 Predicted membrane protein [Function unknown]; Region: COG3212 481743003678 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 481743003679 nudix motif; other site 481743003680 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 481743003681 nudix motif; other site 481743003682 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 481743003683 catalytic core [active] 481743003684 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743003685 putative DNA binding site [nucleotide binding]; other site 481743003686 dimerization interface [polypeptide binding]; other site 481743003687 putative Zn2+ binding site [ion binding]; other site 481743003688 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 481743003689 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 481743003690 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743003691 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743003692 DNA binding residues [nucleotide binding] 481743003693 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 481743003694 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743003695 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 481743003696 active site 481743003697 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 481743003698 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 481743003699 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743003700 FeS/SAM binding site; other site 481743003701 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 481743003702 active site 481743003703 catalytic triad [active] 481743003704 oxyanion hole [active] 481743003705 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743003706 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743003707 DNA binding site [nucleotide binding] 481743003708 domain linker motif; other site 481743003709 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 481743003710 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743003711 Cache domain; Region: Cache_1; pfam02743 481743003712 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743003713 dimerization interface [polypeptide binding]; other site 481743003714 Histidine kinase; Region: His_kinase; pfam06580 481743003715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743003716 ATP binding site [chemical binding]; other site 481743003717 Mg2+ binding site [ion binding]; other site 481743003718 G-X-G motif; other site 481743003719 Response regulator receiver domain; Region: Response_reg; pfam00072 481743003720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743003721 active site 481743003722 phosphorylation site [posttranslational modification] 481743003723 intermolecular recognition site; other site 481743003724 dimerization interface [polypeptide binding]; other site 481743003725 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743003726 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743003727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743003728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743003729 dimer interface [polypeptide binding]; other site 481743003730 conserved gate region; other site 481743003731 putative PBP binding loops; other site 481743003732 ABC-ATPase subunit interface; other site 481743003733 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743003734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743003735 dimer interface [polypeptide binding]; other site 481743003736 conserved gate region; other site 481743003737 putative PBP binding loops; other site 481743003738 ABC-ATPase subunit interface; other site 481743003739 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 481743003740 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743003741 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 481743003742 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 481743003743 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743003744 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743003745 DNA binding residues [nucleotide binding] 481743003746 dimerization interface [polypeptide binding]; other site 481743003747 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 481743003748 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 481743003749 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 481743003750 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 481743003751 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 481743003752 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 481743003753 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 481743003754 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 481743003755 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 481743003756 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 481743003757 S-layer homology domain; Region: SLH; pfam00395 481743003758 S-layer homology domain; Region: SLH; pfam00395 481743003759 S-layer homology domain; Region: SLH; pfam00395 481743003760 SEC-C motif; Region: SEC-C; pfam02810 481743003761 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 481743003762 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 481743003763 Walker A/P-loop; other site 481743003764 ATP binding site [chemical binding]; other site 481743003765 Q-loop/lid; other site 481743003766 ABC transporter signature motif; other site 481743003767 Walker B; other site 481743003768 D-loop; other site 481743003769 H-loop/switch region; other site 481743003770 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 481743003771 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481743003772 ABC-ATPase subunit interface; other site 481743003773 dimer interface [polypeptide binding]; other site 481743003774 putative PBP binding regions; other site 481743003775 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 481743003776 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481743003777 ABC-ATPase subunit interface; other site 481743003778 dimer interface [polypeptide binding]; other site 481743003779 putative PBP binding regions; other site 481743003780 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 481743003781 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 481743003782 siderophore binding site; other site 481743003783 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 481743003784 putative dimer interface [polypeptide binding]; other site 481743003785 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743003786 Putative transcription activator [Transcription]; Region: TenA; COG0819 481743003787 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 481743003788 substrate binding site [chemical binding]; other site 481743003789 multimerization interface [polypeptide binding]; other site 481743003790 ATP binding site [chemical binding]; other site 481743003791 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 481743003792 dimer interface [polypeptide binding]; other site 481743003793 substrate binding site [chemical binding]; other site 481743003794 ATP binding site [chemical binding]; other site 481743003795 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 481743003796 ATP binding site [chemical binding]; other site 481743003797 substrate binding site [chemical binding]; other site 481743003798 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 481743003799 thiamine phosphate binding site [chemical binding]; other site 481743003800 active site 481743003801 pyrophosphate binding site [ion binding]; other site 481743003802 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 481743003803 HTH domain; Region: HTH_11; pfam08279 481743003804 Mga helix-turn-helix domain; Region: Mga; pfam05043 481743003805 PRD domain; Region: PRD; pfam00874 481743003806 PRD domain; Region: PRD; pfam00874 481743003807 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 481743003808 active site 481743003809 P-loop; other site 481743003810 phosphorylation site [posttranslational modification] 481743003811 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 481743003812 active site 481743003813 phosphorylation site [posttranslational modification] 481743003814 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 481743003815 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 481743003816 active site 481743003817 P-loop; other site 481743003818 phosphorylation site [posttranslational modification] 481743003819 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 481743003820 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 481743003821 active site 481743003822 phosphorylation site [posttranslational modification] 481743003823 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 481743003824 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 481743003825 Predicted transcriptional regulators [Transcription]; Region: COG1695 481743003826 Transcriptional regulator PadR-like family; Region: PadR; cl17335 481743003827 methionine sulfoxide reductase A; Provisional; Region: PRK14054 481743003828 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 481743003829 SelR domain; Region: SelR; pfam01641 481743003830 Phosphotransferase enzyme family; Region: APH; pfam01636 481743003831 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743003832 active site 481743003833 ATP binding site [chemical binding]; other site 481743003834 substrate binding site [chemical binding]; other site 481743003835 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 481743003836 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 481743003837 ligand binding site [chemical binding]; other site 481743003838 flexible hinge region; other site 481743003839 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 481743003840 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 481743003841 ligand binding site [chemical binding]; other site 481743003842 flexible hinge region; other site 481743003843 Protease prsW family; Region: PrsW-protease; pfam13367 481743003844 Double zinc ribbon; Region: DZR; pfam12773 481743003845 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 481743003846 Major royal jelly protein; Region: MRJP; pfam03022 481743003847 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 481743003848 pyruvate kinase; Provisional; Region: PRK05826 481743003849 domain interfaces; other site 481743003850 active site 481743003851 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743003852 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743003853 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743003854 Transcriptional regulator [Transcription]; Region: LytR; COG1316 481743003855 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 481743003856 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 481743003857 DNA binding residues [nucleotide binding] 481743003858 dimer interface [polypeptide binding]; other site 481743003859 General stress protein [General function prediction only]; Region: GsiB; COG3729 481743003860 Predicted transcriptional regulators [Transcription]; Region: COG1733 481743003861 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 481743003862 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481743003863 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481743003864 active site 481743003865 catalytic tetrad [active] 481743003866 Phage Tail Collar Domain; Region: Collar; pfam07484 481743003867 Phage Tail Collar Domain; Region: Collar; pfam07484 481743003868 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 481743003869 Bacterial Ig-like domain; Region: Big_5; pfam13205 481743003870 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 481743003871 Interdomain contacts; other site 481743003872 Cytokine receptor motif; other site 481743003873 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 481743003874 S-layer homology domain; Region: SLH; pfam00395 481743003875 S-layer homology domain; Region: SLH; pfam00395 481743003876 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481743003877 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481743003878 active site 481743003879 catalytic tetrad [active] 481743003880 DinB superfamily; Region: DinB_2; pfam12867 481743003881 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 481743003882 putative active site; other site 481743003883 putative metal binding residues [ion binding]; other site 481743003884 signature motif; other site 481743003885 putative triphosphate binding site [ion binding]; other site 481743003886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 481743003887 YheO-like PAS domain; Region: PAS_6; pfam08348 481743003888 HTH domain; Region: HTH_22; pfam13309 481743003889 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 481743003890 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743003891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743003892 homodimer interface [polypeptide binding]; other site 481743003893 catalytic residue [active] 481743003894 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 481743003895 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 481743003896 homotrimer interaction site [polypeptide binding]; other site 481743003897 putative active site [active] 481743003898 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 481743003899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 481743003900 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 481743003901 putative sugar binding site [chemical binding]; other site 481743003902 catalytic residues [active] 481743003903 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 481743003904 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 481743003905 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 481743003906 Walker A motif; other site 481743003907 ATP binding site [chemical binding]; other site 481743003908 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743003909 DNA binding residues [nucleotide binding] 481743003910 dimerization interface [polypeptide binding]; other site 481743003911 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 481743003912 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 481743003913 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 481743003914 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 481743003915 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 481743003916 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 481743003917 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 481743003918 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 481743003919 Bacterial Ig-like domain; Region: Big_5; pfam13205 481743003920 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 481743003921 S-layer homology domain; Region: SLH; pfam00395 481743003922 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 481743003923 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 481743003924 ligand binding site [chemical binding]; other site 481743003925 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 481743003926 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 481743003927 Walker A/P-loop; other site 481743003928 ATP binding site [chemical binding]; other site 481743003929 Q-loop/lid; other site 481743003930 ABC transporter signature motif; other site 481743003931 Walker B; other site 481743003932 D-loop; other site 481743003933 H-loop/switch region; other site 481743003934 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 481743003935 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481743003936 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 481743003937 TM-ABC transporter signature motif; other site 481743003938 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481743003939 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 481743003940 TM-ABC transporter signature motif; other site 481743003941 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 481743003942 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 481743003943 Moco binding site; other site 481743003944 metal coordination site [ion binding]; other site 481743003945 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 481743003946 DinB family; Region: DinB; cl17821 481743003947 DinB superfamily; Region: DinB_2; pfam12867 481743003948 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743003949 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743003950 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 481743003951 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 481743003952 putative NAD(P) binding site [chemical binding]; other site 481743003953 putative active site [active] 481743003954 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 481743003955 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743003956 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743003957 DNA binding residues [nucleotide binding] 481743003958 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743003959 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743003960 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 481743003961 Trehalase; Region: Trehalase; cl17346 481743003962 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743003963 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743003964 dimerization interface [polypeptide binding]; other site 481743003965 Histidine kinase; Region: His_kinase; pfam06580 481743003966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743003967 ATP binding site [chemical binding]; other site 481743003968 Mg2+ binding site [ion binding]; other site 481743003969 G-X-G motif; other site 481743003970 Response regulator receiver domain; Region: Response_reg; pfam00072 481743003971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743003972 active site 481743003973 phosphorylation site [posttranslational modification] 481743003974 intermolecular recognition site; other site 481743003975 dimerization interface [polypeptide binding]; other site 481743003976 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743003977 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743003978 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743003979 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743003980 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743003981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743003982 dimer interface [polypeptide binding]; other site 481743003983 conserved gate region; other site 481743003984 ABC-ATPase subunit interface; other site 481743003985 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743003986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743003987 dimer interface [polypeptide binding]; other site 481743003988 conserved gate region; other site 481743003989 putative PBP binding loops; other site 481743003990 ABC-ATPase subunit interface; other site 481743003991 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 481743003992 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 481743003993 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 481743003994 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 481743003995 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 481743003996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743003997 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743003998 putative substrate translocation pore; other site 481743003999 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743004000 heat shock protein 90; Provisional; Region: PRK05218 481743004001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743004002 ATP binding site [chemical binding]; other site 481743004003 Mg2+ binding site [ion binding]; other site 481743004004 G-X-G motif; other site 481743004005 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 481743004006 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 481743004007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743004008 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743004009 putative substrate translocation pore; other site 481743004010 Predicted transcriptional regulators [Transcription]; Region: COG1695 481743004011 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 481743004012 Predicted transcriptional regulators [Transcription]; Region: COG1733 481743004013 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 481743004014 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 481743004015 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 481743004016 Response regulator receiver domain; Region: Response_reg; pfam00072 481743004017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743004018 active site 481743004019 phosphorylation site [posttranslational modification] 481743004020 intermolecular recognition site; other site 481743004021 dimerization interface [polypeptide binding]; other site 481743004022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743004023 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743004024 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 481743004025 Histidine kinase; Region: His_kinase; pfam06580 481743004026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743004027 ATP binding site [chemical binding]; other site 481743004028 Mg2+ binding site [ion binding]; other site 481743004029 G-X-G motif; other site 481743004030 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743004031 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743004032 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743004033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004034 dimer interface [polypeptide binding]; other site 481743004035 conserved gate region; other site 481743004036 putative PBP binding loops; other site 481743004037 ABC-ATPase subunit interface; other site 481743004038 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743004039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004040 dimer interface [polypeptide binding]; other site 481743004041 conserved gate region; other site 481743004042 putative PBP binding loops; other site 481743004043 ABC-ATPase subunit interface; other site 481743004044 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 481743004045 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743004046 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743004047 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743004048 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743004049 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743004050 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743004051 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 481743004052 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 481743004053 active site 481743004054 trimer interface [polypeptide binding]; other site 481743004055 allosteric site; other site 481743004056 active site lid [active] 481743004057 hexamer (dimer of trimers) interface [polypeptide binding]; other site 481743004058 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 481743004059 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 481743004060 active site 481743004061 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 481743004062 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 481743004063 trimer interface [polypeptide binding]; other site 481743004064 active site 481743004065 substrate binding site [chemical binding]; other site 481743004066 CoA binding site [chemical binding]; other site 481743004067 Predicted transcriptional regulator [Transcription]; Region: COG2378 481743004068 HTH domain; Region: HTH_11; pfam08279 481743004069 WYL domain; Region: WYL; pfam13280 481743004070 DinB family; Region: DinB; cl17821 481743004071 DinB superfamily; Region: DinB_2; pfam12867 481743004072 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 481743004073 Pathogenicity locus; Region: Cdd1; pfam11731 481743004074 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 481743004075 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 481743004076 Erythromycin esterase; Region: Erythro_esteras; cl17110 481743004077 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481743004078 non-specific DNA binding site [nucleotide binding]; other site 481743004079 salt bridge; other site 481743004080 sequence-specific DNA binding site [nucleotide binding]; other site 481743004081 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 481743004082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743004083 S-adenosylmethionine binding site [chemical binding]; other site 481743004084 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743004085 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 481743004086 dimer interface [polypeptide binding]; other site 481743004087 S-layer homology domain; Region: SLH; pfam00395 481743004088 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 481743004089 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743004090 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743004091 DNA binding site [nucleotide binding] 481743004092 domain linker motif; other site 481743004093 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 481743004094 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743004095 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743004096 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743004097 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 481743004098 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 481743004099 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743004100 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743004101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004102 dimer interface [polypeptide binding]; other site 481743004103 conserved gate region; other site 481743004104 putative PBP binding loops; other site 481743004105 ABC-ATPase subunit interface; other site 481743004106 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743004107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004108 dimer interface [polypeptide binding]; other site 481743004109 conserved gate region; other site 481743004110 putative PBP binding loops; other site 481743004111 ABC-ATPase subunit interface; other site 481743004112 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743004113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004114 dimer interface [polypeptide binding]; other site 481743004115 ABC-ATPase subunit interface; other site 481743004116 putative PBP binding loops; other site 481743004117 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743004118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004119 dimer interface [polypeptide binding]; other site 481743004120 conserved gate region; other site 481743004121 ABC-ATPase subunit interface; other site 481743004122 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 481743004123 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 481743004124 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 481743004125 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 481743004126 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 481743004127 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 481743004128 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 481743004129 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 481743004130 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 481743004131 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 481743004132 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 481743004133 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 481743004134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004135 dimer interface [polypeptide binding]; other site 481743004136 conserved gate region; other site 481743004137 putative PBP binding loops; other site 481743004138 ABC-ATPase subunit interface; other site 481743004139 Tumour suppressor, Mitostatin; Region: Trichoplein; pfam13868 481743004140 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 481743004141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004142 dimer interface [polypeptide binding]; other site 481743004143 conserved gate region; other site 481743004144 putative PBP binding loops; other site 481743004145 ABC-ATPase subunit interface; other site 481743004146 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 481743004147 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743004148 Walker A/P-loop; other site 481743004149 ATP binding site [chemical binding]; other site 481743004150 Q-loop/lid; other site 481743004151 ABC transporter signature motif; other site 481743004152 Walker B; other site 481743004153 D-loop; other site 481743004154 H-loop/switch region; other site 481743004155 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 481743004156 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743004157 Walker A/P-loop; other site 481743004158 ATP binding site [chemical binding]; other site 481743004159 Q-loop/lid; other site 481743004160 ABC transporter signature motif; other site 481743004161 Walker B; other site 481743004162 D-loop; other site 481743004163 H-loop/switch region; other site 481743004164 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 481743004165 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 481743004166 active site 481743004167 catalytic triad [active] 481743004168 oxyanion hole [active] 481743004169 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 481743004170 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 481743004171 putative ligand binding site [chemical binding]; other site 481743004172 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 481743004173 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 481743004174 Walker A/P-loop; other site 481743004175 ATP binding site [chemical binding]; other site 481743004176 Q-loop/lid; other site 481743004177 ABC transporter signature motif; other site 481743004178 Walker B; other site 481743004179 D-loop; other site 481743004180 H-loop/switch region; other site 481743004181 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 481743004182 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 481743004183 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481743004184 TM-ABC transporter signature motif; other site 481743004185 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 481743004186 active site 481743004187 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743004188 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743004189 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 481743004190 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 481743004191 putative di-iron ligands [ion binding]; other site 481743004192 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 481743004193 Nucleoside transporter; Region: Nucleoside_tran; cl15430 481743004194 Histidine kinase; Region: HisKA_3; pfam07730 481743004195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743004196 ATP binding site [chemical binding]; other site 481743004197 Mg2+ binding site [ion binding]; other site 481743004198 G-X-G motif; other site 481743004199 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743004200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743004201 active site 481743004202 phosphorylation site [posttranslational modification] 481743004203 intermolecular recognition site; other site 481743004204 dimerization interface [polypeptide binding]; other site 481743004205 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743004206 DNA binding residues [nucleotide binding] 481743004207 dimerization interface [polypeptide binding]; other site 481743004208 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 481743004209 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 481743004210 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 481743004211 TrkA-C domain; Region: TrkA_C; pfam02080 481743004212 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 481743004213 classical (c) SDRs; Region: SDR_c; cd05233 481743004214 NAD(P) binding site [chemical binding]; other site 481743004215 active site 481743004216 Methyltransferase domain; Region: Methyltransf_31; pfam13847 481743004217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743004218 S-adenosylmethionine binding site [chemical binding]; other site 481743004219 Acyltransferase family; Region: Acyl_transf_3; pfam01757 481743004220 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 481743004221 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743004222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743004223 active site 481743004224 phosphorylation site [posttranslational modification] 481743004225 intermolecular recognition site; other site 481743004226 dimerization interface [polypeptide binding]; other site 481743004227 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743004228 DNA binding site [nucleotide binding] 481743004229 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 481743004230 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743004231 dimerization interface [polypeptide binding]; other site 481743004232 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743004233 dimerization interface [polypeptide binding]; other site 481743004234 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743004235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743004236 dimer interface [polypeptide binding]; other site 481743004237 phosphorylation site [posttranslational modification] 481743004238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743004239 ATP binding site [chemical binding]; other site 481743004240 Mg2+ binding site [ion binding]; other site 481743004241 G-X-G motif; other site 481743004242 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 481743004243 Trp docking motif [polypeptide binding]; other site 481743004244 active site 481743004245 PQQ-like domain; Region: PQQ_2; pfam13360 481743004246 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743004247 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743004248 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743004249 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743004250 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743004251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004252 dimer interface [polypeptide binding]; other site 481743004253 conserved gate region; other site 481743004254 putative PBP binding loops; other site 481743004255 ABC-ATPase subunit interface; other site 481743004256 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743004257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004258 dimer interface [polypeptide binding]; other site 481743004259 conserved gate region; other site 481743004260 putative PBP binding loops; other site 481743004261 ABC-ATPase subunit interface; other site 481743004262 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 481743004263 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743004264 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 481743004265 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 481743004266 iron-sulfur cluster [ion binding]; other site 481743004267 [2Fe-2S] cluster binding site [ion binding]; other site 481743004268 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 481743004269 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 481743004270 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 481743004271 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743004272 putative DNA binding site [nucleotide binding]; other site 481743004273 putative Zn2+ binding site [ion binding]; other site 481743004274 AsnC family; Region: AsnC_trans_reg; pfam01037 481743004275 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 481743004276 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 481743004277 putative active site [active] 481743004278 putative metal binding site [ion binding]; other site 481743004279 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 481743004280 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 481743004281 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 481743004282 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 481743004283 Interdomain contacts; other site 481743004284 Cytokine receptor motif; other site 481743004285 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 481743004286 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 481743004287 active site 481743004288 metal binding site [ion binding]; metal-binding site 481743004289 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 481743004290 S-layer homology domain; Region: SLH; pfam00395 481743004291 S-layer homology domain; Region: SLH; pfam00395 481743004292 S-layer homology domain; Region: SLH; pfam00395 481743004293 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 481743004294 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743004295 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743004296 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 481743004297 Bacterial Ig-like domain 2; Region: BID_2; smart00635 481743004298 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 481743004299 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 481743004300 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 481743004301 Uncharacterized conserved protein [Function unknown]; Region: COG0398 481743004302 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 481743004303 Predicted membrane protein [Function unknown]; Region: COG3428 481743004304 Bacterial PH domain; Region: DUF304; pfam03703 481743004305 Bacterial PH domain; Region: DUF304; pfam03703 481743004306 Bacterial PH domain; Region: DUF304; cl01348 481743004307 Predicted transcriptional regulator [Transcription]; Region: COG2378 481743004308 HTH domain; Region: HTH_11; pfam08279 481743004309 WYL domain; Region: WYL; pfam13280 481743004310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 481743004311 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 481743004312 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 481743004313 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743004314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004315 dimer interface [polypeptide binding]; other site 481743004316 conserved gate region; other site 481743004317 putative PBP binding loops; other site 481743004318 ABC-ATPase subunit interface; other site 481743004319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004320 dimer interface [polypeptide binding]; other site 481743004321 conserved gate region; other site 481743004322 putative PBP binding loops; other site 481743004323 ABC-ATPase subunit interface; other site 481743004324 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743004325 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743004326 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743004327 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743004328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743004329 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 481743004330 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743004331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743004332 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743004333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004334 dimer interface [polypeptide binding]; other site 481743004335 conserved gate region; other site 481743004336 ABC-ATPase subunit interface; other site 481743004337 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743004338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004339 dimer interface [polypeptide binding]; other site 481743004340 conserved gate region; other site 481743004341 putative PBP binding loops; other site 481743004342 ABC-ATPase subunit interface; other site 481743004343 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743004344 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743004345 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 481743004346 active site 481743004347 catalytic residues [active] 481743004348 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743004349 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743004350 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743004351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004352 dimer interface [polypeptide binding]; other site 481743004353 conserved gate region; other site 481743004354 putative PBP binding loops; other site 481743004355 ABC-ATPase subunit interface; other site 481743004356 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743004357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004358 dimer interface [polypeptide binding]; other site 481743004359 conserved gate region; other site 481743004360 putative PBP binding loops; other site 481743004361 ABC-ATPase subunit interface; other site 481743004362 PBP superfamily domain; Region: PBP_like_2; cl17296 481743004363 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743004364 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743004365 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743004366 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743004367 Putative Ig domain; Region: He_PIG; pfam05345 481743004368 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 481743004369 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 481743004370 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 481743004371 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 481743004372 active site 481743004373 metal binding site [ion binding]; metal-binding site 481743004374 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 481743004375 S-layer homology domain; Region: SLH; pfam00395 481743004376 S-layer homology domain; Region: SLH; pfam00395 481743004377 S-layer homology domain; Region: SLH; pfam00395 481743004378 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743004379 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743004380 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 481743004381 dimerization interface [polypeptide binding]; other site 481743004382 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 481743004383 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 481743004384 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 481743004385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004386 dimer interface [polypeptide binding]; other site 481743004387 conserved gate region; other site 481743004388 putative PBP binding loops; other site 481743004389 ABC-ATPase subunit interface; other site 481743004390 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 481743004391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004392 dimer interface [polypeptide binding]; other site 481743004393 conserved gate region; other site 481743004394 putative PBP binding loops; other site 481743004395 ABC-ATPase subunit interface; other site 481743004396 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 481743004397 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743004398 Walker A/P-loop; other site 481743004399 ATP binding site [chemical binding]; other site 481743004400 Q-loop/lid; other site 481743004401 ABC transporter signature motif; other site 481743004402 Walker B; other site 481743004403 D-loop; other site 481743004404 H-loop/switch region; other site 481743004405 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 481743004406 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 481743004407 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743004408 Walker A/P-loop; other site 481743004409 ATP binding site [chemical binding]; other site 481743004410 Q-loop/lid; other site 481743004411 ABC transporter signature motif; other site 481743004412 Walker B; other site 481743004413 D-loop; other site 481743004414 H-loop/switch region; other site 481743004415 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 481743004416 glutamate carboxypeptidase; Reviewed; Region: PRK06133 481743004417 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 481743004418 metal binding site [ion binding]; metal-binding site 481743004419 dimer interface [polypeptide binding]; other site 481743004420 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 481743004421 ATP-grasp domain; Region: ATP-grasp_4; cl17255 481743004422 EamA-like transporter family; Region: EamA; pfam00892 481743004423 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 481743004424 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 481743004425 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743004426 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 481743004427 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743004428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004429 dimer interface [polypeptide binding]; other site 481743004430 conserved gate region; other site 481743004431 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 481743004432 ABC-ATPase subunit interface; other site 481743004433 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743004434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004435 dimer interface [polypeptide binding]; other site 481743004436 ABC-ATPase subunit interface; other site 481743004437 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743004438 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743004439 Uncharacterized conserved protein [Function unknown]; Region: COG0327 481743004440 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 481743004441 Transcriptional regulators [Transcription]; Region: GntR; COG1802 481743004442 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743004443 DNA-binding site [nucleotide binding]; DNA binding site 481743004444 FCD domain; Region: FCD; pfam07729 481743004445 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 481743004446 SpoOM protein; Region: Spo0M; pfam07070 481743004447 TRAM domain; Region: TRAM; pfam01938 481743004448 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 481743004449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743004450 S-adenosylmethionine binding site [chemical binding]; other site 481743004451 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 481743004452 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 481743004453 5S rRNA interface [nucleotide binding]; other site 481743004454 CTC domain interface [polypeptide binding]; other site 481743004455 L16 interface [polypeptide binding]; other site 481743004456 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 481743004457 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 481743004458 Uncharacterized conserved protein [Function unknown]; Region: COG5646 481743004459 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 481743004460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743004461 Coenzyme A binding pocket [chemical binding]; other site 481743004462 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 481743004463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743004464 S-adenosylmethionine binding site [chemical binding]; other site 481743004465 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 481743004466 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 481743004467 DNA binding residues [nucleotide binding] 481743004468 putative dimer interface [polypeptide binding]; other site 481743004469 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 481743004470 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 481743004471 catalytic residues [active] 481743004472 PAS domain S-box; Region: sensory_box; TIGR00229 481743004473 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481743004474 putative active site [active] 481743004475 heme pocket [chemical binding]; other site 481743004476 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 481743004477 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481743004478 putative active site [active] 481743004479 heme pocket [chemical binding]; other site 481743004480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743004481 dimer interface [polypeptide binding]; other site 481743004482 phosphorylation site [posttranslational modification] 481743004483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743004484 ATP binding site [chemical binding]; other site 481743004485 Mg2+ binding site [ion binding]; other site 481743004486 G-X-G motif; other site 481743004487 Response regulator receiver domain; Region: Response_reg; pfam00072 481743004488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743004489 active site 481743004490 phosphorylation site [posttranslational modification] 481743004491 intermolecular recognition site; other site 481743004492 dimerization interface [polypeptide binding]; other site 481743004493 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 481743004494 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 481743004495 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 481743004496 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743004497 Proline dehydrogenase; Region: Pro_dh; cl03282 481743004498 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743004499 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743004500 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743004501 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743004502 dimerization interface [polypeptide binding]; other site 481743004503 putative DNA binding site [nucleotide binding]; other site 481743004504 putative Zn2+ binding site [ion binding]; other site 481743004505 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 481743004506 putative hydrophobic ligand binding site [chemical binding]; other site 481743004507 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 481743004508 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 481743004509 active site 481743004510 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 481743004511 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 481743004512 Walker A/P-loop; other site 481743004513 ATP binding site [chemical binding]; other site 481743004514 Q-loop/lid; other site 481743004515 ABC transporter signature motif; other site 481743004516 Walker B; other site 481743004517 D-loop; other site 481743004518 H-loop/switch region; other site 481743004519 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 481743004520 Tropomyosin like; Region: Tropomyosin_1; pfam12718 481743004521 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 481743004522 FtsX-like permease family; Region: FtsX; pfam02687 481743004523 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 481743004524 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 481743004525 FtsX-like permease family; Region: FtsX; pfam02687 481743004526 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743004527 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743004528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743004529 Walker A/P-loop; other site 481743004530 ATP binding site [chemical binding]; other site 481743004531 Q-loop/lid; other site 481743004532 ABC transporter signature motif; other site 481743004533 Walker B; other site 481743004534 D-loop; other site 481743004535 H-loop/switch region; other site 481743004536 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743004537 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743004538 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 481743004539 Walker A/P-loop; other site 481743004540 ATP binding site [chemical binding]; other site 481743004541 Q-loop/lid; other site 481743004542 ABC transporter signature motif; other site 481743004543 Walker B; other site 481743004544 D-loop; other site 481743004545 H-loop/switch region; other site 481743004546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743004547 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743004548 putative substrate translocation pore; other site 481743004549 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743004550 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743004551 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 481743004552 dimerization interface [polypeptide binding]; other site 481743004553 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 481743004554 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 481743004555 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 481743004556 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 481743004557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743004558 Walker A/P-loop; other site 481743004559 ATP binding site [chemical binding]; other site 481743004560 Q-loop/lid; other site 481743004561 ABC transporter signature motif; other site 481743004562 Walker B; other site 481743004563 D-loop; other site 481743004564 H-loop/switch region; other site 481743004565 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743004566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743004567 active site 481743004568 phosphorylation site [posttranslational modification] 481743004569 intermolecular recognition site; other site 481743004570 dimerization interface [polypeptide binding]; other site 481743004571 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743004572 DNA binding site [nucleotide binding] 481743004573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743004574 binding surface 481743004575 TPR motif; other site 481743004576 TPR repeat; Region: TPR_11; pfam13414 481743004577 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743004578 binding surface 481743004579 TPR motif; other site 481743004580 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743004581 binding surface 481743004582 Tetratricopeptide repeat; Region: TPR_16; pfam13432 481743004583 TPR motif; other site 481743004584 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743004585 binding surface 481743004586 Tetratricopeptide repeat; Region: TPR_16; pfam13432 481743004587 TPR motif; other site 481743004588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743004589 binding surface 481743004590 TPR motif; other site 481743004591 TPR repeat; Region: TPR_11; pfam13414 481743004592 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743004593 TPR motif; other site 481743004594 binding surface 481743004595 TPR repeat; Region: TPR_11; pfam13414 481743004596 TPR repeat; Region: TPR_11; pfam13414 481743004597 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 481743004598 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 481743004599 Walker A/P-loop; other site 481743004600 ATP binding site [chemical binding]; other site 481743004601 Q-loop/lid; other site 481743004602 ABC transporter signature motif; other site 481743004603 Walker B; other site 481743004604 D-loop; other site 481743004605 H-loop/switch region; other site 481743004606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004607 dimer interface [polypeptide binding]; other site 481743004608 conserved gate region; other site 481743004609 ABC-ATPase subunit interface; other site 481743004610 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 481743004611 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 481743004612 peptidase T; Region: peptidase-T; TIGR01882 481743004613 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 481743004614 metal binding site [ion binding]; metal-binding site 481743004615 dimer interface [polypeptide binding]; other site 481743004616 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743004617 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743004618 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743004619 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743004620 alpha-galactosidase; Provisional; Region: PRK15076 481743004621 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 481743004622 NAD binding site [chemical binding]; other site 481743004623 sugar binding site [chemical binding]; other site 481743004624 divalent metal binding site [ion binding]; other site 481743004625 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 481743004626 dimer interface [polypeptide binding]; other site 481743004627 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 481743004628 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743004629 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743004630 dimer interface [polypeptide binding]; other site 481743004631 phosphorylation site [posttranslational modification] 481743004632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743004633 ATP binding site [chemical binding]; other site 481743004634 Mg2+ binding site [ion binding]; other site 481743004635 G-X-G motif; other site 481743004636 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 481743004637 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 481743004638 substrate binding site [chemical binding]; other site 481743004639 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 481743004640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004641 dimer interface [polypeptide binding]; other site 481743004642 conserved gate region; other site 481743004643 putative PBP binding loops; other site 481743004644 ABC-ATPase subunit interface; other site 481743004645 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 481743004646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004647 dimer interface [polypeptide binding]; other site 481743004648 conserved gate region; other site 481743004649 putative PBP binding loops; other site 481743004650 ABC-ATPase subunit interface; other site 481743004651 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 481743004652 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743004653 Walker A/P-loop; other site 481743004654 ATP binding site [chemical binding]; other site 481743004655 Q-loop/lid; other site 481743004656 ABC transporter signature motif; other site 481743004657 Walker B; other site 481743004658 D-loop; other site 481743004659 H-loop/switch region; other site 481743004660 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 481743004661 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743004662 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 481743004663 Walker A/P-loop; other site 481743004664 ATP binding site [chemical binding]; other site 481743004665 Q-loop/lid; other site 481743004666 ABC transporter signature motif; other site 481743004667 Walker B; other site 481743004668 D-loop; other site 481743004669 H-loop/switch region; other site 481743004670 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 481743004671 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481743004672 putative active site [active] 481743004673 PAS fold; Region: PAS_3; pfam08447 481743004674 heme pocket [chemical binding]; other site 481743004675 PAS domain S-box; Region: sensory_box; TIGR00229 481743004676 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481743004677 putative active site [active] 481743004678 heme pocket [chemical binding]; other site 481743004679 PAS domain; Region: PAS; smart00091 481743004680 PAS domain S-box; Region: sensory_box; TIGR00229 481743004681 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 481743004682 Histidine kinase; Region: HisKA_3; pfam07730 481743004683 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743004684 ATP binding site [chemical binding]; other site 481743004685 Mg2+ binding site [ion binding]; other site 481743004686 G-X-G motif; other site 481743004687 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743004688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743004689 active site 481743004690 phosphorylation site [posttranslational modification] 481743004691 intermolecular recognition site; other site 481743004692 dimerization interface [polypeptide binding]; other site 481743004693 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743004694 DNA binding residues [nucleotide binding] 481743004695 dimerization interface [polypeptide binding]; other site 481743004696 Cache domain; Region: Cache_1; pfam02743 481743004697 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 481743004698 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 481743004699 dimerization interface [polypeptide binding]; other site 481743004700 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 481743004701 dimer interface [polypeptide binding]; other site 481743004702 putative CheW interface [polypeptide binding]; other site 481743004703 Cupin domain; Region: Cupin_2; pfam07883 481743004704 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743004705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743004706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743004707 alpha-galactosidase; Provisional; Region: PRK15076 481743004708 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 481743004709 NAD binding site [chemical binding]; other site 481743004710 sugar binding site [chemical binding]; other site 481743004711 divalent metal binding site [ion binding]; other site 481743004712 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 481743004713 dimer interface [polypeptide binding]; other site 481743004714 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 481743004715 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 481743004716 hexamer interface [polypeptide binding]; other site 481743004717 ligand binding site [chemical binding]; other site 481743004718 putative active site [active] 481743004719 NAD(P) binding site [chemical binding]; other site 481743004720 Repair protein; Region: Repair_PSII; pfam04536 481743004721 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 481743004722 hypothetical protein; Provisional; Region: PRK13660 481743004723 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 481743004724 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743004725 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743004726 DNA binding residues [nucleotide binding] 481743004727 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 481743004728 active site 481743004729 SUMO-1 interface [polypeptide binding]; other site 481743004730 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 481743004731 hypothetical protein; Provisional; Region: PRK08236 481743004732 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743004733 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743004734 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 481743004735 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 481743004736 ligand binding site [chemical binding]; other site 481743004737 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743004738 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743004739 dimerization interface [polypeptide binding]; other site 481743004740 Histidine kinase; Region: His_kinase; pfam06580 481743004741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743004742 ATP binding site [chemical binding]; other site 481743004743 Mg2+ binding site [ion binding]; other site 481743004744 G-X-G motif; other site 481743004745 Response regulator receiver domain; Region: Response_reg; pfam00072 481743004746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743004747 active site 481743004748 phosphorylation site [posttranslational modification] 481743004749 intermolecular recognition site; other site 481743004750 dimerization interface [polypeptide binding]; other site 481743004751 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743004752 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743004753 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 481743004754 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 481743004755 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 481743004756 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 481743004757 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 481743004758 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 481743004759 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 481743004760 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 481743004761 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 481743004762 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 481743004763 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 481743004764 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 481743004765 S-layer homology domain; Region: SLH; pfam00395 481743004766 S-layer homology domain; Region: SLH; pfam00395 481743004767 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 481743004768 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 481743004769 putative ligand binding site [chemical binding]; other site 481743004770 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 481743004771 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 481743004772 Walker A/P-loop; other site 481743004773 ATP binding site [chemical binding]; other site 481743004774 Q-loop/lid; other site 481743004775 ABC transporter signature motif; other site 481743004776 Walker B; other site 481743004777 D-loop; other site 481743004778 H-loop/switch region; other site 481743004779 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 481743004780 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481743004781 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 481743004782 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 481743004783 TM-ABC transporter signature motif; other site 481743004784 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743004785 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481743004786 Walker A/P-loop; other site 481743004787 ATP binding site [chemical binding]; other site 481743004788 Q-loop/lid; other site 481743004789 ABC transporter signature motif; other site 481743004790 Walker B; other site 481743004791 D-loop; other site 481743004792 H-loop/switch region; other site 481743004793 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743004794 DNA-binding site [nucleotide binding]; DNA binding site 481743004795 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 481743004796 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 481743004797 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 481743004798 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 481743004799 putative active site [active] 481743004800 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 481743004801 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 481743004802 nucleotide binding site [chemical binding]; other site 481743004803 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743004804 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 481743004805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004806 dimer interface [polypeptide binding]; other site 481743004807 conserved gate region; other site 481743004808 putative PBP binding loops; other site 481743004809 ABC-ATPase subunit interface; other site 481743004810 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743004811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743004812 dimer interface [polypeptide binding]; other site 481743004813 conserved gate region; other site 481743004814 putative PBP binding loops; other site 481743004815 ABC-ATPase subunit interface; other site 481743004816 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 481743004817 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 481743004818 putative active site cavity [active] 481743004819 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 481743004820 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743004821 dimerization interface [polypeptide binding]; other site 481743004822 putative DNA binding site [nucleotide binding]; other site 481743004823 putative Zn2+ binding site [ion binding]; other site 481743004824 H+ Antiporter protein; Region: 2A0121; TIGR00900 481743004825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743004826 putative substrate translocation pore; other site 481743004827 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 481743004828 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743004829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743004830 homodimer interface [polypeptide binding]; other site 481743004831 catalytic residue [active] 481743004832 Membrane transport protein; Region: Mem_trans; cl09117 481743004833 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 481743004834 classical (c) SDRs; Region: SDR_c; cd05233 481743004835 NAD(P) binding site [chemical binding]; other site 481743004836 active site 481743004837 hypothetical protein; Provisional; Region: PRK06922 481743004838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743004839 S-adenosylmethionine binding site [chemical binding]; other site 481743004840 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 481743004841 active site 481743004842 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 481743004843 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 481743004844 Sulfate transporter family; Region: Sulfate_transp; pfam00916 481743004845 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 481743004846 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 481743004847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743004848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743004849 dimer interface [polypeptide binding]; other site 481743004850 phosphorylation site [posttranslational modification] 481743004851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743004852 ATP binding site [chemical binding]; other site 481743004853 Mg2+ binding site [ion binding]; other site 481743004854 G-X-G motif; other site 481743004855 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743004856 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743004857 dimer interface [polypeptide binding]; other site 481743004858 phosphorylation site [posttranslational modification] 481743004859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743004860 ATP binding site [chemical binding]; other site 481743004861 Mg2+ binding site [ion binding]; other site 481743004862 G-X-G motif; other site 481743004863 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 481743004864 Heat induced stress protein YflT; Region: YflT; pfam11181 481743004865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743004866 Coenzyme A binding pocket [chemical binding]; other site 481743004867 potassium/proton antiporter; Reviewed; Region: PRK05326 481743004868 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 481743004869 TrkA-C domain; Region: TrkA_C; pfam02080 481743004870 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 481743004871 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 481743004872 dimerization interface [polypeptide binding]; other site 481743004873 DPS ferroxidase diiron center [ion binding]; other site 481743004874 ion pore; other site 481743004875 EcsC protein family; Region: EcsC; pfam12787 481743004876 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 481743004877 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 481743004878 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743004879 FeS/SAM binding site; other site 481743004880 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 481743004881 active site 481743004882 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 481743004883 Ligand Binding Site [chemical binding]; other site 481743004884 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 481743004885 Protein of unknown function (DUF904); Region: DUF904; pfam06005 481743004886 HTH domain; Region: HTH_11; pfam08279 481743004887 S-layer homology domain; Region: SLH; pfam00395 481743004888 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 481743004889 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 481743004890 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 481743004891 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 481743004892 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 481743004893 active site 481743004894 multicopper oxidase; Provisional; Region: PRK10965 481743004895 Phosphotransferase enzyme family; Region: APH; pfam01636 481743004896 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743004897 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 481743004898 Phosphotransferase enzyme family; Region: APH; pfam01636 481743004899 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743004900 active site 481743004901 ATP binding site [chemical binding]; other site 481743004902 FkbH-like domain; Region: FkbH; TIGR01686 481743004903 Acid Phosphatase; Region: Acid_PPase; cl17256 481743004904 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 481743004905 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 481743004906 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 481743004907 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 481743004908 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 481743004909 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 481743004910 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 481743004911 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 481743004912 Probable Catalytic site; other site 481743004913 metal-binding site 481743004914 Protein of unknown function (DUF616); Region: DUF616; pfam04765 481743004915 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743004916 active site 481743004917 substrate binding site [chemical binding]; other site 481743004918 ATP binding site [chemical binding]; other site 481743004919 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 481743004920 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 481743004921 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 481743004922 Ligand binding site; other site 481743004923 Putative Catalytic site; other site 481743004924 DXD motif; other site 481743004925 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 481743004926 active site 481743004927 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 481743004928 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 481743004929 Probable Catalytic site; other site 481743004930 metal-binding site 481743004931 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 481743004932 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 481743004933 active site 481743004934 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 481743004935 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 481743004936 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 481743004937 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 481743004938 Probable Catalytic site; other site 481743004939 metal-binding site 481743004940 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 481743004941 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 481743004942 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 481743004943 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 481743004944 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 481743004945 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 481743004946 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 481743004947 inhibitor-cofactor binding pocket; inhibition site 481743004948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743004949 catalytic residue [active] 481743004950 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 481743004951 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 481743004952 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 481743004953 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 481743004954 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 481743004955 NAD binding site [chemical binding]; other site 481743004956 substrate binding site [chemical binding]; other site 481743004957 homodimer interface [polypeptide binding]; other site 481743004958 active site 481743004959 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 481743004960 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 481743004961 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 481743004962 active site 481743004963 dimer interface [polypeptide binding]; other site 481743004964 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 481743004965 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 481743004966 active site 481743004967 trimer interface [polypeptide binding]; other site 481743004968 allosteric site; other site 481743004969 active site lid [active] 481743004970 hexamer (dimer of trimers) interface [polypeptide binding]; other site 481743004971 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 481743004972 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 481743004973 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 481743004974 putative active site [active] 481743004975 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743004976 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743004977 DNA binding residues [nucleotide binding] 481743004978 dimerization interface [polypeptide binding]; other site 481743004979 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 481743004980 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743004981 Histidine kinase; Region: His_kinase; pfam06580 481743004982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743004983 ATP binding site [chemical binding]; other site 481743004984 Mg2+ binding site [ion binding]; other site 481743004985 G-X-G motif; other site 481743004986 Response regulator receiver domain; Region: Response_reg; pfam00072 481743004987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743004988 active site 481743004989 phosphorylation site [posttranslational modification] 481743004990 intermolecular recognition site; other site 481743004991 dimerization interface [polypeptide binding]; other site 481743004992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743004993 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743004994 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743004995 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743004996 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743004997 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 481743004998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 481743004999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743005000 putative PBP binding loops; other site 481743005001 dimer interface [polypeptide binding]; other site 481743005002 ABC-ATPase subunit interface; other site 481743005003 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743005004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743005005 dimer interface [polypeptide binding]; other site 481743005006 conserved gate region; other site 481743005007 putative PBP binding loops; other site 481743005008 ABC-ATPase subunit interface; other site 481743005009 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 481743005010 Nucleoside recognition; Region: Gate; pfam07670 481743005011 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 481743005012 Nucleoside recognition; Region: Gate; pfam07670 481743005013 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 481743005014 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 481743005015 G1 box; other site 481743005016 GTP/Mg2+ binding site [chemical binding]; other site 481743005017 Switch I region; other site 481743005018 G2 box; other site 481743005019 G3 box; other site 481743005020 Switch II region; other site 481743005021 G4 box; other site 481743005022 G5 box; other site 481743005023 FeoA domain; Region: FeoA; pfam04023 481743005024 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 481743005025 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743005026 dimerization interface [polypeptide binding]; other site 481743005027 putative DNA binding site [nucleotide binding]; other site 481743005028 putative Zn2+ binding site [ion binding]; other site 481743005029 prolyl-tRNA synthetase; Provisional; Region: PRK09194 481743005030 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 481743005031 dimer interface [polypeptide binding]; other site 481743005032 motif 1; other site 481743005033 active site 481743005034 motif 2; other site 481743005035 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 481743005036 putative deacylase active site [active] 481743005037 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 481743005038 active site 481743005039 motif 3; other site 481743005040 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 481743005041 anticodon binding site; other site 481743005042 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 481743005043 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 481743005044 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 481743005045 ligand binding site; other site 481743005046 oligomer interface; other site 481743005047 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 481743005048 dimer interface [polypeptide binding]; other site 481743005049 N-terminal domain interface [polypeptide binding]; other site 481743005050 sulfate 1 binding site; other site 481743005051 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 481743005052 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 481743005053 ligand binding site; other site 481743005054 oligomer interface; other site 481743005055 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 481743005056 dimer interface [polypeptide binding]; other site 481743005057 N-terminal domain interface [polypeptide binding]; other site 481743005058 sulfate 1 binding site; other site 481743005059 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 481743005060 homodimer interface [polypeptide binding]; other site 481743005061 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 481743005062 active site pocket [active] 481743005063 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 481743005064 tetramer interfaces [polypeptide binding]; other site 481743005065 binuclear metal-binding site [ion binding]; other site 481743005066 Spore germination protein [General function prediction only]; Region: COG5401 481743005067 Sporulation and spore germination; Region: Germane; pfam10646 481743005068 Sporulation and spore germination; Region: Germane; pfam10646 481743005069 ribonuclease PH; Reviewed; Region: rph; PRK00173 481743005070 Ribonuclease PH; Region: RNase_PH_bact; cd11362 481743005071 hexamer interface [polypeptide binding]; other site 481743005072 active site 481743005073 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 481743005074 active site 481743005075 dimerization interface [polypeptide binding]; other site 481743005076 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 481743005077 active site 481743005078 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 481743005079 dimer interface [polypeptide binding]; other site 481743005080 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 481743005081 Ligand Binding Site [chemical binding]; other site 481743005082 Molecular Tunnel; other site 481743005083 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743005084 Tic20-like protein; Region: Tic20; pfam09685 481743005085 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 481743005086 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743005087 Coenzyme A binding pocket [chemical binding]; other site 481743005088 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 481743005089 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 481743005090 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 481743005091 active site 481743005092 HIGH motif; other site 481743005093 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 481743005094 tRNA binding surface [nucleotide binding]; other site 481743005095 anticodon binding site; other site 481743005096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743005097 S-adenosylmethionine binding site [chemical binding]; other site 481743005098 Predicted membrane protein [Function unknown]; Region: COG2510 481743005099 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 481743005100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743005101 Coenzyme A binding pocket [chemical binding]; other site 481743005102 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481743005103 ATP binding site [chemical binding]; other site 481743005104 DEAD-like helicases superfamily; Region: DEXDc; smart00487 481743005105 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 481743005106 putative Mg++ binding site [ion binding]; other site 481743005107 helicase superfamily c-terminal domain; Region: HELICc; smart00490 481743005108 trigger factor; Provisional; Region: tig; PRK01490 481743005109 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 481743005110 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 481743005111 Clp protease; Region: CLP_protease; pfam00574 481743005112 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 481743005113 oligomer interface [polypeptide binding]; other site 481743005114 active site residues [active] 481743005115 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 481743005116 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 481743005117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743005118 Walker A motif; other site 481743005119 ATP binding site [chemical binding]; other site 481743005120 Walker B motif; other site 481743005121 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 481743005122 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 481743005123 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 481743005124 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 481743005125 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 481743005126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743005127 Walker A motif; other site 481743005128 ATP binding site [chemical binding]; other site 481743005129 Walker B motif; other site 481743005130 arginine finger; other site 481743005131 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 481743005132 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 481743005133 Found in ATP-dependent protease La (LON); Region: LON; smart00464 481743005134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743005135 Walker A motif; other site 481743005136 ATP binding site [chemical binding]; other site 481743005137 Walker B motif; other site 481743005138 arginine finger; other site 481743005139 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 481743005140 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 481743005141 G1 box; other site 481743005142 GTP/Mg2+ binding site [chemical binding]; other site 481743005143 Switch I region; other site 481743005144 G2 box; other site 481743005145 G3 box; other site 481743005146 Switch II region; other site 481743005147 G4 box; other site 481743005148 G5 box; other site 481743005149 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 481743005150 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 481743005151 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 481743005152 tRNA; other site 481743005153 putative tRNA binding site [nucleotide binding]; other site 481743005154 putative NADP binding site [chemical binding]; other site 481743005155 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 481743005156 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 481743005157 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 481743005158 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 481743005159 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 481743005160 domain interfaces; other site 481743005161 active site 481743005162 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 481743005163 active site 481743005164 SAM binding site [chemical binding]; other site 481743005165 homodimer interface [polypeptide binding]; other site 481743005166 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 481743005167 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 481743005168 active site 481743005169 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 481743005170 dimer interface [polypeptide binding]; other site 481743005171 active site 481743005172 Schiff base residues; other site 481743005173 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 481743005174 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 481743005175 inhibitor-cofactor binding pocket; inhibition site 481743005176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743005177 catalytic residue [active] 481743005178 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 481743005179 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 481743005180 active site 481743005181 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 481743005182 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 481743005183 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 481743005184 active site 481743005185 HIGH motif; other site 481743005186 nucleotide binding site [chemical binding]; other site 481743005187 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 481743005188 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 481743005189 active site 481743005190 KMSKS motif; other site 481743005191 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 481743005192 tRNA binding surface [nucleotide binding]; other site 481743005193 anticodon binding site; other site 481743005194 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 481743005195 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 481743005196 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 481743005197 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 481743005198 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 481743005199 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 481743005200 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 481743005201 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 481743005202 Sporulation related domain; Region: SPOR; pfam05036 481743005203 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 481743005204 Maf-like protein; Reviewed; Region: PRK00078 481743005205 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 481743005206 active site 481743005207 dimer interface [polypeptide binding]; other site 481743005208 hypothetical protein; Reviewed; Region: PRK00024 481743005209 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 481743005210 MPN+ (JAMM) motif; other site 481743005211 Zinc-binding site [ion binding]; other site 481743005212 rod shape-determining protein MreB; Provisional; Region: PRK13927 481743005213 MreB and similar proteins; Region: MreB_like; cd10225 481743005214 nucleotide binding site [chemical binding]; other site 481743005215 Mg binding site [ion binding]; other site 481743005216 putative protofilament interaction site [polypeptide binding]; other site 481743005217 RodZ interaction site [polypeptide binding]; other site 481743005218 rod shape-determining protein MreC; Provisional; Region: PRK13922 481743005219 rod shape-determining protein MreC; Region: MreC; pfam04085 481743005220 rod shape-determining protein MreD; Region: MreD; cl01087 481743005221 septum formation inhibitor; Reviewed; Region: minC; PRK00513 481743005222 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 481743005223 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 481743005224 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 481743005225 Switch I; other site 481743005226 Switch II; other site 481743005227 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 481743005228 Peptidase family M23; Region: Peptidase_M23; pfam01551 481743005229 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 481743005230 Peptidase family M50; Region: Peptidase_M50; pfam02163 481743005231 active site 481743005232 putative substrate binding region [chemical binding]; other site 481743005233 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 481743005234 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 481743005235 homodimer interface [polypeptide binding]; other site 481743005236 oligonucleotide binding site [chemical binding]; other site 481743005237 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 481743005238 Protein of unknown function (DUF464); Region: DUF464; pfam04327 481743005239 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 481743005240 GTPase CgtA; Reviewed; Region: obgE; PRK12297 481743005241 GTP1/OBG; Region: GTP1_OBG; pfam01018 481743005242 Obg GTPase; Region: Obg; cd01898 481743005243 G1 box; other site 481743005244 GTP/Mg2+ binding site [chemical binding]; other site 481743005245 Switch I region; other site 481743005246 G2 box; other site 481743005247 G3 box; other site 481743005248 Switch II region; other site 481743005249 G4 box; other site 481743005250 G5 box; other site 481743005251 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 481743005252 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 481743005253 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 481743005254 Double zinc ribbon; Region: DZR; pfam12773 481743005255 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 481743005256 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 481743005257 Double zinc ribbon; Region: DZR; pfam12773 481743005258 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 481743005259 FlxA-like protein; Region: FlxA; pfam14282 481743005260 hypothetical protein; Provisional; Region: PRK04435 481743005261 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 481743005262 homoserine dehydrogenase; Provisional; Region: PRK06349 481743005263 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 481743005264 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 481743005265 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 481743005266 threonine synthase; Reviewed; Region: PRK06721 481743005267 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 481743005268 homodimer interface [polypeptide binding]; other site 481743005269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743005270 catalytic residue [active] 481743005271 homoserine kinase; Provisional; Region: PRK01212 481743005272 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 481743005273 prephenate dehydratase; Provisional; Region: PRK11898 481743005274 Prephenate dehydratase; Region: PDT; pfam00800 481743005275 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 481743005276 putative L-Phe binding site [chemical binding]; other site 481743005277 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 481743005278 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 481743005279 homodimer interface [polypeptide binding]; other site 481743005280 substrate-cofactor binding pocket; other site 481743005281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743005282 catalytic residue [active] 481743005283 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 481743005284 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 481743005285 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 481743005286 BofC C-terminal domain; Region: BofC_C; pfam08955 481743005287 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 481743005288 active site 481743005289 putative DNA-binding cleft [nucleotide binding]; other site 481743005290 dimer interface [polypeptide binding]; other site 481743005291 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 481743005292 RuvA N terminal domain; Region: RuvA_N; pfam01330 481743005293 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 481743005294 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 481743005295 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 481743005296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743005297 Walker A motif; other site 481743005298 ATP binding site [chemical binding]; other site 481743005299 Walker B motif; other site 481743005300 arginine finger; other site 481743005301 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 481743005302 Stage II sporulation protein; Region: SpoIID; pfam08486 481743005303 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 481743005304 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 481743005305 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 481743005306 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 481743005307 Preprotein translocase subunit; Region: YajC; pfam02699 481743005308 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 481743005309 Predicted membrane protein [Function unknown]; Region: COG2323 481743005310 stage V sporulation protein B; Region: spore_V_B; TIGR02900 481743005311 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 481743005312 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 481743005313 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 481743005314 Cation efflux family; Region: Cation_efflux; pfam01545 481743005315 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 481743005316 DHH family; Region: DHH; pfam01368 481743005317 DHHA1 domain; Region: DHHA1; pfam02272 481743005318 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 481743005319 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 481743005320 active site 481743005321 uracil transporter; Provisional; Region: PRK10720 481743005322 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 481743005323 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 481743005324 Zn2+ binding site [ion binding]; other site 481743005325 Mg2+ binding site [ion binding]; other site 481743005326 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 481743005327 synthetase active site [active] 481743005328 NTP binding site [chemical binding]; other site 481743005329 metal binding site [ion binding]; metal-binding site 481743005330 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 481743005331 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 481743005332 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 481743005333 putative active site [active] 481743005334 dimerization interface [polypeptide binding]; other site 481743005335 putative tRNAtyr binding site [nucleotide binding]; other site 481743005336 intracellular protease, PfpI family; Region: PfpI; TIGR01382 481743005337 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 481743005338 proposed catalytic triad [active] 481743005339 conserved cys residue [active] 481743005340 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 481743005341 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 481743005342 dimer interface [polypeptide binding]; other site 481743005343 motif 1; other site 481743005344 active site 481743005345 motif 2; other site 481743005346 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 481743005347 anticodon binding site; other site 481743005348 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 481743005349 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 481743005350 dimer interface [polypeptide binding]; other site 481743005351 anticodon binding site; other site 481743005352 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 481743005353 homodimer interface [polypeptide binding]; other site 481743005354 motif 1; other site 481743005355 active site 481743005356 motif 2; other site 481743005357 GAD domain; Region: GAD; pfam02938 481743005358 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 481743005359 motif 3; other site 481743005360 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 481743005361 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 481743005362 putative ATP binding site [chemical binding]; other site 481743005363 putative substrate interface [chemical binding]; other site 481743005364 Part of AAA domain; Region: AAA_19; pfam13245 481743005365 Family description; Region: UvrD_C_2; pfam13538 481743005366 recombination factor protein RarA; Reviewed; Region: PRK13342 481743005367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743005368 Walker A motif; other site 481743005369 ATP binding site [chemical binding]; other site 481743005370 Walker B motif; other site 481743005371 arginine finger; other site 481743005372 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 481743005373 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 481743005374 ATP cone domain; Region: ATP-cone; pfam03477 481743005375 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 481743005376 Class III ribonucleotide reductase; Region: RNR_III; cd01675 481743005377 effector binding site; other site 481743005378 active site 481743005379 Zn binding site [ion binding]; other site 481743005380 glycine loop; other site 481743005381 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 481743005382 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 481743005383 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 481743005384 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 481743005385 Predicted transcriptional regulator [Transcription]; Region: COG1959 481743005386 Transcriptional regulator; Region: Rrf2; pfam02082 481743005387 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 481743005388 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 481743005389 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 481743005390 catalytic residue [active] 481743005391 PRC-barrel domain; Region: PRC; pfam05239 481743005392 PRC-barrel domain; Region: PRC; pfam05239 481743005393 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 481743005394 Domain of unknown function DUF20; Region: UPF0118; pfam01594 481743005395 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 481743005396 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 481743005397 motif 1; other site 481743005398 active site 481743005399 motif 2; other site 481743005400 motif 3; other site 481743005401 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 481743005402 DHHA1 domain; Region: DHHA1; pfam02272 481743005403 hypothetical protein; Provisional; Region: PRK05473 481743005404 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 481743005405 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 481743005406 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 481743005407 YceG-like family; Region: YceG; pfam02618 481743005408 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 481743005409 dimerization interface [polypeptide binding]; other site 481743005410 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 481743005411 Peptidase family U32; Region: Peptidase_U32; pfam01136 481743005412 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 481743005413 Peptidase family U32; Region: Peptidase_U32; pfam01136 481743005414 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 481743005415 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743005416 dimerization interface [polypeptide binding]; other site 481743005417 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 481743005418 dimer interface [polypeptide binding]; other site 481743005419 putative CheW interface [polypeptide binding]; other site 481743005420 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 481743005421 Spore germination protein; Region: Spore_permease; cl17796 481743005422 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 481743005423 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 481743005424 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 481743005425 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 481743005426 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 481743005427 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 481743005428 Domain of unknown function DUF20; Region: UPF0118; pfam01594 481743005429 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 481743005430 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 481743005431 NodB motif; other site 481743005432 putative active site [active] 481743005433 putative catalytic site [active] 481743005434 putative Zn binding site [ion binding]; other site 481743005435 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 481743005436 General stress protein [General function prediction only]; Region: GsiB; COG3729 481743005437 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 481743005438 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743005439 motif II; other site 481743005440 NAD-dependent deacetylase; Provisional; Region: PRK00481 481743005441 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 481743005442 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481743005443 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481743005444 active site 481743005445 catalytic tetrad [active] 481743005446 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743005447 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743005448 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743005449 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743005450 galactokinase; Provisional; Region: PRK05322 481743005451 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 481743005452 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 481743005453 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 481743005454 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 481743005455 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 481743005456 NAD binding site [chemical binding]; other site 481743005457 homodimer interface [polypeptide binding]; other site 481743005458 active site 481743005459 substrate binding site [chemical binding]; other site 481743005460 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 481743005461 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 481743005462 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 481743005463 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 481743005464 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 481743005465 dimer interface [polypeptide binding]; other site 481743005466 active site 481743005467 metal binding site [ion binding]; metal-binding site 481743005468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 481743005469 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 481743005470 transcriptional antiterminator BglG; Provisional; Region: PRK09772 481743005471 CAT RNA binding domain; Region: CAT_RBD; pfam03123 481743005472 PRD domain; Region: PRD; pfam00874 481743005473 PRD domain; Region: PRD; pfam00874 481743005474 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 481743005475 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 481743005476 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 481743005477 active site turn [active] 481743005478 phosphorylation site [posttranslational modification] 481743005479 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 481743005480 HPr interaction site; other site 481743005481 glycerol kinase (GK) interaction site [polypeptide binding]; other site 481743005482 active site 481743005483 phosphorylation site [posttranslational modification] 481743005484 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 481743005485 dimerization domain swap beta strand [polypeptide binding]; other site 481743005486 regulatory protein interface [polypeptide binding]; other site 481743005487 active site 481743005488 regulatory phosphorylation site [posttranslational modification]; other site 481743005489 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 481743005490 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 481743005491 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 481743005492 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 481743005493 pullulanase, type I; Region: pulA_typeI; TIGR02104 481743005494 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 481743005495 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 481743005496 Ca binding site [ion binding]; other site 481743005497 active site 481743005498 catalytic site [active] 481743005499 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 481743005500 carbohydrate binding site [chemical binding]; other site 481743005501 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 481743005502 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 481743005503 5S rRNA interface [nucleotide binding]; other site 481743005504 CTC domain interface [polypeptide binding]; other site 481743005505 L16 interface [polypeptide binding]; other site 481743005506 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 481743005507 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481743005508 substrate binding pocket [chemical binding]; other site 481743005509 membrane-bound complex binding site; other site 481743005510 hinge residues; other site 481743005511 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 481743005512 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 481743005513 NADP binding site [chemical binding]; other site 481743005514 homodimer interface [polypeptide binding]; other site 481743005515 active site 481743005516 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 481743005517 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743005518 putative DNA binding site [nucleotide binding]; other site 481743005519 putative Zn2+ binding site [ion binding]; other site 481743005520 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 481743005521 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 481743005522 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 481743005523 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 481743005524 active site 481743005525 catalytic site [active] 481743005526 metal binding site [ion binding]; metal-binding site 481743005527 dimer interface [polypeptide binding]; other site 481743005528 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 481743005529 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 481743005530 putative ligand binding site [chemical binding]; other site 481743005531 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 481743005532 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481743005533 TM-ABC transporter signature motif; other site 481743005534 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 481743005535 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 481743005536 TM-ABC transporter signature motif; other site 481743005537 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 481743005538 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 481743005539 Walker A/P-loop; other site 481743005540 ATP binding site [chemical binding]; other site 481743005541 Q-loop/lid; other site 481743005542 ABC transporter signature motif; other site 481743005543 Walker B; other site 481743005544 D-loop; other site 481743005545 H-loop/switch region; other site 481743005546 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 481743005547 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 481743005548 Walker A/P-loop; other site 481743005549 ATP binding site [chemical binding]; other site 481743005550 Q-loop/lid; other site 481743005551 ABC transporter signature motif; other site 481743005552 Walker B; other site 481743005553 D-loop; other site 481743005554 H-loop/switch region; other site 481743005555 L-arabinose isomerase; Provisional; Region: PRK02929 481743005556 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 481743005557 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 481743005558 trimer interface [polypeptide binding]; other site 481743005559 putative substrate binding site [chemical binding]; other site 481743005560 putative metal binding site [ion binding]; other site 481743005561 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 481743005562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743005563 DNA-binding site [nucleotide binding]; DNA binding site 481743005564 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 481743005565 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 481743005566 putative dimerization interface [polypeptide binding]; other site 481743005567 putative ligand binding site [chemical binding]; other site 481743005568 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 481743005569 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 481743005570 intersubunit interface [polypeptide binding]; other site 481743005571 active site 481743005572 Zn2+ binding site [ion binding]; other site 481743005573 ribulokinase; Provisional; Region: PRK04123 481743005574 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 481743005575 N- and C-terminal domain interface [polypeptide binding]; other site 481743005576 active site 481743005577 MgATP binding site [chemical binding]; other site 481743005578 catalytic site [active] 481743005579 metal binding site [ion binding]; metal-binding site 481743005580 carbohydrate binding site [chemical binding]; other site 481743005581 homodimer interface [polypeptide binding]; other site 481743005582 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 481743005583 active site 481743005584 metal binding site [ion binding]; metal-binding site 481743005585 Predicted transcriptional regulator [Transcription]; Region: COG4189 481743005586 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743005587 dimerization interface [polypeptide binding]; other site 481743005588 putative DNA binding site [nucleotide binding]; other site 481743005589 putative Zn2+ binding site [ion binding]; other site 481743005590 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 481743005591 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 481743005592 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743005593 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743005594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743005595 dimer interface [polypeptide binding]; other site 481743005596 conserved gate region; other site 481743005597 putative PBP binding loops; other site 481743005598 ABC-ATPase subunit interface; other site 481743005599 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743005600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743005601 dimer interface [polypeptide binding]; other site 481743005602 conserved gate region; other site 481743005603 putative PBP binding loops; other site 481743005604 ABC-ATPase subunit interface; other site 481743005605 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 481743005606 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 481743005607 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 481743005608 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 481743005609 TrkA-C domain; Region: TrkA_C; pfam02080 481743005610 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743005611 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743005612 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 481743005613 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743005614 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743005615 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743005616 dimerization interface [polypeptide binding]; other site 481743005617 Histidine kinase; Region: His_kinase; pfam06580 481743005618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743005619 ATP binding site [chemical binding]; other site 481743005620 Mg2+ binding site [ion binding]; other site 481743005621 G-X-G motif; other site 481743005622 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 481743005623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743005624 active site 481743005625 phosphorylation site [posttranslational modification] 481743005626 intermolecular recognition site; other site 481743005627 dimerization interface [polypeptide binding]; other site 481743005628 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743005629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743005630 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743005631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743005632 dimer interface [polypeptide binding]; other site 481743005633 conserved gate region; other site 481743005634 putative PBP binding loops; other site 481743005635 ABC-ATPase subunit interface; other site 481743005636 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743005637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 481743005638 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743005639 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743005640 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 481743005641 S-layer homology domain; Region: SLH; pfam00395 481743005642 S-layer homology domain; Region: SLH; pfam00395 481743005643 S-layer homology domain; Region: SLH; pfam00395 481743005644 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 481743005645 aminoglycoside resistance protein; Provisional; Region: PRK13746 481743005646 active site 481743005647 NTP binding site [chemical binding]; other site 481743005648 metal binding triad [ion binding]; metal-binding site 481743005649 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 481743005650 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 481743005651 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 481743005652 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 481743005653 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743005654 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743005655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743005656 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743005657 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743005658 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743005659 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 481743005660 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743005661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743005662 dimer interface [polypeptide binding]; other site 481743005663 conserved gate region; other site 481743005664 ABC-ATPase subunit interface; other site 481743005665 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743005666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743005667 dimer interface [polypeptide binding]; other site 481743005668 conserved gate region; other site 481743005669 putative PBP binding loops; other site 481743005670 ABC-ATPase subunit interface; other site 481743005671 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_3; cd09002 481743005672 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 481743005673 active site 481743005674 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 481743005675 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 481743005676 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 481743005677 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 481743005678 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 481743005679 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743005680 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 481743005681 Walker A/P-loop; other site 481743005682 ATP binding site [chemical binding]; other site 481743005683 Q-loop/lid; other site 481743005684 ABC transporter signature motif; other site 481743005685 Walker B; other site 481743005686 D-loop; other site 481743005687 H-loop/switch region; other site 481743005688 Predicted membrane protein [Function unknown]; Region: COG1470 481743005689 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 481743005690 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 481743005691 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 481743005692 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743005693 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743005694 DNA binding residues [nucleotide binding] 481743005695 Anti-sigma-K factor rskA; Region: RskA; pfam10099 481743005696 Abhydrolase family; Region: Abhydrolase_7; pfam12715 481743005697 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 481743005698 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663 481743005699 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 481743005700 metal binding site [ion binding]; metal-binding site 481743005701 ligand binding site [chemical binding]; other site 481743005702 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 481743005703 ligand binding site [chemical binding]; other site 481743005704 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 481743005705 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743005706 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743005707 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743005708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743005709 dimer interface [polypeptide binding]; other site 481743005710 conserved gate region; other site 481743005711 putative PBP binding loops; other site 481743005712 ABC-ATPase subunit interface; other site 481743005713 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743005714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743005715 dimer interface [polypeptide binding]; other site 481743005716 conserved gate region; other site 481743005717 putative PBP binding loops; other site 481743005718 ABC-ATPase subunit interface; other site 481743005719 Uncharacterized conserved protein [Function unknown]; Region: COG3538 481743005720 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 481743005721 sporulation sigma factor SigK; Reviewed; Region: PRK05803 481743005722 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743005723 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743005724 DNA binding residues [nucleotide binding] 481743005725 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 481743005726 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 481743005727 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 481743005728 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 481743005729 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 481743005730 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 481743005731 Walker A/P-loop; other site 481743005732 ATP binding site [chemical binding]; other site 481743005733 Q-loop/lid; other site 481743005734 ABC transporter signature motif; other site 481743005735 Walker B; other site 481743005736 D-loop; other site 481743005737 H-loop/switch region; other site 481743005738 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 481743005739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743005740 dimer interface [polypeptide binding]; other site 481743005741 conserved gate region; other site 481743005742 putative PBP binding loops; other site 481743005743 ABC-ATPase subunit interface; other site 481743005744 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 481743005745 NMT1-like family; Region: NMT1_2; pfam13379 481743005746 Isochorismatase family; Region: Isochorismatase; pfam00857 481743005747 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 481743005748 catalytic triad [active] 481743005749 conserved cis-peptide bond; other site 481743005750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743005751 putative substrate translocation pore; other site 481743005752 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 481743005753 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 481743005754 oligomer interface [polypeptide binding]; other site 481743005755 active site 481743005756 metal binding site [ion binding]; metal-binding site 481743005757 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 481743005758 stage V sporulation protein AD; Provisional; Region: PRK12404 481743005759 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 481743005760 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 481743005761 MoxR-like ATPases [General function prediction only]; Region: COG0714 481743005762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743005763 Walker A motif; other site 481743005764 ATP binding site [chemical binding]; other site 481743005765 Walker B motif; other site 481743005766 arginine finger; other site 481743005767 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 481743005768 Protein of unknown function DUF58; Region: DUF58; pfam01882 481743005769 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 481743005770 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 481743005771 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 481743005772 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 481743005773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743005774 active site 481743005775 motif I; other site 481743005776 motif II; other site 481743005777 GTPase YqeH; Provisional; Region: PRK13796 481743005778 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 481743005779 GTP/Mg2+ binding site [chemical binding]; other site 481743005780 G4 box; other site 481743005781 G5 box; other site 481743005782 G1 box; other site 481743005783 Switch I region; other site 481743005784 G2 box; other site 481743005785 G3 box; other site 481743005786 Switch II region; other site 481743005787 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 481743005788 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 481743005789 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 481743005790 shikimate binding site; other site 481743005791 NAD(P) binding site [chemical binding]; other site 481743005792 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 481743005793 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 481743005794 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 481743005795 active site 481743005796 (T/H)XGH motif; other site 481743005797 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 481743005798 Zn2+ binding site [ion binding]; other site 481743005799 Mg2+ binding site [ion binding]; other site 481743005800 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 481743005801 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 481743005802 S1 domain; Region: S1_2; pfam13509 481743005803 S1 domain; Region: S1_2; pfam13509 481743005804 MarR family; Region: MarR_2; pfam12802 481743005805 Methyltransferase domain; Region: Methyltransf_31; pfam13847 481743005806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743005807 S-adenosylmethionine binding site [chemical binding]; other site 481743005808 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 481743005809 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 481743005810 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 481743005811 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743005812 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743005813 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743005814 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743005815 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743005816 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743005817 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743005818 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743005819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743005820 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 481743005821 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 481743005822 HIGH motif; other site 481743005823 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 481743005824 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 481743005825 active site 481743005826 KMSKS motif; other site 481743005827 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 481743005828 tRNA binding surface [nucleotide binding]; other site 481743005829 late competence protein ComER; Validated; Region: PRK07680 481743005830 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 481743005831 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 481743005832 Helix-hairpin-helix motif; Region: HHH; pfam00633 481743005833 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 481743005834 catalytic motif [active] 481743005835 Zn binding site [ion binding]; other site 481743005836 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 481743005837 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 481743005838 Competence protein; Region: Competence; pfam03772 481743005839 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 481743005840 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 481743005841 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 481743005842 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743005843 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743005844 DNA binding residues [nucleotide binding] 481743005845 Putative zinc-finger; Region: zf-HC2; pfam13490 481743005846 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 481743005847 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 481743005848 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 481743005849 germination protease; Provisional; Region: PRK02858 481743005850 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 481743005851 stage II sporulation protein P; Region: spore_II_P; TIGR02867 481743005852 GTP-binding protein LepA; Provisional; Region: PRK05433 481743005853 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 481743005854 G1 box; other site 481743005855 putative GEF interaction site [polypeptide binding]; other site 481743005856 GTP/Mg2+ binding site [chemical binding]; other site 481743005857 Switch I region; other site 481743005858 G2 box; other site 481743005859 G3 box; other site 481743005860 Switch II region; other site 481743005861 G4 box; other site 481743005862 G5 box; other site 481743005863 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 481743005864 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 481743005865 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 481743005866 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 481743005867 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743005868 FeS/SAM binding site; other site 481743005869 HemN C-terminal domain; Region: HemN_C; pfam06969 481743005870 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743005871 Coenzyme A binding pocket [chemical binding]; other site 481743005872 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 481743005873 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 481743005874 chaperonin families, type I and type II. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The...; Region: chaperonin_type_I_II; cd00309 481743005875 thermosome, various subunits, archaeal; Region: thermosome_arch; TIGR02339 481743005876 ATP/Mg binding site [chemical binding]; other site 481743005877 ring oligomerisation interface [polypeptide binding]; other site 481743005878 hinge regions; other site 481743005879 stacking interactions; other site 481743005880 GrpE; Region: GrpE; pfam01025 481743005881 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 481743005882 dimer interface [polypeptide binding]; other site 481743005883 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 481743005884 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 481743005885 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 481743005886 nucleotide binding site [chemical binding]; other site 481743005887 NEF interaction site [polypeptide binding]; other site 481743005888 SBD interface [polypeptide binding]; other site 481743005889 chaperone protein DnaJ; Provisional; Region: PRK14280 481743005890 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 481743005891 HSP70 interaction site [polypeptide binding]; other site 481743005892 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 481743005893 substrate binding site [polypeptide binding]; other site 481743005894 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 481743005895 Zn binding sites [ion binding]; other site 481743005896 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 481743005897 dimer interface [polypeptide binding]; other site 481743005898 YfhD-like protein; Region: YfhD; pfam14151 481743005899 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 481743005900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743005901 S-adenosylmethionine binding site [chemical binding]; other site 481743005902 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 481743005903 Peptidase family M50; Region: Peptidase_M50; pfam02163 481743005904 active site 481743005905 putative substrate binding region [chemical binding]; other site 481743005906 RNA methyltransferase, RsmE family; Region: TIGR00046 481743005907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 481743005908 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 481743005909 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 481743005910 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743005911 FeS/SAM binding site; other site 481743005912 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 481743005913 active site 481743005914 Ap6A binding site [chemical binding]; other site 481743005915 nudix motif; other site 481743005916 metal binding site [ion binding]; metal-binding site 481743005917 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 481743005918 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 481743005919 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 481743005920 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 481743005921 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 481743005922 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 481743005923 putative RNA binding site [nucleotide binding]; other site 481743005924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743005925 S-adenosylmethionine binding site [chemical binding]; other site 481743005926 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 481743005927 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 481743005928 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 481743005929 DEAD/DEAH box helicase; Region: DEAD; pfam00270 481743005930 Family description; Region: UvrD_C_2; pfam13538 481743005931 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 481743005932 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 481743005933 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 481743005934 active site 481743005935 metal binding site [ion binding]; metal-binding site 481743005936 DNA binding site [nucleotide binding] 481743005937 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 481743005938 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 481743005939 AAA domain; Region: AAA_23; pfam13476 481743005940 Walker A/P-loop; other site 481743005941 ATP binding site [chemical binding]; other site 481743005942 Q-loop/lid; other site 481743005943 ABC transporter signature motif; other site 481743005944 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 481743005945 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743005946 ABC transporter signature motif; other site 481743005947 Walker B; other site 481743005948 D-loop; other site 481743005949 H-loop/switch region; other site 481743005950 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 481743005951 nucleotide binding site/active site [active] 481743005952 HIT family signature motif; other site 481743005953 catalytic residue [active] 481743005954 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 481743005955 Yqey-like protein; Region: YqeY; pfam09424 481743005956 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 481743005957 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 481743005958 dimer interface [polypeptide binding]; other site 481743005959 active site residues [active] 481743005960 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 481743005961 hypothetical protein; Provisional; Region: PRK13665 481743005962 putative methyltransferase; Provisional; Region: PRK10864 481743005963 YabP family; Region: YabP; cl06766 481743005964 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 481743005965 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 481743005966 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 481743005967 PhoH-like protein; Region: PhoH; pfam02562 481743005968 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 481743005969 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 481743005970 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 481743005971 Zn2+ binding site [ion binding]; other site 481743005972 Mg2+ binding site [ion binding]; other site 481743005973 metal-binding heat shock protein; Provisional; Region: PRK00016 481743005974 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 481743005975 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 481743005976 active site 481743005977 catalytic motif [active] 481743005978 Zn binding site [ion binding]; other site 481743005979 GTPase Era; Reviewed; Region: era; PRK00089 481743005980 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 481743005981 G1 box; other site 481743005982 GTP/Mg2+ binding site [chemical binding]; other site 481743005983 Switch I region; other site 481743005984 G2 box; other site 481743005985 Switch II region; other site 481743005986 G3 box; other site 481743005987 G4 box; other site 481743005988 G5 box; other site 481743005989 KH domain; Region: KH_2; pfam07650 481743005990 YqzL-like protein; Region: YqzL; pfam14006 481743005991 Recombination protein O N terminal; Region: RecO_N; pfam11967 481743005992 DNA repair protein RecO; Region: reco; TIGR00613 481743005993 Recombination protein O C terminal; Region: RecO_C; pfam02565 481743005994 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 481743005995 dimer interface [polypeptide binding]; other site 481743005996 motif 1; other site 481743005997 active site 481743005998 motif 2; other site 481743005999 motif 3; other site 481743006000 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 481743006001 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 481743006002 DNA primase; Validated; Region: dnaG; PRK05667 481743006003 CHC2 zinc finger; Region: zf-CHC2; pfam01807 481743006004 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 481743006005 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 481743006006 active site 481743006007 metal binding site [ion binding]; metal-binding site 481743006008 interdomain interaction site; other site 481743006009 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 481743006010 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 481743006011 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 481743006012 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 481743006013 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743006014 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 481743006015 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743006016 DNA binding residues [nucleotide binding] 481743006017 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 481743006018 Family of unknown function (DUF633); Region: DUF633; pfam04816 481743006019 Uncharacterized conserved protein [Function unknown]; Region: COG0327 481743006020 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 481743006021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 481743006022 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 481743006023 Uncharacterized conserved protein [Function unknown]; Region: COG0327 481743006024 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 481743006025 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 481743006026 active site 481743006027 catalytic triad [active] 481743006028 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 481743006029 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 481743006030 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 481743006031 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 481743006032 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 481743006033 N-acetyl-D-glucosamine binding site [chemical binding]; other site 481743006034 catalytic residue [active] 481743006035 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 481743006036 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 481743006037 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 481743006038 catalytic residue [active] 481743006039 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 481743006040 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 481743006041 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 481743006042 Ligand Binding Site [chemical binding]; other site 481743006043 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 481743006044 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 481743006045 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 481743006046 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 481743006047 G1 box; other site 481743006048 putative GEF interaction site [polypeptide binding]; other site 481743006049 GTP/Mg2+ binding site [chemical binding]; other site 481743006050 Switch I region; other site 481743006051 G2 box; other site 481743006052 G3 box; other site 481743006053 Switch II region; other site 481743006054 G4 box; other site 481743006055 G5 box; other site 481743006056 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 481743006057 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 481743006058 YlaH-like protein; Region: YlaH; pfam14036 481743006059 Transcriptional regulator [Transcription]; Region: LytR; COG1316 481743006060 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 481743006061 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 481743006062 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 481743006063 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 481743006064 putative active site [active] 481743006065 PhoH-like protein; Region: PhoH; pfam02562 481743006066 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 481743006067 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 481743006068 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 481743006069 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 481743006070 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 481743006071 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 481743006072 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 481743006073 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 481743006074 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 481743006075 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 481743006076 peptide binding site [polypeptide binding]; other site 481743006077 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 481743006078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743006079 dimer interface [polypeptide binding]; other site 481743006080 conserved gate region; other site 481743006081 ABC-ATPase subunit interface; other site 481743006082 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 481743006083 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 481743006084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743006085 dimer interface [polypeptide binding]; other site 481743006086 conserved gate region; other site 481743006087 putative PBP binding loops; other site 481743006088 ABC-ATPase subunit interface; other site 481743006089 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 481743006090 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743006091 Walker A/P-loop; other site 481743006092 ATP binding site [chemical binding]; other site 481743006093 Q-loop/lid; other site 481743006094 ABC transporter signature motif; other site 481743006095 Walker B; other site 481743006096 D-loop; other site 481743006097 H-loop/switch region; other site 481743006098 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 481743006099 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 481743006100 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743006101 Walker A/P-loop; other site 481743006102 ATP binding site [chemical binding]; other site 481743006103 Q-loop/lid; other site 481743006104 ABC transporter signature motif; other site 481743006105 Walker B; other site 481743006106 D-loop; other site 481743006107 H-loop/switch region; other site 481743006108 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 481743006109 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 481743006110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 481743006111 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 481743006112 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 481743006113 homotetramer interface [polypeptide binding]; other site 481743006114 ligand binding site [chemical binding]; other site 481743006115 catalytic site [active] 481743006116 NAD binding site [chemical binding]; other site 481743006117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 481743006118 MraZ protein; Region: MraZ; pfam02381 481743006119 MraZ protein; Region: MraZ; pfam02381 481743006120 MraW methylase family; Region: Methyltransf_5; pfam01795 481743006121 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 481743006122 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 481743006123 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 481743006124 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 481743006125 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 481743006126 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 481743006127 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 481743006128 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 481743006129 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 481743006130 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 481743006131 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 481743006132 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 481743006133 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 481743006134 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 481743006135 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 481743006136 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 481743006137 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 481743006138 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 481743006139 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 481743006140 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 481743006141 Mg++ binding site [ion binding]; other site 481743006142 putative catalytic motif [active] 481743006143 putative substrate binding site [chemical binding]; other site 481743006144 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 481743006145 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 481743006146 NAD(P) binding pocket [chemical binding]; other site 481743006147 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 481743006148 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 481743006149 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 481743006150 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 481743006151 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 481743006152 active site 481743006153 homodimer interface [polypeptide binding]; other site 481743006154 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 481743006155 FAD binding domain; Region: FAD_binding_4; pfam01565 481743006156 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 481743006157 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 481743006158 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 481743006159 hinge; other site 481743006160 active site 481743006161 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 481743006162 Cell division protein FtsQ; Region: FtsQ; pfam03799 481743006163 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 481743006164 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 481743006165 nucleotide binding site [chemical binding]; other site 481743006166 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 481743006167 Cell division protein FtsA; Region: FtsA; pfam14450 481743006168 cell division protein FtsZ; Validated; Region: PRK09330 481743006169 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 481743006170 nucleotide binding site [chemical binding]; other site 481743006171 SulA interaction site; other site 481743006172 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 481743006173 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 481743006174 sporulation sigma factor SigE; Reviewed; Region: PRK08301 481743006175 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743006176 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743006177 DNA binding residues [nucleotide binding] 481743006178 sporulation sigma factor SigG; Reviewed; Region: PRK08215 481743006179 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743006180 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 481743006181 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743006182 DNA binding residues [nucleotide binding] 481743006183 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 481743006184 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 481743006185 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 481743006186 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 481743006187 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 481743006188 catalytic residue [active] 481743006189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 481743006190 YGGT family; Region: YGGT; pfam02325 481743006191 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 481743006192 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 481743006193 RNA binding surface [nucleotide binding]; other site 481743006194 DivIVA protein; Region: DivIVA; pfam05103 481743006195 DivIVA domain; Region: DivI1A_domain; TIGR03544 481743006196 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 481743006197 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 481743006198 HIGH motif; other site 481743006199 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 481743006200 active site 481743006201 KMSKS motif; other site 481743006202 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 481743006203 tRNA binding surface [nucleotide binding]; other site 481743006204 anticodon binding site; other site 481743006205 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 481743006206 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 481743006207 lipoprotein signal peptidase; Provisional; Region: PRK14787 481743006208 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 481743006209 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 481743006210 RNA binding surface [nucleotide binding]; other site 481743006211 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 481743006212 active site 481743006213 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 481743006214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743006215 Walker A/P-loop; other site 481743006216 ATP binding site [chemical binding]; other site 481743006217 Q-loop/lid; other site 481743006218 ABC transporter signature motif; other site 481743006219 Walker B; other site 481743006220 D-loop; other site 481743006221 H-loop/switch region; other site 481743006222 ABC transporter; Region: ABC_tran_2; pfam12848 481743006223 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481743006224 aspartate aminotransferase; Provisional; Region: PRK06290 481743006225 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743006226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743006227 homodimer interface [polypeptide binding]; other site 481743006228 catalytic residue [active] 481743006229 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 481743006230 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 481743006231 active site 481743006232 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 481743006233 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 481743006234 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 481743006235 dihydroorotase; Validated; Region: pyrC; PRK09357 481743006236 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 481743006237 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 481743006238 active site 481743006239 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 481743006240 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 481743006241 Ubiquitin-like proteins; Region: UBQ; cl00155 481743006242 hydrophobic patch; other site 481743006243 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 481743006244 catalytic site [active] 481743006245 subunit interface [polypeptide binding]; other site 481743006246 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 481743006247 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 481743006248 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 481743006249 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 481743006250 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 481743006251 ATP-grasp domain; Region: ATP-grasp_4; cl17255 481743006252 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 481743006253 IMP binding site; other site 481743006254 dimer interface [polypeptide binding]; other site 481743006255 interdomain contacts; other site 481743006256 partial ornithine binding site; other site 481743006257 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 481743006258 active site 481743006259 dimer interface [polypeptide binding]; other site 481743006260 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 481743006261 active site 481743006262 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743006263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743006264 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 481743006265 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 481743006266 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 481743006267 Predicted membrane protein [Function unknown]; Region: COG2323 481743006268 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 481743006269 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 481743006270 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743006271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743006272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743006273 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743006274 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743006275 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 481743006276 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 481743006277 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 481743006278 NodB motif; other site 481743006279 active site 481743006280 catalytic site [active] 481743006281 metal binding site [ion binding]; metal-binding site 481743006282 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 481743006283 ligand binding site [chemical binding]; other site 481743006284 active site 481743006285 UGI interface [polypeptide binding]; other site 481743006286 catalytic site [active] 481743006287 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 481743006288 Domain of unknown function DUF20; Region: UPF0118; pfam01594 481743006289 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 481743006290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 481743006291 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743006292 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743006293 dimerization interface [polypeptide binding]; other site 481743006294 Histidine kinase; Region: His_kinase; pfam06580 481743006295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743006296 ATP binding site [chemical binding]; other site 481743006297 Mg2+ binding site [ion binding]; other site 481743006298 G-X-G motif; other site 481743006299 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 481743006300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743006301 active site 481743006302 phosphorylation site [posttranslational modification] 481743006303 intermolecular recognition site; other site 481743006304 dimerization interface [polypeptide binding]; other site 481743006305 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743006306 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743006307 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 481743006308 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 481743006309 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743006310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743006311 dimer interface [polypeptide binding]; other site 481743006312 conserved gate region; other site 481743006313 ABC-ATPase subunit interface; other site 481743006314 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743006315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743006316 dimer interface [polypeptide binding]; other site 481743006317 conserved gate region; other site 481743006318 ABC-ATPase subunit interface; other site 481743006319 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 481743006320 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 481743006321 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 481743006322 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 481743006323 active site 481743006324 catalytic site [active] 481743006325 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 481743006326 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 481743006327 Uncharacterized conserved protein [Function unknown]; Region: COG3538 481743006328 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 481743006329 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 481743006330 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 481743006331 conserved cys residue [active] 481743006332 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 481743006333 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 481743006334 active site 481743006335 metal binding site [ion binding]; metal-binding site 481743006336 homodimer interface [polypeptide binding]; other site 481743006337 catalytic site [active] 481743006338 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 481743006339 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 481743006340 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 481743006341 putative active site [active] 481743006342 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743006343 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 481743006344 dimer interface [polypeptide binding]; other site 481743006345 putative metal binding site [ion binding]; other site 481743006346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 481743006347 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 481743006348 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743006349 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743006350 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 481743006351 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743006352 Coenzyme A binding pocket [chemical binding]; other site 481743006353 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 481743006354 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 481743006355 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481743006356 Walker A/P-loop; other site 481743006357 ATP binding site [chemical binding]; other site 481743006358 Q-loop/lid; other site 481743006359 ABC transporter signature motif; other site 481743006360 Walker B; other site 481743006361 D-loop; other site 481743006362 H-loop/switch region; other site 481743006363 Accessory gene regulator B; Region: AgrB; cl01873 481743006364 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 481743006365 Predicted transcriptional regulator [Transcription]; Region: COG2378 481743006366 YolD-like protein; Region: YolD; pfam08863 481743006367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743006368 Coenzyme A binding pocket [chemical binding]; other site 481743006369 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 481743006370 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 481743006371 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743006372 Filamin/ABP280 repeat; Region: Filamin; pfam00630 481743006373 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 481743006374 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 481743006375 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 481743006376 homodimer interface [polypeptide binding]; other site 481743006377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743006378 catalytic residue [active] 481743006379 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 481743006380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 481743006381 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 481743006382 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 481743006383 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 481743006384 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 481743006385 shikimate kinase; Reviewed; Region: aroK; PRK00131 481743006386 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 481743006387 ADP binding site [chemical binding]; other site 481743006388 magnesium binding site [ion binding]; other site 481743006389 putative shikimate binding site; other site 481743006390 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 481743006391 active site residue [active] 481743006392 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 481743006393 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 481743006394 hinge; other site 481743006395 active site 481743006396 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 481743006397 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 481743006398 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 481743006399 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 481743006400 active site turn [active] 481743006401 phosphorylation site [posttranslational modification] 481743006402 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 481743006403 HPr interaction site; other site 481743006404 glycerol kinase (GK) interaction site [polypeptide binding]; other site 481743006405 active site 481743006406 phosphorylation site [posttranslational modification] 481743006407 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 481743006408 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 481743006409 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 481743006410 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 481743006411 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 481743006412 intracellular protease, PfpI family; Region: PfpI; TIGR01382 481743006413 proposed catalytic triad [active] 481743006414 conserved cys residue [active] 481743006415 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 481743006416 catabolite control protein A; Region: ccpA; TIGR01481 481743006417 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743006418 DNA binding site [nucleotide binding] 481743006419 domain linker motif; other site 481743006420 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 481743006421 dimerization interface [polypeptide binding]; other site 481743006422 effector binding site; other site 481743006423 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 481743006424 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 481743006425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743006426 Coenzyme A binding pocket [chemical binding]; other site 481743006427 acetyl-CoA synthetase; Provisional; Region: PRK04319 481743006428 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 481743006429 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 481743006430 active site 481743006431 acyl-activating enzyme (AAE) consensus motif; other site 481743006432 putative CoA binding site [chemical binding]; other site 481743006433 AMP binding site [chemical binding]; other site 481743006434 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 481743006435 Transglycosylase; Region: Transgly; pfam00912 481743006436 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 481743006437 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 481743006438 Interdomain contacts; other site 481743006439 Cytokine receptor motif; other site 481743006440 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 481743006441 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 481743006442 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 481743006443 RNA binding surface [nucleotide binding]; other site 481743006444 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 481743006445 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 481743006446 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481743006447 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481743006448 metal binding site [ion binding]; metal-binding site 481743006449 active site 481743006450 I-site; other site 481743006451 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 481743006452 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 481743006453 PTS HPr component phosphorylation site; Region: PTS-HPr; pfam00381 481743006454 regulatory protein interface [polypeptide binding]; other site 481743006455 regulatory phosphorylation site [posttranslational modification]; other site 481743006456 hypothetical protein; Provisional; Region: PRK13666 481743006457 calcium/proton exchanger (cax); Region: cax; TIGR00378 481743006458 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 481743006459 Asp23 family; Region: Asp23; pfam03780 481743006460 cell division protein FtsW; Region: ftsW; TIGR02614 481743006461 YugN-like family; Region: YugN; pfam08868 481743006462 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 481743006463 dimer interface [polypeptide binding]; other site 481743006464 ADP-ribose binding site [chemical binding]; other site 481743006465 active site 481743006466 nudix motif; other site 481743006467 metal binding site [ion binding]; metal-binding site 481743006468 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 481743006469 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 481743006470 metal binding site [ion binding]; metal-binding site 481743006471 dimer interface [polypeptide binding]; other site 481743006472 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 481743006473 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 481743006474 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481743006475 ATP binding site [chemical binding]; other site 481743006476 putative Mg++ binding site [ion binding]; other site 481743006477 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481743006478 nucleotide binding region [chemical binding]; other site 481743006479 ATP-binding site [chemical binding]; other site 481743006480 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 481743006481 Protein of unknown function (DUF964); Region: DUF964; pfam06133 481743006482 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 481743006483 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743006484 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743006485 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 481743006486 putative dimerization interface [polypeptide binding]; other site 481743006487 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 481743006488 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 481743006489 active site 481743006490 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 481743006491 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 481743006492 Domain of unknown function (DUF814); Region: DUF814; pfam05670 481743006493 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 481743006494 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 481743006495 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 481743006496 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 481743006497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743006498 motif II; other site 481743006499 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 481743006500 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 481743006501 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 481743006502 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 481743006503 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 481743006504 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 481743006505 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 481743006506 FAD binding site [chemical binding]; other site 481743006507 hypothetical protein; Provisional; Region: PRK11820 481743006508 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 481743006509 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 481743006510 hypothetical protein; Provisional; Region: PRK04323 481743006511 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 481743006512 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 481743006513 catalytic site [active] 481743006514 G-X2-G-X-G-K; other site 481743006515 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 481743006516 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 481743006517 Flavoprotein; Region: Flavoprotein; pfam02441 481743006518 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 481743006519 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481743006520 primosomal protein N' Region: priA; TIGR00595 481743006521 ATP binding site [chemical binding]; other site 481743006522 putative Mg++ binding site [ion binding]; other site 481743006523 nucleotide binding region [chemical binding]; other site 481743006524 helicase superfamily c-terminal domain; Region: HELICc; smart00490 481743006525 ATP-binding site [chemical binding]; other site 481743006526 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 481743006527 active site 481743006528 catalytic residues [active] 481743006529 metal binding site [ion binding]; metal-binding site 481743006530 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 481743006531 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 481743006532 putative active site [active] 481743006533 substrate binding site [chemical binding]; other site 481743006534 putative cosubstrate binding site; other site 481743006535 catalytic site [active] 481743006536 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 481743006537 substrate binding site [chemical binding]; other site 481743006538 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 481743006539 16S rRNA methyltransferase B; Provisional; Region: PRK14902 481743006540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743006541 S-adenosylmethionine binding site [chemical binding]; other site 481743006542 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 481743006543 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743006544 FeS/SAM binding site; other site 481743006545 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 481743006546 active site 481743006547 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 481743006548 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 481743006549 active site 481743006550 ATP binding site [chemical binding]; other site 481743006551 substrate binding site [chemical binding]; other site 481743006552 activation loop (A-loop); other site 481743006553 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 481743006554 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 481743006555 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 481743006556 GTPase RsgA; Reviewed; Region: PRK00098 481743006557 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 481743006558 RNA binding site [nucleotide binding]; other site 481743006559 homodimer interface [polypeptide binding]; other site 481743006560 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 481743006561 GTPase/Zn-binding domain interface [polypeptide binding]; other site 481743006562 GTP/Mg2+ binding site [chemical binding]; other site 481743006563 G4 box; other site 481743006564 G5 box; other site 481743006565 G1 box; other site 481743006566 Switch I region; other site 481743006567 G2 box; other site 481743006568 G3 box; other site 481743006569 Switch II region; other site 481743006570 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 481743006571 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 481743006572 substrate binding site [chemical binding]; other site 481743006573 hexamer interface [polypeptide binding]; other site 481743006574 metal binding site [ion binding]; metal-binding site 481743006575 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 481743006576 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 481743006577 DAK2 domain; Region: Dak2; pfam02734 481743006578 EDD domain protein, DegV family; Region: DegV; TIGR00762 481743006579 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 481743006580 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 481743006581 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 481743006582 generic binding surface II; other site 481743006583 ssDNA binding site; other site 481743006584 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481743006585 ATP binding site [chemical binding]; other site 481743006586 putative Mg++ binding site [ion binding]; other site 481743006587 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481743006588 nucleotide binding region [chemical binding]; other site 481743006589 ATP-binding site [chemical binding]; other site 481743006590 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 481743006591 Uncharacterized conserved protein [Function unknown]; Region: COG2135 481743006592 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 481743006593 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 481743006594 YolD-like protein; Region: YolD; pfam08863 481743006595 DNA polymerase IV; Reviewed; Region: PRK03103 481743006596 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 481743006597 active site 481743006598 DNA binding site [nucleotide binding] 481743006599 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 481743006600 Cache domain; Region: Cache_1; pfam02743 481743006601 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481743006602 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481743006603 metal binding site [ion binding]; metal-binding site 481743006604 active site 481743006605 I-site; other site 481743006606 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743006607 dimerization interface [polypeptide binding]; other site 481743006608 putative DNA binding site [nucleotide binding]; other site 481743006609 putative Zn2+ binding site [ion binding]; other site 481743006610 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 481743006611 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743006612 dimerization interface [polypeptide binding]; other site 481743006613 putative DNA binding site [nucleotide binding]; other site 481743006614 putative Zn2+ binding site [ion binding]; other site 481743006615 arsenical pump membrane protein; Provisional; Region: PRK15445 481743006616 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 481743006617 transmembrane helices; other site 481743006618 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 481743006619 Low molecular weight phosphatase family; Region: LMWPc; cd00115 481743006620 active site 481743006621 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 481743006622 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743006623 DNA-binding site [nucleotide binding]; DNA binding site 481743006624 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743006625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743006626 homodimer interface [polypeptide binding]; other site 481743006627 catalytic residue [active] 481743006628 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 481743006629 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 481743006630 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 481743006631 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743006632 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743006633 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743006634 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 481743006635 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 481743006636 [4Fe-4S] binding site [ion binding]; other site 481743006637 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 481743006638 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 481743006639 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 481743006640 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 481743006641 molybdopterin cofactor binding site; other site 481743006642 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 481743006643 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 481743006644 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 481743006645 GAF domain; Region: GAF; pfam01590 481743006646 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 481743006647 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 481743006648 Histidine kinase; Region: HisKA_3; pfam07730 481743006649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743006650 ATP binding site [chemical binding]; other site 481743006651 Mg2+ binding site [ion binding]; other site 481743006652 G-X-G motif; other site 481743006653 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743006654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743006655 active site 481743006656 phosphorylation site [posttranslational modification] 481743006657 intermolecular recognition site; other site 481743006658 dimerization interface [polypeptide binding]; other site 481743006659 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743006660 DNA binding residues [nucleotide binding] 481743006661 dimerization interface [polypeptide binding]; other site 481743006662 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 481743006663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743006664 putative substrate translocation pore; other site 481743006665 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481743006666 PAS domain; Region: PAS_9; pfam13426 481743006667 putative active site [active] 481743006668 heme pocket [chemical binding]; other site 481743006669 YwiC-like protein; Region: YwiC; pfam14256 481743006670 N-terminal catalytic domain of mainly uncharacterized eukaryotic proteins similar to alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like_1; cd10791 481743006671 putative active site [active] 481743006672 catalytic site [active] 481743006673 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 481743006674 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 481743006675 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 481743006676 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 481743006677 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743006678 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743006679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743006680 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 481743006681 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 481743006682 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 481743006683 TIGR01777 family protein; Region: yfcH 481743006684 putative NAD(P) binding site [chemical binding]; other site 481743006685 putative active site [active] 481743006686 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 481743006687 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 481743006688 inhibitor-cofactor binding pocket; inhibition site 481743006689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743006690 catalytic residue [active] 481743006691 Arginase family; Region: Arginase; cd09989 481743006692 agmatinase; Region: agmatinase; TIGR01230 481743006693 active site 481743006694 Mn binding site [ion binding]; other site 481743006695 oligomer interface [polypeptide binding]; other site 481743006696 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743006697 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 481743006698 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743006699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743006700 dimer interface [polypeptide binding]; other site 481743006701 conserved gate region; other site 481743006702 ABC-ATPase subunit interface; other site 481743006703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743006704 dimer interface [polypeptide binding]; other site 481743006705 conserved gate region; other site 481743006706 putative PBP binding loops; other site 481743006707 ABC-ATPase subunit interface; other site 481743006708 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743006709 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743006710 DNA binding site [nucleotide binding] 481743006711 domain linker motif; other site 481743006712 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 481743006713 dimerization interface [polypeptide binding]; other site 481743006714 ligand binding site [chemical binding]; other site 481743006715 sodium binding site [ion binding]; other site 481743006716 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 481743006717 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 481743006718 substrate binding site [chemical binding]; other site 481743006719 dimer interface [polypeptide binding]; other site 481743006720 ATP binding site [chemical binding]; other site 481743006721 D-ribose pyranase; Provisional; Region: PRK11797 481743006722 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 481743006723 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 481743006724 Walker A/P-loop; other site 481743006725 ATP binding site [chemical binding]; other site 481743006726 Q-loop/lid; other site 481743006727 ABC transporter signature motif; other site 481743006728 Walker B; other site 481743006729 D-loop; other site 481743006730 H-loop/switch region; other site 481743006731 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 481743006732 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481743006733 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 481743006734 TM-ABC transporter signature motif; other site 481743006735 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 481743006736 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 481743006737 ligand binding site [chemical binding]; other site 481743006738 dimerization interface [polypeptide binding]; other site 481743006739 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743006740 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743006741 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743006742 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 481743006743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743006744 active site 481743006745 phosphorylation site [posttranslational modification] 481743006746 intermolecular recognition site; other site 481743006747 dimerization interface [polypeptide binding]; other site 481743006748 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743006749 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743006750 Histidine kinase; Region: His_kinase; pfam06580 481743006751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743006752 ATP binding site [chemical binding]; other site 481743006753 Mg2+ binding site [ion binding]; other site 481743006754 G-X-G motif; other site 481743006755 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743006756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743006757 dimer interface [polypeptide binding]; other site 481743006758 conserved gate region; other site 481743006759 ABC-ATPase subunit interface; other site 481743006760 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743006761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743006762 dimer interface [polypeptide binding]; other site 481743006763 conserved gate region; other site 481743006764 putative PBP binding loops; other site 481743006765 ABC-ATPase subunit interface; other site 481743006766 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743006767 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743006768 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 481743006769 conserved cys residue [active] 481743006770 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743006771 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743006772 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743006773 cobyric acid synthase; Provisional; Region: PRK00784 481743006774 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 481743006775 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 481743006776 catalytic triad [active] 481743006777 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 481743006778 catalytic residues [active] 481743006779 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 481743006780 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 481743006781 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 481743006782 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 481743006783 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 481743006784 Ion channel; Region: Ion_trans_2; pfam07885 481743006785 TrkA-N domain; Region: TrkA_N; pfam02254 481743006786 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743006787 DNA-binding site [nucleotide binding]; DNA binding site 481743006788 HPP family; Region: HPP; pfam04982 481743006789 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 481743006790 HEAT repeats; Region: HEAT_2; pfam13646 481743006791 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 481743006792 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 481743006793 DXD motif; other site 481743006794 Response regulator receiver domain; Region: Response_reg; pfam00072 481743006795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743006796 active site 481743006797 phosphorylation site [posttranslational modification] 481743006798 intermolecular recognition site; other site 481743006799 dimerization interface [polypeptide binding]; other site 481743006800 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 481743006801 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 481743006802 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 481743006803 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 481743006804 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 481743006805 NodB motif; other site 481743006806 active site 481743006807 metal binding site [ion binding]; metal-binding site 481743006808 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 481743006809 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 481743006810 NodB motif; other site 481743006811 active site 481743006812 catalytic site [active] 481743006813 metal binding site [ion binding]; metal-binding site 481743006814 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 481743006815 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 481743006816 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 481743006817 PilZ domain; Region: PilZ; pfam07238 481743006818 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 481743006819 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 481743006820 DXD motif; other site 481743006821 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 481743006822 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 481743006823 active site 481743006824 Predicted membrane protein [Function unknown]; Region: COG1511 481743006825 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 481743006826 Predicted membrane protein [Function unknown]; Region: COG1511 481743006827 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 481743006828 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 481743006829 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 481743006830 ligand binding site [chemical binding]; other site 481743006831 flexible hinge region; other site 481743006832 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 481743006833 putative switch regulator; other site 481743006834 non-specific DNA interactions [nucleotide binding]; other site 481743006835 DNA binding site [nucleotide binding] 481743006836 sequence specific DNA binding site [nucleotide binding]; other site 481743006837 putative cAMP binding site [chemical binding]; other site 481743006838 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 481743006839 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 481743006840 heme-binding site [chemical binding]; other site 481743006841 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 481743006842 FAD binding pocket [chemical binding]; other site 481743006843 FAD binding motif [chemical binding]; other site 481743006844 phosphate binding motif [ion binding]; other site 481743006845 beta-alpha-beta structure motif; other site 481743006846 NAD binding pocket [chemical binding]; other site 481743006847 Heme binding pocket [chemical binding]; other site 481743006848 Uncharacterized conserved protein [Function unknown]; Region: COG1284 481743006849 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 481743006850 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 481743006851 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 481743006852 methionine sulfoxide reductase A; Provisional; Region: PRK14054 481743006853 methionine sulfoxide reductase B; Provisional; Region: PRK00222 481743006854 SelR domain; Region: SelR; pfam01641 481743006855 Uncharacterized conserved protein [Function unknown]; Region: COG0398 481743006856 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 481743006857 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 481743006858 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743006859 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743006860 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743006861 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743006862 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743006863 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743006864 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743006865 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743006866 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743006867 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 481743006868 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 481743006869 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 481743006870 conserved cys residue [active] 481743006871 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 481743006872 Fe-S cluster binding site [ion binding]; other site 481743006873 active site 481743006874 Predicted transcriptional regulators [Transcription]; Region: COG1733 481743006875 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 481743006876 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 481743006877 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 481743006878 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481743006879 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 481743006880 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 481743006881 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 481743006882 [2Fe-2S] cluster binding site [ion binding]; other site 481743006883 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 481743006884 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 481743006885 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 481743006886 ligand binding site [chemical binding]; other site 481743006887 flexible hinge region; other site 481743006888 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 481743006889 putative switch regulator; other site 481743006890 non-specific DNA interactions [nucleotide binding]; other site 481743006891 DNA binding site [nucleotide binding] 481743006892 sequence specific DNA binding site [nucleotide binding]; other site 481743006893 putative cAMP binding site [chemical binding]; other site 481743006894 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 481743006895 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 481743006896 putative catalytic cysteine [active] 481743006897 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 481743006898 putative active site [active] 481743006899 metal binding site [ion binding]; metal-binding site 481743006900 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 481743006901 Pyruvate formate lyase 1; Region: PFL1; cd01678 481743006902 coenzyme A binding site [chemical binding]; other site 481743006903 active site 481743006904 catalytic residues [active] 481743006905 glycine loop; other site 481743006906 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 481743006907 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743006908 FeS/SAM binding site; other site 481743006909 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743006910 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743006911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743006912 dimer interface [polypeptide binding]; other site 481743006913 conserved gate region; other site 481743006914 putative PBP binding loops; other site 481743006915 ABC-ATPase subunit interface; other site 481743006916 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743006917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743006918 dimer interface [polypeptide binding]; other site 481743006919 conserved gate region; other site 481743006920 putative PBP binding loops; other site 481743006921 ABC-ATPase subunit interface; other site 481743006922 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743006923 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743006924 dimerization interface [polypeptide binding]; other site 481743006925 Histidine kinase; Region: His_kinase; pfam06580 481743006926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743006927 ATP binding site [chemical binding]; other site 481743006928 Mg2+ binding site [ion binding]; other site 481743006929 G-X-G motif; other site 481743006930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743006931 Response regulator receiver domain; Region: Response_reg; pfam00072 481743006932 active site 481743006933 phosphorylation site [posttranslational modification] 481743006934 intermolecular recognition site; other site 481743006935 dimerization interface [polypeptide binding]; other site 481743006936 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743006937 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743006938 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743006939 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 481743006940 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 481743006941 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 481743006942 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743006943 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743006944 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743006945 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 481743006946 metal binding site 2 [ion binding]; metal-binding site 481743006947 putative DNA binding helix; other site 481743006948 metal binding site 1 [ion binding]; metal-binding site 481743006949 dimer interface [polypeptide binding]; other site 481743006950 structural Zn2+ binding site [ion binding]; other site 481743006951 Uncharacterized conserved protein [Function unknown]; Region: COG0759 481743006952 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 481743006953 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 481743006954 active site 481743006955 HIGH motif; other site 481743006956 KMSKS motif; other site 481743006957 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 481743006958 tRNA binding surface [nucleotide binding]; other site 481743006959 anticodon binding site; other site 481743006960 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 481743006961 dimer interface [polypeptide binding]; other site 481743006962 putative tRNA-binding site [nucleotide binding]; other site 481743006963 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 481743006964 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 481743006965 intersubunit interface [polypeptide binding]; other site 481743006966 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 481743006967 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 481743006968 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 481743006969 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 481743006970 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 481743006971 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481743006972 ABC-ATPase subunit interface; other site 481743006973 dimer interface [polypeptide binding]; other site 481743006974 putative PBP binding regions; other site 481743006975 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 481743006976 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 481743006977 manganese transport transcriptional regulator; Provisional; Region: PRK03902 481743006978 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 481743006979 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 481743006980 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743006981 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 481743006982 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 481743006983 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 481743006984 active site 481743006985 nucleophile elbow; other site 481743006986 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 481743006987 Conserved membrane protein YqhR; Region: YqhR; pfam11085 481743006988 Dehydroquinase class II; Region: DHquinase_II; pfam01220 481743006989 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 481743006990 trimer interface [polypeptide binding]; other site 481743006991 active site 481743006992 dimer interface [polypeptide binding]; other site 481743006993 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 481743006994 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 481743006995 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 481743006996 active site 481743006997 elongation factor P; Validated; Region: PRK00529 481743006998 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 481743006999 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 481743007000 RNA binding site [nucleotide binding]; other site 481743007001 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 481743007002 RNA binding site [nucleotide binding]; other site 481743007003 aspartate kinase; Reviewed; Region: PRK06635 481743007004 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 481743007005 putative nucleotide binding site [chemical binding]; other site 481743007006 putative catalytic residues [active] 481743007007 putative Mg ion binding site [ion binding]; other site 481743007008 putative aspartate binding site [chemical binding]; other site 481743007009 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 481743007010 putative allosteric regulatory site; other site 481743007011 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 481743007012 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 481743007013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 481743007014 Walker A motif; other site 481743007015 ATP binding site [chemical binding]; other site 481743007016 Walker B motif; other site 481743007017 arginine finger; other site 481743007018 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 481743007019 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 481743007020 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 481743007021 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 481743007022 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 481743007023 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 481743007024 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 481743007025 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 481743007026 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 481743007027 carboxyltransferase (CT) interaction site; other site 481743007028 biotinylation site [posttranslational modification]; other site 481743007029 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 481743007030 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 481743007031 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 481743007032 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 481743007033 Asp23 family; Region: Asp23; pfam03780 481743007034 Asp23 family; Region: Asp23; pfam03780 481743007035 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 481743007036 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 481743007037 putative RNA binding site [nucleotide binding]; other site 481743007038 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 481743007039 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 481743007040 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 481743007041 homodimer interface [polypeptide binding]; other site 481743007042 NADP binding site [chemical binding]; other site 481743007043 substrate binding site [chemical binding]; other site 481743007044 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 481743007045 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 481743007046 generic binding surface II; other site 481743007047 generic binding surface I; other site 481743007048 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 481743007049 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 481743007050 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 481743007051 substrate binding pocket [chemical binding]; other site 481743007052 chain length determination region; other site 481743007053 substrate-Mg2+ binding site; other site 481743007054 catalytic residues [active] 481743007055 aspartate-rich region 1; other site 481743007056 active site lid residues [active] 481743007057 aspartate-rich region 2; other site 481743007058 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 481743007059 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 481743007060 TPP-binding site; other site 481743007061 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 481743007062 PYR/PP interface [polypeptide binding]; other site 481743007063 dimer interface [polypeptide binding]; other site 481743007064 TPP binding site [chemical binding]; other site 481743007065 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 481743007066 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 481743007067 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 481743007068 RNA binding surface [nucleotide binding]; other site 481743007069 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 481743007070 arginine repressor; Provisional; Region: PRK04280 481743007071 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 481743007072 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 481743007073 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 481743007074 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 481743007075 Walker A/P-loop; other site 481743007076 ATP binding site [chemical binding]; other site 481743007077 Q-loop/lid; other site 481743007078 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 481743007079 ABC transporter signature motif; other site 481743007080 Walker B; other site 481743007081 D-loop; other site 481743007082 H-loop/switch region; other site 481743007083 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 481743007084 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 481743007085 protein binding site [polypeptide binding]; other site 481743007086 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 481743007087 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 481743007088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743007089 active site 481743007090 phosphorylation site [posttranslational modification] 481743007091 intermolecular recognition site; other site 481743007092 dimerization interface [polypeptide binding]; other site 481743007093 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 481743007094 Predicted transcriptional regulator [Transcription]; Region: COG4189 481743007095 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743007096 putative DNA binding site [nucleotide binding]; other site 481743007097 dimerization interface [polypeptide binding]; other site 481743007098 putative Zn2+ binding site [ion binding]; other site 481743007099 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743007100 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743007101 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 481743007102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743007103 dimer interface [polypeptide binding]; other site 481743007104 conserved gate region; other site 481743007105 putative PBP binding loops; other site 481743007106 ABC-ATPase subunit interface; other site 481743007107 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743007108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743007109 dimer interface [polypeptide binding]; other site 481743007110 conserved gate region; other site 481743007111 putative PBP binding loops; other site 481743007112 ABC-ATPase subunit interface; other site 481743007113 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 481743007114 active site 481743007115 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 481743007116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743007117 NAD(P) binding site [chemical binding]; other site 481743007118 active site 481743007119 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 481743007120 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 481743007121 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 481743007122 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481743007123 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 481743007124 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 481743007125 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 481743007126 tetramer interface [polypeptide binding]; other site 481743007127 TPP-binding site [chemical binding]; other site 481743007128 heterodimer interface [polypeptide binding]; other site 481743007129 phosphorylation loop region [posttranslational modification] 481743007130 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 481743007131 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 481743007132 alpha subunit interface [polypeptide binding]; other site 481743007133 TPP binding site [chemical binding]; other site 481743007134 heterodimer interface [polypeptide binding]; other site 481743007135 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 481743007136 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 481743007137 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 481743007138 E3 interaction surface; other site 481743007139 lipoyl attachment site [posttranslational modification]; other site 481743007140 e3 binding domain; Region: E3_binding; pfam02817 481743007141 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 481743007142 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 481743007143 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 481743007144 peptidase T-like protein; Region: PepT-like; TIGR01883 481743007145 metal binding site [ion binding]; metal-binding site 481743007146 putative dimer interface [polypeptide binding]; other site 481743007147 Tetratricopeptide repeat; Region: TPR_16; pfam13432 481743007148 Fungal fruit body lectin; Region: FB_lectin; pfam07367 481743007149 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 481743007150 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 481743007151 dimer interface [polypeptide binding]; other site 481743007152 ADP-ribose binding site [chemical binding]; other site 481743007153 active site 481743007154 nudix motif; other site 481743007155 metal binding site [ion binding]; metal-binding site 481743007156 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 481743007157 PHP-associated; Region: PHP_C; pfam13263 481743007158 Integral membrane protein DUF95; Region: DUF95; cl00572 481743007159 ferric uptake regulator; Provisional; Region: fur; PRK09462 481743007160 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 481743007161 metal binding site 2 [ion binding]; metal-binding site 481743007162 putative DNA binding helix; other site 481743007163 metal binding site 1 [ion binding]; metal-binding site 481743007164 dimer interface [polypeptide binding]; other site 481743007165 structural Zn2+ binding site [ion binding]; other site 481743007166 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 481743007167 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 481743007168 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 481743007169 active site 481743007170 Int/Topo IB signature motif; other site 481743007171 purine nucleoside phosphorylase; Provisional; Region: PRK08202 481743007172 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 481743007173 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 481743007174 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 481743007175 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 481743007176 anti sigma factor interaction site; other site 481743007177 regulatory phosphorylation site [posttranslational modification]; other site 481743007178 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 481743007179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743007180 ATP binding site [chemical binding]; other site 481743007181 Mg2+ binding site [ion binding]; other site 481743007182 G-X-G motif; other site 481743007183 sporulation sigma factor SigF; Validated; Region: PRK05572 481743007184 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743007185 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 481743007186 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743007187 DNA binding residues [nucleotide binding] 481743007188 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 481743007189 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 481743007190 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 481743007191 diaminopimelate decarboxylase; Region: lysA; TIGR01048 481743007192 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 481743007193 active site 481743007194 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 481743007195 substrate binding site [chemical binding]; other site 481743007196 catalytic residues [active] 481743007197 dimer interface [polypeptide binding]; other site 481743007198 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 481743007199 active site 481743007200 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 481743007201 active site 481743007202 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 481743007203 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 481743007204 catalytic motif [active] 481743007205 Zn binding site [ion binding]; other site 481743007206 RibD C-terminal domain; Region: RibD_C; cl17279 481743007207 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 481743007208 Lumazine binding domain; Region: Lum_binding; pfam00677 481743007209 Lumazine binding domain; Region: Lum_binding; pfam00677 481743007210 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 481743007211 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 481743007212 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 481743007213 dimerization interface [polypeptide binding]; other site 481743007214 active site 481743007215 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 481743007216 homopentamer interface [polypeptide binding]; other site 481743007217 active site 481743007218 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 481743007219 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 481743007220 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 481743007221 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 481743007222 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 481743007223 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 481743007224 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 481743007225 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 481743007226 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 481743007227 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 481743007228 RNA binding surface [nucleotide binding]; other site 481743007229 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 481743007230 active site 481743007231 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 481743007232 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 481743007233 catalytic residues [active] 481743007234 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 481743007235 ResB-like family; Region: ResB; pfam05140 481743007236 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 481743007237 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 481743007238 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743007239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743007240 active site 481743007241 phosphorylation site [posttranslational modification] 481743007242 intermolecular recognition site; other site 481743007243 dimerization interface [polypeptide binding]; other site 481743007244 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743007245 DNA binding site [nucleotide binding] 481743007246 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 481743007247 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743007248 dimerization interface [polypeptide binding]; other site 481743007249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743007250 dimer interface [polypeptide binding]; other site 481743007251 phosphorylation site [posttranslational modification] 481743007252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743007253 ATP binding site [chemical binding]; other site 481743007254 Mg2+ binding site [ion binding]; other site 481743007255 G-X-G motif; other site 481743007256 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 481743007257 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 481743007258 ligand binding site [chemical binding]; other site 481743007259 NAD binding site [chemical binding]; other site 481743007260 dimerization interface [polypeptide binding]; other site 481743007261 catalytic site [active] 481743007262 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 481743007263 putative L-serine binding site [chemical binding]; other site 481743007264 CAAX protease self-immunity; Region: Abi; pfam02517 481743007265 Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]; Region: CobN; COG1429 481743007266 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 481743007267 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 481743007268 putative active site [active] 481743007269 putative metal binding site [ion binding]; other site 481743007270 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 481743007271 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 481743007272 NodB motif; other site 481743007273 active site 481743007274 catalytic site [active] 481743007275 metal binding site [ion binding]; metal-binding site 481743007276 adaptor protein; Provisional; Region: PRK02899 481743007277 Protease prsW family; Region: PrsW-protease; pfam13367 481743007278 germination protein YpeB; Region: spore_YpeB; TIGR02889 481743007279 Flagellar protein YcgR; Region: YcgR_2; pfam12945 481743007280 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 481743007281 PilZ domain; Region: PilZ; pfam07238 481743007282 cytidylate kinase; Provisional; Region: cmk; PRK00023 481743007283 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 481743007284 CMP-binding site; other site 481743007285 The sites determining sugar specificity; other site 481743007286 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 481743007287 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 481743007288 putative acyl-acceptor binding pocket; other site 481743007289 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 481743007290 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 481743007291 RNA binding site [nucleotide binding]; other site 481743007292 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 481743007293 RNA binding site [nucleotide binding]; other site 481743007294 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 481743007295 RNA binding site [nucleotide binding]; other site 481743007296 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 481743007297 RNA binding site [nucleotide binding]; other site 481743007298 GTP-binding protein Der; Reviewed; Region: PRK00093 481743007299 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 481743007300 G1 box; other site 481743007301 GTP/Mg2+ binding site [chemical binding]; other site 481743007302 Switch I region; other site 481743007303 G2 box; other site 481743007304 Switch II region; other site 481743007305 G3 box; other site 481743007306 G4 box; other site 481743007307 G5 box; other site 481743007308 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 481743007309 G1 box; other site 481743007310 GTP/Mg2+ binding site [chemical binding]; other site 481743007311 Switch I region; other site 481743007312 G2 box; other site 481743007313 G3 box; other site 481743007314 Switch II region; other site 481743007315 G4 box; other site 481743007316 G5 box; other site 481743007317 membrane protein; Provisional; Region: PRK14405 481743007318 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 481743007319 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 481743007320 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 481743007321 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 481743007322 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 481743007323 catalytic loop [active] 481743007324 iron binding site [ion binding]; other site 481743007325 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 481743007326 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 481743007327 G1 box; other site 481743007328 GTP/Mg2+ binding site [chemical binding]; other site 481743007329 G2 box; other site 481743007330 Switch I region; other site 481743007331 G3 box; other site 481743007332 Switch II region; other site 481743007333 G5 box; other site 481743007334 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 481743007335 IHF - DNA interface [nucleotide binding]; other site 481743007336 IHF dimer interface [polypeptide binding]; other site 481743007337 transcription attenuation protein MtrB; Provisional; Region: PRK13251 481743007338 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 481743007339 UbiA prenyltransferase family; Region: UbiA; pfam01040 481743007340 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 481743007341 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 481743007342 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 481743007343 UbiA prenyltransferase family; Region: UbiA; pfam01040 481743007344 aromatic acid decarboxylase; Validated; Region: PRK05920 481743007345 Flavoprotein; Region: Flavoprotein; pfam02441 481743007346 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 481743007347 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 481743007348 substrate binding pocket [chemical binding]; other site 481743007349 chain length determination region; other site 481743007350 substrate-Mg2+ binding site; other site 481743007351 catalytic residues [active] 481743007352 aspartate-rich region 1; other site 481743007353 active site lid residues [active] 481743007354 aspartate-rich region 2; other site 481743007355 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 481743007356 active site 481743007357 multimer interface [polypeptide binding]; other site 481743007358 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 481743007359 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 481743007360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743007361 S-adenosylmethionine binding site [chemical binding]; other site 481743007362 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 481743007363 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 481743007364 Tetramer interface [polypeptide binding]; other site 481743007365 active site 481743007366 FMN-binding site [chemical binding]; other site 481743007367 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 481743007368 active site 481743007369 dimer interface [polypeptide binding]; other site 481743007370 metal binding site [ion binding]; metal-binding site 481743007371 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 481743007372 homotrimer interaction site [polypeptide binding]; other site 481743007373 active site 481743007374 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 481743007375 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 481743007376 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 481743007377 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 481743007378 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 481743007379 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 481743007380 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 481743007381 active site 481743007382 ribulose/triose binding site [chemical binding]; other site 481743007383 phosphate binding site [ion binding]; other site 481743007384 substrate (anthranilate) binding pocket [chemical binding]; other site 481743007385 product (indole) binding pocket [chemical binding]; other site 481743007386 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 481743007387 active site 481743007388 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 481743007389 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 481743007390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743007391 catalytic residue [active] 481743007392 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 481743007393 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 481743007394 substrate binding site [chemical binding]; other site 481743007395 active site 481743007396 catalytic residues [active] 481743007397 heterodimer interface [polypeptide binding]; other site 481743007398 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 481743007399 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743007400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743007401 homodimer interface [polypeptide binding]; other site 481743007402 catalytic residue [active] 481743007403 prephenate dehydrogenase; Validated; Region: PRK08507 481743007404 prephenate dehydrogenase; Validated; Region: PRK06545 481743007405 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 481743007406 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 481743007407 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743007408 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743007409 DNA binding residues [nucleotide binding] 481743007410 Putative zinc-finger; Region: zf-HC2; pfam13490 481743007411 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 481743007412 catalytic core [active] 481743007413 Methyltransferase domain; Region: Methyltransf_31; pfam13847 481743007414 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743007415 S-adenosylmethionine binding site [chemical binding]; other site 481743007416 IDEAL domain; Region: IDEAL; cl07452 481743007417 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 481743007418 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 481743007419 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 481743007420 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 481743007421 iron-sulfur cluster [ion binding]; other site 481743007422 [2Fe-2S] cluster binding site [ion binding]; other site 481743007423 cytochrome b6; Provisional; Region: PRK03735 481743007424 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 481743007425 interchain domain interface [polypeptide binding]; other site 481743007426 intrachain domain interface; other site 481743007427 heme bH binding site [chemical binding]; other site 481743007428 Qi binding site; other site 481743007429 heme bL binding site [chemical binding]; other site 481743007430 Qo binding site; other site 481743007431 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 481743007432 intrachain domain interface; other site 481743007433 Qo binding site; other site 481743007434 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 481743007435 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 481743007436 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 481743007437 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 481743007438 Uncharacterized conserved protein [Function unknown]; Region: COG1284 481743007439 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 481743007440 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 481743007441 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 481743007442 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 481743007443 homodimer interface [polypeptide binding]; other site 481743007444 metal binding site [ion binding]; metal-binding site 481743007445 dihydrodipicolinate reductase; Provisional; Region: PRK00048 481743007446 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 481743007447 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 481743007448 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 481743007449 active site 481743007450 dimer interfaces [polypeptide binding]; other site 481743007451 catalytic residues [active] 481743007452 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 481743007453 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 481743007454 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 481743007455 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 481743007456 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 481743007457 active site 481743007458 NTP binding site [chemical binding]; other site 481743007459 metal binding triad [ion binding]; metal-binding site 481743007460 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 481743007461 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 481743007462 Biotin operon repressor [Transcription]; Region: BirA; COG1654 481743007463 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 481743007464 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 481743007465 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 481743007466 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 481743007467 oligomerization interface [polypeptide binding]; other site 481743007468 active site 481743007469 metal binding site [ion binding]; metal-binding site 481743007470 pantoate--beta-alanine ligase; Region: panC; TIGR00018 481743007471 Pantoate-beta-alanine ligase; Region: PanC; cd00560 481743007472 active site 481743007473 ATP-binding site [chemical binding]; other site 481743007474 pantoate-binding site; other site 481743007475 HXXH motif; other site 481743007476 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 481743007477 tetramerization interface [polypeptide binding]; other site 481743007478 active site 481743007479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743007480 TPR motif; other site 481743007481 binding surface 481743007482 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 481743007483 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 481743007484 active site 481743007485 catalytic site [active] 481743007486 substrate binding site [chemical binding]; other site 481743007487 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 481743007488 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481743007489 putative Mg++ binding site [ion binding]; other site 481743007490 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 481743007491 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 481743007492 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 481743007493 CoA binding domain; Region: CoA_binding; pfam02629 481743007494 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 481743007495 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 481743007496 active site 481743007497 putative substrate binding pocket [chemical binding]; other site 481743007498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 481743007499 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 481743007500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743007501 Walker A motif; other site 481743007502 ATP binding site [chemical binding]; other site 481743007503 Walker B motif; other site 481743007504 arginine finger; other site 481743007505 Peptidase family M41; Region: Peptidase_M41; pfam01434 481743007506 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 481743007507 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 481743007508 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 481743007509 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 481743007510 propionate/acetate kinase; Provisional; Region: PRK12379 481743007511 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 481743007512 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 481743007513 putative dimer interface [polypeptide binding]; other site 481743007514 putative anticodon binding site; other site 481743007515 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 481743007516 homodimer interface [polypeptide binding]; other site 481743007517 motif 1; other site 481743007518 motif 2; other site 481743007519 active site 481743007520 motif 3; other site 481743007521 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 481743007522 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 481743007523 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 481743007524 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743007525 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743007526 DNA binding residues [nucleotide binding] 481743007527 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 481743007528 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743007529 motif II; other site 481743007530 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 481743007531 Eukaryotic phosphomannomutase; Region: PMM; cl17107 481743007532 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743007533 motif II; other site 481743007534 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743007535 active site 481743007536 substrate binding site [chemical binding]; other site 481743007537 ATP binding site [chemical binding]; other site 481743007538 CAAX protease self-immunity; Region: Abi; pfam02517 481743007539 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 481743007540 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743007541 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743007542 DNA binding residues [nucleotide binding] 481743007543 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 481743007544 intersubunit interface [polypeptide binding]; other site 481743007545 active site 481743007546 Zn2+ binding site [ion binding]; other site 481743007547 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 481743007548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743007549 active site 481743007550 motif I; other site 481743007551 motif II; other site 481743007552 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 481743007553 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 481743007554 dimer interface [polypeptide binding]; other site 481743007555 active site 481743007556 catalytic residue [active] 481743007557 metal binding site [ion binding]; metal-binding site 481743007558 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 481743007559 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 481743007560 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 481743007561 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 481743007562 putative catalytic cysteine [active] 481743007563 gamma-glutamyl kinase; Provisional; Region: PRK05429 481743007564 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 481743007565 nucleotide binding site [chemical binding]; other site 481743007566 homotetrameric interface [polypeptide binding]; other site 481743007567 putative phosphate binding site [ion binding]; other site 481743007568 putative allosteric binding site; other site 481743007569 PUA domain; Region: PUA; pfam01472 481743007570 transaminase; Reviewed; Region: PRK08068 481743007571 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743007572 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743007573 homodimer interface [polypeptide binding]; other site 481743007574 catalytic residue [active] 481743007575 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 481743007576 Predicted amidohydrolase [General function prediction only]; Region: COG0388 481743007577 putative active site [active] 481743007578 catalytic triad [active] 481743007579 putative dimer interface [polypeptide binding]; other site 481743007580 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743007581 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743007582 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 481743007583 dimerization interface [polypeptide binding]; other site 481743007584 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 481743007585 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 481743007586 substrate binding site [chemical binding]; other site 481743007587 ligand binding site [chemical binding]; other site 481743007588 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 481743007589 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 481743007590 substrate binding site [chemical binding]; other site 481743007591 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743007592 AMIN domain; Region: AMIN; pfam11741 481743007593 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 481743007594 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 481743007595 active site 481743007596 metal binding site [ion binding]; metal-binding site 481743007597 Sporulation and spore germination; Region: Germane; pfam10646 481743007598 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743007599 AMIN domain; Region: AMIN; pfam11741 481743007600 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 481743007601 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 481743007602 active site 481743007603 metal binding site [ion binding]; metal-binding site 481743007604 Sporulation and spore germination; Region: Germane; pfam10646 481743007605 S-layer homology domain; Region: SLH; pfam00395 481743007606 S-layer homology domain; Region: SLH; pfam00395 481743007607 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 481743007608 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 481743007609 minor groove reading motif; other site 481743007610 helix-hairpin-helix signature motif; other site 481743007611 substrate binding pocket [chemical binding]; other site 481743007612 active site 481743007613 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 481743007614 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 481743007615 Dynamin family; Region: Dynamin_N; pfam00350 481743007616 G1 box; other site 481743007617 GTP/Mg2+ binding site [chemical binding]; other site 481743007618 G2 box; other site 481743007619 Switch I region; other site 481743007620 G3 box; other site 481743007621 Switch II region; other site 481743007622 G4 box; other site 481743007623 G5 box; other site 481743007624 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 481743007625 Dynamin family; Region: Dynamin_N; pfam00350 481743007626 G1 box; other site 481743007627 GTP/Mg2+ binding site [chemical binding]; other site 481743007628 G2 box; other site 481743007629 Switch I region; other site 481743007630 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 481743007631 G3 box; other site 481743007632 Switch II region; other site 481743007633 GTP/Mg2+ binding site [chemical binding]; other site 481743007634 G4 box; other site 481743007635 G5 box; other site 481743007636 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743007637 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743007638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743007639 Walker A/P-loop; other site 481743007640 ATP binding site [chemical binding]; other site 481743007641 Q-loop/lid; other site 481743007642 ABC transporter signature motif; other site 481743007643 Walker B; other site 481743007644 D-loop; other site 481743007645 H-loop/switch region; other site 481743007646 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743007647 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743007648 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 481743007649 Walker A/P-loop; other site 481743007650 ATP binding site [chemical binding]; other site 481743007651 Q-loop/lid; other site 481743007652 ABC transporter signature motif; other site 481743007653 Walker B; other site 481743007654 D-loop; other site 481743007655 H-loop/switch region; other site 481743007656 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 481743007657 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743007658 Coenzyme A binding pocket [chemical binding]; other site 481743007659 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 481743007660 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 481743007661 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 481743007662 active site 481743007663 catalytic triad [active] 481743007664 oxyanion hole [active] 481743007665 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743007666 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 481743007667 Walker A/P-loop; other site 481743007668 ATP binding site [chemical binding]; other site 481743007669 Q-loop/lid; other site 481743007670 ABC transporter signature motif; other site 481743007671 Walker B; other site 481743007672 D-loop; other site 481743007673 H-loop/switch region; other site 481743007674 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 481743007675 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 481743007676 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 481743007677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743007678 ATP binding site [chemical binding]; other site 481743007679 Mg2+ binding site [ion binding]; other site 481743007680 G-X-G motif; other site 481743007681 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 481743007682 anchoring element; other site 481743007683 dimer interface [polypeptide binding]; other site 481743007684 ATP binding site [chemical binding]; other site 481743007685 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 481743007686 active site 481743007687 putative metal-binding site [ion binding]; other site 481743007688 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 481743007689 DNA gyrase subunit A; Validated; Region: PRK05560 481743007690 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 481743007691 CAP-like domain; other site 481743007692 active site 481743007693 primary dimer interface [polypeptide binding]; other site 481743007694 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 481743007695 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 481743007696 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 481743007697 Transcriptional regulators [Transcription]; Region: MarR; COG1846 481743007698 MarR family; Region: MarR; pfam01047 481743007699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 481743007700 Chitin binding domain; Region: Chitin_bind_3; pfam03067 481743007701 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 481743007702 Interdomain contacts; other site 481743007703 Cytokine receptor motif; other site 481743007704 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 481743007705 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 481743007706 Interdomain contacts; other site 481743007707 Cytokine receptor motif; other site 481743007708 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 481743007709 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 481743007710 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 481743007711 active site 481743007712 Methyltransferase domain; Region: Methyltransf_26; pfam13659 481743007713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743007714 Coenzyme A binding pocket [chemical binding]; other site 481743007715 MutS domain III; Region: MutS_III; pfam05192 481743007716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743007717 Walker A/P-loop; other site 481743007718 ATP binding site [chemical binding]; other site 481743007719 Q-loop/lid; other site 481743007720 ABC transporter signature motif; other site 481743007721 Walker B; other site 481743007722 D-loop; other site 481743007723 H-loop/switch region; other site 481743007724 oligoendopeptidase F; Region: pepF; TIGR00181 481743007725 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 481743007726 active site 481743007727 Zn binding site [ion binding]; other site 481743007728 PAS domain S-box; Region: sensory_box; TIGR00229 481743007729 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481743007730 putative active site [active] 481743007731 heme pocket [chemical binding]; other site 481743007732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481743007733 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 481743007734 putative active site [active] 481743007735 heme pocket [chemical binding]; other site 481743007736 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481743007737 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 481743007738 putative active site [active] 481743007739 heme pocket [chemical binding]; other site 481743007740 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481743007741 putative active site [active] 481743007742 heme pocket [chemical binding]; other site 481743007743 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481743007744 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 481743007745 putative active site [active] 481743007746 heme pocket [chemical binding]; other site 481743007747 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743007748 dimer interface [polypeptide binding]; other site 481743007749 phosphorylation site [posttranslational modification] 481743007750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743007751 ATP binding site [chemical binding]; other site 481743007752 Mg2+ binding site [ion binding]; other site 481743007753 G-X-G motif; other site 481743007754 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743007755 Coenzyme A binding pocket [chemical binding]; other site 481743007756 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 481743007757 putative dimer interface [polypeptide binding]; other site 481743007758 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743007759 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743007760 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743007761 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481743007762 active site 481743007763 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481743007764 catalytic tetrad [active] 481743007765 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743007766 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743007767 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743007768 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743007769 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743007770 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743007771 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 481743007772 hypothetical protein; Provisional; Region: PRK11281 481743007773 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 481743007774 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 481743007775 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 481743007776 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 481743007777 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 481743007778 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481743007779 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 481743007780 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 481743007781 active site residue [active] 481743007782 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 481743007783 putative homodimer interface [polypeptide binding]; other site 481743007784 putative homotetramer interface [polypeptide binding]; other site 481743007785 putative metal binding site [ion binding]; other site 481743007786 putative homodimer-homodimer interface [polypeptide binding]; other site 481743007787 putative allosteric switch controlling residues; other site 481743007788 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 481743007789 CPxP motif; other site 481743007790 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 481743007791 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 481743007792 active site residue [active] 481743007793 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 481743007794 active site residue [active] 481743007795 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 481743007796 CPxP motif; other site 481743007797 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 481743007798 active site residue [active] 481743007799 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 481743007800 active site residue [active] 481743007801 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 481743007802 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 481743007803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743007804 S-adenosylmethionine binding site [chemical binding]; other site 481743007805 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743007806 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743007807 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 481743007808 Sulfatase; Region: Sulfatase; pfam00884 481743007809 gliding motility-associated lipoprotein GldK; Region: GldK_short; TIGR03529 481743007810 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 481743007811 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743007812 active site 481743007813 substrate binding site [chemical binding]; other site 481743007814 ATP binding site [chemical binding]; other site 481743007815 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 481743007816 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 481743007817 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 481743007818 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 481743007819 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 481743007820 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743007821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743007822 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 481743007823 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 481743007824 Tim44-like domain; Region: Tim44; cl09208 481743007825 Predicted transcriptional regulators [Transcription]; Region: COG1695 481743007826 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 481743007827 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 481743007828 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 481743007829 active site clefts [active] 481743007830 zinc binding site [ion binding]; other site 481743007831 dimer interface [polypeptide binding]; other site 481743007832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 481743007833 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 481743007834 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 481743007835 active site 481743007836 Zn binding site [ion binding]; other site 481743007837 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 481743007838 NMT1-like family; Region: NMT1_2; pfam13379 481743007839 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 481743007840 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 481743007841 Walker A/P-loop; other site 481743007842 ATP binding site [chemical binding]; other site 481743007843 Q-loop/lid; other site 481743007844 ABC transporter signature motif; other site 481743007845 Walker B; other site 481743007846 D-loop; other site 481743007847 H-loop/switch region; other site 481743007848 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 481743007849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743007850 dimer interface [polypeptide binding]; other site 481743007851 conserved gate region; other site 481743007852 putative PBP binding loops; other site 481743007853 ABC-ATPase subunit interface; other site 481743007854 Predicted membrane protein [Function unknown]; Region: COG4129 481743007855 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 481743007856 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 481743007857 Outer spore coat protein E (CotE); Region: CotE; pfam10628 481743007858 Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395 481743007859 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 481743007860 MutS domain I; Region: MutS_I; pfam01624 481743007861 MutS domain II; Region: MutS_II; pfam05188 481743007862 MutS domain III; Region: MutS_III; pfam05192 481743007863 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 481743007864 Walker A/P-loop; other site 481743007865 ATP binding site [chemical binding]; other site 481743007866 Q-loop/lid; other site 481743007867 ABC transporter signature motif; other site 481743007868 Walker B; other site 481743007869 D-loop; other site 481743007870 H-loop/switch region; other site 481743007871 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 481743007872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743007873 ATP binding site [chemical binding]; other site 481743007874 Mg2+ binding site [ion binding]; other site 481743007875 G-X-G motif; other site 481743007876 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 481743007877 ATP binding site [chemical binding]; other site 481743007878 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 481743007879 Brix domain; Region: Brix; cl00935 481743007880 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 481743007881 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 481743007882 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 481743007883 bacterial Hfq-like; Region: Hfq; cd01716 481743007884 hexamer interface [polypeptide binding]; other site 481743007885 Sm1 motif; other site 481743007886 RNA binding site [nucleotide binding]; other site 481743007887 Sm2 motif; other site 481743007888 Transglycosylase; Region: Transgly; pfam00912 481743007889 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 481743007890 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 481743007891 Protein of unknown function (DUF402); Region: DUF402; cl00979 481743007892 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 481743007893 Uncharacterized conserved protein [Function unknown]; Region: COG1434 481743007894 putative active site [active] 481743007895 stage V sporulation protein K; Region: spore_V_K; TIGR02881 481743007896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743007897 Walker A motif; other site 481743007898 ATP binding site [chemical binding]; other site 481743007899 Walker B motif; other site 481743007900 arginine finger; other site 481743007901 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 481743007902 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 481743007903 HflX GTPase family; Region: HflX; cd01878 481743007904 G1 box; other site 481743007905 GTP/Mg2+ binding site [chemical binding]; other site 481743007906 Switch I region; other site 481743007907 G2 box; other site 481743007908 G3 box; other site 481743007909 Switch II region; other site 481743007910 G4 box; other site 481743007911 G5 box; other site 481743007912 Aluminium resistance protein; Region: Alum_res; pfam06838 481743007913 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 481743007914 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 481743007915 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 481743007916 DNA binding residues [nucleotide binding] 481743007917 putative dimer interface [polypeptide binding]; other site 481743007918 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 481743007919 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 481743007920 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 481743007921 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 481743007922 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743007923 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743007924 DNA binding residues [nucleotide binding] 481743007925 Zonular occludens toxin (Zot); Region: Zot; cl17485 481743007926 LexA repressor; Validated; Region: PRK00215 481743007927 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743007928 putative DNA binding site [nucleotide binding]; other site 481743007929 putative Zn2+ binding site [ion binding]; other site 481743007930 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 481743007931 Catalytic site [active] 481743007932 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 481743007933 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 481743007934 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 481743007935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743007936 motif II; other site 481743007937 YtkA-like; Region: YtkA; pfam13115 481743007938 ARD/ARD' family; Region: ARD; pfam03079 481743007939 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 481743007940 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 481743007941 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 481743007942 substrate binding pocket [chemical binding]; other site 481743007943 dimer interface [polypeptide binding]; other site 481743007944 inhibitor binding site; inhibition site 481743007945 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 481743007946 B12 binding site [chemical binding]; other site 481743007947 cobalt ligand [ion binding]; other site 481743007948 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 481743007949 ribonuclease Z; Region: RNase_Z; TIGR02651 481743007950 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 481743007951 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743007952 active site 481743007953 motif I; other site 481743007954 motif II; other site 481743007955 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743007956 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 481743007957 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 481743007958 putative DNA binding site [nucleotide binding]; other site 481743007959 catalytic residue [active] 481743007960 putative H2TH interface [polypeptide binding]; other site 481743007961 putative catalytic residues [active] 481743007962 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 481743007963 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 481743007964 AP endonuclease family 2; Region: AP2Ec; smart00518 481743007965 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 481743007966 AP (apurinic/apyrimidinic) site pocket; other site 481743007967 DNA interaction; other site 481743007968 Metal-binding active site; metal-binding site 481743007969 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 481743007970 catalytic residues [active] 481743007971 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 481743007972 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481743007973 Walker A/P-loop; other site 481743007974 ATP binding site [chemical binding]; other site 481743007975 Q-loop/lid; other site 481743007976 ABC transporter signature motif; other site 481743007977 Walker B; other site 481743007978 D-loop; other site 481743007979 H-loop/switch region; other site 481743007980 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 481743007981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743007982 S-adenosylmethionine binding site [chemical binding]; other site 481743007983 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 481743007984 Catalytic domain of Protein Kinases; Region: PKc; cd00180 481743007985 active site 481743007986 ATP binding site [chemical binding]; other site 481743007987 substrate binding site [chemical binding]; other site 481743007988 activation loop (A-loop); other site 481743007989 AAA domain; Region: AAA_31; pfam13614 481743007990 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 481743007991 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 481743007992 AAA domain; Region: AAA_31; pfam13614 481743007993 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 481743007994 Walker A motif; other site 481743007995 ATP binding site [chemical binding]; other site 481743007996 Walker B motif; other site 481743007997 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 481743007998 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481743007999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743008000 Walker A/P-loop; other site 481743008001 ATP binding site [chemical binding]; other site 481743008002 Q-loop/lid; other site 481743008003 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481743008004 ABC transporter signature motif; other site 481743008005 Walker B; other site 481743008006 D-loop; other site 481743008007 ABC transporter; Region: ABC_tran_2; pfam12848 481743008008 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481743008009 Phosphotransferase enzyme family; Region: APH; pfam01636 481743008010 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 481743008011 active site 481743008012 ATP binding site [chemical binding]; other site 481743008013 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 481743008014 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 481743008015 ATP binding site [chemical binding]; other site 481743008016 substrate interface [chemical binding]; other site 481743008017 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 481743008018 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 481743008019 sugar binding site [chemical binding]; other site 481743008020 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 481743008021 sugar binding site [chemical binding]; other site 481743008022 CARDB; Region: CARDB; pfam07705 481743008023 CARDB; Region: CARDB; pfam07705 481743008024 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 481743008025 putative metal binding site [ion binding]; other site 481743008026 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 481743008027 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743008028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743008029 active site 481743008030 phosphorylation site [posttranslational modification] 481743008031 intermolecular recognition site; other site 481743008032 dimerization interface [polypeptide binding]; other site 481743008033 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743008034 DNA binding site [nucleotide binding] 481743008035 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 481743008036 NlpC/P60 family; Region: NLPC_P60; pfam00877 481743008037 Thiamine pyrophosphokinase; Region: TPK; cd07995 481743008038 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 481743008039 active site 481743008040 dimerization interface [polypeptide binding]; other site 481743008041 thiamine binding site [chemical binding]; other site 481743008042 UPF0126 domain; Region: UPF0126; pfam03458 481743008043 Predicted membrane protein [Function unknown]; Region: COG2860 481743008044 UPF0126 domain; Region: UPF0126; pfam03458 481743008045 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 481743008046 Low molecular weight phosphatase family; Region: LMWPc; cd00115 481743008047 active site 481743008048 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 481743008049 Putative esterase; Region: Esterase; pfam00756 481743008050 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 481743008051 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 481743008052 TPP-binding site [chemical binding]; other site 481743008053 heterodimer interface [polypeptide binding]; other site 481743008054 tetramer interface [polypeptide binding]; other site 481743008055 phosphorylation loop region [posttranslational modification] 481743008056 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 481743008057 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 481743008058 alpha subunit interface [polypeptide binding]; other site 481743008059 TPP binding site [chemical binding]; other site 481743008060 heterodimer interface [polypeptide binding]; other site 481743008061 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 481743008062 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 481743008063 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 481743008064 E3 interaction surface; other site 481743008065 lipoyl attachment site [posttranslational modification]; other site 481743008066 e3 binding domain; Region: E3_binding; pfam02817 481743008067 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 481743008068 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 481743008069 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 481743008070 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481743008071 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 481743008072 thymidylate synthase; Reviewed; Region: thyA; PRK01827 481743008073 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 481743008074 dimerization interface [polypeptide binding]; other site 481743008075 active site 481743008076 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 481743008077 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 481743008078 folate binding site [chemical binding]; other site 481743008079 NADP+ binding site [chemical binding]; other site 481743008080 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 481743008081 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 481743008082 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 481743008083 DNA topoisomerase III; Provisional; Region: PRK07726 481743008084 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 481743008085 active site 481743008086 putative interdomain interaction site [polypeptide binding]; other site 481743008087 putative metal-binding site [ion binding]; other site 481743008088 putative nucleotide binding site [chemical binding]; other site 481743008089 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 481743008090 domain I; other site 481743008091 DNA binding groove [nucleotide binding] 481743008092 phosphate binding site [ion binding]; other site 481743008093 domain II; other site 481743008094 domain III; other site 481743008095 nucleotide binding site [chemical binding]; other site 481743008096 catalytic site [active] 481743008097 domain IV; other site 481743008098 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 481743008099 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 481743008100 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743008101 motif II; other site 481743008102 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743008103 putative DNA binding site [nucleotide binding]; other site 481743008104 dimerization interface [polypeptide binding]; other site 481743008105 putative Zn2+ binding site [ion binding]; other site 481743008106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743008107 putative substrate translocation pore; other site 481743008108 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743008109 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 481743008110 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743008111 Walker A/P-loop; other site 481743008112 ATP binding site [chemical binding]; other site 481743008113 Q-loop/lid; other site 481743008114 ABC transporter signature motif; other site 481743008115 Walker B; other site 481743008116 D-loop; other site 481743008117 H-loop/switch region; other site 481743008118 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743008119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743008120 active site 481743008121 phosphorylation site [posttranslational modification] 481743008122 intermolecular recognition site; other site 481743008123 dimerization interface [polypeptide binding]; other site 481743008124 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743008125 DNA binding site [nucleotide binding] 481743008126 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 481743008127 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743008128 dimerization interface [polypeptide binding]; other site 481743008129 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743008130 dimer interface [polypeptide binding]; other site 481743008131 phosphorylation site [posttranslational modification] 481743008132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743008133 ATP binding site [chemical binding]; other site 481743008134 Mg2+ binding site [ion binding]; other site 481743008135 G-X-G motif; other site 481743008136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743008137 Coenzyme A binding pocket [chemical binding]; other site 481743008138 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 481743008139 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 481743008140 ligand binding site; other site 481743008141 oligomer interface; other site 481743008142 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 481743008143 N-terminal domain interface [polypeptide binding]; other site 481743008144 sulfate 1 binding site; other site 481743008145 glycogen branching enzyme; Provisional; Region: PRK12313 481743008146 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 481743008147 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 481743008148 active site 481743008149 catalytic site [active] 481743008150 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 481743008151 glycogen synthase; Provisional; Region: glgA; PRK00654 481743008152 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 481743008153 ADP-binding pocket [chemical binding]; other site 481743008154 homodimer interface [polypeptide binding]; other site 481743008155 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 481743008156 homodimer interface [polypeptide binding]; other site 481743008157 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 481743008158 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 481743008159 active site 481743008160 homodimer interface [polypeptide binding]; other site 481743008161 catalytic site [active] 481743008162 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481743008163 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 481743008164 substrate binding pocket [chemical binding]; other site 481743008165 membrane-bound complex binding site; other site 481743008166 hinge residues; other site 481743008167 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 481743008168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743008169 dimer interface [polypeptide binding]; other site 481743008170 conserved gate region; other site 481743008171 putative PBP binding loops; other site 481743008172 ABC-ATPase subunit interface; other site 481743008173 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 481743008174 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 481743008175 Walker A/P-loop; other site 481743008176 ATP binding site [chemical binding]; other site 481743008177 Q-loop/lid; other site 481743008178 ABC transporter signature motif; other site 481743008179 Walker B; other site 481743008180 D-loop; other site 481743008181 H-loop/switch region; other site 481743008182 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 481743008183 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 481743008184 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 481743008185 3D domain; Region: 3D; cl01439 481743008186 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 481743008187 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 481743008188 NodB motif; other site 481743008189 active site 481743008190 catalytic site [active] 481743008191 metal binding site [ion binding]; metal-binding site 481743008192 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 481743008193 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 481743008194 active site 481743008195 FMN binding site [chemical binding]; other site 481743008196 substrate binding site [chemical binding]; other site 481743008197 homotetramer interface [polypeptide binding]; other site 481743008198 catalytic residue [active] 481743008199 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 481743008200 Predicted membrane protein [Function unknown]; Region: COG3766 481743008201 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 481743008202 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 481743008203 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 481743008204 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 481743008205 dimer interface [polypeptide binding]; other site 481743008206 putative functional site; other site 481743008207 putative MPT binding site; other site 481743008208 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 481743008209 Walker A motif; other site 481743008210 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 481743008211 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 481743008212 active site 481743008213 DNA binding site [nucleotide binding] 481743008214 Int/Topo IB signature motif; other site 481743008215 Predicted acetyltransferase [General function prediction only]; Region: COG5628 481743008216 tropinone reductase; Provisional; Region: PRK09242 481743008217 classical (c) SDRs; Region: SDR_c; cd05233 481743008218 NAD(P) binding site [chemical binding]; other site 481743008219 active site 481743008220 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481743008221 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481743008222 active site 481743008223 catalytic tetrad [active] 481743008224 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 481743008225 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 481743008226 Interdomain contacts; other site 481743008227 Cytokine receptor motif; other site 481743008228 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 481743008229 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 481743008230 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743008231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743008232 dimer interface [polypeptide binding]; other site 481743008233 conserved gate region; other site 481743008234 ABC-ATPase subunit interface; other site 481743008235 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743008236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743008237 dimer interface [polypeptide binding]; other site 481743008238 conserved gate region; other site 481743008239 ABC-ATPase subunit interface; other site 481743008240 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743008241 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743008242 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743008243 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743008244 dimerization interface [polypeptide binding]; other site 481743008245 Histidine kinase; Region: His_kinase; pfam06580 481743008246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743008247 ATP binding site [chemical binding]; other site 481743008248 Mg2+ binding site [ion binding]; other site 481743008249 G-X-G motif; other site 481743008250 Response regulator receiver domain; Region: Response_reg; pfam00072 481743008251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743008252 active site 481743008253 phosphorylation site [posttranslational modification] 481743008254 intermolecular recognition site; other site 481743008255 dimerization interface [polypeptide binding]; other site 481743008256 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743008257 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743008258 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743008259 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743008260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743008261 dimer interface [polypeptide binding]; other site 481743008262 ABC-ATPase subunit interface; other site 481743008263 putative PBP binding loops; other site 481743008264 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743008265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743008266 dimer interface [polypeptide binding]; other site 481743008267 conserved gate region; other site 481743008268 putative PBP binding loops; other site 481743008269 ABC-ATPase subunit interface; other site 481743008270 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 481743008271 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 481743008272 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481743008273 MarR family; Region: MarR; pfam01047 481743008274 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 481743008275 NADH(P)-binding; Region: NAD_binding_10; pfam13460 481743008276 NAD binding site [chemical binding]; other site 481743008277 substrate binding site [chemical binding]; other site 481743008278 putative active site [active] 481743008279 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 481743008280 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 481743008281 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 481743008282 Spore germination protein GerPC; Region: GerPC; pfam10737 481743008283 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 481743008284 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 481743008285 BNR repeat-like domain; Region: BNR_2; pfam13088 481743008286 LEM3 (ligand-effect modulator 3) family / CDC50 family; Region: CDC50; cl02095 481743008287 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 481743008288 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 481743008289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743008290 NAD(P) binding site [chemical binding]; other site 481743008291 active site 481743008292 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 481743008293 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 481743008294 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 481743008295 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 481743008296 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 481743008297 sugar binding site [chemical binding]; other site 481743008298 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743008299 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743008300 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743008301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743008302 dimer interface [polypeptide binding]; other site 481743008303 conserved gate region; other site 481743008304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 481743008305 ABC-ATPase subunit interface; other site 481743008306 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743008307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743008308 dimer interface [polypeptide binding]; other site 481743008309 ABC-ATPase subunit interface; other site 481743008310 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 481743008311 CopC domain; Region: CopC; pfam04234 481743008312 Copper resistance protein D; Region: CopD; cl00563 481743008313 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743008314 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743008315 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743008316 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743008317 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 481743008318 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 481743008319 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 481743008320 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 481743008321 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 481743008322 Domain of unknown function DUF21; Region: DUF21; pfam01595 481743008323 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 481743008324 Transporter associated domain; Region: CorC_HlyC; smart01091 481743008325 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 481743008326 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 481743008327 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743008328 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743008329 DNA binding residues [nucleotide binding] 481743008330 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 481743008331 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 481743008332 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 481743008333 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 481743008334 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 481743008335 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 481743008336 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 481743008337 EamA-like transporter family; Region: EamA; pfam00892 481743008338 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 481743008339 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 481743008340 NAD binding site [chemical binding]; other site 481743008341 catalytic Zn binding site [ion binding]; other site 481743008342 structural Zn binding site [ion binding]; other site 481743008343 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 481743008344 Predicted membrane protein [Function unknown]; Region: COG4392 481743008345 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 481743008346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743008347 NAD(P) binding site [chemical binding]; other site 481743008348 active site 481743008349 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 481743008350 Sulfatase; Region: Sulfatase; pfam00884 481743008351 biotin synthase; Validated; Region: PRK06256 481743008352 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743008353 FeS/SAM binding site; other site 481743008354 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 481743008355 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 481743008356 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 481743008357 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 481743008358 DHH family; Region: DHH; pfam01368 481743008359 DHHA1 domain; Region: DHHA1; pfam02272 481743008360 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 481743008361 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 481743008362 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 481743008363 Subunit I/III interface [polypeptide binding]; other site 481743008364 Subunit III/IV interface [polypeptide binding]; other site 481743008365 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 481743008366 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 481743008367 D-pathway; other site 481743008368 Putative ubiquinol binding site [chemical binding]; other site 481743008369 Low-spin heme (heme b) binding site [chemical binding]; other site 481743008370 Putative water exit pathway; other site 481743008371 Binuclear center (heme o3/CuB) [ion binding]; other site 481743008372 K-pathway; other site 481743008373 Putative proton exit pathway; other site 481743008374 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 481743008375 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 481743008376 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 481743008377 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743008378 DNA-binding site [nucleotide binding]; DNA binding site 481743008379 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743008380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743008381 homodimer interface [polypeptide binding]; other site 481743008382 catalytic residue [active] 481743008383 Lysine efflux permease [General function prediction only]; Region: COG1279 481743008384 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 481743008385 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 481743008386 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743008387 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743008388 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 481743008389 Walker A/P-loop; other site 481743008390 ATP binding site [chemical binding]; other site 481743008391 Q-loop/lid; other site 481743008392 ABC transporter signature motif; other site 481743008393 Walker B; other site 481743008394 D-loop; other site 481743008395 H-loop/switch region; other site 481743008396 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743008397 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743008398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743008399 Walker A/P-loop; other site 481743008400 ATP binding site [chemical binding]; other site 481743008401 Q-loop/lid; other site 481743008402 ABC transporter signature motif; other site 481743008403 Walker B; other site 481743008404 D-loop; other site 481743008405 H-loop/switch region; other site 481743008406 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 481743008407 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 481743008408 VanZ like family; Region: VanZ; pfam04892 481743008409 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 481743008410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743008411 putative substrate translocation pore; other site 481743008412 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 481743008413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481743008414 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 481743008415 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 481743008416 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 481743008417 [4Fe-4S] binding site [ion binding]; other site 481743008418 molybdopterin cofactor binding site; other site 481743008419 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 481743008420 molybdopterin cofactor binding site; other site 481743008421 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 481743008422 nucleotide binding site/active site [active] 481743008423 HIT family signature motif; other site 481743008424 catalytic residue [active] 481743008425 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 481743008426 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 481743008427 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743008428 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743008429 DNA binding residues [nucleotide binding] 481743008430 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 481743008431 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743008432 Phosphotransferase enzyme family; Region: APH; pfam01636 481743008433 active site 481743008434 substrate binding site [chemical binding]; other site 481743008435 ATP binding site [chemical binding]; other site 481743008436 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 481743008437 Phosphotransferase enzyme family; Region: APH; pfam01636 481743008438 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 481743008439 active site 481743008440 ATP binding site [chemical binding]; other site 481743008441 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743008442 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 481743008443 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 481743008444 Mg++ binding site [ion binding]; other site 481743008445 putative catalytic motif [active] 481743008446 putative substrate binding site [chemical binding]; other site 481743008447 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 481743008448 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 481743008449 topology modulation protein; Reviewed; Region: PRK08118 481743008450 AAA domain; Region: AAA_17; pfam13207 481743008451 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743008452 Coenzyme A binding pocket [chemical binding]; other site 481743008453 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743008454 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 481743008455 Coenzyme A binding pocket [chemical binding]; other site 481743008456 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 481743008457 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 481743008458 nudix motif; other site 481743008459 hypothetical protein; Provisional; Region: PRK06762 481743008460 AAA domain; Region: AAA_33; pfam13671 481743008461 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 481743008462 AAA domain; Region: AAA_18; pfam13238 481743008463 P-loop motif; other site 481743008464 ATP binding site [chemical binding]; other site 481743008465 Chloramphenicol (Cm) binding site [chemical binding]; other site 481743008466 catalytic residue [active] 481743008467 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 481743008468 putative acetyltransferase; Provisional; Region: PRK03624 481743008469 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743008470 Coenzyme A binding pocket [chemical binding]; other site 481743008471 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 481743008472 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 481743008473 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 481743008474 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 481743008475 putative dimer interface [polypeptide binding]; other site 481743008476 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743008477 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 481743008478 nudix motif; other site 481743008479 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 481743008480 Phosphotransferase enzyme family; Region: APH; pfam01636 481743008481 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 481743008482 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 481743008483 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 481743008484 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 481743008485 G1 box; other site 481743008486 putative GEF interaction site [polypeptide binding]; other site 481743008487 GTP/Mg2+ binding site [chemical binding]; other site 481743008488 Switch I region; other site 481743008489 G2 box; other site 481743008490 G3 box; other site 481743008491 Switch II region; other site 481743008492 G4 box; other site 481743008493 G5 box; other site 481743008494 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 481743008495 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 481743008496 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 481743008497 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 481743008498 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 481743008499 Coenzyme A binding pocket [chemical binding]; other site 481743008500 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 481743008501 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 481743008502 active site 481743008503 metal binding site [ion binding]; metal-binding site 481743008504 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 481743008505 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 481743008506 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 481743008507 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 481743008508 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 481743008509 active site 481743008510 HIGH motif; other site 481743008511 nucleotide binding site [chemical binding]; other site 481743008512 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 481743008513 active site 481743008514 KMSKS motif; other site 481743008515 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 481743008516 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 481743008517 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 481743008518 Protein of unknown function, DUF606; Region: DUF606; pfam04657 481743008519 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 481743008520 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 481743008521 ligand binding site [chemical binding]; other site 481743008522 flexible hinge region; other site 481743008523 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 481743008524 Protein of unknown function, DUF606; Region: DUF606; pfam04657 481743008525 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 481743008526 nudix motif; other site 481743008527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743008528 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743008529 putative substrate translocation pore; other site 481743008530 Predicted membrane protein [Function unknown]; Region: COG4270 481743008531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743008532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743008533 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 481743008534 KWG Leptospira; Region: KWG; pfam07656 481743008535 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 481743008536 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 481743008537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743008538 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743008539 putative substrate translocation pore; other site 481743008540 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743008541 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743008542 DNA binding site [nucleotide binding] 481743008543 domain linker motif; other site 481743008544 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 481743008545 dimerization interface [polypeptide binding]; other site 481743008546 ligand binding site [chemical binding]; other site 481743008547 sodium binding site [ion binding]; other site 481743008548 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743008549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743008550 dimer interface [polypeptide binding]; other site 481743008551 conserved gate region; other site 481743008552 putative PBP binding loops; other site 481743008553 ABC-ATPase subunit interface; other site 481743008554 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743008555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 481743008556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743008557 dimer interface [polypeptide binding]; other site 481743008558 conserved gate region; other site 481743008559 putative PBP binding loops; other site 481743008560 ABC-ATPase subunit interface; other site 481743008561 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743008562 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743008563 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 481743008564 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 481743008565 putative substrate binding site [chemical binding]; other site 481743008566 putative ATP binding site [chemical binding]; other site 481743008567 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 481743008568 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 481743008569 substrate binding [chemical binding]; other site 481743008570 active site 481743008571 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 481743008572 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 481743008573 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 481743008574 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 481743008575 substrate binding [chemical binding]; other site 481743008576 active site 481743008577 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 481743008578 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 481743008579 active site 481743008580 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 481743008581 Phosphotransferase enzyme family; Region: APH; pfam01636 481743008582 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743008583 active site 481743008584 substrate binding site [chemical binding]; other site 481743008585 ATP binding site [chemical binding]; other site 481743008586 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743008587 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743008588 DNA binding site [nucleotide binding] 481743008589 domain linker motif; other site 481743008590 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743008591 dimerization interface [polypeptide binding]; other site 481743008592 ligand binding site [chemical binding]; other site 481743008593 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 481743008594 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743008595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743008596 dimer interface [polypeptide binding]; other site 481743008597 conserved gate region; other site 481743008598 ABC-ATPase subunit interface; other site 481743008599 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743008600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743008601 dimer interface [polypeptide binding]; other site 481743008602 conserved gate region; other site 481743008603 putative PBP binding loops; other site 481743008604 ABC-ATPase subunit interface; other site 481743008605 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743008606 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743008607 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 481743008608 active site 481743008609 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 481743008610 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 481743008611 nucleotide binding site [chemical binding]; other site 481743008612 Response regulator receiver domain; Region: Response_reg; pfam00072 481743008613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743008614 active site 481743008615 phosphorylation site [posttranslational modification] 481743008616 intermolecular recognition site; other site 481743008617 dimerization interface [polypeptide binding]; other site 481743008618 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743008619 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743008620 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743008621 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743008622 dimerization interface [polypeptide binding]; other site 481743008623 Histidine kinase; Region: His_kinase; pfam06580 481743008624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743008625 ATP binding site [chemical binding]; other site 481743008626 Mg2+ binding site [ion binding]; other site 481743008627 G-X-G motif; other site 481743008628 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743008629 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743008630 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743008631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 481743008632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743008633 dimer interface [polypeptide binding]; other site 481743008634 conserved gate region; other site 481743008635 putative PBP binding loops; other site 481743008636 ABC-ATPase subunit interface; other site 481743008637 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743008638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743008639 dimer interface [polypeptide binding]; other site 481743008640 conserved gate region; other site 481743008641 putative PBP binding loops; other site 481743008642 ABC-ATPase subunit interface; other site 481743008643 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 481743008644 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 481743008645 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 481743008646 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 481743008647 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743008648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743008649 homodimer interface [polypeptide binding]; other site 481743008650 catalytic residue [active] 481743008651 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 481743008652 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 481743008653 Spore germination protein; Region: Spore_permease; cl17796 481743008654 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 481743008655 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 481743008656 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 481743008657 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743008658 DNA-binding site [nucleotide binding]; DNA binding site 481743008659 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743008660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743008661 homodimer interface [polypeptide binding]; other site 481743008662 catalytic residue [active] 481743008663 EamA-like transporter family; Region: EamA; cl17759 481743008664 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 481743008665 EamA-like transporter family; Region: EamA; pfam00892 481743008666 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 481743008667 Mn-containing catalase [Inorganic ion transport and metabolism]; Region: COG3546 481743008668 dinuclear metal binding motif [ion binding]; other site 481743008669 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743008670 active site 481743008671 substrate binding site [chemical binding]; other site 481743008672 Phosphotransferase enzyme family; Region: APH; pfam01636 481743008673 ATP binding site [chemical binding]; other site 481743008674 Predicted acetyltransferase [General function prediction only]; Region: COG5628 481743008675 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 481743008676 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743008677 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743008678 DNA binding residues [nucleotide binding] 481743008679 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 481743008680 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 481743008681 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 481743008682 ANTAR domain; Region: ANTAR; pfam03861 481743008683 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 481743008684 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481743008685 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 481743008686 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 481743008687 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 481743008688 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 481743008689 [2Fe-2S] cluster binding site [ion binding]; other site 481743008690 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 481743008691 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 481743008692 active site 481743008693 SAM binding site [chemical binding]; other site 481743008694 homodimer interface [polypeptide binding]; other site 481743008695 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 481743008696 FAD binding domain; Region: FAD_binding_2; pfam00890 481743008697 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481743008698 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481743008699 active site 481743008700 catalytic tetrad [active] 481743008701 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 481743008702 active site 481743008703 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 481743008704 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 481743008705 active site 481743008706 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 481743008707 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 481743008708 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743008709 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743008710 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 481743008711 Walker A/P-loop; other site 481743008712 ATP binding site [chemical binding]; other site 481743008713 Q-loop/lid; other site 481743008714 ABC transporter signature motif; other site 481743008715 Walker B; other site 481743008716 D-loop; other site 481743008717 H-loop/switch region; other site 481743008718 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 481743008719 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 481743008720 EamA-like transporter family; Region: EamA; pfam00892 481743008721 EamA-like transporter family; Region: EamA; pfam00892 481743008722 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743008723 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743008724 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 481743008725 dimerization interface [polypeptide binding]; other site 481743008726 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 481743008727 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743008728 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 481743008729 DNA binding residues [nucleotide binding] 481743008730 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 481743008731 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 481743008732 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743008733 dimerization interface [polypeptide binding]; other site 481743008734 putative DNA binding site [nucleotide binding]; other site 481743008735 putative Zn2+ binding site [ion binding]; other site 481743008736 Predicted flavoprotein [General function prediction only]; Region: COG0431 481743008737 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 481743008738 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 481743008739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743008740 Coenzyme A binding pocket [chemical binding]; other site 481743008741 Predicted membrane protein [Function unknown]; Region: COG2323 481743008742 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 481743008743 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 481743008744 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 481743008745 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 481743008746 active site 481743008747 dimer interface [polypeptide binding]; other site 481743008748 motif 1; other site 481743008749 motif 2; other site 481743008750 motif 3; other site 481743008751 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 481743008752 anticodon binding site; other site 481743008753 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 481743008754 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 481743008755 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 481743008756 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743008757 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743008758 dimerization interface [polypeptide binding]; other site 481743008759 Histidine kinase; Region: His_kinase; pfam06580 481743008760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743008761 ATP binding site [chemical binding]; other site 481743008762 Mg2+ binding site [ion binding]; other site 481743008763 G-X-G motif; other site 481743008764 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 481743008765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743008766 active site 481743008767 phosphorylation site [posttranslational modification] 481743008768 intermolecular recognition site; other site 481743008769 dimerization interface [polypeptide binding]; other site 481743008770 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743008771 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743008772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743008773 dimer interface [polypeptide binding]; other site 481743008774 ABC-ATPase subunit interface; other site 481743008775 putative PBP binding loops; other site 481743008776 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743008777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743008778 dimer interface [polypeptide binding]; other site 481743008779 conserved gate region; other site 481743008780 putative PBP binding loops; other site 481743008781 ABC-ATPase subunit interface; other site 481743008782 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743008783 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743008784 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 481743008785 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 481743008786 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 481743008787 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 481743008788 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 481743008789 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 481743008790 Spore germination protein; Region: Spore_permease; cl17796 481743008791 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 481743008792 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 481743008793 DNA binding residues [nucleotide binding] 481743008794 dimer interface [polypeptide binding]; other site 481743008795 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 481743008796 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 481743008797 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 481743008798 heme binding pocket [chemical binding]; other site 481743008799 heme ligand [chemical binding]; other site 481743008800 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 481743008801 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 481743008802 THF binding site; other site 481743008803 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 481743008804 substrate binding site [chemical binding]; other site 481743008805 THF binding site; other site 481743008806 zinc-binding site [ion binding]; other site 481743008807 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 481743008808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743008809 S-adenosylmethionine binding site [chemical binding]; other site 481743008810 DNA methylase; Region: N6_N4_Mtase; cl17433 481743008811 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481743008812 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481743008813 metal binding site [ion binding]; metal-binding site 481743008814 active site 481743008815 I-site; other site 481743008816 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 481743008817 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 481743008818 catalytic residues [active] 481743008819 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 481743008820 dimerization interface [polypeptide binding]; other site 481743008821 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 481743008822 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 481743008823 dimer interface [polypeptide binding]; other site 481743008824 putative CheW interface [polypeptide binding]; other site 481743008825 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 481743008826 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 481743008827 acyl-activating enzyme (AAE) consensus motif; other site 481743008828 AMP binding site [chemical binding]; other site 481743008829 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 481743008830 thioester reductase domain; Region: Thioester-redct; TIGR01746 481743008831 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 481743008832 putative NAD(P) binding site [chemical binding]; other site 481743008833 active site 481743008834 putative substrate binding site [chemical binding]; other site 481743008835 glutaminase A; Region: Gln_ase; TIGR03814 481743008836 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 481743008837 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 481743008838 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 481743008839 YugN-like family; Region: YugN; pfam08868 481743008840 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 481743008841 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 481743008842 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 481743008843 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 481743008844 metal binding site [ion binding]; metal-binding site 481743008845 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 481743008846 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 481743008847 nucleophilic elbow; other site 481743008848 catalytic triad; other site 481743008849 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 481743008850 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 481743008851 substrate binding pocket [chemical binding]; other site 481743008852 chain length determination region; other site 481743008853 substrate-Mg2+ binding site; other site 481743008854 catalytic residues [active] 481743008855 aspartate-rich region 1; other site 481743008856 active site lid residues [active] 481743008857 aspartate-rich region 2; other site 481743008858 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 481743008859 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 481743008860 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743008861 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743008862 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 481743008863 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 481743008864 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743008865 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 481743008866 active site 481743008867 metal binding site [ion binding]; metal-binding site 481743008868 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 481743008869 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 481743008870 active site 481743008871 catalytic residues [active] 481743008872 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 481743008873 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 481743008874 putative sugar binding sites [chemical binding]; other site 481743008875 Q-X-W motif; other site 481743008876 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 481743008877 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 481743008878 active site 481743008879 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 481743008880 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 481743008881 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 481743008882 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 481743008883 Catalytic domain of Protein Kinases; Region: PKc; cd00180 481743008884 active site 481743008885 ATP binding site [chemical binding]; other site 481743008886 substrate binding site [chemical binding]; other site 481743008887 activation loop (A-loop); other site 481743008888 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 481743008889 Helix-turn-helix domain; Region: HTH_18; pfam12833 481743008890 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743008891 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 481743008892 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 481743008893 protein binding surface [polypeptide binding]; other site 481743008894 HEAT repeats; Region: HEAT_2; pfam13646 481743008895 N-terminal catalytic domain of mainly uncharacterized eukaryotic proteins similar to alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like_1; cd10791 481743008896 putative active site [active] 481743008897 catalytic site [active] 481743008898 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 481743008899 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 481743008900 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 481743008901 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 481743008902 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743008903 Phosphotransferase enzyme family; Region: APH; pfam01636 481743008904 active site 481743008905 ATP binding site [chemical binding]; other site 481743008906 Methyltransferase domain; Region: Methyltransf_31; pfam13847 481743008907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743008908 S-adenosylmethionine binding site [chemical binding]; other site 481743008909 putative deaminase; Validated; Region: PRK06846 481743008910 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 481743008911 active site 481743008912 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743008913 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743008914 dimerization interface [polypeptide binding]; other site 481743008915 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743008916 dimer interface [polypeptide binding]; other site 481743008917 phosphorylation site [posttranslational modification] 481743008918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743008919 ATP binding site [chemical binding]; other site 481743008920 Mg2+ binding site [ion binding]; other site 481743008921 G-X-G motif; other site 481743008922 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743008923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743008924 active site 481743008925 phosphorylation site [posttranslational modification] 481743008926 intermolecular recognition site; other site 481743008927 dimerization interface [polypeptide binding]; other site 481743008928 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743008929 DNA binding site [nucleotide binding] 481743008930 S-layer homology domain; Region: SLH; pfam00395 481743008931 S-layer homology domain; Region: SLH; pfam00395 481743008932 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 481743008933 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 481743008934 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 481743008935 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 481743008936 Ca binding site [ion binding]; other site 481743008937 active site 481743008938 catalytic site [active] 481743008939 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 481743008940 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 481743008941 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 481743008942 active site turn [active] 481743008943 phosphorylation site [posttranslational modification] 481743008944 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 481743008945 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 481743008946 HPr interaction site; other site 481743008947 glycerol kinase (GK) interaction site [polypeptide binding]; other site 481743008948 active site 481743008949 phosphorylation site [posttranslational modification] 481743008950 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 481743008951 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743008952 DNA-binding site [nucleotide binding]; DNA binding site 481743008953 UTRA domain; Region: UTRA; pfam07702 481743008954 short chain dehydrogenase; Provisional; Region: PRK07062 481743008955 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 481743008956 putative NAD(P) binding site [chemical binding]; other site 481743008957 putative active site [active] 481743008958 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743008959 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743008960 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743008961 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 481743008962 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 481743008963 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 481743008964 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 481743008965 Spore germination protein; Region: Spore_permease; cl17796 481743008966 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 481743008967 RibD C-terminal domain; Region: RibD_C; cl17279 481743008968 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 481743008969 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 481743008970 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743008971 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743008972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743008973 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 481743008974 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743008975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743008976 dimer interface [polypeptide binding]; other site 481743008977 conserved gate region; other site 481743008978 ABC-ATPase subunit interface; other site 481743008979 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743008980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743008981 dimer interface [polypeptide binding]; other site 481743008982 conserved gate region; other site 481743008983 ABC-ATPase subunit interface; other site 481743008984 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743008985 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743008986 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 481743008987 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743008988 DNA-binding site [nucleotide binding]; DNA binding site 481743008989 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743008990 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743008991 dimerization interface [polypeptide binding]; other site 481743008992 ligand binding site [chemical binding]; other site 481743008993 AAA domain; Region: AAA_33; pfam13671 481743008994 AAA domain; Region: AAA_17; pfam13207 481743008995 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 481743008996 RNA ligase; Region: RNA_ligase; pfam09414 481743008997 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 481743008998 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 481743008999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743009000 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743009001 dimerization interface [polypeptide binding]; other site 481743009002 Histidine kinase; Region: His_kinase; pfam06580 481743009003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743009004 ATP binding site [chemical binding]; other site 481743009005 Mg2+ binding site [ion binding]; other site 481743009006 G-X-G motif; other site 481743009007 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 481743009008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743009009 active site 481743009010 phosphorylation site [posttranslational modification] 481743009011 intermolecular recognition site; other site 481743009012 dimerization interface [polypeptide binding]; other site 481743009013 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009014 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009015 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743009016 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743009017 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743009018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009019 dimer interface [polypeptide binding]; other site 481743009020 conserved gate region; other site 481743009021 putative PBP binding loops; other site 481743009022 ABC-ATPase subunit interface; other site 481743009023 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743009024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009025 dimer interface [polypeptide binding]; other site 481743009026 conserved gate region; other site 481743009027 putative PBP binding loops; other site 481743009028 ABC-ATPase subunit interface; other site 481743009029 Domain of unknown function (DUF377); Region: DUF377; pfam04041 481743009030 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 481743009031 active site 481743009032 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 481743009033 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 481743009034 sugar binding site [chemical binding]; other site 481743009035 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743009036 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743009037 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009038 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 481743009039 HAMP domain; Region: HAMP; pfam00672 481743009040 dimerization interface [polypeptide binding]; other site 481743009041 Histidine kinase; Region: His_kinase; pfam06580 481743009042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743009043 ATP binding site [chemical binding]; other site 481743009044 Mg2+ binding site [ion binding]; other site 481743009045 G-X-G motif; other site 481743009046 Response regulator receiver domain; Region: Response_reg; pfam00072 481743009047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743009048 active site 481743009049 phosphorylation site [posttranslational modification] 481743009050 intermolecular recognition site; other site 481743009051 dimerization interface [polypeptide binding]; other site 481743009052 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009053 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743009054 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009055 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743009056 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743009057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009058 dimer interface [polypeptide binding]; other site 481743009059 conserved gate region; other site 481743009060 ABC-ATPase subunit interface; other site 481743009061 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743009062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009063 dimer interface [polypeptide binding]; other site 481743009064 conserved gate region; other site 481743009065 putative PBP binding loops; other site 481743009066 ABC-ATPase subunit interface; other site 481743009067 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743009068 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743009069 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743009070 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 481743009071 active site 481743009072 Methyltransferase domain; Region: Methyltransf_31; pfam13847 481743009073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743009074 S-adenosylmethionine binding site [chemical binding]; other site 481743009075 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 481743009076 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 481743009077 DinB superfamily; Region: DinB_2; pfam12867 481743009078 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 481743009079 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 481743009080 putative active site [active] 481743009081 putative metal binding site [ion binding]; other site 481743009082 OsmC-like protein; Region: OsmC; pfam02566 481743009083 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 481743009084 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 481743009085 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 481743009086 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481743009087 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481743009088 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743009089 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743009090 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 481743009091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743009092 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743009093 putative substrate translocation pore; other site 481743009094 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743009095 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 481743009096 hydroxyglutarate oxidase; Provisional; Region: PRK11728 481743009097 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 481743009098 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743009099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743009100 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 481743009101 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 481743009102 Coenzyme A binding pocket [chemical binding]; other site 481743009103 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 481743009104 Cytochrome P450; Region: p450; pfam00067 481743009105 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 481743009106 Flavodoxin; Region: Flavodoxin_1; pfam00258 481743009107 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 481743009108 FAD binding pocket [chemical binding]; other site 481743009109 FAD binding motif [chemical binding]; other site 481743009110 catalytic residues [active] 481743009111 NAD binding pocket [chemical binding]; other site 481743009112 phosphate binding motif [ion binding]; other site 481743009113 beta-alpha-beta structure motif; other site 481743009114 Predicted transcriptional regulators [Transcription]; Region: COG1733 481743009115 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 481743009116 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 481743009117 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 481743009118 ZIP Zinc transporter; Region: Zip; pfam02535 481743009119 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 481743009120 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 481743009121 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 481743009122 Phosphotransferase enzyme family; Region: APH; pfam01636 481743009123 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 481743009124 active site 481743009125 substrate binding site [chemical binding]; other site 481743009126 ATP binding site [chemical binding]; other site 481743009127 Beta-lactamase; Region: Beta-lactamase; pfam00144 481743009128 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 481743009129 S-layer homology domain; Region: SLH; pfam00395 481743009130 S-layer homology domain; Region: SLH; pfam00395 481743009131 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 481743009132 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 481743009133 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 481743009134 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 481743009135 DNA binding residues [nucleotide binding] 481743009136 drug binding residues [chemical binding]; other site 481743009137 dimer interface [polypeptide binding]; other site 481743009138 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 481743009139 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 481743009140 Beta-lactamase; Region: Beta-lactamase; pfam00144 481743009141 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 481743009142 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 481743009143 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 481743009144 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 481743009145 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743009146 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009147 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743009148 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009149 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743009150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009151 ABC-ATPase subunit interface; other site 481743009152 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743009153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009154 ABC-ATPase subunit interface; other site 481743009155 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743009156 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 481743009157 Right handed beta helix region; Region: Beta_helix; pfam13229 481743009158 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 481743009159 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 481743009160 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 481743009161 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 481743009162 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 481743009163 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 481743009164 Cytochrome P450; Region: p450; cl12078 481743009165 Predicted transcriptional regulators [Transcription]; Region: COG1695 481743009166 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 481743009167 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 481743009168 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 481743009169 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 481743009170 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 481743009171 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743009172 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743009173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009174 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 481743009175 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 481743009176 intersubunit interface [polypeptide binding]; other site 481743009177 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 481743009178 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 481743009179 intersubunit interface [polypeptide binding]; other site 481743009180 malate:quinone oxidoreductase; Validated; Region: PRK05257 481743009181 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 481743009182 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009183 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743009184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009185 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 481743009186 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 481743009187 intersubunit interface [polypeptide binding]; other site 481743009188 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 481743009189 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 481743009190 siderophore binding site; other site 481743009191 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 481743009192 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481743009193 ABC-ATPase subunit interface; other site 481743009194 dimer interface [polypeptide binding]; other site 481743009195 putative PBP binding regions; other site 481743009196 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 481743009197 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481743009198 ABC-ATPase subunit interface; other site 481743009199 dimer interface [polypeptide binding]; other site 481743009200 putative PBP binding regions; other site 481743009201 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 481743009202 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 481743009203 Walker A/P-loop; other site 481743009204 ATP binding site [chemical binding]; other site 481743009205 Q-loop/lid; other site 481743009206 ABC transporter signature motif; other site 481743009207 Walker B; other site 481743009208 D-loop; other site 481743009209 H-loop/switch region; other site 481743009210 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 481743009211 Domain of unknown function (DUF377); Region: DUF377; pfam04041 481743009212 Glycosyl hydrolase family 43 containing a domain of unknown function; Region: GH43_DUF377; cd08993 481743009213 active site 481743009214 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743009215 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743009216 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743009217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009218 putative PBP binding loops; other site 481743009219 ABC-ATPase subunit interface; other site 481743009220 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743009221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009222 dimer interface [polypeptide binding]; other site 481743009223 conserved gate region; other site 481743009224 ABC-ATPase subunit interface; other site 481743009225 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743009226 dimerization interface [polypeptide binding]; other site 481743009227 Histidine kinase; Region: His_kinase; pfam06580 481743009228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743009229 ATP binding site [chemical binding]; other site 481743009230 Mg2+ binding site [ion binding]; other site 481743009231 G-X-G motif; other site 481743009232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743009233 Response regulator receiver domain; Region: Response_reg; pfam00072 481743009234 active site 481743009235 phosphorylation site [posttranslational modification] 481743009236 intermolecular recognition site; other site 481743009237 dimerization interface [polypeptide binding]; other site 481743009238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009239 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743009240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009241 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 481743009242 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 481743009243 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 481743009244 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743009245 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743009246 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 481743009247 putative catalytic site [active] 481743009248 putative metal binding site [ion binding]; other site 481743009249 putative phosphate binding site [ion binding]; other site 481743009250 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 481743009251 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 481743009252 Spore germination protein; Region: Spore_permease; cl17796 481743009253 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 481743009254 Transcriptional regulators [Transcription]; Region: FadR; COG2186 481743009255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743009256 DNA-binding site [nucleotide binding]; DNA binding site 481743009257 FCD domain; Region: FCD; pfam07729 481743009258 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 481743009259 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743009260 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009261 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743009262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009263 dimer interface [polypeptide binding]; other site 481743009264 conserved gate region; other site 481743009265 ABC-ATPase subunit interface; other site 481743009266 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743009267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009268 dimer interface [polypeptide binding]; other site 481743009269 conserved gate region; other site 481743009270 putative PBP binding loops; other site 481743009271 ABC-ATPase subunit interface; other site 481743009272 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743009273 Beta-lactamase; Region: Beta-lactamase; pfam00144 481743009274 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 481743009275 putative pectinesterase; Region: PLN02432; cl01911 481743009276 Pectinesterase; Region: Pectinesterase; pfam01095 481743009277 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 481743009278 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 481743009279 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 481743009280 active site 481743009281 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743009282 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009283 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743009284 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009285 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 481743009286 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 481743009287 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 481743009288 Pectate lyase; Region: Pec_lyase_C; cl01593 481743009289 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 481743009290 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 481743009291 Hemerythrin-like domain; Region: Hr-like; cd12108 481743009292 Fe binding site [ion binding]; other site 481743009293 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 481743009294 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 481743009295 dimer interface [polypeptide binding]; other site 481743009296 putative CheW interface [polypeptide binding]; other site 481743009297 Predicted membrane protein [Function unknown]; Region: COG2323 481743009298 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 481743009299 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 481743009300 PsbP; Region: PsbP; cl03356 481743009301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 481743009302 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 481743009303 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 481743009304 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 481743009305 substrate binding site [chemical binding]; other site 481743009306 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 481743009307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009308 dimer interface [polypeptide binding]; other site 481743009309 conserved gate region; other site 481743009310 putative PBP binding loops; other site 481743009311 ABC-ATPase subunit interface; other site 481743009312 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 481743009313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009314 dimer interface [polypeptide binding]; other site 481743009315 conserved gate region; other site 481743009316 putative PBP binding loops; other site 481743009317 ABC-ATPase subunit interface; other site 481743009318 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743009319 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 481743009320 Walker A/P-loop; other site 481743009321 ATP binding site [chemical binding]; other site 481743009322 Q-loop/lid; other site 481743009323 ABC transporter signature motif; other site 481743009324 Walker B; other site 481743009325 D-loop; other site 481743009326 H-loop/switch region; other site 481743009327 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 481743009328 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743009329 Walker A/P-loop; other site 481743009330 ATP binding site [chemical binding]; other site 481743009331 Q-loop/lid; other site 481743009332 ABC transporter signature motif; other site 481743009333 Walker B; other site 481743009334 D-loop; other site 481743009335 H-loop/switch region; other site 481743009336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743009337 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743009338 putative substrate translocation pore; other site 481743009339 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 481743009340 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 481743009341 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 481743009342 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743009343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743009344 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743009345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743009346 active site 481743009347 phosphorylation site [posttranslational modification] 481743009348 intermolecular recognition site; other site 481743009349 dimerization interface [polypeptide binding]; other site 481743009350 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743009351 DNA binding site [nucleotide binding] 481743009352 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743009353 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743009354 dimerization interface [polypeptide binding]; other site 481743009355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743009356 dimer interface [polypeptide binding]; other site 481743009357 phosphorylation site [posttranslational modification] 481743009358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743009359 ATP binding site [chemical binding]; other site 481743009360 Mg2+ binding site [ion binding]; other site 481743009361 G-X-G motif; other site 481743009362 Acyltransferase family; Region: Acyl_transf_3; pfam01757 481743009363 MASE1; Region: MASE1; cl17823 481743009364 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 481743009365 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743009366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743009367 ATP binding site [chemical binding]; other site 481743009368 Mg2+ binding site [ion binding]; other site 481743009369 G-X-G motif; other site 481743009370 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743009371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743009372 active site 481743009373 phosphorylation site [posttranslational modification] 481743009374 intermolecular recognition site; other site 481743009375 dimerization interface [polypeptide binding]; other site 481743009376 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743009377 DNA binding site [nucleotide binding] 481743009378 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 481743009379 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 481743009380 Walker A/P-loop; other site 481743009381 ATP binding site [chemical binding]; other site 481743009382 Q-loop/lid; other site 481743009383 ABC transporter signature motif; other site 481743009384 Walker B; other site 481743009385 D-loop; other site 481743009386 H-loop/switch region; other site 481743009387 FtsX-like permease family; Region: FtsX; pfam02687 481743009388 FtsX-like permease family; Region: FtsX; pfam02687 481743009389 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 481743009390 intersubunit interface [polypeptide binding]; other site 481743009391 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 481743009392 active site 481743009393 Zn2+ binding site [ion binding]; other site 481743009394 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 481743009395 intersubunit interface [polypeptide binding]; other site 481743009396 active site 481743009397 Zn2+ binding site [ion binding]; other site 481743009398 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743009399 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743009400 DNA binding site [nucleotide binding] 481743009401 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743009402 ligand binding site [chemical binding]; other site 481743009403 dimerization interface [polypeptide binding]; other site 481743009404 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743009405 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743009406 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743009407 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743009408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009409 dimer interface [polypeptide binding]; other site 481743009410 conserved gate region; other site 481743009411 putative PBP binding loops; other site 481743009412 ABC-ATPase subunit interface; other site 481743009413 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743009414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009415 dimer interface [polypeptide binding]; other site 481743009416 conserved gate region; other site 481743009417 ABC-ATPase subunit interface; other site 481743009418 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743009419 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743009420 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 481743009421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 481743009422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 481743009423 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 481743009424 metal ion-dependent adhesion site (MIDAS); other site 481743009425 Domain of unknown function DUF20; Region: UPF0118; pfam01594 481743009426 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 481743009427 Rrf2 family protein; Region: rrf2_super; TIGR00738 481743009428 Transcriptional regulator; Region: Rrf2; pfam02082 481743009429 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 481743009430 Protein of unknown function; Region: DUF3658; pfam12395 481743009431 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 481743009432 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 481743009433 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743009434 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743009435 DNA binding residues [nucleotide binding] 481743009436 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 481743009437 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 481743009438 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 481743009439 conserved cys residue [active] 481743009440 Predicted membrane protein [Function unknown]; Region: COG3462 481743009441 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743009442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743009443 active site 481743009444 phosphorylation site [posttranslational modification] 481743009445 intermolecular recognition site; other site 481743009446 dimerization interface [polypeptide binding]; other site 481743009447 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743009448 DNA binding site [nucleotide binding] 481743009449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743009450 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743009451 dimerization interface [polypeptide binding]; other site 481743009452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743009453 dimer interface [polypeptide binding]; other site 481743009454 phosphorylation site [posttranslational modification] 481743009455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743009456 ATP binding site [chemical binding]; other site 481743009457 Mg2+ binding site [ion binding]; other site 481743009458 G-X-G motif; other site 481743009459 Spore germination protein; Region: Spore_permease; cl17796 481743009460 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 481743009461 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 481743009462 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 481743009463 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 481743009464 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 481743009465 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 481743009466 active site 481743009467 catalytic triad [active] 481743009468 oxyanion hole [active] 481743009469 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 481743009470 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743009471 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009472 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 481743009473 classical (c) SDRs; Region: SDR_c; cd05233 481743009474 NAD(P) binding site [chemical binding]; other site 481743009475 active site 481743009476 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 481743009477 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 481743009478 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 481743009479 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 481743009480 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 481743009481 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 481743009482 Cytochrome c; Region: Cytochrom_C; pfam00034 481743009483 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 481743009484 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 481743009485 nucleophilic elbow; other site 481743009486 catalytic triad; other site 481743009487 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 481743009488 Spore germination protein; Region: Spore_permease; cl17796 481743009489 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 481743009490 Right handed beta helix region; Region: Beta_helix; pfam13229 481743009491 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 481743009492 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 481743009493 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 481743009494 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 481743009495 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 481743009496 RNA polymerase sigma factor; Provisional; Region: PRK12543 481743009497 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743009498 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743009499 DNA binding residues [nucleotide binding] 481743009500 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 481743009501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009502 dimer interface [polypeptide binding]; other site 481743009503 conserved gate region; other site 481743009504 putative PBP binding loops; other site 481743009505 ABC-ATPase subunit interface; other site 481743009506 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 481743009507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009508 dimer interface [polypeptide binding]; other site 481743009509 conserved gate region; other site 481743009510 ABC-ATPase subunit interface; other site 481743009511 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 481743009512 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 481743009513 Walker A/P-loop; other site 481743009514 ATP binding site [chemical binding]; other site 481743009515 Q-loop/lid; other site 481743009516 ABC transporter signature motif; other site 481743009517 Walker B; other site 481743009518 D-loop; other site 481743009519 H-loop/switch region; other site 481743009520 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 481743009521 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481743009522 substrate binding pocket [chemical binding]; other site 481743009523 membrane-bound complex binding site; other site 481743009524 hinge residues; other site 481743009525 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 481743009526 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 481743009527 active site 481743009528 metal binding site [ion binding]; metal-binding site 481743009529 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 481743009530 DinB family; Region: DinB; cl17821 481743009531 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 481743009532 CPxP motif; other site 481743009533 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 481743009534 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 481743009535 active site 481743009536 DNA binding site [nucleotide binding] 481743009537 Int/Topo IB signature motif; other site 481743009538 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 481743009539 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743009540 Coenzyme A binding pocket [chemical binding]; other site 481743009541 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743009542 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 481743009543 active site 481743009544 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 481743009545 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743009546 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 481743009547 Coenzyme A binding pocket [chemical binding]; other site 481743009548 AAA domain; Region: AAA_18; pfam13238 481743009549 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 481743009550 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 481743009551 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 481743009552 intersubunit interface [polypeptide binding]; other site 481743009553 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 481743009554 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 481743009555 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481743009556 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 481743009557 ABC-ATPase subunit interface; other site 481743009558 dimer interface [polypeptide binding]; other site 481743009559 putative PBP binding regions; other site 481743009560 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 481743009561 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481743009562 ABC-ATPase subunit interface; other site 481743009563 dimer interface [polypeptide binding]; other site 481743009564 putative PBP binding regions; other site 481743009565 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 481743009566 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743009567 Coenzyme A binding pocket [chemical binding]; other site 481743009568 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 481743009569 ADP-ribose binding site [chemical binding]; other site 481743009570 dimer interface [polypeptide binding]; other site 481743009571 active site 481743009572 nudix motif; other site 481743009573 metal binding site [ion binding]; metal-binding site 481743009574 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 481743009575 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 481743009576 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 481743009577 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 481743009578 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 481743009579 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 481743009580 active site 481743009581 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 481743009582 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 481743009583 putative homodimer interface [polypeptide binding]; other site 481743009584 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 481743009585 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 481743009586 Probable Catalytic site; other site 481743009587 metal-binding site 481743009588 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 481743009589 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 481743009590 active site 481743009591 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 481743009592 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 481743009593 Zn2+ binding site [ion binding]; other site 481743009594 Mg2+ binding site [ion binding]; other site 481743009595 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 481743009596 Protein of unknown function; Region: DUF3658; pfam12395 481743009597 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 481743009598 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 481743009599 active site 481743009600 urease subunit alpha; Reviewed; Region: ureC; PRK13207 481743009601 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 481743009602 subunit interactions [polypeptide binding]; other site 481743009603 active site 481743009604 flap region; other site 481743009605 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 481743009606 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 481743009607 alpha-gamma subunit interface [polypeptide binding]; other site 481743009608 beta-gamma subunit interface [polypeptide binding]; other site 481743009609 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 481743009610 gamma-beta subunit interface [polypeptide binding]; other site 481743009611 alpha-beta subunit interface [polypeptide binding]; other site 481743009612 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 481743009613 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 481743009614 Spore germination protein; Region: Spore_permease; cl17796 481743009615 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 481743009616 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 481743009617 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481743009618 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481743009619 metal binding site [ion binding]; metal-binding site 481743009620 active site 481743009621 I-site; other site 481743009622 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743009623 dimer interface [polypeptide binding]; other site 481743009624 phosphorylation site [posttranslational modification] 481743009625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743009626 ATP binding site [chemical binding]; other site 481743009627 Mg2+ binding site [ion binding]; other site 481743009628 G-X-G motif; other site 481743009629 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 481743009630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743009631 putative substrate translocation pore; other site 481743009632 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 481743009633 VanW like protein; Region: VanW; pfam04294 481743009634 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 481743009635 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 481743009636 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 481743009637 Cytochrome P450; Region: p450; cl12078 481743009638 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743009639 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009640 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743009641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009642 dimer interface [polypeptide binding]; other site 481743009643 conserved gate region; other site 481743009644 putative PBP binding loops; other site 481743009645 ABC-ATPase subunit interface; other site 481743009646 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743009647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009648 dimer interface [polypeptide binding]; other site 481743009649 conserved gate region; other site 481743009650 ABC-ATPase subunit interface; other site 481743009651 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743009652 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743009653 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 481743009654 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 481743009655 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 481743009656 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 481743009657 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743009658 dimer interface [polypeptide binding]; other site 481743009659 phosphorylation site [posttranslational modification] 481743009660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743009661 ATP binding site [chemical binding]; other site 481743009662 Mg2+ binding site [ion binding]; other site 481743009663 G-X-G motif; other site 481743009664 Response regulator receiver domain; Region: Response_reg; pfam00072 481743009665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743009666 active site 481743009667 phosphorylation site [posttranslational modification] 481743009668 intermolecular recognition site; other site 481743009669 dimerization interface [polypeptide binding]; other site 481743009670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 481743009671 Histidine kinase; Region: HisKA_3; pfam07730 481743009672 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743009673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743009674 active site 481743009675 phosphorylation site [posttranslational modification] 481743009676 intermolecular recognition site; other site 481743009677 dimerization interface [polypeptide binding]; other site 481743009678 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743009679 DNA binding residues [nucleotide binding] 481743009680 dimerization interface [polypeptide binding]; other site 481743009681 Rrf2 family protein; Region: rrf2_super; TIGR00738 481743009682 Transcriptional regulator; Region: Rrf2; pfam02082 481743009683 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 481743009684 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 481743009685 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 481743009686 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 481743009687 Protein phosphatase 2C; Region: PP2C_2; pfam13672 481743009688 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 481743009689 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 481743009690 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 481743009691 Spore germination protein; Region: Spore_permease; cl17796 481743009692 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 481743009693 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 481743009694 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 481743009695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743009696 DNA-binding site [nucleotide binding]; DNA binding site 481743009697 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743009698 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743009699 dimerization interface [polypeptide binding]; other site 481743009700 ligand binding site [chemical binding]; other site 481743009701 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 481743009702 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 481743009703 active site 481743009704 catalytic site [active] 481743009705 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 481743009706 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 481743009707 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743009708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009709 dimer interface [polypeptide binding]; other site 481743009710 conserved gate region; other site 481743009711 putative PBP binding loops; other site 481743009712 ABC-ATPase subunit interface; other site 481743009713 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743009714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009715 dimer interface [polypeptide binding]; other site 481743009716 conserved gate region; other site 481743009717 putative PBP binding loops; other site 481743009718 ABC-ATPase subunit interface; other site 481743009719 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743009720 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743009721 Domain of unknown function (DUF1793); Region: DUF1793; pfam08760 481743009722 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 481743009723 conserved cys residue [active] 481743009724 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 481743009725 active site 481743009726 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 481743009727 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 481743009728 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 481743009729 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743009730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009731 dimer interface [polypeptide binding]; other site 481743009732 conserved gate region; other site 481743009733 putative PBP binding loops; other site 481743009734 ABC-ATPase subunit interface; other site 481743009735 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743009736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009737 dimer interface [polypeptide binding]; other site 481743009738 conserved gate region; other site 481743009739 putative PBP binding loops; other site 481743009740 ABC-ATPase subunit interface; other site 481743009741 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743009742 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743009743 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743009744 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 481743009745 Transcriptional regulators [Transcription]; Region: MarR; COG1846 481743009746 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 481743009747 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743009748 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743009749 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 481743009750 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 481743009751 FMN binding site [chemical binding]; other site 481743009752 substrate binding site [chemical binding]; other site 481743009753 putative catalytic residue [active] 481743009754 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 481743009755 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 481743009756 Predicted transcriptional regulators [Transcription]; Region: COG1733 481743009757 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743009758 putative DNA binding site [nucleotide binding]; other site 481743009759 dimerization interface [polypeptide binding]; other site 481743009760 putative Zn2+ binding site [ion binding]; other site 481743009761 RibD C-terminal domain; Region: RibD_C; cl17279 481743009762 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 481743009763 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 481743009764 Histidine kinase; Region: HisKA_3; pfam07730 481743009765 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 481743009766 ATP binding site [chemical binding]; other site 481743009767 Mg2+ binding site [ion binding]; other site 481743009768 G-X-G motif; other site 481743009769 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743009770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743009771 active site 481743009772 phosphorylation site [posttranslational modification] 481743009773 intermolecular recognition site; other site 481743009774 dimerization interface [polypeptide binding]; other site 481743009775 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743009776 DNA binding residues [nucleotide binding] 481743009777 dimerization interface [polypeptide binding]; other site 481743009778 amidase; Provisional; Region: PRK06828 481743009779 Amidase; Region: Amidase; cl11426 481743009780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743009781 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743009782 putative substrate translocation pore; other site 481743009783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743009784 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 481743009785 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 481743009786 catalytic residues [active] 481743009787 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743009788 Coenzyme A binding pocket [chemical binding]; other site 481743009789 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743009790 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 481743009791 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 481743009792 putative active site [active] 481743009793 metal binding site [ion binding]; metal-binding site 481743009794 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 481743009795 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 481743009796 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 481743009797 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 481743009798 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 481743009799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 481743009800 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 481743009801 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 481743009802 dimer interface [polypeptide binding]; other site 481743009803 active site 481743009804 catalytic residue [active] 481743009805 metal binding site [ion binding]; metal-binding site 481743009806 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 481743009807 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743009808 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743009809 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743009810 glycerol kinase; Provisional; Region: glpK; PRK00047 481743009811 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 481743009812 N- and C-terminal domain interface [polypeptide binding]; other site 481743009813 active site 481743009814 MgATP binding site [chemical binding]; other site 481743009815 catalytic site [active] 481743009816 metal binding site [ion binding]; metal-binding site 481743009817 glycerol binding site [chemical binding]; other site 481743009818 homotetramer interface [polypeptide binding]; other site 481743009819 homodimer interface [polypeptide binding]; other site 481743009820 FBP binding site [chemical binding]; other site 481743009821 protein IIAGlc interface [polypeptide binding]; other site 481743009822 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 481743009823 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 481743009824 PYR/PP interface [polypeptide binding]; other site 481743009825 dimer interface [polypeptide binding]; other site 481743009826 TPP binding site [chemical binding]; other site 481743009827 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 481743009828 transketolase; Reviewed; Region: PRK05899 481743009829 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 481743009830 TPP-binding site [chemical binding]; other site 481743009831 dimer interface [polypeptide binding]; other site 481743009832 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 481743009833 hexamer (dimer of trimers) interface [polypeptide binding]; other site 481743009834 substrate binding site [chemical binding]; other site 481743009835 trimer interface [polypeptide binding]; other site 481743009836 Mn binding site [ion binding]; other site 481743009837 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743009838 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743009839 DNA binding site [nucleotide binding] 481743009840 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743009841 ligand binding site [chemical binding]; other site 481743009842 dimerization interface [polypeptide binding]; other site 481743009843 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 481743009844 Abhydrolase family; Region: Abhydrolase_7; pfam12715 481743009845 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 481743009846 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 481743009847 BNR repeat-like domain; Region: BNR_2; pfam13088 481743009848 catalytic site [active] 481743009849 Asp-box motif; other site 481743009850 putative pectinesterase; Region: PLN02432; cl01911 481743009851 Pectinesterase; Region: Pectinesterase; pfam01095 481743009852 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 481743009853 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 481743009854 inhibitor site; inhibition site 481743009855 active site 481743009856 dimer interface [polypeptide binding]; other site 481743009857 catalytic residue [active] 481743009858 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 481743009859 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 481743009860 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743009861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009862 dimer interface [polypeptide binding]; other site 481743009863 conserved gate region; other site 481743009864 ABC-ATPase subunit interface; other site 481743009865 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743009866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009867 ABC-ATPase subunit interface; other site 481743009868 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 481743009869 NHL repeat; Region: NHL; pfam01436 481743009870 NHL repeat; Region: NHL; pfam01436 481743009871 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 481743009872 binding surface 481743009873 Tetratricopeptide repeat; Region: TPR_16; pfam13432 481743009874 TPR motif; other site 481743009875 Yip1 domain; Region: Yip1; pfam04893 481743009876 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743009877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009878 dimer interface [polypeptide binding]; other site 481743009879 conserved gate region; other site 481743009880 ABC-ATPase subunit interface; other site 481743009881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743009882 dimer interface [polypeptide binding]; other site 481743009883 conserved gate region; other site 481743009884 ABC-ATPase subunit interface; other site 481743009885 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 481743009886 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 481743009887 putative metal binding site [ion binding]; other site 481743009888 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743009889 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743009890 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 481743009891 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 481743009892 Walker A/P-loop; other site 481743009893 ATP binding site [chemical binding]; other site 481743009894 Q-loop/lid; other site 481743009895 ABC transporter signature motif; other site 481743009896 Walker B; other site 481743009897 D-loop; other site 481743009898 H-loop/switch region; other site 481743009899 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 481743009900 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743009901 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009902 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743009903 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009904 BNR repeat-like domain; Region: BNR_2; pfam13088 481743009905 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 481743009906 catalytic site [active] 481743009907 Asp-box motif; other site 481743009908 Trehalase; Region: Trehalase; cl17346 481743009909 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743009910 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743009911 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743009912 Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917 481743009913 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 481743009914 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 481743009915 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 481743009916 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 481743009917 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 481743009918 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 481743009919 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 481743009920 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 481743009921 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 481743009922 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 481743009923 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 481743009924 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 481743009925 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 481743009926 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 481743009927 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 481743009928 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 481743009929 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 481743009930 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 481743009931 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 481743009932 Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120 481743009933 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743009934 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009935 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743009936 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009937 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743009938 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743009939 Amb_all domain; Region: Amb_all; smart00656 481743009940 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 481743009941 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743009942 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 481743009943 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743009944 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 481743009945 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 481743009946 putative NAD(P) binding site [chemical binding]; other site 481743009947 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 481743009948 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 481743009949 FMN binding site [chemical binding]; other site 481743009950 active site 481743009951 substrate binding site [chemical binding]; other site 481743009952 catalytic residue [active] 481743009953 short chain dehydrogenase; Validated; Region: PRK08264 481743009954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743009955 NAD(P) binding site [chemical binding]; other site 481743009956 active site 481743009957 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743009958 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743009959 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743009960 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743009961 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 481743009962 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743009963 Coenzyme A binding pocket [chemical binding]; other site 481743009964 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 481743009965 putative transposase OrfB; Reviewed; Region: PHA02517 481743009966 HTH-like domain; Region: HTH_21; pfam13276 481743009967 Integrase core domain; Region: rve; pfam00665 481743009968 Integrase core domain; Region: rve_3; pfam13683 481743009969 Ecdysteroid kinase; Region: EcKinase; cl17738 481743009970 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 481743009971 nudix motif; other site 481743009972 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 481743009973 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 481743009974 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743009975 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743009976 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 481743009977 dimerization interface [polypeptide binding]; other site 481743009978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743009979 putative substrate translocation pore; other site 481743009980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743009981 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 481743009982 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743009983 Phosphotransferase enzyme family; Region: APH; pfam01636 481743009984 active site 481743009985 ATP binding site [chemical binding]; other site 481743009986 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 481743009987 N-terminal domain interface [polypeptide binding]; other site 481743009988 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 481743009989 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 481743009990 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 481743009991 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 481743009992 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 481743009993 active site 481743009994 non-prolyl cis peptide bond; other site 481743009995 DinB superfamily; Region: DinB_2; pfam12867 481743009996 metal-dependent hydrolase; Provisional; Region: PRK13291 481743009997 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 481743009998 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 481743009999 metal binding site [ion binding]; metal-binding site 481743010000 dimer interface [polypeptide binding]; other site 481743010001 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 481743010002 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 481743010003 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 481743010004 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 481743010005 Walker A/P-loop; other site 481743010006 ATP binding site [chemical binding]; other site 481743010007 Q-loop/lid; other site 481743010008 ABC transporter signature motif; other site 481743010009 Walker B; other site 481743010010 D-loop; other site 481743010011 H-loop/switch region; other site 481743010012 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 481743010013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010014 dimer interface [polypeptide binding]; other site 481743010015 conserved gate region; other site 481743010016 putative PBP binding loops; other site 481743010017 ABC-ATPase subunit interface; other site 481743010018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010019 dimer interface [polypeptide binding]; other site 481743010020 conserved gate region; other site 481743010021 putative PBP binding loops; other site 481743010022 ABC-ATPase subunit interface; other site 481743010023 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 481743010024 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481743010025 substrate binding pocket [chemical binding]; other site 481743010026 membrane-bound complex binding site; other site 481743010027 hinge residues; other site 481743010028 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743010029 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743010030 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 481743010031 dimerization interface [polypeptide binding]; other site 481743010032 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 481743010033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743010034 Coenzyme A binding pocket [chemical binding]; other site 481743010035 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743010036 Coenzyme A binding pocket [chemical binding]; other site 481743010037 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 481743010038 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743010039 Walker A/P-loop; other site 481743010040 ATP binding site [chemical binding]; other site 481743010041 Q-loop/lid; other site 481743010042 ABC transporter signature motif; other site 481743010043 Walker B; other site 481743010044 D-loop; other site 481743010045 H-loop/switch region; other site 481743010046 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 481743010047 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 481743010048 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743010049 Walker A/P-loop; other site 481743010050 ATP binding site [chemical binding]; other site 481743010051 Q-loop/lid; other site 481743010052 ABC transporter signature motif; other site 481743010053 Walker B; other site 481743010054 D-loop; other site 481743010055 H-loop/switch region; other site 481743010056 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 481743010057 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 481743010058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010059 dimer interface [polypeptide binding]; other site 481743010060 conserved gate region; other site 481743010061 putative PBP binding loops; other site 481743010062 ABC-ATPase subunit interface; other site 481743010063 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 481743010064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010065 dimer interface [polypeptide binding]; other site 481743010066 conserved gate region; other site 481743010067 putative PBP binding loops; other site 481743010068 ABC-ATPase subunit interface; other site 481743010069 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 481743010070 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_11; cd08516 481743010071 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 481743010072 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743010073 motif II; other site 481743010074 Predicted acyl esterases [General function prediction only]; Region: COG2936 481743010075 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 481743010076 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 481743010077 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 481743010078 active site 481743010079 non-prolyl cis peptide bond; other site 481743010080 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 481743010081 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 481743010082 homodimer interface [polypeptide binding]; other site 481743010083 substrate-cofactor binding pocket; other site 481743010084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743010085 catalytic residue [active] 481743010086 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743010087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010088 dimer interface [polypeptide binding]; other site 481743010089 conserved gate region; other site 481743010090 putative PBP binding loops; other site 481743010091 ABC-ATPase subunit interface; other site 481743010092 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743010093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010094 dimer interface [polypeptide binding]; other site 481743010095 conserved gate region; other site 481743010096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 481743010097 ABC-ATPase subunit interface; other site 481743010098 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743010099 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743010100 Predicted transcriptional regulators [Transcription]; Region: COG1733 481743010101 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 481743010102 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 481743010103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743010104 NAD(P) binding site [chemical binding]; other site 481743010105 active site 481743010106 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743010107 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743010108 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 481743010109 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743010110 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743010111 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 481743010112 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 481743010113 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 481743010114 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 481743010115 putative NAD(P) binding site [chemical binding]; other site 481743010116 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 481743010117 short chain dehydrogenase; Provisional; Region: PRK06197 481743010118 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 481743010119 putative NAD(P) binding site [chemical binding]; other site 481743010120 active site 481743010121 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 481743010122 NADH(P)-binding; Region: NAD_binding_10; pfam13460 481743010123 NAD binding site [chemical binding]; other site 481743010124 substrate binding site [chemical binding]; other site 481743010125 putative active site [active] 481743010126 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743010127 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743010128 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743010129 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743010130 dimerization interface [polypeptide binding]; other site 481743010131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743010132 dimer interface [polypeptide binding]; other site 481743010133 phosphorylation site [posttranslational modification] 481743010134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743010135 ATP binding site [chemical binding]; other site 481743010136 Mg2+ binding site [ion binding]; other site 481743010137 G-X-G motif; other site 481743010138 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743010139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743010140 active site 481743010141 phosphorylation site [posttranslational modification] 481743010142 intermolecular recognition site; other site 481743010143 dimerization interface [polypeptide binding]; other site 481743010144 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743010145 DNA binding site [nucleotide binding] 481743010146 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 481743010147 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 481743010148 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 481743010149 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 481743010150 Domain interface; other site 481743010151 Peptide binding site; other site 481743010152 Active site tetrad [active] 481743010153 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 481743010154 RibD C-terminal domain; Region: RibD_C; cl17279 481743010155 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743010156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743010157 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 481743010158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743010159 HAMP domain; Region: HAMP; pfam00672 481743010160 Histidine kinase; Region: His_kinase; pfam06580 481743010161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743010162 ATP binding site [chemical binding]; other site 481743010163 Mg2+ binding site [ion binding]; other site 481743010164 G-X-G motif; other site 481743010165 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 481743010166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743010167 active site 481743010168 phosphorylation site [posttranslational modification] 481743010169 intermolecular recognition site; other site 481743010170 dimerization interface [polypeptide binding]; other site 481743010171 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010172 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743010173 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743010174 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743010175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010176 dimer interface [polypeptide binding]; other site 481743010177 conserved gate region; other site 481743010178 putative PBP binding loops; other site 481743010179 ABC-ATPase subunit interface; other site 481743010180 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743010181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010182 dimer interface [polypeptide binding]; other site 481743010183 conserved gate region; other site 481743010184 ABC-ATPase subunit interface; other site 481743010185 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743010186 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743010187 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 481743010188 Protein of unknown function (DUF993); Region: DUF993; pfam06187 481743010189 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743010190 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743010191 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743010192 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743010193 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010194 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743010195 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743010196 dimerization interface [polypeptide binding]; other site 481743010197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743010198 dimer interface [polypeptide binding]; other site 481743010199 phosphorylation site [posttranslational modification] 481743010200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743010201 ATP binding site [chemical binding]; other site 481743010202 Mg2+ binding site [ion binding]; other site 481743010203 G-X-G motif; other site 481743010204 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743010205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743010206 active site 481743010207 phosphorylation site [posttranslational modification] 481743010208 intermolecular recognition site; other site 481743010209 dimerization interface [polypeptide binding]; other site 481743010210 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743010211 DNA binding site [nucleotide binding] 481743010212 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 481743010213 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 481743010214 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 481743010215 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 481743010216 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 481743010217 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 481743010218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 481743010219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 481743010220 Putative glucoamylase; Region: Glycoamylase; pfam10091 481743010221 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743010222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010223 dimer interface [polypeptide binding]; other site 481743010224 conserved gate region; other site 481743010225 putative PBP binding loops; other site 481743010226 ABC-ATPase subunit interface; other site 481743010227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010228 dimer interface [polypeptide binding]; other site 481743010229 conserved gate region; other site 481743010230 ABC-ATPase subunit interface; other site 481743010231 NHL repeat; Region: NHL; pfam01436 481743010232 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743010233 binding surface 481743010234 TPR motif; other site 481743010235 Yip1 domain; Region: Yip1; cl17815 481743010236 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743010237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010238 dimer interface [polypeptide binding]; other site 481743010239 conserved gate region; other site 481743010240 putative PBP binding loops; other site 481743010241 ABC-ATPase subunit interface; other site 481743010242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010243 dimer interface [polypeptide binding]; other site 481743010244 conserved gate region; other site 481743010245 putative PBP binding loops; other site 481743010246 ABC-ATPase subunit interface; other site 481743010247 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 481743010248 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743010249 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743010250 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743010251 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743010252 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743010253 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743010254 DNA binding site [nucleotide binding] 481743010255 domain linker motif; other site 481743010256 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743010257 dimerization interface [polypeptide binding]; other site 481743010258 ligand binding site [chemical binding]; other site 481743010259 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 481743010260 Ligand Binding Site [chemical binding]; other site 481743010261 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 481743010262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743010263 putative substrate translocation pore; other site 481743010264 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 481743010265 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481743010266 non-specific DNA binding site [nucleotide binding]; other site 481743010267 salt bridge; other site 481743010268 sequence-specific DNA binding site [nucleotide binding]; other site 481743010269 Cupin domain; Region: Cupin_2; pfam07883 481743010270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743010271 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743010272 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 481743010273 hypothetical protein; Provisional; Region: PRK06184 481743010274 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 481743010275 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 481743010276 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743010277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743010278 Walker A/P-loop; other site 481743010279 ATP binding site [chemical binding]; other site 481743010280 Q-loop/lid; other site 481743010281 ABC transporter signature motif; other site 481743010282 Walker B; other site 481743010283 D-loop; other site 481743010284 H-loop/switch region; other site 481743010285 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 481743010286 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 481743010287 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743010288 Alcohol dehydrogenase GroES-associated; Region: ADH_N_assoc; pfam13823 481743010289 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743010290 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 481743010291 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 481743010292 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 481743010293 sugar binding site [chemical binding]; other site 481743010294 S-layer homology domain; Region: SLH; pfam00395 481743010295 S-layer homology domain; Region: SLH; pfam00395 481743010296 S-layer homology domain; Region: SLH; pfam00395 481743010297 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 481743010298 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 481743010299 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 481743010300 active site 481743010301 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 481743010302 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 481743010303 sugar binding site [chemical binding]; other site 481743010304 S-layer homology domain; Region: SLH; pfam00395 481743010305 S-layer homology domain; Region: SLH; pfam00395 481743010306 S-layer homology domain; Region: SLH; pfam00395 481743010307 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 481743010308 Beta-lactamase; Region: Beta-lactamase; pfam00144 481743010309 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743010310 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 481743010311 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 481743010312 DNA binding residues [nucleotide binding] 481743010313 putative dimer interface [polypeptide binding]; other site 481743010314 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481743010315 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481743010316 active site 481743010317 catalytic tetrad [active] 481743010318 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 481743010319 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 481743010320 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 481743010321 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 481743010322 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743010323 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 481743010324 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743010325 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 481743010326 Histidine kinase; Region: HisKA_3; pfam07730 481743010327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743010328 ATP binding site [chemical binding]; other site 481743010329 Mg2+ binding site [ion binding]; other site 481743010330 G-X-G motif; other site 481743010331 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743010332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743010333 active site 481743010334 phosphorylation site [posttranslational modification] 481743010335 intermolecular recognition site; other site 481743010336 dimerization interface [polypeptide binding]; other site 481743010337 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743010338 DNA binding residues [nucleotide binding] 481743010339 dimerization interface [polypeptide binding]; other site 481743010340 Putative sensor; Region: Sensor; pfam13796 481743010341 Erythromycin esterase; Region: Erythro_esteras; pfam05139 481743010342 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 481743010343 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 481743010344 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 481743010345 heme binding pocket [chemical binding]; other site 481743010346 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743010347 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743010348 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743010349 Cupin domain; Region: Cupin_2; pfam07883 481743010350 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743010351 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010352 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 481743010353 active site 481743010354 NTP binding site [chemical binding]; other site 481743010355 metal binding triad [ion binding]; metal-binding site 481743010356 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 481743010357 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 481743010358 putative NAD(P) binding site [chemical binding]; other site 481743010359 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743010360 dimerization interface [polypeptide binding]; other site 481743010361 putative DNA binding site [nucleotide binding]; other site 481743010362 putative Zn2+ binding site [ion binding]; other site 481743010363 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 481743010364 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 481743010365 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481743010366 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743010367 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010368 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 481743010369 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 481743010370 intersubunit interface [polypeptide binding]; other site 481743010371 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 481743010372 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 481743010373 intersubunit interface [polypeptide binding]; other site 481743010374 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 481743010375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743010376 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 481743010377 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 481743010378 DNA binding residues [nucleotide binding] 481743010379 drug binding residues [chemical binding]; other site 481743010380 dimer interface [polypeptide binding]; other site 481743010381 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 481743010382 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 481743010383 active site 481743010384 RibD C-terminal domain; Region: RibD_C; cl17279 481743010385 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 481743010386 short chain dehydrogenase; Provisional; Region: PRK06924 481743010387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743010388 NAD(P) binding site [chemical binding]; other site 481743010389 active site 481743010390 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743010391 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743010392 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 481743010393 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743010394 active site 481743010395 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 481743010396 conserved cys residue [active] 481743010397 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 481743010398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743010399 Walker A/P-loop; other site 481743010400 ATP binding site [chemical binding]; other site 481743010401 Q-loop/lid; other site 481743010402 ABC transporter signature motif; other site 481743010403 Walker B; other site 481743010404 D-loop; other site 481743010405 H-loop/switch region; other site 481743010406 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743010407 HAMP domain; Region: HAMP; pfam00672 481743010408 dimerization interface [polypeptide binding]; other site 481743010409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743010410 dimer interface [polypeptide binding]; other site 481743010411 phosphorylation site [posttranslational modification] 481743010412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743010413 ATP binding site [chemical binding]; other site 481743010414 Mg2+ binding site [ion binding]; other site 481743010415 G-X-G motif; other site 481743010416 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743010417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743010418 active site 481743010419 phosphorylation site [posttranslational modification] 481743010420 intermolecular recognition site; other site 481743010421 dimerization interface [polypeptide binding]; other site 481743010422 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743010423 DNA binding site [nucleotide binding] 481743010424 Protein of unknown function (DUF998); Region: DUF998; pfam06197 481743010425 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 481743010426 Cache domain; Region: Cache_1; pfam02743 481743010427 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743010428 Histidine kinase; Region: His_kinase; pfam06580 481743010429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743010430 ATP binding site [chemical binding]; other site 481743010431 Mg2+ binding site [ion binding]; other site 481743010432 G-X-G motif; other site 481743010433 Response regulator receiver domain; Region: Response_reg; pfam00072 481743010434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743010435 active site 481743010436 phosphorylation site [posttranslational modification] 481743010437 intermolecular recognition site; other site 481743010438 dimerization interface [polypeptide binding]; other site 481743010439 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010440 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743010441 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010442 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 481743010443 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743010444 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743010445 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743010446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010447 putative PBP binding loops; other site 481743010448 ABC-ATPase subunit interface; other site 481743010449 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743010450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010451 dimer interface [polypeptide binding]; other site 481743010452 conserved gate region; other site 481743010453 putative PBP binding loops; other site 481743010454 ABC-ATPase subunit interface; other site 481743010455 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 481743010456 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743010457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010458 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743010459 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743010460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 481743010461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010462 ABC-ATPase subunit interface; other site 481743010463 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743010464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010465 dimer interface [polypeptide binding]; other site 481743010466 conserved gate region; other site 481743010467 ABC-ATPase subunit interface; other site 481743010468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743010469 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743010470 dimerization interface [polypeptide binding]; other site 481743010471 Histidine kinase; Region: His_kinase; pfam06580 481743010472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743010473 ATP binding site [chemical binding]; other site 481743010474 Mg2+ binding site [ion binding]; other site 481743010475 G-X-G motif; other site 481743010476 Response regulator receiver domain; Region: Response_reg; pfam00072 481743010477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743010478 active site 481743010479 phosphorylation site [posttranslational modification] 481743010480 intermolecular recognition site; other site 481743010481 dimerization interface [polypeptide binding]; other site 481743010482 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010483 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743010484 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010485 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 481743010486 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010487 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743010488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010489 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 481743010490 RibD C-terminal domain; Region: RibD_C; cl17279 481743010491 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 481743010492 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 481743010493 RibD C-terminal domain; Region: RibD_C; cl17279 481743010494 sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678 481743010495 FAD binding domain; Region: FAD_binding_4; pfam01565 481743010496 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 481743010497 Response regulator receiver domain; Region: Response_reg; pfam00072 481743010498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743010499 active site 481743010500 phosphorylation site [posttranslational modification] 481743010501 intermolecular recognition site; other site 481743010502 dimerization interface [polypeptide binding]; other site 481743010503 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743010504 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010506 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743010507 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743010508 dimerization interface [polypeptide binding]; other site 481743010509 Histidine kinase; Region: His_kinase; pfam06580 481743010510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743010511 ATP binding site [chemical binding]; other site 481743010512 Mg2+ binding site [ion binding]; other site 481743010513 G-X-G motif; other site 481743010514 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743010515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010516 dimer interface [polypeptide binding]; other site 481743010517 conserved gate region; other site 481743010518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 481743010519 ABC-ATPase subunit interface; other site 481743010520 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743010521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010522 dimer interface [polypeptide binding]; other site 481743010523 conserved gate region; other site 481743010524 ABC-ATPase subunit interface; other site 481743010525 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743010526 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 481743010527 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 481743010528 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 481743010529 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 481743010530 inhibitor binding site; inhibition site 481743010531 active site 481743010532 putative dehydratase; Provisional; Region: PRK08211 481743010533 Dehydratase family; Region: ILVD_EDD; cl00340 481743010534 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 481743010535 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 481743010536 NAD(P) binding site [chemical binding]; other site 481743010537 catalytic residues [active] 481743010538 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 481743010539 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 481743010540 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743010541 Helix-turn-helix domain; Region: HTH_18; pfam12833 481743010542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010543 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743010544 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743010545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010546 dimer interface [polypeptide binding]; other site 481743010547 conserved gate region; other site 481743010548 ABC-ATPase subunit interface; other site 481743010549 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743010550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010551 dimer interface [polypeptide binding]; other site 481743010552 conserved gate region; other site 481743010553 ABC-ATPase subunit interface; other site 481743010554 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743010555 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010556 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 481743010557 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 481743010558 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 481743010559 Cupin domain; Region: Cupin_2; pfam07883 481743010560 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743010561 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010562 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010563 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743010564 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743010565 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 481743010566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 481743010567 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743010568 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743010569 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 481743010570 Walker A/P-loop; other site 481743010571 ATP binding site [chemical binding]; other site 481743010572 Q-loop/lid; other site 481743010573 ABC transporter signature motif; other site 481743010574 Walker B; other site 481743010575 D-loop; other site 481743010576 H-loop/switch region; other site 481743010577 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 481743010578 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743010579 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743010580 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 481743010581 Walker A/P-loop; other site 481743010582 ATP binding site [chemical binding]; other site 481743010583 Q-loop/lid; other site 481743010584 ABC transporter signature motif; other site 481743010585 Walker B; other site 481743010586 D-loop; other site 481743010587 H-loop/switch region; other site 481743010588 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 481743010589 Putative esterase; Region: Esterase; pfam00756 481743010590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 481743010591 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 481743010592 active site 481743010593 catalytic triad [active] 481743010594 oxyanion hole [active] 481743010595 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 481743010596 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 481743010597 active site 481743010598 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 481743010599 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 481743010600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743010601 active site 481743010602 dimerization interface [polypeptide binding]; other site 481743010603 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010604 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743010605 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010606 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 481743010607 substrate binding site [chemical binding]; other site 481743010608 active site 481743010609 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 481743010610 metal binding site [ion binding]; metal-binding site 481743010611 ligand binding site [chemical binding]; other site 481743010612 Response regulator receiver domain; Region: Response_reg; pfam00072 481743010613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743010614 active site 481743010615 phosphorylation site [posttranslational modification] 481743010616 intermolecular recognition site; other site 481743010617 dimerization interface [polypeptide binding]; other site 481743010618 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010619 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743010620 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010621 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743010622 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743010623 dimerization interface [polypeptide binding]; other site 481743010624 Histidine kinase; Region: His_kinase; pfam06580 481743010625 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 481743010626 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743010627 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743010628 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743010629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010630 ABC-ATPase subunit interface; other site 481743010631 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743010632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010633 dimer interface [polypeptide binding]; other site 481743010634 ABC-ATPase subunit interface; other site 481743010635 putative PBP binding loops; other site 481743010636 potential frameshift: common BLAST hit: gi|217967972|ref|YP_002353478.1| NHL repeat containing protein 481743010637 Yip1 domain; Region: Yip1; pfam04893 481743010638 NHL repeat; Region: NHL; pfam01436 481743010639 NHL repeat; Region: NHL; pfam01436 481743010640 Tetratricopeptide repeat; Region: TPR_12; pfam13424 481743010641 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743010642 binding surface 481743010643 TPR motif; other site 481743010644 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743010645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010646 dimer interface [polypeptide binding]; other site 481743010647 conserved gate region; other site 481743010648 ABC-ATPase subunit interface; other site 481743010649 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743010650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010651 dimer interface [polypeptide binding]; other site 481743010652 conserved gate region; other site 481743010653 putative PBP binding loops; other site 481743010654 ABC-ATPase subunit interface; other site 481743010655 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 481743010656 putative metal binding site [ion binding]; other site 481743010657 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 481743010658 putative metal binding site [ion binding]; other site 481743010659 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743010660 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743010661 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743010662 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743010663 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743010664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743010665 intermolecular recognition site; other site 481743010666 active site 481743010667 dimerization interface [polypeptide binding]; other site 481743010668 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010669 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743010670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010671 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 481743010672 AAA domain; Region: AAA_18; pfam13238 481743010673 P-loop motif; other site 481743010674 ATP binding site [chemical binding]; other site 481743010675 Chloramphenicol (Cm) binding site [chemical binding]; other site 481743010676 catalytic residue [active] 481743010677 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 481743010678 active site 481743010679 DinB family; Region: DinB; cl17821 481743010680 DinB superfamily; Region: DinB_2; pfam12867 481743010681 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 481743010682 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 481743010683 Cupin domain; Region: Cupin_2; pfam07883 481743010684 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743010685 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010686 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 481743010687 EamA-like transporter family; Region: EamA; pfam00892 481743010688 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743010689 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 481743010690 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 481743010691 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 481743010692 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 481743010693 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 481743010694 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743010695 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743010696 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743010697 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743010698 Response regulator receiver domain; Region: Response_reg; pfam00072 481743010699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743010700 active site 481743010701 phosphorylation site [posttranslational modification] 481743010702 intermolecular recognition site; other site 481743010703 dimerization interface [polypeptide binding]; other site 481743010704 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743010705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010706 HAMP domain; Region: HAMP; pfam00672 481743010707 dimerization interface [polypeptide binding]; other site 481743010708 Histidine kinase; Region: His_kinase; pfam06580 481743010709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743010710 ATP binding site [chemical binding]; other site 481743010711 Mg2+ binding site [ion binding]; other site 481743010712 G-X-G motif; other site 481743010713 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743010714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010715 dimer interface [polypeptide binding]; other site 481743010716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 481743010717 ABC-ATPase subunit interface; other site 481743010718 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743010719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010720 dimer interface [polypeptide binding]; other site 481743010721 conserved gate region; other site 481743010722 ABC-ATPase subunit interface; other site 481743010723 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743010724 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743010725 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743010726 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743010727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010728 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 481743010729 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 481743010730 LytTr DNA-binding domain; Region: LytTR; smart00850 481743010731 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 481743010732 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743010733 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481743010734 Walker A/P-loop; other site 481743010735 ATP binding site [chemical binding]; other site 481743010736 Q-loop/lid; other site 481743010737 ABC transporter signature motif; other site 481743010738 Walker B; other site 481743010739 D-loop; other site 481743010740 H-loop/switch region; other site 481743010741 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 481743010742 ABC-2 type transporter; Region: ABC2_membrane; cl17235 481743010743 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 481743010744 ABC-2 type transporter; Region: ABC2_membrane; cl17235 481743010745 Predicted transcriptional regulators [Transcription]; Region: COG1733 481743010746 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 481743010747 DoxX-like family; Region: DoxX_2; pfam13564 481743010748 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743010749 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743010750 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743010751 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481743010752 Walker A/P-loop; other site 481743010753 ATP binding site [chemical binding]; other site 481743010754 Q-loop/lid; other site 481743010755 ABC transporter signature motif; other site 481743010756 Walker B; other site 481743010757 D-loop; other site 481743010758 H-loop/switch region; other site 481743010759 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 481743010760 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 481743010761 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743010762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743010763 active site 481743010764 phosphorylation site [posttranslational modification] 481743010765 intermolecular recognition site; other site 481743010766 dimerization interface [polypeptide binding]; other site 481743010767 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743010768 DNA binding site [nucleotide binding] 481743010769 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743010770 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743010771 dimerization interface [polypeptide binding]; other site 481743010772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743010773 dimer interface [polypeptide binding]; other site 481743010774 phosphorylation site [posttranslational modification] 481743010775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743010776 ATP binding site [chemical binding]; other site 481743010777 Mg2+ binding site [ion binding]; other site 481743010778 G-X-G motif; other site 481743010779 PQQ-like domain; Region: PQQ_2; pfam13360 481743010780 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 481743010781 active site 481743010782 Trp docking motif [polypeptide binding]; other site 481743010783 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 481743010784 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 481743010785 Active site serine [active] 481743010786 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 481743010787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743010788 active site 481743010789 phosphorylation site [posttranslational modification] 481743010790 intermolecular recognition site; other site 481743010791 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743010792 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010793 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010794 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743010795 HAMP domain; Region: HAMP; pfam00672 481743010796 Histidine kinase; Region: His_kinase; pfam06580 481743010797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743010798 ATP binding site [chemical binding]; other site 481743010799 Mg2+ binding site [ion binding]; other site 481743010800 G-X-G motif; other site 481743010801 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743010802 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743010803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010804 dimer interface [polypeptide binding]; other site 481743010805 conserved gate region; other site 481743010806 putative PBP binding loops; other site 481743010807 ABC-ATPase subunit interface; other site 481743010808 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743010809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010810 dimer interface [polypeptide binding]; other site 481743010811 conserved gate region; other site 481743010812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 481743010813 ABC-ATPase subunit interface; other site 481743010814 Predicted permeases [General function prediction only]; Region: RarD; COG2962 481743010815 GTPase RsgA; Reviewed; Region: PRK01889 481743010816 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 481743010817 RNA binding site [nucleotide binding]; other site 481743010818 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 481743010819 GTPase/Zn-binding domain interface [polypeptide binding]; other site 481743010820 GTP/Mg2+ binding site [chemical binding]; other site 481743010821 G4 box; other site 481743010822 G5 box; other site 481743010823 G1 box; other site 481743010824 Switch I region; other site 481743010825 G2 box; other site 481743010826 G3 box; other site 481743010827 Switch II region; other site 481743010828 Phosphotransferase enzyme family; Region: APH; pfam01636 481743010829 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 481743010830 active site 481743010831 ATP binding site [chemical binding]; other site 481743010832 substrate binding site [chemical binding]; other site 481743010833 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743010834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743010835 Walker A/P-loop; other site 481743010836 ATP binding site [chemical binding]; other site 481743010837 Q-loop/lid; other site 481743010838 ABC transporter signature motif; other site 481743010839 Walker B; other site 481743010840 D-loop; other site 481743010841 H-loop/switch region; other site 481743010842 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 481743010843 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 481743010844 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 481743010845 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 481743010846 Uncharacterized conserved protein [Function unknown]; Region: COG3339 481743010847 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 481743010848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743010849 NADH(P)-binding; Region: NAD_binding_10; pfam13460 481743010850 NAD(P) binding site [chemical binding]; other site 481743010851 active site 481743010852 Predicted transcriptional regulators [Transcription]; Region: COG1733 481743010853 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743010854 dimerization interface [polypeptide binding]; other site 481743010855 putative DNA binding site [nucleotide binding]; other site 481743010856 putative Zn2+ binding site [ion binding]; other site 481743010857 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 481743010858 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743010859 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010860 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 481743010861 DNA-binding ferritin-like protein (Dps family) [General function prediction only]; Region: COG4817 481743010862 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 481743010863 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 481743010864 metal binding site [ion binding]; metal-binding site 481743010865 substrate binding pocket [chemical binding]; other site 481743010866 OsmC-like protein; Region: OsmC; pfam02566 481743010867 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 481743010868 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 481743010869 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743010870 Walker A/P-loop; other site 481743010871 ATP binding site [chemical binding]; other site 481743010872 Q-loop/lid; other site 481743010873 ABC transporter signature motif; other site 481743010874 Walker B; other site 481743010875 D-loop; other site 481743010876 H-loop/switch region; other site 481743010877 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 481743010878 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 481743010879 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743010880 Walker A/P-loop; other site 481743010881 ATP binding site [chemical binding]; other site 481743010882 Q-loop/lid; other site 481743010883 ABC transporter signature motif; other site 481743010884 Walker B; other site 481743010885 D-loop; other site 481743010886 H-loop/switch region; other site 481743010887 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 481743010888 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 481743010889 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 481743010890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010891 dimer interface [polypeptide binding]; other site 481743010892 conserved gate region; other site 481743010893 putative PBP binding loops; other site 481743010894 ABC-ATPase subunit interface; other site 481743010895 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 481743010896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743010897 dimer interface [polypeptide binding]; other site 481743010898 conserved gate region; other site 481743010899 putative PBP binding loops; other site 481743010900 ABC-ATPase subunit interface; other site 481743010901 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 481743010902 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 481743010903 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 481743010904 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 481743010905 inhibitor site; inhibition site 481743010906 active site 481743010907 dimer interface [polypeptide binding]; other site 481743010908 catalytic residue [active] 481743010909 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 481743010910 EamA-like transporter family; Region: EamA; cl17759 481743010911 EamA-like transporter family; Region: EamA; pfam00892 481743010912 DinB family; Region: DinB; cl17821 481743010913 DinB superfamily; Region: DinB_2; pfam12867 481743010914 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743010915 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743010916 dimer interface [polypeptide binding]; other site 481743010917 phosphorylation site [posttranslational modification] 481743010918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743010919 ATP binding site [chemical binding]; other site 481743010920 Mg2+ binding site [ion binding]; other site 481743010921 G-X-G motif; other site 481743010922 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 481743010923 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 481743010924 FtsX-like permease family; Region: FtsX; pfam02687 481743010925 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 481743010926 FtsX-like permease family; Region: FtsX; pfam02687 481743010927 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 481743010928 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 481743010929 Walker A/P-loop; other site 481743010930 ATP binding site [chemical binding]; other site 481743010931 Q-loop/lid; other site 481743010932 ABC transporter signature motif; other site 481743010933 Walker B; other site 481743010934 D-loop; other site 481743010935 H-loop/switch region; other site 481743010936 VanZ like family; Region: VanZ; pfam04892 481743010937 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743010938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743010939 dimer interface [polypeptide binding]; other site 481743010940 phosphorylation site [posttranslational modification] 481743010941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743010942 ATP binding site [chemical binding]; other site 481743010943 Mg2+ binding site [ion binding]; other site 481743010944 G-X-G motif; other site 481743010945 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743010946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743010947 active site 481743010948 phosphorylation site [posttranslational modification] 481743010949 intermolecular recognition site; other site 481743010950 dimerization interface [polypeptide binding]; other site 481743010951 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743010952 DNA binding site [nucleotide binding] 481743010953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743010954 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743010955 putative substrate translocation pore; other site 481743010956 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 481743010957 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 481743010958 NodB motif; other site 481743010959 active site 481743010960 catalytic site [active] 481743010961 metal binding site [ion binding]; metal-binding site 481743010962 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743010963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743010964 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 481743010965 dimerization interface [polypeptide binding]; other site 481743010966 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481743010967 MarR family; Region: MarR; pfam01047 481743010968 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 481743010969 FMN binding site [chemical binding]; other site 481743010970 dimer interface [polypeptide binding]; other site 481743010971 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 481743010972 FMN binding site [chemical binding]; other site 481743010973 dimer interface [polypeptide binding]; other site 481743010974 DoxX-like family; Region: DoxX_2; pfam13564 481743010975 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 481743010976 Lamin Tail Domain; Region: LTD; pfam00932 481743010977 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 481743010978 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 481743010979 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 481743010980 putative active site [active] 481743010981 putative metal binding site [ion binding]; other site 481743010982 S-layer homology domain; Region: SLH; pfam00395 481743010983 S-layer homology domain; Region: SLH; pfam00395 481743010984 cytosine deaminase; Provisional; Region: PRK09230 481743010985 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 481743010986 active site 481743010987 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 481743010988 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 481743010989 Na binding site [ion binding]; other site 481743010990 putative substrate binding site [chemical binding]; other site 481743010991 chloramphenicol/florfenicol resistance protein; Provisional; Region: PRK14453 481743010992 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743010993 FeS/SAM binding site; other site 481743010994 Helix-turn-helix domain; Region: HTH_18; pfam12833 481743010995 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743010996 Epoxide hydrolase N terminus; Region: EHN; pfam06441 481743010997 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 481743010998 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 481743010999 active site 481743011000 catalytic triad [active] 481743011001 oxyanion hole [active] 481743011002 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 481743011003 Domain of unknown function (DUF377); Region: DUF377; pfam04041 481743011004 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 481743011005 active site 481743011006 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743011007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743011008 dimer interface [polypeptide binding]; other site 481743011009 conserved gate region; other site 481743011010 putative PBP binding loops; other site 481743011011 ABC-ATPase subunit interface; other site 481743011012 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743011013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743011014 ABC-ATPase subunit interface; other site 481743011015 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743011016 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743011017 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 481743011018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743011019 active site 481743011020 phosphorylation site [posttranslational modification] 481743011021 intermolecular recognition site; other site 481743011022 dimerization interface [polypeptide binding]; other site 481743011023 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743011024 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743011025 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743011026 dimerization interface [polypeptide binding]; other site 481743011027 Histidine kinase; Region: His_kinase; pfam06580 481743011028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743011029 ATP binding site [chemical binding]; other site 481743011030 Mg2+ binding site [ion binding]; other site 481743011031 G-X-G motif; other site 481743011032 Probable transposase; Region: OrfB_IS605; pfam01385 481743011033 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 481743011034 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 481743011035 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 481743011036 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 481743011037 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 481743011038 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 481743011039 Ca2+ binding site [ion binding]; other site 481743011040 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 481743011041 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 481743011042 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 481743011043 tetramer interface [polypeptide binding]; other site 481743011044 active site 481743011045 Mg2+/Mn2+ binding site [ion binding]; other site 481743011046 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 481743011047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 481743011048 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 481743011049 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 481743011050 dimer interface [polypeptide binding]; other site 481743011051 Predicted transcriptional regulator [Transcription]; Region: COG2378 481743011052 HTH domain; Region: HTH_11; pfam08279 481743011053 WYL domain; Region: WYL; pfam13280 481743011054 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 481743011055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743011056 DNA-binding site [nucleotide binding]; DNA binding site 481743011057 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743011058 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 481743011059 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 481743011060 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 481743011061 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 481743011062 inhibitor-cofactor binding pocket; inhibition site 481743011063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743011064 catalytic residue [active] 481743011065 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 481743011066 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743011067 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743011068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743011069 dimer interface [polypeptide binding]; other site 481743011070 conserved gate region; other site 481743011071 putative PBP binding loops; other site 481743011072 ABC-ATPase subunit interface; other site 481743011073 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743011074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743011075 dimer interface [polypeptide binding]; other site 481743011076 conserved gate region; other site 481743011077 ABC-ATPase subunit interface; other site 481743011078 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 481743011079 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 481743011080 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 481743011081 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 481743011082 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 481743011083 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 481743011084 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 481743011085 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 481743011086 DNA binding residues [nucleotide binding] 481743011087 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 481743011088 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 481743011089 DNA binding residues [nucleotide binding] 481743011090 ABC-2 type transporter; Region: ABC2_membrane; cl17235 481743011091 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 481743011092 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 481743011093 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743011094 Walker A/P-loop; other site 481743011095 ATP binding site [chemical binding]; other site 481743011096 Q-loop/lid; other site 481743011097 ABC transporter signature motif; other site 481743011098 Walker B; other site 481743011099 D-loop; other site 481743011100 H-loop/switch region; other site 481743011101 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 481743011102 Predicted transcriptional regulators [Transcription]; Region: COG1695 481743011103 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 481743011104 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 481743011105 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_3; cd09002 481743011106 active site 481743011107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743011108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743011109 dimer interface [polypeptide binding]; other site 481743011110 phosphorylation site [posttranslational modification] 481743011111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743011112 ATP binding site [chemical binding]; other site 481743011113 Mg2+ binding site [ion binding]; other site 481743011114 G-X-G motif; other site 481743011115 Response regulator receiver domain; Region: Response_reg; pfam00072 481743011116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743011117 active site 481743011118 phosphorylation site [posttranslational modification] 481743011119 intermolecular recognition site; other site 481743011120 dimerization interface [polypeptide binding]; other site 481743011121 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743011122 Histidine kinase; Region: His_kinase; pfam06580 481743011123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743011124 ATP binding site [chemical binding]; other site 481743011125 Mg2+ binding site [ion binding]; other site 481743011126 G-X-G motif; other site 481743011127 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743011128 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743011129 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 481743011130 dimerization interface [polypeptide binding]; other site 481743011131 hypothetical protein; Validated; Region: PRK07581 481743011132 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 481743011133 Predicted acetyltransferase [General function prediction only]; Region: COG3981 481743011134 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 481743011135 Coenzyme A binding pocket [chemical binding]; other site 481743011136 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 481743011137 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 481743011138 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 481743011139 intersubunit interface [polypeptide binding]; other site 481743011140 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 481743011141 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 481743011142 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 481743011143 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481743011144 ABC-ATPase subunit interface; other site 481743011145 dimer interface [polypeptide binding]; other site 481743011146 putative PBP binding regions; other site 481743011147 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 481743011148 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 481743011149 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 481743011150 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 481743011151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743011152 Coenzyme A binding pocket [chemical binding]; other site 481743011153 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481743011154 MarR family; Region: MarR; pfam01047 481743011155 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743011156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743011157 active site 481743011158 phosphorylation site [posttranslational modification] 481743011159 intermolecular recognition site; other site 481743011160 dimerization interface [polypeptide binding]; other site 481743011161 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743011162 DNA binding site [nucleotide binding] 481743011163 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743011164 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743011165 dimerization interface [polypeptide binding]; other site 481743011166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743011167 dimer interface [polypeptide binding]; other site 481743011168 phosphorylation site [posttranslational modification] 481743011169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743011170 ATP binding site [chemical binding]; other site 481743011171 Mg2+ binding site [ion binding]; other site 481743011172 G-X-G motif; other site 481743011173 Beta-lactamase; Region: Beta-lactamase; pfam00144 481743011174 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 481743011175 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 481743011176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743011177 putative substrate translocation pore; other site 481743011178 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 481743011179 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 481743011180 putative NAD(P) binding site [chemical binding]; other site 481743011181 putative substrate binding site [chemical binding]; other site 481743011182 catalytic Zn binding site [ion binding]; other site 481743011183 structural Zn binding site [ion binding]; other site 481743011184 dimer interface [polypeptide binding]; other site 481743011185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743011186 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 481743011187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743011188 NAD(P) binding site [chemical binding]; other site 481743011189 active site 481743011190 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 481743011191 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 481743011192 trimer interface [polypeptide binding]; other site 481743011193 active site 481743011194 substrate binding site [chemical binding]; other site 481743011195 CoA binding site [chemical binding]; other site 481743011196 putative transport protein YifK; Provisional; Region: PRK10746 481743011197 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 481743011198 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 481743011199 active site 481743011200 metal binding site [ion binding]; metal-binding site 481743011201 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 481743011202 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 481743011203 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 481743011204 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 481743011205 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 481743011206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743011207 dimer interface [polypeptide binding]; other site 481743011208 conserved gate region; other site 481743011209 putative PBP binding loops; other site 481743011210 ABC-ATPase subunit interface; other site 481743011211 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 481743011212 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 481743011213 DNA binding domain, excisionase family; Region: excise; TIGR01764 481743011214 PBP superfamily domain; Region: PBP_like; pfam12727 481743011215 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743011216 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 481743011217 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743011218 dimerization interface [polypeptide binding]; other site 481743011219 putative DNA binding site [nucleotide binding]; other site 481743011220 putative Zn2+ binding site [ion binding]; other site 481743011221 phosphoenolpyruvate synthase; Validated; Region: PRK06241 481743011222 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 481743011223 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 481743011224 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 481743011225 HTH domain; Region: HTH_11; pfam08279 481743011226 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 481743011227 DNA binding residues [nucleotide binding] 481743011228 WYL domain; Region: WYL; pfam13280 481743011229 DinB family; Region: DinB; cl17821 481743011230 DinB superfamily; Region: DinB_2; pfam12867 481743011231 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 481743011232 EcsC protein family; Region: EcsC; pfam12787 481743011233 glycosyl hydrolase 64 family; Region: GH64-like; cd09214 481743011234 substrate binding pocket [chemical binding]; other site 481743011235 catalytic residues [active] 481743011236 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 481743011237 DinB superfamily; Region: DinB_2; pfam12867 481743011238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743011239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743011240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 481743011241 dimerization interface [polypeptide binding]; other site 481743011242 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743011243 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 481743011244 active site 481743011245 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 481743011246 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743011247 DNA-binding site [nucleotide binding]; DNA binding site 481743011248 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743011249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743011250 homodimer interface [polypeptide binding]; other site 481743011251 catalytic residue [active] 481743011252 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 481743011253 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 481743011254 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 481743011255 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 481743011256 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 481743011257 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743011258 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 481743011259 Walker A/P-loop; other site 481743011260 ATP binding site [chemical binding]; other site 481743011261 Q-loop/lid; other site 481743011262 ABC transporter signature motif; other site 481743011263 Walker B; other site 481743011264 D-loop; other site 481743011265 H-loop/switch region; other site 481743011266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743011267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743011268 dimer interface [polypeptide binding]; other site 481743011269 phosphorylation site [posttranslational modification] 481743011270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743011271 ATP binding site [chemical binding]; other site 481743011272 Mg2+ binding site [ion binding]; other site 481743011273 G-X-G motif; other site 481743011274 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743011275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743011276 active site 481743011277 phosphorylation site [posttranslational modification] 481743011278 intermolecular recognition site; other site 481743011279 dimerization interface [polypeptide binding]; other site 481743011280 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743011281 DNA binding site [nucleotide binding] 481743011282 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 481743011283 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 481743011284 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743011285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743011286 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 481743011287 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 481743011288 DNA binding residues [nucleotide binding] 481743011289 putative dimer interface [polypeptide binding]; other site 481743011290 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481743011291 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481743011292 active site 481743011293 catalytic tetrad [active] 481743011294 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743011295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743011296 putative substrate translocation pore; other site 481743011297 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743011298 dimerization interface [polypeptide binding]; other site 481743011299 putative DNA binding site [nucleotide binding]; other site 481743011300 putative Zn2+ binding site [ion binding]; other site 481743011301 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 481743011302 active site residue [active] 481743011303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 481743011304 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 481743011305 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 481743011306 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 481743011307 Part of AAA domain; Region: AAA_19; pfam13245 481743011308 Family description; Region: UvrD_C_2; pfam13538 481743011309 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 481743011310 substrate binding pocket [chemical binding]; other site 481743011311 substrate-Mg2+ binding site; other site 481743011312 aspartate-rich region 1; other site 481743011313 aspartate-rich region 2; other site 481743011314 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 481743011315 H+ Antiporter protein; Region: 2A0121; TIGR00900 481743011316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743011317 putative substrate translocation pore; other site 481743011318 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 481743011319 Phosphotransferase enzyme family; Region: APH; pfam01636 481743011320 putative active site [active] 481743011321 putative substrate binding site [chemical binding]; other site 481743011322 ATP binding site [chemical binding]; other site 481743011323 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 481743011324 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 481743011325 dimer interface [polypeptide binding]; other site 481743011326 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743011327 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 481743011328 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743011329 Coenzyme A binding pocket [chemical binding]; other site 481743011330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743011331 S-adenosylmethionine binding site [chemical binding]; other site 481743011332 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 481743011333 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743011334 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 481743011335 Walker A/P-loop; other site 481743011336 ATP binding site [chemical binding]; other site 481743011337 Q-loop/lid; other site 481743011338 ABC transporter signature motif; other site 481743011339 Walker B; other site 481743011340 D-loop; other site 481743011341 H-loop/switch region; other site 481743011342 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 481743011343 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743011344 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 481743011345 Walker A/P-loop; other site 481743011346 ATP binding site [chemical binding]; other site 481743011347 Q-loop/lid; other site 481743011348 ABC transporter signature motif; other site 481743011349 Walker B; other site 481743011350 D-loop; other site 481743011351 H-loop/switch region; other site 481743011352 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 481743011353 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 481743011354 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 481743011355 YtkA-like; Region: YtkA; pfam13115 481743011356 Family description; Region: DsbD_2; pfam13386 481743011357 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 481743011358 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 481743011359 metal-binding site [ion binding] 481743011360 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 481743011361 Soluble P-type ATPase [General function prediction only]; Region: COG4087 481743011362 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743011363 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 481743011364 Uncharacterized conserved protein [Function unknown]; Region: COG5646 481743011365 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 481743011366 FAD binding pocket [chemical binding]; other site 481743011367 conserved FAD binding motif [chemical binding]; other site 481743011368 phosphate binding motif [ion binding]; other site 481743011369 beta-alpha-beta structure motif; other site 481743011370 NAD binding pocket [chemical binding]; other site 481743011371 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743011372 Walker A/P-loop; other site 481743011373 ATP binding site [chemical binding]; other site 481743011374 Q-loop/lid; other site 481743011375 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 481743011376 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 481743011377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743011378 Walker A/P-loop; other site 481743011379 ATP binding site [chemical binding]; other site 481743011380 Q-loop/lid; other site 481743011381 ABC transporter signature motif; other site 481743011382 Walker B; other site 481743011383 D-loop; other site 481743011384 H-loop/switch region; other site 481743011385 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 481743011386 putative hydrophobic ligand binding site [chemical binding]; other site 481743011387 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743011388 dimerization interface [polypeptide binding]; other site 481743011389 putative DNA binding site [nucleotide binding]; other site 481743011390 putative Zn2+ binding site [ion binding]; other site 481743011391 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 481743011392 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 481743011393 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 481743011394 DNA binding residues [nucleotide binding] 481743011395 dimer interface [polypeptide binding]; other site 481743011396 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 481743011397 active site 481743011398 Mn binding site [ion binding]; other site 481743011399 Predicted transcriptional regulators [Transcription]; Region: COG1733 481743011400 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743011401 putative DNA binding site [nucleotide binding]; other site 481743011402 dimerization interface [polypeptide binding]; other site 481743011403 putative Zn2+ binding site [ion binding]; other site 481743011404 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 481743011405 Uncharacterized conserved protein [Function unknown]; Region: COG1262 481743011406 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 481743011407 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 481743011408 A new structural DNA glycosylase; Region: AlkD_like; cd06561 481743011409 active site 481743011410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743011411 H+ Antiporter protein; Region: 2A0121; TIGR00900 481743011412 putative substrate translocation pore; other site 481743011413 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 481743011414 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481743011415 ABC transporter; Region: ABC_tran_2; pfam12848 481743011416 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481743011417 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481743011418 salt bridge; other site 481743011419 non-specific DNA binding site [nucleotide binding]; other site 481743011420 sequence-specific DNA binding site [nucleotide binding]; other site 481743011421 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 481743011422 glutathione reductase; Validated; Region: PRK06116 481743011423 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 481743011424 active site 481743011425 catalytic residues [active] 481743011426 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 481743011427 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 481743011428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743011429 putative substrate translocation pore; other site 481743011430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743011431 H+ Antiporter protein; Region: 2A0121; TIGR00900 481743011432 putative substrate translocation pore; other site 481743011433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743011434 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 481743011435 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743011436 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743011437 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 481743011438 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 481743011439 active site 481743011440 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743011441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743011442 dimer interface [polypeptide binding]; other site 481743011443 conserved gate region; other site 481743011444 putative PBP binding loops; other site 481743011445 ABC-ATPase subunit interface; other site 481743011446 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743011447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743011448 dimer interface [polypeptide binding]; other site 481743011449 conserved gate region; other site 481743011450 putative PBP binding loops; other site 481743011451 ABC-ATPase subunit interface; other site 481743011452 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743011453 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743011454 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743011455 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743011456 DNA binding site [nucleotide binding] 481743011457 domain linker motif; other site 481743011458 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743011459 dimerization interface [polypeptide binding]; other site 481743011460 ligand binding site [chemical binding]; other site 481743011461 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 481743011462 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 481743011463 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743011464 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743011465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743011466 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 481743011467 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743011468 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743011469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743011470 dimer interface [polypeptide binding]; other site 481743011471 conserved gate region; other site 481743011472 putative PBP binding loops; other site 481743011473 ABC-ATPase subunit interface; other site 481743011474 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743011475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743011476 dimer interface [polypeptide binding]; other site 481743011477 conserved gate region; other site 481743011478 ABC-ATPase subunit interface; other site 481743011479 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 481743011480 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 481743011481 beta-D-glucuronidase; Provisional; Region: PRK10150 481743011482 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 481743011483 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 481743011484 Glycosyl hydrolase families 43 and 62 form CAZY clan GH-F; Region: GH_F; cd08978 481743011485 active site 481743011486 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 481743011487 putative metal binding site [ion binding]; other site 481743011488 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743011489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743011490 dimer interface [polypeptide binding]; other site 481743011491 conserved gate region; other site 481743011492 putative PBP binding loops; other site 481743011493 ABC-ATPase subunit interface; other site 481743011494 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743011495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743011496 dimer interface [polypeptide binding]; other site 481743011497 conserved gate region; other site 481743011498 putative PBP binding loops; other site 481743011499 ABC-ATPase subunit interface; other site 481743011500 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743011501 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743011502 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 481743011503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743011504 DNA-binding site [nucleotide binding]; DNA binding site 481743011505 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743011506 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 481743011507 ligand binding site [chemical binding]; other site 481743011508 dimerization interface [polypeptide binding]; other site 481743011509 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743011510 DNA-binding site [nucleotide binding]; DNA binding site 481743011511 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 481743011512 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743011513 dimerization interface [polypeptide binding]; other site 481743011514 ligand binding site [chemical binding]; other site 481743011515 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 481743011516 catalytic site [active] 481743011517 Asp-box motif; other site 481743011518 RNA polymerase sigma factor; Provisional; Region: PRK11924 481743011519 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743011520 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743011521 DNA binding residues [nucleotide binding] 481743011522 Small acid-soluble spore protein H family; Region: SspH; pfam08141 481743011523 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 481743011524 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 481743011525 putative active site [active] 481743011526 putative metal binding site [ion binding]; other site 481743011527 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 481743011528 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 481743011529 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 481743011530 active site 481743011531 dimer interface [polypeptide binding]; other site 481743011532 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 481743011533 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 481743011534 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 481743011535 Domain of unknown function (DUF336); Region: DUF336; pfam03928 481743011536 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 481743011537 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 481743011538 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 481743011539 PQQ-like domain; Region: PQQ_2; pfam13360 481743011540 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743011541 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 481743011542 DNA-binding site [nucleotide binding]; DNA binding site 481743011543 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743011544 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743011545 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 481743011546 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 481743011547 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 481743011548 inhibitor site; inhibition site 481743011549 active site 481743011550 dimer interface [polypeptide binding]; other site 481743011551 catalytic residue [active] 481743011552 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 481743011553 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 481743011554 putative ligand binding site [chemical binding]; other site 481743011555 putative NAD binding site [chemical binding]; other site 481743011556 catalytic site [active] 481743011557 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743011558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743011559 dimer interface [polypeptide binding]; other site 481743011560 conserved gate region; other site 481743011561 putative PBP binding loops; other site 481743011562 ABC-ATPase subunit interface; other site 481743011563 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743011564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743011565 dimer interface [polypeptide binding]; other site 481743011566 conserved gate region; other site 481743011567 putative PBP binding loops; other site 481743011568 ABC-ATPase subunit interface; other site 481743011569 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743011570 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743011571 Response regulator receiver domain; Region: Response_reg; pfam00072 481743011572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743011573 active site 481743011574 phosphorylation site [posttranslational modification] 481743011575 intermolecular recognition site; other site 481743011576 dimerization interface [polypeptide binding]; other site 481743011577 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743011578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743011579 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743011580 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743011581 dimerization interface [polypeptide binding]; other site 481743011582 Histidine kinase; Region: His_kinase; pfam06580 481743011583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743011584 ATP binding site [chemical binding]; other site 481743011585 Mg2+ binding site [ion binding]; other site 481743011586 G-X-G motif; other site 481743011587 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743011588 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 481743011589 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743011590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743011591 Coenzyme A binding pocket [chemical binding]; other site 481743011592 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 481743011593 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743011594 Coenzyme A binding pocket [chemical binding]; other site 481743011595 arylsulfatase; Provisional; Region: PRK13759 481743011596 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 481743011597 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 481743011598 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 481743011599 FAD binding domain; Region: FAD_binding_4; pfam01565 481743011600 Berberine and berberine like; Region: BBE; pfam08031 481743011601 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 481743011602 aspartate racemase; Region: asp_race; TIGR00035 481743011603 Protein of unknown function DUF45; Region: DUF45; pfam01863 481743011604 HPr kinase/phosphorylase; Provisional; Region: PRK05428 481743011605 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 481743011606 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 481743011607 Hpr binding site; other site 481743011608 active site 481743011609 homohexamer subunit interaction site [polypeptide binding]; other site 481743011610 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 481743011611 structural tetrad; other site 481743011612 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 481743011613 dimer interface [polypeptide binding]; other site 481743011614 putative tRNA-binding site [nucleotide binding]; other site 481743011615 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 481743011616 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 481743011617 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743011618 DNA-binding site [nucleotide binding]; DNA binding site 481743011619 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743011620 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743011621 homodimer interface [polypeptide binding]; other site 481743011622 catalytic residue [active] 481743011623 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 481743011624 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 481743011625 dimer interface [polypeptide binding]; other site 481743011626 NAD binding site [chemical binding]; other site 481743011627 substrate binding site [chemical binding]; other site 481743011628 tetramer (dimer of dimers) interface [polypeptide binding]; other site 481743011629 LysE type translocator; Region: LysE; cl00565 481743011630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481743011631 salt bridge; other site 481743011632 non-specific DNA binding site [nucleotide binding]; other site 481743011633 sequence-specific DNA binding site [nucleotide binding]; other site 481743011634 Cupin domain; Region: Cupin_2; pfam07883 481743011635 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 481743011636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743011637 dimer interface [polypeptide binding]; other site 481743011638 conserved gate region; other site 481743011639 putative PBP binding loops; other site 481743011640 ABC-ATPase subunit interface; other site 481743011641 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 481743011642 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 481743011643 Walker A/P-loop; other site 481743011644 ATP binding site [chemical binding]; other site 481743011645 Q-loop/lid; other site 481743011646 ABC transporter signature motif; other site 481743011647 Walker B; other site 481743011648 D-loop; other site 481743011649 H-loop/switch region; other site 481743011650 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 481743011651 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 481743011652 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 481743011653 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481743011654 MarR family; Region: MarR; pfam01047 481743011655 dimerization interface [polypeptide binding]; other site 481743011656 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 481743011657 putative active cleft [active] 481743011658 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743011659 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743011660 DNA binding site [nucleotide binding] 481743011661 domain linker motif; other site 481743011662 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 481743011663 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 481743011664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743011665 putative substrate translocation pore; other site 481743011666 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743011667 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 481743011668 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743011669 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743011670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743011671 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 481743011672 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743011673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743011674 homodimer interface [polypeptide binding]; other site 481743011675 catalytic residue [active] 481743011676 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 481743011677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743011678 putative substrate translocation pore; other site 481743011679 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 481743011680 dimerization interface [polypeptide binding]; other site 481743011681 Chloramphenicol acetyltransferase; Region: CAT; cl02008 481743011682 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 481743011683 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743011684 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 481743011685 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 481743011686 catalytic core [active] 481743011687 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743011688 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 481743011689 active site 481743011690 Domain of unknown function, E. rectale Gene description (DUF3881); Region: DUF3881; pfam12997 481743011691 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743011692 Coenzyme A binding pocket [chemical binding]; other site 481743011693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743011694 S-adenosylmethionine binding site [chemical binding]; other site 481743011695 Mor transcription activator family; Region: Mor; cl02360 481743011696 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 481743011697 active site 481743011698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743011699 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 481743011700 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 481743011701 catalytic residue [active] 481743011702 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 481743011703 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 481743011704 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 481743011705 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 481743011706 histidyl-tRNA synthetase; Provisional; Region: PRK12420 481743011707 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 481743011708 dimer interface [polypeptide binding]; other site 481743011709 motif 1; other site 481743011710 active site 481743011711 motif 2; other site 481743011712 motif 3; other site 481743011713 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 481743011714 anticodon binding site; other site 481743011715 hydroperoxidase II; Provisional; Region: katE; PRK11249 481743011716 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 481743011717 tetramer interface [polypeptide binding]; other site 481743011718 heme binding pocket [chemical binding]; other site 481743011719 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 481743011720 domain interactions; other site 481743011721 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 481743011722 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743011723 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743011724 DNA binding residues [nucleotide binding] 481743011725 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 481743011726 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481743011727 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 481743011728 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743011729 DNA-binding site [nucleotide binding]; DNA binding site 481743011730 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743011731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743011732 homodimer interface [polypeptide binding]; other site 481743011733 catalytic residue [active] 481743011734 EamA-like transporter family; Region: EamA; pfam00892 481743011735 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 481743011736 EamA-like transporter family; Region: EamA; pfam00892 481743011737 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 481743011738 lipoyl attachment site [posttranslational modification]; other site 481743011739 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 481743011740 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 481743011741 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 481743011742 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 481743011743 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 481743011744 tetramer interface [polypeptide binding]; other site 481743011745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743011746 catalytic residue [active] 481743011747 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 481743011748 tetramer interface [polypeptide binding]; other site 481743011749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743011750 catalytic residue [active] 481743011751 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 481743011752 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 481743011753 nucleoside/Zn binding site; other site 481743011754 dimer interface [polypeptide binding]; other site 481743011755 catalytic motif [active] 481743011756 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743011757 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743011758 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 481743011759 Walker A/P-loop; other site 481743011760 ATP binding site [chemical binding]; other site 481743011761 Q-loop/lid; other site 481743011762 ABC transporter signature motif; other site 481743011763 Walker B; other site 481743011764 D-loop; other site 481743011765 H-loop/switch region; other site 481743011766 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743011767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743011768 active site 481743011769 phosphorylation site [posttranslational modification] 481743011770 intermolecular recognition site; other site 481743011771 dimerization interface [polypeptide binding]; other site 481743011772 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743011773 DNA binding residues [nucleotide binding] 481743011774 dimerization interface [polypeptide binding]; other site 481743011775 Histidine kinase; Region: HisKA_3; pfam07730 481743011776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743011777 ATP binding site [chemical binding]; other site 481743011778 Mg2+ binding site [ion binding]; other site 481743011779 G-X-G motif; other site 481743011780 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 481743011781 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743011782 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743011783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743011784 Walker A/P-loop; other site 481743011785 ATP binding site [chemical binding]; other site 481743011786 Q-loop/lid; other site 481743011787 ABC transporter signature motif; other site 481743011788 Walker B; other site 481743011789 D-loop; other site 481743011790 H-loop/switch region; other site 481743011791 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743011792 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743011793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743011794 Walker A/P-loop; other site 481743011795 ATP binding site [chemical binding]; other site 481743011796 Q-loop/lid; other site 481743011797 ABC transporter signature motif; other site 481743011798 Walker B; other site 481743011799 D-loop; other site 481743011800 H-loop/switch region; other site 481743011801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743011802 binding surface 481743011803 TPR motif; other site 481743011804 Tetratrico peptide repeat; Region: TPR_5; pfam12688 481743011805 MMPL family; Region: MMPL; pfam03176 481743011806 MMPL family; Region: MMPL; pfam03176 481743011807 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 481743011808 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743011809 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743011810 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 481743011811 dimer interface [polypeptide binding]; other site 481743011812 FMN binding site [chemical binding]; other site 481743011813 Transcriptional regulator; Region: Rrf2; pfam02082 481743011814 Rrf2 family protein; Region: rrf2_super; TIGR00738 481743011815 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 481743011816 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 481743011817 classical (c) SDRs; Region: SDR_c; cd05233 481743011818 NAD(P) binding site [chemical binding]; other site 481743011819 active site 481743011820 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743011821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743011822 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 481743011823 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743011824 putative DNA binding site [nucleotide binding]; other site 481743011825 putative Zn2+ binding site [ion binding]; other site 481743011826 AsnC family; Region: AsnC_trans_reg; pfam01037 481743011827 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 481743011828 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 481743011829 phosphate binding site [ion binding]; other site 481743011830 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743011831 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743011832 DNA binding site [nucleotide binding] 481743011833 domain linker motif; other site 481743011834 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743011835 dimerization interface [polypeptide binding]; other site 481743011836 ligand binding site [chemical binding]; other site 481743011837 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 481743011838 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743011839 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743011840 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743011841 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 481743011842 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 481743011843 tetrameric interface [polypeptide binding]; other site 481743011844 NAD binding site [chemical binding]; other site 481743011845 catalytic residues [active] 481743011846 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 481743011847 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 481743011848 substrate binding site [chemical binding]; other site 481743011849 ATP binding site [chemical binding]; other site 481743011850 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 481743011851 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 481743011852 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 481743011853 PYR/PP interface [polypeptide binding]; other site 481743011854 dimer interface [polypeptide binding]; other site 481743011855 TPP binding site [chemical binding]; other site 481743011856 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 481743011857 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 481743011858 TPP-binding site; other site 481743011859 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 481743011860 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743011861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743011862 dimer interface [polypeptide binding]; other site 481743011863 ABC-ATPase subunit interface; other site 481743011864 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743011865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743011866 dimer interface [polypeptide binding]; other site 481743011867 conserved gate region; other site 481743011868 putative PBP binding loops; other site 481743011869 ABC-ATPase subunit interface; other site 481743011870 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743011871 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743011872 Helix-turn-helix domain; Region: HTH_18; pfam12833 481743011873 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743011874 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743011875 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743011876 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743011877 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743011878 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743011879 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743011880 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743011881 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 481743011882 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 481743011883 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 481743011884 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 481743011885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743011886 NAD(P) binding site [chemical binding]; other site 481743011887 active site 481743011888 Cache domain; Region: Cache_1; pfam02743 481743011889 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743011890 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743011891 dimerization interface [polypeptide binding]; other site 481743011892 Histidine kinase; Region: His_kinase; pfam06580 481743011893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743011894 ATP binding site [chemical binding]; other site 481743011895 Mg2+ binding site [ion binding]; other site 481743011896 G-X-G motif; other site 481743011897 Response regulator receiver domain; Region: Response_reg; pfam00072 481743011898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743011899 active site 481743011900 phosphorylation site [posttranslational modification] 481743011901 intermolecular recognition site; other site 481743011902 dimerization interface [polypeptide binding]; other site 481743011903 Helix-turn-helix domain; Region: HTH_18; pfam12833 481743011904 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743011905 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743011906 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743011907 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743011908 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743011909 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743011910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743011911 dimer interface [polypeptide binding]; other site 481743011912 conserved gate region; other site 481743011913 putative PBP binding loops; other site 481743011914 ABC-ATPase subunit interface; other site 481743011915 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743011916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743011917 dimer interface [polypeptide binding]; other site 481743011918 conserved gate region; other site 481743011919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 481743011920 ABC-ATPase subunit interface; other site 481743011921 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 481743011922 active site 1 [active] 481743011923 dimer interface [polypeptide binding]; other site 481743011924 hexamer interface [polypeptide binding]; other site 481743011925 active site 2 [active] 481743011926 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 481743011927 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743011928 dimerization interface [polypeptide binding]; other site 481743011929 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743011930 dimer interface [polypeptide binding]; other site 481743011931 phosphorylation site [posttranslational modification] 481743011932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743011933 ATP binding site [chemical binding]; other site 481743011934 Mg2+ binding site [ion binding]; other site 481743011935 G-X-G motif; other site 481743011936 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743011937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743011938 active site 481743011939 phosphorylation site [posttranslational modification] 481743011940 intermolecular recognition site; other site 481743011941 dimerization interface [polypeptide binding]; other site 481743011942 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743011943 DNA binding site [nucleotide binding] 481743011944 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 481743011945 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 481743011946 Metal-binding active site; metal-binding site 481743011947 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743011948 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743011949 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 481743011950 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481743011951 TM-ABC transporter signature motif; other site 481743011952 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 481743011953 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 481743011954 Walker A/P-loop; other site 481743011955 ATP binding site [chemical binding]; other site 481743011956 Q-loop/lid; other site 481743011957 ABC transporter signature motif; other site 481743011958 Walker B; other site 481743011959 D-loop; other site 481743011960 H-loop/switch region; other site 481743011961 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 481743011962 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 481743011963 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 481743011964 ligand binding site [chemical binding]; other site 481743011965 calcium binding site [ion binding]; other site 481743011966 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 481743011967 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 481743011968 ligand binding site [chemical binding]; other site 481743011969 Cache domain; Region: Cache_1; pfam02743 481743011970 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743011971 dimerization interface [polypeptide binding]; other site 481743011972 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743011973 Histidine kinase; Region: His_kinase; pfam06580 481743011974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743011975 ATP binding site [chemical binding]; other site 481743011976 Mg2+ binding site [ion binding]; other site 481743011977 G-X-G motif; other site 481743011978 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 481743011979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743011980 active site 481743011981 phosphorylation site [posttranslational modification] 481743011982 intermolecular recognition site; other site 481743011983 dimerization interface [polypeptide binding]; other site 481743011984 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743011985 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 481743011986 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 481743011987 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 481743011988 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 481743011989 ATP-grasp domain; Region: ATP-grasp; pfam02222 481743011990 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743011991 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743011992 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 481743011993 dimerization interface [polypeptide binding]; other site 481743011994 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 481743011995 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 481743011996 dimer interface [polypeptide binding]; other site 481743011997 active site 481743011998 catalytic residue [active] 481743011999 PAS fold; Region: PAS_4; pfam08448 481743012000 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481743012001 putative active site [active] 481743012002 heme pocket [chemical binding]; other site 481743012003 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 481743012004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743012005 dimer interface [polypeptide binding]; other site 481743012006 phosphorylation site [posttranslational modification] 481743012007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743012008 ATP binding site [chemical binding]; other site 481743012009 Mg2+ binding site [ion binding]; other site 481743012010 G-X-G motif; other site 481743012011 Uncharacterized conserved protein [Function unknown]; Region: COG1434 481743012012 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 481743012013 putative active site [active] 481743012014 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 481743012015 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 481743012016 hypothetical protein; Provisional; Region: PRK12378 481743012017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743012018 H+ Antiporter protein; Region: 2A0121; TIGR00900 481743012019 putative substrate translocation pore; other site 481743012020 sulfite reductase subunit beta; Provisional; Region: PRK13504 481743012021 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 481743012022 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 481743012023 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 481743012024 Flavodoxin; Region: Flavodoxin_1; pfam00258 481743012025 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 481743012026 FAD binding pocket [chemical binding]; other site 481743012027 FAD binding motif [chemical binding]; other site 481743012028 catalytic residues [active] 481743012029 NAD binding pocket [chemical binding]; other site 481743012030 phosphate binding motif [ion binding]; other site 481743012031 beta-alpha-beta structure motif; other site 481743012032 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 481743012033 Uncharacterized conserved protein [Function unknown]; Region: COG1624 481743012034 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 481743012035 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 481743012036 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 481743012037 Uncharacterized conserved protein [Function unknown]; Region: COG1683 481743012038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743012039 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743012040 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743012041 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743012042 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743012043 Cupin domain; Region: Cupin_2; pfam07883 481743012044 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743012045 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743012046 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743012047 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743012048 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743012049 metal-dependent hydrolase; Provisional; Region: PRK13291 481743012050 DinB superfamily; Region: DinB_2; pfam12867 481743012051 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481743012052 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481743012053 active site 481743012054 catalytic tetrad [active] 481743012055 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743012056 DNA-binding site [nucleotide binding]; DNA binding site 481743012057 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 481743012058 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743012059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743012060 homodimer interface [polypeptide binding]; other site 481743012061 catalytic residue [active] 481743012062 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 481743012063 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 481743012064 dimer interface [polypeptide binding]; other site 481743012065 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743012066 ligand binding site [chemical binding]; other site 481743012067 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 481743012068 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 481743012069 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 481743012070 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 481743012071 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 481743012072 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 481743012073 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 481743012074 active site 481743012075 Predicted membrane protein [Function unknown]; Region: COG1238 481743012076 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 481743012077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743012078 motif II; other site 481743012079 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 481743012080 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 481743012081 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743012082 motif II; other site 481743012083 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 481743012084 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 481743012085 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 481743012086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743012087 motif II; other site 481743012088 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 481743012089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743012090 Coenzyme A binding pocket [chemical binding]; other site 481743012091 Methyltransferase domain; Region: Methyltransf_23; pfam13489 481743012092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743012093 S-adenosylmethionine binding site [chemical binding]; other site 481743012094 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743012095 Coenzyme A binding pocket [chemical binding]; other site 481743012096 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743012097 Coenzyme A binding pocket [chemical binding]; other site 481743012098 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 481743012099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 481743012100 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 481743012101 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 481743012102 active site 481743012103 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 481743012104 trimer interface [polypeptide binding]; other site 481743012105 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743012106 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743012107 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 481743012108 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 481743012109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743012110 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 481743012111 Coenzyme A binding pocket [chemical binding]; other site 481743012112 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 481743012113 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 481743012114 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 481743012115 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 481743012116 Interdomain contacts; other site 481743012117 Cytokine receptor motif; other site 481743012118 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 481743012119 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 481743012120 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 481743012121 Interdomain contacts; other site 481743012122 Cytokine receptor motif; other site 481743012123 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 481743012124 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 481743012125 putative active site [active] 481743012126 AAA domain; Region: AAA_17; pfam13207 481743012127 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 481743012128 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 481743012129 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 481743012130 classical (c) SDRs; Region: SDR_c; cd05233 481743012131 NAD(P) binding site [chemical binding]; other site 481743012132 active site 481743012133 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743012134 Radical SAM superfamily; Region: Radical_SAM; pfam04055 481743012135 FeS/SAM binding site; other site 481743012136 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 481743012137 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 481743012138 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 481743012139 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 481743012140 DNA binding site [nucleotide binding] 481743012141 active site 481743012142 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 481743012143 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 481743012144 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743012145 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743012146 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 481743012147 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 481743012148 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 481743012149 minor groove reading motif; other site 481743012150 helix-hairpin-helix signature motif; other site 481743012151 substrate binding pocket [chemical binding]; other site 481743012152 active site 481743012153 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 481743012154 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 481743012155 Walker A motif; other site 481743012156 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 481743012157 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 481743012158 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 481743012159 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743012160 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743012161 DNA binding site [nucleotide binding] 481743012162 domain linker motif; other site 481743012163 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743012164 ligand binding site [chemical binding]; other site 481743012165 dimerization interface [polypeptide binding]; other site 481743012166 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 481743012167 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743012168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743012169 dimer interface [polypeptide binding]; other site 481743012170 conserved gate region; other site 481743012171 putative PBP binding loops; other site 481743012172 ABC-ATPase subunit interface; other site 481743012173 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 481743012174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743012175 dimer interface [polypeptide binding]; other site 481743012176 conserved gate region; other site 481743012177 putative PBP binding loops; other site 481743012178 ABC-ATPase subunit interface; other site 481743012179 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743012180 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 481743012181 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 481743012182 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 481743012183 ribulokinase; Provisional; Region: PRK04123 481743012184 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 481743012185 N- and C-terminal domain interface [polypeptide binding]; other site 481743012186 active site 481743012187 MgATP binding site [chemical binding]; other site 481743012188 catalytic site [active] 481743012189 metal binding site [ion binding]; metal-binding site 481743012190 carbohydrate binding site [chemical binding]; other site 481743012191 homodimer interface [polypeptide binding]; other site 481743012192 L-fucose isomerase; Provisional; Region: fucI; PRK10991 481743012193 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 481743012194 hexamer (dimer of trimers) interface [polypeptide binding]; other site 481743012195 trimer interface [polypeptide binding]; other site 481743012196 substrate binding site [chemical binding]; other site 481743012197 Mn binding site [ion binding]; other site 481743012198 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743012199 DNA binding site [nucleotide binding] 481743012200 domain linker motif; other site 481743012201 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 481743012202 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743012203 dimerization interface [polypeptide binding]; other site 481743012204 ligand binding site [chemical binding]; other site 481743012205 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 481743012206 conserved cys residue [active] 481743012207 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 481743012208 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 481743012209 NADP binding site [chemical binding]; other site 481743012210 homodimer interface [polypeptide binding]; other site 481743012211 active site 481743012212 Phosphotransferase enzyme family; Region: APH; pfam01636 481743012213 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743012214 substrate binding site [chemical binding]; other site 481743012215 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 481743012216 catalytic core [active] 481743012217 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 481743012218 dimer interface [polypeptide binding]; other site 481743012219 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743012220 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 481743012221 active site 481743012222 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 481743012223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 481743012224 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743012225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743012226 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 481743012227 classical (c) SDRs; Region: SDR_c; cd05233 481743012228 NAD(P) binding site [chemical binding]; other site 481743012229 active site 481743012230 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481743012231 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481743012232 active site 481743012233 catalytic tetrad [active] 481743012234 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 481743012235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743012236 putative substrate translocation pore; other site 481743012237 Predicted transcriptional regulators [Transcription]; Region: COG1733 481743012238 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 481743012239 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 481743012240 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 481743012241 intersubunit interface [polypeptide binding]; other site 481743012242 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743012243 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743012244 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 481743012245 Walker A/P-loop; other site 481743012246 ATP binding site [chemical binding]; other site 481743012247 Q-loop/lid; other site 481743012248 ABC transporter signature motif; other site 481743012249 Walker B; other site 481743012250 D-loop; other site 481743012251 H-loop/switch region; other site 481743012252 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 481743012253 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481743012254 ABC-ATPase subunit interface; other site 481743012255 dimer interface [polypeptide binding]; other site 481743012256 putative PBP binding regions; other site 481743012257 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 481743012258 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 481743012259 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481743012260 ABC-ATPase subunit interface; other site 481743012261 dimer interface [polypeptide binding]; other site 481743012262 putative PBP binding regions; other site 481743012263 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 481743012264 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 481743012265 putative Cl- selectivity filter; other site 481743012266 putative pore gating glutamate residue; other site 481743012267 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743012268 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481743012269 Walker A/P-loop; other site 481743012270 ATP binding site [chemical binding]; other site 481743012271 Q-loop/lid; other site 481743012272 ABC transporter signature motif; other site 481743012273 Walker B; other site 481743012274 D-loop; other site 481743012275 H-loop/switch region; other site 481743012276 Predicted transcriptional regulators [Transcription]; Region: COG1725 481743012277 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743012278 DNA-binding site [nucleotide binding]; DNA binding site 481743012279 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743012280 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 481743012281 Protease prsW family; Region: PrsW-protease; pfam13367 481743012282 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 481743012283 putative substrate binding pocket [chemical binding]; other site 481743012284 AC domain interface; other site 481743012285 catalytic triad [active] 481743012286 AB domain interface; other site 481743012287 interchain disulfide; other site 481743012288 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 481743012289 putative active site [active] 481743012290 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 481743012291 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 481743012292 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 481743012293 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 481743012294 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 481743012295 metal ion-dependent adhesion site (MIDAS); other site 481743012296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743012297 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 481743012298 Walker A motif; other site 481743012299 ATP binding site [chemical binding]; other site 481743012300 Walker B motif; other site 481743012301 arginine finger; other site 481743012302 HEAT repeats; Region: HEAT_2; pfam13646 481743012303 SWIM zinc finger; Region: SWIM; pfam04434 481743012304 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 481743012305 active site 481743012306 metal binding site [ion binding]; metal-binding site 481743012307 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743012308 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743012309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743012310 dimer interface [polypeptide binding]; other site 481743012311 conserved gate region; other site 481743012312 putative PBP binding loops; other site 481743012313 ABC-ATPase subunit interface; other site 481743012314 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743012315 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743012316 dimer interface [polypeptide binding]; other site 481743012317 conserved gate region; other site 481743012318 putative PBP binding loops; other site 481743012319 ABC-ATPase subunit interface; other site 481743012320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743012321 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743012322 putative substrate translocation pore; other site 481743012323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743012324 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 481743012325 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 481743012326 DNA binding residues [nucleotide binding] 481743012327 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 481743012328 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 481743012329 Lamin Tail Domain; Region: LTD; pfam00932 481743012330 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 481743012331 putative active site [active] 481743012332 putative metal binding site [ion binding]; other site 481743012333 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 481743012334 Interdomain contacts; other site 481743012335 Cytokine receptor motif; other site 481743012336 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 481743012337 Interdomain contacts; other site 481743012338 Cytokine receptor motif; other site 481743012339 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 481743012340 S-layer homology domain; Region: SLH; pfam00395 481743012341 S-layer homology domain; Region: SLH; pfam00395 481743012342 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 481743012343 protoporphyrinogen oxidase; Provisional; Region: PRK12416 481743012344 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 481743012345 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 481743012346 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 481743012347 synthetase active site [active] 481743012348 NTP binding site [chemical binding]; other site 481743012349 metal binding site [ion binding]; metal-binding site 481743012350 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 481743012351 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743012352 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743012353 DNA binding residues [nucleotide binding] 481743012354 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 481743012355 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 481743012356 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 481743012357 active site 481743012358 non-prolyl cis peptide bond; other site 481743012359 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 481743012360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743012361 dimer interface [polypeptide binding]; other site 481743012362 conserved gate region; other site 481743012363 ABC-ATPase subunit interface; other site 481743012364 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 481743012365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743012366 dimer interface [polypeptide binding]; other site 481743012367 conserved gate region; other site 481743012368 putative PBP binding loops; other site 481743012369 ABC-ATPase subunit interface; other site 481743012370 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 481743012371 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481743012372 substrate binding pocket [chemical binding]; other site 481743012373 membrane-bound complex binding site; other site 481743012374 hinge residues; other site 481743012375 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 481743012376 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 481743012377 Walker A/P-loop; other site 481743012378 ATP binding site [chemical binding]; other site 481743012379 Q-loop/lid; other site 481743012380 ABC transporter signature motif; other site 481743012381 Walker B; other site 481743012382 D-loop; other site 481743012383 H-loop/switch region; other site 481743012384 thymidine kinase; Provisional; Region: PRK04296 481743012385 Uncharacterized conserved protein [Function unknown]; Region: COG1284 481743012386 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 481743012387 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 481743012388 Uncharacterized conserved protein [Function unknown]; Region: COG0398 481743012389 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 481743012390 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 481743012391 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743012392 Coenzyme A binding pocket [chemical binding]; other site 481743012393 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 481743012394 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 481743012395 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 481743012396 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 481743012397 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 481743012398 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 481743012399 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 481743012400 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 481743012401 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 481743012402 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 481743012403 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 481743012404 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 481743012405 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 481743012406 Uncharacterized conserved protein [Function unknown]; Region: COG4278 481743012407 Predicted transcriptional regulators [Transcription]; Region: COG1695 481743012408 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 481743012409 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743012410 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 481743012411 active site 481743012412 motif I; other site 481743012413 motif II; other site 481743012414 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743012415 motif II; other site 481743012416 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 481743012417 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 481743012418 active site turn [active] 481743012419 phosphorylation site [posttranslational modification] 481743012420 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 481743012421 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 481743012422 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 481743012423 substrate binding [chemical binding]; other site 481743012424 active site 481743012425 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 481743012426 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743012427 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743012428 DNA binding site [nucleotide binding] 481743012429 domain linker motif; other site 481743012430 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 481743012431 dimerization interface [polypeptide binding]; other site 481743012432 ligand binding site [chemical binding]; other site 481743012433 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 481743012434 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192 481743012435 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 481743012436 homodimer interface [polypeptide binding]; other site 481743012437 NADP binding site [chemical binding]; other site 481743012438 substrate binding site [chemical binding]; other site 481743012439 Predicted permeases [General function prediction only]; Region: COG0701 481743012440 TIGR03943 family protein; Region: TIGR03943 481743012441 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 481743012442 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 481743012443 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 481743012444 YolD-like protein; Region: YolD; pfam08863 481743012445 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481743012446 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743012447 putative DNA binding site [nucleotide binding]; other site 481743012448 putative Zn2+ binding site [ion binding]; other site 481743012449 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 481743012450 dimer interface [polypeptide binding]; other site 481743012451 FMN binding site [chemical binding]; other site 481743012452 Uncharacterized conserved protein [Function unknown]; Region: COG1359 481743012453 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 481743012454 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 481743012455 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 481743012456 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 481743012457 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743012458 dimerization interface [polypeptide binding]; other site 481743012459 putative DNA binding site [nucleotide binding]; other site 481743012460 putative Zn2+ binding site [ion binding]; other site 481743012461 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 481743012462 putative hydrophobic ligand binding site [chemical binding]; other site 481743012463 Predicted transcriptional regulators [Transcription]; Region: COG1733 481743012464 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 481743012465 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 481743012466 tetramer interface [polypeptide binding]; other site 481743012467 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 481743012468 active site 481743012469 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 481743012470 active site 481743012471 dimer interface [polypeptide binding]; other site 481743012472 magnesium binding site [ion binding]; other site 481743012473 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 481743012474 AAA domain; Region: AAA_18; pfam13238 481743012475 active site 481743012476 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 481743012477 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 481743012478 putative ligand binding site [chemical binding]; other site 481743012479 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481743012480 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 481743012481 TM-ABC transporter signature motif; other site 481743012482 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 481743012483 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 481743012484 Walker A/P-loop; other site 481743012485 ATP binding site [chemical binding]; other site 481743012486 Q-loop/lid; other site 481743012487 ABC transporter signature motif; other site 481743012488 Walker B; other site 481743012489 D-loop; other site 481743012490 H-loop/switch region; other site 481743012491 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 481743012492 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 481743012493 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 481743012494 putative ligand binding site [chemical binding]; other site 481743012495 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743012496 Cache domain; Region: Cache_1; pfam02743 481743012497 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743012498 dimerization interface [polypeptide binding]; other site 481743012499 Histidine kinase; Region: His_kinase; pfam06580 481743012500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743012501 ATP binding site [chemical binding]; other site 481743012502 Mg2+ binding site [ion binding]; other site 481743012503 G-X-G motif; other site 481743012504 Response regulator receiver domain; Region: Response_reg; pfam00072 481743012505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743012506 active site 481743012507 phosphorylation site [posttranslational modification] 481743012508 intermolecular recognition site; other site 481743012509 dimerization interface [polypeptide binding]; other site 481743012510 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743012511 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743012512 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 481743012513 Predicted flavoprotein [General function prediction only]; Region: COG0431 481743012514 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 481743012515 active site 481743012516 Predicted flavoprotein [General function prediction only]; Region: COG0431 481743012517 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 481743012518 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743012519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743012520 active site 481743012521 phosphorylation site [posttranslational modification] 481743012522 intermolecular recognition site; other site 481743012523 dimerization interface [polypeptide binding]; other site 481743012524 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 481743012525 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743012526 DNA binding residues [nucleotide binding] 481743012527 dimerization interface [polypeptide binding]; other site 481743012528 GAF domain; Region: GAF_3; pfam13492 481743012529 GAF domain; Region: GAF_2; pfam13185 481743012530 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 481743012531 GAF domain; Region: GAF; cl17456 481743012532 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743012533 Histidine kinase; Region: HisKA_3; pfam07730 481743012534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743012535 ATP binding site [chemical binding]; other site 481743012536 Mg2+ binding site [ion binding]; other site 481743012537 G-X-G motif; other site 481743012538 Mor transcription activator family; Region: Mor; cl02360 481743012539 amidase; Provisional; Region: PRK06828 481743012540 Amidase; Region: Amidase; cl11426 481743012541 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743012542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743012543 Walker A/P-loop; other site 481743012544 ATP binding site [chemical binding]; other site 481743012545 Q-loop/lid; other site 481743012546 ABC transporter signature motif; other site 481743012547 Walker B; other site 481743012548 D-loop; other site 481743012549 H-loop/switch region; other site 481743012550 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 481743012551 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 481743012552 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 481743012553 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 481743012554 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 481743012555 inhibitor binding site; inhibition site 481743012556 active site 481743012557 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743012558 Cupin domain; Region: Cupin_2; cl17218 481743012559 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743012560 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743012561 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 481743012562 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 481743012563 putative active site [active] 481743012564 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 481743012565 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743012566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743012567 dimer interface [polypeptide binding]; other site 481743012568 phosphorylation site [posttranslational modification] 481743012569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743012570 ATP binding site [chemical binding]; other site 481743012571 Mg2+ binding site [ion binding]; other site 481743012572 G-X-G motif; other site 481743012573 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743012574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743012575 active site 481743012576 phosphorylation site [posttranslational modification] 481743012577 intermolecular recognition site; other site 481743012578 dimerization interface [polypeptide binding]; other site 481743012579 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743012580 DNA binding site [nucleotide binding] 481743012581 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743012582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743012583 Walker A/P-loop; other site 481743012584 ATP binding site [chemical binding]; other site 481743012585 Q-loop/lid; other site 481743012586 ABC transporter signature motif; other site 481743012587 Walker B; other site 481743012588 D-loop; other site 481743012589 H-loop/switch region; other site 481743012590 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 481743012591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 481743012592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 481743012593 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 481743012594 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 481743012595 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 481743012596 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 481743012597 N- and C-terminal domain interface [polypeptide binding]; other site 481743012598 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 481743012599 active site 481743012600 putative catalytic site [active] 481743012601 metal binding site [ion binding]; metal-binding site 481743012602 ATP binding site [chemical binding]; other site 481743012603 carbohydrate binding site [chemical binding]; other site 481743012604 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 481743012605 intersubunit interface [polypeptide binding]; other site 481743012606 active site 481743012607 Zn2+ binding site [ion binding]; other site 481743012608 L-fucose isomerase; Provisional; Region: fucI; PRK10991 481743012609 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 481743012610 hexamer (dimer of trimers) interface [polypeptide binding]; other site 481743012611 trimer interface [polypeptide binding]; other site 481743012612 substrate binding site [chemical binding]; other site 481743012613 Mn binding site [ion binding]; other site 481743012614 Cupin domain; Region: Cupin_2; pfam07883 481743012615 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743012616 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743012617 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743012618 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 481743012619 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 481743012620 catalytic loop [active] 481743012621 iron binding site [ion binding]; other site 481743012622 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743012623 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 481743012624 active site 481743012625 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 481743012626 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 481743012627 NlpC/P60 family; Region: NLPC_P60; pfam00877 481743012628 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 481743012629 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 481743012630 nucleotide binding site [chemical binding]; other site 481743012631 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 481743012632 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 481743012633 interface (dimer of trimers) [polypeptide binding]; other site 481743012634 Substrate-binding/catalytic site; other site 481743012635 Zn-binding sites [ion binding]; other site 481743012636 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 481743012637 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743012638 Walker A/P-loop; other site 481743012639 ATP binding site [chemical binding]; other site 481743012640 Q-loop/lid; other site 481743012641 ABC transporter signature motif; other site 481743012642 Walker B; other site 481743012643 D-loop; other site 481743012644 H-loop/switch region; other site 481743012645 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 481743012646 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 481743012647 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743012648 Walker A/P-loop; other site 481743012649 ATP binding site [chemical binding]; other site 481743012650 Q-loop/lid; other site 481743012651 ABC transporter signature motif; other site 481743012652 Walker B; other site 481743012653 D-loop; other site 481743012654 H-loop/switch region; other site 481743012655 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 481743012656 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 481743012657 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 481743012658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743012659 dimer interface [polypeptide binding]; other site 481743012660 conserved gate region; other site 481743012661 ABC-ATPase subunit interface; other site 481743012662 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 481743012663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743012664 dimer interface [polypeptide binding]; other site 481743012665 conserved gate region; other site 481743012666 putative PBP binding loops; other site 481743012667 ABC-ATPase subunit interface; other site 481743012668 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 481743012669 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 481743012670 L-asparaginase II; Region: Asparaginase_II; pfam06089 481743012671 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 481743012672 non-specific DNA interactions [nucleotide binding]; other site 481743012673 DNA binding site [nucleotide binding] 481743012674 sequence specific DNA binding site [nucleotide binding]; other site 481743012675 putative cAMP binding site [chemical binding]; other site 481743012676 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 481743012677 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 481743012678 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 481743012679 4Fe-4S binding domain; Region: Fer4; cl02805 481743012680 Predicted transcriptional regulator [Transcription]; Region: COG2345 481743012681 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743012682 putative DNA binding site [nucleotide binding]; other site 481743012683 putative Zn2+ binding site [ion binding]; other site 481743012684 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 481743012685 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 481743012686 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 481743012687 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 481743012688 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 481743012689 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 481743012690 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 481743012691 short chain dehydrogenase; Provisional; Region: PRK07677 481743012692 NAD(P) binding site [chemical binding]; other site 481743012693 substrate binding site [chemical binding]; other site 481743012694 homotetramer interface [polypeptide binding]; other site 481743012695 active site 481743012696 homodimer interface [polypeptide binding]; other site 481743012697 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 481743012698 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 481743012699 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 481743012700 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 481743012701 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 481743012702 Cysteine-rich domain; Region: CCG; pfam02754 481743012703 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 481743012704 Cysteine-rich domain; Region: CCG; pfam02754 481743012705 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 481743012706 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 481743012707 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 481743012708 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 481743012709 N- and C-terminal domain interface [polypeptide binding]; other site 481743012710 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 481743012711 active site 481743012712 putative catalytic site [active] 481743012713 metal binding site [ion binding]; metal-binding site 481743012714 ATP binding site [chemical binding]; other site 481743012715 carbohydrate binding site [chemical binding]; other site 481743012716 L-rhamnose isomerase; Provisional; Region: PRK01076 481743012717 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 481743012718 short chain dehydrogenase; Validated; Region: PRK08324 481743012719 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 481743012720 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 481743012721 putative NAD(P) binding site [chemical binding]; other site 481743012722 active site 481743012723 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 481743012724 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 481743012725 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 481743012726 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 481743012727 catalytic residues [active] 481743012728 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 481743012729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743012730 Coenzyme A binding pocket [chemical binding]; other site 481743012731 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 481743012732 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 481743012733 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 481743012734 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743012735 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743012736 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 481743012737 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743012738 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743012739 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743012740 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743012741 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743012742 DNA binding site [nucleotide binding] 481743012743 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743012744 dimerization interface [polypeptide binding]; other site 481743012745 ligand binding site [chemical binding]; other site 481743012746 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 481743012747 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 481743012748 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 481743012749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743012750 putative substrate translocation pore; other site 481743012751 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 481743012752 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 481743012753 Cupin domain; Region: Cupin_2; pfam07883 481743012754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743012755 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743012756 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743012757 DoxX; Region: DoxX; cl17842 481743012758 H+ Antiporter protein; Region: 2A0121; TIGR00900 481743012759 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 481743012760 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 481743012761 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 481743012762 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 481743012763 Walker A/P-loop; other site 481743012764 ATP binding site [chemical binding]; other site 481743012765 Q-loop/lid; other site 481743012766 ABC transporter signature motif; other site 481743012767 Walker B; other site 481743012768 D-loop; other site 481743012769 H-loop/switch region; other site 481743012770 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 481743012771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743012772 dimer interface [polypeptide binding]; other site 481743012773 conserved gate region; other site 481743012774 putative PBP binding loops; other site 481743012775 ABC-ATPase subunit interface; other site 481743012776 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 481743012777 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481743012778 substrate binding pocket [chemical binding]; other site 481743012779 membrane-bound complex binding site; other site 481743012780 hinge residues; other site 481743012781 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 481743012782 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 481743012783 DHHA2 domain; Region: DHHA2; pfam02833 481743012784 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 481743012785 FAD binding domain; Region: FAD_binding_4; pfam01565 481743012786 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 481743012787 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 481743012788 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 481743012789 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743012790 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 481743012791 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743012792 DNA binding residues [nucleotide binding] 481743012793 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 481743012794 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 481743012795 EDD domain protein, DegV family; Region: DegV; TIGR00762 481743012796 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 481743012797 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 481743012798 GIY-YIG motif/motif A; other site 481743012799 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 481743012800 DNA binding residues [nucleotide binding] 481743012801 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 481743012802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743012803 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743012804 putative substrate translocation pore; other site 481743012805 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 481743012806 DoxX-like family; Region: DoxX_3; pfam13781 481743012807 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743012808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743012809 active site 481743012810 phosphorylation site [posttranslational modification] 481743012811 intermolecular recognition site; other site 481743012812 dimerization interface [polypeptide binding]; other site 481743012813 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 481743012814 DNA binding residues [nucleotide binding] 481743012815 dimerization interface [polypeptide binding]; other site 481743012816 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743012817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743012818 ATP binding site [chemical binding]; other site 481743012819 Mg2+ binding site [ion binding]; other site 481743012820 G-X-G motif; other site 481743012821 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 481743012822 putative metal binding residues [ion binding]; other site 481743012823 signature motif; other site 481743012824 dimer interface [polypeptide binding]; other site 481743012825 active site 481743012826 polyP binding site; other site 481743012827 substrate binding site [chemical binding]; other site 481743012828 acceptor-phosphate pocket; other site 481743012829 ATP-dependent protease Lon; Provisional; Region: PRK13765 481743012830 CotH protein; Region: CotH; pfam08757 481743012831 Protein of unknown function (DUF3271); Region: DUF3271; pfam11675 481743012832 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 481743012833 Uncharacterized conserved protein [Function unknown]; Region: COG0398 481743012834 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 481743012835 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 481743012836 DinB superfamily; Region: DinB_2; pfam12867 481743012837 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 481743012838 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743012839 Coenzyme A binding pocket [chemical binding]; other site 481743012840 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 481743012841 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 481743012842 catalytic residues [active] 481743012843 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 481743012844 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 481743012845 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 481743012846 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 481743012847 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743012848 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 481743012849 Coenzyme A binding pocket [chemical binding]; other site 481743012850 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 481743012851 homotrimer interaction site [polypeptide binding]; other site 481743012852 putative active site [active] 481743012853 S-layer homology domain; Region: SLH; pfam00395 481743012854 S-layer homology domain; Region: SLH; pfam00395 481743012855 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 481743012856 active site 481743012857 pullulanase, type I; Region: pulA_typeI; TIGR02104 481743012858 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 481743012859 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 481743012860 Ca binding site [ion binding]; other site 481743012861 active site 481743012862 catalytic site [active] 481743012863 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 481743012864 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 481743012865 Protein of unknown function DUF58; Region: DUF58; pfam01882 481743012866 MoxR-like ATPases [General function prediction only]; Region: COG0714 481743012867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743012868 Walker A motif; other site 481743012869 ATP binding site [chemical binding]; other site 481743012870 Walker B motif; other site 481743012871 arginine finger; other site 481743012872 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 481743012873 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 481743012874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 481743012875 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 481743012876 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 481743012877 Chromate transporter; Region: Chromate_transp; pfam02417 481743012878 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 481743012879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743012880 putative substrate translocation pore; other site 481743012881 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481743012882 non-specific DNA binding site [nucleotide binding]; other site 481743012883 sequence-specific DNA binding site [nucleotide binding]; other site 481743012884 salt bridge; other site 481743012885 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481743012886 non-specific DNA binding site [nucleotide binding]; other site 481743012887 salt bridge; other site 481743012888 sequence-specific DNA binding site [nucleotide binding]; other site 481743012889 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 481743012890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743012891 Walker A/P-loop; other site 481743012892 ATP binding site [chemical binding]; other site 481743012893 Q-loop/lid; other site 481743012894 ABC transporter signature motif; other site 481743012895 Walker B; other site 481743012896 D-loop; other site 481743012897 H-loop/switch region; other site 481743012898 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481743012899 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 481743012900 TM-ABC transporter signature motif; other site 481743012901 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 481743012902 zinc binding site [ion binding]; other site 481743012903 putative ligand binding site [chemical binding]; other site 481743012904 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 481743012905 active site 481743012906 catalytic triad [active] 481743012907 oxyanion hole [active] 481743012908 hypothetical protein; Validated; Region: PRK01415 481743012909 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 481743012910 active site residue [active] 481743012911 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 481743012912 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 481743012913 classical (c) SDRs; Region: SDR_c; cd05233 481743012914 NAD(P) binding site [chemical binding]; other site 481743012915 active site 481743012916 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 481743012917 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 481743012918 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 481743012919 E3 interaction surface; other site 481743012920 lipoyl attachment site [posttranslational modification]; other site 481743012921 e3 binding domain; Region: E3_binding; pfam02817 481743012922 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 481743012923 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 481743012924 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 481743012925 TPP-binding site [chemical binding]; other site 481743012926 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 481743012927 Protein of unknown function DUF72; Region: DUF72; pfam01904 481743012928 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 481743012929 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 481743012930 active site 481743012931 metal binding site [ion binding]; metal-binding site 481743012932 homotetramer interface [polypeptide binding]; other site 481743012933 LysE type translocator; Region: LysE; pfam01810 481743012934 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 481743012935 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 481743012936 Na binding site [ion binding]; other site 481743012937 Spore germination protein; Region: Spore_permease; cl17796 481743012938 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 481743012939 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 481743012940 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 481743012941 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 481743012942 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 481743012943 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 481743012944 active site turn [active] 481743012945 phosphorylation site [posttranslational modification] 481743012946 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 481743012947 HPr interaction site; other site 481743012948 glycerol kinase (GK) interaction site [polypeptide binding]; other site 481743012949 active site 481743012950 phosphorylation site [posttranslational modification] 481743012951 PRD domain; Region: PRD; pfam00874 481743012952 PRD domain; Region: PRD; pfam00874 481743012953 CHASE3 domain; Region: CHASE3; pfam05227 481743012954 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743012955 dimerization interface [polypeptide binding]; other site 481743012956 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 481743012957 GAF domain; Region: GAF; pfam01590 481743012958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743012959 dimer interface [polypeptide binding]; other site 481743012960 phosphorylation site [posttranslational modification] 481743012961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743012962 ATP binding site [chemical binding]; other site 481743012963 Mg2+ binding site [ion binding]; other site 481743012964 G-X-G motif; other site 481743012965 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 481743012966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743012967 active site 481743012968 phosphorylation site [posttranslational modification] 481743012969 intermolecular recognition site; other site 481743012970 dimerization interface [polypeptide binding]; other site 481743012971 Cupin domain; Region: Cupin_2; cl17218 481743012972 DivIVA protein; Region: DivIVA; pfam05103 481743012973 DivIVA domain; Region: DivI1A_domain; TIGR03544 481743012974 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 481743012975 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743012976 putative DNA binding site [nucleotide binding]; other site 481743012977 putative Zn2+ binding site [ion binding]; other site 481743012978 H+ Antiporter protein; Region: 2A0121; TIGR00900 481743012979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743012980 putative substrate translocation pore; other site 481743012981 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743012982 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743012983 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743012984 Replication terminator protein; Region: RTP; pfam02334 481743012985 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 481743012986 Acyltransferase family; Region: Acyl_transf_3; pfam01757 481743012987 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 481743012988 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481743012989 ATP binding site [chemical binding]; other site 481743012990 putative Mg++ binding site [ion binding]; other site 481743012991 nucleotide binding region [chemical binding]; other site 481743012992 helicase superfamily c-terminal domain; Region: HELICc; smart00490 481743012993 Helicase associated domain (HA2); Region: HA2; pfam04408 481743012994 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 481743012995 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 481743012996 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 481743012997 active site 481743012998 HIGH motif; other site 481743012999 nucleotide binding site [chemical binding]; other site 481743013000 active site 481743013001 KMSKS motif; other site 481743013002 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 481743013003 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 481743013004 classical (c) SDRs; Region: SDR_c; cd05233 481743013005 NAD(P) binding site [chemical binding]; other site 481743013006 active site 481743013007 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 481743013008 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743013009 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481743013010 Walker A/P-loop; other site 481743013011 ATP binding site [chemical binding]; other site 481743013012 Q-loop/lid; other site 481743013013 ABC transporter signature motif; other site 481743013014 Walker B; other site 481743013015 D-loop; other site 481743013016 H-loop/switch region; other site 481743013017 Predicted transcriptional regulators [Transcription]; Region: COG1725 481743013018 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743013019 DNA-binding site [nucleotide binding]; DNA binding site 481743013020 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 481743013021 active site 481743013022 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 481743013023 metal ion-dependent adhesion site (MIDAS); other site 481743013024 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 481743013025 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743013026 active site 481743013027 ATP binding site [chemical binding]; other site 481743013028 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 481743013029 Proteins of 100 residues with WXG; Region: WXG100; cl02005 481743013030 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 481743013031 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 481743013032 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 481743013033 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 481743013034 Predicted transcriptional regulators [Transcription]; Region: COG1695 481743013035 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 481743013036 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 481743013037 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 481743013038 azoreductase; Provisional; Region: PRK13556 481743013039 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 481743013040 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 481743013041 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 481743013042 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 481743013043 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481743013044 Predicted membrane protein [Function unknown]; Region: COG2707 481743013045 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 481743013046 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 481743013047 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 481743013048 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 481743013049 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743013050 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743013051 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 481743013052 Walker A/P-loop; other site 481743013053 ATP binding site [chemical binding]; other site 481743013054 Q-loop/lid; other site 481743013055 ABC transporter signature motif; other site 481743013056 Walker B; other site 481743013057 D-loop; other site 481743013058 H-loop/switch region; other site 481743013059 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 481743013060 nudix motif; other site 481743013061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 481743013062 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743013063 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 481743013064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743013065 Walker A/P-loop; other site 481743013066 ATP binding site [chemical binding]; other site 481743013067 Q-loop/lid; other site 481743013068 ABC transporter signature motif; other site 481743013069 Walker B; other site 481743013070 D-loop; other site 481743013071 H-loop/switch region; other site 481743013072 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743013073 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743013074 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 481743013075 Walker A/P-loop; other site 481743013076 ATP binding site [chemical binding]; other site 481743013077 Q-loop/lid; other site 481743013078 ABC transporter signature motif; other site 481743013079 Walker B; other site 481743013080 D-loop; other site 481743013081 H-loop/switch region; other site 481743013082 PrcB C-terminal; Region: PrcB_C; pfam14343 481743013083 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 481743013084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743013085 Walker A/P-loop; other site 481743013086 ATP binding site [chemical binding]; other site 481743013087 Q-loop/lid; other site 481743013088 ABC transporter signature motif; other site 481743013089 Walker B; other site 481743013090 D-loop; other site 481743013091 H-loop/switch region; other site 481743013092 MarR family; Region: MarR_2; cl17246 481743013093 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 481743013094 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 481743013095 nucleotide binding site [chemical binding]; other site 481743013096 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 481743013097 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 481743013098 dimerization interface [polypeptide binding]; other site 481743013099 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 481743013100 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 481743013101 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 481743013102 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 481743013103 MPT binding site; other site 481743013104 trimer interface [polypeptide binding]; other site 481743013105 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 481743013106 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 481743013107 putative NADP binding site [chemical binding]; other site 481743013108 putative dimer interface [polypeptide binding]; other site 481743013109 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 481743013110 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 481743013111 active site 481743013112 Isochorismatase family; Region: Isochorismatase; pfam00857 481743013113 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 481743013114 catalytic triad [active] 481743013115 conserved cis-peptide bond; other site 481743013116 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 481743013117 nudix motif; other site 481743013118 Protein of unknown function (DUF964); Region: DUF964; cl01483 481743013119 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 481743013120 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 481743013121 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743013122 FeS/SAM binding site; other site 481743013123 TRAM domain; Region: TRAM; pfam01938 481743013124 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 481743013125 Propanediol utilisation protein PduL; Region: PduL; pfam06130 481743013126 Propanediol utilisation protein PduL; Region: PduL; pfam06130 481743013127 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 481743013128 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 481743013129 active site 481743013130 dimer interface [polypeptide binding]; other site 481743013131 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 481743013132 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 481743013133 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 481743013134 putative active site [active] 481743013135 metal binding site [ion binding]; metal-binding site 481743013136 homodimer binding site [polypeptide binding]; other site 481743013137 phosphodiesterase; Provisional; Region: PRK12704 481743013138 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 481743013139 Zn2+ binding site [ion binding]; other site 481743013140 Mg2+ binding site [ion binding]; other site 481743013141 RecX family; Region: RecX; cl00936 481743013142 recombinase A; Provisional; Region: recA; PRK09354 481743013143 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 481743013144 hexamer interface [polypeptide binding]; other site 481743013145 Walker A motif; other site 481743013146 ATP binding site [chemical binding]; other site 481743013147 Walker B motif; other site 481743013148 competence damage-inducible protein A; Provisional; Region: PRK00549 481743013149 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 481743013150 putative MPT binding site; other site 481743013151 Competence-damaged protein; Region: CinA; pfam02464 481743013152 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 481743013153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 481743013154 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 481743013155 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 481743013156 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481743013157 non-specific DNA binding site [nucleotide binding]; other site 481743013158 salt bridge; other site 481743013159 sequence-specific DNA binding site [nucleotide binding]; other site 481743013160 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 481743013161 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 481743013162 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 481743013163 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 481743013164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743013165 NAD(P) binding site [chemical binding]; other site 481743013166 active site 481743013167 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 481743013168 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 481743013169 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 481743013170 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 481743013171 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 481743013172 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 481743013173 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 481743013174 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 481743013175 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 481743013176 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 481743013177 galactarate dehydratase; Region: galactar-dH20; TIGR03248 481743013178 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 481743013179 altronate oxidoreductase; Provisional; Region: PRK03643 481743013180 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 481743013181 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 481743013182 Glucuronate isomerase; Region: UxaC; pfam02614 481743013183 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 481743013184 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743013185 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743013186 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743013187 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743013188 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 481743013189 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 481743013190 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 481743013191 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 481743013192 YlzJ-like protein; Region: YlzJ; pfam14035 481743013193 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 481743013194 Clp protease; Region: CLP_protease; pfam00574 481743013195 active site 481743013196 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 481743013197 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 481743013198 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 481743013199 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 481743013200 dihydrodipicolinate synthase; Region: dapA; TIGR00674 481743013201 dimer interface [polypeptide binding]; other site 481743013202 active site 481743013203 catalytic residue [active] 481743013204 aspartate kinase I; Reviewed; Region: PRK08210 481743013205 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 481743013206 nucleotide binding site [chemical binding]; other site 481743013207 substrate binding site [chemical binding]; other site 481743013208 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 481743013209 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 481743013210 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 481743013211 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 481743013212 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 481743013213 NAD binding site [chemical binding]; other site 481743013214 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 481743013215 trimer interface [polypeptide binding]; other site 481743013216 active site 481743013217 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 481743013218 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 481743013219 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 481743013220 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 481743013221 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 481743013222 NodB motif; other site 481743013223 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 481743013224 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 481743013225 RNase E interface [polypeptide binding]; other site 481743013226 trimer interface [polypeptide binding]; other site 481743013227 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 481743013228 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 481743013229 RNase E interface [polypeptide binding]; other site 481743013230 trimer interface [polypeptide binding]; other site 481743013231 active site 481743013232 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 481743013233 putative nucleic acid binding region [nucleotide binding]; other site 481743013234 G-X-X-G motif; other site 481743013235 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 481743013236 RNA binding site [nucleotide binding]; other site 481743013237 domain interface; other site 481743013238 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 481743013239 16S/18S rRNA binding site [nucleotide binding]; other site 481743013240 S13e-L30e interaction site [polypeptide binding]; other site 481743013241 25S rRNA binding site [nucleotide binding]; other site 481743013242 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 481743013243 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 481743013244 active site 481743013245 Riboflavin kinase; Region: Flavokinase; smart00904 481743013246 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 481743013247 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 481743013248 RNA binding site [nucleotide binding]; other site 481743013249 active site 481743013250 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 481743013251 DHH family; Region: DHH; pfam01368 481743013252 DHHA1 domain; Region: DHHA1; pfam02272 481743013253 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 481743013254 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 481743013255 translation initiation factor IF-2; Region: IF-2; TIGR00487 481743013256 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 481743013257 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 481743013258 G1 box; other site 481743013259 putative GEF interaction site [polypeptide binding]; other site 481743013260 GTP/Mg2+ binding site [chemical binding]; other site 481743013261 Switch I region; other site 481743013262 G2 box; other site 481743013263 G3 box; other site 481743013264 Switch II region; other site 481743013265 G4 box; other site 481743013266 G5 box; other site 481743013267 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 481743013268 Translation-initiation factor 2; Region: IF-2; pfam11987 481743013269 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 481743013270 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 481743013271 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 481743013272 putative RNA binding cleft [nucleotide binding]; other site 481743013273 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 481743013274 NusA N-terminal domain; Region: NusA_N; pfam08529 481743013275 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 481743013276 RNA binding site [nucleotide binding]; other site 481743013277 homodimer interface [polypeptide binding]; other site 481743013278 NusA-like KH domain; Region: KH_5; pfam13184 481743013279 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 481743013280 G-X-X-G motif; other site 481743013281 Sm and related proteins; Region: Sm_like; cl00259 481743013282 ribosome maturation protein RimP; Reviewed; Region: PRK00092 481743013283 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 481743013284 putative oligomer interface [polypeptide binding]; other site 481743013285 putative RNA binding site [nucleotide binding]; other site 481743013286 DNA polymerase III PolC; Validated; Region: polC; PRK00448 481743013287 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 481743013288 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 481743013289 generic binding surface II; other site 481743013290 generic binding surface I; other site 481743013291 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 481743013292 active site 481743013293 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 481743013294 active site 481743013295 catalytic site [active] 481743013296 substrate binding site [chemical binding]; other site 481743013297 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 481743013298 putative PHP Thumb interface [polypeptide binding]; other site 481743013299 active site 481743013300 prolyl-tRNA synthetase; Provisional; Region: PRK08661 481743013301 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 481743013302 dimer interface [polypeptide binding]; other site 481743013303 motif 1; other site 481743013304 active site 481743013305 motif 2; other site 481743013306 motif 3; other site 481743013307 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 481743013308 anticodon binding site; other site 481743013309 zinc-binding site [ion binding]; other site 481743013310 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 481743013311 RIP metalloprotease RseP; Region: TIGR00054 481743013312 active site 481743013313 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 481743013314 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 481743013315 protein binding site [polypeptide binding]; other site 481743013316 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 481743013317 putative substrate binding region [chemical binding]; other site 481743013318 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 481743013319 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 481743013320 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 481743013321 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 481743013322 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 481743013323 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 481743013324 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 481743013325 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 481743013326 catalytic residue [active] 481743013327 putative FPP diphosphate binding site; other site 481743013328 putative FPP binding hydrophobic cleft; other site 481743013329 dimer interface [polypeptide binding]; other site 481743013330 putative IPP diphosphate binding site; other site 481743013331 ribosome recycling factor; Reviewed; Region: frr; PRK00083 481743013332 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 481743013333 hinge region; other site 481743013334 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 481743013335 putative nucleotide binding site [chemical binding]; other site 481743013336 uridine monophosphate binding site [chemical binding]; other site 481743013337 homohexameric interface [polypeptide binding]; other site 481743013338 elongation factor Ts; Reviewed; Region: tsf; PRK12332 481743013339 UBA/TS-N domain; Region: UBA; pfam00627 481743013340 Elongation factor TS; Region: EF_TS; pfam00889 481743013341 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 481743013342 rRNA interaction site [nucleotide binding]; other site 481743013343 S8 interaction site; other site 481743013344 putative laminin-1 binding site; other site 481743013345 malate dehydrogenase; Provisional; Region: PRK13529 481743013346 YceG-like family; Region: YceG; pfam02618 481743013347 Protein of unknown function (DUF342); Region: DUF342; pfam03961 481743013348 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 481743013349 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743013350 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 481743013351 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743013352 DNA binding residues [nucleotide binding] 481743013353 CheD chemotactic sensory transduction; Region: CheD; cl00810 481743013354 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 481743013355 CheC-like family; Region: CheC; pfam04509 481743013356 CheC-like family; Region: CheC; pfam04509 481743013357 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 481743013358 putative CheA interaction surface; other site 481743013359 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 481743013360 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 481743013361 putative binding surface; other site 481743013362 active site 481743013363 P2 response regulator binding domain; Region: P2; pfam07194 481743013364 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 481743013365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743013366 ATP binding site [chemical binding]; other site 481743013367 Mg2+ binding site [ion binding]; other site 481743013368 G-X-G motif; other site 481743013369 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 481743013370 Response regulator receiver domain; Region: Response_reg; pfam00072 481743013371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743013372 active site 481743013373 phosphorylation site [posttranslational modification] 481743013374 intermolecular recognition site; other site 481743013375 dimerization interface [polypeptide binding]; other site 481743013376 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 481743013377 CheB methylesterase; Region: CheB_methylest; pfam01339 481743013378 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 481743013379 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 481743013380 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 481743013381 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 481743013382 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 481743013383 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 481743013384 FHIPEP family; Region: FHIPEP; pfam00771 481743013385 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 481743013386 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 481743013387 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 481743013388 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 481743013389 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 481743013390 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 481743013391 Response regulator receiver domain; Region: Response_reg; pfam00072 481743013392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743013393 active site 481743013394 phosphorylation site [posttranslational modification] 481743013395 intermolecular recognition site; other site 481743013396 dimerization interface [polypeptide binding]; other site 481743013397 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 481743013398 CheC-like family; Region: CheC; pfam04509 481743013399 CheC-like family; Region: CheC; pfam04509 481743013400 flagellar motor switch protein FliN; Region: fliN; TIGR02480 481743013401 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 481743013402 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 481743013403 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 481743013404 Flagellar protein (FlbD); Region: FlbD; pfam06289 481743013405 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 481743013406 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 481743013407 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 481743013408 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 481743013409 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 481743013410 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 481743013411 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 481743013412 Uncharacterized conserved protein [Function unknown]; Region: COG3334 481743013413 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 481743013414 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 481743013415 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 481743013416 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 481743013417 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 481743013418 Walker A motif/ATP binding site; other site 481743013419 Walker B motif; other site 481743013420 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 481743013421 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 481743013422 Flagellar assembly protein FliH; Region: FliH; pfam02108 481743013423 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 481743013424 FliG C-terminal domain; Region: FliG_C; pfam01706 481743013425 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 481743013426 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 481743013427 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 481743013428 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 481743013429 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 481743013430 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 481743013431 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 481743013432 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 481743013433 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 481743013434 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 481743013435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743013436 Walker A motif; other site 481743013437 ATP binding site [chemical binding]; other site 481743013438 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 481743013439 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 481743013440 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 481743013441 active site 481743013442 HslU subunit interaction site [polypeptide binding]; other site 481743013443 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 481743013444 Glucose inhibited division protein A; Region: GIDA; pfam01134 481743013445 DNA topoisomerase I; Validated; Region: PRK05582 481743013446 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 481743013447 active site 481743013448 interdomain interaction site; other site 481743013449 putative metal-binding site [ion binding]; other site 481743013450 nucleotide binding site [chemical binding]; other site 481743013451 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 481743013452 domain I; other site 481743013453 DNA binding groove [nucleotide binding] 481743013454 phosphate binding site [ion binding]; other site 481743013455 domain II; other site 481743013456 domain III; other site 481743013457 nucleotide binding site [chemical binding]; other site 481743013458 catalytic site [active] 481743013459 domain IV; other site 481743013460 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 481743013461 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 481743013462 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 481743013463 DNA protecting protein DprA; Region: dprA; TIGR00732 481743013464 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 481743013465 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 481743013466 CoA binding domain; Region: CoA_binding; pfam02629 481743013467 CoA-ligase; Region: Ligase_CoA; pfam00549 481743013468 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 481743013469 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 481743013470 CoA-ligase; Region: Ligase_CoA; pfam00549 481743013471 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 481743013472 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743013473 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743013474 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743013475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743013476 dimer interface [polypeptide binding]; other site 481743013477 conserved gate region; other site 481743013478 putative PBP binding loops; other site 481743013479 ABC-ATPase subunit interface; other site 481743013480 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743013481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743013482 dimer interface [polypeptide binding]; other site 481743013483 conserved gate region; other site 481743013484 ABC-ATPase subunit interface; other site 481743013485 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743013486 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 481743013487 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743013488 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 481743013489 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 481743013490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743013491 Walker A motif; other site 481743013492 ATP binding site [chemical binding]; other site 481743013493 Walker B motif; other site 481743013494 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 481743013495 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 481743013496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743013497 Coenzyme A binding pocket [chemical binding]; other site 481743013498 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743013499 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 481743013500 active site 481743013501 hypothetical protein; Reviewed; Region: PRK12497 481743013502 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 481743013503 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 481743013504 RNA/DNA hybrid binding site [nucleotide binding]; other site 481743013505 active site 481743013506 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 481743013507 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 481743013508 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 481743013509 active site 481743013510 substrate binding [chemical binding]; other site 481743013511 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 481743013512 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 481743013513 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 481743013514 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 481743013515 putative sugar binding sites [chemical binding]; other site 481743013516 Q-X-W motif; other site 481743013517 Ricin-type beta-trefoil; Region: RICIN; smart00458 481743013518 Ricin-type beta-trefoil; Region: RICIN; smart00458 481743013519 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 481743013520 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 481743013521 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 481743013522 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 481743013523 substrate binding [chemical binding]; other site 481743013524 active site 481743013525 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 481743013526 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743013527 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743013528 CRISPR-associated protein, TIGR03984 family; Region: TIGR03984 481743013529 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743013530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743013531 ABC-ATPase subunit interface; other site 481743013532 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743013533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743013534 dimer interface [polypeptide binding]; other site 481743013535 conserved gate region; other site 481743013536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 481743013537 ABC-ATPase subunit interface; other site 481743013538 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743013539 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743013540 DNA binding site [nucleotide binding] 481743013541 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 481743013542 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 481743013543 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 481743013544 GTP/Mg2+ binding site [chemical binding]; other site 481743013545 G4 box; other site 481743013546 G5 box; other site 481743013547 G1 box; other site 481743013548 Switch I region; other site 481743013549 G2 box; other site 481743013550 G3 box; other site 481743013551 Switch II region; other site 481743013552 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 481743013553 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 481743013554 Catalytic site [active] 481743013555 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 481743013556 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 481743013557 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 481743013558 RimM N-terminal domain; Region: RimM; pfam01782 481743013559 PRC-barrel domain; Region: PRC; pfam05239 481743013560 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 481743013561 hypothetical protein; Provisional; Region: PRK00468 481743013562 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 481743013563 signal recognition particle protein; Provisional; Region: PRK10867 481743013564 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 481743013565 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 481743013566 P loop; other site 481743013567 GTP binding site [chemical binding]; other site 481743013568 Signal peptide binding domain; Region: SRP_SPB; pfam02978 481743013569 putative DNA-binding protein; Validated; Region: PRK00118 481743013570 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 481743013571 Haemolysin-III related; Region: HlyIII; cl03831 481743013572 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 481743013573 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 481743013574 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 481743013575 putative homodimer interface [polypeptide binding]; other site 481743013576 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 481743013577 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 481743013578 active site 481743013579 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 481743013580 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 481743013581 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 481743013582 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 481743013583 P loop; other site 481743013584 GTP binding site [chemical binding]; other site 481743013585 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 481743013586 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 481743013587 Walker A/P-loop; other site 481743013588 ATP binding site [chemical binding]; other site 481743013589 Q-loop/lid; other site 481743013590 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 481743013591 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 481743013592 ABC transporter signature motif; other site 481743013593 Walker B; other site 481743013594 D-loop; other site 481743013595 H-loop/switch region; other site 481743013596 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 481743013597 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 481743013598 dimerization interface [polypeptide binding]; other site 481743013599 active site 481743013600 metal binding site [ion binding]; metal-binding site 481743013601 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 481743013602 dsRNA binding site [nucleotide binding]; other site 481743013603 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 481743013604 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 481743013605 dimer interface [polypeptide binding]; other site 481743013606 active site 481743013607 acyl carrier protein; Provisional; Region: acpP; PRK00982 481743013608 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 481743013609 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 481743013610 NAD(P) binding site [chemical binding]; other site 481743013611 homotetramer interface [polypeptide binding]; other site 481743013612 homodimer interface [polypeptide binding]; other site 481743013613 active site 481743013614 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 481743013615 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 481743013616 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 481743013617 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 481743013618 dimer interface [polypeptide binding]; other site 481743013619 active site 481743013620 CoA binding pocket [chemical binding]; other site 481743013621 putative phosphate acyltransferase; Provisional; Region: PRK05331 481743013622 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 481743013623 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 481743013624 active site 2 [active] 481743013625 active site 1 [active] 481743013626 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 481743013627 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 481743013628 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 481743013629 hypothetical protein; Provisional; Region: PRK13670 481743013630 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 481743013631 PDZ domain; Region: PDZ_2; pfam13180 481743013632 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 481743013633 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 481743013634 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 481743013635 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 481743013636 active site 481743013637 (T/H)XGH motif; other site 481743013638 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 481743013639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743013640 S-adenosylmethionine binding site [chemical binding]; other site 481743013641 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743013642 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743013643 Helix-turn-helix domain; Region: HTH_28; pfam13518 481743013644 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743013645 binding surface 481743013646 TPR motif; other site 481743013647 Tetratricopeptide repeat; Region: TPR_12; pfam13424 481743013648 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 481743013649 active site 481743013650 catalytic triad [active] 481743013651 oxyanion hole [active] 481743013652 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743013653 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 481743013654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 481743013655 Coenzyme A binding pocket [chemical binding]; other site 481743013656 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481743013657 MarR family; Region: MarR; pfam01047 481743013658 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 481743013659 tetramer (dimer of dimers) interface [polypeptide binding]; other site 481743013660 active site 481743013661 dimer interface [polypeptide binding]; other site 481743013662 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 481743013663 putative active site [active] 481743013664 putative ADP-ribose binding site [chemical binding]; other site 481743013665 TraX protein; Region: TraX; cl05434 481743013666 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743013667 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743013668 DNA binding site [nucleotide binding] 481743013669 domain linker motif; other site 481743013670 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743013671 dimerization interface [polypeptide binding]; other site 481743013672 ligand binding site [chemical binding]; other site 481743013673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743013674 MFS/sugar transport protein; Region: MFS_2; pfam13347 481743013675 putative substrate translocation pore; other site 481743013676 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 481743013677 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 481743013678 active site 481743013679 catalytic site [active] 481743013680 metal binding site [ion binding]; metal-binding site 481743013681 dimer interface [polypeptide binding]; other site 481743013682 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481743013683 MarR family; Region: MarR_2; pfam12802 481743013684 MarR family; Region: MarR_2; cl17246 481743013685 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743013686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743013687 putative substrate translocation pore; other site 481743013688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743013689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743013690 putative substrate translocation pore; other site 481743013691 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 481743013692 CHASE3 domain; Region: CHASE3; cl05000 481743013693 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743013694 dimerization interface [polypeptide binding]; other site 481743013695 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 481743013696 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 481743013697 dimer interface [polypeptide binding]; other site 481743013698 putative CheW interface [polypeptide binding]; other site 481743013699 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 481743013700 Part of AAA domain; Region: AAA_19; pfam13245 481743013701 Family description; Region: UvrD_C_2; pfam13538 481743013702 Predicted membrane protein [Function unknown]; Region: COG4129 481743013703 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 481743013704 Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262 481743013705 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 481743013706 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 481743013707 active site 481743013708 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 481743013709 NADH(P)-binding; Region: NAD_binding_10; pfam13460 481743013710 NAD(P) binding site [chemical binding]; other site 481743013711 putative active site [active] 481743013712 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 481743013713 tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167 481743013714 active site residue [active] 481743013715 selenophosphate synthetase; Provisional; Region: PRK00943 481743013716 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 481743013717 dimerization interface [polypeptide binding]; other site 481743013718 putative ATP binding site [chemical binding]; other site 481743013719 Predicted permease; Region: DUF318; cl17795 481743013720 SurA N-terminal domain; Region: SurA_N_3; cl07813 481743013721 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 481743013722 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 481743013723 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 481743013724 active site 481743013725 catalytic residues [active] 481743013726 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 481743013727 glycerol kinase; Provisional; Region: glpK; PRK00047 481743013728 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 481743013729 N- and C-terminal domain interface [polypeptide binding]; other site 481743013730 active site 481743013731 MgATP binding site [chemical binding]; other site 481743013732 catalytic site [active] 481743013733 metal binding site [ion binding]; metal-binding site 481743013734 glycerol binding site [chemical binding]; other site 481743013735 homotetramer interface [polypeptide binding]; other site 481743013736 homodimer interface [polypeptide binding]; other site 481743013737 FBP binding site [chemical binding]; other site 481743013738 protein IIAGlc interface [polypeptide binding]; other site 481743013739 FeoC like transcriptional regulator; Region: FeoC; cl17677 481743013740 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 481743013741 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 481743013742 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743013743 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743013744 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743013745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743013746 dimer interface [polypeptide binding]; other site 481743013747 conserved gate region; other site 481743013748 putative PBP binding loops; other site 481743013749 ABC-ATPase subunit interface; other site 481743013750 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743013751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743013752 dimer interface [polypeptide binding]; other site 481743013753 conserved gate region; other site 481743013754 putative PBP binding loops; other site 481743013755 ABC-ATPase subunit interface; other site 481743013756 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743013757 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743013758 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743013759 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743013760 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743013761 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743013762 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743013763 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743013764 Putative oxidoreductase C terminal; Region: ox_reductase_C; pfam08635 481743013765 succinic semialdehyde dehydrogenase; Region: PLN02278 481743013766 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 481743013767 tetramerization interface [polypeptide binding]; other site 481743013768 NAD(P) binding site [chemical binding]; other site 481743013769 catalytic residues [active] 481743013770 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 481743013771 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 481743013772 putative ligand binding residues [chemical binding]; other site 481743013773 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 481743013774 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 481743013775 Walker A/P-loop; other site 481743013776 ATP binding site [chemical binding]; other site 481743013777 Q-loop/lid; other site 481743013778 ABC transporter signature motif; other site 481743013779 Walker B; other site 481743013780 D-loop; other site 481743013781 H-loop/switch region; other site 481743013782 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481743013783 ABC-ATPase subunit interface; other site 481743013784 dimer interface [polypeptide binding]; other site 481743013785 putative PBP binding regions; other site 481743013786 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 481743013787 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481743013788 ABC-ATPase subunit interface; other site 481743013789 dimer interface [polypeptide binding]; other site 481743013790 putative PBP binding regions; other site 481743013791 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 481743013792 dimer interface [polypeptide binding]; other site 481743013793 FMN binding site [chemical binding]; other site 481743013794 YKOF-related Family; Region: Ykof; pfam07615 481743013795 YKOF-related Family; Region: Ykof; pfam07615 481743013796 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 481743013797 active site 481743013798 NTP binding site [chemical binding]; other site 481743013799 metal binding triad [ion binding]; metal-binding site 481743013800 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 481743013801 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 481743013802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743013803 S-adenosylmethionine binding site [chemical binding]; other site 481743013804 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 481743013805 dimerization interface [polypeptide binding]; other site 481743013806 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 481743013807 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 481743013808 dimer interface [polypeptide binding]; other site 481743013809 putative CheW interface [polypeptide binding]; other site 481743013810 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 481743013811 catalytic core [active] 481743013812 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 481743013813 nudix motif; other site 481743013814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743013815 S-adenosylmethionine binding site [chemical binding]; other site 481743013816 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 481743013817 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 481743013818 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 481743013819 substrate binding site [chemical binding]; other site 481743013820 dimer interface [polypeptide binding]; other site 481743013821 ATP binding site [chemical binding]; other site 481743013822 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 481743013823 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 481743013824 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743013825 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743013826 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743013827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743013828 dimer interface [polypeptide binding]; other site 481743013829 conserved gate region; other site 481743013830 putative PBP binding loops; other site 481743013831 ABC-ATPase subunit interface; other site 481743013832 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743013833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743013834 dimer interface [polypeptide binding]; other site 481743013835 conserved gate region; other site 481743013836 putative PBP binding loops; other site 481743013837 ABC-ATPase subunit interface; other site 481743013838 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 481743013839 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 481743013840 Transcriptional regulators [Transcription]; Region: FadR; COG2186 481743013841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743013842 DNA-binding site [nucleotide binding]; DNA binding site 481743013843 FCD domain; Region: FCD; pfam07729 481743013844 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 481743013845 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 481743013846 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 481743013847 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743013848 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743013849 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743013850 Protein of unknown function (DUF664); Region: DUF664; pfam04978 481743013851 DinB superfamily; Region: DinB_2; pfam12867 481743013852 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 481743013853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743013854 Coenzyme A binding pocket [chemical binding]; other site 481743013855 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 481743013856 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 481743013857 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 481743013858 active site 481743013859 catalytic triad [active] 481743013860 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743013861 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 481743013862 Histidine kinase; Region: His_kinase; pfam06580 481743013863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743013864 ATP binding site [chemical binding]; other site 481743013865 Mg2+ binding site [ion binding]; other site 481743013866 G-X-G motif; other site 481743013867 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 481743013868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743013869 active site 481743013870 phosphorylation site [posttranslational modification] 481743013871 intermolecular recognition site; other site 481743013872 dimerization interface [polypeptide binding]; other site 481743013873 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743013874 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743013875 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743013876 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 481743013877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743013878 dimer interface [polypeptide binding]; other site 481743013879 conserved gate region; other site 481743013880 putative PBP binding loops; other site 481743013881 ABC-ATPase subunit interface; other site 481743013882 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743013883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743013884 dimer interface [polypeptide binding]; other site 481743013885 conserved gate region; other site 481743013886 putative PBP binding loops; other site 481743013887 ABC-ATPase subunit interface; other site 481743013888 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 481743013889 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 481743013890 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 481743013891 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 481743013892 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 481743013893 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 481743013894 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 481743013895 nudix motif; other site 481743013896 Ion channel; Region: Ion_trans_2; pfam07885 481743013897 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 481743013898 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 481743013899 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481743013900 ATP binding site [chemical binding]; other site 481743013901 putative Mg++ binding site [ion binding]; other site 481743013902 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 481743013903 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481743013904 nucleotide binding region [chemical binding]; other site 481743013905 ATP-binding site [chemical binding]; other site 481743013906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743013907 Coenzyme A binding pocket [chemical binding]; other site 481743013908 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 481743013909 TIGR01777 family protein; Region: yfcH 481743013910 putative NAD(P) binding site [chemical binding]; other site 481743013911 putative active site [active] 481743013912 Methyltransferase domain; Region: Methyltransf_23; pfam13489 481743013913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 481743013914 Phosphotransferase enzyme family; Region: APH; pfam01636 481743013915 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743013916 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 481743013917 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 481743013918 putative metal binding site; other site 481743013919 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743013920 binding surface 481743013921 TPR motif; other site 481743013922 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 481743013923 active site 481743013924 Putative methyltransferase; Region: Methyltransf_16; pfam10294 481743013925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743013926 S-adenosylmethionine binding site [chemical binding]; other site 481743013927 Methyltransferase domain; Region: Methyltransf_31; pfam13847 481743013928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743013929 S-adenosylmethionine binding site [chemical binding]; other site 481743013930 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 481743013931 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 481743013932 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 481743013933 active site 481743013934 metal binding site [ion binding]; metal-binding site 481743013935 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 481743013936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743013937 motif II; other site 481743013938 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 481743013939 putative active site [active] 481743013940 nucleotide binding site [chemical binding]; other site 481743013941 nudix motif; other site 481743013942 putative metal binding site [ion binding]; other site 481743013943 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 481743013944 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743013945 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743013946 DNA binding residues [nucleotide binding] 481743013947 Clp protease; Region: CLP_protease; pfam00574 481743013948 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 481743013949 oligomer interface [polypeptide binding]; other site 481743013950 active site residues [active] 481743013951 Phosphotransferase enzyme family; Region: APH; pfam01636 481743013952 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743013953 active site 481743013954 ATP binding site [chemical binding]; other site 481743013955 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743013956 substrate binding site [chemical binding]; other site 481743013957 DinB superfamily; Region: DinB_2; pfam12867 481743013958 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 481743013959 Protein of unknown function (DUF952); Region: DUF952; cl01393 481743013960 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 481743013961 proposed catalytic triad [active] 481743013962 active site nucleophile [active] 481743013963 substrate binding site [chemical binding]; other site 481743013964 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743013965 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743013966 active site 481743013967 ATP binding site [chemical binding]; other site 481743013968 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 481743013969 catalytic core [active] 481743013970 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 481743013971 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743013972 Coenzyme A binding pocket [chemical binding]; other site 481743013973 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 481743013974 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 481743013975 active site 481743013976 Zn binding site [ion binding]; other site 481743013977 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 481743013978 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 481743013979 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743013980 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743013981 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 481743013982 dimerization interface [polypeptide binding]; other site 481743013983 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 481743013984 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 481743013985 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743013986 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 481743013987 motif II; other site 481743013988 RDD family; Region: RDD; pfam06271 481743013989 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 481743013990 nudix motif; other site 481743013991 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743013992 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 481743013993 metal-dependent hydrolase; Provisional; Region: PRK13291 481743013994 DinB superfamily; Region: DinB_2; pfam12867 481743013995 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 481743013996 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 481743013997 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743013998 Walker A/P-loop; other site 481743013999 ATP binding site [chemical binding]; other site 481743014000 Q-loop/lid; other site 481743014001 ABC transporter signature motif; other site 481743014002 Walker B; other site 481743014003 D-loop; other site 481743014004 H-loop/switch region; other site 481743014005 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 481743014006 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 481743014007 active site 481743014008 catalytic residues [active] 481743014009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743014010 binding surface 481743014011 TPR motif; other site 481743014012 Tetratricopeptide repeat; Region: TPR_16; pfam13432 481743014013 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743014014 binding surface 481743014015 TPR motif; other site 481743014016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743014017 binding surface 481743014018 TPR motif; other site 481743014019 TPR repeat; Region: TPR_11; pfam13414 481743014020 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743014021 binding surface 481743014022 TPR motif; other site 481743014023 Cupin domain; Region: Cupin_2; cl17218 481743014024 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743014025 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743014026 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014027 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 481743014028 Melibiase; Region: Melibiase; pfam02065 481743014029 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743014030 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743014031 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743014032 dimerization interface [polypeptide binding]; other site 481743014033 Histidine kinase; Region: His_kinase; pfam06580 481743014034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743014035 ATP binding site [chemical binding]; other site 481743014036 Mg2+ binding site [ion binding]; other site 481743014037 G-X-G motif; other site 481743014038 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 481743014039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743014040 active site 481743014041 phosphorylation site [posttranslational modification] 481743014042 intermolecular recognition site; other site 481743014043 dimerization interface [polypeptide binding]; other site 481743014044 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014045 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014046 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743014047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014048 dimer interface [polypeptide binding]; other site 481743014049 conserved gate region; other site 481743014050 ABC-ATPase subunit interface; other site 481743014051 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743014052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014053 dimer interface [polypeptide binding]; other site 481743014054 conserved gate region; other site 481743014055 ABC-ATPase subunit interface; other site 481743014056 RDD family; Region: RDD; cl00746 481743014057 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 481743014058 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 481743014059 Ca binding site [ion binding]; other site 481743014060 short chain dehydrogenase; Provisional; Region: PRK06523 481743014061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743014062 NAD(P) binding site [chemical binding]; other site 481743014063 active site 481743014064 SnoaL-like domain; Region: SnoaL_2; pfam12680 481743014065 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743014066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743014067 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 481743014068 putative dimerization interface [polypeptide binding]; other site 481743014069 Methyltransferase domain; Region: Methyltransf_23; pfam13489 481743014070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743014071 S-adenosylmethionine binding site [chemical binding]; other site 481743014072 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 481743014073 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 481743014074 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743014075 motif II; other site 481743014076 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 481743014077 nudix motif; other site 481743014078 metal-dependent hydrolase; Provisional; Region: PRK13291 481743014079 DinB superfamily; Region: DinB_2; pfam12867 481743014080 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 481743014081 nudix motif; other site 481743014082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743014083 S-adenosylmethionine binding site [chemical binding]; other site 481743014084 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 481743014085 putative catalytic site [active] 481743014086 putative metal binding site [ion binding]; other site 481743014087 putative phosphate binding site [ion binding]; other site 481743014088 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 481743014089 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743014090 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 481743014091 DinB superfamily; Region: DinB_2; pfam12867 481743014092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 481743014093 Methyltransferase domain; Region: Methyltransf_31; pfam13847 481743014094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743014095 S-adenosylmethionine binding site [chemical binding]; other site 481743014096 S-layer homology domain; Region: SLH; pfam00395 481743014097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743014098 Coenzyme A binding pocket [chemical binding]; other site 481743014099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 481743014100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743014101 Coenzyme A binding pocket [chemical binding]; other site 481743014102 SnoaL-like domain; Region: SnoaL_2; pfam12680 481743014103 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743014104 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 481743014105 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743014106 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743014107 dimerization interface [polypeptide binding]; other site 481743014108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743014109 dimer interface [polypeptide binding]; other site 481743014110 phosphorylation site [posttranslational modification] 481743014111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743014112 ATP binding site [chemical binding]; other site 481743014113 Mg2+ binding site [ion binding]; other site 481743014114 G-X-G motif; other site 481743014115 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743014116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743014117 active site 481743014118 phosphorylation site [posttranslational modification] 481743014119 intermolecular recognition site; other site 481743014120 dimerization interface [polypeptide binding]; other site 481743014121 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743014122 DNA binding site [nucleotide binding] 481743014123 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743014124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743014125 Walker A/P-loop; other site 481743014126 ATP binding site [chemical binding]; other site 481743014127 Q-loop/lid; other site 481743014128 ABC transporter signature motif; other site 481743014129 Walker B; other site 481743014130 D-loop; other site 481743014131 H-loop/switch region; other site 481743014132 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 481743014133 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 481743014134 ABC-2 type transporter; Region: ABC2_membrane; cl17235 481743014135 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 481743014136 Histidine kinase; Region: HisKA_3; pfam07730 481743014137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743014138 Mg2+ binding site [ion binding]; other site 481743014139 G-X-G motif; other site 481743014140 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743014141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743014142 active site 481743014143 phosphorylation site [posttranslational modification] 481743014144 intermolecular recognition site; other site 481743014145 dimerization interface [polypeptide binding]; other site 481743014146 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743014147 DNA binding residues [nucleotide binding] 481743014148 dimerization interface [polypeptide binding]; other site 481743014149 Methyltransferase domain; Region: Methyltransf_31; pfam13847 481743014150 Methyltransferase domain; Region: Methyltransf_12; pfam08242 481743014151 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 481743014152 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 481743014153 nudix motif; other site 481743014154 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 481743014155 dimer interface [polypeptide binding]; other site 481743014156 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 481743014157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743014158 S-adenosylmethionine binding site [chemical binding]; other site 481743014159 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 481743014160 Uncharacterized conserved protein [Function unknown]; Region: COG0327 481743014161 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 481743014162 putative active site [active] 481743014163 nucleotide binding site [chemical binding]; other site 481743014164 nudix motif; other site 481743014165 putative metal binding site [ion binding]; other site 481743014166 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 481743014167 putative active site [active] 481743014168 nucleotide binding site [chemical binding]; other site 481743014169 nudix motif; other site 481743014170 putative metal binding site [ion binding]; other site 481743014171 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 481743014172 glutamate racemase; Provisional; Region: PRK00865 481743014173 TPR repeat; Region: TPR_11; pfam13414 481743014174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743014175 TPR motif; other site 481743014176 binding surface 481743014177 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 481743014178 active site flap/lid [active] 481743014179 nucleophilic elbow; other site 481743014180 catalytic triad [active] 481743014181 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 481743014182 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743014183 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 481743014184 Predicted acetyltransferase [General function prediction only]; Region: COG5628 481743014185 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 481743014186 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743014187 motif II; other site 481743014188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743014189 S-adenosylmethionine binding site [chemical binding]; other site 481743014190 DinB family; Region: DinB; cl17821 481743014191 DinB superfamily; Region: DinB_2; pfam12867 481743014192 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743014193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014194 dimer interface [polypeptide binding]; other site 481743014195 ABC-ATPase subunit interface; other site 481743014196 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743014197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014198 dimer interface [polypeptide binding]; other site 481743014199 conserved gate region; other site 481743014200 ABC-ATPase subunit interface; other site 481743014201 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743014202 Response regulator receiver domain; Region: Response_reg; pfam00072 481743014203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743014204 active site 481743014205 phosphorylation site [posttranslational modification] 481743014206 intermolecular recognition site; other site 481743014207 dimerization interface [polypeptide binding]; other site 481743014208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014209 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743014210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014211 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743014212 HAMP domain; Region: HAMP; pfam00672 481743014213 dimerization interface [polypeptide binding]; other site 481743014214 Histidine kinase; Region: His_kinase; pfam06580 481743014215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743014216 ATP binding site [chemical binding]; other site 481743014217 Mg2+ binding site [ion binding]; other site 481743014218 G-X-G motif; other site 481743014219 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 481743014220 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 481743014221 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 481743014222 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 481743014223 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 481743014224 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 481743014225 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743014226 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 481743014227 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743014228 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014229 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743014230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014231 dimer interface [polypeptide binding]; other site 481743014232 conserved gate region; other site 481743014233 ABC-ATPase subunit interface; other site 481743014234 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743014235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014236 dimer interface [polypeptide binding]; other site 481743014237 conserved gate region; other site 481743014238 putative PBP binding loops; other site 481743014239 ABC-ATPase subunit interface; other site 481743014240 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 481743014241 nudix motif; other site 481743014242 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 481743014243 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743014244 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014245 Domain of unknown function (DUF377); Region: DUF377; pfam04041 481743014246 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 481743014247 active site 481743014248 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743014249 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743014250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014251 dimer interface [polypeptide binding]; other site 481743014252 conserved gate region; other site 481743014253 putative PBP binding loops; other site 481743014254 ABC-ATPase subunit interface; other site 481743014255 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743014256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014257 dimer interface [polypeptide binding]; other site 481743014258 conserved gate region; other site 481743014259 ABC-ATPase subunit interface; other site 481743014260 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 481743014261 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 481743014262 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 481743014263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014264 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743014265 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014266 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 481743014267 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 481743014268 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 481743014269 nudix motif; other site 481743014270 NTPase; Region: NTPase_1; cl17478 481743014271 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 481743014272 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 481743014273 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 481743014274 Walker A/P-loop; other site 481743014275 ATP binding site [chemical binding]; other site 481743014276 Q-loop/lid; other site 481743014277 ABC transporter signature motif; other site 481743014278 Walker B; other site 481743014279 D-loop; other site 481743014280 H-loop/switch region; other site 481743014281 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 481743014282 FtsX-like permease family; Region: FtsX; pfam02687 481743014283 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 481743014284 FtsX-like permease family; Region: FtsX; pfam02687 481743014285 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743014286 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743014287 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 481743014288 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 481743014289 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743014290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743014291 dimer interface [polypeptide binding]; other site 481743014292 phosphorylation site [posttranslational modification] 481743014293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743014294 ATP binding site [chemical binding]; other site 481743014295 Mg2+ binding site [ion binding]; other site 481743014296 G-X-G motif; other site 481743014297 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743014298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743014299 active site 481743014300 phosphorylation site [posttranslational modification] 481743014301 intermolecular recognition site; other site 481743014302 dimerization interface [polypeptide binding]; other site 481743014303 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743014304 DNA binding site [nucleotide binding] 481743014305 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743014306 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 481743014307 Walker A/P-loop; other site 481743014308 ATP binding site [chemical binding]; other site 481743014309 Q-loop/lid; other site 481743014310 ABC transporter signature motif; other site 481743014311 Walker B; other site 481743014312 D-loop; other site 481743014313 H-loop/switch region; other site 481743014314 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 481743014315 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 481743014316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743014317 NAD(P) binding site [chemical binding]; other site 481743014318 active site 481743014319 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 481743014320 classical (c) SDRs; Region: SDR_c; cd05233 481743014321 NAD(P) binding site [chemical binding]; other site 481743014322 active site 481743014323 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743014324 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743014325 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 481743014326 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 481743014327 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 481743014328 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 481743014329 Protein of unknown function (DUF664); Region: DUF664; pfam04978 481743014330 DinB superfamily; Region: DinB_2; pfam12867 481743014331 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 481743014332 nudix motif; other site 481743014333 hypothetical protein; Validated; Region: PRK06769 481743014334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743014335 active site 481743014336 motif I; other site 481743014337 motif II; other site 481743014338 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 481743014339 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 481743014340 Penicillinase repressor; Region: Pencillinase_R; cl17580 481743014341 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 481743014342 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 481743014343 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 481743014344 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 481743014345 Acylphosphatase; Region: Acylphosphatase; pfam00708 481743014346 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 481743014347 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 481743014348 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 481743014349 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 481743014350 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 481743014351 Walker A/P-loop; other site 481743014352 ATP binding site [chemical binding]; other site 481743014353 Q-loop/lid; other site 481743014354 ABC transporter signature motif; other site 481743014355 Walker B; other site 481743014356 D-loop; other site 481743014357 H-loop/switch region; other site 481743014358 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 481743014359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014360 dimer interface [polypeptide binding]; other site 481743014361 conserved gate region; other site 481743014362 putative PBP binding loops; other site 481743014363 ABC-ATPase subunit interface; other site 481743014364 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 481743014365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014366 dimer interface [polypeptide binding]; other site 481743014367 conserved gate region; other site 481743014368 ABC-ATPase subunit interface; other site 481743014369 AAA domain; Region: AAA_33; pfam13671 481743014370 AAA domain; Region: AAA_17; pfam13207 481743014371 YCII-related domain; Region: YCII; cl00999 481743014372 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743014373 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743014374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014375 dimer interface [polypeptide binding]; other site 481743014376 conserved gate region; other site 481743014377 putative PBP binding loops; other site 481743014378 ABC-ATPase subunit interface; other site 481743014379 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743014380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014381 ABC-ATPase subunit interface; other site 481743014382 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743014383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014384 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 481743014385 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 481743014386 Walker A/P-loop; other site 481743014387 ATP binding site [chemical binding]; other site 481743014388 Q-loop/lid; other site 481743014389 ABC transporter signature motif; other site 481743014390 Walker B; other site 481743014391 D-loop; other site 481743014392 H-loop/switch region; other site 481743014393 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 481743014394 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 481743014395 Walker A/P-loop; other site 481743014396 ATP binding site [chemical binding]; other site 481743014397 Q-loop/lid; other site 481743014398 ABC transporter signature motif; other site 481743014399 Walker B; other site 481743014400 D-loop; other site 481743014401 H-loop/switch region; other site 481743014402 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 481743014403 Phosphotransferase enzyme family; Region: APH; pfam01636 481743014404 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 481743014405 active site 481743014406 substrate binding site [chemical binding]; other site 481743014407 ATP binding site [chemical binding]; other site 481743014408 DinB superfamily; Region: DinB_2; pfam12867 481743014409 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 481743014410 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 481743014411 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 481743014412 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 481743014413 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 481743014414 NAD(P) binding site [chemical binding]; other site 481743014415 LDH/MDH dimer interface [polypeptide binding]; other site 481743014416 substrate binding site [chemical binding]; other site 481743014417 Cupin domain; Region: Cupin_2; pfam07883 481743014418 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014419 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743014420 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014421 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743014422 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743014423 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743014424 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743014425 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743014426 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743014427 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 481743014428 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743014429 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743014430 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743014431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014432 dimer interface [polypeptide binding]; other site 481743014433 conserved gate region; other site 481743014434 ABC-ATPase subunit interface; other site 481743014435 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743014436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014437 dimer interface [polypeptide binding]; other site 481743014438 conserved gate region; other site 481743014439 ABC-ATPase subunit interface; other site 481743014440 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743014441 DNA-binding site [nucleotide binding]; DNA binding site 481743014442 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743014443 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743014444 dimerization interface [polypeptide binding]; other site 481743014445 ligand binding site [chemical binding]; other site 481743014446 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 481743014447 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 481743014448 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 481743014449 active site 481743014450 dimer interface [polypeptide binding]; other site 481743014451 effector binding site; other site 481743014452 TSCPD domain; Region: TSCPD; pfam12637 481743014453 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 481743014454 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481743014455 ATP binding site [chemical binding]; other site 481743014456 putative Mg++ binding site [ion binding]; other site 481743014457 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481743014458 nucleotide binding region [chemical binding]; other site 481743014459 ATP-binding site [chemical binding]; other site 481743014460 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 481743014461 YqzE-like protein; Region: YqzE; pfam14038 481743014462 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 481743014463 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 481743014464 active site 481743014465 metal binding site [ion binding]; metal-binding site 481743014466 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 481743014467 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 481743014468 dimerization interface [polypeptide binding]; other site 481743014469 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 481743014470 dimer interface [polypeptide binding]; other site 481743014471 putative CheW interface [polypeptide binding]; other site 481743014472 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 481743014473 NodB motif; other site 481743014474 putative active site [active] 481743014475 putative catalytic site [active] 481743014476 Zn binding site [ion binding]; other site 481743014477 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 481743014478 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 481743014479 active site 481743014480 Uncharacterized membrane protein [Function unknown]; Region: COG3949 481743014481 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 481743014482 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 481743014483 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 481743014484 active site 481743014485 metal binding site [ion binding]; metal-binding site 481743014486 DNA binding site [nucleotide binding] 481743014487 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 481743014488 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 481743014489 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481743014490 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481743014491 metal binding site [ion binding]; metal-binding site 481743014492 active site 481743014493 I-site; other site 481743014494 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 481743014495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743014496 S-adenosylmethionine binding site [chemical binding]; other site 481743014497 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 481743014498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743014499 putative substrate translocation pore; other site 481743014500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743014501 MbtH-like protein; Region: MbtH; pfam03621 481743014502 Condensation domain; Region: Condensation; pfam00668 481743014503 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 481743014504 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 481743014505 acyl-activating enzyme (AAE) consensus motif; other site 481743014506 AMP binding site [chemical binding]; other site 481743014507 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 481743014508 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 481743014509 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 481743014510 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 481743014511 acyl-activating enzyme (AAE) consensus motif; other site 481743014512 AMP binding site [chemical binding]; other site 481743014513 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 481743014514 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 481743014515 hydrophobic substrate binding pocket; other site 481743014516 Isochorismatase family; Region: Isochorismatase; pfam00857 481743014517 active site 481743014518 conserved cis-peptide bond; other site 481743014519 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 481743014520 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 481743014521 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 481743014522 acyl-activating enzyme (AAE) consensus motif; other site 481743014523 active site 481743014524 AMP binding site [chemical binding]; other site 481743014525 substrate binding site [chemical binding]; other site 481743014526 isochorismate synthase DhbC; Validated; Region: PRK06923 481743014527 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 481743014528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743014529 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 481743014530 NAD(P) binding site [chemical binding]; other site 481743014531 active site 481743014532 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 481743014533 Putative esterase; Region: Esterase; pfam00756 481743014534 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 481743014535 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 481743014536 intersubunit interface [polypeptide binding]; other site 481743014537 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743014538 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014539 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014540 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 481743014541 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 481743014542 intersubunit interface [polypeptide binding]; other site 481743014543 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743014544 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 481743014545 active site 481743014546 motif I; other site 481743014547 motif II; other site 481743014548 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 481743014549 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 481743014550 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 481743014551 RNA binding surface [nucleotide binding]; other site 481743014552 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 481743014553 active site 481743014554 uracil binding [chemical binding]; other site 481743014555 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 481743014556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743014557 S-adenosylmethionine binding site [chemical binding]; other site 481743014558 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 481743014559 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 481743014560 catalytic residues [active] 481743014561 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 481743014562 Domain of unknown function (DUF309); Region: DUF309; pfam03745 481743014563 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 481743014564 synthetase active site [active] 481743014565 NTP binding site [chemical binding]; other site 481743014566 metal binding site [ion binding]; metal-binding site 481743014567 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 481743014568 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 481743014569 quinone interaction residues [chemical binding]; other site 481743014570 active site 481743014571 catalytic residues [active] 481743014572 FMN binding site [chemical binding]; other site 481743014573 substrate binding site [chemical binding]; other site 481743014574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 481743014575 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 481743014576 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 481743014577 DNA polymerase IV; Validated; Region: PRK01810 481743014578 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 481743014579 active site 481743014580 DNA binding site [nucleotide binding] 481743014581 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 481743014582 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 481743014583 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 481743014584 active site 481743014585 catalytic residues [active] 481743014586 metal binding site [ion binding]; metal-binding site 481743014587 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 481743014588 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 481743014589 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 481743014590 catalytic residues [active] 481743014591 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 481743014592 MPN+ (JAMM) motif; other site 481743014593 Zinc-binding site [ion binding]; other site 481743014594 hypothetical protein; Provisional; Region: PRK07740 481743014595 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 481743014596 active site 481743014597 catalytic site [active] 481743014598 substrate binding site [chemical binding]; other site 481743014599 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 481743014600 metal binding triad; other site 481743014601 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 481743014602 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 481743014603 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 481743014604 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 481743014605 DNA binding residues [nucleotide binding] 481743014606 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 481743014607 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743014608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743014609 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 481743014610 putative dimerization interface [polypeptide binding]; other site 481743014611 Rhomboid family; Region: Rhomboid; pfam01694 481743014612 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 481743014613 dimer interface [polypeptide binding]; other site 481743014614 catalytic triad [active] 481743014615 peroxidatic and resolving cysteines [active] 481743014616 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 481743014617 Protein of unknown function, DUF624; Region: DUF624; cl02369 481743014618 helicase 45; Provisional; Region: PTZ00424 481743014619 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 481743014620 ATP binding site [chemical binding]; other site 481743014621 Mg++ binding site [ion binding]; other site 481743014622 motif III; other site 481743014623 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481743014624 nucleotide binding region [chemical binding]; other site 481743014625 ATP-binding site [chemical binding]; other site 481743014626 Uncharacterized conserved protein [Function unknown]; Region: COG1284 481743014627 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 481743014628 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 481743014629 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 481743014630 multidrug efflux protein; Reviewed; Region: PRK01766 481743014631 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 481743014632 cation binding site [ion binding]; other site 481743014633 6-phosphofructokinase; Provisional; Region: PRK03202 481743014634 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 481743014635 active site 481743014636 ADP/pyrophosphate binding site [chemical binding]; other site 481743014637 dimerization interface [polypeptide binding]; other site 481743014638 allosteric effector site; other site 481743014639 fructose-1,6-bisphosphate binding site; other site 481743014640 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 481743014641 MFS_1 like family; Region: MFS_1_like; pfam12832 481743014642 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743014643 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 481743014644 DNA-binding site [nucleotide binding]; DNA binding site 481743014645 RNA-binding motif; other site 481743014646 oligoendopeptidase F; Region: pepF; TIGR00181 481743014647 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 481743014648 active site 481743014649 Zn binding site [ion binding]; other site 481743014650 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 481743014651 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 481743014652 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 481743014653 putative oligomer interface [polypeptide binding]; other site 481743014654 putative active site [active] 481743014655 metal binding site [ion binding]; metal-binding site 481743014656 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 481743014657 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743014658 Walker A/P-loop; other site 481743014659 ATP binding site [chemical binding]; other site 481743014660 Q-loop/lid; other site 481743014661 ABC transporter signature motif; other site 481743014662 Walker B; other site 481743014663 D-loop; other site 481743014664 H-loop/switch region; other site 481743014665 ABC transporter; Region: ABC_tran_2; pfam12848 481743014666 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481743014667 Integral membrane protein DUF92; Region: DUF92; pfam01940 481743014668 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 481743014669 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 481743014670 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 481743014671 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 481743014672 active site 481743014673 catalytic site [active] 481743014674 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 481743014675 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 481743014676 putative active site [active] 481743014677 putative metal binding site [ion binding]; other site 481743014678 ferrochelatase; Provisional; Region: PRK12435 481743014679 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 481743014680 C-terminal domain interface [polypeptide binding]; other site 481743014681 active site 481743014682 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 481743014683 active site 481743014684 N-terminal domain interface [polypeptide binding]; other site 481743014685 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 481743014686 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 481743014687 substrate binding site [chemical binding]; other site 481743014688 active site 481743014689 drug efflux system protein MdtG; Provisional; Region: PRK09874 481743014690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743014691 putative substrate translocation pore; other site 481743014692 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 481743014693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 481743014694 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 481743014695 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 481743014696 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 481743014697 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 481743014698 Sulfatase; Region: Sulfatase; pfam00884 481743014699 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 481743014700 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 481743014701 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 481743014702 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 481743014703 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 481743014704 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 481743014705 putative active site [active] 481743014706 Zn binding site [ion binding]; other site 481743014707 glutamate racemase; Provisional; Region: PRK00865 481743014708 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 481743014709 active site 481743014710 dimer interface [polypeptide binding]; other site 481743014711 YtxH-like protein; Region: YtxH; pfam12732 481743014712 Uncharacterized conserved protein [Function unknown]; Region: COG2445 481743014713 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 481743014714 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 481743014715 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 481743014716 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481743014717 non-specific DNA binding site [nucleotide binding]; other site 481743014718 salt bridge; other site 481743014719 sequence-specific DNA binding site [nucleotide binding]; other site 481743014720 Helix-turn-helix domain; Region: HTH_17; pfam12728 481743014721 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 481743014722 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743014723 YhhN-like protein; Region: YhhN; pfam07947 481743014724 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 481743014725 MgtC family; Region: MgtC; pfam02308 481743014726 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 481743014727 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 481743014728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743014729 active site 481743014730 motif I; other site 481743014731 motif II; other site 481743014732 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743014733 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 481743014734 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743014735 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014736 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743014737 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014738 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743014739 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743014740 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743014741 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 481743014742 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 481743014743 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743014744 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743014745 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743014746 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 481743014747 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 481743014748 Metal-binding active site; metal-binding site 481743014749 Cupin domain; Region: Cupin_2; cl17218 481743014750 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743014751 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014752 hypothetical protein; Validated; Region: PRK07682 481743014753 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743014754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743014755 homodimer interface [polypeptide binding]; other site 481743014756 catalytic residue [active] 481743014757 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 481743014758 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 481743014759 ATP-grasp domain; Region: ATP-grasp_4; cl17255 481743014760 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 481743014761 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743014762 DNA-binding site [nucleotide binding]; DNA binding site 481743014763 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743014764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743014765 homodimer interface [polypeptide binding]; other site 481743014766 catalytic residue [active] 481743014767 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 481743014768 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 481743014769 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 481743014770 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 481743014771 sugar binding site [chemical binding]; other site 481743014772 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743014773 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743014774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014775 dimer interface [polypeptide binding]; other site 481743014776 conserved gate region; other site 481743014777 ABC-ATPase subunit interface; other site 481743014778 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743014779 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 481743014780 Helix-turn-helix domain; Region: HTH_18; pfam12833 481743014781 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 481743014782 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743014783 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 481743014784 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743014785 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 481743014786 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 481743014787 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743014788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014789 dimer interface [polypeptide binding]; other site 481743014790 conserved gate region; other site 481743014791 putative PBP binding loops; other site 481743014792 ABC-ATPase subunit interface; other site 481743014793 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743014794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014795 dimer interface [polypeptide binding]; other site 481743014796 conserved gate region; other site 481743014797 putative PBP binding loops; other site 481743014798 ABC-ATPase subunit interface; other site 481743014799 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743014800 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743014801 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 481743014802 Peptidase M60-like family; Region: M60-like; pfam13402 481743014803 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 481743014804 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481743014805 non-specific DNA binding site [nucleotide binding]; other site 481743014806 salt bridge; other site 481743014807 sequence-specific DNA binding site [nucleotide binding]; other site 481743014808 Cupin domain; Region: Cupin_2; pfam07883 481743014809 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 481743014810 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743014811 NAD(P) binding site [chemical binding]; other site 481743014812 active site 481743014813 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 481743014814 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 481743014815 substrate-cofactor binding pocket; other site 481743014816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743014817 catalytic residue [active] 481743014818 Peptidase M60-like family; Region: M60-like; pfam13402 481743014819 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743014820 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743014821 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014822 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014823 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743014824 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743014825 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 481743014826 dimerization interface [polypeptide binding]; other site 481743014827 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 481743014828 active site 1 [active] 481743014829 dimer interface [polypeptide binding]; other site 481743014830 hexamer interface [polypeptide binding]; other site 481743014831 active site 2 [active] 481743014832 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743014833 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743014834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743014835 Walker A/P-loop; other site 481743014836 ATP binding site [chemical binding]; other site 481743014837 Q-loop/lid; other site 481743014838 ABC transporter signature motif; other site 481743014839 Walker B; other site 481743014840 D-loop; other site 481743014841 H-loop/switch region; other site 481743014842 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743014843 Walker A/P-loop; other site 481743014844 ATP binding site [chemical binding]; other site 481743014845 Q-loop/lid; other site 481743014846 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 481743014847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743014848 ABC transporter signature motif; other site 481743014849 Walker B; other site 481743014850 D-loop; other site 481743014851 H-loop/switch region; other site 481743014852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743014853 Walker A/P-loop; other site 481743014854 ATP binding site [chemical binding]; other site 481743014855 Q-loop/lid; other site 481743014856 ABC transporter signature motif; other site 481743014857 Walker B; other site 481743014858 D-loop; other site 481743014859 H-loop/switch region; other site 481743014860 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 481743014861 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 481743014862 CGNR zinc finger; Region: zf-CGNR; pfam11706 481743014863 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 481743014864 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 481743014865 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 481743014866 DNA binding residues [nucleotide binding] 481743014867 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 481743014868 putative dimer interface [polypeptide binding]; other site 481743014869 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 481743014870 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 481743014871 DNA binding residues [nucleotide binding] 481743014872 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 481743014873 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 481743014874 putative NAD(P) binding site [chemical binding]; other site 481743014875 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743014876 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743014877 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 481743014878 dimerization interface [polypeptide binding]; other site 481743014879 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743014880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743014881 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 481743014882 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 481743014883 Cupin; Region: Cupin_1; smart00835 481743014884 Cupin; Region: Cupin_1; smart00835 481743014885 MarR family; Region: MarR_2; cl17246 481743014886 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481743014887 MMPL family; Region: MMPL; pfam03176 481743014888 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 481743014889 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 481743014890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743014891 S-adenosylmethionine binding site [chemical binding]; other site 481743014892 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743014893 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743014894 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 481743014895 dimerization interface [polypeptide binding]; other site 481743014896 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743014897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014898 dimer interface [polypeptide binding]; other site 481743014899 conserved gate region; other site 481743014900 putative PBP binding loops; other site 481743014901 ABC-ATPase subunit interface; other site 481743014902 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743014903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014904 dimer interface [polypeptide binding]; other site 481743014905 conserved gate region; other site 481743014906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 481743014907 ABC-ATPase subunit interface; other site 481743014908 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743014909 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743014910 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743014911 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014912 Predicted transcriptional regulators [Transcription]; Region: COG1733 481743014913 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 481743014914 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 481743014915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743014916 putative substrate translocation pore; other site 481743014917 Cupin; Region: Cupin_1; smart00835 481743014918 hypothetical protein; Provisional; Region: PRK08201 481743014919 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 481743014920 metal binding site [ion binding]; metal-binding site 481743014921 putative dimer interface [polypeptide binding]; other site 481743014922 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 481743014923 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 481743014924 NAD binding site [chemical binding]; other site 481743014925 catalytic Zn binding site [ion binding]; other site 481743014926 structural Zn binding site [ion binding]; other site 481743014927 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 481743014928 Phosphotransferase enzyme family; Region: APH; pfam01636 481743014929 active site 481743014930 ATP binding site [chemical binding]; other site 481743014931 DinB family; Region: DinB; cl17821 481743014932 DinB superfamily; Region: DinB_2; pfam12867 481743014933 Predicted transcriptional regulator [Transcription]; Region: COG2378 481743014934 HTH domain; Region: HTH_11; pfam08279 481743014935 WYL domain; Region: WYL; pfam13280 481743014936 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 481743014937 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743014938 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743014939 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014940 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743014941 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 481743014942 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 481743014943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743014944 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 481743014945 Walker A/P-loop; other site 481743014946 ATP binding site [chemical binding]; other site 481743014947 Q-loop/lid; other site 481743014948 ABC transporter signature motif; other site 481743014949 Walker B; other site 481743014950 D-loop; other site 481743014951 H-loop/switch region; other site 481743014952 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 481743014953 ABC-2 type transporter; Region: ABC2_membrane; cl17235 481743014954 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743014955 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743014956 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 481743014957 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743014958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014959 dimer interface [polypeptide binding]; other site 481743014960 conserved gate region; other site 481743014961 putative PBP binding loops; other site 481743014962 ABC-ATPase subunit interface; other site 481743014963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743014964 dimer interface [polypeptide binding]; other site 481743014965 conserved gate region; other site 481743014966 putative PBP binding loops; other site 481743014967 ABC-ATPase subunit interface; other site 481743014968 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743014969 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743014970 Predicted integral membrane protein [Function unknown]; Region: COG5500 481743014971 Peptidases of the G1 family, including scytalidoglutamic peptidase and aspergillopepsin; Region: Peptidase_G1; cd13426 481743014972 polypeptide substrate binding site [polypeptide binding]; other site 481743014973 active site 481743014974 putative deaminase; Validated; Region: PRK06846 481743014975 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 481743014976 active site 481743014977 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 481743014978 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 481743014979 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 481743014980 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743014981 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743014982 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 481743014983 dimerization interface [polypeptide binding]; other site 481743014984 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743014985 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743014986 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 481743014987 Walker A/P-loop; other site 481743014988 ATP binding site [chemical binding]; other site 481743014989 Q-loop/lid; other site 481743014990 ABC transporter signature motif; other site 481743014991 Walker B; other site 481743014992 D-loop; other site 481743014993 H-loop/switch region; other site 481743014994 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743014995 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743014996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743014997 Walker A/P-loop; other site 481743014998 ATP binding site [chemical binding]; other site 481743014999 Q-loop/lid; other site 481743015000 ABC transporter signature motif; other site 481743015001 Walker B; other site 481743015002 D-loop; other site 481743015003 H-loop/switch region; other site 481743015004 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 481743015005 Part of AAA domain; Region: AAA_19; pfam13245 481743015006 Family description; Region: UvrD_C_2; pfam13538 481743015007 ABC-2 type transporter; Region: ABC2_membrane; cl17235 481743015008 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 481743015009 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743015010 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 481743015011 Walker A/P-loop; other site 481743015012 ATP binding site [chemical binding]; other site 481743015013 Q-loop/lid; other site 481743015014 ABC transporter signature motif; other site 481743015015 Walker B; other site 481743015016 D-loop; other site 481743015017 H-loop/switch region; other site 481743015018 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 481743015019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743015020 NADH(P)-binding; Region: NAD_binding_10; pfam13460 481743015021 NAD(P) binding site [chemical binding]; other site 481743015022 active site 481743015023 Predicted transcriptional regulator [Transcription]; Region: COG2378 481743015024 HTH domain; Region: HTH_11; pfam08279 481743015025 WYL domain; Region: WYL; pfam13280 481743015026 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 481743015027 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 481743015028 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 481743015029 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 481743015030 AsnC family; Region: AsnC_trans_reg; pfam01037 481743015031 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743015032 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481743015033 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743015034 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743015035 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743015036 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743015037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743015038 dimer interface [polypeptide binding]; other site 481743015039 conserved gate region; other site 481743015040 putative PBP binding loops; other site 481743015041 ABC-ATPase subunit interface; other site 481743015042 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743015043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743015044 dimer interface [polypeptide binding]; other site 481743015045 conserved gate region; other site 481743015046 ABC-ATPase subunit interface; other site 481743015047 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743015048 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743015049 DNA binding site [nucleotide binding] 481743015050 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743015051 ligand binding site [chemical binding]; other site 481743015052 dimerization interface [polypeptide binding]; other site 481743015053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743015054 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743015055 putative substrate translocation pore; other site 481743015056 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743015057 dimerization interface [polypeptide binding]; other site 481743015058 putative DNA binding site [nucleotide binding]; other site 481743015059 putative Zn2+ binding site [ion binding]; other site 481743015060 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 481743015061 2-isopropylmalate synthase; Validated; Region: PRK00915 481743015062 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 481743015063 active site 481743015064 catalytic residues [active] 481743015065 metal binding site [ion binding]; metal-binding site 481743015066 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 481743015067 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 481743015068 Chorismate mutase type II; Region: CM_2; cl00693 481743015069 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 481743015070 Predicted membrane protein [Function unknown]; Region: COG2311 481743015071 Protein of unknown function (DUF418); Region: DUF418; pfam04235 481743015072 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743015073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743015074 active site 481743015075 phosphorylation site [posttranslational modification] 481743015076 intermolecular recognition site; other site 481743015077 dimerization interface [polypeptide binding]; other site 481743015078 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743015079 DNA binding site [nucleotide binding] 481743015080 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743015081 HAMP domain; Region: HAMP; pfam00672 481743015082 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743015083 dimer interface [polypeptide binding]; other site 481743015084 phosphorylation site [posttranslational modification] 481743015085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743015086 ATP binding site [chemical binding]; other site 481743015087 Mg2+ binding site [ion binding]; other site 481743015088 G-X-G motif; other site 481743015089 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 481743015090 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 481743015091 generic binding surface I; other site 481743015092 generic binding surface II; other site 481743015093 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 481743015094 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481743015095 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481743015096 active site 481743015097 catalytic tetrad [active] 481743015098 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 481743015099 MgtE intracellular N domain; Region: MgtE_N; pfam03448 481743015100 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 481743015101 Divalent cation transporter; Region: MgtE; pfam01769 481743015102 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 481743015103 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 481743015104 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 481743015105 NAD(P) binding site [chemical binding]; other site 481743015106 active site 481743015107 Predicted transcriptional regulators [Transcription]; Region: COG1733 481743015108 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 481743015109 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 481743015110 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743015111 DNA-binding site [nucleotide binding]; DNA binding site 481743015112 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743015113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743015114 homodimer interface [polypeptide binding]; other site 481743015115 catalytic residue [active] 481743015116 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 481743015117 substrate binding site [chemical binding]; other site 481743015118 active site 481743015119 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 481743015120 SdpI/YhfL protein family; Region: SdpI; pfam13630 481743015121 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743015122 dimerization interface [polypeptide binding]; other site 481743015123 putative DNA binding site [nucleotide binding]; other site 481743015124 putative Zn2+ binding site [ion binding]; other site 481743015125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743015126 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 481743015127 Coenzyme A binding pocket [chemical binding]; other site 481743015128 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743015129 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743015130 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 481743015131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743015132 putative substrate translocation pore; other site 481743015133 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 481743015134 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 481743015135 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743015136 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 481743015137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743015138 NAD(P) binding site [chemical binding]; other site 481743015139 active site 481743015140 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 481743015141 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 481743015142 putative hydrophobic ligand binding site [chemical binding]; other site 481743015143 Predicted transcriptional regulator [Transcription]; Region: COG2378 481743015144 HTH domain; Region: HTH_11; pfam08279 481743015145 WYL domain; Region: WYL; pfam13280 481743015146 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 481743015147 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 481743015148 putative NAD(P) binding site [chemical binding]; other site 481743015149 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 481743015150 AAA ATPase domain; Region: AAA_16; pfam13191 481743015151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743015152 TPR motif; other site 481743015153 binding surface 481743015154 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743015155 DNA binding residues [nucleotide binding] 481743015156 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 481743015157 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 481743015158 FMN binding site [chemical binding]; other site 481743015159 substrate binding site [chemical binding]; other site 481743015160 putative catalytic residue [active] 481743015161 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 481743015162 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 481743015163 active site 481743015164 HIGH motif; other site 481743015165 dimer interface [polypeptide binding]; other site 481743015166 KMSKS motif; other site 481743015167 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 481743015168 RNA binding surface [nucleotide binding]; other site 481743015169 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 481743015170 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 481743015171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743015172 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 481743015173 Walker A/P-loop; other site 481743015174 ATP binding site [chemical binding]; other site 481743015175 Q-loop/lid; other site 481743015176 ABC transporter signature motif; other site 481743015177 Walker B; other site 481743015178 D-loop; other site 481743015179 H-loop/switch region; other site 481743015180 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 481743015181 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 481743015182 S-layer homology domain; Region: SLH; pfam00395 481743015183 S-layer homology domain; Region: SLH; pfam00395 481743015184 S-layer homology domain; Region: SLH; pfam00395 481743015185 Predicted transcriptional regulator [Transcription]; Region: COG4189 481743015186 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743015187 dimerization interface [polypeptide binding]; other site 481743015188 putative DNA binding site [nucleotide binding]; other site 481743015189 putative Zn2+ binding site [ion binding]; other site 481743015190 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 481743015191 active site 481743015192 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 481743015193 Ca binding site [ion binding]; other site 481743015194 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 481743015195 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 481743015196 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 481743015197 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 481743015198 active site 481743015199 catalytic residues [active] 481743015200 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 481743015201 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 481743015202 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 481743015203 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743015204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743015205 dimer interface [polypeptide binding]; other site 481743015206 ABC-ATPase subunit interface; other site 481743015207 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743015208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743015209 dimer interface [polypeptide binding]; other site 481743015210 conserved gate region; other site 481743015211 ABC-ATPase subunit interface; other site 481743015212 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743015213 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743015214 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 481743015215 active site 481743015216 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 481743015217 Uncharacterized conserved protein [Function unknown]; Region: COG1262 481743015218 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 481743015219 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 481743015220 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743015221 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 481743015222 legume lectins; Region: lectin_L-type; cd01951 481743015223 homotetramer interaction site [polypeptide binding]; other site 481743015224 carbohydrate binding site [chemical binding]; other site 481743015225 metal binding site [ion binding]; metal-binding site 481743015226 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 481743015227 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 481743015228 Interdomain contacts; other site 481743015229 Cytokine receptor motif; other site 481743015230 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 481743015231 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 481743015232 Cna protein B-type domain; Region: Cna_B_2; pfam13715 481743015233 S-layer homology domain; Region: SLH; pfam00395 481743015234 S-layer homology domain; Region: SLH; pfam00395 481743015235 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743015236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743015237 active site 481743015238 phosphorylation site [posttranslational modification] 481743015239 intermolecular recognition site; other site 481743015240 dimerization interface [polypeptide binding]; other site 481743015241 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743015242 DNA binding site [nucleotide binding] 481743015243 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743015244 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743015245 dimerization interface [polypeptide binding]; other site 481743015246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743015247 dimer interface [polypeptide binding]; other site 481743015248 phosphorylation site [posttranslational modification] 481743015249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743015250 ATP binding site [chemical binding]; other site 481743015251 Mg2+ binding site [ion binding]; other site 481743015252 G-X-G motif; other site 481743015253 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 481743015254 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 481743015255 Walker A/P-loop; other site 481743015256 ATP binding site [chemical binding]; other site 481743015257 Q-loop/lid; other site 481743015258 ABC transporter signature motif; other site 481743015259 Walker B; other site 481743015260 D-loop; other site 481743015261 H-loop/switch region; other site 481743015262 FtsX-like permease family; Region: FtsX; pfam02687 481743015263 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 481743015264 FtsX-like permease family; Region: FtsX; pfam02687 481743015265 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 481743015266 M20 Peptidase Aminoacylase 1-like protein 2, amidohydrolase family; Region: M20_Acy1L2_like_2; cd09849 481743015267 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 481743015268 metal binding site [ion binding]; metal-binding site 481743015269 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 481743015270 putative NAD(P) binding site [chemical binding]; other site 481743015271 homodimer interface [polypeptide binding]; other site 481743015272 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743015273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743015274 dimer interface [polypeptide binding]; other site 481743015275 conserved gate region; other site 481743015276 putative PBP binding loops; other site 481743015277 ABC-ATPase subunit interface; other site 481743015278 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743015279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743015280 dimer interface [polypeptide binding]; other site 481743015281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 481743015282 ABC-ATPase subunit interface; other site 481743015283 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743015284 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743015285 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 481743015286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743015287 Histidine kinase; Region: His_kinase; pfam06580 481743015288 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 481743015289 ATP binding site [chemical binding]; other site 481743015290 G-X-G motif; other site 481743015291 Response regulator receiver domain; Region: Response_reg; pfam00072 481743015292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743015293 active site 481743015294 phosphorylation site [posttranslational modification] 481743015295 intermolecular recognition site; other site 481743015296 dimerization interface [polypeptide binding]; other site 481743015297 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743015298 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743015299 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743015300 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 481743015301 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 481743015302 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 481743015303 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 481743015304 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 481743015305 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 481743015306 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 481743015307 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743015308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743015309 dimer interface [polypeptide binding]; other site 481743015310 conserved gate region; other site 481743015311 putative PBP binding loops; other site 481743015312 ABC-ATPase subunit interface; other site 481743015313 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 481743015314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743015315 dimer interface [polypeptide binding]; other site 481743015316 conserved gate region; other site 481743015317 putative PBP binding loops; other site 481743015318 ABC-ATPase subunit interface; other site 481743015319 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743015320 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743015321 HAMP domain; Region: HAMP; pfam00672 481743015322 Histidine kinase; Region: His_kinase; pfam06580 481743015323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743015324 ATP binding site [chemical binding]; other site 481743015325 Mg2+ binding site [ion binding]; other site 481743015326 G-X-G motif; other site 481743015327 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 481743015328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743015329 active site 481743015330 phosphorylation site [posttranslational modification] 481743015331 intermolecular recognition site; other site 481743015332 dimerization interface [polypeptide binding]; other site 481743015333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743015334 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 481743015335 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 481743015336 putative NAD(P) binding site [chemical binding]; other site 481743015337 catalytic Zn binding site [ion binding]; other site 481743015338 structural Zn binding site [ion binding]; other site 481743015339 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481743015340 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481743015341 active site 481743015342 catalytic tetrad [active] 481743015343 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 481743015344 Amidohydrolase; Region: Amidohydro_2; pfam04909 481743015345 active site 481743015346 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743015347 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743015348 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743015349 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743015350 dimerization interface [polypeptide binding]; other site 481743015351 putative DNA binding site [nucleotide binding]; other site 481743015352 putative Zn2+ binding site [ion binding]; other site 481743015353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743015354 NmrA-like family; Region: NmrA; pfam05368 481743015355 NAD(P) binding site [chemical binding]; other site 481743015356 active site 481743015357 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 481743015358 dimer interface [polypeptide binding]; other site 481743015359 catalytic triad [active] 481743015360 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 481743015361 active site 481743015362 galactonate dehydratase; Provisional; Region: PRK14017 481743015363 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 481743015364 putative active site pocket [active] 481743015365 putative metal binding site [ion binding]; other site 481743015366 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 481743015367 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 481743015368 active site 481743015369 intersubunit interface [polypeptide binding]; other site 481743015370 catalytic residue [active] 481743015371 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 481743015372 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 481743015373 Asp-box motif; other site 481743015374 Asp-box motif; other site 481743015375 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 481743015376 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 481743015377 putative sugar binding sites [chemical binding]; other site 481743015378 Q-X-W motif; other site 481743015379 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 481743015380 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 481743015381 active site 481743015382 Cupin domain; Region: Cupin_2; pfam07883 481743015383 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743015384 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743015385 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743015386 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 481743015387 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 481743015388 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 481743015389 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 481743015390 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 481743015391 dimerization domain swap beta strand [polypeptide binding]; other site 481743015392 regulatory protein interface [polypeptide binding]; other site 481743015393 active site 481743015394 regulatory phosphorylation site [posttranslational modification]; other site 481743015395 hypothetical protein; Provisional; Region: PRK02947 481743015396 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 481743015397 putative active site [active] 481743015398 Creatinine amidohydrolase; Region: Creatininase; pfam02633 481743015399 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 481743015400 active site 481743015401 substrate binding pocket [chemical binding]; other site 481743015402 homodimer interaction site [polypeptide binding]; other site 481743015403 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 481743015404 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 481743015405 active site 481743015406 P-loop; other site 481743015407 phosphorylation site [posttranslational modification] 481743015408 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 481743015409 active site 481743015410 phosphorylation site [posttranslational modification] 481743015411 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 481743015412 HTH domain; Region: HTH_11; pfam08279 481743015413 PRD domain; Region: PRD; pfam00874 481743015414 PRD domain; Region: PRD; pfam00874 481743015415 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 481743015416 active site 481743015417 P-loop; other site 481743015418 phosphorylation site [posttranslational modification] 481743015419 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 481743015420 active site 481743015421 phosphorylation site [posttranslational modification] 481743015422 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743015423 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743015424 dimerization interface [polypeptide binding]; other site 481743015425 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743015426 dimer interface [polypeptide binding]; other site 481743015427 phosphorylation site [posttranslational modification] 481743015428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743015429 ATP binding site [chemical binding]; other site 481743015430 Mg2+ binding site [ion binding]; other site 481743015431 G-X-G motif; other site 481743015432 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743015433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743015434 active site 481743015435 phosphorylation site [posttranslational modification] 481743015436 intermolecular recognition site; other site 481743015437 dimerization interface [polypeptide binding]; other site 481743015438 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743015439 DNA binding site [nucleotide binding] 481743015440 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 481743015441 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 481743015442 inhibitor binding site; inhibition site 481743015443 active site 481743015444 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743015445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743015446 dimer interface [polypeptide binding]; other site 481743015447 conserved gate region; other site 481743015448 ABC-ATPase subunit interface; other site 481743015449 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743015450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743015451 dimer interface [polypeptide binding]; other site 481743015452 conserved gate region; other site 481743015453 ABC-ATPase subunit interface; other site 481743015454 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743015455 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 481743015456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743015457 Response regulator receiver domain; Region: Response_reg; pfam00072 481743015458 active site 481743015459 phosphorylation site [posttranslational modification] 481743015460 intermolecular recognition site; other site 481743015461 dimerization interface [polypeptide binding]; other site 481743015462 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743015463 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743015464 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 481743015465 dimerization interface [polypeptide binding]; other site 481743015466 Histidine kinase; Region: His_kinase; pfam06580 481743015467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743015468 ATP binding site [chemical binding]; other site 481743015469 Mg2+ binding site [ion binding]; other site 481743015470 G-X-G motif; other site 481743015471 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 481743015472 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743015473 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743015474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743015475 ABC-ATPase subunit interface; other site 481743015476 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743015477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743015478 dimer interface [polypeptide binding]; other site 481743015479 conserved gate region; other site 481743015480 putative PBP binding loops; other site 481743015481 ABC-ATPase subunit interface; other site 481743015482 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 481743015483 Helix-turn-helix domain; Region: HTH_18; pfam12833 481743015484 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743015485 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 481743015486 active site 481743015487 catalytic triad [active] 481743015488 oxyanion hole [active] 481743015489 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 481743015490 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743015491 DNA-binding site [nucleotide binding]; DNA binding site 481743015492 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743015493 dimerization interface [polypeptide binding]; other site 481743015494 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 481743015495 ligand binding site [chemical binding]; other site 481743015496 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 481743015497 active site 481743015498 catalytic triad [active] 481743015499 oxyanion hole [active] 481743015500 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743015501 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 481743015502 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743015503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743015504 dimer interface [polypeptide binding]; other site 481743015505 conserved gate region; other site 481743015506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 481743015507 ABC-ATPase subunit interface; other site 481743015508 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743015509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743015510 dimer interface [polypeptide binding]; other site 481743015511 conserved gate region; other site 481743015512 putative PBP binding loops; other site 481743015513 ABC-ATPase subunit interface; other site 481743015514 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743015515 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743015516 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 481743015517 active site 481743015518 catalytic site [active] 481743015519 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 481743015520 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 481743015521 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743015522 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743015523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743015524 dimer interface [polypeptide binding]; other site 481743015525 ABC-ATPase subunit interface; other site 481743015526 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743015527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 481743015528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743015529 dimer interface [polypeptide binding]; other site 481743015530 putative PBP binding loops; other site 481743015531 ABC-ATPase subunit interface; other site 481743015532 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743015533 Protein of unknown function (DUF1677); Region: DUF1677; pfam07911 481743015534 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743015535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743015536 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 481743015537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743015538 DNA-binding site [nucleotide binding]; DNA binding site 481743015539 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743015540 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743015541 dimerization interface [polypeptide binding]; other site 481743015542 ligand binding site [chemical binding]; other site 481743015543 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 481743015544 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 481743015545 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 481743015546 Spore germination protein; Region: Spore_permease; cl17796 481743015547 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 481743015548 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 481743015549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743015550 dimer interface [polypeptide binding]; other site 481743015551 conserved gate region; other site 481743015552 putative PBP binding loops; other site 481743015553 ABC-ATPase subunit interface; other site 481743015554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743015555 dimer interface [polypeptide binding]; other site 481743015556 conserved gate region; other site 481743015557 putative PBP binding loops; other site 481743015558 ABC-ATPase subunit interface; other site 481743015559 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 481743015560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743015561 Walker A/P-loop; other site 481743015562 ATP binding site [chemical binding]; other site 481743015563 Q-loop/lid; other site 481743015564 ABC transporter signature motif; other site 481743015565 Walker B; other site 481743015566 D-loop; other site 481743015567 H-loop/switch region; other site 481743015568 TOBE domain; Region: TOBE_2; pfam08402 481743015569 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 481743015570 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 481743015571 putative hydrolase; Provisional; Region: PRK02113 481743015572 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 481743015573 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 481743015574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743015575 DNA-binding site [nucleotide binding]; DNA binding site 481743015576 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 481743015577 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743015578 ligand binding site [chemical binding]; other site 481743015579 dimerization interface [polypeptide binding]; other site 481743015580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743015581 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743015582 putative substrate translocation pore; other site 481743015583 Predicted transcriptional regulators [Transcription]; Region: COG1733 481743015584 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 481743015585 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743015586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743015587 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 481743015588 NAD(P) binding site [chemical binding]; other site 481743015589 active site 481743015590 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 481743015591 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 481743015592 putative NAD(P) binding site [chemical binding]; other site 481743015593 short chain dehydrogenase; Provisional; Region: PRK06500 481743015594 classical (c) SDRs; Region: SDR_c; cd05233 481743015595 NAD(P) binding site [chemical binding]; other site 481743015596 active site 481743015597 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743015598 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743015599 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 481743015600 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 481743015601 PYR/PP interface [polypeptide binding]; other site 481743015602 dimer interface [polypeptide binding]; other site 481743015603 TPP binding site [chemical binding]; other site 481743015604 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 481743015605 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 481743015606 TPP-binding site [chemical binding]; other site 481743015607 dimer interface [polypeptide binding]; other site 481743015608 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481743015609 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 481743015610 sequence-specific DNA binding site [nucleotide binding]; other site 481743015611 salt bridge; other site 481743015612 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 481743015613 short chain dehydrogenase; Provisional; Region: PRK06482 481743015614 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 481743015615 NADP binding site [chemical binding]; other site 481743015616 active site 481743015617 steroid binding site; other site 481743015618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481743015619 salt bridge; other site 481743015620 non-specific DNA binding site [nucleotide binding]; other site 481743015621 sequence-specific DNA binding site [nucleotide binding]; other site 481743015622 Predicted flavoprotein [General function prediction only]; Region: COG0431 481743015623 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 481743015624 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 481743015625 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 481743015626 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 481743015627 DNA binding residues [nucleotide binding] 481743015628 putative dimer interface [polypeptide binding]; other site 481743015629 TUP1-like enhancer of split; Region: Hira; pfam07569 481743015630 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 481743015631 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481743015632 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743015633 dimerization interface [polypeptide binding]; other site 481743015634 putative Zn2+ binding site [ion binding]; other site 481743015635 putative DNA binding site [nucleotide binding]; other site 481743015636 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 481743015637 homotrimer interaction site [polypeptide binding]; other site 481743015638 putative active site [active] 481743015639 hypothetical protein; Provisional; Region: PRK08244 481743015640 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 481743015641 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 481743015642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743015643 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743015644 putative substrate translocation pore; other site 481743015645 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 481743015646 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 481743015647 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743015648 putative DNA binding site [nucleotide binding]; other site 481743015649 dimerization interface [polypeptide binding]; other site 481743015650 putative Zn2+ binding site [ion binding]; other site 481743015651 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743015652 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743015653 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 481743015654 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 481743015655 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 481743015656 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 481743015657 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 481743015658 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 481743015659 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 481743015660 ATP cone domain; Region: ATP-cone; pfam03477 481743015661 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 481743015662 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 481743015663 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 481743015664 N-acetyl-D-glucosamine binding site [chemical binding]; other site 481743015665 catalytic residue [active] 481743015666 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 481743015667 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 481743015668 CoA-binding site [chemical binding]; other site 481743015669 ATP-binding [chemical binding]; other site 481743015670 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 481743015671 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 481743015672 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 481743015673 DNA binding site [nucleotide binding] 481743015674 catalytic residue [active] 481743015675 H2TH interface [polypeptide binding]; other site 481743015676 putative catalytic residues [active] 481743015677 turnover-facilitating residue; other site 481743015678 intercalation triad [nucleotide binding]; other site 481743015679 8OG recognition residue [nucleotide binding]; other site 481743015680 putative reading head residues; other site 481743015681 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 481743015682 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 481743015683 DNA polymerase I; Provisional; Region: PRK05755 481743015684 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 481743015685 active site 481743015686 metal binding site 1 [ion binding]; metal-binding site 481743015687 putative 5' ssDNA interaction site; other site 481743015688 metal binding site 3; metal-binding site 481743015689 metal binding site 2 [ion binding]; metal-binding site 481743015690 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 481743015691 putative DNA binding site [nucleotide binding]; other site 481743015692 putative metal binding site [ion binding]; other site 481743015693 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 481743015694 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 481743015695 active site 481743015696 DNA binding site [nucleotide binding] 481743015697 catalytic site [active] 481743015698 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 481743015699 PhoU domain; Region: PhoU; pfam01895 481743015700 PhoU domain; Region: PhoU; pfam01895 481743015701 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 481743015702 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 481743015703 Walker A/P-loop; other site 481743015704 ATP binding site [chemical binding]; other site 481743015705 Q-loop/lid; other site 481743015706 ABC transporter signature motif; other site 481743015707 Walker B; other site 481743015708 D-loop; other site 481743015709 H-loop/switch region; other site 481743015710 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 481743015711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743015712 dimer interface [polypeptide binding]; other site 481743015713 conserved gate region; other site 481743015714 putative PBP binding loops; other site 481743015715 ABC-ATPase subunit interface; other site 481743015716 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 481743015717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743015718 dimer interface [polypeptide binding]; other site 481743015719 conserved gate region; other site 481743015720 putative PBP binding loops; other site 481743015721 ABC-ATPase subunit interface; other site 481743015722 PBP superfamily domain; Region: PBP_like_2; cl17296 481743015723 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 481743015724 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 481743015725 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 481743015726 dimer interface [polypeptide binding]; other site 481743015727 putative CheW interface [polypeptide binding]; other site 481743015728 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743015729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743015730 active site 481743015731 phosphorylation site [posttranslational modification] 481743015732 intermolecular recognition site; other site 481743015733 dimerization interface [polypeptide binding]; other site 481743015734 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743015735 DNA binding site [nucleotide binding] 481743015736 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 481743015737 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743015738 dimerization interface [polypeptide binding]; other site 481743015739 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 481743015740 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481743015741 putative active site [active] 481743015742 heme pocket [chemical binding]; other site 481743015743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743015744 dimer interface [polypeptide binding]; other site 481743015745 phosphorylation site [posttranslational modification] 481743015746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743015747 ATP binding site [chemical binding]; other site 481743015748 Mg2+ binding site [ion binding]; other site 481743015749 G-X-G motif; other site 481743015750 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 481743015751 Sodium Bile acid symporter family; Region: SBF; cl17470 481743015752 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 481743015753 Fumarase C-terminus; Region: Fumerase_C; pfam05683 481743015754 short chain dehydrogenase; Provisional; Region: PRK06701 481743015755 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 481743015756 NAD binding site [chemical binding]; other site 481743015757 metal binding site [ion binding]; metal-binding site 481743015758 active site 481743015759 malate dehydrogenase; Reviewed; Region: PRK06223 481743015760 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 481743015761 NAD(P) binding site [chemical binding]; other site 481743015762 dimer interface [polypeptide binding]; other site 481743015763 tetramer (dimer of dimers) interface [polypeptide binding]; other site 481743015764 substrate binding site [chemical binding]; other site 481743015765 isocitrate dehydrogenase; Reviewed; Region: PRK07006 481743015766 isocitrate dehydrogenase; Validated; Region: PRK06451 481743015767 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 481743015768 dimer interface [polypeptide binding]; other site 481743015769 Citrate synthase; Region: Citrate_synt; pfam00285 481743015770 active site 481743015771 citrylCoA binding site [chemical binding]; other site 481743015772 oxalacetate/citrate binding site [chemical binding]; other site 481743015773 coenzyme A binding site [chemical binding]; other site 481743015774 catalytic triad [active] 481743015775 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 481743015776 Domain of unknown function DUF20; Region: UPF0118; pfam01594 481743015777 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 481743015778 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 481743015779 active site 481743015780 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 481743015781 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 481743015782 domain interfaces; other site 481743015783 active site 481743015784 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 481743015785 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 481743015786 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 481743015787 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 481743015788 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 481743015789 tetramer interfaces [polypeptide binding]; other site 481743015790 binuclear metal-binding site [ion binding]; other site 481743015791 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 481743015792 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 481743015793 active site 481743015794 PHP Thumb interface [polypeptide binding]; other site 481743015795 metal binding site [ion binding]; metal-binding site 481743015796 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 481743015797 generic binding surface II; other site 481743015798 generic binding surface I; other site 481743015799 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 481743015800 YtpI-like protein; Region: YtpI; pfam14007 481743015801 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 481743015802 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743015803 DNA-binding site [nucleotide binding]; DNA binding site 481743015804 DRTGG domain; Region: DRTGG; pfam07085 481743015805 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 481743015806 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 481743015807 Protein of unknown function (DUF964); Region: DUF964; cl01483 481743015808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 481743015809 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 481743015810 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 481743015811 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 481743015812 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 481743015813 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 481743015814 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 481743015815 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 481743015816 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 481743015817 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743015818 motif II; other site 481743015819 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743015820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743015821 active site 481743015822 phosphorylation site [posttranslational modification] 481743015823 intermolecular recognition site; other site 481743015824 dimerization interface [polypeptide binding]; other site 481743015825 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743015826 DNA binding site [nucleotide binding] 481743015827 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743015828 dimerization interface [polypeptide binding]; other site 481743015829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743015830 dimer interface [polypeptide binding]; other site 481743015831 phosphorylation site [posttranslational modification] 481743015832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743015833 ATP binding site [chemical binding]; other site 481743015834 Mg2+ binding site [ion binding]; other site 481743015835 G-X-G motif; other site 481743015836 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 481743015837 dimanganese center [ion binding]; other site 481743015838 CotJB protein; Region: CotJB; pfam12652 481743015839 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 481743015840 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 481743015841 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 481743015842 Domain of unknown function DUF21; Region: DUF21; pfam01595 481743015843 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 481743015844 Transporter associated domain; Region: CorC_HlyC; smart01091 481743015845 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 481743015846 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743015847 FeS/SAM binding site; other site 481743015848 YfkB-like domain; Region: YfkB; pfam08756 481743015849 MMPL family; Region: MMPL; pfam03176 481743015850 MMPL family; Region: MMPL; pfam03176 481743015851 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 481743015852 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 481743015853 Zn2+ binding site [ion binding]; other site 481743015854 Mg2+ binding site [ion binding]; other site 481743015855 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 481743015856 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 481743015857 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 481743015858 active site 481743015859 metal binding site [ion binding]; metal-binding site 481743015860 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 481743015861 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 481743015862 MoaE interaction surface [polypeptide binding]; other site 481743015863 MoeB interaction surface [polypeptide binding]; other site 481743015864 thiocarboxylated glycine; other site 481743015865 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 481743015866 MoaE homodimer interface [polypeptide binding]; other site 481743015867 MoaD interaction [polypeptide binding]; other site 481743015868 active site residues [active] 481743015869 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 481743015870 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 481743015871 Zn2+ binding site [ion binding]; other site 481743015872 Mg2+ binding site [ion binding]; other site 481743015873 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 481743015874 FeS assembly protein SufB; Region: sufB; TIGR01980 481743015875 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 481743015876 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 481743015877 trimerization site [polypeptide binding]; other site 481743015878 active site 481743015879 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 481743015880 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 481743015881 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 481743015882 catalytic residue [active] 481743015883 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 481743015884 FeS assembly protein SufD; Region: sufD; TIGR01981 481743015885 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 481743015886 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 481743015887 Walker A/P-loop; other site 481743015888 ATP binding site [chemical binding]; other site 481743015889 Q-loop/lid; other site 481743015890 ABC transporter signature motif; other site 481743015891 Walker B; other site 481743015892 D-loop; other site 481743015893 H-loop/switch region; other site 481743015894 Ferritin-like domain; Region: Ferritin; pfam00210 481743015895 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 481743015896 dimerization interface [polypeptide binding]; other site 481743015897 DPS ferroxidase diiron center [ion binding]; other site 481743015898 ion pore; other site 481743015899 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 481743015900 Phosphotransferase enzyme family; Region: APH; pfam01636 481743015901 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 481743015902 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 481743015903 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 481743015904 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 481743015905 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 481743015906 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 481743015907 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 481743015908 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 481743015909 catalytic triad [active] 481743015910 catalytic triad [active] 481743015911 oxyanion hole [active] 481743015912 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 481743015913 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 481743015914 active site residue [active] 481743015915 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 481743015916 active site residue [active] 481743015917 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 481743015918 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481743015919 non-specific DNA binding site [nucleotide binding]; other site 481743015920 salt bridge; other site 481743015921 sequence-specific DNA binding site [nucleotide binding]; other site 481743015922 DinB family; Region: DinB; cl17821 481743015923 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 481743015924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743015925 putative substrate translocation pore; other site 481743015926 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 481743015927 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 481743015928 short chain dehydrogenase; Provisional; Region: PRK12747 481743015929 NADP binding site [chemical binding]; other site 481743015930 homodimer interface [polypeptide binding]; other site 481743015931 active site 481743015932 substrate binding site [chemical binding]; other site 481743015933 Uncharacterized conserved protein [Function unknown]; Region: COG1284 481743015934 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 481743015935 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 481743015936 glutamate dehydrogenase; Provisional; Region: PRK09414 481743015937 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 481743015938 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 481743015939 NAD(P) binding site [chemical binding]; other site 481743015940 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 481743015941 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl17742 481743015942 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 481743015943 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 481743015944 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 481743015945 classical (c) SDRs; Region: SDR_c; cd05233 481743015946 NAD(P) binding site [chemical binding]; other site 481743015947 active site 481743015948 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 481743015949 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743015950 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743015951 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 481743015952 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 481743015953 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 481743015954 HTH domain; Region: HTH_11; pfam08279 481743015955 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 481743015956 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 481743015957 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 481743015958 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 481743015959 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 481743015960 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 481743015961 classical (c) SDRs; Region: SDR_c; cd05233 481743015962 NAD(P) binding site [chemical binding]; other site 481743015963 active site 481743015964 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743015965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743015966 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 481743015967 dimerization interface [polypeptide binding]; other site 481743015968 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 481743015969 active site 481743015970 putative catalytic site [active] 481743015971 DNA binding site [nucleotide binding] 481743015972 putative phosphate binding site [ion binding]; other site 481743015973 metal binding site A [ion binding]; metal-binding site 481743015974 AP binding site [nucleotide binding]; other site 481743015975 metal binding site B [ion binding]; metal-binding site 481743015976 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 481743015977 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743015978 active site 481743015979 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 481743015980 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743015981 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 481743015982 DNA binding residues [nucleotide binding] 481743015983 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 481743015984 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 481743015985 putative ligand binding residues [chemical binding]; other site 481743015986 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 481743015987 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481743015988 ABC-ATPase subunit interface; other site 481743015989 dimer interface [polypeptide binding]; other site 481743015990 putative PBP binding regions; other site 481743015991 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 481743015992 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481743015993 ABC-ATPase subunit interface; other site 481743015994 dimer interface [polypeptide binding]; other site 481743015995 putative PBP binding regions; other site 481743015996 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 481743015997 FtsX-like permease family; Region: FtsX; pfam02687 481743015998 FtsX-like permease family; Region: FtsX; pfam02687 481743015999 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 481743016000 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 481743016001 Walker A/P-loop; other site 481743016002 ATP binding site [chemical binding]; other site 481743016003 Q-loop/lid; other site 481743016004 ABC transporter signature motif; other site 481743016005 Walker B; other site 481743016006 D-loop; other site 481743016007 H-loop/switch region; other site 481743016008 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 481743016009 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 481743016010 putative NAD(P) binding site [chemical binding]; other site 481743016011 catalytic Zn binding site [ion binding]; other site 481743016012 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743016013 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743016014 DNA binding site [nucleotide binding] 481743016015 domain linker motif; other site 481743016016 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743016017 ligand binding site [chemical binding]; other site 481743016018 dimerization interface [polypeptide binding]; other site 481743016019 DinB family; Region: DinB; cl17821 481743016020 DinB superfamily; Region: DinB_2; pfam12867 481743016021 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 481743016022 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 481743016023 NAD binding site [chemical binding]; other site 481743016024 sugar binding site [chemical binding]; other site 481743016025 divalent metal binding site [ion binding]; other site 481743016026 tetramer (dimer of dimers) interface [polypeptide binding]; other site 481743016027 dimer interface [polypeptide binding]; other site 481743016028 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 481743016029 nucleotide binding site [chemical binding]; other site 481743016030 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743016031 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743016032 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743016033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743016034 dimer interface [polypeptide binding]; other site 481743016035 conserved gate region; other site 481743016036 putative PBP binding loops; other site 481743016037 ABC-ATPase subunit interface; other site 481743016038 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743016039 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 481743016040 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743016041 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743016042 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743016043 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743016044 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 481743016045 active site 481743016046 active site 481743016047 catalytic residues [active] 481743016048 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743016049 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743016050 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743016051 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 481743016052 Cupin domain; Region: Cupin_2; cl17218 481743016053 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743016054 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743016055 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 481743016056 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 481743016057 active site residue [active] 481743016058 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 481743016059 active site residue [active] 481743016060 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 481743016061 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 481743016062 Walker A/P-loop; other site 481743016063 ATP binding site [chemical binding]; other site 481743016064 Q-loop/lid; other site 481743016065 ABC transporter signature motif; other site 481743016066 Walker B; other site 481743016067 D-loop; other site 481743016068 H-loop/switch region; other site 481743016069 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 481743016070 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481743016071 membrane-bound complex binding site; other site 481743016072 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 481743016073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743016074 dimer interface [polypeptide binding]; other site 481743016075 conserved gate region; other site 481743016076 ABC-ATPase subunit interface; other site 481743016077 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 481743016078 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 481743016079 active site 481743016080 non-prolyl cis peptide bond; other site 481743016081 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481743016082 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481743016083 active site 481743016084 catalytic tetrad [active] 481743016085 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 481743016086 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 481743016087 active site 481743016088 non-prolyl cis peptide bond; other site 481743016089 Predicted transcriptional regulators [Transcription]; Region: COG1695 481743016090 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 481743016091 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 481743016092 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 481743016093 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 481743016094 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 481743016095 Spore germination protein; Region: Spore_permease; cl17796 481743016096 Predicted membrane protein [Function unknown]; Region: COG2323 481743016097 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 481743016098 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 481743016099 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 481743016100 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 481743016101 substrate binding site [chemical binding]; other site 481743016102 ATP binding site [chemical binding]; other site 481743016103 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 481743016104 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 481743016105 active site 481743016106 intersubunit interface [polypeptide binding]; other site 481743016107 catalytic residue [active] 481743016108 Uncharacterized conserved protein [Function unknown]; Region: COG1284 481743016109 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 481743016110 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 481743016111 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 481743016112 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 481743016113 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 481743016114 active site 481743016115 phosphorylation site [posttranslational modification] 481743016116 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 481743016117 active site 481743016118 P-loop; other site 481743016119 phosphorylation site [posttranslational modification] 481743016120 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 481743016121 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 481743016122 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 481743016123 putative substrate binding site [chemical binding]; other site 481743016124 putative ATP binding site [chemical binding]; other site 481743016125 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 481743016126 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 481743016127 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 481743016128 EDD domain protein, DegV family; Region: DegV; TIGR00762 481743016129 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 481743016130 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 481743016131 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 481743016132 putative active site [active] 481743016133 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 481743016134 HTH domain; Region: HTH_11; pfam08279 481743016135 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 481743016136 FOG: CBS domain [General function prediction only]; Region: COG0517 481743016137 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 481743016138 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 481743016139 Cation efflux family; Region: Cation_efflux; pfam01545 481743016140 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 481743016141 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 481743016142 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 481743016143 SpoVR like protein; Region: SpoVR; pfam04293 481743016144 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 481743016145 heme-binding site [chemical binding]; other site 481743016146 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 481743016147 dimer interface [polypeptide binding]; other site 481743016148 putative CheW interface [polypeptide binding]; other site 481743016149 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 481743016150 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 481743016151 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 481743016152 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743016153 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 481743016154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743016155 homodimer interface [polypeptide binding]; other site 481743016156 catalytic residue [active] 481743016157 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743016158 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743016159 DNA binding residues [nucleotide binding] 481743016160 dimerization interface [polypeptide binding]; other site 481743016161 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 481743016162 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 481743016163 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 481743016164 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 481743016165 homodimer interface [polypeptide binding]; other site 481743016166 substrate-cofactor binding pocket; other site 481743016167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743016168 catalytic residue [active] 481743016169 N-terminal-like domain of Paenibacillus sp. YM-1 Laminaribiose Phosphorylase and similar proteins; Region: GH94N_LBP_like; cd11749 481743016170 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 481743016171 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743016172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743016173 dimer interface [polypeptide binding]; other site 481743016174 conserved gate region; other site 481743016175 putative PBP binding loops; other site 481743016176 ABC-ATPase subunit interface; other site 481743016177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743016178 dimer interface [polypeptide binding]; other site 481743016179 conserved gate region; other site 481743016180 putative PBP binding loops; other site 481743016181 ABC-ATPase subunit interface; other site 481743016182 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743016183 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743016184 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743016185 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743016186 DNA binding site [nucleotide binding] 481743016187 domain linker motif; other site 481743016188 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743016189 dimerization interface [polypeptide binding]; other site 481743016190 ligand binding site [chemical binding]; other site 481743016191 glutamine synthetase, type I; Region: GlnA; TIGR00653 481743016192 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 481743016193 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 481743016194 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 481743016195 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 481743016196 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743016197 Histidine kinase; Region: His_kinase; pfam06580 481743016198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743016199 ATP binding site [chemical binding]; other site 481743016200 Mg2+ binding site [ion binding]; other site 481743016201 G-X-G motif; other site 481743016202 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 481743016203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743016204 active site 481743016205 phosphorylation site [posttranslational modification] 481743016206 intermolecular recognition site; other site 481743016207 dimerization interface [polypeptide binding]; other site 481743016208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743016209 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 481743016210 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743016211 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743016212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743016213 dimer interface [polypeptide binding]; other site 481743016214 conserved gate region; other site 481743016215 putative PBP binding loops; other site 481743016216 ABC-ATPase subunit interface; other site 481743016217 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743016218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743016219 dimer interface [polypeptide binding]; other site 481743016220 conserved gate region; other site 481743016221 ABC-ATPase subunit interface; other site 481743016222 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 481743016223 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 481743016224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743016225 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743016226 dimerization interface [polypeptide binding]; other site 481743016227 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743016228 dimer interface [polypeptide binding]; other site 481743016229 phosphorylation site [posttranslational modification] 481743016230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743016231 ATP binding site [chemical binding]; other site 481743016232 Mg2+ binding site [ion binding]; other site 481743016233 G-X-G motif; other site 481743016234 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743016235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743016236 active site 481743016237 phosphorylation site [posttranslational modification] 481743016238 intermolecular recognition site; other site 481743016239 dimerization interface [polypeptide binding]; other site 481743016240 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743016241 DNA binding site [nucleotide binding] 481743016242 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 481743016243 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 481743016244 protein binding site [polypeptide binding]; other site 481743016245 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743016246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743016247 active site 481743016248 phosphorylation site [posttranslational modification] 481743016249 intermolecular recognition site; other site 481743016250 dimerization interface [polypeptide binding]; other site 481743016251 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743016252 DNA binding residues [nucleotide binding] 481743016253 dimerization interface [polypeptide binding]; other site 481743016254 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 481743016255 HAMP domain; Region: HAMP; pfam00672 481743016256 dimerization interface [polypeptide binding]; other site 481743016257 Histidine kinase; Region: HisKA_3; pfam07730 481743016258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743016259 ATP binding site [chemical binding]; other site 481743016260 Mg2+ binding site [ion binding]; other site 481743016261 G-X-G motif; other site 481743016262 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 481743016263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 481743016264 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 481743016265 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 481743016266 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 481743016267 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 481743016268 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 481743016269 active site 481743016270 dimer interface [polypeptide binding]; other site 481743016271 motif 1; other site 481743016272 motif 2; other site 481743016273 motif 3; other site 481743016274 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 481743016275 anticodon binding site; other site 481743016276 YtxC-like family; Region: YtxC; pfam08812 481743016277 Transposase IS200 like; Region: Y1_Tnp; pfam01797 481743016278 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 481743016279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743016280 FeS/SAM binding site; other site 481743016281 cystathionine beta-lyase; Provisional; Region: PRK08064 481743016282 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 481743016283 homodimer interface [polypeptide binding]; other site 481743016284 substrate-cofactor binding pocket; other site 481743016285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743016286 catalytic residue [active] 481743016287 cystathionine gamma-synthase; Reviewed; Region: PRK08247 481743016288 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 481743016289 homodimer interface [polypeptide binding]; other site 481743016290 substrate-cofactor binding pocket; other site 481743016291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743016292 catalytic residue [active] 481743016293 Homoserine O-succinyltransferase; Region: HTS; pfam04204 481743016294 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 481743016295 proposed active site lysine [active] 481743016296 conserved cys residue [active] 481743016297 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 481743016298 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 481743016299 oligomer interface [polypeptide binding]; other site 481743016300 metal binding site [ion binding]; metal-binding site 481743016301 metal binding site [ion binding]; metal-binding site 481743016302 putative Cl binding site [ion binding]; other site 481743016303 aspartate ring; other site 481743016304 basic sphincter; other site 481743016305 hydrophobic gate; other site 481743016306 periplasmic entrance; other site 481743016307 HRDC domain; Region: HRDC; pfam00570 481743016308 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 481743016309 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 481743016310 nucleotide binding site [chemical binding]; other site 481743016311 5'-3' exonuclease; Region: 53EXOc; smart00475 481743016312 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 481743016313 active site 481743016314 metal binding site 1 [ion binding]; metal-binding site 481743016315 putative 5' ssDNA interaction site; other site 481743016316 metal binding site 3; metal-binding site 481743016317 metal binding site 2 [ion binding]; metal-binding site 481743016318 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 481743016319 putative DNA binding site [nucleotide binding]; other site 481743016320 putative metal binding site [ion binding]; other site 481743016321 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 481743016322 ArsC family; Region: ArsC; pfam03960 481743016323 putative ArsC-like catalytic residues; other site 481743016324 putative TRX-like catalytic residues [active] 481743016325 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 481743016326 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 481743016327 RNA binding surface [nucleotide binding]; other site 481743016328 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 481743016329 active site 481743016330 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 481743016331 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 481743016332 hypothetical protein; Validated; Region: PRK07682 481743016333 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743016334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743016335 homodimer interface [polypeptide binding]; other site 481743016336 catalytic residue [active] 481743016337 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 481743016338 AsnC family; Region: AsnC_trans_reg; pfam01037 481743016339 Coat F domain; Region: Coat_F; pfam07875 481743016340 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 481743016341 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 481743016342 Predicted membrane protein [Function unknown]; Region: COG3766 481743016343 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 481743016344 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 481743016345 MutS domain III; Region: MutS_III; pfam05192 481743016346 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 481743016347 Walker A/P-loop; other site 481743016348 ATP binding site [chemical binding]; other site 481743016349 Q-loop/lid; other site 481743016350 ABC transporter signature motif; other site 481743016351 Walker B; other site 481743016352 D-loop; other site 481743016353 H-loop/switch region; other site 481743016354 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 481743016355 Smr domain; Region: Smr; pfam01713 481743016356 Membrane protein of unknown function; Region: DUF360; pfam04020 481743016357 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 481743016358 Cell division protein ZapA; Region: ZapA; cl01146 481743016359 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 481743016360 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 481743016361 putative tRNA-binding site [nucleotide binding]; other site 481743016362 B3/4 domain; Region: B3_4; pfam03483 481743016363 tRNA synthetase B5 domain; Region: B5; smart00874 481743016364 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 481743016365 dimer interface [polypeptide binding]; other site 481743016366 motif 1; other site 481743016367 motif 3; other site 481743016368 motif 2; other site 481743016369 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 481743016370 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 481743016371 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 481743016372 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 481743016373 dimer interface [polypeptide binding]; other site 481743016374 motif 1; other site 481743016375 active site 481743016376 motif 2; other site 481743016377 motif 3; other site 481743016378 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 481743016379 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481743016380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743016381 Walker A/P-loop; other site 481743016382 ATP binding site [chemical binding]; other site 481743016383 Q-loop/lid; other site 481743016384 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481743016385 ABC transporter signature motif; other site 481743016386 Walker B; other site 481743016387 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481743016388 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 481743016389 active site 481743016390 catalytic residues [active] 481743016391 metal binding site [ion binding]; metal-binding site 481743016392 multifunctional aminopeptidase A; Provisional; Region: PRK00913 481743016393 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 481743016394 interface (dimer of trimers) [polypeptide binding]; other site 481743016395 Substrate-binding/catalytic site; other site 481743016396 Zn-binding sites [ion binding]; other site 481743016397 PAS domain; Region: PAS; smart00091 481743016398 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 481743016399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743016400 dimer interface [polypeptide binding]; other site 481743016401 phosphorylation site [posttranslational modification] 481743016402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743016403 ATP binding site [chemical binding]; other site 481743016404 Mg2+ binding site [ion binding]; other site 481743016405 G-X-G motif; other site 481743016406 peroxiredoxin; Region: AhpC; TIGR03137 481743016407 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 481743016408 dimer interface [polypeptide binding]; other site 481743016409 decamer (pentamer of dimers) interface [polypeptide binding]; other site 481743016410 catalytic triad [active] 481743016411 peroxidatic and resolving cysteines [active] 481743016412 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 481743016413 tartrate dehydrogenase; Region: TTC; TIGR02089 481743016414 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481743016415 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481743016416 active site 481743016417 catalytic tetrad [active] 481743016418 2-isopropylmalate synthase; Validated; Region: PRK00915 481743016419 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 481743016420 active site 481743016421 catalytic residues [active] 481743016422 metal binding site [ion binding]; metal-binding site 481743016423 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 481743016424 ketol-acid reductoisomerase; Provisional; Region: PRK05479 481743016425 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 481743016426 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 481743016427 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 481743016428 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 481743016429 putative valine binding site [chemical binding]; other site 481743016430 dimer interface [polypeptide binding]; other site 481743016431 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 481743016432 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 481743016433 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 481743016434 PYR/PP interface [polypeptide binding]; other site 481743016435 dimer interface [polypeptide binding]; other site 481743016436 TPP binding site [chemical binding]; other site 481743016437 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 481743016438 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 481743016439 TPP-binding site [chemical binding]; other site 481743016440 dimer interface [polypeptide binding]; other site 481743016441 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743016442 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 481743016443 Coenzyme A binding pocket [chemical binding]; other site 481743016444 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 481743016445 23S rRNA binding site [nucleotide binding]; other site 481743016446 L21 binding site [polypeptide binding]; other site 481743016447 L13 binding site [polypeptide binding]; other site 481743016448 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 481743016449 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 481743016450 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 481743016451 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 481743016452 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 481743016453 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 481743016454 DXD motif; other site 481743016455 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 481743016456 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 481743016457 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 481743016458 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 481743016459 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 481743016460 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743016461 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 481743016462 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 481743016463 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 481743016464 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 481743016465 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 481743016466 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 481743016467 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481743016468 ATP binding site [chemical binding]; other site 481743016469 putative Mg++ binding site [ion binding]; other site 481743016470 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481743016471 nucleotide binding region [chemical binding]; other site 481743016472 ATP-binding site [chemical binding]; other site 481743016473 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 481743016474 HRDC domain; Region: HRDC; pfam00570 481743016475 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743016476 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743016477 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743016478 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 481743016479 putative hydrophobic ligand binding site [chemical binding]; other site 481743016480 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 481743016481 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743016482 active site 481743016483 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 481743016484 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 481743016485 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 481743016486 metal binding site [ion binding]; metal-binding site 481743016487 active site 481743016488 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 481743016489 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743016490 dimerization interface [polypeptide binding]; other site 481743016491 putative DNA binding site [nucleotide binding]; other site 481743016492 putative Zn2+ binding site [ion binding]; other site 481743016493 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 481743016494 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 481743016495 putative metal binding site [ion binding]; other site 481743016496 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 481743016497 active site 481743016498 Predicted transcriptional regulator [Transcription]; Region: COG1959 481743016499 Transcriptional regulator; Region: Rrf2; pfam02082 481743016500 Predicted permeases [General function prediction only]; Region: COG0679 481743016501 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 481743016502 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 481743016503 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743016504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743016505 dimer interface [polypeptide binding]; other site 481743016506 phosphorylation site [posttranslational modification] 481743016507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743016508 ATP binding site [chemical binding]; other site 481743016509 Mg2+ binding site [ion binding]; other site 481743016510 G-X-G motif; other site 481743016511 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 481743016512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743016513 active site 481743016514 phosphorylation site [posttranslational modification] 481743016515 intermolecular recognition site; other site 481743016516 dimerization interface [polypeptide binding]; other site 481743016517 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743016518 Histidine kinase; Region: His_kinase; pfam06580 481743016519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743016520 ATP binding site [chemical binding]; other site 481743016521 Mg2+ binding site [ion binding]; other site 481743016522 G-X-G motif; other site 481743016523 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 481743016524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743016525 active site 481743016526 phosphorylation site [posttranslational modification] 481743016527 intermolecular recognition site; other site 481743016528 dimerization interface [polypeptide binding]; other site 481743016529 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 481743016530 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 481743016531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743016532 Coenzyme A binding pocket [chemical binding]; other site 481743016533 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 481743016534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743016535 Coenzyme A binding pocket [chemical binding]; other site 481743016536 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 481743016537 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 481743016538 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 481743016539 active site 481743016540 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 481743016541 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 481743016542 cobalamin synthase; Reviewed; Region: cobS; PRK00235 481743016543 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 481743016544 homotrimer interface [polypeptide binding]; other site 481743016545 Walker A motif; other site 481743016546 GTP binding site [chemical binding]; other site 481743016547 Walker B motif; other site 481743016548 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 481743016549 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 481743016550 putative dimer interface [polypeptide binding]; other site 481743016551 active site pocket [active] 481743016552 putative cataytic base [active] 481743016553 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 481743016554 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 481743016555 Walker A/P-loop; other site 481743016556 ATP binding site [chemical binding]; other site 481743016557 Q-loop/lid; other site 481743016558 ABC transporter signature motif; other site 481743016559 Walker B; other site 481743016560 D-loop; other site 481743016561 H-loop/switch region; other site 481743016562 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 481743016563 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481743016564 ABC-ATPase subunit interface; other site 481743016565 dimer interface [polypeptide binding]; other site 481743016566 putative PBP binding regions; other site 481743016567 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 481743016568 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 481743016569 intersubunit interface [polypeptide binding]; other site 481743016570 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 481743016571 catalytic core [active] 481743016572 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 481743016573 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 481743016574 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 481743016575 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 481743016576 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743016577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743016578 homodimer interface [polypeptide binding]; other site 481743016579 catalytic residue [active] 481743016580 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 481743016581 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 481743016582 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 481743016583 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 481743016584 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 481743016585 EamA-like transporter family; Region: EamA; pfam00892 481743016586 EamA-like transporter family; Region: EamA; pfam00892 481743016587 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 481743016588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743016589 active site 481743016590 motif I; other site 481743016591 motif II; other site 481743016592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743016593 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 481743016594 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 481743016595 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 481743016596 DNA binding residues [nucleotide binding] 481743016597 putative dimer interface [polypeptide binding]; other site 481743016598 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 481743016599 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 481743016600 DNA binding residues [nucleotide binding] 481743016601 putative dimer interface [polypeptide binding]; other site 481743016602 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 481743016603 putative hydrolase; Provisional; Region: PRK02113 481743016604 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 481743016605 Serpin (serine protease inhibitor); Region: Serpin; pfam00079 481743016606 serpin-like protein; Provisional; Region: PHA02660 481743016607 reactive center loop; other site 481743016608 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 481743016609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 481743016610 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 481743016611 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 481743016612 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 481743016613 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 481743016614 Walker A/P-loop; other site 481743016615 ATP binding site [chemical binding]; other site 481743016616 Q-loop/lid; other site 481743016617 ABC transporter signature motif; other site 481743016618 Walker B; other site 481743016619 D-loop; other site 481743016620 H-loop/switch region; other site 481743016621 TOBE domain; Region: TOBE_2; pfam08402 481743016622 sulfate transport protein; Provisional; Region: cysT; CHL00187 481743016623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743016624 dimer interface [polypeptide binding]; other site 481743016625 conserved gate region; other site 481743016626 putative PBP binding loops; other site 481743016627 ABC-ATPase subunit interface; other site 481743016628 sulfate transport protein; Provisional; Region: cysT; CHL00187 481743016629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743016630 dimer interface [polypeptide binding]; other site 481743016631 conserved gate region; other site 481743016632 putative PBP binding loops; other site 481743016633 ABC-ATPase subunit interface; other site 481743016634 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 481743016635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743016636 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743016637 WHG domain; Region: WHG; pfam13305 481743016638 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 481743016639 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 481743016640 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 481743016641 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 481743016642 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 481743016643 active site 481743016644 dimer interface [polypeptide binding]; other site 481743016645 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 481743016646 dimer interface [polypeptide binding]; other site 481743016647 active site 481743016648 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 481743016649 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 481743016650 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743016651 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 481743016652 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 481743016653 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 481743016654 TPP-binding site [chemical binding]; other site 481743016655 dimer interface [polypeptide binding]; other site 481743016656 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 481743016657 PYR/PP interface [polypeptide binding]; other site 481743016658 dimer interface [polypeptide binding]; other site 481743016659 TPP binding site [chemical binding]; other site 481743016660 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 481743016661 metal ion-dependent adhesion site (MIDAS); other site 481743016662 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 481743016663 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 481743016664 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 481743016665 metal ion-dependent adhesion site (MIDAS); other site 481743016666 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 481743016667 von Willebrand factor type A domain; Region: VWA_2; pfam13519 481743016668 metal ion-dependent adhesion site (MIDAS); other site 481743016669 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 481743016670 Protein of unknown function DUF58; Region: DUF58; pfam01882 481743016671 MoxR-like ATPases [General function prediction only]; Region: COG0714 481743016672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743016673 Walker A motif; other site 481743016674 ATP binding site [chemical binding]; other site 481743016675 Walker B motif; other site 481743016676 arginine finger; other site 481743016677 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 481743016678 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 481743016679 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743016680 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481743016681 Walker A/P-loop; other site 481743016682 ATP binding site [chemical binding]; other site 481743016683 Q-loop/lid; other site 481743016684 ABC transporter signature motif; other site 481743016685 Walker B; other site 481743016686 D-loop; other site 481743016687 H-loop/switch region; other site 481743016688 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 481743016689 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 481743016690 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 481743016691 putative active site [active] 481743016692 putative substrate binding site [chemical binding]; other site 481743016693 putative cosubstrate binding site; other site 481743016694 catalytic site [active] 481743016695 endonuclease IV; Provisional; Region: PRK01060 481743016696 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 481743016697 AP (apurinic/apyrimidinic) site pocket; other site 481743016698 DNA interaction; other site 481743016699 Metal-binding active site; metal-binding site 481743016700 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 481743016701 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743016702 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743016703 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 481743016704 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 481743016705 phosphopeptide binding site; other site 481743016706 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 481743016707 Snf7; Region: Snf7; pfam03357 481743016708 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 481743016709 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 481743016710 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 481743016711 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 481743016712 ATP binding site [chemical binding]; other site 481743016713 Walker A motif; other site 481743016714 hexamer interface [polypeptide binding]; other site 481743016715 Walker B motif; other site 481743016716 AAA domain; Region: AAA_31; pfam13614 481743016717 Staphylococcal nuclease homologues; Region: SNc; smart00318 481743016718 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 481743016719 Catalytic site; other site 481743016720 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 481743016721 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 481743016722 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 481743016723 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 481743016724 YtkA-like; Region: YtkA; pfam13115 481743016725 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 481743016726 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 481743016727 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 481743016728 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481743016729 non-specific DNA binding site [nucleotide binding]; other site 481743016730 salt bridge; other site 481743016731 sequence-specific DNA binding site [nucleotide binding]; other site 481743016732 PAS domain; Region: PAS_9; pfam13426 481743016733 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 481743016734 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 481743016735 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 481743016736 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481743016737 ABC-ATPase subunit interface; other site 481743016738 dimer interface [polypeptide binding]; other site 481743016739 putative PBP binding regions; other site 481743016740 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 481743016741 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481743016742 ABC-ATPase subunit interface; other site 481743016743 dimer interface [polypeptide binding]; other site 481743016744 putative PBP binding regions; other site 481743016745 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 481743016746 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 481743016747 intersubunit interface [polypeptide binding]; other site 481743016748 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743016749 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743016750 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 481743016751 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 481743016752 intersubunit interface [polypeptide binding]; other site 481743016753 General stress protein [General function prediction only]; Region: GsiB; COG3729 481743016754 General stress protein [General function prediction only]; Region: GsiB; COG3729 481743016755 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 481743016756 active site pocket [active] 481743016757 oxyanion hole [active] 481743016758 catalytic triad [active] 481743016759 active site nucleophile [active] 481743016760 Homeodomain-like domain; Region: HTH_23; cl17451 481743016761 Helix-turn-helix domain; Region: HTH_28; pfam13518 481743016762 putative transposase OrfB; Reviewed; Region: PHA02517 481743016763 HTH-like domain; Region: HTH_21; pfam13276 481743016764 Integrase core domain; Region: rve; pfam00665 481743016765 Integrase core domain; Region: rve_2; pfam13333 481743016766 SprT homologues; Region: SprT; cl01182 481743016767 hypothetical protein; Provisional; Region: PRK04351 481743016768 DinB superfamily; Region: DinB_2; pfam12867 481743016769 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 481743016770 CGNR zinc finger; Region: zf-CGNR; pfam11706 481743016771 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 481743016772 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 481743016773 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 481743016774 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 481743016775 RNA binding site [nucleotide binding]; other site 481743016776 PemK-like protein; Region: PemK; pfam02452 481743016777 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 481743016778 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 481743016779 alanine racemase; Reviewed; Region: alr; PRK00053 481743016780 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 481743016781 active site 481743016782 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 481743016783 dimer interface [polypeptide binding]; other site 481743016784 substrate binding site [chemical binding]; other site 481743016785 catalytic residues [active] 481743016786 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 481743016787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743016788 H+ Antiporter protein; Region: 2A0121; TIGR00900 481743016789 putative substrate translocation pore; other site 481743016790 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743016791 dimerization interface [polypeptide binding]; other site 481743016792 putative DNA binding site [nucleotide binding]; other site 481743016793 putative Zn2+ binding site [ion binding]; other site 481743016794 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 481743016795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743016796 Coenzyme A binding pocket [chemical binding]; other site 481743016797 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 481743016798 Predicted transcriptional regulators [Transcription]; Region: COG1510 481743016799 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 481743016800 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 481743016801 Walker A/P-loop; other site 481743016802 ATP binding site [chemical binding]; other site 481743016803 Q-loop/lid; other site 481743016804 ABC transporter signature motif; other site 481743016805 Walker B; other site 481743016806 D-loop; other site 481743016807 H-loop/switch region; other site 481743016808 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 481743016809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743016810 dimer interface [polypeptide binding]; other site 481743016811 conserved gate region; other site 481743016812 putative PBP binding loops; other site 481743016813 ABC-ATPase subunit interface; other site 481743016814 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 481743016815 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 481743016816 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 481743016817 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 481743016818 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 481743016819 UbiA prenyltransferase family; Region: UbiA; pfam01040 481743016820 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743016821 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743016822 DNA binding site [nucleotide binding] 481743016823 domain linker motif; other site 481743016824 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 481743016825 putative dimerization interface [polypeptide binding]; other site 481743016826 putative ligand binding site [chemical binding]; other site 481743016827 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 481743016828 hypothetical protein; Provisional; Region: PRK02399 481743016829 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 481743016830 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 481743016831 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743016832 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743016833 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 481743016834 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 481743016835 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 481743016836 YmaF family; Region: YmaF; pfam12788 481743016837 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 481743016838 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 481743016839 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743016840 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743016841 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 481743016842 dimerization interface [polypeptide binding]; other site 481743016843 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 481743016844 Zn2+ binding site [ion binding]; other site 481743016845 Mg2+ binding site [ion binding]; other site 481743016846 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 481743016847 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 481743016848 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 481743016849 ring oligomerisation interface [polypeptide binding]; other site 481743016850 ATP/Mg binding site [chemical binding]; other site 481743016851 stacking interactions; other site 481743016852 hinge regions; other site 481743016853 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 481743016854 oligomerisation interface [polypeptide binding]; other site 481743016855 mobile loop; other site 481743016856 roof hairpin; other site 481743016857 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 481743016858 Predicted transcriptional regulator [Transcription]; Region: COG2378 481743016859 WYL domain; Region: WYL; pfam13280 481743016860 WYL domain; Region: WYL; pfam13280 481743016861 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 481743016862 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 481743016863 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 481743016864 MPT binding site; other site 481743016865 trimer interface [polypeptide binding]; other site 481743016866 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 481743016867 trimer interface [polypeptide binding]; other site 481743016868 dimer interface [polypeptide binding]; other site 481743016869 putative active site [active] 481743016870 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 481743016871 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 481743016872 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 481743016873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743016874 Walker A/P-loop; other site 481743016875 ATP binding site [chemical binding]; other site 481743016876 Q-loop/lid; other site 481743016877 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481743016878 ABC transporter signature motif; other site 481743016879 Walker B; other site 481743016880 D-loop; other site 481743016881 ABC transporter; Region: ABC_tran_2; pfam12848 481743016882 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481743016883 2-isopropylmalate synthase; Validated; Region: PRK00915 481743016884 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 481743016885 active site 481743016886 catalytic residues [active] 481743016887 metal binding site [ion binding]; metal-binding site 481743016888 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 481743016889 UGMP family protein; Validated; Region: PRK09604 481743016890 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 481743016891 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 481743016892 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 481743016893 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743016894 Coenzyme A binding pocket [chemical binding]; other site 481743016895 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 481743016896 Glycoprotease family; Region: Peptidase_M22; pfam00814 481743016897 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 481743016898 Small acid-soluble spore protein H family; Region: SspH; cl06949 481743016899 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 481743016900 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 481743016901 putative DNA binding site [nucleotide binding]; other site 481743016902 putative homodimer interface [polypeptide binding]; other site 481743016903 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 481743016904 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 481743016905 active site 481743016906 DNA binding site [nucleotide binding] 481743016907 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 481743016908 DNA binding site [nucleotide binding] 481743016909 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 481743016910 nucleotide binding site [chemical binding]; other site 481743016911 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743016912 Radical SAM superfamily; Region: Radical_SAM; pfam04055 481743016913 FeS/SAM binding site; other site 481743016914 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743016915 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743016916 WHG domain; Region: WHG; pfam13305 481743016917 Beta-lactamase; Region: Beta-lactamase; pfam00144 481743016918 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 481743016919 Uncharacterized conserved protein [Function unknown]; Region: COG1284 481743016920 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 481743016921 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 481743016922 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 481743016923 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 481743016924 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 481743016925 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 481743016926 putative active site [active] 481743016927 catalytic site [active] 481743016928 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 481743016929 putative active site [active] 481743016930 catalytic site [active] 481743016931 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 481743016932 Peptidase family M23; Region: Peptidase_M23; pfam01551 481743016933 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 481743016934 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 481743016935 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 481743016936 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743016937 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 481743016938 Walker A/P-loop; other site 481743016939 ATP binding site [chemical binding]; other site 481743016940 Q-loop/lid; other site 481743016941 ABC transporter signature motif; other site 481743016942 Walker B; other site 481743016943 D-loop; other site 481743016944 H-loop/switch region; other site 481743016945 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 481743016946 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 481743016947 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 481743016948 Predicted integral membrane protein [Function unknown]; Region: COG5652 481743016949 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 481743016950 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 481743016951 active site 481743016952 Cupin domain; Region: Cupin_2; cl17218 481743016953 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 481743016954 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 481743016955 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 481743016956 putative metal binding site; other site 481743016957 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 481743016958 metal-binding site 481743016959 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 481743016960 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 481743016961 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 481743016962 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 481743016963 NADP-binding site; other site 481743016964 homotetramer interface [polypeptide binding]; other site 481743016965 substrate binding site [chemical binding]; other site 481743016966 homodimer interface [polypeptide binding]; other site 481743016967 active site 481743016968 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 481743016969 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 481743016970 NADP binding site [chemical binding]; other site 481743016971 active site 481743016972 putative substrate binding site [chemical binding]; other site 481743016973 Bacterial sugar transferase; Region: Bac_transf; pfam02397 481743016974 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 481743016975 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 481743016976 active site 481743016977 tetramer interface; other site 481743016978 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 481743016979 Chain length determinant protein; Region: Wzz; cl15801 481743016980 Domain of unknown function (DUF1854); Region: DUF1854; pfam08909 481743016981 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743016982 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743016983 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 481743016984 Walker A/P-loop; other site 481743016985 ATP binding site [chemical binding]; other site 481743016986 Q-loop/lid; other site 481743016987 ABC transporter signature motif; other site 481743016988 Walker B; other site 481743016989 D-loop; other site 481743016990 H-loop/switch region; other site 481743016991 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 481743016992 Catalytic site [active] 481743016993 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 481743016994 SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249 481743016995 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 481743016996 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 481743016997 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481743016998 non-specific DNA binding site [nucleotide binding]; other site 481743016999 salt bridge; other site 481743017000 sequence-specific DNA binding site [nucleotide binding]; other site 481743017001 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 481743017002 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 481743017003 active site 481743017004 dimer interface [polypeptide binding]; other site 481743017005 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 481743017006 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 481743017007 active site 481743017008 FMN binding site [chemical binding]; other site 481743017009 substrate binding site [chemical binding]; other site 481743017010 3Fe-4S cluster binding site [ion binding]; other site 481743017011 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 481743017012 domain interface; other site 481743017013 Predicted membrane protein [Function unknown]; Region: COG1511 481743017014 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 481743017015 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 481743017016 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 481743017017 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743017018 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743017019 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 481743017020 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 481743017021 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 481743017022 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 481743017023 metal-dependent hydrolase; Provisional; Region: PRK00685 481743017024 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 481743017025 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 481743017026 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 481743017027 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 481743017028 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 481743017029 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 481743017030 NAD binding site [chemical binding]; other site 481743017031 ligand binding site [chemical binding]; other site 481743017032 catalytic site [active] 481743017033 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 481743017034 DNA binding site [nucleotide binding] 481743017035 active site 481743017036 THUMP domain, predicted to bind RNA; Region: THUMP; cl12076 481743017037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743017038 S-adenosylmethionine binding site [chemical binding]; other site 481743017039 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 481743017040 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 481743017041 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 481743017042 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 481743017043 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 481743017044 Zn2+ binding site [ion binding]; other site 481743017045 Mg2+ binding site [ion binding]; other site 481743017046 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 481743017047 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 481743017048 sugar binding site [chemical binding]; other site 481743017049 Alginate lyase; Region: Alginate_lyase2; pfam08787 481743017050 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 481743017051 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 481743017052 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 481743017053 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 481743017054 Interdomain contacts; other site 481743017055 Cytokine receptor motif; other site 481743017056 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 481743017057 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 481743017058 sugar binding site [chemical binding]; other site 481743017059 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 481743017060 Right handed beta helix region; Region: Beta_helix; pfam13229 481743017061 Right handed beta helix region; Region: Beta_helix; pfam13229 481743017062 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 481743017063 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 481743017064 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 481743017065 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 481743017066 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 481743017067 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 481743017068 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 481743017069 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 481743017070 Phage-related protein [Function unknown]; Region: COG5412 481743017071 Phage XkdN-like protein; Region: XkdN; pfam08890 481743017072 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 481743017073 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 481743017074 Kelch motif; Region: Kelch_1; pfam01344 481743017075 Galactose oxidase, central domain; Region: Kelch_3; cl02701 481743017076 Kelch motif; Region: Kelch_1; pfam01344 481743017077 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 481743017078 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 481743017079 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 481743017080 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 481743017081 Phage XkdN-like protein; Region: XkdN; pfam08890 481743017082 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 481743017083 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 481743017084 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 481743017085 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 481743017086 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481743017087 non-specific DNA binding site [nucleotide binding]; other site 481743017088 salt bridge; other site 481743017089 sequence-specific DNA binding site [nucleotide binding]; other site 481743017090 Domain of unknown function (DUF955); Region: DUF955; cl01076 481743017091 RRNA methyltransferase AviRa; Region: AviRa; pfam11599 481743017092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 481743017093 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743017094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743017095 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743017096 LysE type translocator; Region: LysE; cl00565 481743017097 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 481743017098 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743017099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743017100 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 481743017101 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 481743017102 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 481743017103 Walker A/P-loop; other site 481743017104 ATP binding site [chemical binding]; other site 481743017105 Q-loop/lid; other site 481743017106 ABC transporter signature motif; other site 481743017107 Walker B; other site 481743017108 D-loop; other site 481743017109 H-loop/switch region; other site 481743017110 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 481743017111 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 481743017112 Walker A/P-loop; other site 481743017113 ATP binding site [chemical binding]; other site 481743017114 Q-loop/lid; other site 481743017115 ABC transporter signature motif; other site 481743017116 Walker B; other site 481743017117 D-loop; other site 481743017118 H-loop/switch region; other site 481743017119 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 481743017120 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 481743017121 short chain dehydrogenase; Provisional; Region: PRK06914 481743017122 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 481743017123 NADP binding site [chemical binding]; other site 481743017124 active site 481743017125 steroid binding site; other site 481743017126 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743017127 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743017128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743017129 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 481743017130 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743017131 DNA-binding site [nucleotide binding]; DNA binding site 481743017132 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743017133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743017134 homodimer interface [polypeptide binding]; other site 481743017135 catalytic residue [active] 481743017136 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 481743017137 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743017138 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 481743017139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743017140 homodimer interface [polypeptide binding]; other site 481743017141 catalytic residue [active] 481743017142 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 481743017143 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 481743017144 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481743017145 Walker A/P-loop; other site 481743017146 ATP binding site [chemical binding]; other site 481743017147 Q-loop/lid; other site 481743017148 ABC transporter signature motif; other site 481743017149 Walker B; other site 481743017150 D-loop; other site 481743017151 H-loop/switch region; other site 481743017152 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 481743017153 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 481743017154 ATP binding site [chemical binding]; other site 481743017155 putative Mg++ binding site [ion binding]; other site 481743017156 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481743017157 nucleotide binding region [chemical binding]; other site 481743017158 ATP-binding site [chemical binding]; other site 481743017159 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743017160 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743017161 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 481743017162 dimerization interface [polypeptide binding]; other site 481743017163 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 481743017164 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 481743017165 GDP-binding site [chemical binding]; other site 481743017166 ACT binding site; other site 481743017167 IMP binding site; other site 481743017168 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 481743017169 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 481743017170 Predicted transcriptional regulator [Transcription]; Region: COG2378 481743017171 HTH domain; Region: HTH_11; pfam08279 481743017172 WYL domain; Region: WYL; pfam13280 481743017173 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 481743017174 active site 481743017175 NTP binding site [chemical binding]; other site 481743017176 metal binding triad [ion binding]; metal-binding site 481743017177 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 481743017178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743017179 NAD(P) binding site [chemical binding]; other site 481743017180 active site 481743017181 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 481743017182 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 481743017183 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743017184 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743017185 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 481743017186 dimerization interface [polypeptide binding]; other site 481743017187 histidinol-phosphatase; Provisional; Region: PRK07328 481743017188 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 481743017189 active site 481743017190 dimer interface [polypeptide binding]; other site 481743017191 phosphodiesterase YaeI; Provisional; Region: PRK11340 481743017192 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 481743017193 putative active site [active] 481743017194 putative metal binding site [ion binding]; other site 481743017195 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 481743017196 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 481743017197 NAD(P) binding site [chemical binding]; other site 481743017198 catalytic residues [active] 481743017199 Ion channel; Region: Ion_trans_2; pfam07885 481743017200 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 481743017201 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 481743017202 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 481743017203 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 481743017204 L-aspartate oxidase; Provisional; Region: PRK06175 481743017205 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 481743017206 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 481743017207 putative Iron-sulfur protein interface [polypeptide binding]; other site 481743017208 proximal heme binding site [chemical binding]; other site 481743017209 distal heme binding site [chemical binding]; other site 481743017210 putative dimer interface [polypeptide binding]; other site 481743017211 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743017212 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743017213 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 481743017214 dimerization interface [polypeptide binding]; other site 481743017215 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 481743017216 TrkA-N domain; Region: TrkA_N; pfam02254 481743017217 TrkA-C domain; Region: TrkA_C; pfam02080 481743017218 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 481743017219 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 481743017220 CAAX protease self-immunity; Region: Abi; pfam02517 481743017221 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671 481743017222 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 481743017223 GIY-YIG motif/motif A; other site 481743017224 active site 481743017225 catalytic site [active] 481743017226 putative DNA binding site [nucleotide binding]; other site 481743017227 metal binding site [ion binding]; metal-binding site 481743017228 UvrB/uvrC motif; Region: UVR; pfam02151 481743017229 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 481743017230 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 481743017231 DNA binding site [nucleotide binding] 481743017232 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 481743017233 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 481743017234 catalytic residues [active] 481743017235 primosomal protein DnaI; Reviewed; Region: PRK08939 481743017236 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 481743017237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743017238 Walker A motif; other site 481743017239 ATP binding site [chemical binding]; other site 481743017240 Walker B motif; other site 481743017241 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 481743017242 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 481743017243 Putative membrane protein; Region: YuiB; pfam14068 481743017244 putative heme peroxidase; Provisional; Region: PRK12276 481743017245 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 481743017246 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481743017247 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 481743017248 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 481743017249 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481743017250 Sporulation inhibitor A; Region: Sda; pfam08970 481743017251 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 481743017252 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 481743017253 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 481743017254 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743017255 FeS/SAM binding site; other site 481743017256 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 481743017257 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481743017258 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 481743017259 NifU-like domain; Region: NifU; cl00484 481743017260 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 481743017261 classical (c) SDRs; Region: SDR_c; cd05233 481743017262 NAD(P) binding site [chemical binding]; other site 481743017263 active site 481743017264 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 481743017265 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 481743017266 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743017267 dimer interface [polypeptide binding]; other site 481743017268 conserved gate region; other site 481743017269 ABC-ATPase subunit interface; other site 481743017270 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 481743017271 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 481743017272 Walker A/P-loop; other site 481743017273 ATP binding site [chemical binding]; other site 481743017274 Q-loop/lid; other site 481743017275 ABC transporter signature motif; other site 481743017276 Walker B; other site 481743017277 D-loop; other site 481743017278 H-loop/switch region; other site 481743017279 NIL domain; Region: NIL; pfam09383 481743017280 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 481743017281 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 481743017282 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 481743017283 catalytic residues [active] 481743017284 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 481743017285 stage V sporulation protein B; Region: spore_V_B; TIGR02900 481743017286 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 481743017287 Protein of unknown function (DUF456); Region: DUF456; pfam04306 481743017288 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 481743017289 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743017290 active site 481743017291 motif I; other site 481743017292 motif II; other site 481743017293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743017294 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 481743017295 putative hydrophobic ligand binding site [chemical binding]; other site 481743017296 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 481743017297 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 481743017298 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 481743017299 Colicin V production protein; Region: Colicin_V; pfam02674 481743017300 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 481743017301 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 481743017302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743017303 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743017304 putative substrate translocation pore; other site 481743017305 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 481743017306 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 481743017307 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 481743017308 Cu(I) binding site [ion binding]; other site 481743017309 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 481743017310 UbiA prenyltransferase family; Region: UbiA; pfam01040 481743017311 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 481743017312 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 481743017313 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 481743017314 active site 481743017315 HIGH motif; other site 481743017316 dimer interface [polypeptide binding]; other site 481743017317 KMSKS motif; other site 481743017318 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 481743017319 active site 481743017320 catalytic residues [active] 481743017321 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 481743017322 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 481743017323 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 481743017324 active site 481743017325 Zn binding site [ion binding]; other site 481743017326 YycC-like protein; Region: YycC; pfam14174 481743017327 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 481743017328 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743017329 TPR motif; other site 481743017330 binding surface 481743017331 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 481743017332 apolar tunnel; other site 481743017333 heme binding site [chemical binding]; other site 481743017334 dimerization interface [polypeptide binding]; other site 481743017335 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 481743017336 Nucleoside recognition; Region: Gate; pfam07670 481743017337 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 481743017338 ATP-NAD kinase; Region: NAD_kinase; pfam01513 481743017339 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 481743017340 lipoyl synthase; Provisional; Region: PRK05481 481743017341 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743017342 FeS/SAM binding site; other site 481743017343 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 481743017344 Peptidase family M23; Region: Peptidase_M23; pfam01551 481743017345 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 481743017346 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743017347 putative DNA binding site [nucleotide binding]; other site 481743017348 dimerization interface [polypeptide binding]; other site 481743017349 putative Zn2+ binding site [ion binding]; other site 481743017350 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 481743017351 putative hydrophobic ligand binding site [chemical binding]; other site 481743017352 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 481743017353 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 481743017354 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 481743017355 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 481743017356 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 481743017357 TrkA-N domain; Region: TrkA_N; pfam02254 481743017358 TrkA-C domain; Region: TrkA_C; pfam02080 481743017359 Small, acid-soluble spore protein I; Region: SSPI; pfam14098 481743017360 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 481743017361 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 481743017362 G1 box; other site 481743017363 putative GEF interaction site [polypeptide binding]; other site 481743017364 GTP/Mg2+ binding site [chemical binding]; other site 481743017365 Switch I region; other site 481743017366 G2 box; other site 481743017367 G3 box; other site 481743017368 Switch II region; other site 481743017369 G4 box; other site 481743017370 G5 box; other site 481743017371 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 481743017372 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 481743017373 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 481743017374 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 481743017375 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 481743017376 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743017377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743017378 active site 481743017379 phosphorylation site [posttranslational modification] 481743017380 intermolecular recognition site; other site 481743017381 dimerization interface [polypeptide binding]; other site 481743017382 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743017383 DNA binding residues [nucleotide binding] 481743017384 dimerization interface [polypeptide binding]; other site 481743017385 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 481743017386 Histidine kinase; Region: HisKA_3; pfam07730 481743017387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743017388 ATP binding site [chemical binding]; other site 481743017389 Mg2+ binding site [ion binding]; other site 481743017390 G-X-G motif; other site 481743017391 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 481743017392 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 481743017393 PspC domain; Region: PspC; pfam04024 481743017394 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 481743017395 hypothetical protein; Provisional; Region: PRK02935 481743017396 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743017397 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 481743017398 active site 481743017399 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 481743017400 metal binding site 2 [ion binding]; metal-binding site 481743017401 putative DNA binding helix; other site 481743017402 metal binding site 1 [ion binding]; metal-binding site 481743017403 dimer interface [polypeptide binding]; other site 481743017404 structural Zn2+ binding site [ion binding]; other site 481743017405 Uncharacterized conserved protein [Function unknown]; Region: COG3595 481743017406 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 481743017407 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 481743017408 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 481743017409 MgtC family; Region: MgtC; pfam02308 481743017410 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 481743017411 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743017412 Coenzyme A binding pocket [chemical binding]; other site 481743017413 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 481743017414 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 481743017415 GatB domain; Region: GatB_Yqey; smart00845 481743017416 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 481743017417 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 481743017418 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 481743017419 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743017420 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481743017421 Walker A/P-loop; other site 481743017422 ATP binding site [chemical binding]; other site 481743017423 Q-loop/lid; other site 481743017424 ABC transporter signature motif; other site 481743017425 Walker B; other site 481743017426 D-loop; other site 481743017427 H-loop/switch region; other site 481743017428 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 481743017429 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 481743017430 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743017431 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743017432 DNA binding residues [nucleotide binding] 481743017433 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 481743017434 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 481743017435 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 481743017436 Methyltransferase domain; Region: Methyltransf_31; pfam13847 481743017437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743017438 S-adenosylmethionine binding site [chemical binding]; other site 481743017439 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 481743017440 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 481743017441 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 481743017442 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 481743017443 Pirin-related protein [General function prediction only]; Region: COG1741 481743017444 Pirin; Region: Pirin; pfam02678 481743017445 L-asparaginase II; Region: Asparaginase_II; pfam06089 481743017446 Predicted membrane protein [Function unknown]; Region: COG2261 481743017447 YtxH-like protein; Region: YtxH; pfam12732 481743017448 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 481743017449 Cl binding site [ion binding]; other site 481743017450 oligomer interface [polypeptide binding]; other site 481743017451 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 481743017452 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 481743017453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743017454 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 481743017455 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743017456 DNA binding residues [nucleotide binding] 481743017457 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 481743017458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743017459 ATP binding site [chemical binding]; other site 481743017460 Mg2+ binding site [ion binding]; other site 481743017461 G-X-G motif; other site 481743017462 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 481743017463 anti sigma factor interaction site; other site 481743017464 regulatory phosphorylation site [posttranslational modification]; other site 481743017465 Response regulator receiver domain; Region: Response_reg; pfam00072 481743017466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743017467 active site 481743017468 phosphorylation site [posttranslational modification] 481743017469 intermolecular recognition site; other site 481743017470 dimerization interface [polypeptide binding]; other site 481743017471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743017472 dimer interface [polypeptide binding]; other site 481743017473 phosphorylation site [posttranslational modification] 481743017474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743017475 ATP binding site [chemical binding]; other site 481743017476 Mg2+ binding site [ion binding]; other site 481743017477 G-X-G motif; other site 481743017478 Response regulator receiver domain; Region: Response_reg; pfam00072 481743017479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743017480 active site 481743017481 phosphorylation site [posttranslational modification] 481743017482 intermolecular recognition site; other site 481743017483 dimerization interface [polypeptide binding]; other site 481743017484 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 481743017485 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 481743017486 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 481743017487 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 481743017488 HAMP domain; Region: HAMP; pfam00672 481743017489 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 481743017490 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 481743017491 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743017492 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743017493 dimer interface [polypeptide binding]; other site 481743017494 phosphorylation site [posttranslational modification] 481743017495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743017496 ATP binding site [chemical binding]; other site 481743017497 Mg2+ binding site [ion binding]; other site 481743017498 G-X-G motif; other site 481743017499 Response regulator receiver domain; Region: Response_reg; pfam00072 481743017500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743017501 active site 481743017502 phosphorylation site [posttranslational modification] 481743017503 intermolecular recognition site; other site 481743017504 dimerization interface [polypeptide binding]; other site 481743017505 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 481743017506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743017507 active site 481743017508 phosphorylation site [posttranslational modification] 481743017509 intermolecular recognition site; other site 481743017510 dimerization interface [polypeptide binding]; other site 481743017511 Response regulator receiver domain; Region: Response_reg; pfam00072 481743017512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743017513 active site 481743017514 phosphorylation site [posttranslational modification] 481743017515 intermolecular recognition site; other site 481743017516 dimerization interface [polypeptide binding]; other site 481743017517 Response regulator receiver domain; Region: Response_reg; pfam00072 481743017518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743017519 active site 481743017520 phosphorylation site [posttranslational modification] 481743017521 intermolecular recognition site; other site 481743017522 dimerization interface [polypeptide binding]; other site 481743017523 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 481743017524 Heat induced stress protein YflT; Region: YflT; pfam11181 481743017525 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 481743017526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743017527 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 481743017528 putative substrate translocation pore; other site 481743017529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743017530 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481743017531 MarR family; Region: MarR; pfam01047 481743017532 MarR family; Region: MarR_2; cl17246 481743017533 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 481743017534 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 481743017535 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 481743017536 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481743017537 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481743017538 ABC transporter; Region: ABC_tran_2; pfam12848 481743017539 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481743017540 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 481743017541 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 481743017542 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 481743017543 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 481743017544 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 481743017545 Virulence factor; Region: Virulence_fact; pfam13769 481743017546 HEAT repeats; Region: HEAT_2; pfam13646 481743017547 HEAT repeats; Region: HEAT_2; pfam13646 481743017548 HEAT repeats; Region: HEAT_2; pfam13646 481743017549 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 481743017550 lysine transporter; Provisional; Region: PRK10836 481743017551 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 481743017552 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 481743017553 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 481743017554 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 481743017555 active site 481743017556 intersubunit interface [polypeptide binding]; other site 481743017557 catalytic residue [active] 481743017558 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 481743017559 N- and C-terminal domain interface [polypeptide binding]; other site 481743017560 D-xylulose kinase; Region: XylB; TIGR01312 481743017561 active site 481743017562 MgATP binding site [chemical binding]; other site 481743017563 catalytic site [active] 481743017564 metal binding site [ion binding]; metal-binding site 481743017565 xylulose binding site [chemical binding]; other site 481743017566 homodimer interface [polypeptide binding]; other site 481743017567 xylose isomerase; Provisional; Region: PRK05474 481743017568 xylose isomerase; Region: xylose_isom_A; TIGR02630 481743017569 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 481743017570 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 481743017571 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 481743017572 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 481743017573 catalytic residues [active] 481743017574 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 481743017575 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 481743017576 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481743017577 Leucine rich repeat; Region: LRR_8; pfam13855 481743017578 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 481743017579 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 481743017580 Soluble P-type ATPase [General function prediction only]; Region: COG4087 481743017581 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 481743017582 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248 481743017583 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 481743017584 homodimer interface [polypeptide binding]; other site 481743017585 substrate-cofactor binding pocket; other site 481743017586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743017587 catalytic residue [active] 481743017588 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 481743017589 classical (c) SDRs; Region: SDR_c; cd05233 481743017590 NAD(P) binding site [chemical binding]; other site 481743017591 active site 481743017592 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 481743017593 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 481743017594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743017595 Walker A/P-loop; other site 481743017596 ATP binding site [chemical binding]; other site 481743017597 Q-loop/lid; other site 481743017598 ABC transporter signature motif; other site 481743017599 Walker B; other site 481743017600 D-loop; other site 481743017601 H-loop/switch region; other site 481743017602 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 481743017603 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743017604 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743017605 DNA binding residues [nucleotide binding] 481743017606 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 481743017607 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 481743017608 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743017609 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 481743017610 Walker A/P-loop; other site 481743017611 ATP binding site [chemical binding]; other site 481743017612 Q-loop/lid; other site 481743017613 ABC transporter signature motif; other site 481743017614 Walker B; other site 481743017615 D-loop; other site 481743017616 H-loop/switch region; other site 481743017617 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481743017618 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481743017619 active site 481743017620 catalytic tetrad [active] 481743017621 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 481743017622 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 481743017623 Melibiase; Region: Melibiase; pfam02065 481743017624 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 481743017625 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 481743017626 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 481743017627 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 481743017628 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743017629 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743017630 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743017631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743017632 dimer interface [polypeptide binding]; other site 481743017633 conserved gate region; other site 481743017634 putative PBP binding loops; other site 481743017635 ABC-ATPase subunit interface; other site 481743017636 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743017637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743017638 dimer interface [polypeptide binding]; other site 481743017639 conserved gate region; other site 481743017640 putative PBP binding loops; other site 481743017641 ABC-ATPase subunit interface; other site 481743017642 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743017643 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743017644 dimerization interface [polypeptide binding]; other site 481743017645 Histidine kinase; Region: His_kinase; pfam06580 481743017646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 481743017647 ATP binding site [chemical binding]; other site 481743017648 Mg2+ binding site [ion binding]; other site 481743017649 G-X-G motif; other site 481743017650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743017651 Response regulator receiver domain; Region: Response_reg; pfam00072 481743017652 active site 481743017653 phosphorylation site [posttranslational modification] 481743017654 intermolecular recognition site; other site 481743017655 dimerization interface [polypeptide binding]; other site 481743017656 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743017657 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743017658 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743017659 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 481743017660 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 481743017661 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 481743017662 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 481743017663 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743017664 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743017665 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743017666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743017667 dimer interface [polypeptide binding]; other site 481743017668 conserved gate region; other site 481743017669 ABC-ATPase subunit interface; other site 481743017670 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743017671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743017672 dimer interface [polypeptide binding]; other site 481743017673 conserved gate region; other site 481743017674 ABC-ATPase subunit interface; other site 481743017675 Response regulator receiver domain; Region: Response_reg; pfam00072 481743017676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743017677 active site 481743017678 phosphorylation site [posttranslational modification] 481743017679 intermolecular recognition site; other site 481743017680 dimerization interface [polypeptide binding]; other site 481743017681 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743017682 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743017683 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743017684 dimerization interface [polypeptide binding]; other site 481743017685 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743017686 Histidine kinase; Region: His_kinase; pfam06580 481743017687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743017688 ATP binding site [chemical binding]; other site 481743017689 Mg2+ binding site [ion binding]; other site 481743017690 G-X-G motif; other site 481743017691 putative alpha-glucosidase; Provisional; Region: PRK10658 481743017692 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 481743017693 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 481743017694 active site 481743017695 homotrimer interface [polypeptide binding]; other site 481743017696 catalytic site [active] 481743017697 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 481743017698 Cupin domain; Region: Cupin_2; pfam07883 481743017699 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743017700 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743017701 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743017702 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 481743017703 aromatic chitin/cellulose binding site residues [chemical binding]; other site 481743017704 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 481743017705 active site 481743017706 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 481743017707 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 481743017708 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 481743017709 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 481743017710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743017711 benzoate transport; Region: 2A0115; TIGR00895 481743017712 putative substrate translocation pore; other site 481743017713 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 481743017714 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481743017715 putative active site [active] 481743017716 heme pocket [chemical binding]; other site 481743017717 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743017718 dimer interface [polypeptide binding]; other site 481743017719 phosphorylation site [posttranslational modification] 481743017720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743017721 ATP binding site [chemical binding]; other site 481743017722 Mg2+ binding site [ion binding]; other site 481743017723 G-X-G motif; other site 481743017724 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 481743017725 Predicted membrane protein [Function unknown]; Region: COG1238 481743017726 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 481743017727 dimer interface [polypeptide binding]; other site 481743017728 substrate binding site [chemical binding]; other site 481743017729 ATP binding site [chemical binding]; other site 481743017730 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 481743017731 active site 481743017732 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 481743017733 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 481743017734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743017735 S-adenosylmethionine binding site [chemical binding]; other site 481743017736 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 481743017737 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 481743017738 Cysteine-rich domain; Region: CCG; pfam02754 481743017739 Cysteine-rich domain; Region: CCG; pfam02754 481743017740 FAD binding domain; Region: FAD_binding_4; pfam01565 481743017741 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 481743017742 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 481743017743 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 481743017744 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 481743017745 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 481743017746 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 481743017747 Walker A/P-loop; other site 481743017748 ATP binding site [chemical binding]; other site 481743017749 Q-loop/lid; other site 481743017750 ABC transporter signature motif; other site 481743017751 Walker B; other site 481743017752 D-loop; other site 481743017753 H-loop/switch region; other site 481743017754 TOBE domain; Region: TOBE_2; pfam08402 481743017755 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743017756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743017757 dimer interface [polypeptide binding]; other site 481743017758 conserved gate region; other site 481743017759 putative PBP binding loops; other site 481743017760 ABC-ATPase subunit interface; other site 481743017761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743017762 dimer interface [polypeptide binding]; other site 481743017763 conserved gate region; other site 481743017764 putative PBP binding loops; other site 481743017765 ABC-ATPase subunit interface; other site 481743017766 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743017767 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743017768 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 481743017769 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 481743017770 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 481743017771 putative active site [active] 481743017772 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 481743017773 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 481743017774 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 481743017775 putative active site [active] 481743017776 short chain dehydrogenase; Provisional; Region: PRK06197 481743017777 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 481743017778 putative NAD(P) binding site [chemical binding]; other site 481743017779 active site 481743017780 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 481743017781 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 481743017782 Mg++ binding site [ion binding]; other site 481743017783 putative catalytic motif [active] 481743017784 substrate binding site [chemical binding]; other site 481743017785 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 481743017786 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 481743017787 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 481743017788 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 481743017789 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 481743017790 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 481743017791 phosphopentomutase; Provisional; Region: PRK05362 481743017792 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 481743017793 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 481743017794 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 481743017795 Nucleoside recognition; Region: Gate; pfam07670 481743017796 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 481743017797 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 481743017798 intersubunit interface [polypeptide binding]; other site 481743017799 active site 481743017800 catalytic residue [active] 481743017801 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 481743017802 Helix-turn-helix domain; Region: HTH_36; pfam13730 481743017803 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 481743017804 MMPL family; Region: MMPL; pfam03176 481743017805 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 481743017806 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743017807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743017808 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 481743017809 conserved cys residue [active] 481743017810 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743017811 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743017812 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743017813 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 481743017814 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 481743017815 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 481743017816 RNA/DNA hybrid binding site [nucleotide binding]; other site 481743017817 active site 481743017818 Predicted transcriptional regulator [Transcription]; Region: COG2378 481743017819 HTH domain; Region: HTH_11; pfam08279 481743017820 WYL domain; Region: WYL; pfam13280 481743017821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 481743017822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 481743017823 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 481743017824 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 481743017825 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 481743017826 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 481743017827 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 481743017828 inhibitor-cofactor binding pocket; inhibition site 481743017829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743017830 catalytic residue [active] 481743017831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743017832 Coenzyme A binding pocket [chemical binding]; other site 481743017833 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 481743017834 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 481743017835 Walker A/P-loop; other site 481743017836 ATP binding site [chemical binding]; other site 481743017837 Q-loop/lid; other site 481743017838 ABC transporter signature motif; other site 481743017839 Walker B; other site 481743017840 D-loop; other site 481743017841 H-loop/switch region; other site 481743017842 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 481743017843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743017844 dimer interface [polypeptide binding]; other site 481743017845 conserved gate region; other site 481743017846 putative PBP binding loops; other site 481743017847 ABC-ATPase subunit interface; other site 481743017848 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 481743017849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743017850 dimer interface [polypeptide binding]; other site 481743017851 conserved gate region; other site 481743017852 putative PBP binding loops; other site 481743017853 ABC-ATPase subunit interface; other site 481743017854 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 481743017855 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481743017856 substrate binding pocket [chemical binding]; other site 481743017857 membrane-bound complex binding site; other site 481743017858 hinge residues; other site 481743017859 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 481743017860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743017861 NAD(P) binding site [chemical binding]; other site 481743017862 active site 481743017863 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 481743017864 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 481743017865 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743017866 Zn binding site [ion binding]; other site 481743017867 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 481743017868 Zn binding site [ion binding]; other site 481743017869 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 481743017870 Domain of unknown function DUF20; Region: UPF0118; pfam01594 481743017871 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 481743017872 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 481743017873 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 481743017874 putative active site [active] 481743017875 catalytic site [active] 481743017876 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 481743017877 putative active site [active] 481743017878 catalytic site [active] 481743017879 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 481743017880 dimer interface [polypeptide binding]; other site 481743017881 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743017882 MarR family; Region: MarR_2; pfam12802 481743017883 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 481743017884 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743017885 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 481743017886 Interdomain contacts; other site 481743017887 Cytokine receptor motif; other site 481743017888 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 481743017889 Interdomain contacts; other site 481743017890 Cytokine receptor motif; other site 481743017891 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 481743017892 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 481743017893 Interdomain contacts; other site 481743017894 Cytokine receptor motif; other site 481743017895 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 481743017896 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 481743017897 active site 481743017898 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 481743017899 Interdomain contacts; other site 481743017900 S-layer homology domain; Region: SLH; pfam00395 481743017901 S-layer homology domain; Region: SLH; pfam00395 481743017902 SnoaL-like domain; Region: SnoaL_3; pfam13474 481743017903 SnoaL-like domain; Region: SnoaL_2; pfam12680 481743017904 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 481743017905 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 481743017906 DNA binding residues [nucleotide binding] 481743017907 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 481743017908 dimer interface [polypeptide binding]; other site 481743017909 FMN binding site [chemical binding]; other site 481743017910 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 481743017911 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 481743017912 FMN binding site [chemical binding]; other site 481743017913 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 481743017914 Predicted transcriptional regulators [Transcription]; Region: COG1733 481743017915 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 481743017916 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 481743017917 metal ion-dependent adhesion site (MIDAS); other site 481743017918 Tubulin like; Region: Tubulin_2; pfam13809 481743017919 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 481743017920 metal ion-dependent adhesion site (MIDAS); other site 481743017921 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 481743017922 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 481743017923 glutaminase active site [active] 481743017924 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 481743017925 dimer interface [polypeptide binding]; other site 481743017926 active site 481743017927 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 481743017928 dimer interface [polypeptide binding]; other site 481743017929 active site 481743017930 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 481743017931 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 481743017932 active site 481743017933 substrate binding site [chemical binding]; other site 481743017934 metal binding site [ion binding]; metal-binding site 481743017935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 481743017936 YbbR-like protein; Region: YbbR; pfam07949 481743017937 YbbR-like protein; Region: YbbR; pfam07949 481743017938 TIGR00159 family protein; Region: TIGR00159 481743017939 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 481743017940 Putative zinc-finger; Region: zf-HC2; pfam13490 481743017941 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 481743017942 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 481743017943 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 481743017944 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743017945 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743017946 DNA binding residues [nucleotide binding] 481743017947 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 481743017948 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 481743017949 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 481743017950 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 481743017951 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 481743017952 antiporter inner membrane protein; Provisional; Region: PRK11670 481743017953 Domain of unknown function DUF59; Region: DUF59; pfam01883 481743017954 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 481743017955 Walker A motif; other site 481743017956 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 481743017957 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 481743017958 active site 481743017959 metal binding site [ion binding]; metal-binding site 481743017960 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 481743017961 ATP-sulfurylase; Region: ATPS; cd00517 481743017962 active site 481743017963 HXXH motif; other site 481743017964 flexible loop; other site 481743017965 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 481743017966 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 481743017967 Active Sites [active] 481743017968 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743017969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743017970 putative substrate translocation pore; other site 481743017971 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481743017972 MarR family; Region: MarR; pfam01047 481743017973 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 481743017974 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 481743017975 23S rRNA interface [nucleotide binding]; other site 481743017976 L3 interface [polypeptide binding]; other site 481743017977 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 481743017978 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 481743017979 dimerization interface 3.5A [polypeptide binding]; other site 481743017980 active site 481743017981 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 481743017982 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 481743017983 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 481743017984 alphaNTD - beta interaction site [polypeptide binding]; other site 481743017985 alphaNTD homodimer interface [polypeptide binding]; other site 481743017986 alphaNTD - beta' interaction site [polypeptide binding]; other site 481743017987 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 481743017988 30S ribosomal protein S11; Validated; Region: PRK05309 481743017989 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 481743017990 30S ribosomal protein S13; Region: bact_S13; TIGR03631 481743017991 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 481743017992 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 481743017993 rRNA binding site [nucleotide binding]; other site 481743017994 predicted 30S ribosome binding site; other site 481743017995 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 481743017996 RNA binding site [nucleotide binding]; other site 481743017997 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 481743017998 active site 481743017999 adenylate kinase; Reviewed; Region: adk; PRK00279 481743018000 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 481743018001 AMP-binding site [chemical binding]; other site 481743018002 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 481743018003 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 481743018004 SecY translocase; Region: SecY; pfam00344 481743018005 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 481743018006 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 481743018007 23S rRNA binding site [nucleotide binding]; other site 481743018008 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 481743018009 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 481743018010 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 481743018011 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 481743018012 5S rRNA interface [nucleotide binding]; other site 481743018013 L27 interface [polypeptide binding]; other site 481743018014 23S rRNA interface [nucleotide binding]; other site 481743018015 L5 interface [polypeptide binding]; other site 481743018016 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 481743018017 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 481743018018 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 481743018019 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 481743018020 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 481743018021 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 481743018022 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 481743018023 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 481743018024 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 481743018025 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 481743018026 RNA binding site [nucleotide binding]; other site 481743018027 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 481743018028 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 481743018029 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 481743018030 23S rRNA interface [nucleotide binding]; other site 481743018031 putative translocon interaction site; other site 481743018032 signal recognition particle (SRP54) interaction site; other site 481743018033 L23 interface [polypeptide binding]; other site 481743018034 trigger factor interaction site; other site 481743018035 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 481743018036 23S rRNA interface [nucleotide binding]; other site 481743018037 5S rRNA interface [nucleotide binding]; other site 481743018038 putative antibiotic binding site [chemical binding]; other site 481743018039 L25 interface [polypeptide binding]; other site 481743018040 L27 interface [polypeptide binding]; other site 481743018041 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 481743018042 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 481743018043 G-X-X-G motif; other site 481743018044 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 481743018045 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 481743018046 putative translocon binding site; other site 481743018047 protein-rRNA interface [nucleotide binding]; other site 481743018048 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 481743018049 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 481743018050 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 481743018051 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 481743018052 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 481743018053 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 481743018054 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 481743018055 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 481743018056 elongation factor Tu; Reviewed; Region: PRK00049 481743018057 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 481743018058 G1 box; other site 481743018059 GEF interaction site [polypeptide binding]; other site 481743018060 GTP/Mg2+ binding site [chemical binding]; other site 481743018061 Switch I region; other site 481743018062 G2 box; other site 481743018063 G3 box; other site 481743018064 Switch II region; other site 481743018065 G4 box; other site 481743018066 G5 box; other site 481743018067 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 481743018068 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 481743018069 Antibiotic Binding Site [chemical binding]; other site 481743018070 elongation factor G; Reviewed; Region: PRK00007 481743018071 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 481743018072 G1 box; other site 481743018073 putative GEF interaction site [polypeptide binding]; other site 481743018074 GTP/Mg2+ binding site [chemical binding]; other site 481743018075 Switch I region; other site 481743018076 G2 box; other site 481743018077 G3 box; other site 481743018078 Switch II region; other site 481743018079 G4 box; other site 481743018080 G5 box; other site 481743018081 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 481743018082 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 481743018083 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 481743018084 30S ribosomal protein S7; Validated; Region: PRK05302 481743018085 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 481743018086 S17 interaction site [polypeptide binding]; other site 481743018087 S8 interaction site; other site 481743018088 16S rRNA interaction site [nucleotide binding]; other site 481743018089 streptomycin interaction site [chemical binding]; other site 481743018090 23S rRNA interaction site [nucleotide binding]; other site 481743018091 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 481743018092 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 481743018093 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 481743018094 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 481743018095 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 481743018096 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 481743018097 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 481743018098 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 481743018099 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 481743018100 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 481743018101 G-loop; other site 481743018102 DNA binding site [nucleotide binding] 481743018103 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 481743018104 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 481743018105 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 481743018106 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 481743018107 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 481743018108 RPB10 interaction site [polypeptide binding]; other site 481743018109 RPB1 interaction site [polypeptide binding]; other site 481743018110 RPB11 interaction site [polypeptide binding]; other site 481743018111 RPB3 interaction site [polypeptide binding]; other site 481743018112 RPB12 interaction site [polypeptide binding]; other site 481743018113 Methyltransferase domain; Region: Methyltransf_31; pfam13847 481743018114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743018115 S-adenosylmethionine binding site [chemical binding]; other site 481743018116 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 481743018117 core dimer interface [polypeptide binding]; other site 481743018118 peripheral dimer interface [polypeptide binding]; other site 481743018119 L10 interface [polypeptide binding]; other site 481743018120 L11 interface [polypeptide binding]; other site 481743018121 putative EF-Tu interaction site [polypeptide binding]; other site 481743018122 putative EF-G interaction site [polypeptide binding]; other site 481743018123 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 481743018124 23S rRNA interface [nucleotide binding]; other site 481743018125 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 481743018126 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 481743018127 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 481743018128 23S rRNA interface [nucleotide binding]; other site 481743018129 L7/L12 interface [polypeptide binding]; other site 481743018130 putative thiostrepton binding site; other site 481743018131 L25 interface [polypeptide binding]; other site 481743018132 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 481743018133 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 481743018134 putative homodimer interface [polypeptide binding]; other site 481743018135 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 481743018136 heterodimer interface [polypeptide binding]; other site 481743018137 homodimer interface [polypeptide binding]; other site 481743018138 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 481743018139 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 481743018140 RNA polymerase factor sigma-70; Validated; Region: PRK08295 481743018141 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743018142 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 481743018143 YacP-like NYN domain; Region: NYN_YacP; pfam05991 481743018144 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 481743018145 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 481743018146 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 481743018147 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 481743018148 active site 481743018149 metal binding site [ion binding]; metal-binding site 481743018150 dimerization interface [polypeptide binding]; other site 481743018151 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 481743018152 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 481743018153 active site 481743018154 HIGH motif; other site 481743018155 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 481743018156 KMSKS motif; other site 481743018157 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 481743018158 tRNA binding surface [nucleotide binding]; other site 481743018159 anticodon binding site; other site 481743018160 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 481743018161 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 481743018162 trimer interface [polypeptide binding]; other site 481743018163 active site 481743018164 substrate binding site [chemical binding]; other site 481743018165 CoA binding site [chemical binding]; other site 481743018166 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 481743018167 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 481743018168 HIGH motif; other site 481743018169 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 481743018170 active site 481743018171 KMSKS motif; other site 481743018172 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 481743018173 homotrimer interaction site [polypeptide binding]; other site 481743018174 zinc binding site [ion binding]; other site 481743018175 CDP-binding sites; other site 481743018176 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 481743018177 substrate binding site; other site 481743018178 dimer interface; other site 481743018179 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 481743018180 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 481743018181 putative active site [active] 481743018182 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 481743018183 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 481743018184 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 481743018185 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 481743018186 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 481743018187 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 481743018188 DNA repair protein RadA; Provisional; Region: PRK11823 481743018189 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 481743018190 Walker A motif/ATP binding site; other site 481743018191 ATP binding site [chemical binding]; other site 481743018192 Walker B motif; other site 481743018193 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 481743018194 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 481743018195 Clp amino terminal domain; Region: Clp_N; pfam02861 481743018196 Clp amino terminal domain; Region: Clp_N; pfam02861 481743018197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743018198 Walker A motif; other site 481743018199 ATP binding site [chemical binding]; other site 481743018200 Walker B motif; other site 481743018201 arginine finger; other site 481743018202 UvrB/uvrC motif; Region: UVR; pfam02151 481743018203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481743018204 Walker A motif; other site 481743018205 ATP binding site [chemical binding]; other site 481743018206 Walker B motif; other site 481743018207 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 481743018208 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 481743018209 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 481743018210 ADP binding site [chemical binding]; other site 481743018211 phosphagen binding site; other site 481743018212 substrate specificity loop; other site 481743018213 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 481743018214 UvrB/uvrC motif; Region: UVR; pfam02151 481743018215 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 481743018216 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 481743018217 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743018218 DNA-binding site [nucleotide binding]; DNA binding site 481743018219 UTRA domain; Region: UTRA; pfam07702 481743018220 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 481743018221 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 481743018222 substrate binding site [chemical binding]; other site 481743018223 ATP binding site [chemical binding]; other site 481743018224 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 481743018225 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 481743018226 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 481743018227 catalytic residue [active] 481743018228 dihydroorotase; Provisional; Region: PRK09237 481743018229 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 481743018230 active site 481743018231 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 481743018232 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481743018233 Walker A/P-loop; other site 481743018234 ATP binding site [chemical binding]; other site 481743018235 Q-loop/lid; other site 481743018236 ABC transporter signature motif; other site 481743018237 Walker B; other site 481743018238 D-loop; other site 481743018239 H-loop/switch region; other site 481743018240 Predicted transcriptional regulators [Transcription]; Region: COG1725 481743018241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743018242 DNA-binding site [nucleotide binding]; DNA binding site 481743018243 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 481743018244 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 481743018245 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743018246 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 481743018247 Walker A/P-loop; other site 481743018248 ATP binding site [chemical binding]; other site 481743018249 Q-loop/lid; other site 481743018250 ABC transporter signature motif; other site 481743018251 Walker B; other site 481743018252 D-loop; other site 481743018253 H-loop/switch region; other site 481743018254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743018255 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743018256 putative substrate translocation pore; other site 481743018257 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 481743018258 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 481743018259 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 481743018260 putative active site [active] 481743018261 catalytic triad [active] 481743018262 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 481743018263 putative integrin binding motif; other site 481743018264 PA/protease domain interface [polypeptide binding]; other site 481743018265 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 481743018266 S-layer homology domain; Region: SLH; pfam00395 481743018267 S-layer homology domain; Region: SLH; pfam00395 481743018268 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 481743018269 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 481743018270 nucleotide binding pocket [chemical binding]; other site 481743018271 K-X-D-G motif; other site 481743018272 catalytic site [active] 481743018273 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 481743018274 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 481743018275 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 481743018276 Part of AAA domain; Region: AAA_19; pfam13245 481743018277 Family description; Region: UvrD_C_2; pfam13538 481743018278 PcrB family; Region: PcrB; pfam01884 481743018279 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 481743018280 substrate binding site [chemical binding]; other site 481743018281 putative active site [active] 481743018282 dimer interface [polypeptide binding]; other site 481743018283 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 481743018284 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar1; cd08583 481743018285 putative active site [active] 481743018286 catalytic site [active] 481743018287 Methyltransferase domain; Region: Methyltransf_31; pfam13847 481743018288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743018289 S-adenosylmethionine binding site [chemical binding]; other site 481743018290 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 481743018291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743018292 NAD(P) binding site [chemical binding]; other site 481743018293 active site 481743018294 Bacterial sugar transferase; Region: Bac_transf; pfam02397 481743018295 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 481743018296 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 481743018297 Probable Catalytic site; other site 481743018298 metal-binding site 481743018299 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 481743018300 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 481743018301 NADP binding site [chemical binding]; other site 481743018302 active site 481743018303 putative substrate binding site [chemical binding]; other site 481743018304 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 481743018305 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 481743018306 NAD binding site [chemical binding]; other site 481743018307 substrate binding site [chemical binding]; other site 481743018308 homodimer interface [polypeptide binding]; other site 481743018309 active site 481743018310 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 481743018311 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 481743018312 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 481743018313 substrate binding site; other site 481743018314 tetramer interface; other site 481743018315 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 481743018316 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 481743018317 Ligand binding site; other site 481743018318 Putative Catalytic site; other site 481743018319 DXD motif; other site 481743018320 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 481743018321 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 481743018322 inhibitor-cofactor binding pocket; inhibition site 481743018323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743018324 catalytic residue [active] 481743018325 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 481743018326 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 481743018327 putative trimer interface [polypeptide binding]; other site 481743018328 putative active site [active] 481743018329 putative substrate binding site [chemical binding]; other site 481743018330 putative CoA binding site [chemical binding]; other site 481743018331 WxcM-like, C-terminal; Region: FdtA; pfam05523 481743018332 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 481743018333 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 481743018334 Methyltransferase domain; Region: Methyltransf_23; pfam13489 481743018335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743018336 S-adenosylmethionine binding site [chemical binding]; other site 481743018337 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 481743018338 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 481743018339 active site 481743018340 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 481743018341 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 481743018342 Probable Catalytic site; other site 481743018343 metal-binding site 481743018344 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 481743018345 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 481743018346 Walker A/P-loop; other site 481743018347 ATP binding site [chemical binding]; other site 481743018348 Q-loop/lid; other site 481743018349 ABC transporter signature motif; other site 481743018350 Walker B; other site 481743018351 D-loop; other site 481743018352 H-loop/switch region; other site 481743018353 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 481743018354 putative carbohydrate binding site [chemical binding]; other site 481743018355 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 481743018356 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 481743018357 O-Antigen ligase; Region: Wzy_C; pfam04932 481743018358 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 481743018359 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 481743018360 active site 481743018361 tetramer interface; other site 481743018362 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 481743018363 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 481743018364 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 481743018365 Peptidase family U32; Region: Peptidase_U32; pfam01136 481743018366 Collagenase; Region: DUF3656; pfam12392 481743018367 Peptidase family U32; Region: Peptidase_U32; cl03113 481743018368 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 481743018369 drug efflux system protein MdtG; Provisional; Region: PRK09874 481743018370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743018371 putative substrate translocation pore; other site 481743018372 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 481743018373 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 481743018374 G1 box; other site 481743018375 putative GEF interaction site [polypeptide binding]; other site 481743018376 GTP/Mg2+ binding site [chemical binding]; other site 481743018377 Switch I region; other site 481743018378 G2 box; other site 481743018379 G3 box; other site 481743018380 Switch II region; other site 481743018381 G4 box; other site 481743018382 G5 box; other site 481743018383 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 481743018384 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 481743018385 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 481743018386 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743018387 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743018388 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 481743018389 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 481743018390 active site 481743018391 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 481743018392 protein binding site [polypeptide binding]; other site 481743018393 S-layer homology domain; Region: SLH; pfam00395 481743018394 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 481743018395 Interdomain contacts; other site 481743018396 Cytokine receptor motif; other site 481743018397 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 481743018398 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 481743018399 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 481743018400 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 481743018401 excinuclease ABC subunit B; Provisional; Region: PRK05298 481743018402 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481743018403 ATP binding site [chemical binding]; other site 481743018404 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481743018405 nucleotide binding region [chemical binding]; other site 481743018406 ATP-binding site [chemical binding]; other site 481743018407 Ultra-violet resistance protein B; Region: UvrB; pfam12344 481743018408 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 481743018409 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 481743018410 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 481743018411 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 481743018412 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 481743018413 ligand binding site [chemical binding]; other site 481743018414 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 481743018415 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 481743018416 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 481743018417 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 481743018418 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 481743018419 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743018420 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743018421 Walker A/P-loop; other site 481743018422 ATP binding site [chemical binding]; other site 481743018423 Q-loop/lid; other site 481743018424 ABC transporter signature motif; other site 481743018425 Walker B; other site 481743018426 D-loop; other site 481743018427 H-loop/switch region; other site 481743018428 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 481743018429 Histidine kinase; Region: HisKA_3; pfam07730 481743018430 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 481743018431 ATP binding site [chemical binding]; other site 481743018432 Mg2+ binding site [ion binding]; other site 481743018433 G-X-G motif; other site 481743018434 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743018435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743018436 active site 481743018437 phosphorylation site [posttranslational modification] 481743018438 intermolecular recognition site; other site 481743018439 dimerization interface [polypeptide binding]; other site 481743018440 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743018441 DNA binding residues [nucleotide binding] 481743018442 dimerization interface [polypeptide binding]; other site 481743018443 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 481743018444 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 481743018445 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 481743018446 C-terminal peptidase (prc); Region: prc; TIGR00225 481743018447 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 481743018448 protein binding site [polypeptide binding]; other site 481743018449 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 481743018450 Catalytic dyad [active] 481743018451 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 481743018452 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 481743018453 Peptidase family M23; Region: Peptidase_M23; pfam01551 481743018454 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 481743018455 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 481743018456 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 481743018457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743018458 Walker A/P-loop; other site 481743018459 ATP binding site [chemical binding]; other site 481743018460 Q-loop/lid; other site 481743018461 ABC transporter signature motif; other site 481743018462 Walker B; other site 481743018463 D-loop; other site 481743018464 H-loop/switch region; other site 481743018465 VanW like protein; Region: VanW; pfam04294 481743018466 G5 domain; Region: G5; pfam07501 481743018467 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 481743018468 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 481743018469 S-formylglutathione hydrolase; Region: PLN02442 481743018470 Predicted esterase [General function prediction only]; Region: COG0627 481743018471 argininosuccinate lyase; Provisional; Region: PRK00855 481743018472 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 481743018473 active sites [active] 481743018474 tetramer interface [polypeptide binding]; other site 481743018475 argininosuccinate synthase; Provisional; Region: PRK13820 481743018476 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 481743018477 ANP binding site [chemical binding]; other site 481743018478 Substrate Binding Site II [chemical binding]; other site 481743018479 Substrate Binding Site I [chemical binding]; other site 481743018480 ornithine carbamoyltransferase; Provisional; Region: PRK00779 481743018481 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 481743018482 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 481743018483 acetylornithine aminotransferase; Provisional; Region: PRK02627 481743018484 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 481743018485 inhibitor-cofactor binding pocket; inhibition site 481743018486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743018487 catalytic residue [active] 481743018488 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 481743018489 nucleotide binding site [chemical binding]; other site 481743018490 N-acetyl-L-glutamate binding site [chemical binding]; other site 481743018491 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 481743018492 heterotetramer interface [polypeptide binding]; other site 481743018493 active site pocket [active] 481743018494 cleavage site 481743018495 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 481743018496 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 481743018497 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 481743018498 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 481743018499 Uncharacterized conserved protein [Function unknown]; Region: COG1284 481743018500 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 481743018501 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 481743018502 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 481743018503 peptide chain release factor 2; Provisional; Region: PRK06746 481743018504 This domain is found in peptide chain release factors; Region: PCRF; smart00937 481743018505 RF-1 domain; Region: RF-1; pfam00472 481743018506 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 481743018507 DEAD/DEAH box helicase; Region: DEAD; pfam00270 481743018508 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 481743018509 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481743018510 nucleotide binding region [chemical binding]; other site 481743018511 ATP-binding site [chemical binding]; other site 481743018512 SEC-C motif; Region: SEC-C; pfam02810 481743018513 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 481743018514 30S subunit binding site; other site 481743018515 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 481743018516 DNA-binding site [nucleotide binding]; DNA binding site 481743018517 RNA-binding motif; other site 481743018518 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 481743018519 putative metal binding site; other site 481743018520 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743018521 binding surface 481743018522 TPR motif; other site 481743018523 Tetratricopeptide repeat; Region: TPR_12; pfam13424 481743018524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743018525 binding surface 481743018526 TPR motif; other site 481743018527 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 481743018528 metal ion-dependent adhesion site (MIDAS); other site 481743018529 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 481743018530 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 481743018531 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 481743018532 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 481743018533 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 481743018534 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 481743018535 IPT/TIG domain; Region: TIG; pfam01833 481743018536 Flagellar protein FliS; Region: FliS; cl00654 481743018537 FlaG protein; Region: FlaG; pfam03646 481743018538 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 481743018539 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 481743018540 flagellin; Provisional; Region: PRK12804 481743018541 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 481743018542 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 481743018543 Global regulator protein family; Region: CsrA; pfam02599 481743018544 FliW protein; Region: FliW; pfam02623 481743018545 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 481743018546 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 481743018547 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 481743018548 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 481743018549 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 481743018550 FlgN protein; Region: FlgN; pfam05130 481743018551 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 481743018552 flagellar operon protein TIGR03826; Region: YvyF 481743018553 comF family protein; Region: comF; TIGR00201 481743018554 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 481743018555 active site 481743018556 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481743018557 ATP binding site [chemical binding]; other site 481743018558 putative Mg++ binding site [ion binding]; other site 481743018559 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481743018560 nucleotide binding region [chemical binding]; other site 481743018561 ATP-binding site [chemical binding]; other site 481743018562 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743018563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743018564 active site 481743018565 phosphorylation site [posttranslational modification] 481743018566 intermolecular recognition site; other site 481743018567 dimerization interface [polypeptide binding]; other site 481743018568 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743018569 DNA binding residues [nucleotide binding] 481743018570 dimerization interface [polypeptide binding]; other site 481743018571 Sensor protein DegS; Region: DegS; pfam05384 481743018572 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 481743018573 Histidine kinase; Region: HisKA_3; pfam07730 481743018574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743018575 ATP binding site [chemical binding]; other site 481743018576 Mg2+ binding site [ion binding]; other site 481743018577 G-X-G motif; other site 481743018578 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 481743018579 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 481743018580 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743018581 S-adenosylmethionine synthetase; Validated; Region: PRK05250 481743018582 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 481743018583 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 481743018584 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 481743018585 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 481743018586 S-layer homology domain; Region: SLH; pfam00395 481743018587 S-layer homology domain; Region: SLH; pfam00395 481743018588 S-layer homology domain; Region: SLH; pfam00395 481743018589 S-layer homology domain; Region: SLH; pfam00395 481743018590 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 481743018591 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 481743018592 Mg++ binding site [ion binding]; other site 481743018593 putative catalytic motif [active] 481743018594 substrate binding site [chemical binding]; other site 481743018595 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 481743018596 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 481743018597 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 481743018598 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 481743018599 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 481743018600 active site 481743018601 substrate binding site [chemical binding]; other site 481743018602 metal binding site [ion binding]; metal-binding site 481743018603 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 481743018604 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 481743018605 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 481743018606 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 481743018607 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 481743018608 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 481743018609 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 481743018610 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 481743018611 rod shape-determining protein Mbl; Provisional; Region: PRK13928 481743018612 MreB and similar proteins; Region: MreB_like; cd10225 481743018613 nucleotide binding site [chemical binding]; other site 481743018614 Mg binding site [ion binding]; other site 481743018615 putative protofilament interaction site [polypeptide binding]; other site 481743018616 RodZ interaction site [polypeptide binding]; other site 481743018617 Stage III sporulation protein D; Region: SpoIIID; pfam12116 481743018618 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 481743018619 Peptidase family M23; Region: Peptidase_M23; pfam01551 481743018620 Stage II sporulation protein; Region: SpoIID; pfam08486 481743018621 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 481743018622 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 481743018623 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 481743018624 hinge; other site 481743018625 active site 481743018626 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 481743018627 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 481743018628 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 481743018629 gamma subunit interface [polypeptide binding]; other site 481743018630 epsilon subunit interface [polypeptide binding]; other site 481743018631 LBP interface [polypeptide binding]; other site 481743018632 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 481743018633 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 481743018634 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 481743018635 alpha subunit interaction interface [polypeptide binding]; other site 481743018636 Walker A motif; other site 481743018637 ATP binding site [chemical binding]; other site 481743018638 Walker B motif; other site 481743018639 inhibitor binding site; inhibition site 481743018640 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 481743018641 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 481743018642 core domain interface [polypeptide binding]; other site 481743018643 delta subunit interface [polypeptide binding]; other site 481743018644 epsilon subunit interface [polypeptide binding]; other site 481743018645 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 481743018646 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 481743018647 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 481743018648 beta subunit interaction interface [polypeptide binding]; other site 481743018649 Walker A motif; other site 481743018650 ATP binding site [chemical binding]; other site 481743018651 Walker B motif; other site 481743018652 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 481743018653 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 481743018654 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 481743018655 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 481743018656 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 481743018657 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 481743018658 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 481743018659 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 481743018660 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 481743018661 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 481743018662 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 481743018663 active site 481743018664 homodimer interface [polypeptide binding]; other site 481743018665 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 481743018666 active site 481743018667 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 481743018668 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 481743018669 dimer interface [polypeptide binding]; other site 481743018670 active site 481743018671 glycine-pyridoxal phosphate binding site [chemical binding]; other site 481743018672 folate binding site [chemical binding]; other site 481743018673 hypothetical protein; Provisional; Region: PRK13690 481743018674 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 481743018675 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 481743018676 Low molecular weight phosphatase family; Region: LMWPc; cd00115 481743018677 active site 481743018678 Predicted membrane protein [Function unknown]; Region: COG1971 481743018679 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 481743018680 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 481743018681 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 481743018682 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 481743018683 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 481743018684 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 481743018685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743018686 S-adenosylmethionine binding site [chemical binding]; other site 481743018687 peptide chain release factor 1; Validated; Region: prfA; PRK00591 481743018688 This domain is found in peptide chain release factors; Region: PCRF; smart00937 481743018689 RF-1 domain; Region: RF-1; pfam00472 481743018690 GTP-binding protein YchF; Reviewed; Region: PRK09601 481743018691 YchF GTPase; Region: YchF; cd01900 481743018692 G1 box; other site 481743018693 GTP/Mg2+ binding site [chemical binding]; other site 481743018694 Switch I region; other site 481743018695 G2 box; other site 481743018696 Switch II region; other site 481743018697 G3 box; other site 481743018698 G4 box; other site 481743018699 G5 box; other site 481743018700 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 481743018701 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 481743018702 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 481743018703 homotetramer interface [polypeptide binding]; other site 481743018704 FMN binding site [chemical binding]; other site 481743018705 homodimer contacts [polypeptide binding]; other site 481743018706 putative active site [active] 481743018707 putative substrate binding site [chemical binding]; other site 481743018708 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 481743018709 putative active site [active] 481743018710 putative catalytic site [active] 481743018711 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 481743018712 PLD-like domain; Region: PLDc_2; pfam13091 481743018713 putative active site [active] 481743018714 putative catalytic site [active] 481743018715 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 481743018716 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 481743018717 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 481743018718 putative active site [active] 481743018719 catalytic site [active] 481743018720 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 481743018721 putative active site [active] 481743018722 catalytic site [active] 481743018723 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743018724 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743018725 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 481743018726 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 481743018727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743018728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743018729 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 481743018730 Protein export membrane protein; Region: SecD_SecF; cl14618 481743018731 Protein export membrane protein; Region: SecD_SecF; cl14618 481743018732 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 481743018733 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 481743018734 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743018735 FeS/SAM binding site; other site 481743018736 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 481743018737 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 481743018738 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 481743018739 GTP binding site; other site 481743018740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743018741 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743018742 putative substrate translocation pore; other site 481743018743 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 481743018744 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 481743018745 active site 481743018746 HIGH motif; other site 481743018747 nucleotide binding site [chemical binding]; other site 481743018748 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 481743018749 active site 481743018750 KMSKS motif; other site 481743018751 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 481743018752 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 481743018753 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 481743018754 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 481743018755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 481743018756 MOSC domain; Region: MOSC; pfam03473 481743018757 3-alpha domain; Region: 3-alpha; pfam03475 481743018758 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 481743018759 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481743018760 Coenzyme A binding pocket [chemical binding]; other site 481743018761 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 481743018762 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 481743018763 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 481743018764 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 481743018765 Putative esterase; Region: Esterase; pfam00756 481743018766 S-formylglutathione hydrolase; Region: PLN02442 481743018767 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743018768 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481743018769 DNA binding site [nucleotide binding] 481743018770 domain linker motif; other site 481743018771 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743018772 dimerization interface [polypeptide binding]; other site 481743018773 ligand binding site [chemical binding]; other site 481743018774 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743018775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743018776 dimer interface [polypeptide binding]; other site 481743018777 conserved gate region; other site 481743018778 putative PBP binding loops; other site 481743018779 ABC-ATPase subunit interface; other site 481743018780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743018781 dimer interface [polypeptide binding]; other site 481743018782 conserved gate region; other site 481743018783 putative PBP binding loops; other site 481743018784 ABC-ATPase subunit interface; other site 481743018785 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 481743018786 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743018787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743018788 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743018789 putative substrate translocation pore; other site 481743018790 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743018791 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743018792 dimerization interface [polypeptide binding]; other site 481743018793 Histidine kinase; Region: His_kinase; pfam06580 481743018794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743018795 ATP binding site [chemical binding]; other site 481743018796 Mg2+ binding site [ion binding]; other site 481743018797 G-X-G motif; other site 481743018798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743018799 active site 481743018800 phosphorylation site [posttranslational modification] 481743018801 intermolecular recognition site; other site 481743018802 dimerization interface [polypeptide binding]; other site 481743018803 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481743018804 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743018805 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743018806 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743018807 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743018808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743018809 dimer interface [polypeptide binding]; other site 481743018810 conserved gate region; other site 481743018811 ABC-ATPase subunit interface; other site 481743018812 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743018813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743018814 dimer interface [polypeptide binding]; other site 481743018815 conserved gate region; other site 481743018816 ABC-ATPase subunit interface; other site 481743018817 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 481743018818 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 481743018819 putative [4Fe-4S] binding site [ion binding]; other site 481743018820 putative molybdopterin cofactor binding site [chemical binding]; other site 481743018821 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 481743018822 putative molybdopterin cofactor binding site; other site 481743018823 Amino acid permease; Region: AA_permease_2; pfam13520 481743018824 K+ potassium transporter; Region: K_trans; cl15781 481743018825 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 481743018826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743018827 H+ Antiporter protein; Region: 2A0121; TIGR00900 481743018828 putative substrate translocation pore; other site 481743018829 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743018830 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743018831 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 481743018832 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 481743018833 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 481743018834 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 481743018835 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481743018836 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 481743018837 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 481743018838 NADH(P)-binding; Region: NAD_binding_10; pfam13460 481743018839 NAD(P) binding site [chemical binding]; other site 481743018840 putative active site [active] 481743018841 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 481743018842 catalytic residues [active] 481743018843 dimer interface [polypeptide binding]; other site 481743018844 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 481743018845 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 481743018846 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 481743018847 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 481743018848 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 481743018849 ATP binding site [chemical binding]; other site 481743018850 Mg++ binding site [ion binding]; other site 481743018851 motif III; other site 481743018852 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481743018853 nucleotide binding region [chemical binding]; other site 481743018854 ATP-binding site [chemical binding]; other site 481743018855 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 481743018856 ABC1 family; Region: ABC1; pfam03109 481743018857 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 481743018858 active site 481743018859 ATP binding site [chemical binding]; other site 481743018860 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743018861 substrate binding site [chemical binding]; other site 481743018862 Uncharacterized conserved protein [Function unknown]; Region: COG3937 481743018863 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 481743018864 Predicted membrane protein [Function unknown]; Region: COG3212 481743018865 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 481743018866 Predicted membrane protein [Function unknown]; Region: COG3212 481743018867 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 481743018868 HAMP domain; Region: HAMP; pfam00672 481743018869 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743018870 dimerization interface [polypeptide binding]; other site 481743018871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743018872 dimer interface [polypeptide binding]; other site 481743018873 phosphorylation site [posttranslational modification] 481743018874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743018875 ATP binding site [chemical binding]; other site 481743018876 Mg2+ binding site [ion binding]; other site 481743018877 G-X-G motif; other site 481743018878 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743018879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743018880 active site 481743018881 phosphorylation site [posttranslational modification] 481743018882 intermolecular recognition site; other site 481743018883 dimerization interface [polypeptide binding]; other site 481743018884 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743018885 DNA binding site [nucleotide binding] 481743018886 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 481743018887 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 481743018888 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 481743018889 active site 481743018890 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 481743018891 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 481743018892 tetramer interface [polypeptide binding]; other site 481743018893 heme binding pocket [chemical binding]; other site 481743018894 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743018895 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743018896 DNA binding site [nucleotide binding] 481743018897 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 481743018898 metal binding site 2 [ion binding]; metal-binding site 481743018899 putative DNA binding helix; other site 481743018900 metal binding site 1 [ion binding]; metal-binding site 481743018901 dimer interface [polypeptide binding]; other site 481743018902 structural Zn2+ binding site [ion binding]; other site 481743018903 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 481743018904 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 481743018905 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743018906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743018907 active site 481743018908 phosphorylation site [posttranslational modification] 481743018909 intermolecular recognition site; other site 481743018910 dimerization interface [polypeptide binding]; other site 481743018911 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743018912 DNA binding site [nucleotide binding] 481743018913 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743018914 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743018915 dimerization interface [polypeptide binding]; other site 481743018916 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743018917 dimer interface [polypeptide binding]; other site 481743018918 phosphorylation site [posttranslational modification] 481743018919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743018920 ATP binding site [chemical binding]; other site 481743018921 Mg2+ binding site [ion binding]; other site 481743018922 G-X-G motif; other site 481743018923 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 481743018924 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481743018925 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481743018926 metal binding site [ion binding]; metal-binding site 481743018927 active site 481743018928 I-site; other site 481743018929 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481743018930 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481743018931 active site 481743018932 catalytic tetrad [active] 481743018933 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 481743018934 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 481743018935 Spore germination protein; Region: Spore_permease; cl17796 481743018936 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 481743018937 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 481743018938 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 481743018939 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 481743018940 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 481743018941 [2Fe-2S] cluster binding site [ion binding]; other site 481743018942 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 481743018943 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 481743018944 Transposase IS200 like; Region: Y1_Tnp; pfam01797 481743018945 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743018946 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743018947 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 481743018948 Walker A/P-loop; other site 481743018949 ATP binding site [chemical binding]; other site 481743018950 Q-loop/lid; other site 481743018951 ABC transporter signature motif; other site 481743018952 Walker B; other site 481743018953 D-loop; other site 481743018954 H-loop/switch region; other site 481743018955 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 481743018956 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743018957 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743018958 Walker A/P-loop; other site 481743018959 ATP binding site [chemical binding]; other site 481743018960 Q-loop/lid; other site 481743018961 ABC transporter signature motif; other site 481743018962 Walker B; other site 481743018963 D-loop; other site 481743018964 H-loop/switch region; other site 481743018965 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481743018966 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743018967 putative DNA binding site [nucleotide binding]; other site 481743018968 putative Zn2+ binding site [ion binding]; other site 481743018969 GTPase RsgA; Reviewed; Region: PRK01889 481743018970 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 481743018971 RNA binding site [nucleotide binding]; other site 481743018972 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 481743018973 GTPase/Zn-binding domain interface [polypeptide binding]; other site 481743018974 GTP/Mg2+ binding site [chemical binding]; other site 481743018975 G4 box; other site 481743018976 G5 box; other site 481743018977 G1 box; other site 481743018978 Switch I region; other site 481743018979 G2 box; other site 481743018980 G3 box; other site 481743018981 Switch II region; other site 481743018982 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 481743018983 DEAD_2; Region: DEAD_2; pfam06733 481743018984 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 481743018985 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 481743018986 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 481743018987 NodB motif; other site 481743018988 active site 481743018989 catalytic site [active] 481743018990 Cd binding site [ion binding]; other site 481743018991 putative oxidoreductase; Provisional; Region: PRK11579 481743018992 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481743018993 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481743018994 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 481743018995 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 481743018996 tetramer interface [polypeptide binding]; other site 481743018997 heme binding pocket [chemical binding]; other site 481743018998 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743018999 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743019000 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 481743019001 putative dimerization interface [polypeptide binding]; other site 481743019002 LrgA family; Region: LrgA; cl00608 481743019003 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 481743019004 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 481743019005 DIE2/ALG10 family; Region: DIE2_ALG10; pfam04922 481743019006 Sulfatase; Region: Sulfatase; pfam00884 481743019007 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 481743019008 Domain of unknown function DUF21; Region: DUF21; pfam01595 481743019009 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 481743019010 Transporter associated domain; Region: CorC_HlyC; smart01091 481743019011 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 481743019012 fumarate hydratase; Reviewed; Region: fumC; PRK00485 481743019013 Class II fumarases; Region: Fumarase_classII; cd01362 481743019014 active site 481743019015 tetramer interface [polypeptide binding]; other site 481743019016 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 481743019017 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 481743019018 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 481743019019 Walker A/P-loop; other site 481743019020 ATP binding site [chemical binding]; other site 481743019021 Q-loop/lid; other site 481743019022 ABC transporter signature motif; other site 481743019023 Walker B; other site 481743019024 D-loop; other site 481743019025 H-loop/switch region; other site 481743019026 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481743019027 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 481743019028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743019029 Walker A/P-loop; other site 481743019030 ATP binding site [chemical binding]; other site 481743019031 Q-loop/lid; other site 481743019032 ABC transporter signature motif; other site 481743019033 Walker B; other site 481743019034 D-loop; other site 481743019035 H-loop/switch region; other site 481743019036 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 481743019037 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 481743019038 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 481743019039 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 481743019040 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 481743019041 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 481743019042 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 481743019043 active site 481743019044 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 481743019045 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 481743019046 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 481743019047 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743019048 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743019049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743019050 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743019051 putative substrate translocation pore; other site 481743019052 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743019053 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743019054 dimer interface [polypeptide binding]; other site 481743019055 phosphorylation site [posttranslational modification] 481743019056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743019057 ATP binding site [chemical binding]; other site 481743019058 Mg2+ binding site [ion binding]; other site 481743019059 G-X-G motif; other site 481743019060 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743019061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743019062 active site 481743019063 phosphorylation site [posttranslational modification] 481743019064 intermolecular recognition site; other site 481743019065 dimerization interface [polypeptide binding]; other site 481743019066 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743019067 DNA binding site [nucleotide binding] 481743019068 Predicted membrane protein [Function unknown]; Region: COG2311 481743019069 Protein of unknown function (DUF418); Region: DUF418; cl12135 481743019070 Protein of unknown function (DUF418); Region: DUF418; pfam04235 481743019071 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 481743019072 Protein of unknown function (DUF4023); Region: DUF4023; pfam13215 481743019073 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 481743019074 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 481743019075 dimer interface [polypeptide binding]; other site 481743019076 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 481743019077 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743019078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 481743019079 CGNR zinc finger; Region: zf-CGNR; pfam11706 481743019080 Epoxide hydrolase N terminus; Region: EHN; pfam06441 481743019081 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 481743019082 AAA domain; Region: AAA_17; cl17253 481743019083 topology modulation protein; Reviewed; Region: PRK08118 481743019084 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 481743019085 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 481743019086 dimer interface [polypeptide binding]; other site 481743019087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743019088 catalytic residue [active] 481743019089 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 481743019090 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 481743019091 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 481743019092 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 481743019093 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 481743019094 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 481743019095 Amidase; Region: Amidase; cl11426 481743019096 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743019097 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743019098 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 481743019099 Glyco_18 domain; Region: Glyco_18; smart00636 481743019100 active site 481743019101 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 481743019102 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 481743019103 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 481743019104 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 481743019105 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 481743019106 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 481743019107 putative ligand binding site [chemical binding]; other site 481743019108 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 481743019109 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 481743019110 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 481743019111 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 481743019112 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743019113 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743019114 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743019115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743019116 dimer interface [polypeptide binding]; other site 481743019117 conserved gate region; other site 481743019118 putative PBP binding loops; other site 481743019119 ABC-ATPase subunit interface; other site 481743019120 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743019121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743019122 dimer interface [polypeptide binding]; other site 481743019123 conserved gate region; other site 481743019124 putative PBP binding loops; other site 481743019125 ABC-ATPase subunit interface; other site 481743019126 Glyco_18 domain; Region: Glyco_18; smart00636 481743019127 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 481743019128 active site 481743019129 Domain of unknown function (DUF378); Region: DUF378; pfam04070 481743019130 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743019131 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743019132 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 481743019133 putative dimerization interface [polypeptide binding]; other site 481743019134 Predicted membrane protein [Function unknown]; Region: COG2855 481743019135 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 481743019136 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 481743019137 active site 481743019138 Na/Ca binding site [ion binding]; other site 481743019139 catalytic site [active] 481743019140 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 481743019141 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 481743019142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743019143 dimer interface [polypeptide binding]; other site 481743019144 conserved gate region; other site 481743019145 putative PBP binding loops; other site 481743019146 ABC-ATPase subunit interface; other site 481743019147 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 481743019148 catalytic residues [active] 481743019149 dimer interface [polypeptide binding]; other site 481743019150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 481743019151 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 481743019152 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743019153 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743019154 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 481743019155 dimer interface [polypeptide binding]; other site 481743019156 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 481743019157 putative hydrophobic ligand binding site [chemical binding]; other site 481743019158 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743019159 dimerization interface [polypeptide binding]; other site 481743019160 putative DNA binding site [nucleotide binding]; other site 481743019161 putative Zn2+ binding site [ion binding]; other site 481743019162 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 481743019163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743019164 motif II; other site 481743019165 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 481743019166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743019167 S-adenosylmethionine binding site [chemical binding]; other site 481743019168 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 481743019169 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 481743019170 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 481743019171 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 481743019172 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 481743019173 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 481743019174 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 481743019175 Na binding site [ion binding]; other site 481743019176 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 481743019177 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 481743019178 Na binding site [ion binding]; other site 481743019179 Protein of unknown function, DUF485; Region: DUF485; pfam04341 481743019180 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 481743019181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743019182 active site 481743019183 phosphorylation site [posttranslational modification] 481743019184 intermolecular recognition site; other site 481743019185 dimerization interface [polypeptide binding]; other site 481743019186 LytTr DNA-binding domain; Region: LytTR; pfam04397 481743019187 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 481743019188 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 481743019189 GAF domain; Region: GAF_3; pfam13492 481743019190 Histidine kinase; Region: His_kinase; pfam06580 481743019191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743019192 ATP binding site [chemical binding]; other site 481743019193 Mg2+ binding site [ion binding]; other site 481743019194 G-X-G motif; other site 481743019195 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 481743019196 Uncharacterized conserved protein [Function unknown]; Region: COG2966 481743019197 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 481743019198 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481743019199 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481743019200 active site 481743019201 catalytic tetrad [active] 481743019202 Predicted transcriptional regulators [Transcription]; Region: COG1695 481743019203 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 481743019204 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 481743019205 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481743019206 Walker A/P-loop; other site 481743019207 ATP binding site [chemical binding]; other site 481743019208 Q-loop/lid; other site 481743019209 ABC transporter signature motif; other site 481743019210 Walker B; other site 481743019211 D-loop; other site 481743019212 H-loop/switch region; other site 481743019213 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 481743019214 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 481743019215 seryl-tRNA synthetase; Provisional; Region: PRK05431 481743019216 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 481743019217 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 481743019218 dimer interface [polypeptide binding]; other site 481743019219 active site 481743019220 motif 1; other site 481743019221 motif 2; other site 481743019222 motif 3; other site 481743019223 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 481743019224 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 481743019225 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 481743019226 short chain dehydrogenase; Provisional; Region: PRK06172 481743019227 classical (c) SDRs; Region: SDR_c; cd05233 481743019228 NAD(P) binding site [chemical binding]; other site 481743019229 active site 481743019230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743019231 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 481743019232 NAD(P) binding site [chemical binding]; other site 481743019233 active site 481743019234 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481743019235 MarR family; Region: MarR; pfam01047 481743019236 Helix-turn-helix domain; Region: HTH_28; pfam13518 481743019237 putative transposase OrfB; Reviewed; Region: PHA02517 481743019238 HTH-like domain; Region: HTH_21; pfam13276 481743019239 Integrase core domain; Region: rve; pfam00665 481743019240 Integrase core domain; Region: rve_3; pfam13683 481743019241 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 481743019242 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 481743019243 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 481743019244 metal-binding site [ion binding] 481743019245 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 481743019246 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 481743019247 metal-binding site [ion binding] 481743019248 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 481743019249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743019250 motif II; other site 481743019251 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 481743019252 metal-binding site [ion binding] 481743019253 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 481743019254 putative homodimer interface [polypeptide binding]; other site 481743019255 putative homotetramer interface [polypeptide binding]; other site 481743019256 allosteric switch controlling residues; other site 481743019257 putative metal binding site [ion binding]; other site 481743019258 putative homodimer-homodimer interface [polypeptide binding]; other site 481743019259 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 481743019260 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 481743019261 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 481743019262 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 481743019263 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743019264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743019265 dimer interface [polypeptide binding]; other site 481743019266 conserved gate region; other site 481743019267 ABC-ATPase subunit interface; other site 481743019268 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743019269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743019270 dimer interface [polypeptide binding]; other site 481743019271 conserved gate region; other site 481743019272 ABC-ATPase subunit interface; other site 481743019273 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743019274 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743019275 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743019276 HAMP domain; Region: HAMP; pfam00672 481743019277 dimerization interface [polypeptide binding]; other site 481743019278 Histidine kinase; Region: His_kinase; pfam06580 481743019279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743019280 ATP binding site [chemical binding]; other site 481743019281 Mg2+ binding site [ion binding]; other site 481743019282 G-X-G motif; other site 481743019283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743019284 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 481743019285 active site 481743019286 phosphorylation site [posttranslational modification] 481743019287 intermolecular recognition site; other site 481743019288 dimerization interface [polypeptide binding]; other site 481743019289 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743019290 Glucuronate isomerase; Region: UxaC; pfam02614 481743019291 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 481743019292 Transcriptional regulators [Transcription]; Region: GntR; COG1802 481743019293 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743019294 DNA-binding site [nucleotide binding]; DNA binding site 481743019295 FCD domain; Region: FCD; pfam07729 481743019296 mannonate dehydratase; Provisional; Region: PRK03906 481743019297 mannonate dehydratase; Region: uxuA; TIGR00695 481743019298 D-mannonate oxidoreductase; Provisional; Region: PRK08277 481743019299 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 481743019300 putative NAD(P) binding site [chemical binding]; other site 481743019301 active site 481743019302 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 481743019303 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 481743019304 NAD binding site [chemical binding]; other site 481743019305 sugar binding site [chemical binding]; other site 481743019306 divalent metal binding site [ion binding]; other site 481743019307 tetramer (dimer of dimers) interface [polypeptide binding]; other site 481743019308 dimer interface [polypeptide binding]; other site 481743019309 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 481743019310 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481743019311 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481743019312 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743019313 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 481743019314 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 481743019315 homodimer interface [polypeptide binding]; other site 481743019316 substrate-cofactor binding pocket; other site 481743019317 catalytic residue [active] 481743019318 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481743019319 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481743019320 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 481743019321 dimerization interface [polypeptide binding]; other site 481743019322 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 481743019323 Predicted acetyltransferase [General function prediction only]; Region: COG5628 481743019324 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 481743019325 Phosphotransferase enzyme family; Region: APH; pfam01636 481743019326 putative active site [active] 481743019327 putative substrate binding site [chemical binding]; other site 481743019328 ATP binding site [chemical binding]; other site 481743019329 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 481743019330 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481743019331 FeS/SAM binding site; other site 481743019332 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 481743019333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743019334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743019335 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 481743019336 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 481743019337 putative active site [active] 481743019338 putative metal binding site [ion binding]; other site 481743019339 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 481743019340 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 481743019341 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 481743019342 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 481743019343 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 481743019344 Uncharacterized conserved protein [Function unknown]; Region: COG3379 481743019345 Sulfatase; Region: Sulfatase; cl17466 481743019346 Isochorismatase family; Region: Isochorismatase; pfam00857 481743019347 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 481743019348 catalytic triad [active] 481743019349 conserved cis-peptide bond; other site 481743019350 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481743019351 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743019352 putative Zn2+ binding site [ion binding]; other site 481743019353 putative DNA binding site [nucleotide binding]; other site 481743019354 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743019355 DNA-binding site [nucleotide binding]; DNA binding site 481743019356 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481743019357 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 481743019358 ligand binding site [chemical binding]; other site 481743019359 dimerization interface [polypeptide binding]; other site 481743019360 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 481743019361 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 481743019362 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 481743019363 Spore germination protein; Region: Spore_permease; pfam03845 481743019364 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 481743019365 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 481743019366 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743019367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743019368 active site 481743019369 phosphorylation site [posttranslational modification] 481743019370 intermolecular recognition site; other site 481743019371 dimerization interface [polypeptide binding]; other site 481743019372 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743019373 DNA binding site [nucleotide binding] 481743019374 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743019375 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 481743019376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743019377 ATP binding site [chemical binding]; other site 481743019378 Mg2+ binding site [ion binding]; other site 481743019379 G-X-G motif; other site 481743019380 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 481743019381 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 481743019382 Walker A/P-loop; other site 481743019383 ATP binding site [chemical binding]; other site 481743019384 Q-loop/lid; other site 481743019385 ABC transporter signature motif; other site 481743019386 Walker B; other site 481743019387 D-loop; other site 481743019388 H-loop/switch region; other site 481743019389 FtsX-like permease family; Region: FtsX; pfam02687 481743019390 Predicted membrane protein [Function unknown]; Region: COG2311 481743019391 Protein of unknown function (DUF418); Region: DUF418; cl12135 481743019392 Protein of unknown function (DUF418); Region: DUF418; pfam04235 481743019393 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 481743019394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743019395 DNA-binding site [nucleotide binding]; DNA binding site 481743019396 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481743019397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481743019398 homodimer interface [polypeptide binding]; other site 481743019399 catalytic residue [active] 481743019400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743019401 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743019402 putative substrate translocation pore; other site 481743019403 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 481743019404 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 481743019405 conserved cys residue [active] 481743019406 Fibrobacter succinogenes paralogous family TIGR02172; Region: Fb_sc_TIGR02172 481743019407 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 481743019408 active site 481743019409 substrate binding site [chemical binding]; other site 481743019410 ATP binding site [chemical binding]; other site 481743019411 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 481743019412 SnoaL-like domain; Region: SnoaL_3; pfam13474 481743019413 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 481743019414 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 481743019415 DNA binding residues [nucleotide binding] 481743019416 drug binding residues [chemical binding]; other site 481743019417 dimer interface [polypeptide binding]; other site 481743019418 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 481743019419 short chain dehydrogenase; Provisional; Region: PRK12747 481743019420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743019421 NAD(P) binding site [chemical binding]; other site 481743019422 active site 481743019423 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 481743019424 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743019425 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743019426 DNA binding residues [nucleotide binding] 481743019427 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 481743019428 type III secretion system protein SsaQ; Validated; Region: PRK08035 481743019429 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 481743019430 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 481743019431 active site 481743019432 HIGH motif; other site 481743019433 dimer interface [polypeptide binding]; other site 481743019434 KMSKS motif; other site 481743019435 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 481743019436 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 481743019437 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 481743019438 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 481743019439 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 481743019440 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481743019441 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481743019442 Walker A/P-loop; other site 481743019443 ATP binding site [chemical binding]; other site 481743019444 Q-loop/lid; other site 481743019445 ABC transporter signature motif; other site 481743019446 Walker B; other site 481743019447 D-loop; other site 481743019448 H-loop/switch region; other site 481743019449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 481743019450 Histidine kinase; Region: HisKA_3; pfam07730 481743019451 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 481743019452 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743019453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743019454 active site 481743019455 phosphorylation site [posttranslational modification] 481743019456 intermolecular recognition site; other site 481743019457 dimerization interface [polypeptide binding]; other site 481743019458 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743019459 DNA binding residues [nucleotide binding] 481743019460 dimerization interface [polypeptide binding]; other site 481743019461 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 481743019462 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 481743019463 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743019464 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 481743019465 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 481743019466 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 481743019467 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 481743019468 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 481743019469 Walker A/P-loop; other site 481743019470 ATP binding site [chemical binding]; other site 481743019471 Q-loop/lid; other site 481743019472 ABC transporter signature motif; other site 481743019473 Walker B; other site 481743019474 D-loop; other site 481743019475 H-loop/switch region; other site 481743019476 BCCT family transporter; Region: BCCT; pfam02028 481743019477 Predicted transcriptional regulators [Transcription]; Region: COG1733 481743019478 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 481743019479 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 481743019480 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 481743019481 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743019482 Zn binding site [ion binding]; other site 481743019483 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 481743019484 Zn binding site [ion binding]; other site 481743019485 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 481743019486 active site 481743019487 catalytic residues [active] 481743019488 metal binding site [ion binding]; metal-binding site 481743019489 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 481743019490 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 481743019491 EamA-like transporter family; Region: EamA; pfam00892 481743019492 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743019493 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743019494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743019495 active site 481743019496 phosphorylation site [posttranslational modification] 481743019497 intermolecular recognition site; other site 481743019498 dimerization interface [polypeptide binding]; other site 481743019499 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743019500 DNA binding site [nucleotide binding] 481743019501 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743019502 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 481743019503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743019504 ATP binding site [chemical binding]; other site 481743019505 Mg2+ binding site [ion binding]; other site 481743019506 G-X-G motif; other site 481743019507 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 481743019508 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 481743019509 Walker A/P-loop; other site 481743019510 ATP binding site [chemical binding]; other site 481743019511 Q-loop/lid; other site 481743019512 ABC transporter signature motif; other site 481743019513 Walker B; other site 481743019514 D-loop; other site 481743019515 H-loop/switch region; other site 481743019516 FtsX-like permease family; Region: FtsX; pfam02687 481743019517 DinB superfamily; Region: DinB_2; pfam12867 481743019518 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 481743019519 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481743019520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743019521 putative substrate translocation pore; other site 481743019522 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481743019523 MarR family; Region: MarR_2; pfam12802 481743019524 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 481743019525 FAD binding domain; Region: FAD_binding_4; pfam01565 481743019526 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 481743019527 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 481743019528 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 481743019529 dimer interface [polypeptide binding]; other site 481743019530 active site 481743019531 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 481743019532 substrate binding site [chemical binding]; other site 481743019533 catalytic residue [active] 481743019534 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481743019535 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 481743019536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743019537 active site 481743019538 motif I; other site 481743019539 motif II; other site 481743019540 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 481743019541 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 481743019542 ligand binding site [chemical binding]; other site 481743019543 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 481743019544 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 481743019545 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481743019546 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481743019547 DNA binding residues [nucleotide binding] 481743019548 Putative zinc-finger; Region: zf-HC2; pfam13490 481743019549 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 481743019550 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 481743019551 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 481743019552 hydrophobic ligand binding site; other site 481743019553 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481743019554 dimerization interface [polypeptide binding]; other site 481743019555 putative DNA binding site [nucleotide binding]; other site 481743019556 putative Zn2+ binding site [ion binding]; other site 481743019557 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 481743019558 GIY-YIG motif/motif A; other site 481743019559 active site 481743019560 catalytic site [active] 481743019561 putative DNA binding site [nucleotide binding]; other site 481743019562 metal binding site [ion binding]; metal-binding site 481743019563 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 481743019564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743019565 putative substrate translocation pore; other site 481743019566 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 481743019567 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 481743019568 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 481743019569 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 481743019570 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 481743019571 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 481743019572 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 481743019573 active site 481743019574 phosphorylation site [posttranslational modification] 481743019575 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 481743019576 HTH domain; Region: HTH_11; pfam08279 481743019577 PRD domain; Region: PRD; pfam00874 481743019578 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 481743019579 active site 481743019580 P-loop; other site 481743019581 phosphorylation site [posttranslational modification] 481743019582 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 481743019583 active site 481743019584 phosphorylation site [posttranslational modification] 481743019585 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 481743019586 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 481743019587 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 481743019588 active site 481743019589 P-loop; other site 481743019590 phosphorylation site [posttranslational modification] 481743019591 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 481743019592 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 481743019593 phosphopeptide binding site; other site 481743019594 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743019595 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743019596 DNA binding site [nucleotide binding] 481743019597 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 481743019598 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 481743019599 active site 481743019600 catalytic site [active] 481743019601 ribonuclease Y; Region: RNase_Y; TIGR03319 481743019602 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 481743019603 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 481743019604 NodB motif; other site 481743019605 active site 481743019606 catalytic site [active] 481743019607 metal binding site [ion binding]; metal-binding site 481743019608 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 481743019609 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 481743019610 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 481743019611 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 481743019612 PhnA protein; Region: PhnA; pfam03831 481743019613 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 481743019614 putative NAD(P) binding site [chemical binding]; other site 481743019615 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 481743019616 active site 481743019617 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 481743019618 DinB superfamily; Region: DinB_2; pfam12867 481743019619 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 481743019620 Predicted transcriptional regulator [Transcription]; Region: COG2378 481743019621 HTH domain; Region: HTH_11; pfam08279 481743019622 WYL domain; Region: WYL; pfam13280 481743019623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481743019624 S-adenosylmethionine binding site [chemical binding]; other site 481743019625 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 481743019626 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 481743019627 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 481743019628 PAS domain; Region: PAS; smart00091 481743019629 PAS domain; Region: PAS_9; pfam13426 481743019630 putative active site [active] 481743019631 heme pocket [chemical binding]; other site 481743019632 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481743019633 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481743019634 metal binding site [ion binding]; metal-binding site 481743019635 active site 481743019636 I-site; other site 481743019637 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 481743019638 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 481743019639 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 481743019640 DXD motif; other site 481743019641 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 481743019642 Acyltransferase family; Region: Acyl_transf_3; pfam01757 481743019643 Glyco_18 domain; Region: Glyco_18; smart00636 481743019644 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 481743019645 active site 481743019646 metal-dependent hydrolase; Provisional; Region: PRK13291 481743019647 DinB superfamily; Region: DinB_2; pfam12867 481743019648 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 481743019649 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 481743019650 DNA binding residues [nucleotide binding] 481743019651 putative dimer interface [polypeptide binding]; other site 481743019652 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 481743019653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481743019654 NAD(P) binding site [chemical binding]; other site 481743019655 active site 481743019656 Phosphotransferase enzyme family; Region: APH; pfam01636 481743019657 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 481743019658 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481743019659 Uncharacterized conserved protein [Function unknown]; Region: COG0397 481743019660 hypothetical protein; Validated; Region: PRK00029 481743019661 Bax inhibitor 1 like; Region: BaxI_1; cl17691 481743019662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481743019663 binding surface 481743019664 Tetratricopeptide repeat; Region: TPR_16; pfam13432 481743019665 TPR motif; other site 481743019666 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 481743019667 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 481743019668 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 481743019669 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 481743019670 S-layer homology domain; Region: SLH; pfam00395 481743019671 S-layer homology domain; Region: SLH; pfam00395 481743019672 S-layer homology domain; Region: SLH; pfam00395 481743019673 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743019674 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 481743019675 active site 481743019676 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 481743019677 putative metal binding site [ion binding]; other site 481743019678 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 481743019679 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 481743019680 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 481743019681 Predicted membrane protein [Function unknown]; Region: COG2311 481743019682 Protein of unknown function (DUF418); Region: DUF418; pfam04235 481743019683 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481743019684 Histidine kinase; Region: HisKA_3; pfam07730 481743019685 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 481743019686 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481743019687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743019688 active site 481743019689 phosphorylation site [posttranslational modification] 481743019690 intermolecular recognition site; other site 481743019691 dimerization interface [polypeptide binding]; other site 481743019692 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481743019693 DNA binding residues [nucleotide binding] 481743019694 dimerization interface [polypeptide binding]; other site 481743019695 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 481743019696 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 481743019697 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 481743019698 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 481743019699 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 481743019700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743019701 dimer interface [polypeptide binding]; other site 481743019702 phosphorylation site [posttranslational modification] 481743019703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743019704 ATP binding site [chemical binding]; other site 481743019705 Mg2+ binding site [ion binding]; other site 481743019706 G-X-G motif; other site 481743019707 Response regulator receiver domain; Region: Response_reg; pfam00072 481743019708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743019709 active site 481743019710 phosphorylation site [posttranslational modification] 481743019711 intermolecular recognition site; other site 481743019712 dimerization interface [polypeptide binding]; other site 481743019713 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743019714 Histidine kinase; Region: His_kinase; pfam06580 481743019715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743019716 ATP binding site [chemical binding]; other site 481743019717 Mg2+ binding site [ion binding]; other site 481743019718 G-X-G motif; other site 481743019719 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 481743019720 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 481743019721 putative active site [active] 481743019722 FOG: PKD repeat [General function prediction only]; Region: COG3291 481743019723 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 481743019724 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 481743019725 sugar binding site [chemical binding]; other site 481743019726 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743019727 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 481743019728 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743019729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743019730 putative PBP binding loops; other site 481743019731 ABC-ATPase subunit interface; other site 481743019732 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481743019733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743019734 dimer interface [polypeptide binding]; other site 481743019735 conserved gate region; other site 481743019736 ABC-ATPase subunit interface; other site 481743019737 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 481743019738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743019739 active site 481743019740 phosphorylation site [posttranslational modification] 481743019741 intermolecular recognition site; other site 481743019742 dimerization interface [polypeptide binding]; other site 481743019743 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481743019744 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743019745 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743019746 dimerization interface [polypeptide binding]; other site 481743019747 Histidine kinase; Region: His_kinase; pfam06580 481743019748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743019749 ATP binding site [chemical binding]; other site 481743019750 Mg2+ binding site [ion binding]; other site 481743019751 G-X-G motif; other site 481743019752 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 481743019753 Mga helix-turn-helix domain; Region: Mga; pfam05043 481743019754 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 481743019755 active site 481743019756 P-loop; other site 481743019757 phosphorylation site [posttranslational modification] 481743019758 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 481743019759 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 481743019760 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 481743019761 Cobalt transport protein; Region: CbiQ; cl00463 481743019762 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 481743019763 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 481743019764 Walker A/P-loop; other site 481743019765 ATP binding site [chemical binding]; other site 481743019766 Q-loop/lid; other site 481743019767 ABC transporter signature motif; other site 481743019768 Walker B; other site 481743019769 D-loop; other site 481743019770 H-loop/switch region; other site 481743019771 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 481743019772 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 481743019773 Walker A/P-loop; other site 481743019774 ATP binding site [chemical binding]; other site 481743019775 Q-loop/lid; other site 481743019776 ABC transporter signature motif; other site 481743019777 Walker B; other site 481743019778 D-loop; other site 481743019779 H-loop/switch region; other site 481743019780 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 481743019781 active site 481743019782 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 481743019783 active site 481743019784 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 481743019785 Fe-S cluster binding site [ion binding]; other site 481743019786 active site 481743019787 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 481743019788 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 481743019789 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 481743019790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743019791 putative substrate translocation pore; other site 481743019792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481743019793 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 481743019794 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 481743019795 putative hydrophobic ligand binding site [chemical binding]; other site 481743019796 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 481743019797 putative hydrophobic ligand binding site [chemical binding]; other site 481743019798 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 481743019799 DNA binding residues [nucleotide binding] 481743019800 putative dimer interface [polypeptide binding]; other site 481743019801 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 481743019802 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 481743019803 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 481743019804 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481743019805 MarR family; Region: MarR_2; pfam12802 481743019806 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 481743019807 active site 481743019808 catalytic site [active] 481743019809 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 481743019810 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 481743019811 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 481743019812 active site 481743019813 metal binding site [ion binding]; metal-binding site 481743019814 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 481743019815 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 481743019816 active site 481743019817 catalytic triad [active] 481743019818 oxyanion hole [active] 481743019819 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 481743019820 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481743019821 active site 481743019822 motif I; other site 481743019823 motif II; other site 481743019824 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 481743019825 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481743019826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743019827 dimer interface [polypeptide binding]; other site 481743019828 conserved gate region; other site 481743019829 putative PBP binding loops; other site 481743019830 ABC-ATPase subunit interface; other site 481743019831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743019832 dimer interface [polypeptide binding]; other site 481743019833 conserved gate region; other site 481743019834 putative PBP binding loops; other site 481743019835 ABC-ATPase subunit interface; other site 481743019836 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481743019837 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481743019838 Uncharacterized conserved protein [Function unknown]; Region: COG1434 481743019839 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 481743019840 putative active site [active] 481743019841 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 481743019842 non-specific DNA interactions [nucleotide binding]; other site 481743019843 DNA binding site [nucleotide binding] 481743019844 sequence specific DNA binding site [nucleotide binding]; other site 481743019845 putative cAMP binding site [chemical binding]; other site 481743019846 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 481743019847 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 481743019848 nucleotide binding site [chemical binding]; other site 481743019849 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 481743019850 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 481743019851 nudix motif; other site 481743019852 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 481743019853 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 481743019854 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 481743019855 active site 481743019856 nucleotide binding site [chemical binding]; other site 481743019857 HIGH motif; other site 481743019858 KMSKS motif; other site 481743019859 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 481743019860 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 481743019861 hypothetical protein; Provisional; Region: PRK06851 481743019862 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 481743019863 NTPase; Region: NTPase_1; cl17478 481743019864 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481743019865 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 481743019866 active site 481743019867 metal binding site [ion binding]; metal-binding site 481743019868 HTH domain; Region: HTH_11; pfam08279 481743019869 WYL domain; Region: WYL; pfam13280 481743019870 Domain of unknown function DUF87; Region: DUF87; pfam01935 481743019871 AAA-like domain; Region: AAA_10; pfam12846 481743019872 FRG domain; Region: FRG; pfam08867 481743019873 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 481743019874 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 481743019875 Cytochrome P450; Region: p450; cl12078 481743019876 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481743019877 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481743019878 HEAT repeats; Region: HEAT_2; pfam13646 481743019879 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 481743019880 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 481743019881 G1 box; other site 481743019882 GTP/Mg2+ binding site [chemical binding]; other site 481743019883 G2 box; other site 481743019884 Switch I region; other site 481743019885 G3 box; other site 481743019886 Switch II region; other site 481743019887 G4 box; other site 481743019888 G5 box; other site 481743019889 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 481743019890 YyzF-like protein; Region: YyzF; pfam14116 481743019891 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 481743019892 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 481743019893 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 481743019894 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 481743019895 YycH protein; Region: YycI; cl02015 481743019896 YycH protein; Region: YycH; pfam07435 481743019897 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 481743019898 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743019899 dimerization interface [polypeptide binding]; other site 481743019900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481743019901 putative active site [active] 481743019902 heme pocket [chemical binding]; other site 481743019903 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743019904 dimer interface [polypeptide binding]; other site 481743019905 phosphorylation site [posttranslational modification] 481743019906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743019907 ATP binding site [chemical binding]; other site 481743019908 Mg2+ binding site [ion binding]; other site 481743019909 G-X-G motif; other site 481743019910 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743019911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743019912 active site 481743019913 phosphorylation site [posttranslational modification] 481743019914 intermolecular recognition site; other site 481743019915 dimerization interface [polypeptide binding]; other site 481743019916 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743019917 DNA binding site [nucleotide binding] 481743019918 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 481743019919 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 481743019920 G5 domain; Region: G5; pfam07501 481743019921 Peptidase family M23; Region: Peptidase_M23; pfam01551 481743019922 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481743019923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481743019924 active site 481743019925 phosphorylation site [posttranslational modification] 481743019926 intermolecular recognition site; other site 481743019927 dimerization interface [polypeptide binding]; other site 481743019928 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481743019929 DNA binding site [nucleotide binding] 481743019930 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 481743019931 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481743019932 dimerization interface [polypeptide binding]; other site 481743019933 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481743019934 dimer interface [polypeptide binding]; other site 481743019935 phosphorylation site [posttranslational modification] 481743019936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481743019937 ATP binding site [chemical binding]; other site 481743019938 Mg2+ binding site [ion binding]; other site 481743019939 G-X-G motif; other site 481743019940 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 481743019941 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 481743019942 FtsX-like permease family; Region: FtsX; pfam02687 481743019943 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 481743019944 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 481743019945 Walker A/P-loop; other site 481743019946 ATP binding site [chemical binding]; other site 481743019947 Q-loop/lid; other site 481743019948 ABC transporter signature motif; other site 481743019949 Walker B; other site 481743019950 D-loop; other site 481743019951 H-loop/switch region; other site 481743019952 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 481743019953 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 481743019954 GDP-binding site [chemical binding]; other site 481743019955 ACT binding site; other site 481743019956 IMP binding site; other site 481743019957 replicative DNA helicase; Provisional; Region: PRK05748 481743019958 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 481743019959 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 481743019960 Walker A motif; other site 481743019961 ATP binding site [chemical binding]; other site 481743019962 Walker B motif; other site 481743019963 DNA binding loops [nucleotide binding] 481743019964 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 481743019965 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 481743019966 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 481743019967 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 481743019968 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 481743019969 DHH family; Region: DHH; pfam01368 481743019970 DHHA1 domain; Region: DHHA1; pfam02272 481743019971 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 481743019972 MazG-like family; Region: MazG-like; pfam12643 481743019973 FOG: CBS domain [General function prediction only]; Region: COG0517 481743019974 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 481743019975 Transcriptional regulator [Transcription]; Region: LytR; COG1316 481743019976 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 481743019977 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 481743019978 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 481743019979 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743019980 Walker A/P-loop; other site 481743019981 ATP binding site [chemical binding]; other site 481743019982 Q-loop/lid; other site 481743019983 ABC transporter signature motif; other site 481743019984 Walker B; other site 481743019985 D-loop; other site 481743019986 H-loop/switch region; other site 481743019987 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 481743019988 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 481743019989 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481743019990 Walker A/P-loop; other site 481743019991 ATP binding site [chemical binding]; other site 481743019992 Q-loop/lid; other site 481743019993 ABC transporter signature motif; other site 481743019994 Walker B; other site 481743019995 D-loop; other site 481743019996 H-loop/switch region; other site 481743019997 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 481743019998 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 481743019999 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 481743020000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743020001 dimer interface [polypeptide binding]; other site 481743020002 conserved gate region; other site 481743020003 putative PBP binding loops; other site 481743020004 ABC-ATPase subunit interface; other site 481743020005 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 481743020006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481743020007 dimer interface [polypeptide binding]; other site 481743020008 conserved gate region; other site 481743020009 putative PBP binding loops; other site 481743020010 ABC-ATPase subunit interface; other site 481743020011 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 481743020012 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 481743020013 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 481743020014 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 481743020015 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 481743020016 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 481743020017 dimer interface [polypeptide binding]; other site 481743020018 ssDNA binding site [nucleotide binding]; other site 481743020019 tetramer (dimer of dimers) interface [polypeptide binding]; other site 481743020020 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 481743020021 YjzC-like protein; Region: YjzC; pfam14168 481743020022 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 481743020023 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 481743020024 Mechanosensitive ion channel; Region: MS_channel; pfam00924 481743020025 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 481743020026 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 481743020027 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 481743020028 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 481743020029 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 481743020030 catalytic residue [active] 481743020031 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 481743020032 ParB-like nuclease domain; Region: ParB; smart00470 481743020033 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 481743020034 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 481743020035 P-loop; other site 481743020036 Magnesium ion binding site [ion binding]; other site 481743020037 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 481743020038 Magnesium ion binding site [ion binding]; other site 481743020039 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 481743020040 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 481743020041 ParB-like nuclease domain; Region: ParB; smart00470 481743020042 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 481743020043 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 481743020044 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 481743020045 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 481743020046 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 481743020047 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 481743020048 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 481743020049 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 481743020050 GTP/Mg2+ binding site [chemical binding]; other site 481743020051 G5 box; other site 481743020052 trmE is a tRNA modification GTPase; Region: trmE; cd04164 481743020053 G1 box; other site 481743020054 G1 box; other site 481743020055 GTP/Mg2+ binding site [chemical binding]; other site 481743020056 Switch I region; other site 481743020057 Switch I region; other site 481743020058 G2 box; other site 481743020059 G2 box; other site 481743020060 Switch II region; other site 481743020061 G3 box; other site 481743020062 G3 box; other site 481743020063 Switch II region; other site 481743020064 G4 box; other site 481743020065 G5 box; other site 481743020066 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 481743020067 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 481743020068 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 481743020069 G-X-X-G motif; other site 481743020070 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 481743020071 RxxxH motif; other site 481743020072 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 481743020073 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 481743020074 ribonuclease P; Reviewed; Region: rnpA; PRK00499 481743020075 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 481743020076 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 481743020077 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 481743020078 Transcriptional regulators [Transcription]; Region: GntR; COG1802 481743020079 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481743020080 DNA-binding site [nucleotide binding]; DNA binding site 481743020081 FCD domain; Region: FCD; pfam07729 481743020082 GntP family permease; Region: GntP_permease; pfam02447 481743020083 fructuronate transporter; Provisional; Region: PRK10034; cl15264 481743020084 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 481743020085 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 481743020086 N- and C-terminal domain interface [polypeptide binding]; other site 481743020087 active site 481743020088 catalytic site [active] 481743020089 metal binding site [ion binding]; metal-binding site 481743020090 carbohydrate binding site [chemical binding]; other site 481743020091 ATP binding site [chemical binding]; other site