-- dump date 20140619_225157 -- class Genbank::misc_feature -- table misc_feature_note -- id note 697284000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 697284000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 697284000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697284000004 Walker A motif; other site 697284000005 ATP binding site [chemical binding]; other site 697284000006 Walker B motif; other site 697284000007 arginine finger; other site 697284000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 697284000009 DnaA box-binding interface [nucleotide binding]; other site 697284000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 697284000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 697284000012 putative DNA binding surface [nucleotide binding]; other site 697284000013 dimer interface [polypeptide binding]; other site 697284000014 beta-clamp/clamp loader binding surface; other site 697284000015 beta-clamp/translesion DNA polymerase binding surface; other site 697284000016 S4 domain; Region: S4_2; pfam13275 697284000017 recombination protein F; Reviewed; Region: recF; PRK00064 697284000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 697284000019 Walker A/P-loop; other site 697284000020 ATP binding site [chemical binding]; other site 697284000021 Q-loop/lid; other site 697284000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284000023 ABC transporter signature motif; other site 697284000024 Walker B; other site 697284000025 D-loop; other site 697284000026 H-loop/switch region; other site 697284000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 697284000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284000029 Mg2+ binding site [ion binding]; other site 697284000030 G-X-G motif; other site 697284000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 697284000032 anchoring element; other site 697284000033 dimer interface [polypeptide binding]; other site 697284000034 ATP binding site [chemical binding]; other site 697284000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 697284000036 active site 697284000037 putative metal-binding site [ion binding]; other site 697284000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 697284000039 DNA gyrase subunit A; Validated; Region: PRK05560 697284000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 697284000041 CAP-like domain; other site 697284000042 active site 697284000043 primary dimer interface [polypeptide binding]; other site 697284000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697284000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697284000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697284000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697284000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697284000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697284000050 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 697284000051 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 697284000052 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 697284000053 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 697284000054 active site 697284000055 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 697284000056 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 697284000057 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 697284000058 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 697284000059 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 697284000060 active site 697284000061 multimer interface [polypeptide binding]; other site 697284000062 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 697284000063 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 697284000064 predicted active site [active] 697284000065 catalytic triad [active] 697284000066 seryl-tRNA synthetase; Provisional; Region: PRK05431 697284000067 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 697284000068 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 697284000069 dimer interface [polypeptide binding]; other site 697284000070 active site 697284000071 motif 1; other site 697284000072 motif 2; other site 697284000073 motif 3; other site 697284000074 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697284000075 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 697284000076 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697284000077 DNA binding residues [nucleotide binding] 697284000078 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 697284000079 nudix motif; other site 697284000080 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 697284000081 nucleoside/Zn binding site; other site 697284000082 dimer interface [polypeptide binding]; other site 697284000083 catalytic motif [active] 697284000084 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284000085 MULE transposase domain; Region: MULE; pfam10551 697284000086 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284000087 MULE transposase domain; Region: MULE; pfam10551 697284000088 GTP-binding protein YchF; Reviewed; Region: PRK09601 697284000089 YchF GTPase; Region: YchF; cd01900 697284000090 G1 box; other site 697284000091 GTP/Mg2+ binding site [chemical binding]; other site 697284000092 Switch I region; other site 697284000093 G2 box; other site 697284000094 Switch II region; other site 697284000095 G3 box; other site 697284000096 G4 box; other site 697284000097 G5 box; other site 697284000098 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 697284000099 peptide chain release factor 1; Validated; Region: prfA; PRK00591 697284000100 This domain is found in peptide chain release factors; Region: PCRF; smart00937 697284000101 RF-1 domain; Region: RF-1; pfam00472 697284000102 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 697284000103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284000104 S-adenosylmethionine binding site [chemical binding]; other site 697284000105 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 697284000106 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 697284000107 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 697284000108 Predicted membrane protein [Function unknown]; Region: COG1971 697284000109 Domain of unknown function DUF; Region: DUF204; pfam02659 697284000110 Domain of unknown function DUF; Region: DUF204; pfam02659 697284000111 Low molecular weight phosphatase family; Region: LMWPc; cd00115 697284000112 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 697284000113 active site 697284000114 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 697284000115 hypothetical protein; Provisional; Region: PRK13690 697284000116 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 697284000117 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 697284000118 dimer interface [polypeptide binding]; other site 697284000119 active site 697284000120 glycine-pyridoxal phosphate binding site [chemical binding]; other site 697284000121 folate binding site [chemical binding]; other site 697284000122 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697284000123 active site 697284000124 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 697284000125 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 697284000126 active site 697284000127 homodimer interface [polypeptide binding]; other site 697284000128 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 697284000129 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 697284000130 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 697284000131 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 697284000132 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 697284000133 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 697284000134 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 697284000135 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 697284000136 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 697284000137 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 697284000138 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 697284000139 beta subunit interaction interface [polypeptide binding]; other site 697284000140 Walker A motif; other site 697284000141 ATP binding site [chemical binding]; other site 697284000142 Walker B motif; other site 697284000143 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 697284000144 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 697284000145 core domain interface [polypeptide binding]; other site 697284000146 delta subunit interface [polypeptide binding]; other site 697284000147 epsilon subunit interface [polypeptide binding]; other site 697284000148 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 697284000149 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 697284000150 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 697284000151 alpha subunit interaction interface [polypeptide binding]; other site 697284000152 Walker A motif; other site 697284000153 ATP binding site [chemical binding]; other site 697284000154 Walker B motif; other site 697284000155 inhibitor binding site; inhibition site 697284000156 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 697284000157 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 697284000158 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 697284000159 gamma subunit interface [polypeptide binding]; other site 697284000160 epsilon subunit interface [polypeptide binding]; other site 697284000161 LBP interface [polypeptide binding]; other site 697284000162 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697284000163 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 697284000164 NADH dehydrogenase subunit A; Validated; Region: PRK07756 697284000165 NADH dehydrogenase subunit B; Validated; Region: PRK06411 697284000166 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 697284000167 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 697284000168 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 697284000169 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 697284000170 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 697284000171 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 697284000172 4Fe-4S binding domain; Region: Fer4; pfam00037 697284000173 4Fe-4S binding domain; Region: Fer4; cl02805 697284000174 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 697284000175 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 697284000176 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 697284000177 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 697284000178 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 697284000179 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 697284000180 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 697284000181 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 697284000182 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00144 697284000183 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 697284000184 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 697284000185 active site 697284000186 catalytic triad [active] 697284000187 S-layer homology domain; Region: SLH; pfam00395 697284000188 S-layer homology domain; Region: SLH; pfam00395 697284000189 S-layer homology domain; Region: SLH; pfam00395 697284000190 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 697284000191 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 697284000192 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 697284000193 hinge; other site 697284000194 active site 697284000195 Stage II sporulation protein; Region: SpoIID; pfam08486 697284000196 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 697284000197 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 697284000198 Peptidase family M23; Region: Peptidase_M23; pfam01551 697284000199 Stage III sporulation protein D; Region: SpoIIID; pfam12116 697284000200 rod shape-determining protein Mbl; Provisional; Region: PRK13928 697284000201 MreB and similar proteins; Region: MreB_like; cd10225 697284000202 nucleotide binding site [chemical binding]; other site 697284000203 Mg binding site [ion binding]; other site 697284000204 putative protofilament interaction site [polypeptide binding]; other site 697284000205 RodZ interaction site [polypeptide binding]; other site 697284000206 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 697284000207 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 697284000208 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 697284000209 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 697284000210 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 697284000211 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 697284000212 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 697284000213 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 697284000214 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 697284000215 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 697284000216 active site 697284000217 substrate binding site [chemical binding]; other site 697284000218 metal binding site [ion binding]; metal-binding site 697284000219 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 697284000220 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 697284000221 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 697284000222 Mg++ binding site [ion binding]; other site 697284000223 putative catalytic motif [active] 697284000224 substrate binding site [chemical binding]; other site 697284000225 S-layer homology domain; Region: SLH; pfam00395 697284000226 S-layer homology domain; Region: SLH; pfam00395 697284000227 S-layer homology domain; Region: SLH; pfam00395 697284000228 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 697284000229 S-adenosylmethionine synthetase; Validated; Region: PRK05250 697284000230 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 697284000231 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 697284000232 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 697284000233 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 697284000234 Sensor protein DegS; Region: DegS; pfam05384 697284000235 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 697284000236 Histidine kinase; Region: HisKA_3; pfam07730 697284000237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284000238 ATP binding site [chemical binding]; other site 697284000239 Mg2+ binding site [ion binding]; other site 697284000240 G-X-G motif; other site 697284000241 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 697284000242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284000243 active site 697284000244 phosphorylation site [posttranslational modification] 697284000245 intermolecular recognition site; other site 697284000246 dimerization interface [polypeptide binding]; other site 697284000247 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 697284000248 DNA binding residues [nucleotide binding] 697284000249 dimerization interface [polypeptide binding]; other site 697284000250 phosphoenolpyruvate carboxylase, archaeal type; Region: PEPCase_arch; TIGR02751 697284000251 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 697284000252 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697284000253 ATP binding site [chemical binding]; other site 697284000254 putative Mg++ binding site [ion binding]; other site 697284000255 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697284000256 ATP-binding site [chemical binding]; other site 697284000257 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 697284000258 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697284000259 active site 697284000260 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 697284000261 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 697284000262 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 697284000263 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 697284000264 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 697284000265 NosL; Region: NosL; cl01769 697284000266 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 697284000267 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 697284000268 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 697284000269 Walker A/P-loop; other site 697284000270 ATP binding site [chemical binding]; other site 697284000271 Q-loop/lid; other site 697284000272 ABC transporter signature motif; other site 697284000273 Walker B; other site 697284000274 D-loop; other site 697284000275 H-loop/switch region; other site 697284000276 YtkA-like; Region: YtkA; pfam13115 697284000277 flagellar operon protein TIGR03826; Region: YvyF 697284000278 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 697284000279 FlgN protein; Region: FlgN; pfam05130 697284000280 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 697284000281 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 697284000282 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 697284000283 flagellar assembly protein FliW; Provisional; Region: PRK13285 697284000284 carbon storage regulator; Provisional; Region: PRK01712 697284000285 flagellin; Provisional; Region: PRK12804 697284000286 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 697284000287 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 697284000288 flagellar capping protein; Validated; Region: fliD; PRK07737 697284000289 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 697284000290 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 697284000291 Flagellar protein FliS; Region: FliS; cl00654 697284000292 Flagellar protein FliT; Region: FliT; pfam05400 697284000293 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 697284000294 DNA-binding site [nucleotide binding]; DNA binding site 697284000295 RNA-binding motif; other site 697284000296 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 697284000297 30S subunit binding site; other site 697284000298 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284000299 MULE transposase domain; Region: MULE; pfam10551 697284000300 S-layer homology domain; Region: SLH; pfam00395 697284000301 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 697284000302 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 697284000303 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 697284000304 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 697284000305 nucleotide binding region [chemical binding]; other site 697284000306 ATP-binding site [chemical binding]; other site 697284000307 SEC-C motif; Region: SEC-C; pfam02810 697284000308 peptide chain release factor 2; Provisional; Region: PRK06746 697284000309 This domain is found in peptide chain release factors; Region: PCRF; smart00937 697284000310 RF-1 domain; Region: RF-1; pfam00472 697284000311 Uncharacterized conserved protein [Function unknown]; Region: COG1284 697284000312 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 697284000313 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 697284000314 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 697284000315 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 697284000316 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 697284000317 heterotetramer interface [polypeptide binding]; other site 697284000318 active site pocket [active] 697284000319 cleavage site 697284000320 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 697284000321 nucleotide binding site [chemical binding]; other site 697284000322 N-acetyl-L-glutamate binding site [chemical binding]; other site 697284000323 acetylornithine aminotransferase; Provisional; Region: PRK02627 697284000324 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 697284000325 inhibitor-cofactor binding pocket; inhibition site 697284000326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284000327 catalytic residue [active] 697284000328 ornithine carbamoyltransferase; Provisional; Region: PRK00779 697284000329 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 697284000330 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 697284000331 argininosuccinate synthase; Provisional; Region: PRK13820 697284000332 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 697284000333 ANP binding site [chemical binding]; other site 697284000334 Substrate Binding Site II [chemical binding]; other site 697284000335 Substrate Binding Site I [chemical binding]; other site 697284000336 argininosuccinate lyase; Provisional; Region: PRK00855 697284000337 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 697284000338 active sites [active] 697284000339 tetramer interface [polypeptide binding]; other site 697284000340 VanW like protein; Region: VanW; pfam04294 697284000341 G5 domain; Region: G5; pfam07501 697284000342 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 697284000343 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 697284000344 Walker A/P-loop; other site 697284000345 ATP binding site [chemical binding]; other site 697284000346 Q-loop/lid; other site 697284000347 ABC transporter signature motif; other site 697284000348 Walker B; other site 697284000349 D-loop; other site 697284000350 H-loop/switch region; other site 697284000351 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 697284000352 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 697284000353 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 697284000354 Peptidase family M23; Region: Peptidase_M23; pfam01551 697284000355 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 697284000356 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 697284000357 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 697284000358 protein binding site [polypeptide binding]; other site 697284000359 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 697284000360 Catalytic dyad [active] 697284000361 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 697284000362 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 697284000363 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 697284000364 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 697284000365 ligand binding site [chemical binding]; other site 697284000366 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 697284000367 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 697284000368 excinuclease ABC subunit B; Provisional; Region: PRK05298 697284000369 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697284000370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697284000371 nucleotide binding region [chemical binding]; other site 697284000372 ATP-binding site [chemical binding]; other site 697284000373 Ultra-violet resistance protein B; Region: UvrB; pfam12344 697284000374 UvrB/uvrC motif; Region: UVR; pfam02151 697284000375 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 697284000376 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 697284000377 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 697284000378 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 697284000379 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 697284000380 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 697284000381 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 697284000382 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 697284000383 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 697284000384 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 697284000385 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284000386 MULE transposase domain; Region: MULE; pfam10551 697284000387 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 697284000388 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 697284000389 GDP-binding site [chemical binding]; other site 697284000390 ACT binding site; other site 697284000391 IMP binding site; other site 697284000392 replicative DNA helicase; Provisional; Region: PRK05748 697284000393 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 697284000394 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 697284000395 Walker A motif; other site 697284000396 ATP binding site [chemical binding]; other site 697284000397 Walker B motif; other site 697284000398 DNA binding loops [nucleotide binding] 697284000399 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 697284000400 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 697284000401 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 697284000402 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 697284000403 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 697284000404 DHH family; Region: DHH; pfam01368 697284000405 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 697284000406 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284000407 MULE transposase domain; Region: MULE; pfam10551 697284000408 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 697284000409 G5 domain; Region: G5; pfam07501 697284000410 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 697284000411 Peptidase family M23; Region: Peptidase_M23; pfam01551 697284000412 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697284000413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284000414 active site 697284000415 phosphorylation site [posttranslational modification] 697284000416 intermolecular recognition site; other site 697284000417 dimerization interface [polypeptide binding]; other site 697284000418 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697284000419 DNA binding site [nucleotide binding] 697284000420 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 697284000421 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697284000422 dimerization interface [polypeptide binding]; other site 697284000423 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 697284000424 putative active site [active] 697284000425 heme pocket [chemical binding]; other site 697284000426 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697284000427 dimer interface [polypeptide binding]; other site 697284000428 phosphorylation site [posttranslational modification] 697284000429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284000430 ATP binding site [chemical binding]; other site 697284000431 Mg2+ binding site [ion binding]; other site 697284000432 G-X-G motif; other site 697284000433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 697284000434 YycH protein; Region: YycH; pfam07435 697284000435 YycH protein; Region: YycI; cl02015 697284000436 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 697284000437 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 697284000438 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 697284000439 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 697284000440 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 697284000441 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 697284000442 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697284000443 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697284000444 DNA binding site [nucleotide binding] 697284000445 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 697284000446 ligand binding site [chemical binding]; other site 697284000447 dimerization interface [polypeptide binding]; other site 697284000448 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 697284000449 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 697284000450 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 697284000451 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 697284000452 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 697284000453 Int/Topo IB signature motif; other site 697284000454 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284000455 MULE transposase domain; Region: MULE; pfam10551 697284000456 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 697284000457 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 697284000458 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 697284000459 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 697284000460 antiholin-like protein LrgB; Provisional; Region: PRK04288 697284000461 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 697284000462 two-component response regulator; Provisional; Region: PRK14084 697284000463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284000464 active site 697284000465 phosphorylation site [posttranslational modification] 697284000466 intermolecular recognition site; other site 697284000467 dimerization interface [polypeptide binding]; other site 697284000468 LytTr DNA-binding domain; Region: LytTR; pfam04397 697284000469 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 697284000470 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 697284000471 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 697284000472 Histidine kinase; Region: His_kinase; pfam06580 697284000473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284000474 ATP binding site [chemical binding]; other site 697284000475 Mg2+ binding site [ion binding]; other site 697284000476 G-X-G motif; other site 697284000477 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 697284000478 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697284000479 Coenzyme A binding pocket [chemical binding]; other site 697284000480 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12858 697284000481 Predicted membrane protein [Function unknown]; Region: COG2510 697284000482 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 697284000483 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 697284000484 active site 697284000485 catalytic tetrad [active] 697284000486 peptidase T; Region: peptidase-T; TIGR01882 697284000487 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 697284000488 metal binding site [ion binding]; metal-binding site 697284000489 dimer interface [polypeptide binding]; other site 697284000490 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 697284000491 Methyltransferase domain; Region: Methyltransf_23; pfam13489 697284000492 Methyltransferase domain; Region: Methyltransf_12; pfam08242 697284000493 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 697284000494 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 697284000495 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 697284000496 extended (e) SDRs; Region: SDR_e; cd08946 697284000497 NAD(P) binding site [chemical binding]; other site 697284000498 substrate binding site [chemical binding]; other site 697284000499 active site 697284000500 Cephalosporin hydroxylase; Region: CmcI; pfam04989 697284000501 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 697284000502 active site 697284000503 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 697284000504 active site 697284000505 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 697284000506 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 697284000507 substrate binding site; other site 697284000508 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 697284000509 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 697284000510 NAD binding site [chemical binding]; other site 697284000511 homotetramer interface [polypeptide binding]; other site 697284000512 homodimer interface [polypeptide binding]; other site 697284000513 substrate binding site [chemical binding]; other site 697284000514 active site 697284000515 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 697284000516 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 697284000517 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 697284000518 Methyltransferase domain; Region: Methyltransf_31; pfam13847 697284000519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284000520 S-adenosylmethionine binding site [chemical binding]; other site 697284000521 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 697284000522 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 697284000523 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 697284000524 NAD(P) binding site [chemical binding]; other site 697284000525 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 697284000526 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 697284000527 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 697284000528 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 697284000529 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 697284000530 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 697284000531 trimer interface [polypeptide binding]; other site 697284000532 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 697284000533 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 697284000534 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 697284000535 active site 697284000536 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 697284000537 active site 697284000538 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 697284000539 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697284000540 catalytic residue [active] 697284000541 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284000542 MULE transposase domain; Region: MULE; pfam10551 697284000543 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 697284000544 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 697284000545 Walker A/P-loop; other site 697284000546 ATP binding site [chemical binding]; other site 697284000547 Q-loop/lid; other site 697284000548 ABC transporter signature motif; other site 697284000549 Walker B; other site 697284000550 D-loop; other site 697284000551 H-loop/switch region; other site 697284000552 PcrB family; Region: PcrB; pfam01884 697284000553 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 697284000554 substrate binding site [chemical binding]; other site 697284000555 putative active site [active] 697284000556 dimer interface [polypeptide binding]; other site 697284000557 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 697284000558 Part of AAA domain; Region: AAA_19; pfam13245 697284000559 Family description; Region: UvrD_C_2; pfam13538 697284000560 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 697284000561 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 697284000562 nucleotide binding pocket [chemical binding]; other site 697284000563 K-X-D-G motif; other site 697284000564 catalytic site [active] 697284000565 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 697284000566 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 697284000567 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 697284000568 Dimer interface [polypeptide binding]; other site 697284000569 Domain of unknown function DUF77; Region: DUF77; pfam01910 697284000570 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 697284000571 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 697284000572 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 697284000573 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 697284000574 Mg++ binding site [ion binding]; other site 697284000575 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 697284000576 putative catalytic motif [active] 697284000577 substrate binding site [chemical binding]; other site 697284000578 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 697284000579 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 697284000580 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 697284000581 Walker A/P-loop; other site 697284000582 ATP binding site [chemical binding]; other site 697284000583 Q-loop/lid; other site 697284000584 ABC transporter signature motif; other site 697284000585 Walker B; other site 697284000586 D-loop; other site 697284000587 H-loop/switch region; other site 697284000588 TOBE domain; Region: TOBE; pfam03459 697284000589 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284000590 MULE transposase domain; Region: MULE; pfam10551 697284000591 HPr kinase/phosphorylase; Provisional; Region: PRK05428 697284000592 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 697284000593 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 697284000594 Hpr binding site; other site 697284000595 active site 697284000596 homohexamer subunit interaction site [polypeptide binding]; other site 697284000597 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 697284000598 pyrophosphatase PpaX; Provisional; Region: PRK13288 697284000599 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697284000600 motif II; other site 697284000601 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 697284000602 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 697284000603 dimer interface [polypeptide binding]; other site 697284000604 motif 1; other site 697284000605 active site 697284000606 motif 2; other site 697284000607 motif 3; other site 697284000608 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 697284000609 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 697284000610 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 697284000611 histidinol dehydrogenase; Region: hisD; TIGR00069 697284000612 NAD binding site [chemical binding]; other site 697284000613 dimerization interface [polypeptide binding]; other site 697284000614 product binding site; other site 697284000615 substrate binding site [chemical binding]; other site 697284000616 zinc binding site [ion binding]; other site 697284000617 catalytic residues [active] 697284000618 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 697284000619 putative active site pocket [active] 697284000620 4-fold oligomerization interface [polypeptide binding]; other site 697284000621 metal binding residues [ion binding]; metal-binding site 697284000622 3-fold/trimer interface [polypeptide binding]; other site 697284000623 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 697284000624 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 697284000625 putative active site [active] 697284000626 oxyanion strand; other site 697284000627 catalytic triad [active] 697284000628 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 697284000629 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 697284000630 catalytic residues [active] 697284000631 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 697284000632 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 697284000633 substrate binding site [chemical binding]; other site 697284000634 glutamase interaction surface [polypeptide binding]; other site 697284000635 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 697284000636 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 697284000637 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 697284000638 metal binding site [ion binding]; metal-binding site 697284000639 histidinol-phosphatase; Provisional; Region: PRK07328 697284000640 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 697284000641 active site 697284000642 dimer interface [polypeptide binding]; other site 697284000643 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 697284000644 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 697284000645 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697284000646 active site 697284000647 TPR repeat; Region: TPR_11; pfam13414 697284000648 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 697284000649 TPR motif; other site 697284000650 Tetratricopeptide repeat; Region: TPR_12; pfam13424 697284000651 binding surface 697284000652 Tetratricopeptide repeat; Region: TPR_16; pfam13432 697284000653 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 697284000654 TPR motif; other site 697284000655 binding surface 697284000656 HEAT repeats; Region: HEAT_2; pfam13646 697284000657 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 697284000658 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 697284000659 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 697284000660 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 697284000661 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 697284000662 nucleotide binding site [chemical binding]; other site 697284000663 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 697284000664 shikimate kinase; Reviewed; Region: aroK; PRK00131 697284000665 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 697284000666 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 697284000667 phosphate binding site [ion binding]; other site 697284000668 putative substrate binding pocket [chemical binding]; other site 697284000669 dimer interface [polypeptide binding]; other site 697284000670 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 697284000671 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 697284000672 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 697284000673 regulatory protein interface [polypeptide binding]; other site 697284000674 active site 697284000675 regulatory phosphorylation site [posttranslational modification]; other site 697284000676 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 697284000677 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 697284000678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284000679 Walker A/P-loop; other site 697284000680 ATP binding site [chemical binding]; other site 697284000681 Q-loop/lid; other site 697284000682 ABC transporter signature motif; other site 697284000683 Walker B; other site 697284000684 D-loop; other site 697284000685 H-loop/switch region; other site 697284000686 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284000687 MULE transposase domain; Region: MULE; pfam10551 697284000688 Clp protease; Region: CLP_protease; pfam00574 697284000689 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 697284000690 oligomer interface [polypeptide binding]; other site 697284000691 active site residues [active] 697284000692 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 697284000693 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 697284000694 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 697284000695 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 697284000696 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 697284000697 Phosphoglycerate kinase; Region: PGK; pfam00162 697284000698 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 697284000699 substrate binding site [chemical binding]; other site 697284000700 hinge regions; other site 697284000701 ADP binding site [chemical binding]; other site 697284000702 catalytic site [active] 697284000703 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 697284000704 triosephosphate isomerase; Provisional; Region: PRK14565 697284000705 substrate binding site [chemical binding]; other site 697284000706 dimer interface [polypeptide binding]; other site 697284000707 catalytic triad [active] 697284000708 phosphoglyceromutase; Provisional; Region: PRK05434 697284000709 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 697284000710 enolase; Provisional; Region: eno; PRK00077 697284000711 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 697284000712 dimer interface [polypeptide binding]; other site 697284000713 metal binding site [ion binding]; metal-binding site 697284000714 substrate binding pocket [chemical binding]; other site 697284000715 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 697284000716 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 697284000717 ribonuclease R; Region: RNase_R; TIGR02063 697284000718 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 697284000719 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 697284000720 RNB domain; Region: RNB; pfam00773 697284000721 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 697284000722 RNA binding site [nucleotide binding]; other site 697284000723 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 697284000724 SmpB-tmRNA interface; other site 697284000725 Recombinase; Region: Recombinase; pfam07508 697284000726 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284000727 MULE transposase domain; Region: MULE; pfam10551 697284000728 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 697284000729 nucleic acid binding site [nucleotide binding]; other site 697284000730 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 697284000731 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 697284000732 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 697284000733 putative metal binding site [ion binding]; other site 697284000734 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 697284000735 active site 697284000736 metal binding site [ion binding]; metal-binding site 697284000737 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 697284000738 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 697284000739 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 697284000740 putative active site [active] 697284000741 catalytic site [active] 697284000742 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 697284000743 putative active site [active] 697284000744 catalytic site [active] 697284000745 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284000746 MULE transposase domain; Region: MULE; pfam10551 697284000747 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 697284000748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284000749 S-adenosylmethionine binding site [chemical binding]; other site 697284000750 Transglycosylase; Region: Transgly; pfam00912 697284000751 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 697284000752 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 697284000753 Substrate binding site; other site 697284000754 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 697284000755 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 697284000756 NADP-binding site; other site 697284000757 homotetramer interface [polypeptide binding]; other site 697284000758 substrate binding site [chemical binding]; other site 697284000759 homodimer interface [polypeptide binding]; other site 697284000760 active site 697284000761 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 697284000762 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 697284000763 Probable Catalytic site; other site 697284000764 metal-binding site 697284000765 Cold-inducible protein YdjO; Region: YdjO; pfam14169 697284000766 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 697284000767 DNA-binding site [nucleotide binding]; DNA binding site 697284000768 RNA-binding motif; other site 697284000769 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 697284000770 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 697284000771 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 697284000772 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 697284000773 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 697284000774 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 697284000775 NADP binding site [chemical binding]; other site 697284000776 homodimer interface [polypeptide binding]; other site 697284000777 active site 697284000778 xanthine permease; Region: pbuX; TIGR03173 697284000779 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697284000780 active site 697284000781 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 697284000782 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 697284000783 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284000784 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284000785 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284000786 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284000787 MULE transposase domain; Region: MULE; pfam10551 697284000788 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 697284000789 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284000790 Walker A/P-loop; other site 697284000791 ATP binding site [chemical binding]; other site 697284000792 Q-loop/lid; other site 697284000793 ABC transporter signature motif; other site 697284000794 Walker B; other site 697284000795 D-loop; other site 697284000796 H-loop/switch region; other site 697284000797 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284000798 MULE transposase domain; Region: MULE; pfam10551 697284000799 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 697284000800 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 697284000801 DNA binding residues [nucleotide binding] 697284000802 dimerization interface [polypeptide binding]; other site 697284000803 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 697284000804 Part of AAA domain; Region: AAA_19; pfam13245 697284000805 Family description; Region: UvrD_C_2; pfam13538 697284000806 Cold-inducible protein YdjO; Region: YdjO; pfam14169 697284000807 Thiamine pyrophosphokinase; Region: TPK; cd07995 697284000808 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 697284000809 active site 697284000810 dimerization interface [polypeptide binding]; other site 697284000811 thiamine binding site [chemical binding]; other site 697284000812 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 697284000813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697284000814 dimer interface [polypeptide binding]; other site 697284000815 phosphorylation site [posttranslational modification] 697284000816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284000817 ATP binding site [chemical binding]; other site 697284000818 Mg2+ binding site [ion binding]; other site 697284000819 G-X-G motif; other site 697284000820 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697284000821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284000822 active site 697284000823 phosphorylation site [posttranslational modification] 697284000824 intermolecular recognition site; other site 697284000825 dimerization interface [polypeptide binding]; other site 697284000826 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697284000827 DNA binding site [nucleotide binding] 697284000828 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 697284000829 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 697284000830 Protein of unknown function (DUF466); Region: DUF466; pfam04328 697284000831 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 697284000832 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 697284000833 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 697284000834 Soluble P-type ATPase [General function prediction only]; Region: COG4087 697284000835 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 697284000836 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 697284000837 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 697284000838 Ligand Binding Site [chemical binding]; other site 697284000839 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 697284000840 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 697284000841 Ligand Binding Site [chemical binding]; other site 697284000842 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284000843 Q-loop/lid; other site 697284000844 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 697284000845 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 697284000846 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 697284000847 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 697284000848 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 697284000849 thymidine kinase; Provisional; Region: PRK04296 697284000850 Transcriptional regulators [Transcription]; Region: GntR; COG1802 697284000851 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697284000852 DNA-binding site [nucleotide binding]; DNA binding site 697284000853 FCD domain; Region: FCD; pfam07729 697284000854 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 697284000855 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697284000856 motif II; other site 697284000857 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284000858 MULE transposase domain; Region: MULE; pfam10551 697284000859 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 697284000860 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 697284000861 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 697284000862 putative active site [active] 697284000863 catalytic site [active] 697284000864 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 697284000865 putative active site [active] 697284000866 catalytic site [active] 697284000867 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 697284000868 nucleotide binding site [chemical binding]; other site 697284000869 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 697284000870 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 697284000871 active site 697284000872 DNA binding site [nucleotide binding] 697284000873 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 697284000874 DNA binding site [nucleotide binding] 697284000875 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 697284000876 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 697284000877 putative DNA binding site [nucleotide binding]; other site 697284000878 putative homodimer interface [polypeptide binding]; other site 697284000879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284000880 dimer interface [polypeptide binding]; other site 697284000881 conserved gate region; other site 697284000882 putative PBP binding loops; other site 697284000883 ABC-ATPase subunit interface; other site 697284000884 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 697284000885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284000886 dimer interface [polypeptide binding]; other site 697284000887 conserved gate region; other site 697284000888 putative PBP binding loops; other site 697284000889 ABC-ATPase subunit interface; other site 697284000890 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 697284000891 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 697284000892 Walker A/P-loop; other site 697284000893 ATP binding site [chemical binding]; other site 697284000894 Q-loop/lid; other site 697284000895 ABC transporter signature motif; other site 697284000896 Walker B; other site 697284000897 D-loop; other site 697284000898 H-loop/switch region; other site 697284000899 TOBE domain; Region: TOBE; pfam03459 697284000900 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 697284000901 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 697284000902 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 697284000903 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 697284000904 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 697284000905 hydroxyglutarate oxidase; Provisional; Region: PRK11728 697284000906 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 697284000907 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697284000908 Coenzyme A binding pocket [chemical binding]; other site 697284000909 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 697284000910 HTH domain; Region: HTH_11; pfam08279 697284000911 PRD domain; Region: PRD; pfam00874 697284000912 PRD domain; Region: PRD; pfam00874 697284000913 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 697284000914 active site 697284000915 P-loop; other site 697284000916 phosphorylation site [posttranslational modification] 697284000917 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 697284000918 active site 697284000919 phosphorylation site [posttranslational modification] 697284000920 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 697284000921 dimerization domain swap beta strand [polypeptide binding]; other site 697284000922 regulatory protein interface [polypeptide binding]; other site 697284000923 active site 697284000924 regulatory phosphorylation site [posttranslational modification]; other site 697284000925 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 697284000926 active site 697284000927 phosphorylation site [posttranslational modification] 697284000928 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 697284000929 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 697284000930 active site 697284000931 P-loop; other site 697284000932 phosphorylation site [posttranslational modification] 697284000933 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 697284000934 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 697284000935 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 697284000936 Glycoprotease family; Region: Peptidase_M22; pfam00814 697284000937 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 697284000938 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 697284000939 UGMP family protein; Validated; Region: PRK09604 697284000940 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 697284000941 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 697284000942 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 697284000943 putative dimer interface [polypeptide binding]; other site 697284000944 catalytic triad [active] 697284000945 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 697284000946 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697284000947 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697284000948 ABC transporter; Region: ABC_tran_2; pfam12848 697284000949 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697284000950 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 697284000951 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 697284000952 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 697284000953 trimer interface [polypeptide binding]; other site 697284000954 dimer interface [polypeptide binding]; other site 697284000955 putative active site [active] 697284000956 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 697284000957 MPT binding site; other site 697284000958 trimer interface [polypeptide binding]; other site 697284000959 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 697284000960 putative MPT binding site; other site 697284000961 twin arginine translocase protein A; Provisional; Region: tatA; PRK00191 697284000962 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 697284000963 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 697284000964 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 697284000965 oligomerisation interface [polypeptide binding]; other site 697284000966 mobile loop; other site 697284000967 roof hairpin; other site 697284000968 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 697284000969 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 697284000970 ring oligomerisation interface [polypeptide binding]; other site 697284000971 ATP/Mg binding site [chemical binding]; other site 697284000972 stacking interactions; other site 697284000973 hinge regions; other site 697284000974 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 697284000975 DNA binding site [nucleotide binding] 697284000976 Int/Topo IB signature motif; other site 697284000977 active site 697284000978 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284000979 MULE transposase domain; Region: MULE; pfam10551 697284000980 Spore germination protein; Region: Spore_permease; cl17796 697284000981 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 697284000982 Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495 697284000983 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284000984 MULE transposase domain; Region: MULE; pfam10551 697284000985 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 697284000986 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 697284000987 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697284000988 catalytic residue [active] 697284000989 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 697284000990 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 697284000991 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 697284000992 active site 697284000993 HIGH motif; other site 697284000994 dimer interface [polypeptide binding]; other site 697284000995 KMSKS motif; other site 697284000996 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697284000997 RNA binding surface [nucleotide binding]; other site 697284000998 Replication protein; Region: Rep_1; cl02412 697284000999 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001000 MULE transposase domain; Region: MULE; pfam10551 697284001001 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 697284001002 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 697284001003 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697284001004 catalytic residue [active] 697284001005 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 697284001006 dimer interface [polypeptide binding]; other site 697284001007 substrate binding site [chemical binding]; other site 697284001008 ATP binding site [chemical binding]; other site 697284001009 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 697284001010 Trp repressor protein; Region: Trp_repressor; cl17266 697284001011 Uncharacterized conserved protein [Function unknown]; Region: COG0398 697284001012 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 697284001013 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 697284001014 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 697284001015 active site 697284001016 metal binding site [ion binding]; metal-binding site 697284001017 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 697284001018 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 697284001019 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 697284001020 NAD binding site [chemical binding]; other site 697284001021 substrate binding site [chemical binding]; other site 697284001022 homodimer interface [polypeptide binding]; other site 697284001023 active site 697284001024 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 697284001025 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 697284001026 NADP binding site [chemical binding]; other site 697284001027 active site 697284001028 putative substrate binding site [chemical binding]; other site 697284001029 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697284001030 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 697284001031 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697284001032 DNA binding residues [nucleotide binding] 697284001033 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001034 MULE transposase domain; Region: MULE; pfam10551 697284001035 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 697284001036 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001037 MULE transposase domain; Region: MULE; pfam10551 697284001038 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 697284001039 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 697284001040 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 697284001041 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 697284001042 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 697284001043 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 697284001044 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 697284001045 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 697284001046 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 697284001047 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001048 MULE transposase domain; Region: MULE; pfam10551 697284001049 Homeodomain-like domain; Region: HTH_23; pfam13384 697284001050 Winged helix-turn helix; Region: HTH_29; pfam13551 697284001051 Winged helix-turn helix; Region: HTH_33; pfam13592 697284001052 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697284001053 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 697284001054 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 697284001055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284001056 Walker A/P-loop; other site 697284001057 ATP binding site [chemical binding]; other site 697284001058 Q-loop/lid; other site 697284001059 ABC transporter signature motif; other site 697284001060 Walker B; other site 697284001061 D-loop; other site 697284001062 H-loop/switch region; other site 697284001063 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 697284001064 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 697284001065 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001066 MULE transposase domain; Region: MULE; pfam10551 697284001067 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 697284001068 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 697284001069 alanine racemase; Reviewed; Region: alr; PRK00053 697284001070 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 697284001071 active site 697284001072 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 697284001073 dimer interface [polypeptide binding]; other site 697284001074 substrate binding site [chemical binding]; other site 697284001075 catalytic residues [active] 697284001076 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 697284001077 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 697284001078 PemK-like protein; Region: PemK; pfam02452 697284001079 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 697284001080 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 697284001081 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 697284001082 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 697284001083 RNA binding site [nucleotide binding]; other site 697284001084 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 697284001085 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697284001086 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697284001087 DNA binding residues [nucleotide binding] 697284001088 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 697284001089 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 697284001090 active site 697284001091 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 697284001092 hypothetical protein; Provisional; Region: PRK04351 697284001093 SprT homologues; Region: SprT; cl01182 697284001094 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 697284001095 Int/Topo IB signature motif; other site 697284001096 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 697284001097 Catalytic site [active] 697284001098 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001099 MULE transposase domain; Region: MULE; pfam10551 697284001100 D-mannose binding lectin; Region: B_lectin; pfam01453 697284001101 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001102 MULE transposase domain; Region: MULE; pfam10551 697284001103 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 697284001104 HEAT repeats; Region: HEAT_2; pfam13646 697284001105 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 697284001106 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 697284001107 Walker A/P-loop; other site 697284001108 ATP binding site [chemical binding]; other site 697284001109 Q-loop/lid; other site 697284001110 ABC transporter signature motif; other site 697284001111 Walker B; other site 697284001112 D-loop; other site 697284001113 H-loop/switch region; other site 697284001114 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001115 MULE transposase domain; Region: MULE; pfam10551 697284001116 Radical SAM superfamily; Region: Radical_SAM; pfam04055 697284001117 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697284001118 FeS/SAM binding site; other site 697284001119 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 697284001120 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 697284001121 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 697284001122 dimerization interface [polypeptide binding]; other site 697284001123 mannose binding site [chemical binding]; other site 697284001124 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 697284001125 Cache domain; Region: Cache_1; pfam02743 697284001126 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 697284001127 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697284001128 dimerization interface [polypeptide binding]; other site 697284001129 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 697284001130 dimer interface [polypeptide binding]; other site 697284001131 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 697284001132 dimer interface [polypeptide binding]; other site 697284001133 putative CheW interface [polypeptide binding]; other site 697284001134 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001135 MULE transposase domain; Region: MULE; pfam10551 697284001136 Predicted membrane protein [Function unknown]; Region: COG2323 697284001137 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001138 MULE transposase domain; Region: MULE; pfam10551 697284001139 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 697284001140 active site 697284001141 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 697284001142 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697284001143 putative DNA binding site [nucleotide binding]; other site 697284001144 putative Zn2+ binding site [ion binding]; other site 697284001145 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 697284001146 Pex19 protein family; Region: Pex19; pfam04614 697284001147 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 697284001148 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 697284001149 active site 697284001150 catalytic residues [active] 697284001151 metal binding site [ion binding]; metal-binding site 697284001152 methionine sulfoxide reductase A; Provisional; Region: PRK14054 697284001153 methionine sulfoxide reductase B; Provisional; Region: PRK00222 697284001154 SelR domain; Region: SelR; pfam01641 697284001155 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 697284001156 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 697284001157 cyanate transporter; Region: CynX; TIGR00896 697284001158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284001159 putative substrate translocation pore; other site 697284001160 Predicted transcriptional regulator [Transcription]; Region: COG1959 697284001161 Transcriptional regulator; Region: Rrf2; pfam02082 697284001162 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 697284001163 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697284001164 DNA-binding site [nucleotide binding]; DNA binding site 697284001165 UTRA domain; Region: UTRA; pfam07702 697284001166 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 697284001167 active site 697284001168 phosphorylation site [posttranslational modification] 697284001169 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 697284001170 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 697284001171 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 697284001172 active pocket/dimerization site; other site 697284001173 active site 697284001174 phosphorylation site [posttranslational modification] 697284001175 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284001176 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 697284001177 acyl-activating enzyme (AAE) consensus motif; other site 697284001178 AMP binding site [chemical binding]; other site 697284001179 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284001180 thioester reductase domain; Region: Thioester-redct; TIGR01746 697284001181 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 697284001182 putative NAD(P) binding site [chemical binding]; other site 697284001183 active site 697284001184 putative substrate binding site [chemical binding]; other site 697284001185 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697284001186 dimerization interface [polypeptide binding]; other site 697284001187 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 697284001188 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 697284001189 dimer interface [polypeptide binding]; other site 697284001190 putative CheW interface [polypeptide binding]; other site 697284001191 YcxB-like protein; Region: YcxB; pfam14317 697284001192 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 697284001193 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 697284001194 Sterol carrier protein domain; Region: SCP2_2; pfam13530 697284001195 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 697284001196 ApbE family; Region: ApbE; pfam02424 697284001197 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 697284001198 trimer interface [polypeptide binding]; other site 697284001199 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 697284001200 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 697284001201 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 697284001202 Walker A/P-loop; other site 697284001203 ATP binding site [chemical binding]; other site 697284001204 Q-loop/lid; other site 697284001205 ABC transporter signature motif; other site 697284001206 Walker B; other site 697284001207 D-loop; other site 697284001208 H-loop/switch region; other site 697284001209 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 697284001210 ABC transporter; Region: ABC_tran; pfam00005 697284001211 Q-loop/lid; other site 697284001212 ABC transporter signature motif; other site 697284001213 Walker B; other site 697284001214 D-loop; other site 697284001215 H-loop/switch region; other site 697284001216 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 697284001217 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 697284001218 Peptidase family U32; Region: Peptidase_U32; pfam01136 697284001219 Peptidase family U32; Region: Peptidase_U32; cl03113 697284001220 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 697284001221 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 697284001222 inhibitor-cofactor binding pocket; inhibition site 697284001223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284001224 catalytic residue [active] 697284001225 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 697284001226 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 697284001227 UbiA prenyltransferase family; Region: UbiA; pfam01040 697284001228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284001229 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 697284001230 ATP binding site [chemical binding]; other site 697284001231 Mg2+ binding site [ion binding]; other site 697284001232 G-X-G motif; other site 697284001233 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697284001234 dimerization interface [polypeptide binding]; other site 697284001235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284001236 active site 697284001237 phosphorylation site [posttranslational modification] 697284001238 intermolecular recognition site; other site 697284001239 dimerization interface [polypeptide binding]; other site 697284001240 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001241 MULE transposase domain; Region: MULE; pfam10551 697284001242 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697284001243 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 697284001244 Walker A/P-loop; other site 697284001245 ATP binding site [chemical binding]; other site 697284001246 Q-loop/lid; other site 697284001247 ABC transporter signature motif; other site 697284001248 Walker B; other site 697284001249 D-loop; other site 697284001250 H-loop/switch region; other site 697284001251 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001252 MULE transposase domain; Region: MULE; pfam10551 697284001253 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 697284001254 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 697284001255 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 697284001256 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 697284001257 catalytic triad [active] 697284001258 catalytic triad [active] 697284001259 oxyanion hole [active] 697284001260 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284001261 Transposase; Region: HTH_Tnp_1; cl17663 697284001262 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284001263 HTH-like domain; Region: HTH_21; pfam13276 697284001264 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 697284001265 Integrase core domain; Region: rve; pfam00665 697284001266 Integrase core domain; Region: rve_2; pfam13333 697284001267 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 697284001268 Beta-lactamase; Region: Beta-lactamase; pfam00144 697284001269 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 697284001270 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 697284001271 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 697284001272 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 697284001273 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 697284001274 TQO small subunit DoxD; Region: DoxD; pfam04173 697284001275 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 697284001276 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 697284001277 substrate binding pocket [chemical binding]; other site 697284001278 chain length determination region; other site 697284001279 substrate-Mg2+ binding site; other site 697284001280 catalytic residues [active] 697284001281 aspartate-rich region 1; other site 697284001282 active site lid residues [active] 697284001283 aspartate-rich region 2; other site 697284001284 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 697284001285 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 697284001286 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 697284001287 helix-hairpin-helix signature motif; other site 697284001288 MULE transposase domain; Region: MULE; pfam10551 697284001289 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001290 MULE transposase domain; Region: MULE; pfam10551 697284001291 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 697284001292 active site 697284001293 conformational flexibility of ligand binding pocket; other site 697284001294 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001295 MULE transposase domain; Region: MULE; pfam10551 697284001296 Transposase; Region: HTH_Tnp_1; cl17663 697284001297 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 697284001298 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 697284001299 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 697284001300 active site 697284001301 HIGH motif; other site 697284001302 KMSK motif region; other site 697284001303 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 697284001304 tRNA binding surface [nucleotide binding]; other site 697284001305 anticodon binding site; other site 697284001306 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 697284001307 Ligand Binding Site [chemical binding]; other site 697284001308 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 697284001309 active site 697284001310 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 697284001311 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697284001312 FeS/SAM binding site; other site 697284001313 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 697284001314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284001315 S-adenosylmethionine binding site [chemical binding]; other site 697284001316 dipeptidase PepV; Reviewed; Region: PRK07318 697284001317 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 697284001318 active site 697284001319 metal binding site [ion binding]; metal-binding site 697284001320 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001321 MULE transposase domain; Region: MULE; pfam10551 697284001322 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 697284001323 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 697284001324 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697284001325 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697284001326 DNA binding residues [nucleotide binding] 697284001327 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 697284001328 Double zinc ribbon; Region: DZR; pfam12773 697284001329 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 697284001330 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 697284001331 thiamine phosphate binding site [chemical binding]; other site 697284001332 active site 697284001333 pyrophosphate binding site [ion binding]; other site 697284001334 FAD dependent oxidoreductase; Region: DAO; pfam01266 697284001335 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 697284001336 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 697284001337 thiS-thiF/thiG interaction site; other site 697284001338 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 697284001339 ThiS interaction site; other site 697284001340 putative active site [active] 697284001341 tetramer interface [polypeptide binding]; other site 697284001342 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 697284001343 dimer interface [polypeptide binding]; other site 697284001344 substrate binding site [chemical binding]; other site 697284001345 ATP binding site [chemical binding]; other site 697284001346 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001347 MULE transposase domain; Region: MULE; pfam10551 697284001348 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 697284001349 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 697284001350 Presynaptic Site I dimer interface [polypeptide binding]; other site 697284001351 catalytic residues [active] 697284001352 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 697284001353 Synaptic Flat tetramer interface [polypeptide binding]; other site 697284001354 Synaptic Site I dimer interface [polypeptide binding]; other site 697284001355 DNA binding site [nucleotide binding] 697284001356 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 697284001357 DNA-binding interface [nucleotide binding]; DNA binding site 697284001358 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284001359 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 697284001360 Walker A/P-loop; other site 697284001361 ATP binding site [chemical binding]; other site 697284001362 Q-loop/lid; other site 697284001363 ABC transporter signature motif; other site 697284001364 Walker B; other site 697284001365 D-loop; other site 697284001366 H-loop/switch region; other site 697284001367 HTH-like domain; Region: HTH_21; pfam13276 697284001368 Integrase core domain; Region: rve; pfam00665 697284001369 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284001370 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284001371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 697284001372 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284001373 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 697284001374 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 697284001375 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 697284001376 Virulence factor; Region: Virulence_fact; pfam13769 697284001377 HEAT repeats; Region: HEAT_2; pfam13646 697284001378 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 697284001379 HEAT repeats; Region: HEAT_2; pfam13646 697284001380 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 697284001381 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 697284001382 Guanylate kinase; Region: Guanylate_kin; pfam00625 697284001383 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 697284001384 active site 697284001385 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 697284001386 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 697284001387 Cytochrome c; Region: Cytochrom_C; cl11414 697284001388 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 697284001389 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 697284001390 D-pathway; other site 697284001391 Putative ubiquinol binding site [chemical binding]; other site 697284001392 Low-spin heme (heme b) binding site [chemical binding]; other site 697284001393 Putative water exit pathway; other site 697284001394 Binuclear center (heme o3/CuB) [ion binding]; other site 697284001395 K-pathway; other site 697284001396 Putative proton exit pathway; other site 697284001397 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 697284001398 Subunit I/III interface [polypeptide binding]; other site 697284001399 Subunit III/IV interface [polypeptide binding]; other site 697284001400 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 697284001401 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 697284001402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 697284001403 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 697284001404 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001405 MULE transposase domain; Region: MULE; pfam10551 697284001406 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 697284001407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284001408 Walker A/P-loop; other site 697284001409 ATP binding site [chemical binding]; other site 697284001410 Q-loop/lid; other site 697284001411 ABC transporter signature motif; other site 697284001412 Walker B; other site 697284001413 D-loop; other site 697284001414 H-loop/switch region; other site 697284001415 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 697284001416 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 697284001417 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 697284001418 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 697284001419 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697284001420 catalytic residue [active] 697284001421 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001422 MULE transposase domain; Region: MULE; pfam10551 697284001423 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 697284001424 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 697284001425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284001426 homodimer interface [polypeptide binding]; other site 697284001427 catalytic residue [active] 697284001428 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 697284001429 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 697284001430 NodB motif; other site 697284001431 active site 697284001432 catalytic site [active] 697284001433 metal binding site [ion binding]; metal-binding site 697284001434 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 697284001435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284001436 salt bridge; other site 697284001437 non-specific DNA binding site [nucleotide binding]; other site 697284001438 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697284001439 sequence-specific DNA binding site [nucleotide binding]; other site 697284001440 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 697284001441 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 697284001442 dimer interface [polypeptide binding]; other site 697284001443 active site 697284001444 maltose O-acetyltransferase; Provisional; Region: PRK10092 697284001445 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 697284001446 active site 697284001447 substrate binding site [chemical binding]; other site 697284001448 trimer interface [polypeptide binding]; other site 697284001449 CoA binding site [chemical binding]; other site 697284001450 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697284001451 putative DNA binding site [nucleotide binding]; other site 697284001452 putative Zn2+ binding site [ion binding]; other site 697284001453 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001454 MULE transposase domain; Region: MULE; pfam10551 697284001455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697284001456 Coenzyme A binding pocket [chemical binding]; other site 697284001457 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 697284001458 putative inner membrane protein; Provisional; Region: PRK11099 697284001459 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001460 MULE transposase domain; Region: MULE; pfam10551 697284001461 hypothetical protein; Provisional; Region: PRK14082 697284001462 Holin family; Region: Phage_holin_4; cl01989 697284001463 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 697284001464 putative hydrophobic ligand binding site [chemical binding]; other site 697284001465 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697284001466 dimerization interface [polypeptide binding]; other site 697284001467 putative DNA binding site [nucleotide binding]; other site 697284001468 putative Zn2+ binding site [ion binding]; other site 697284001469 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 697284001470 DNA binding site [nucleotide binding] 697284001471 active site 697284001472 putative oxidoreductase; Provisional; Region: PRK11579 697284001473 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 697284001474 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 697284001475 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 697284001476 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 697284001477 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 697284001478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 697284001479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 697284001480 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 697284001481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284001482 H+ Antiporter protein; Region: 2A0121; TIGR00900 697284001483 putative substrate translocation pore; other site 697284001484 Phosphotransferase enzyme family; Region: APH; pfam01636 697284001485 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 697284001486 active site 697284001487 ATP binding site [chemical binding]; other site 697284001488 substrate binding site [chemical binding]; other site 697284001489 EamA-like transporter family; Region: EamA; cl17759 697284001490 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 697284001491 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 697284001492 active site 697284001493 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 697284001494 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 697284001495 active site 697284001496 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 697284001497 NlpC/P60 family; Region: NLPC_P60; pfam00877 697284001498 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 697284001499 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697284001500 dimerization interface [polypeptide binding]; other site 697284001501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697284001502 dimer interface [polypeptide binding]; other site 697284001503 phosphorylation site [posttranslational modification] 697284001504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284001505 ATP binding site [chemical binding]; other site 697284001506 Mg2+ binding site [ion binding]; other site 697284001507 G-X-G motif; other site 697284001508 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697284001509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284001510 active site 697284001511 phosphorylation site [posttranslational modification] 697284001512 intermolecular recognition site; other site 697284001513 dimerization interface [polypeptide binding]; other site 697284001514 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697284001515 DNA binding site [nucleotide binding] 697284001516 HTH-like domain; Region: HTH_21; pfam13276 697284001517 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 697284001518 Integrase core domain; Region: rve; pfam00665 697284001519 Integrase core domain; Region: rve_2; pfam13333 697284001520 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284001521 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284001522 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284001523 Transposase; Region: HTH_Tnp_1; cl17663 697284001524 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284001525 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 697284001526 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 697284001527 active site 697284001528 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 697284001529 Walker A/P-loop; other site 697284001530 ATP binding site [chemical binding]; other site 697284001531 ABC transporter; Region: ABC_tran; pfam00005 697284001532 Q-loop/lid; other site 697284001533 ABC transporter signature motif; other site 697284001534 Walker B; other site 697284001535 D-loop; other site 697284001536 H-loop/switch region; other site 697284001537 Transposase IS200 like; Region: Y1_Tnp; pfam01797 697284001538 Probable transposase; Region: OrfB_IS605; pfam01385 697284001539 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 697284001540 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 697284001541 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 697284001542 HI0933-like protein; Region: HI0933_like; pfam03486 697284001543 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 697284001544 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 697284001545 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 697284001546 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 697284001547 active site 697284001548 metal binding site [ion binding]; metal-binding site 697284001549 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 697284001550 Short C-terminal domain; Region: SHOCT; pfam09851 697284001551 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 697284001552 PspC domain; Region: PspC; pfam04024 697284001553 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 697284001554 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 697284001555 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 697284001556 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 697284001557 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 697284001558 homodimer interface [polypeptide binding]; other site 697284001559 NAD binding pocket [chemical binding]; other site 697284001560 ATP binding pocket [chemical binding]; other site 697284001561 Mg binding site [ion binding]; other site 697284001562 active-site loop [active] 697284001563 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 697284001564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284001565 Walker A/P-loop; other site 697284001566 ATP binding site [chemical binding]; other site 697284001567 Q-loop/lid; other site 697284001568 ABC transporter signature motif; other site 697284001569 Walker B; other site 697284001570 D-loop; other site 697284001571 H-loop/switch region; other site 697284001572 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 697284001573 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 697284001574 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 697284001575 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001576 MULE transposase domain; Region: MULE; pfam10551 697284001577 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 697284001578 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 697284001579 dimer interface [polypeptide binding]; other site 697284001580 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 697284001581 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 697284001582 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 697284001583 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 697284001584 putative active site [active] 697284001585 heme pocket [chemical binding]; other site 697284001586 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 697284001587 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 697284001588 putative active site [active] 697284001589 heme pocket [chemical binding]; other site 697284001590 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697284001591 dimer interface [polypeptide binding]; other site 697284001592 phosphorylation site [posttranslational modification] 697284001593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284001594 ATP binding site [chemical binding]; other site 697284001595 Mg2+ binding site [ion binding]; other site 697284001596 G-X-G motif; other site 697284001597 Uncharacterized conserved protein [Function unknown]; Region: COG3377 697284001598 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 697284001599 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697284001600 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 697284001601 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 697284001602 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 697284001603 Phosphotransferase enzyme family; Region: APH; pfam01636 697284001604 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 697284001605 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 697284001606 dimerization interface [polypeptide binding]; other site 697284001607 DPS ferroxidase diiron center [ion binding]; other site 697284001608 ion pore; other site 697284001609 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001610 MULE transposase domain; Region: MULE; pfam10551 697284001611 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 697284001612 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 697284001613 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 697284001614 Walker A/P-loop; other site 697284001615 ATP binding site [chemical binding]; other site 697284001616 Q-loop/lid; other site 697284001617 ABC transporter signature motif; other site 697284001618 Walker B; other site 697284001619 D-loop; other site 697284001620 H-loop/switch region; other site 697284001621 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 697284001622 FeS assembly protein SufD; Region: sufD; TIGR01981 697284001623 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 697284001624 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 697284001625 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697284001626 catalytic residue [active] 697284001627 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 697284001628 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 697284001629 trimerization site [polypeptide binding]; other site 697284001630 active site 697284001631 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 697284001632 FeS assembly protein SufB; Region: sufB; TIGR01980 697284001633 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 697284001634 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001635 MULE transposase domain; Region: MULE; pfam10551 697284001636 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 697284001637 Kelch domain; Region: Kelch; smart00612 697284001638 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 697284001639 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 697284001640 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 697284001641 amidase catalytic site [active] 697284001642 Zn binding residues [ion binding]; other site 697284001643 substrate binding site [chemical binding]; other site 697284001644 HTH-like domain; Region: HTH_21; pfam13276 697284001645 Integrase core domain; Region: rve; pfam00665 697284001646 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 697284001647 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001648 MULE transposase domain; Region: MULE; pfam10551 697284001649 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 697284001650 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001651 MULE transposase domain; Region: MULE; pfam10551 697284001652 Transposase; Region: HTH_Tnp_1; cl17663 697284001653 putative transposase OrfB; Reviewed; Region: PHA02517 697284001654 HTH-like domain; Region: HTH_21; pfam13276 697284001655 Integrase core domain; Region: rve; pfam00665 697284001656 Integrase core domain; Region: rve_3; pfam13683 697284001657 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 697284001658 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001659 MULE transposase domain; Region: MULE; pfam10551 697284001660 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 697284001661 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697284001662 Zn2+ binding site [ion binding]; other site 697284001663 Mg2+ binding site [ion binding]; other site 697284001664 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001665 MULE transposase domain; Region: MULE; pfam10551 697284001666 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 697284001667 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 697284001668 active site 697284001669 metal binding site [ion binding]; metal-binding site 697284001670 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 697284001671 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 697284001672 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001673 MULE transposase domain; Region: MULE; pfam10551 697284001674 Radical SAM superfamily; Region: Radical_SAM; pfam04055 697284001675 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697284001676 FeS/SAM binding site; other site 697284001677 YfkB-like domain; Region: YfkB; pfam08756 697284001678 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 697284001679 Domain of unknown function DUF21; Region: DUF21; pfam01595 697284001680 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 697284001681 Transporter associated domain; Region: CorC_HlyC; smart01091 697284001682 HTH-like domain; Region: HTH_21; pfam13276 697284001683 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 697284001684 Integrase core domain; Region: rve; pfam00665 697284001685 Integrase core domain; Region: rve_2; pfam13333 697284001686 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284001687 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284001688 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284001689 Transposase; Region: HTH_Tnp_1; cl17663 697284001690 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284001691 CotJB protein; Region: CotJB; pfam12652 697284001692 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 697284001693 dinuclear metal binding motif [ion binding]; other site 697284001694 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 697284001695 Integrase core domain; Region: rve_3; cl15866 697284001696 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001697 MULE transposase domain; Region: MULE; pfam10551 697284001698 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 697284001699 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 697284001700 Homeodomain-like domain; Region: HTH_23; pfam13384 697284001701 Winged helix-turn helix; Region: HTH_29; pfam13551 697284001702 Winged helix-turn helix; Region: HTH_33; pfam13592 697284001703 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697284001704 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 697284001705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697284001706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697284001707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697284001708 active site 697284001709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697284001710 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 697284001711 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 697284001712 active site 697284001713 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 697284001714 3D domain; Region: 3D; cl01439 697284001715 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 697284001716 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 697284001717 NodB motif; other site 697284001718 active site 697284001719 catalytic site [active] 697284001720 metal binding site [ion binding]; metal-binding site 697284001721 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 697284001722 NlpC/P60 family; Region: NLPC_P60; pfam00877 697284001723 Holin family; Region: Phage_holin_4; pfam05105 697284001724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697284001725 active site 697284001726 Pirin-related protein [General function prediction only]; Region: COG1741 697284001727 Pirin; Region: Pirin; pfam02678 697284001728 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 697284001729 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 697284001730 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 697284001731 active site 697284001732 dimer interface [polypeptide binding]; other site 697284001733 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 697284001734 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 697284001735 active site 697284001736 trimer interface [polypeptide binding]; other site 697284001737 allosteric site; other site 697284001738 active site lid [active] 697284001739 hexamer (dimer of trimers) interface [polypeptide binding]; other site 697284001740 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 697284001741 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 697284001742 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 697284001743 putative active site [active] 697284001744 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 697284001745 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697284001746 motif II; other site 697284001747 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 697284001748 Predicted oxidoreductase [General function prediction only]; Region: COG3573 697284001749 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 697284001750 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 697284001751 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 697284001752 active site 697284001753 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001754 MULE transposase domain; Region: MULE; pfam10551 697284001755 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 697284001756 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 697284001757 minor groove reading motif; other site 697284001758 helix-hairpin-helix signature motif; other site 697284001759 substrate binding pocket [chemical binding]; other site 697284001760 active site 697284001761 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 697284001762 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 697284001763 DNA binding and oxoG recognition site [nucleotide binding] 697284001764 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001765 MULE transposase domain; Region: MULE; pfam10551 697284001766 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001767 MULE transposase domain; Region: MULE; pfam10551 697284001768 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 697284001769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284001770 Walker A/P-loop; other site 697284001771 ATP binding site [chemical binding]; other site 697284001772 Q-loop/lid; other site 697284001773 ABC transporter signature motif; other site 697284001774 Walker B; other site 697284001775 D-loop; other site 697284001776 H-loop/switch region; other site 697284001777 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 697284001778 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 697284001779 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 697284001780 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 697284001781 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 697284001782 DNA binding residues [nucleotide binding] 697284001783 dimerization interface [polypeptide binding]; other site 697284001784 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 697284001785 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 697284001786 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 697284001787 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697284001788 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697284001789 DNA binding site [nucleotide binding] 697284001790 domain linker motif; other site 697284001791 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 697284001792 dimerization interface [polypeptide binding]; other site 697284001793 ligand binding site [chemical binding]; other site 697284001794 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 697284001795 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 697284001796 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 697284001797 NAD binding site [chemical binding]; other site 697284001798 sugar binding site [chemical binding]; other site 697284001799 divalent metal binding site [ion binding]; other site 697284001800 tetramer (dimer of dimers) interface [polypeptide binding]; other site 697284001801 dimer interface [polypeptide binding]; other site 697284001802 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 697284001803 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 697284001804 Walker A/P-loop; other site 697284001805 ATP binding site [chemical binding]; other site 697284001806 Q-loop/lid; other site 697284001807 ABC transporter signature motif; other site 697284001808 Walker B; other site 697284001809 D-loop; other site 697284001810 H-loop/switch region; other site 697284001811 FOG: CBS domain [General function prediction only]; Region: COG0517 697284001812 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 697284001813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284001814 dimer interface [polypeptide binding]; other site 697284001815 conserved gate region; other site 697284001816 ABC-ATPase subunit interface; other site 697284001817 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 697284001818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284001819 dimer interface [polypeptide binding]; other site 697284001820 conserved gate region; other site 697284001821 ABC-ATPase subunit interface; other site 697284001822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697284001823 Coenzyme A binding pocket [chemical binding]; other site 697284001824 Protein of unknown function (DUF402); Region: DUF402; cl00979 697284001825 epoxyqueuosine reductase; Region: TIGR00276 697284001826 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 697284001827 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 697284001828 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 697284001829 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697284001830 Zn2+ binding site [ion binding]; other site 697284001831 Mg2+ binding site [ion binding]; other site 697284001832 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001833 MULE transposase domain; Region: MULE; pfam10551 697284001834 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 697284001835 homodecamer interface [polypeptide binding]; other site 697284001836 GTP cyclohydrolase I; Provisional; Region: PLN03044 697284001837 active site 697284001838 putative catalytic site residues [active] 697284001839 zinc binding site [ion binding]; other site 697284001840 GTP-CH-I/GFRP interaction surface; other site 697284001841 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 697284001842 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 697284001843 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 697284001844 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 697284001845 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 697284001846 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 697284001847 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 697284001848 nucleophilic elbow; other site 697284001849 catalytic triad; other site 697284001850 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 697284001851 Transcriptional regulator [Transcription]; Region: IclR; COG1414 697284001852 Bacterial transcriptional regulator; Region: IclR; pfam01614 697284001853 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 697284001854 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 697284001855 aconitate hydratase; Validated; Region: PRK09277 697284001856 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 697284001857 substrate binding site [chemical binding]; other site 697284001858 ligand binding site [chemical binding]; other site 697284001859 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 697284001860 substrate binding site [chemical binding]; other site 697284001861 Putative amidase domain; Region: Amidase_6; pfam12671 697284001862 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 697284001863 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 697284001864 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 697284001865 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 697284001866 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 697284001867 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 697284001868 NAD binding site [chemical binding]; other site 697284001869 homotetramer interface [polypeptide binding]; other site 697284001870 homodimer interface [polypeptide binding]; other site 697284001871 substrate binding site [chemical binding]; other site 697284001872 active site 697284001873 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 697284001874 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 697284001875 active site 697284001876 dimerization interface [polypeptide binding]; other site 697284001877 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 697284001878 biotin synthase; Validated; Region: PRK06256 697284001879 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697284001880 FeS/SAM binding site; other site 697284001881 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 697284001882 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 697284001883 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 697284001884 active site 697284001885 dimer interface [polypeptide binding]; other site 697284001886 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 697284001887 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 697284001888 active site 697284001889 FMN binding site [chemical binding]; other site 697284001890 substrate binding site [chemical binding]; other site 697284001891 3Fe-4S cluster binding site [ion binding]; other site 697284001892 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 697284001893 domain_subunit interface; other site 697284001894 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 697284001895 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 697284001896 inhibitor-cofactor binding pocket; inhibition site 697284001897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284001898 catalytic residue [active] 697284001899 Transcriptional regulator [Transcription]; Region: LytR; COG1316 697284001900 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 697284001901 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 697284001902 catalytic triad [active] 697284001903 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 697284001904 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 697284001905 NodB motif; other site 697284001906 active site 697284001907 catalytic site [active] 697284001908 Zn binding site [ion binding]; other site 697284001909 Transposase domain (DUF772); Region: DUF772; pfam05598 697284001910 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 697284001911 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697284001912 putative DNA binding site [nucleotide binding]; other site 697284001913 putative Zn2+ binding site [ion binding]; other site 697284001914 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 697284001915 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 697284001916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284001917 Walker A/P-loop; other site 697284001918 ATP binding site [chemical binding]; other site 697284001919 Q-loop/lid; other site 697284001920 ABC transporter signature motif; other site 697284001921 Walker B; other site 697284001922 D-loop; other site 697284001923 H-loop/switch region; other site 697284001924 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 697284001925 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 697284001926 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 697284001927 Walker A/P-loop; other site 697284001928 ATP binding site [chemical binding]; other site 697284001929 Q-loop/lid; other site 697284001930 ABC transporter signature motif; other site 697284001931 Walker B; other site 697284001932 D-loop; other site 697284001933 H-loop/switch region; other site 697284001934 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 697284001935 GMP synthase; Reviewed; Region: guaA; PRK00074 697284001936 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 697284001937 AMP/PPi binding site [chemical binding]; other site 697284001938 candidate oxyanion hole; other site 697284001939 catalytic triad [active] 697284001940 potential glutamine specificity residues [chemical binding]; other site 697284001941 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 697284001942 ATP Binding subdomain [chemical binding]; other site 697284001943 Ligand Binding sites [chemical binding]; other site 697284001944 Dimerization subdomain; other site 697284001945 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001946 MULE transposase domain; Region: MULE; pfam10551 697284001947 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284001948 non-specific DNA binding site [nucleotide binding]; other site 697284001949 salt bridge; other site 697284001950 sequence-specific DNA binding site [nucleotide binding]; other site 697284001951 D-alanine--D-lactate ligase; Provisional; Region: vanB; PRK14568 697284001952 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 697284001953 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 697284001954 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 697284001955 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001956 MULE transposase domain; Region: MULE; pfam10551 697284001957 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 697284001958 Sulfate transporter family; Region: Sulfate_transp; pfam00916 697284001959 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001960 MULE transposase domain; Region: MULE; pfam10551 697284001961 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697284001962 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697284001963 DNA binding site [nucleotide binding] 697284001964 domain linker motif; other site 697284001965 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 697284001966 dimerization interface [polypeptide binding]; other site 697284001967 ligand binding site [chemical binding]; other site 697284001968 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 697284001969 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 697284001970 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 697284001971 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 697284001972 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 697284001973 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 697284001974 substrate binding site [chemical binding]; other site 697284001975 ATP binding site [chemical binding]; other site 697284001976 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 697284001977 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 697284001978 tetrameric interface [polypeptide binding]; other site 697284001979 NAD binding site [chemical binding]; other site 697284001980 catalytic residues [active] 697284001981 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 697284001982 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 697284001983 PYR/PP interface [polypeptide binding]; other site 697284001984 dimer interface [polypeptide binding]; other site 697284001985 TPP binding site [chemical binding]; other site 697284001986 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 697284001987 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 697284001988 TPP-binding site; other site 697284001989 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 697284001990 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 697284001991 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 697284001992 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 697284001993 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284001994 MULE transposase domain; Region: MULE; pfam10551 697284001995 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 697284001996 Predicted amidohydrolase [General function prediction only]; Region: COG0388 697284001997 putative active site [active] 697284001998 catalytic triad [active] 697284001999 putative dimer interface [polypeptide binding]; other site 697284002000 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 697284002001 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 697284002002 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 697284002003 NAD binding site [chemical binding]; other site 697284002004 ATP-grasp domain; Region: ATP-grasp; pfam02222 697284002005 adenylosuccinate lyase; Provisional; Region: PRK07492 697284002006 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 697284002007 tetramer interface [polypeptide binding]; other site 697284002008 active site 697284002009 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 697284002010 ATP binding site [chemical binding]; other site 697284002011 active site 697284002012 substrate binding site [chemical binding]; other site 697284002013 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 697284002014 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 697284002015 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 697284002016 putative active site [active] 697284002017 catalytic triad [active] 697284002018 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 697284002019 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 697284002020 dimerization interface [polypeptide binding]; other site 697284002021 ATP binding site [chemical binding]; other site 697284002022 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 697284002023 dimerization interface [polypeptide binding]; other site 697284002024 ATP binding site [chemical binding]; other site 697284002025 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 697284002026 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 697284002027 active site 697284002028 tetramer interface [polypeptide binding]; other site 697284002029 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697284002030 active site 697284002031 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 697284002032 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 697284002033 dimerization interface [polypeptide binding]; other site 697284002034 putative ATP binding site [chemical binding]; other site 697284002035 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 697284002036 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 697284002037 active site 697284002038 substrate binding site [chemical binding]; other site 697284002039 cosubstrate binding site; other site 697284002040 catalytic site [active] 697284002041 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 697284002042 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 697284002043 purine monophosphate binding site [chemical binding]; other site 697284002044 dimer interface [polypeptide binding]; other site 697284002045 putative catalytic residues [active] 697284002046 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 697284002047 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 697284002048 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 697284002049 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 697284002050 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 697284002051 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 697284002052 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 697284002053 nudix motif; other site 697284002054 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 697284002055 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 697284002056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 697284002057 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 697284002058 putative active site [active] 697284002059 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 697284002060 putative active site [active] 697284002061 putative lipid kinase; Reviewed; Region: PRK13337 697284002062 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 697284002063 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 697284002064 TRAM domain; Region: TRAM; cl01282 697284002065 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 697284002066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284002067 S-adenosylmethionine binding site [chemical binding]; other site 697284002068 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 697284002069 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 697284002070 Int/Topo IB signature motif; other site 697284002071 Domain of unknown function (DUF955); Region: DUF955; cl01076 697284002072 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697284002073 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284002074 non-specific DNA binding site [nucleotide binding]; other site 697284002075 salt bridge; other site 697284002076 sequence-specific DNA binding site [nucleotide binding]; other site 697284002077 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 697284002078 non-specific DNA binding site [nucleotide binding]; other site 697284002079 salt bridge; other site 697284002080 sequence-specific DNA binding site [nucleotide binding]; other site 697284002081 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697284002082 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284002083 non-specific DNA binding site [nucleotide binding]; other site 697284002084 salt bridge; other site 697284002085 sequence-specific DNA binding site [nucleotide binding]; other site 697284002086 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284002087 non-specific DNA binding site [nucleotide binding]; other site 697284002088 salt bridge; other site 697284002089 sequence-specific DNA binding site [nucleotide binding]; other site 697284002090 Helix-turn-helix domain; Region: HTH_17; pfam12728 697284002091 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 697284002092 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 697284002093 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002094 MULE transposase domain; Region: MULE; pfam10551 697284002095 Replication initiation factor; Region: Rep_trans; pfam02486 697284002096 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 697284002097 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697284002098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284002099 non-specific DNA binding site [nucleotide binding]; other site 697284002100 salt bridge; other site 697284002101 sequence-specific DNA binding site [nucleotide binding]; other site 697284002102 Replication initiation factor; Region: Rep_trans; pfam02486 697284002103 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 697284002104 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 697284002105 YwiC-like protein; Region: YwiC; pfam14256 697284002106 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 697284002107 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 697284002108 Walker A motif; other site 697284002109 ATP binding site [chemical binding]; other site 697284002110 Walker B motif; other site 697284002111 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 697284002112 TcpE family; Region: TcpE; pfam12648 697284002113 AAA-like domain; Region: AAA_10; pfam12846 697284002114 Domain of unknown function DUF87; Region: DUF87; pfam01935 697284002115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284002116 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 697284002117 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 697284002118 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 697284002119 NlpC/P60 family; Region: NLPC_P60; pfam00877 697284002120 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 697284002121 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 697284002122 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 697284002123 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002124 MULE transposase domain; Region: MULE; pfam10551 697284002125 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284002126 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284002127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284002128 Homeodomain-like domain; Region: HTH_23; cl17451 697284002129 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284002130 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 697284002131 AntA/AntB antirepressor; Region: AntA; cl01430 697284002132 Integrase core domain; Region: rve; pfam00665 697284002133 Integrase core domain; Region: rve_3; pfam13683 697284002134 Cache domain; Region: Cache_1; pfam02743 697284002135 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697284002136 dimerization interface [polypeptide binding]; other site 697284002137 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 697284002138 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 697284002139 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 697284002140 dimer interface [polypeptide binding]; other site 697284002141 putative CheW interface [polypeptide binding]; other site 697284002142 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 697284002143 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 697284002144 DNA binding residues [nucleotide binding] 697284002145 dimerization interface [polypeptide binding]; other site 697284002146 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 697284002147 active site 697284002148 catalytic triad [active] 697284002149 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 697284002150 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 697284002151 Walker A/P-loop; other site 697284002152 ATP binding site [chemical binding]; other site 697284002153 Q-loop/lid; other site 697284002154 ABC transporter signature motif; other site 697284002155 Walker B; other site 697284002156 D-loop; other site 697284002157 H-loop/switch region; other site 697284002158 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 697284002159 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002160 MULE transposase domain; Region: MULE; pfam10551 697284002161 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 697284002162 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 697284002163 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 697284002164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284002165 Walker A/P-loop; other site 697284002166 ATP binding site [chemical binding]; other site 697284002167 Q-loop/lid; other site 697284002168 ABC transporter signature motif; other site 697284002169 Walker B; other site 697284002170 D-loop; other site 697284002171 H-loop/switch region; other site 697284002172 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 697284002173 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 697284002174 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 697284002175 heat shock protein 90; Provisional; Region: PRK05218 697284002176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284002177 ATP binding site [chemical binding]; other site 697284002178 Mg2+ binding site [ion binding]; other site 697284002179 G-X-G motif; other site 697284002180 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002181 MULE transposase domain; Region: MULE; pfam10551 697284002182 Fic family protein [Function unknown]; Region: COG3177 697284002183 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 697284002184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284002185 Walker A/P-loop; other site 697284002186 ATP binding site [chemical binding]; other site 697284002187 Q-loop/lid; other site 697284002188 ABC transporter signature motif; other site 697284002189 Walker B; other site 697284002190 D-loop; other site 697284002191 H-loop/switch region; other site 697284002192 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 697284002193 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 697284002194 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 697284002195 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 697284002196 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 697284002197 active site 697284002198 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 697284002199 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 697284002200 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 697284002201 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 697284002202 NAD(P) binding site [chemical binding]; other site 697284002203 homotetramer interface [polypeptide binding]; other site 697284002204 homodimer interface [polypeptide binding]; other site 697284002205 active site 697284002206 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002207 MULE transposase domain; Region: MULE; pfam10551 697284002208 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 697284002209 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 697284002210 Homeodomain-like domain; Region: HTH_23; pfam13384 697284002211 Winged helix-turn helix; Region: HTH_29; pfam13551 697284002212 Winged helix-turn helix; Region: HTH_33; pfam13592 697284002213 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697284002214 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 697284002215 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 697284002216 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 697284002217 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 697284002218 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 697284002219 dimer interface [polypeptide binding]; other site 697284002220 active site 697284002221 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 697284002222 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 697284002223 active site 697284002224 ADP-ribosyltransferase exoenzyme; Region: ADPrib_exo_Tox; pfam03496 697284002225 active site 697284002226 ADP-ribosylating toxin turn-turn motif; other site 697284002227 Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495 697284002228 Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495 697284002229 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 697284002230 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002231 MULE transposase domain; Region: MULE; pfam10551 697284002232 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 697284002233 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 697284002234 active site 697284002235 NAD binding site [chemical binding]; other site 697284002236 metal binding site [ion binding]; metal-binding site 697284002237 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 697284002238 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 697284002239 tetramerization interface [polypeptide binding]; other site 697284002240 NAD(P) binding site [chemical binding]; other site 697284002241 catalytic residues [active] 697284002242 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002243 MULE transposase domain; Region: MULE; pfam10551 697284002244 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 697284002245 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 697284002246 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 697284002247 FMN binding site [chemical binding]; other site 697284002248 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002249 MULE transposase domain; Region: MULE; pfam10551 697284002250 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002251 MULE transposase domain; Region: MULE; pfam10551 697284002252 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 697284002253 Putative esterase; Region: Esterase; pfam00756 697284002254 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 697284002255 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 697284002256 TPP-binding site [chemical binding]; other site 697284002257 heterodimer interface [polypeptide binding]; other site 697284002258 tetramer interface [polypeptide binding]; other site 697284002259 phosphorylation loop region [posttranslational modification] 697284002260 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 697284002261 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 697284002262 alpha subunit interface [polypeptide binding]; other site 697284002263 TPP binding site [chemical binding]; other site 697284002264 heterodimer interface [polypeptide binding]; other site 697284002265 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 697284002266 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 697284002267 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 697284002268 E3 interaction surface; other site 697284002269 lipoyl attachment site [posttranslational modification]; other site 697284002270 e3 binding domain; Region: E3_binding; pfam02817 697284002271 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 697284002272 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 697284002273 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 697284002274 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 697284002275 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 697284002276 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 697284002277 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 697284002278 active site 697284002279 catalytic site [active] 697284002280 metal binding site [ion binding]; metal-binding site 697284002281 dimer interface [polypeptide binding]; other site 697284002282 glycerate dehydrogenase; Provisional; Region: PRK06487 697284002283 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 697284002284 putative ligand binding site [chemical binding]; other site 697284002285 putative NAD binding site [chemical binding]; other site 697284002286 catalytic site [active] 697284002287 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 697284002288 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 697284002289 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 697284002290 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697284002291 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 697284002292 Homeodomain-like domain; Region: HTH_23; pfam13384 697284002293 Winged helix-turn helix; Region: HTH_29; pfam13551 697284002294 Winged helix-turn helix; Region: HTH_33; pfam13592 697284002295 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 697284002296 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 697284002297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284002298 ABC-ATPase subunit interface; other site 697284002299 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 697284002300 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 697284002301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284002302 dimer interface [polypeptide binding]; other site 697284002303 conserved gate region; other site 697284002304 ABC-ATPase subunit interface; other site 697284002305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 697284002306 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 697284002307 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697284002308 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 697284002309 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697284002310 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 697284002311 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 697284002312 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 697284002313 Sporulation inhibitor A; Region: Sda; pfam08970 697284002314 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 697284002315 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 697284002316 catalytic triad [active] 697284002317 conserved cis-peptide bond; other site 697284002318 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 697284002319 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 697284002320 active site 697284002321 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 697284002322 Class III ribonucleotide reductase; Region: RNR_III; cd01675 697284002323 effector binding site; other site 697284002324 active site 697284002325 Zn binding site [ion binding]; other site 697284002326 glycine loop; other site 697284002327 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 697284002328 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 697284002329 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 697284002330 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 697284002331 NAD-dependent deacetylase; Provisional; Region: PRK00481 697284002332 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 697284002333 NAD+ binding site [chemical binding]; other site 697284002334 substrate binding site [chemical binding]; other site 697284002335 Zn binding site [ion binding]; other site 697284002336 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002337 MULE transposase domain; Region: MULE; pfam10551 697284002338 H+ Antiporter protein; Region: 2A0121; TIGR00900 697284002339 GtrA-like protein; Region: GtrA; pfam04138 697284002340 Predicted membrane protein [Function unknown]; Region: COG2246 697284002341 sporulation sigma factor SigK; Reviewed; Region: PRK05803 697284002342 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 697284002343 Probable transposase; Region: OrfB_IS605; pfam01385 697284002344 Probable transposase; Region: OrfB_IS605; pfam01385 697284002345 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 697284002346 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 697284002347 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 697284002348 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 697284002349 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 697284002350 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 697284002351 TM-ABC transporter signature motif; other site 697284002352 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284002353 Walker A/P-loop; other site 697284002354 ATP binding site [chemical binding]; other site 697284002355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284002356 ABC transporter signature motif; other site 697284002357 Walker B; other site 697284002358 D-loop; other site 697284002359 H-loop/switch region; other site 697284002360 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 697284002361 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 697284002362 TPP-binding site [chemical binding]; other site 697284002363 tetramer interface [polypeptide binding]; other site 697284002364 heterodimer interface [polypeptide binding]; other site 697284002365 phosphorylation loop region [posttranslational modification] 697284002366 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 697284002367 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 697284002368 alpha subunit interface [polypeptide binding]; other site 697284002369 TPP binding site [chemical binding]; other site 697284002370 heterodimer interface [polypeptide binding]; other site 697284002371 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 697284002372 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 697284002373 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 697284002374 E3 interaction surface; other site 697284002375 lipoyl attachment site [posttranslational modification]; other site 697284002376 e3 binding domain; Region: E3_binding; pfam02817 697284002377 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 697284002378 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 697284002379 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 697284002380 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 697284002381 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 697284002382 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 697284002383 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 697284002384 Phenylacetic acid degradation B; Region: PaaB; pfam06243 697284002385 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 697284002386 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 697284002387 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 697284002388 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 697284002389 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 697284002390 tetramerization interface [polypeptide binding]; other site 697284002391 NAD(P) binding site [chemical binding]; other site 697284002392 catalytic residues [active] 697284002393 EthD domain; Region: EthD; cl17553 697284002394 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 697284002395 CoenzymeA binding site [chemical binding]; other site 697284002396 subunit interaction site [polypeptide binding]; other site 697284002397 PHB binding site; other site 697284002398 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 697284002399 enoyl-CoA hydratase; Provisional; Region: PRK07657 697284002400 substrate binding site [chemical binding]; other site 697284002401 oxyanion hole (OAH) forming residues; other site 697284002402 trimer interface [polypeptide binding]; other site 697284002403 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 697284002404 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 697284002405 acyl-activating enzyme (AAE) consensus motif; other site 697284002406 AMP binding site [chemical binding]; other site 697284002407 active site 697284002408 CoA binding site [chemical binding]; other site 697284002409 enoyl-CoA hydratase; Provisional; Region: PRK05862 697284002410 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 697284002411 substrate binding site [chemical binding]; other site 697284002412 oxyanion hole (OAH) forming residues; other site 697284002413 trimer interface [polypeptide binding]; other site 697284002414 enoyl-CoA hydratase; Provisional; Region: PRK08140 697284002415 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 697284002416 substrate binding site [chemical binding]; other site 697284002417 oxyanion hole (OAH) forming residues; other site 697284002418 trimer interface [polypeptide binding]; other site 697284002419 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 697284002420 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 697284002421 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 697284002422 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 697284002423 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 697284002424 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 697284002425 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 697284002426 dimer interface [polypeptide binding]; other site 697284002427 active site 697284002428 Predicted thioesterase [General function prediction only]; Region: COG5496 697284002429 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 697284002430 PaaX-like protein; Region: PaaX; pfam07848 697284002431 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 697284002432 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002433 MULE transposase domain; Region: MULE; pfam10551 697284002434 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 697284002435 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 697284002436 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 697284002437 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 697284002438 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 697284002439 catalytic residues [active] 697284002440 catalytic nucleophile [active] 697284002441 Recombinase; Region: Recombinase; pfam07508 697284002442 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 697284002443 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697284002444 sporulation sigma factor SigK; Reviewed; Region: PRK05803 697284002445 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697284002446 DNA binding residues [nucleotide binding] 697284002447 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 697284002448 Predicted membrane protein [Function unknown]; Region: COG2323 697284002449 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 697284002450 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 697284002451 stage V sporulation protein AD; Provisional; Region: PRK12404 697284002452 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 697284002453 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 697284002454 MoxR-like ATPases [General function prediction only]; Region: COG0714 697284002455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697284002456 Walker A motif; other site 697284002457 ATP binding site [chemical binding]; other site 697284002458 Walker B motif; other site 697284002459 arginine finger; other site 697284002460 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 697284002461 Protein of unknown function DUF58; Region: DUF58; pfam01882 697284002462 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 697284002463 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 697284002464 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 697284002465 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 697284002466 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697284002467 active site 697284002468 motif I; other site 697284002469 motif II; other site 697284002470 GTPase YqeH; Provisional; Region: PRK13796 697284002471 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 697284002472 GTP/Mg2+ binding site [chemical binding]; other site 697284002473 G4 box; other site 697284002474 G5 box; other site 697284002475 G1 box; other site 697284002476 Switch I region; other site 697284002477 G2 box; other site 697284002478 G3 box; other site 697284002479 Switch II region; other site 697284002480 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 697284002481 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 697284002482 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 697284002483 shikimate binding site; other site 697284002484 NAD(P) binding site [chemical binding]; other site 697284002485 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 697284002486 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 697284002487 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 697284002488 active site 697284002489 (T/H)XGH motif; other site 697284002490 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697284002491 Zn2+ binding site [ion binding]; other site 697284002492 Mg2+ binding site [ion binding]; other site 697284002493 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 697284002494 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 697284002495 S1 domain; Region: S1_2; pfam13509 697284002496 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 697284002497 RNA binding site [nucleotide binding]; other site 697284002498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284002499 S-adenosylmethionine binding site [chemical binding]; other site 697284002500 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 697284002501 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 697284002502 HIGH motif; other site 697284002503 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 697284002504 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 697284002505 active site 697284002506 KMSKS motif; other site 697284002507 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 697284002508 tRNA binding surface [nucleotide binding]; other site 697284002509 late competence protein ComER; Validated; Region: PRK07680 697284002510 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 697284002511 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 697284002512 Helix-hairpin-helix motif; Region: HHH; pfam00633 697284002513 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248 697284002514 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 697284002515 homodimer interface [polypeptide binding]; other site 697284002516 substrate-cofactor binding pocket; other site 697284002517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284002518 catalytic residue [active] 697284002519 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 697284002520 catalytic motif [active] 697284002521 Zn binding site [ion binding]; other site 697284002522 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 697284002523 Competence protein; Region: Competence; pfam03772 697284002524 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 697284002525 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 697284002526 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 697284002527 Int/Topo IB signature motif; other site 697284002528 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697284002529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284002530 non-specific DNA binding site [nucleotide binding]; other site 697284002531 salt bridge; other site 697284002532 sequence-specific DNA binding site [nucleotide binding]; other site 697284002533 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697284002534 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284002535 non-specific DNA binding site [nucleotide binding]; other site 697284002536 salt bridge; other site 697284002537 sequence-specific DNA binding site [nucleotide binding]; other site 697284002538 AntA/AntB antirepressor; Region: AntA; cl01430 697284002539 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 697284002540 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 697284002541 Prophage antirepressor [Transcription]; Region: COG3617 697284002542 BRO family, N-terminal domain; Region: Bro-N; smart01040 697284002543 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 697284002544 ORF6N domain; Region: ORF6N; pfam10543 697284002545 ORF6C domain; Region: ORF6C; pfam10552 697284002546 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 697284002547 AAA domain; Region: AAA_23; pfam13476 697284002548 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 697284002549 Herpesvirus ICP4-like protein N-terminal region; Region: Herpes_ICP4_N; cl17480 697284002550 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 697284002551 Protein of unknown function (DUF968); Region: DUF968; pfam06147 697284002552 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 697284002553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697284002554 Walker A motif; other site 697284002555 ATP binding site [chemical binding]; other site 697284002556 Walker B motif; other site 697284002557 arginine finger; other site 697284002558 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 697284002559 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 697284002560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284002561 DNA methylase; Region: N6_N4_Mtase; pfam01555 697284002562 positive control sigma-like factor; Validated; Region: PRK06930 697284002563 Uncharacterized conserved protein [Function unknown]; Region: COG5484 697284002564 Phage terminase small subunit; Region: Phage_terminase; pfam10668 697284002565 Phage terminase large subunit; Region: Terminase_3; cl12054 697284002566 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002567 MULE transposase domain; Region: MULE; pfam10551 697284002568 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002569 MULE transposase domain; Region: MULE; pfam10551 697284002570 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002571 MULE transposase domain; Region: MULE; pfam10551 697284002572 peroxiredoxin; Region: AhpC; TIGR03137 697284002573 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 697284002574 dimer interface [polypeptide binding]; other site 697284002575 decamer (pentamer of dimers) interface [polypeptide binding]; other site 697284002576 catalytic triad [active] 697284002577 peroxidatic and resolving cysteines [active] 697284002578 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 697284002579 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 697284002580 catalytic residue [active] 697284002581 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 697284002582 catalytic residues [active] 697284002583 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 697284002584 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 697284002585 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 697284002586 DNA binding site [nucleotide binding] 697284002587 active site 697284002588 Int/Topo IB signature motif; other site 697284002589 catalytic residues [active] 697284002590 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002591 MULE transposase domain; Region: MULE; pfam10551 697284002592 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 697284002593 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 697284002594 putative hexamer interface [polypeptide binding]; other site 697284002595 putative hexagonal pore; other site 697284002596 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 697284002597 G1 box; other site 697284002598 GTP/Mg2+ binding site [chemical binding]; other site 697284002599 G2 box; other site 697284002600 Switch I region; other site 697284002601 G3 box; other site 697284002602 Switch II region; other site 697284002603 G4 box; other site 697284002604 G5 box; other site 697284002605 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 697284002606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284002607 active site 697284002608 phosphorylation site [posttranslational modification] 697284002609 intermolecular recognition site; other site 697284002610 dimerization interface [polypeptide binding]; other site 697284002611 ANTAR domain; Region: ANTAR; pfam03861 697284002612 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 697284002613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 697284002614 Histidine kinase; Region: HisKA_2; pfam07568 697284002615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284002616 ATP binding site [chemical binding]; other site 697284002617 Mg2+ binding site [ion binding]; other site 697284002618 G-X-G motif; other site 697284002619 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 697284002620 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 697284002621 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 697284002622 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 697284002623 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 697284002624 putative hexamer interface [polypeptide binding]; other site 697284002625 putative hexagonal pore; other site 697284002626 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 697284002627 Hexamer interface [polypeptide binding]; other site 697284002628 Hexagonal pore residue; other site 697284002629 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 697284002630 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 697284002631 Hexamer interface [polypeptide binding]; other site 697284002632 Hexagonal pore residue; other site 697284002633 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 697284002634 putative catalytic cysteine [active] 697284002635 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 697284002636 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 697284002637 Hexamer interface [polypeptide binding]; other site 697284002638 Putative hexagonal pore residue; other site 697284002639 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 697284002640 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 697284002641 Propanediol utilisation protein PduL; Region: PduL; pfam06130 697284002642 Propanediol utilisation protein PduL; Region: PduL; pfam06130 697284002643 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 697284002644 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 697284002645 Hexamer/Pentamer interface [polypeptide binding]; other site 697284002646 central pore; other site 697284002647 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 697284002648 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 697284002649 putative hexamer interface [polypeptide binding]; other site 697284002650 putative hexagonal pore; other site 697284002651 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 697284002652 putative hexamer interface [polypeptide binding]; other site 697284002653 putative hexagonal pore; other site 697284002654 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 697284002655 hypothetical protein; Provisional; Region: PRK08317 697284002656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284002657 S-adenosylmethionine binding site [chemical binding]; other site 697284002658 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697284002659 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284002660 non-specific DNA binding site [nucleotide binding]; other site 697284002661 salt bridge; other site 697284002662 sequence-specific DNA binding site [nucleotide binding]; other site 697284002663 Predicted integral membrane protein [Function unknown]; Region: COG5652 697284002664 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 697284002665 Protein of unknown function DUF86; Region: DUF86; cl01031 697284002666 Predicted transcriptional regulator [Transcription]; Region: COG2345 697284002667 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697284002668 putative DNA binding site [nucleotide binding]; other site 697284002669 putative Zn2+ binding site [ion binding]; other site 697284002670 selenophosphate synthetase; Provisional; Region: PRK00943 697284002671 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 697284002672 dimerization interface [polypeptide binding]; other site 697284002673 putative ATP binding site [chemical binding]; other site 697284002674 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 697284002675 tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167 697284002676 active site residue [active] 697284002677 YtxH-like protein; Region: YtxH; pfam12732 697284002678 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002679 MULE transposase domain; Region: MULE; pfam10551 697284002680 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 697284002681 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 697284002682 Probable transposase; Region: OrfB_IS605; pfam01385 697284002683 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 697284002684 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 697284002685 Probable transposase; Region: OrfB_IS605; pfam01385 697284002686 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002687 MULE transposase domain; Region: MULE; pfam10551 697284002688 Probable transposase; Region: OrfB_IS605; pfam01385 697284002689 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 697284002690 alpha-galactosidase; Provisional; Region: PRK15076 697284002691 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 697284002692 NAD binding site [chemical binding]; other site 697284002693 sugar binding site [chemical binding]; other site 697284002694 divalent metal binding site [ion binding]; other site 697284002695 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 697284002696 dimer interface [polypeptide binding]; other site 697284002697 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 697284002698 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002699 MULE transposase domain; Region: MULE; pfam10551 697284002700 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2; Region: ETX_MTX2; pfam03318 697284002701 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002702 MULE transposase domain; Region: MULE; pfam10551 697284002703 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 697284002704 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 697284002705 DNA binding residues [nucleotide binding] 697284002706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284002707 Major Facilitator Superfamily; Region: MFS_1; pfam07690 697284002708 putative substrate translocation pore; other site 697284002709 glutamate racemase; Provisional; Region: PRK00865 697284002710 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 697284002711 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 697284002712 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 697284002713 putative active site [active] 697284002714 Zn binding site [ion binding]; other site 697284002715 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 697284002716 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 697284002717 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 697284002718 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 697284002719 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002720 MULE transposase domain; Region: MULE; pfam10551 697284002721 Domain of unknown function DUF20; Region: UPF0118; pfam01594 697284002722 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 697284002723 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 697284002724 active site 697284002725 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 697284002726 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 697284002727 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 697284002728 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 697284002729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 697284002730 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 697284002731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 697284002732 drug efflux system protein MdtG; Provisional; Region: PRK09874 697284002733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284002734 putative substrate translocation pore; other site 697284002735 Coat F domain; Region: Coat_F; pfam07875 697284002736 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002737 MULE transposase domain; Region: MULE; pfam10551 697284002738 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 697284002739 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 697284002740 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 697284002741 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 697284002742 Integral membrane protein DUF92; Region: DUF92; pfam01940 697284002743 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 697284002744 oligoendopeptidase F; Region: pepF; TIGR00181 697284002745 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 697284002746 active site 697284002747 Zn binding site [ion binding]; other site 697284002748 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 697284002749 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 697284002750 DNA-binding site [nucleotide binding]; DNA binding site 697284002751 RNA-binding motif; other site 697284002752 hypothetical protein; Validated; Region: PRK00110 697284002753 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 697284002754 FMN binding site [chemical binding]; other site 697284002755 dimer interface [polypeptide binding]; other site 697284002756 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 697284002757 6-phosphofructokinase; Provisional; Region: PRK03202 697284002758 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 697284002759 active site 697284002760 ADP/pyrophosphate binding site [chemical binding]; other site 697284002761 dimerization interface [polypeptide binding]; other site 697284002762 allosteric effector site; other site 697284002763 fructose-1,6-bisphosphate binding site; other site 697284002764 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 697284002765 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 697284002766 Predicted flavoprotein [General function prediction only]; Region: COG0431 697284002767 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 697284002768 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 697284002769 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 697284002770 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 697284002771 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 697284002772 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 697284002773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284002774 Walker A/P-loop; other site 697284002775 ATP binding site [chemical binding]; other site 697284002776 Q-loop/lid; other site 697284002777 ABC transporter signature motif; other site 697284002778 Walker B; other site 697284002779 D-loop; other site 697284002780 H-loop/switch region; other site 697284002781 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 697284002782 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 697284002783 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 697284002784 Walker A/P-loop; other site 697284002785 ATP binding site [chemical binding]; other site 697284002786 Q-loop/lid; other site 697284002787 ABC transporter signature motif; other site 697284002788 Walker B; other site 697284002789 D-loop; other site 697284002790 H-loop/switch region; other site 697284002791 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 697284002792 Uncharacterized conserved protein [Function unknown]; Region: COG1284 697284002793 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 697284002794 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 697284002795 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002796 MULE transposase domain; Region: MULE; pfam10551 697284002797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 697284002798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 697284002799 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 697284002800 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 697284002801 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 697284002802 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 697284002803 ATP binding site [chemical binding]; other site 697284002804 Mg++ binding site [ion binding]; other site 697284002805 motif III; other site 697284002806 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697284002807 nucleotide binding region [chemical binding]; other site 697284002808 ATP-binding site [chemical binding]; other site 697284002809 Predicted integral membrane protein [Function unknown]; Region: COG5578 697284002810 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 697284002811 active site 697284002812 intersubunit interactions; other site 697284002813 catalytic residue [active] 697284002814 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 697284002815 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 697284002816 putative active site [active] 697284002817 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002818 MULE transposase domain; Region: MULE; pfam10551 697284002819 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 697284002820 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 697284002821 dimer interface [polypeptide binding]; other site 697284002822 catalytic triad [active] 697284002823 peroxidatic and resolving cysteines [active] 697284002824 Transcriptional regulator [Transcription]; Region: LysR; COG0583 697284002825 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 697284002826 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 697284002827 putative dimerization interface [polypeptide binding]; other site 697284002828 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 697284002829 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 697284002830 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 697284002831 DNA binding residues [nucleotide binding] 697284002832 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002833 MULE transposase domain; Region: MULE; pfam10551 697284002834 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 697284002835 MPN+ (JAMM) motif; other site 697284002836 Zinc-binding site [ion binding]; other site 697284002837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284002838 Major Facilitator Superfamily; Region: MFS_1; pfam07690 697284002839 putative substrate translocation pore; other site 697284002840 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 697284002841 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 697284002842 catalytic residues [active] 697284002843 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 697284002844 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 697284002845 active site 697284002846 catalytic residues [active] 697284002847 metal binding site [ion binding]; metal-binding site 697284002848 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 697284002849 DNA polymerase IV; Validated; Region: PRK01810 697284002850 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 697284002851 active site 697284002852 DNA binding site [nucleotide binding] 697284002853 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 697284002854 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 697284002855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 697284002856 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 697284002857 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 697284002858 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 697284002859 quinone interaction residues [chemical binding]; other site 697284002860 active site 697284002861 catalytic residues [active] 697284002862 FMN binding site [chemical binding]; other site 697284002863 substrate binding site [chemical binding]; other site 697284002864 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 697284002865 synthetase active site [active] 697284002866 NTP binding site [chemical binding]; other site 697284002867 metal binding site [ion binding]; metal-binding site 697284002868 Domain of unknown function (DUF309); Region: DUF309; pfam03745 697284002869 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 697284002870 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 697284002871 active site 697284002872 uracil binding [chemical binding]; other site 697284002873 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697284002874 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 697284002875 active site 697284002876 motif I; other site 697284002877 motif II; other site 697284002878 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 697284002879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284002880 Major Facilitator Superfamily; Region: MFS_1; pfam07690 697284002881 putative substrate translocation pore; other site 697284002882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284002883 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 697284002884 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 697284002885 catalytic residues [active] 697284002886 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 697284002887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284002888 S-adenosylmethionine binding site [chemical binding]; other site 697284002889 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 697284002890 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 697284002891 tetramer (dimer of dimers) interface [polypeptide binding]; other site 697284002892 active site 697284002893 dimer interface [polypeptide binding]; other site 697284002894 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 697284002895 glycerol kinase; Provisional; Region: glpK; PRK00047 697284002896 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 697284002897 N- and C-terminal domain interface [polypeptide binding]; other site 697284002898 active site 697284002899 MgATP binding site [chemical binding]; other site 697284002900 catalytic site [active] 697284002901 metal binding site [ion binding]; metal-binding site 697284002902 glycerol binding site [chemical binding]; other site 697284002903 homotetramer interface [polypeptide binding]; other site 697284002904 homodimer interface [polypeptide binding]; other site 697284002905 FBP binding site [chemical binding]; other site 697284002906 protein IIAGlc interface [polypeptide binding]; other site 697284002907 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 697284002908 amphipathic channel; other site 697284002909 Asn-Pro-Ala signature motifs; other site 697284002910 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 697284002911 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697284002912 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284002913 non-specific DNA binding site [nucleotide binding]; other site 697284002914 salt bridge; other site 697284002915 sequence-specific DNA binding site [nucleotide binding]; other site 697284002916 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697284002917 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284002918 non-specific DNA binding site [nucleotide binding]; other site 697284002919 salt bridge; other site 697284002920 sequence-specific DNA binding site [nucleotide binding]; other site 697284002921 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697284002922 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284002923 non-specific DNA binding site [nucleotide binding]; other site 697284002924 salt bridge; other site 697284002925 sequence-specific DNA binding site [nucleotide binding]; other site 697284002926 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 697284002927 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 697284002928 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 697284002929 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 697284002930 active site 697284002931 metal binding site [ion binding]; metal-binding site 697284002932 DNA binding site [nucleotide binding] 697284002933 Uncharacterized conserved protein [Function unknown]; Region: COG4717 697284002934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284002935 Walker A/P-loop; other site 697284002936 ATP binding site [chemical binding]; other site 697284002937 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 697284002938 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 697284002939 putative substrate binding site [chemical binding]; other site 697284002940 putative ATP binding site [chemical binding]; other site 697284002941 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 697284002942 intersubunit interface [polypeptide binding]; other site 697284002943 active site 697284002944 zinc binding site [ion binding]; other site 697284002945 Na+ binding site [ion binding]; other site 697284002946 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 697284002947 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 697284002948 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 697284002949 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 697284002950 Uncharacterized membrane protein [Function unknown]; Region: COG3949 697284002951 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 697284002952 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 697284002953 Integrase core domain; Region: rve; pfam00665 697284002954 Integrase core domain; Region: rve_3; cl15866 697284002955 HTH-like domain; Region: HTH_21; pfam13276 697284002956 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284002957 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284002958 Homeodomain-like domain; Region: HTH_32; pfam13565 697284002959 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284002960 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284002961 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002962 MULE transposase domain; Region: MULE; pfam10551 697284002963 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 697284002964 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 697284002965 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 697284002966 intersubunit interface [polypeptide binding]; other site 697284002967 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 697284002968 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 697284002969 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 697284002970 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 697284002971 ABC-ATPase subunit interface; other site 697284002972 dimer interface [polypeptide binding]; other site 697284002973 putative PBP binding regions; other site 697284002974 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 697284002975 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 697284002976 ABC-ATPase subunit interface; other site 697284002977 dimer interface [polypeptide binding]; other site 697284002978 putative PBP binding regions; other site 697284002979 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 697284002980 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284002981 MULE transposase domain; Region: MULE; pfam10551 697284002982 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 697284002983 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 697284002984 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 697284002985 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 697284002986 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 697284002987 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 697284002988 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 697284002989 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 697284002990 tetramer interface [polypeptide binding]; other site 697284002991 TPP-binding site [chemical binding]; other site 697284002992 heterodimer interface [polypeptide binding]; other site 697284002993 phosphorylation loop region [posttranslational modification] 697284002994 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 697284002995 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 697284002996 alpha subunit interface [polypeptide binding]; other site 697284002997 TPP binding site [chemical binding]; other site 697284002998 heterodimer interface [polypeptide binding]; other site 697284002999 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 697284003000 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 697284003001 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 697284003002 E3 interaction surface; other site 697284003003 lipoyl attachment site [posttranslational modification]; other site 697284003004 e3 binding domain; Region: E3_binding; pfam02817 697284003005 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 697284003006 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 697284003007 peptidase T-like protein; Region: PepT-like; TIGR01883 697284003008 metal binding site [ion binding]; metal-binding site 697284003009 putative dimer interface [polypeptide binding]; other site 697284003010 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 697284003011 Transposase domain (DUF772); Region: DUF772; pfam05598 697284003012 Transcriptional regulator [Transcription]; Region: LytR; COG1316 697284003013 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 697284003014 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 697284003015 dimer interface [polypeptide binding]; other site 697284003016 ADP-ribose binding site [chemical binding]; other site 697284003017 active site 697284003018 nudix motif; other site 697284003019 metal binding site [ion binding]; metal-binding site 697284003020 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 697284003021 PHP-associated; Region: PHP_C; pfam13263 697284003022 Integral membrane protein DUF95; Region: DUF95; cl00572 697284003023 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 697284003024 metal binding site 2 [ion binding]; metal-binding site 697284003025 putative DNA binding helix; other site 697284003026 metal binding site 1 [ion binding]; metal-binding site 697284003027 dimer interface [polypeptide binding]; other site 697284003028 structural Zn2+ binding site [ion binding]; other site 697284003029 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 697284003030 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 697284003031 hexamer interface [polypeptide binding]; other site 697284003032 ligand binding site [chemical binding]; other site 697284003033 putative active site [active] 697284003034 NAD(P) binding site [chemical binding]; other site 697284003035 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 697284003036 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 697284003037 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 697284003038 active site 697284003039 Int/Topo IB signature motif; other site 697284003040 phosphopentomutase; Provisional; Region: PRK05362 697284003041 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 697284003042 purine nucleoside phosphorylase; Provisional; Region: PRK08202 697284003043 purine nucleoside phosphorylase; Provisional; Region: PRK08202 697284003044 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 697284003045 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 697284003046 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 697284003047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284003048 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 697284003049 Walker A/P-loop; other site 697284003050 ATP binding site [chemical binding]; other site 697284003051 Q-loop/lid; other site 697284003052 ABC transporter signature motif; other site 697284003053 Walker B; other site 697284003054 D-loop; other site 697284003055 H-loop/switch region; other site 697284003056 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 697284003057 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697284003058 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697284003059 DNA binding residues [nucleotide binding] 697284003060 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 697284003061 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 697284003062 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 697284003063 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 697284003064 anti sigma factor interaction site; other site 697284003065 regulatory phosphorylation site [posttranslational modification]; other site 697284003066 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 697284003067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284003068 ATP binding site [chemical binding]; other site 697284003069 Mg2+ binding site [ion binding]; other site 697284003070 G-X-G motif; other site 697284003071 sporulation sigma factor SigF; Validated; Region: PRK05572 697284003072 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697284003073 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 697284003074 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697284003075 DNA binding residues [nucleotide binding] 697284003076 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284003077 MULE transposase domain; Region: MULE; pfam10551 697284003078 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 697284003079 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 697284003080 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 697284003081 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 697284003082 Domain of unknown function (DUF378); Region: DUF378; pfam04070 697284003083 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 697284003084 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 697284003085 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 697284003086 diaminopimelate decarboxylase; Region: lysA; TIGR01048 697284003087 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 697284003088 active site 697284003089 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 697284003090 substrate binding site [chemical binding]; other site 697284003091 catalytic residues [active] 697284003092 dimer interface [polypeptide binding]; other site 697284003093 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284003094 MULE transposase domain; Region: MULE; pfam10551 697284003095 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 697284003096 active site 697284003097 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 697284003098 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 697284003099 catalytic motif [active] 697284003100 Zn binding site [ion binding]; other site 697284003101 RibD C-terminal domain; Region: RibD_C; cl17279 697284003102 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 697284003103 Lumazine binding domain; Region: Lum_binding; pfam00677 697284003104 Lumazine binding domain; Region: Lum_binding; pfam00677 697284003105 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 697284003106 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 697284003107 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 697284003108 dimerization interface [polypeptide binding]; other site 697284003109 active site 697284003110 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 697284003111 homopentamer interface [polypeptide binding]; other site 697284003112 active site 697284003113 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 697284003114 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 697284003115 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 697284003116 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 697284003117 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 697284003118 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 697284003119 transmembrane helices; other site 697284003120 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 697284003121 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 697284003122 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 697284003123 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 697284003124 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 697284003125 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697284003126 RNA binding surface [nucleotide binding]; other site 697284003127 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 697284003128 active site 697284003129 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 697284003130 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 697284003131 catalytic residues [active] 697284003132 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 697284003133 ResB-like family; Region: ResB; pfam05140 697284003134 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 697284003135 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 697284003136 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697284003137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284003138 active site 697284003139 phosphorylation site [posttranslational modification] 697284003140 intermolecular recognition site; other site 697284003141 dimerization interface [polypeptide binding]; other site 697284003142 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697284003143 DNA binding site [nucleotide binding] 697284003144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697284003145 dimerization interface [polypeptide binding]; other site 697284003146 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 697284003147 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697284003148 dimer interface [polypeptide binding]; other site 697284003149 phosphorylation site [posttranslational modification] 697284003150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284003151 ATP binding site [chemical binding]; other site 697284003152 Mg2+ binding site [ion binding]; other site 697284003153 G-X-G motif; other site 697284003154 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 697284003155 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 697284003156 ligand binding site [chemical binding]; other site 697284003157 NAD binding site [chemical binding]; other site 697284003158 dimerization interface [polypeptide binding]; other site 697284003159 catalytic site [active] 697284003160 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 697284003161 putative L-serine binding site [chemical binding]; other site 697284003162 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 697284003163 dimer interface [polypeptide binding]; other site 697284003164 substrate binding site [chemical binding]; other site 697284003165 metal binding sites [ion binding]; metal-binding site 697284003166 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 697284003167 active site residue [active] 697284003168 CAAX protease self-immunity; Region: Abi; pfam02517 697284003169 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 697284003170 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 697284003171 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 697284003172 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 697284003173 NAD(P) binding site [chemical binding]; other site 697284003174 Protease prsW family; Region: PrsW-protease; pfam13367 697284003175 germination protein YpeB; Region: spore_YpeB; TIGR02889 697284003176 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284003177 MULE transposase domain; Region: MULE; pfam10551 697284003178 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284003179 MULE transposase domain; Region: MULE; pfam10551 697284003180 PilZ domain; Region: PilZ; pfam07238 697284003181 cytidylate kinase; Provisional; Region: cmk; PRK00023 697284003182 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 697284003183 CMP-binding site; other site 697284003184 The sites determining sugar specificity; other site 697284003185 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 697284003186 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 697284003187 putative acyl-acceptor binding pocket; other site 697284003188 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 697284003189 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 697284003190 RNA binding site [nucleotide binding]; other site 697284003191 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 697284003192 RNA binding site [nucleotide binding]; other site 697284003193 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 697284003194 RNA binding site [nucleotide binding]; other site 697284003195 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 697284003196 RNA binding site [nucleotide binding]; other site 697284003197 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 697284003198 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 697284003199 homotetramer interface [polypeptide binding]; other site 697284003200 FMN binding site [chemical binding]; other site 697284003201 homodimer contacts [polypeptide binding]; other site 697284003202 putative active site [active] 697284003203 putative substrate binding site [chemical binding]; other site 697284003204 YIEGIA protein; Region: YIEGIA; pfam14045 697284003205 GTP-binding protein Der; Reviewed; Region: PRK00093 697284003206 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 697284003207 G1 box; other site 697284003208 GTP/Mg2+ binding site [chemical binding]; other site 697284003209 Switch I region; other site 697284003210 G2 box; other site 697284003211 Switch II region; other site 697284003212 G3 box; other site 697284003213 G4 box; other site 697284003214 G5 box; other site 697284003215 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 697284003216 G1 box; other site 697284003217 GTP/Mg2+ binding site [chemical binding]; other site 697284003218 Switch I region; other site 697284003219 G2 box; other site 697284003220 G3 box; other site 697284003221 Switch II region; other site 697284003222 G4 box; other site 697284003223 G5 box; other site 697284003224 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 697284003225 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 697284003226 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 697284003227 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 697284003228 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 697284003229 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 697284003230 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 697284003231 catalytic loop [active] 697284003232 iron binding site [ion binding]; other site 697284003233 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 697284003234 metal binding triad [ion binding]; metal-binding site 697284003235 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 697284003236 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 697284003237 catalytic loop [active] 697284003238 iron binding site [ion binding]; other site 697284003239 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 697284003240 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 697284003241 G1 box; other site 697284003242 GTP/Mg2+ binding site [chemical binding]; other site 697284003243 G2 box; other site 697284003244 Switch I region; other site 697284003245 G3 box; other site 697284003246 Switch II region; other site 697284003247 G4 box; other site 697284003248 G5 box; other site 697284003249 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 697284003250 IHF - DNA interface [nucleotide binding]; other site 697284003251 IHF dimer interface [polypeptide binding]; other site 697284003252 transcription attenuation protein MtrB; Provisional; Region: PRK13251 697284003253 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 697284003254 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 697284003255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284003256 S-adenosylmethionine binding site [chemical binding]; other site 697284003257 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 697284003258 UbiA prenyltransferase family; Region: UbiA; pfam01040 697284003259 Flavoprotein; Region: Flavoprotein; pfam02441 697284003260 aromatic acid decarboxylase; Validated; Region: PRK05920 697284003261 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 697284003262 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 697284003263 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 697284003264 substrate binding pocket [chemical binding]; other site 697284003265 chain length determination region; other site 697284003266 substrate-Mg2+ binding site; other site 697284003267 catalytic residues [active] 697284003268 aspartate-rich region 1; other site 697284003269 active site lid residues [active] 697284003270 aspartate-rich region 2; other site 697284003271 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284003272 MULE transposase domain; Region: MULE; pfam10551 697284003273 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 697284003274 active site 697284003275 multimer interface [polypeptide binding]; other site 697284003276 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 697284003277 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 697284003278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284003279 S-adenosylmethionine binding site [chemical binding]; other site 697284003280 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 697284003281 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 697284003282 Tetramer interface [polypeptide binding]; other site 697284003283 active site 697284003284 FMN-binding site [chemical binding]; other site 697284003285 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 697284003286 active site 697284003287 dimer interface [polypeptide binding]; other site 697284003288 metal binding site [ion binding]; metal-binding site 697284003289 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 697284003290 homotrimer interaction site [polypeptide binding]; other site 697284003291 active site 697284003292 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 697284003293 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 697284003294 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 697284003295 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 697284003296 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 697284003297 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 697284003298 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 697284003299 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 697284003300 active site 697284003301 ribulose/triose binding site [chemical binding]; other site 697284003302 phosphate binding site [ion binding]; other site 697284003303 substrate (anthranilate) binding pocket [chemical binding]; other site 697284003304 product (indole) binding pocket [chemical binding]; other site 697284003305 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 697284003306 active site 697284003307 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 697284003308 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 697284003309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284003310 catalytic residue [active] 697284003311 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 697284003312 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 697284003313 substrate binding site [chemical binding]; other site 697284003314 active site 697284003315 catalytic residues [active] 697284003316 heterodimer interface [polypeptide binding]; other site 697284003317 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 697284003318 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 697284003319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284003320 homodimer interface [polypeptide binding]; other site 697284003321 catalytic residue [active] 697284003322 prephenate dehydrogenase; Validated; Region: PRK08507 697284003323 prephenate dehydrogenase; Validated; Region: PRK06545 697284003324 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 697284003325 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 697284003326 catalytic core [active] 697284003327 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 697284003328 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 697284003329 trimer interface [polypeptide binding]; other site 697284003330 putative metal binding site [ion binding]; other site 697284003331 A short protein domain of unknown function; Region: IDEAL; smart00914 697284003332 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 697284003333 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 697284003334 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284003335 MULE transposase domain; Region: MULE; pfam10551 697284003336 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 697284003337 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 697284003338 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 697284003339 iron-sulfur cluster [ion binding]; other site 697284003340 [2Fe-2S] cluster binding site [ion binding]; other site 697284003341 cytochrome b6; Provisional; Region: PRK03735 697284003342 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 697284003343 interchain domain interface [polypeptide binding]; other site 697284003344 intrachain domain interface; other site 697284003345 heme bH binding site [chemical binding]; other site 697284003346 Qi binding site; other site 697284003347 heme bL binding site [chemical binding]; other site 697284003348 Qo binding site; other site 697284003349 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 697284003350 intrachain domain interface; other site 697284003351 Qo binding site; other site 697284003352 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 697284003353 Cytochrome c; Region: Cytochrom_C; pfam00034 697284003354 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 697284003355 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 697284003356 Uncharacterized conserved protein [Function unknown]; Region: COG1284 697284003357 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 697284003358 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 697284003359 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 697284003360 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 697284003361 homodimer interface [polypeptide binding]; other site 697284003362 metal binding site [ion binding]; metal-binding site 697284003363 Tetratricopeptide repeat; Region: TPR_16; pfam13432 697284003364 TPR repeat; Region: TPR_11; pfam13414 697284003365 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 697284003366 binding surface 697284003367 TPR motif; other site 697284003368 dihydrodipicolinate reductase; Provisional; Region: PRK00048 697284003369 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 697284003370 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 697284003371 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 697284003372 active site 697284003373 dimer interfaces [polypeptide binding]; other site 697284003374 catalytic residues [active] 697284003375 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 697284003376 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 697284003377 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 697284003378 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 697284003379 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 697284003380 active site 697284003381 NTP binding site [chemical binding]; other site 697284003382 metal binding triad [ion binding]; metal-binding site 697284003383 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 697284003384 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 697284003385 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697284003386 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 697284003387 putative DNA binding site [nucleotide binding]; other site 697284003388 putative Zn2+ binding site [ion binding]; other site 697284003389 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 697284003390 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 697284003391 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 697284003392 oligomerization interface [polypeptide binding]; other site 697284003393 active site 697284003394 metal binding site [ion binding]; metal-binding site 697284003395 pantoate--beta-alanine ligase; Region: panC; TIGR00018 697284003396 Pantoate-beta-alanine ligase; Region: PanC; cd00560 697284003397 active site 697284003398 ATP-binding site [chemical binding]; other site 697284003399 pantoate-binding site; other site 697284003400 HXXH motif; other site 697284003401 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 697284003402 tetramerization interface [polypeptide binding]; other site 697284003403 active site 697284003404 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 697284003405 binding surface 697284003406 TPR motif; other site 697284003407 Tetratricopeptide repeat; Region: TPR_12; pfam13424 697284003408 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 697284003409 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 697284003410 active site 697284003411 catalytic site [active] 697284003412 substrate binding site [chemical binding]; other site 697284003413 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697284003414 ATP binding site [chemical binding]; other site 697284003415 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697284003416 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 697284003417 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 697284003418 CoA binding domain; Region: CoA_binding; pfam02629 697284003419 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 697284003420 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 697284003421 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 697284003422 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 697284003423 active site 697284003424 putative substrate binding pocket [chemical binding]; other site 697284003425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 697284003426 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 697284003427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697284003428 Walker A motif; other site 697284003429 ATP binding site [chemical binding]; other site 697284003430 Walker B motif; other site 697284003431 arginine finger; other site 697284003432 Peptidase family M41; Region: Peptidase_M41; pfam01434 697284003433 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 697284003434 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 697284003435 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 697284003436 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 697284003437 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 697284003438 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 697284003439 putative dimer interface [polypeptide binding]; other site 697284003440 putative anticodon binding site; other site 697284003441 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 697284003442 homodimer interface [polypeptide binding]; other site 697284003443 motif 1; other site 697284003444 motif 2; other site 697284003445 active site 697284003446 motif 3; other site 697284003447 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 697284003448 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 697284003449 synthetase active site [active] 697284003450 NTP binding site [chemical binding]; other site 697284003451 metal binding site [ion binding]; metal-binding site 697284003452 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284003453 MULE transposase domain; Region: MULE; pfam10551 697284003454 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 697284003455 intersubunit interface [polypeptide binding]; other site 697284003456 active site 697284003457 Zn2+ binding site [ion binding]; other site 697284003458 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 697284003459 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 697284003460 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 697284003461 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 697284003462 dimer interface [polypeptide binding]; other site 697284003463 active site 697284003464 catalytic residue [active] 697284003465 metal binding site [ion binding]; metal-binding site 697284003466 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 697284003467 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 697284003468 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 697284003469 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 697284003470 putative catalytic cysteine [active] 697284003471 gamma-glutamyl kinase; Provisional; Region: PRK05429 697284003472 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 697284003473 nucleotide binding site [chemical binding]; other site 697284003474 homotetrameric interface [polypeptide binding]; other site 697284003475 putative phosphate binding site [ion binding]; other site 697284003476 putative allosteric binding site; other site 697284003477 PUA domain; Region: PUA; pfam01472 697284003478 Predicted amidohydrolase [General function prediction only]; Region: COG0388 697284003479 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 697284003480 putative active site [active] 697284003481 catalytic triad [active] 697284003482 putative dimer interface [polypeptide binding]; other site 697284003483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 697284003484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284003485 Response regulator receiver domain; Region: Response_reg; pfam00072 697284003486 active site 697284003487 phosphorylation site [posttranslational modification] 697284003488 intermolecular recognition site; other site 697284003489 dimerization interface [polypeptide binding]; other site 697284003490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284003491 active site 697284003492 dimerization interface [polypeptide binding]; other site 697284003493 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697284003494 dimer interface [polypeptide binding]; other site 697284003495 phosphorylation site [posttranslational modification] 697284003496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284003497 ATP binding site [chemical binding]; other site 697284003498 Mg2+ binding site [ion binding]; other site 697284003499 G-X-G motif; other site 697284003500 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 697284003501 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 697284003502 anti sigma factor interaction site; other site 697284003503 regulatory phosphorylation site [posttranslational modification]; other site 697284003504 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 697284003505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284003506 ATP binding site [chemical binding]; other site 697284003507 Mg2+ binding site [ion binding]; other site 697284003508 G-X-G motif; other site 697284003509 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 697284003510 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697284003511 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 697284003512 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697284003513 DNA binding residues [nucleotide binding] 697284003514 Transcriptional regulator [Transcription]; Region: LysR; COG0583 697284003515 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 697284003516 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 697284003517 dimerization interface [polypeptide binding]; other site 697284003518 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 697284003519 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 697284003520 substrate binding site [chemical binding]; other site 697284003521 ligand binding site [chemical binding]; other site 697284003522 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 697284003523 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 697284003524 substrate binding site [chemical binding]; other site 697284003525 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 697284003526 AMIN domain; Region: AMIN; pfam11741 697284003527 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 697284003528 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 697284003529 active site 697284003530 metal binding site [ion binding]; metal-binding site 697284003531 Sporulation and spore germination; Region: Germane; pfam10646 697284003532 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 697284003533 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 697284003534 minor groove reading motif; other site 697284003535 helix-hairpin-helix signature motif; other site 697284003536 substrate binding pocket [chemical binding]; other site 697284003537 active site 697284003538 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 697284003539 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 697284003540 Dynamin family; Region: Dynamin_N; pfam00350 697284003541 G1 box; other site 697284003542 GTP/Mg2+ binding site [chemical binding]; other site 697284003543 G2 box; other site 697284003544 Switch I region; other site 697284003545 G3 box; other site 697284003546 Switch II region; other site 697284003547 G4 box; other site 697284003548 G5 box; other site 697284003549 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 697284003550 Dynamin family; Region: Dynamin_N; pfam00350 697284003551 G1 box; other site 697284003552 GTP/Mg2+ binding site [chemical binding]; other site 697284003553 G2 box; other site 697284003554 Switch I region; other site 697284003555 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 697284003556 G3 box; other site 697284003557 Switch II region; other site 697284003558 GTP/Mg2+ binding site [chemical binding]; other site 697284003559 G4 box; other site 697284003560 G5 box; other site 697284003561 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 697284003562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284003563 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 697284003564 active site 697284003565 catalytic triad [active] 697284003566 oxyanion hole [active] 697284003567 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 697284003568 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 697284003569 Walker A/P-loop; other site 697284003570 ATP binding site [chemical binding]; other site 697284003571 Q-loop/lid; other site 697284003572 ABC transporter signature motif; other site 697284003573 Walker B; other site 697284003574 D-loop; other site 697284003575 H-loop/switch region; other site 697284003576 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 697284003577 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 697284003578 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 697284003579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284003580 Mg2+ binding site [ion binding]; other site 697284003581 G-X-G motif; other site 697284003582 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 697284003583 anchoring element; other site 697284003584 dimer interface [polypeptide binding]; other site 697284003585 ATP binding site [chemical binding]; other site 697284003586 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 697284003587 active site 697284003588 putative metal-binding site [ion binding]; other site 697284003589 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 697284003590 DNA gyrase subunit A; Validated; Region: PRK05560 697284003591 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 697284003592 CAP-like domain; other site 697284003593 active site 697284003594 primary dimer interface [polypeptide binding]; other site 697284003595 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697284003596 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697284003597 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697284003598 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697284003599 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 697284003600 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 697284003601 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697284003602 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697284003603 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 697284003604 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 697284003605 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 697284003606 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284003607 MULE transposase domain; Region: MULE; pfam10551 697284003608 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 697284003609 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 697284003610 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 697284003611 active site 697284003612 catalytic tetrad [active] 697284003613 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 697284003614 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 697284003615 ABC transporter; Region: ABC_tran; pfam00005 697284003616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284003617 Q-loop/lid; other site 697284003618 ABC transporter signature motif; other site 697284003619 Walker B; other site 697284003620 D-loop; other site 697284003621 H-loop/switch region; other site 697284003622 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 697284003623 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 697284003624 Walker A/P-loop; other site 697284003625 ATP binding site [chemical binding]; other site 697284003626 Q-loop/lid; other site 697284003627 ABC transporter signature motif; other site 697284003628 Walker B; other site 697284003629 D-loop; other site 697284003630 H-loop/switch region; other site 697284003631 Predicted transcriptional regulators [Transcription]; Region: COG1725 697284003632 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697284003633 DNA-binding site [nucleotide binding]; DNA binding site 697284003634 aspartate aminotransferase; Provisional; Region: PRK09275 697284003635 Double zinc ribbon; Region: DZR; pfam12773 697284003636 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284003637 MULE transposase domain; Region: MULE; pfam10551 697284003638 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 697284003639 Putative glucoamylase; Region: Glycoamylase; pfam10091 697284003640 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 697284003641 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 697284003642 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 697284003643 MULE transposase domain; Region: MULE; pfam10551 697284003644 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284003645 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284003646 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284003647 MULE transposase domain; Region: MULE; pfam10551 697284003648 Transcriptional regulators [Transcription]; Region: MarR; COG1846 697284003649 MarR family; Region: MarR; pfam01047 697284003650 MarR family; Region: MarR_2; cl17246 697284003651 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 697284003652 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 697284003653 active site 697284003654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284003655 S-adenosylmethionine binding site [chemical binding]; other site 697284003656 glycogen branching enzyme; Provisional; Region: PRK12313 697284003657 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 697284003658 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 697284003659 active site 697284003660 catalytic site [active] 697284003661 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 697284003662 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 697284003663 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 697284003664 ligand binding site; other site 697284003665 oligomer interface; other site 697284003666 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 697284003667 dimer interface [polypeptide binding]; other site 697284003668 N-terminal domain interface [polypeptide binding]; other site 697284003669 sulfate 1 binding site; other site 697284003670 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 697284003671 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 697284003672 ligand binding site; other site 697284003673 oligomer interface; other site 697284003674 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 697284003675 dimer interface [polypeptide binding]; other site 697284003676 N-terminal domain interface [polypeptide binding]; other site 697284003677 sulfate 1 binding site; other site 697284003678 glycogen synthase; Provisional; Region: glgA; PRK00654 697284003679 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 697284003680 ADP-binding pocket [chemical binding]; other site 697284003681 homodimer interface [polypeptide binding]; other site 697284003682 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 697284003683 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284003684 MULE transposase domain; Region: MULE; pfam10551 697284003685 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284003686 MULE transposase domain; Region: MULE; pfam10551 697284003687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 697284003688 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 697284003689 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284003690 MULE transposase domain; Region: MULE; pfam10551 697284003691 arginine deiminase; Provisional; Region: PRK01388 697284003692 ornithine carbamoyltransferase; Validated; Region: PRK02102 697284003693 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 697284003694 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 697284003695 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 697284003696 carbamate kinase; Reviewed; Region: PRK12686 697284003697 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 697284003698 putative substrate binding site [chemical binding]; other site 697284003699 nucleotide binding site [chemical binding]; other site 697284003700 nucleotide binding site [chemical binding]; other site 697284003701 homodimer interface [polypeptide binding]; other site 697284003702 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 697284003703 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 697284003704 ligand binding site [chemical binding]; other site 697284003705 flexible hinge region; other site 697284003706 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 697284003707 putative switch regulator; other site 697284003708 non-specific DNA interactions [nucleotide binding]; other site 697284003709 DNA binding site [nucleotide binding] 697284003710 sequence specific DNA binding site [nucleotide binding]; other site 697284003711 putative cAMP binding site [chemical binding]; other site 697284003712 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 697284003713 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 697284003714 ligand binding site [chemical binding]; other site 697284003715 flexible hinge region; other site 697284003716 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 697284003717 non-specific DNA interactions [nucleotide binding]; other site 697284003718 DNA binding site [nucleotide binding] 697284003719 sequence specific DNA binding site [nucleotide binding]; other site 697284003720 putative cAMP binding site [chemical binding]; other site 697284003721 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 697284003722 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 697284003723 Protein of unknown function (DUF464); Region: DUF464; pfam04327 697284003724 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 697284003725 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 697284003726 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 697284003727 dinuclear metal binding motif [ion binding]; other site 697284003728 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 697284003729 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697284003730 Walker A/P-loop; other site 697284003731 ATP binding site [chemical binding]; other site 697284003732 Q-loop/lid; other site 697284003733 ABC transporter signature motif; other site 697284003734 Walker B; other site 697284003735 D-loop; other site 697284003736 H-loop/switch region; other site 697284003737 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 697284003738 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697284003739 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697284003740 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 697284003741 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 697284003742 intersubunit interface [polypeptide binding]; other site 697284003743 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 697284003744 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 697284003745 intersubunit interface [polypeptide binding]; other site 697284003746 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 697284003747 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 697284003748 ABC-ATPase subunit interface; other site 697284003749 dimer interface [polypeptide binding]; other site 697284003750 putative PBP binding regions; other site 697284003751 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 697284003752 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 697284003753 ABC-ATPase subunit interface; other site 697284003754 dimer interface [polypeptide binding]; other site 697284003755 putative PBP binding regions; other site 697284003756 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284003757 MULE transposase domain; Region: MULE; pfam10551 697284003758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 697284003759 Chitin binding domain; Region: Chitin_bind_3; pfam03067 697284003760 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 697284003761 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 697284003762 Interdomain contacts; other site 697284003763 Cytokine receptor motif; other site 697284003764 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 697284003765 aromatic chitin/cellulose binding site residues [chemical binding]; other site 697284003766 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 697284003767 aromatic chitin/cellulose binding site residues [chemical binding]; other site 697284003768 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697284003769 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284003770 non-specific DNA binding site [nucleotide binding]; other site 697284003771 salt bridge; other site 697284003772 sequence-specific DNA binding site [nucleotide binding]; other site 697284003773 Tetratricopeptide repeat; Region: TPR_16; pfam13432 697284003774 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 697284003775 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 697284003776 Cytochrome P450; Region: p450; cl12078 697284003777 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 697284003778 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 697284003779 putative active site [active] 697284003780 putative metal-binding site [ion binding]; other site 697284003781 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 697284003782 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 697284003783 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 697284003784 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 697284003785 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 697284003786 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284003787 MULE transposase domain; Region: MULE; pfam10551 697284003788 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 697284003789 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 697284003790 catalytic residues [active] 697284003791 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 697284003792 putative active cleft [active] 697284003793 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 697284003794 HTH-like domain; Region: HTH_21; pfam13276 697284003795 Integrase core domain; Region: rve; pfam00665 697284003796 Integrase core domain; Region: rve_2; pfam13333 697284003797 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284003798 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284003799 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284003800 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 697284003801 Predicted membrane protein [Function unknown]; Region: COG2860 697284003802 UPF0126 domain; Region: UPF0126; pfam03458 697284003803 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 697284003804 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 697284003805 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 697284003806 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 697284003807 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 697284003808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284003809 dimer interface [polypeptide binding]; other site 697284003810 conserved gate region; other site 697284003811 putative PBP binding loops; other site 697284003812 ABC-ATPase subunit interface; other site 697284003813 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 697284003814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284003815 dimer interface [polypeptide binding]; other site 697284003816 conserved gate region; other site 697284003817 putative PBP binding loops; other site 697284003818 ABC-ATPase subunit interface; other site 697284003819 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 697284003820 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 697284003821 Walker A/P-loop; other site 697284003822 ATP binding site [chemical binding]; other site 697284003823 Q-loop/lid; other site 697284003824 ABC transporter signature motif; other site 697284003825 Walker B; other site 697284003826 D-loop; other site 697284003827 H-loop/switch region; other site 697284003828 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 697284003829 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 697284003830 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697284003831 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 697284003832 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 697284003833 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 697284003834 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 697284003835 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 697284003836 Ligand binding site [chemical binding]; other site 697284003837 Electron transfer flavoprotein domain; Region: ETF; pfam01012 697284003838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 697284003839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 697284003840 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 697284003841 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 697284003842 4Fe-4S binding domain; Region: Fer4; cl02805 697284003843 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 697284003844 Cysteine-rich domain; Region: CCG; pfam02754 697284003845 Cysteine-rich domain; Region: CCG; pfam02754 697284003846 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 697284003847 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 697284003848 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 697284003849 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 697284003850 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 697284003851 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 697284003852 substrate binding site [chemical binding]; other site 697284003853 oxyanion hole (OAH) forming residues; other site 697284003854 trimer interface [polypeptide binding]; other site 697284003855 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 697284003856 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 697284003857 dimer interface [polypeptide binding]; other site 697284003858 active site 697284003859 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 697284003860 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 697284003861 active site 697284003862 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 697284003863 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 697284003864 acyl-activating enzyme (AAE) consensus motif; other site 697284003865 putative AMP binding site [chemical binding]; other site 697284003866 putative active site [active] 697284003867 putative CoA binding site [chemical binding]; other site 697284003868 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 697284003869 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 697284003870 CoenzymeA binding site [chemical binding]; other site 697284003871 subunit interaction site [polypeptide binding]; other site 697284003872 PHB binding site; other site 697284003873 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 697284003874 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 697284003875 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 697284003876 Walker A/P-loop; other site 697284003877 ATP binding site [chemical binding]; other site 697284003878 Q-loop/lid; other site 697284003879 ABC transporter signature motif; other site 697284003880 Walker B; other site 697284003881 D-loop; other site 697284003882 H-loop/switch region; other site 697284003883 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 697284003884 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 697284003885 substrate binding pocket [chemical binding]; other site 697284003886 membrane-bound complex binding site; other site 697284003887 hinge residues; other site 697284003888 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 697284003889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284003890 dimer interface [polypeptide binding]; other site 697284003891 conserved gate region; other site 697284003892 putative PBP binding loops; other site 697284003893 ABC-ATPase subunit interface; other site 697284003894 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 697284003895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284003896 dimer interface [polypeptide binding]; other site 697284003897 conserved gate region; other site 697284003898 putative PBP binding loops; other site 697284003899 ABC-ATPase subunit interface; other site 697284003900 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 697284003901 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 697284003902 metal binding site [ion binding]; metal-binding site 697284003903 Haemolysin-III related; Region: HlyIII; cl03831 697284003904 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 697284003905 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 697284003906 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 697284003907 substrate binding pocket [chemical binding]; other site 697284003908 membrane-bound complex binding site; other site 697284003909 hinge residues; other site 697284003910 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 697284003911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284003912 dimer interface [polypeptide binding]; other site 697284003913 conserved gate region; other site 697284003914 ABC-ATPase subunit interface; other site 697284003915 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 697284003916 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 697284003917 Walker A/P-loop; other site 697284003918 ATP binding site [chemical binding]; other site 697284003919 Q-loop/lid; other site 697284003920 ABC transporter signature motif; other site 697284003921 Walker B; other site 697284003922 D-loop; other site 697284003923 H-loop/switch region; other site 697284003924 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 697284003925 EDD domain protein, DegV family; Region: DegV; TIGR00762 697284003926 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 697284003927 EDD domain protein, DegV family; Region: DegV; TIGR00762 697284003928 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 697284003929 Mga helix-turn-helix domain; Region: Mga; pfam05043 697284003930 PRD domain; Region: PRD; pfam00874 697284003931 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 697284003932 active site 697284003933 phosphorylation site [posttranslational modification] 697284003934 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 697284003935 active site 697284003936 P-loop; other site 697284003937 phosphorylation site [posttranslational modification] 697284003938 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 697284003939 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 697284003940 active site 697284003941 metal binding site [ion binding]; metal-binding site 697284003942 homotetramer interface [polypeptide binding]; other site 697284003943 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 697284003944 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284003945 MULE transposase domain; Region: MULE; pfam10551 697284003946 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 697284003947 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 697284003948 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 697284003949 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 697284003950 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 697284003951 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 697284003952 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284003953 MULE transposase domain; Region: MULE; pfam10551 697284003954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697284003955 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 697284003956 NAD(P) binding site [chemical binding]; other site 697284003957 active site 697284003958 isochorismate synthase DhbC; Validated; Region: PRK06923 697284003959 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 697284003960 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 697284003961 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 697284003962 acyl-activating enzyme (AAE) consensus motif; other site 697284003963 active site 697284003964 AMP binding site [chemical binding]; other site 697284003965 substrate binding site [chemical binding]; other site 697284003966 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 697284003967 Isochorismatase family; Region: Isochorismatase; pfam00857 697284003968 catalytic triad [active] 697284003969 conserved cis-peptide bond; other site 697284003970 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 697284003971 Condensation domain; Region: Condensation; pfam00668 697284003972 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284003973 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 697284003974 acyl-activating enzyme (AAE) consensus motif; other site 697284003975 AMP binding site [chemical binding]; other site 697284003976 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284003977 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 697284003978 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 697284003979 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284003980 acyl-activating enzyme (AAE) consensus motif; other site 697284003981 AMP binding site [chemical binding]; other site 697284003982 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284003983 MbtH-like protein; Region: MbtH; pfam03621 697284003984 DNA topoisomerase III; Provisional; Region: PRK07726 697284003985 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 697284003986 active site 697284003987 putative interdomain interaction site [polypeptide binding]; other site 697284003988 putative metal-binding site [ion binding]; other site 697284003989 putative nucleotide binding site [chemical binding]; other site 697284003990 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 697284003991 domain I; other site 697284003992 DNA binding groove [nucleotide binding] 697284003993 phosphate binding site [ion binding]; other site 697284003994 domain II; other site 697284003995 domain III; other site 697284003996 nucleotide binding site [chemical binding]; other site 697284003997 catalytic site [active] 697284003998 domain IV; other site 697284003999 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 697284004000 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 697284004001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284004002 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 697284004003 ATP binding site [chemical binding]; other site 697284004004 G-X-G motif; other site 697284004005 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 697284004006 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 697284004007 nucleotide binding site [chemical binding]; other site 697284004008 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004009 MULE transposase domain; Region: MULE; pfam10551 697284004010 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 697284004011 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 697284004012 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 697284004013 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 697284004014 Major Facilitator Superfamily; Region: MFS_1; pfam07690 697284004015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284004016 putative substrate translocation pore; other site 697284004017 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 697284004018 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 697284004019 ATP-binding site [chemical binding]; other site 697284004020 Sugar specificity; other site 697284004021 Pyrimidine base specificity; other site 697284004022 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 697284004023 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 697284004024 active site 697284004025 nucleophile elbow; other site 697284004026 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 697284004027 NMT1/THI5 like; Region: NMT1; pfam09084 697284004028 Domain of unknown function DUF77; Region: DUF77; pfam01910 697284004029 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 697284004030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284004031 dimer interface [polypeptide binding]; other site 697284004032 conserved gate region; other site 697284004033 putative PBP binding loops; other site 697284004034 ABC-ATPase subunit interface; other site 697284004035 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 697284004036 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 697284004037 Walker A/P-loop; other site 697284004038 ATP binding site [chemical binding]; other site 697284004039 Q-loop/lid; other site 697284004040 ABC transporter signature motif; other site 697284004041 Walker B; other site 697284004042 D-loop; other site 697284004043 H-loop/switch region; other site 697284004044 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 697284004045 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 697284004046 active site 697284004047 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 697284004048 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 697284004049 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 697284004050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284004051 dimer interface [polypeptide binding]; other site 697284004052 conserved gate region; other site 697284004053 ABC-ATPase subunit interface; other site 697284004054 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 697284004055 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 697284004056 Walker A/P-loop; other site 697284004057 ATP binding site [chemical binding]; other site 697284004058 Q-loop/lid; other site 697284004059 ABC transporter signature motif; other site 697284004060 Walker B; other site 697284004061 D-loop; other site 697284004062 H-loop/switch region; other site 697284004063 NIL domain; Region: NIL; pfam09383 697284004064 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 697284004065 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 697284004066 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 697284004067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697284004068 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 697284004069 Coenzyme A binding pocket [chemical binding]; other site 697284004070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284004071 ABC transporter signature motif; other site 697284004072 Walker B; other site 697284004073 D-loop; other site 697284004074 H-loop/switch region; other site 697284004075 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 697284004076 YceI-like domain; Region: YceI; cl01001 697284004077 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 697284004078 catalytic residues [active] 697284004079 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 697284004080 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 697284004081 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 697284004082 Methyltransferase domain; Region: Methyltransf_11; pfam08241 697284004083 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 697284004084 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 697284004085 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 697284004086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697284004087 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 697284004088 active site 697284004089 motif I; other site 697284004090 motif II; other site 697284004091 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697284004092 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 697284004093 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 697284004094 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 697284004095 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 697284004096 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 697284004097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284004098 putative substrate translocation pore; other site 697284004099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284004100 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 697284004101 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284004102 non-specific DNA binding site [nucleotide binding]; other site 697284004103 salt bridge; other site 697284004104 sequence-specific DNA binding site [nucleotide binding]; other site 697284004105 Cupin domain; Region: Cupin_2; pfam07883 697284004106 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 697284004107 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 697284004108 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697284004109 catalytic residue [active] 697284004110 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 697284004111 DoxX-like family; Region: DoxX_3; pfam13781 697284004112 Sulfatase; Region: Sulfatase; cl17466 697284004113 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 697284004114 Spore germination protein; Region: Spore_permease; cl17796 697284004115 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 697284004116 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 697284004117 putative active site [active] 697284004118 PKD domain; Region: PKD; pfam00801 697284004119 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 697284004120 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 697284004121 sugar binding site [chemical binding]; other site 697284004122 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 697284004123 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 697284004124 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 697284004125 active site turn [active] 697284004126 phosphorylation site [posttranslational modification] 697284004127 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 697284004128 Predicted membrane protein [Function unknown]; Region: COG2707 697284004129 seryl-tRNA synthetase; Provisional; Region: PRK05431 697284004130 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 697284004131 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 697284004132 dimer interface [polypeptide binding]; other site 697284004133 active site 697284004134 motif 1; other site 697284004135 motif 2; other site 697284004136 motif 3; other site 697284004137 lysine transporter; Provisional; Region: PRK10836 697284004138 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 697284004139 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 697284004140 putative active site [active] 697284004141 putative metal binding site [ion binding]; other site 697284004142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284004143 Major Facilitator Superfamily; Region: MFS_1; pfam07690 697284004144 putative substrate translocation pore; other site 697284004145 Integral membrane protein DUF95; Region: DUF95; cl00572 697284004146 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 697284004147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284004148 Walker A/P-loop; other site 697284004149 ATP binding site [chemical binding]; other site 697284004150 Q-loop/lid; other site 697284004151 ABC transporter signature motif; other site 697284004152 Walker B; other site 697284004153 D-loop; other site 697284004154 H-loop/switch region; other site 697284004155 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004156 MULE transposase domain; Region: MULE; pfam10551 697284004157 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 697284004158 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697284004159 dimerization interface [polypeptide binding]; other site 697284004160 putative Zn2+ binding site [ion binding]; other site 697284004161 putative DNA binding site [nucleotide binding]; other site 697284004162 Predicted membrane protein [Function unknown]; Region: COG2364 697284004163 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 697284004164 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 697284004165 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 697284004166 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 697284004167 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 697284004168 Domain of unknown function DUF21; Region: DUF21; pfam01595 697284004169 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 697284004170 Transporter associated domain; Region: CorC_HlyC; pfam03471 697284004171 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 697284004172 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 697284004173 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 697284004174 putative active site [active] 697284004175 Thioredoxin; Region: Thioredoxin_4; cl17273 697284004176 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 697284004177 sugar phosphate phosphatase; Provisional; Region: PRK10513 697284004178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697284004179 active site 697284004180 motif I; other site 697284004181 motif II; other site 697284004182 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697284004183 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697284004184 Coenzyme A binding pocket [chemical binding]; other site 697284004185 HTH-like domain; Region: HTH_21; pfam13276 697284004186 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284004187 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284004188 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284004189 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284004190 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697284004191 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697284004192 DNA binding site [nucleotide binding] 697284004193 domain linker motif; other site 697284004194 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 697284004195 putative dimerization interface [polypeptide binding]; other site 697284004196 putative ligand binding site [chemical binding]; other site 697284004197 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 697284004198 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 697284004199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284004200 dimer interface [polypeptide binding]; other site 697284004201 conserved gate region; other site 697284004202 ABC-ATPase subunit interface; other site 697284004203 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 697284004204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284004205 dimer interface [polypeptide binding]; other site 697284004206 conserved gate region; other site 697284004207 putative PBP binding loops; other site 697284004208 ABC-ATPase subunit interface; other site 697284004209 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 697284004210 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 697284004211 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697284004212 Coenzyme A binding pocket [chemical binding]; other site 697284004213 Nitronate monooxygenase; Region: NMO; pfam03060 697284004214 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 697284004215 FMN binding site [chemical binding]; other site 697284004216 substrate binding site [chemical binding]; other site 697284004217 putative catalytic residue [active] 697284004218 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 697284004219 hydroxylamine reductase; Provisional; Region: PRK12310 697284004220 ACS interaction site; other site 697284004221 CODH interaction site; other site 697284004222 metal cluster binding site [ion binding]; other site 697284004223 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004224 MULE transposase domain; Region: MULE; pfam10551 697284004225 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 697284004226 FAD binding domain; Region: FAD_binding_4; pfam01565 697284004227 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 697284004228 Replication terminator protein; Region: RTP; pfam02334 697284004229 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 697284004230 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 697284004231 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 697284004232 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 697284004233 intersubunit interface [polypeptide binding]; other site 697284004234 active site 697284004235 zinc binding site [ion binding]; other site 697284004236 Na+ binding site [ion binding]; other site 697284004237 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 697284004238 active site 697284004239 P-loop; other site 697284004240 phosphorylation site [posttranslational modification] 697284004241 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 697284004242 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 697284004243 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 697284004244 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 697284004245 putative substrate binding site [chemical binding]; other site 697284004246 putative ATP binding site [chemical binding]; other site 697284004247 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 697284004248 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 697284004249 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 697284004250 putative active site [active] 697284004251 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004252 MULE transposase domain; Region: MULE; pfam10551 697284004253 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 697284004254 putative active site [active] 697284004255 nucleotide binding site [chemical binding]; other site 697284004256 nudix motif; other site 697284004257 putative metal binding site [ion binding]; other site 697284004258 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 697284004259 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 697284004260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 697284004261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 697284004262 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 697284004263 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 697284004264 Int/Topo IB signature motif; other site 697284004265 DNA binding site [nucleotide binding] 697284004266 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 697284004267 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004268 MULE transposase domain; Region: MULE; pfam10551 697284004269 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004270 MULE transposase domain; Region: MULE; pfam10551 697284004271 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 697284004272 substrate binding site [chemical binding]; other site 697284004273 amidase catalytic site [active] 697284004274 Zn binding residues [ion binding]; other site 697284004275 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 697284004276 putative metal binding site [ion binding]; other site 697284004277 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284004278 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284004279 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284004280 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 697284004281 HTH-like domain; Region: HTH_21; pfam13276 697284004282 Integrase core domain; Region: rve; pfam00665 697284004283 Integrase core domain; Region: rve_2; pfam13333 697284004284 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 697284004285 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 697284004286 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 697284004287 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 697284004288 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 697284004289 substrate binding pocket [chemical binding]; other site 697284004290 membrane-bound complex binding site; other site 697284004291 hinge residues; other site 697284004292 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 697284004293 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 697284004294 Walker A/P-loop; other site 697284004295 ATP binding site [chemical binding]; other site 697284004296 Q-loop/lid; other site 697284004297 ABC transporter signature motif; other site 697284004298 Walker B; other site 697284004299 D-loop; other site 697284004300 H-loop/switch region; other site 697284004301 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 697284004302 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 697284004303 oligomer interface [polypeptide binding]; other site 697284004304 active site 697284004305 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 697284004306 Phosphotransferase enzyme family; Region: APH; pfam01636 697284004307 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 697284004308 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 697284004309 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004310 MULE transposase domain; Region: MULE; pfam10551 697284004311 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 697284004312 Integrase core domain; Region: rve; pfam00665 697284004313 Integrase core domain; Region: rve_2; pfam13333 697284004314 HTH-like domain; Region: HTH_21; pfam13276 697284004315 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284004316 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284004317 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284004318 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 697284004319 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 697284004320 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 697284004321 GIY-YIG motif/motif A; other site 697284004322 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 697284004323 DNA binding residues [nucleotide binding] 697284004324 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 697284004325 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 697284004326 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 697284004327 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 697284004328 catalytic loop [active] 697284004329 iron binding site [ion binding]; other site 697284004330 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 697284004331 4Fe-4S binding domain; Region: Fer4; pfam00037 697284004332 4Fe-4S binding domain; Region: Fer4; pfam00037 697284004333 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 697284004334 [4Fe-4S] binding site [ion binding]; other site 697284004335 molybdopterin cofactor binding site; other site 697284004336 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 697284004337 molybdopterin cofactor binding site; other site 697284004338 Uncharacterized conserved protein [Function unknown]; Region: COG2427 697284004339 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 697284004340 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 697284004341 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 697284004342 ABC-ATPase subunit interface; other site 697284004343 dimer interface [polypeptide binding]; other site 697284004344 putative PBP binding regions; other site 697284004345 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 697284004346 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 697284004347 ABC-ATPase subunit interface; other site 697284004348 dimer interface [polypeptide binding]; other site 697284004349 putative PBP binding regions; other site 697284004350 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 697284004351 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 697284004352 Walker A/P-loop; other site 697284004353 ATP binding site [chemical binding]; other site 697284004354 Q-loop/lid; other site 697284004355 ABC transporter signature motif; other site 697284004356 Walker B; other site 697284004357 D-loop; other site 697284004358 H-loop/switch region; other site 697284004359 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 697284004360 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 697284004361 putative ligand binding residues [chemical binding]; other site 697284004362 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 697284004363 Transposase IS200 like; Region: Y1_Tnp; cl00848 697284004364 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 697284004365 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 697284004366 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 697284004367 catalytic core [active] 697284004368 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 697284004369 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 697284004370 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 697284004371 synthetase active site [active] 697284004372 NTP binding site [chemical binding]; other site 697284004373 metal binding site [ion binding]; metal-binding site 697284004374 Penicillinase repressor; Region: Pencillinase_R; pfam03965 697284004375 Peptidase family M48; Region: Peptidase_M48; cl12018 697284004376 Thioredoxin; Region: Thioredoxin_4; pfam13462 697284004377 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 697284004378 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 697284004379 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 697284004380 short chain dehydrogenase; Provisional; Region: PRK07041 697284004381 putative NAD(P) binding site [chemical binding]; other site 697284004382 homodimer interface [polypeptide binding]; other site 697284004383 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697284004384 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697284004385 DNA binding site [nucleotide binding] 697284004386 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 697284004387 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 697284004388 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 697284004389 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 697284004390 putative DNA binding site [nucleotide binding]; other site 697284004391 putative Zn2+ binding site [ion binding]; other site 697284004392 AsnC family; Region: AsnC_trans_reg; pfam01037 697284004393 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 697284004394 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 697284004395 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 697284004396 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 697284004397 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 697284004398 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 697284004399 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 697284004400 FemAB family; Region: FemAB; pfam02388 697284004401 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 697284004402 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004403 MULE transposase domain; Region: MULE; pfam10551 697284004404 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 697284004405 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 697284004406 active site 697284004407 dimer interface [polypeptide binding]; other site 697284004408 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004409 MULE transposase domain; Region: MULE; pfam10551 697284004410 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 697284004411 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 697284004412 Response regulator receiver domain; Region: Response_reg; pfam00072 697284004413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284004414 active site 697284004415 phosphorylation site [posttranslational modification] 697284004416 intermolecular recognition site; other site 697284004417 dimerization interface [polypeptide binding]; other site 697284004418 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697284004419 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 697284004420 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697284004421 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 697284004422 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697284004423 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284004424 non-specific DNA binding site [nucleotide binding]; other site 697284004425 salt bridge; other site 697284004426 sequence-specific DNA binding site [nucleotide binding]; other site 697284004427 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 697284004428 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 697284004429 Domain of unknown function DUF; Region: DUF204; pfam02659 697284004430 methionine sulfoxide reductase A; Provisional; Region: PRK14054 697284004431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697284004432 DNA-binding site [nucleotide binding]; DNA binding site 697284004433 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 697284004434 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 697284004435 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 697284004436 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 697284004437 active site turn [active] 697284004438 phosphorylation site [posttranslational modification] 697284004439 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 697284004440 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 697284004441 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 697284004442 Ca binding site [ion binding]; other site 697284004443 active site 697284004444 catalytic site [active] 697284004445 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 697284004446 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 697284004447 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004448 MULE transposase domain; Region: MULE; pfam10551 697284004449 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 697284004450 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 697284004451 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 697284004452 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 697284004453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697284004454 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 697284004455 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697284004456 DNA binding residues [nucleotide binding] 697284004457 short chain dehydrogenase; Provisional; Region: PRK06701 697284004458 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 697284004459 NAD binding site [chemical binding]; other site 697284004460 metal binding site [ion binding]; metal-binding site 697284004461 active site 697284004462 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 697284004463 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 697284004464 active site 697284004465 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 697284004466 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 697284004467 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 697284004468 active site 697284004469 Zn binding site [ion binding]; other site 697284004470 HTH-like domain; Region: HTH_21; pfam13276 697284004471 Integrase core domain; Region: rve; pfam00665 697284004472 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004473 MULE transposase domain; Region: MULE; pfam10551 697284004474 Spore germination protein GerPC; Region: GerPC; pfam10737 697284004475 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 697284004476 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 697284004477 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 697284004478 hypothetical protein; Provisional; Region: PRK08236 697284004479 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 697284004480 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 697284004481 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 697284004482 homodimer interface [polypeptide binding]; other site 697284004483 substrate-cofactor binding pocket; other site 697284004484 catalytic residue [active] 697284004485 Transcriptional regulator [Transcription]; Region: LysR; COG0583 697284004486 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 697284004487 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 697284004488 dimerization interface [polypeptide binding]; other site 697284004489 glutaminase A; Region: Gln_ase; TIGR03814 697284004490 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 697284004491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284004492 ATP binding site [chemical binding]; other site 697284004493 Mg2+ binding site [ion binding]; other site 697284004494 G-X-G motif; other site 697284004495 FCD domain; Region: FCD; pfam07729 697284004496 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004497 MULE transposase domain; Region: MULE; pfam10551 697284004498 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 697284004499 manganese transport protein MntH; Reviewed; Region: PRK00701 697284004500 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 697284004501 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004502 MULE transposase domain; Region: MULE; pfam10551 697284004503 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 697284004504 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 697284004505 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 697284004506 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 697284004507 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 697284004508 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 697284004509 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 697284004510 Condensation domain; Region: Condensation; pfam00668 697284004511 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284004512 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284004513 acyl-activating enzyme (AAE) consensus motif; other site 697284004514 AMP binding site [chemical binding]; other site 697284004515 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004516 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 697284004517 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 697284004518 active site 697284004519 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 697284004520 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 697284004521 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 697284004522 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 697284004523 putative NADP binding site [chemical binding]; other site 697284004524 active site 697284004525 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004526 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 697284004527 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 697284004528 active site 697284004529 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 697284004530 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 697284004531 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 697284004532 putative NADP binding site [chemical binding]; other site 697284004533 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 697284004534 active site 697284004535 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004536 Condensation domain; Region: Condensation; pfam00668 697284004537 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284004538 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 697284004539 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284004540 acyl-activating enzyme (AAE) consensus motif; other site 697284004541 AMP binding site [chemical binding]; other site 697284004542 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004543 Condensation domain; Region: Condensation; pfam00668 697284004544 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284004545 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 697284004546 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 697284004547 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 697284004548 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 697284004549 Methyltransferase domain; Region: Methyltransf_31; pfam13847 697284004550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284004551 S-adenosylmethionine binding site [chemical binding]; other site 697284004552 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284004553 acyl-activating enzyme (AAE) consensus motif; other site 697284004554 AMP binding site [chemical binding]; other site 697284004555 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004556 Condensation domain; Region: Condensation; pfam00668 697284004557 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284004558 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 697284004559 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284004560 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 697284004561 acyl-activating enzyme (AAE) consensus motif; other site 697284004562 AMP binding site [chemical binding]; other site 697284004563 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004564 Condensation domain; Region: Condensation; pfam00668 697284004565 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284004566 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 697284004567 Condensation domain; Region: Condensation; pfam00668 697284004568 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284004569 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284004570 acyl-activating enzyme (AAE) consensus motif; other site 697284004571 AMP binding site [chemical binding]; other site 697284004572 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004573 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 697284004574 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 697284004575 active site 697284004576 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 697284004577 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 697284004578 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 697284004579 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 697284004580 putative NADP binding site [chemical binding]; other site 697284004581 active site 697284004582 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004583 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 697284004584 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 697284004585 active site 697284004586 Acyl transferase domain; Region: Acyl_transf_1; cl08282 697284004587 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 697284004588 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 697284004589 putative NADP binding site [chemical binding]; other site 697284004590 active site 697284004591 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004592 Condensation domain; Region: Condensation; pfam00668 697284004593 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284004594 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 697284004595 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 697284004596 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 697284004597 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 697284004598 Methyltransferase domain; Region: Methyltransf_31; pfam13847 697284004599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284004600 S-adenosylmethionine binding site [chemical binding]; other site 697284004601 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284004602 acyl-activating enzyme (AAE) consensus motif; other site 697284004603 AMP binding site [chemical binding]; other site 697284004604 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004605 Condensation domain; Region: Condensation; pfam00668 697284004606 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284004607 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 697284004608 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284004609 acyl-activating enzyme (AAE) consensus motif; other site 697284004610 AMP binding site [chemical binding]; other site 697284004611 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004612 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 697284004613 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 697284004614 Beta-lactamase; Region: Beta-lactamase; pfam00144 697284004615 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 697284004616 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 697284004617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284004618 Walker A/P-loop; other site 697284004619 ATP binding site [chemical binding]; other site 697284004620 Q-loop/lid; other site 697284004621 ABC transporter signature motif; other site 697284004622 Walker B; other site 697284004623 D-loop; other site 697284004624 H-loop/switch region; other site 697284004625 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 697284004626 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 697284004627 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 697284004628 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 697284004629 Transcription antiterminator [Transcription]; Region: NusG; COG0250 697284004630 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 697284004631 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 697284004632 heterodimer interface [polypeptide binding]; other site 697284004633 homodimer interface [polypeptide binding]; other site 697284004634 Condensation domain; Region: Condensation; pfam00668 697284004635 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284004636 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 697284004637 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284004638 acyl-activating enzyme (AAE) consensus motif; other site 697284004639 AMP binding site [chemical binding]; other site 697284004640 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004641 Condensation domain; Region: Condensation; pfam00668 697284004642 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 697284004643 FkbH-like domain; Region: FkbH; TIGR01686 697284004644 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697284004645 active site 697284004646 motif I; other site 697284004647 motif II; other site 697284004648 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 697284004649 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 697284004650 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 697284004651 active site 697284004652 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 697284004653 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 697284004654 dimer interface [polypeptide binding]; other site 697284004655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284004656 catalytic residue [active] 697284004657 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 697284004658 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 697284004659 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 697284004660 ParB-like nuclease domain; Region: ParB; smart00470 697284004661 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 697284004662 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 697284004663 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 697284004664 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 697284004665 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 697284004666 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 697284004667 active site 697284004668 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 697284004669 dimer interface [polypeptide binding]; other site 697284004670 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 697284004671 Ligand Binding Site [chemical binding]; other site 697284004672 Molecular Tunnel; other site 697284004673 Transcriptional regulator [Transcription]; Region: LysR; COG0583 697284004674 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 697284004675 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 697284004676 dimerization interface [polypeptide binding]; other site 697284004677 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 697284004678 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 697284004679 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 697284004680 tetramer interface [polypeptide binding]; other site 697284004681 active site 697284004682 Mg2+/Mn2+ binding site [ion binding]; other site 697284004683 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 697284004684 PYR/PP interface [polypeptide binding]; other site 697284004685 dimer interface [polypeptide binding]; other site 697284004686 TPP binding site [chemical binding]; other site 697284004687 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 697284004688 TPP-binding site [chemical binding]; other site 697284004689 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004690 MULE transposase domain; Region: MULE; pfam10551 697284004691 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 697284004692 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 697284004693 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 697284004694 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 697284004695 nucleotide binding site [chemical binding]; other site 697284004696 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 697284004697 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 697284004698 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 697284004699 putative transport protein YifK; Provisional; Region: PRK10746 697284004700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284004701 Major Facilitator Superfamily; Region: MFS_1; pfam07690 697284004702 putative substrate translocation pore; other site 697284004703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 697284004704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 697284004705 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 697284004706 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 697284004707 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004708 MULE transposase domain; Region: MULE; pfam10551 697284004709 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 697284004710 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 697284004711 Amidinotransferase; Region: Amidinotransf; cl12043 697284004712 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 697284004713 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 697284004714 NAD(P) binding site [chemical binding]; other site 697284004715 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 697284004716 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 697284004717 Serine hydrolase; Region: Ser_hydrolase; cl17834 697284004718 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 697284004719 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 697284004720 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 697284004721 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 697284004722 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 697284004723 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 697284004724 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004725 MULE transposase domain; Region: MULE; pfam10551 697284004726 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697284004727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284004728 Walker A/P-loop; other site 697284004729 ATP binding site [chemical binding]; other site 697284004730 Q-loop/lid; other site 697284004731 ABC transporter signature motif; other site 697284004732 Walker B; other site 697284004733 D-loop; other site 697284004734 H-loop/switch region; other site 697284004735 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004736 MULE transposase domain; Region: MULE; pfam10551 697284004737 phosphoenolpyruvate synthase; Validated; Region: PRK06241 697284004738 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 697284004739 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 697284004740 HTH-like domain; Region: HTH_21; pfam13276 697284004741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 697284004742 Integrase core domain; Region: rve; pfam00665 697284004743 Integrase core domain; Region: rve_2; pfam13333 697284004744 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284004745 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284004746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284004747 Transposase; Region: HTH_Tnp_1; cl17663 697284004748 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284004749 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284004750 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 697284004751 acyl-activating enzyme (AAE) consensus motif; other site 697284004752 AMP binding site [chemical binding]; other site 697284004753 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004754 Condensation domain; Region: Condensation; pfam00668 697284004755 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284004756 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 697284004757 Condensation domain; Region: Condensation; pfam00668 697284004758 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284004759 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284004760 acyl-activating enzyme (AAE) consensus motif; other site 697284004761 AMP binding site [chemical binding]; other site 697284004762 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004763 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 697284004764 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284004765 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 697284004766 acyl-activating enzyme (AAE) consensus motif; other site 697284004767 AMP binding site [chemical binding]; other site 697284004768 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004769 Condensation domain; Region: Condensation; pfam00668 697284004770 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284004771 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 697284004772 Condensation domain; Region: Condensation; pfam00668 697284004773 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284004774 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284004775 acyl-activating enzyme (AAE) consensus motif; other site 697284004776 AMP binding site [chemical binding]; other site 697284004777 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004778 Condensation domain; Region: Condensation; pfam00668 697284004779 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284004780 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 697284004781 Condensation domain; Region: Condensation; pfam00668 697284004782 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284004783 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284004784 acyl-activating enzyme (AAE) consensus motif; other site 697284004785 AMP binding site [chemical binding]; other site 697284004786 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004787 Condensation domain; Region: Condensation; pfam00668 697284004788 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284004789 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 697284004790 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284004791 acyl-activating enzyme (AAE) consensus motif; other site 697284004792 AMP binding site [chemical binding]; other site 697284004793 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004794 Condensation domain; Region: Condensation; pfam00668 697284004795 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284004796 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 697284004797 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 697284004798 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 697284004799 acyl-activating enzyme (AAE) consensus motif; other site 697284004800 putative AMP binding site [chemical binding]; other site 697284004801 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004802 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 697284004803 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 697284004804 active site 697284004805 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004806 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 697284004807 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 697284004808 inhibitor-cofactor binding pocket; inhibition site 697284004809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284004810 catalytic residue [active] 697284004811 Condensation domain; Region: Condensation; pfam00668 697284004812 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284004813 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 697284004814 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004815 Condensation domain; Region: Condensation; pfam00668 697284004816 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284004817 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 697284004818 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284004819 acyl-activating enzyme (AAE) consensus motif; other site 697284004820 AMP binding site [chemical binding]; other site 697284004821 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284004822 Condensation domain; Region: Condensation; pfam00668 697284004823 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284004824 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 697284004825 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 697284004826 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 697284004827 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 697284004828 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 697284004829 dimer interface [polypeptide binding]; other site 697284004830 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 697284004831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 697284004832 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 697284004833 dimerization interface [polypeptide binding]; other site 697284004834 substrate binding pocket [chemical binding]; other site 697284004835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 697284004836 Homeodomain-like domain; Region: HTH_23; pfam13384 697284004837 Winged helix-turn helix; Region: HTH_33; pfam13592 697284004838 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697284004839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 697284004840 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004841 MULE transposase domain; Region: MULE; pfam10551 697284004842 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 697284004843 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 697284004844 Cation efflux family; Region: Cation_efflux; pfam01545 697284004845 Filamin/ABP280 repeat; Region: Filamin; pfam00630 697284004846 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 697284004847 catalytic core [active] 697284004848 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 697284004849 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 697284004850 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 697284004851 NodB motif; other site 697284004852 active site 697284004853 catalytic site [active] 697284004854 Cd binding site [ion binding]; other site 697284004855 stage V sporulation protein B; Region: spore_V_B; TIGR02900 697284004856 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 697284004857 Putative amidase domain; Region: Amidase_6; pfam12671 697284004858 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 697284004859 RNAase interaction site [polypeptide binding]; other site 697284004860 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 697284004861 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004862 MULE transposase domain; Region: MULE; pfam10551 697284004863 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 697284004864 ABC transporter signature motif; other site 697284004865 Walker B; other site 697284004866 D-loop; other site 697284004867 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 697284004868 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 697284004869 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 697284004870 active site residue [active] 697284004871 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 697284004872 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 697284004873 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 697284004874 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004875 MULE transposase domain; Region: MULE; pfam10551 697284004876 Transposase IS200 like; Region: Y1_Tnp; pfam01797 697284004877 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 697284004878 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 697284004879 Ligand binding site; other site 697284004880 metal-binding site 697284004881 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 697284004882 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 697284004883 substrate binding site; other site 697284004884 metal-binding site 697284004885 Oligomer interface; other site 697284004886 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 697284004887 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004888 MULE transposase domain; Region: MULE; pfam10551 697284004889 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 697284004890 Na+ binding site [ion binding]; other site 697284004891 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 697284004892 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 697284004893 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004894 MULE transposase domain; Region: MULE; pfam10551 697284004895 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004896 MULE transposase domain; Region: MULE; pfam10551 697284004897 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 697284004898 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 697284004899 putative active site cavity [active] 697284004900 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 697284004901 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 697284004902 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 697284004903 active site turn [active] 697284004904 phosphorylation site [posttranslational modification] 697284004905 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004906 MULE transposase domain; Region: MULE; pfam10551 697284004907 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 697284004908 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 697284004909 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 697284004910 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 697284004911 putative active site [active] 697284004912 putative metal binding site [ion binding]; other site 697284004913 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 697284004914 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 697284004915 N- and C-terminal domain interface [polypeptide binding]; other site 697284004916 active site 697284004917 catalytic site [active] 697284004918 metal binding site [ion binding]; metal-binding site 697284004919 carbohydrate binding site [chemical binding]; other site 697284004920 ATP binding site [chemical binding]; other site 697284004921 GntP family permease; Region: GntP_permease; pfam02447 697284004922 fructuronate transporter; Provisional; Region: PRK10034; cl15264 697284004923 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 697284004924 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697284004925 DNA-binding site [nucleotide binding]; DNA binding site 697284004926 FCD domain; Region: FCD; pfam07729 697284004927 Tic20-like protein; Region: Tic20; pfam09685 697284004928 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004929 MULE transposase domain; Region: MULE; pfam10551 697284004930 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 697284004931 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004932 MULE transposase domain; Region: MULE; pfam10551 697284004933 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697284004934 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 697284004935 Walker A/P-loop; other site 697284004936 ATP binding site [chemical binding]; other site 697284004937 Q-loop/lid; other site 697284004938 ABC transporter signature motif; other site 697284004939 Walker B; other site 697284004940 D-loop; other site 697284004941 H-loop/switch region; other site 697284004942 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004943 MULE transposase domain; Region: MULE; pfam10551 697284004944 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697284004945 Coenzyme A binding pocket [chemical binding]; other site 697284004946 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 697284004947 Cupin; Region: Cupin_1; smart00835 697284004948 Cupin; Region: Cupin_1; smart00835 697284004949 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 697284004950 DoxX; Region: DoxX; pfam07681 697284004951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284004952 Walker B; other site 697284004953 D-loop; other site 697284004954 H-loop/switch region; other site 697284004955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284004956 Q-loop/lid; other site 697284004957 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 697284004958 Walker A/P-loop; other site 697284004959 ATP binding site [chemical binding]; other site 697284004960 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004961 MULE transposase domain; Region: MULE; pfam10551 697284004962 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 697284004963 DNA binding site [nucleotide binding] 697284004964 Response regulator receiver domain; Region: Response_reg; pfam00072 697284004965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284004966 active site 697284004967 phosphorylation site [posttranslational modification] 697284004968 intermolecular recognition site; other site 697284004969 dimerization interface [polypeptide binding]; other site 697284004970 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 697284004971 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 697284004972 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004973 MULE transposase domain; Region: MULE; pfam10551 697284004974 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 697284004975 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 697284004976 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 697284004977 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 697284004978 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284004979 MULE transposase domain; Region: MULE; pfam10551 697284004980 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697284004981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284004982 active site 697284004983 phosphorylation site [posttranslational modification] 697284004984 intermolecular recognition site; other site 697284004985 dimerization interface [polypeptide binding]; other site 697284004986 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697284004987 DNA binding site [nucleotide binding] 697284004988 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 697284004989 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 697284004990 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 697284004991 MgtE intracellular N domain; Region: MgtE_N; pfam03448 697284004992 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 697284004993 Divalent cation transporter; Region: MgtE; pfam01769 697284004994 magnesium-transporting ATPase; Provisional; Region: PRK15122 697284004995 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 697284004996 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 697284004997 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 697284004998 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697284004999 motif II; other site 697284005000 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 697284005001 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 697284005002 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 697284005003 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 697284005004 THF binding site; other site 697284005005 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 697284005006 substrate binding site [chemical binding]; other site 697284005007 THF binding site; other site 697284005008 zinc-binding site [ion binding]; other site 697284005009 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 697284005010 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 697284005011 active site 697284005012 DNA binding site [nucleotide binding] 697284005013 Int/Topo IB signature motif; other site 697284005014 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 697284005015 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 697284005016 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 697284005017 Walker A/P-loop; other site 697284005018 ATP binding site [chemical binding]; other site 697284005019 Q-loop/lid; other site 697284005020 ABC transporter signature motif; other site 697284005021 Walker B; other site 697284005022 D-loop; other site 697284005023 H-loop/switch region; other site 697284005024 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 697284005025 HTH domain; Region: HTH_11; pfam08279 697284005026 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 697284005027 FOG: CBS domain [General function prediction only]; Region: COG0517 697284005028 pyruvate phosphate dikinase; Provisional; Region: PRK09279 697284005029 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 697284005030 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 697284005031 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 697284005032 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 697284005033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284005034 Major Facilitator Superfamily; Region: MFS_1; pfam07690 697284005035 putative substrate translocation pore; other site 697284005036 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 697284005037 Fumarase C-terminus; Region: Fumerase_C; pfam05683 697284005038 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 697284005039 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 697284005040 tetramer interface [polypeptide binding]; other site 697284005041 active site 697284005042 Mg2+/Mn2+ binding site [ion binding]; other site 697284005043 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 697284005044 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 697284005045 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 697284005046 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284005047 MULE transposase domain; Region: MULE; pfam10551 697284005048 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 697284005049 Low molecular weight phosphatase family; Region: LMWPc; cd00115 697284005050 active site 697284005051 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284005052 MULE transposase domain; Region: MULE; pfam10551 697284005053 Response regulator receiver domain; Region: Response_reg; pfam00072 697284005054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284005055 active site 697284005056 phosphorylation site [posttranslational modification] 697284005057 intermolecular recognition site; other site 697284005058 dimerization interface [polypeptide binding]; other site 697284005059 HTH domain; Region: HTH_11; cl17392 697284005060 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 697284005061 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 697284005062 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 697284005063 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 697284005064 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 697284005065 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 697284005066 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 697284005067 H+ Antiporter protein; Region: 2A0121; TIGR00900 697284005068 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284005069 MULE transposase domain; Region: MULE; pfam10551 697284005070 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 697284005071 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 697284005072 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 697284005073 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 697284005074 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 697284005075 putative L-serine binding site [chemical binding]; other site 697284005076 Condensation domain; Region: Condensation; pfam00668 697284005077 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284005078 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284005079 acyl-activating enzyme (AAE) consensus motif; other site 697284005080 AMP binding site [chemical binding]; other site 697284005081 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284005082 Condensation domain; Region: Condensation; pfam00668 697284005083 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284005084 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 697284005085 Condensation domain; Region: Condensation; pfam00668 697284005086 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284005087 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284005088 acyl-activating enzyme (AAE) consensus motif; other site 697284005089 AMP binding site [chemical binding]; other site 697284005090 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284005091 Thioesterase domain; Region: Thioesterase; pfam00975 697284005092 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 697284005093 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 697284005094 acyl-activating enzyme (AAE) consensus motif; other site 697284005095 AMP binding site [chemical binding]; other site 697284005096 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 697284005097 Condensation domain; Region: Condensation; pfam00668 697284005098 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 697284005099 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 697284005100 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 697284005101 active site 697284005102 CoA binding site [chemical binding]; other site 697284005103 substrate binding site [chemical binding]; other site 697284005104 serine O-acetyltransferase; Region: cysE; TIGR01172 697284005105 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 697284005106 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 697284005107 active site 697284005108 HIGH motif; other site 697284005109 nucleotide binding site [chemical binding]; other site 697284005110 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 697284005111 Beta-lactamase; Region: Beta-lactamase; pfam00144 697284005112 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 697284005113 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284005114 MULE transposase domain; Region: MULE; pfam10551 697284005115 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 697284005116 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 697284005117 active site 697284005118 metal binding site [ion binding]; metal-binding site 697284005119 HTH-like domain; Region: HTH_21; pfam13276 697284005120 Integrase core domain; Region: rve; pfam00665 697284005121 Integrase core domain; Region: rve_3; cl15866 697284005122 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284005123 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284005124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284005125 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284005126 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 697284005127 OPT oligopeptide transporter protein; Region: OPT; cl14607 697284005128 putative oligopeptide transporter, OPT family; Region: TIGR00733 697284005129 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 697284005130 Na2 binding site [ion binding]; other site 697284005131 putative substrate binding site 1 [chemical binding]; other site 697284005132 Na binding site 1 [ion binding]; other site 697284005133 putative substrate binding site 2 [chemical binding]; other site 697284005134 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 697284005135 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 697284005136 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 697284005137 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697284005138 Coenzyme A binding pocket [chemical binding]; other site 697284005139 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 697284005140 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 697284005141 substrate-cofactor binding pocket; other site 697284005142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284005143 catalytic residue [active] 697284005144 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 697284005145 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 697284005146 NAD(P) binding site [chemical binding]; other site 697284005147 Ferredoxin [Energy production and conversion]; Region: COG1146 697284005148 4Fe-4S binding domain; Region: Fer4; cl02805 697284005149 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 697284005150 Chorismate mutase type II; Region: CM_2; cl00693 697284005151 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 697284005152 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 697284005153 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 697284005154 Transcriptional regulator [Transcription]; Region: LytR; COG1316 697284005155 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 697284005156 Bacterial sugar transferase; Region: Bac_transf; pfam02397 697284005157 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 697284005158 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 697284005159 putative ADP-binding pocket [chemical binding]; other site 697284005160 O-Antigen ligase; Region: Wzy_C; cl04850 697284005161 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 697284005162 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 697284005163 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 697284005164 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 697284005165 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 697284005166 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 697284005167 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 697284005168 inhibitor-cofactor binding pocket; inhibition site 697284005169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284005170 catalytic residue [active] 697284005171 putative trimer interface [polypeptide binding]; other site 697284005172 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 697284005173 putative CoA binding site [chemical binding]; other site 697284005174 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 697284005175 putative trimer interface [polypeptide binding]; other site 697284005176 putative active site [active] 697284005177 putative substrate binding site [chemical binding]; other site 697284005178 putative CoA binding site [chemical binding]; other site 697284005179 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 697284005180 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 697284005181 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 697284005182 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 697284005183 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 697284005184 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 697284005185 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 697284005186 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 697284005187 Chain length determinant protein; Region: Wzz; cl15801 697284005188 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284005189 MULE transposase domain; Region: MULE; pfam10551 697284005190 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 697284005191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697284005192 NAD(P) binding site [chemical binding]; other site 697284005193 active site 697284005194 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 697284005195 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 697284005196 Walker A/P-loop; other site 697284005197 ATP binding site [chemical binding]; other site 697284005198 Q-loop/lid; other site 697284005199 ABC transporter signature motif; other site 697284005200 Walker B; other site 697284005201 D-loop; other site 697284005202 H-loop/switch region; other site 697284005203 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 697284005204 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 697284005205 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 697284005206 Walker A/P-loop; other site 697284005207 ATP binding site [chemical binding]; other site 697284005208 Q-loop/lid; other site 697284005209 ABC transporter signature motif; other site 697284005210 Walker B; other site 697284005211 D-loop; other site 697284005212 H-loop/switch region; other site 697284005213 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 697284005214 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 697284005215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284005216 dimer interface [polypeptide binding]; other site 697284005217 conserved gate region; other site 697284005218 putative PBP binding loops; other site 697284005219 ABC-ATPase subunit interface; other site 697284005220 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 697284005221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284005222 dimer interface [polypeptide binding]; other site 697284005223 conserved gate region; other site 697284005224 putative PBP binding loops; other site 697284005225 ABC-ATPase subunit interface; other site 697284005226 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 697284005227 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 697284005228 peptide binding site [polypeptide binding]; other site 697284005229 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 697284005230 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 697284005231 dimer interface [polypeptide binding]; other site 697284005232 putative radical transfer pathway; other site 697284005233 diiron center [ion binding]; other site 697284005234 tyrosyl radical; other site 697284005235 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 697284005236 Class I ribonucleotide reductase; Region: RNR_I; cd01679 697284005237 active site 697284005238 dimer interface [polypeptide binding]; other site 697284005239 catalytic residues [active] 697284005240 effector binding site; other site 697284005241 R2 peptide binding site; other site 697284005242 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697284005243 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 697284005244 Homeodomain-like domain; Region: HTH_23; pfam13384 697284005245 Winged helix-turn helix; Region: HTH_29; pfam13551 697284005246 Winged helix-turn helix; Region: HTH_33; pfam13592 697284005247 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 697284005248 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 697284005249 dimer interface [polypeptide binding]; other site 697284005250 active site 697284005251 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 697284005252 putative active site [active] 697284005253 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697284005254 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 697284005255 DNA-binding site [nucleotide binding]; DNA binding site 697284005256 UTRA domain; Region: UTRA; pfam07702 697284005257 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284005258 MULE transposase domain; Region: MULE; pfam10551 697284005259 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 697284005260 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 697284005261 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 697284005262 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 697284005263 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 697284005264 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 697284005265 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 697284005266 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 697284005267 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 697284005268 active sites [active] 697284005269 tetramer interface [polypeptide binding]; other site 697284005270 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284005271 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284005272 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284005273 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284005274 HTH-like domain; Region: HTH_21; pfam13276 697284005275 Integrase core domain; Region: rve; pfam00665 697284005276 Integrase core domain; Region: rve_3; cl15866 697284005277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284005278 dimer interface [polypeptide binding]; other site 697284005279 conserved gate region; other site 697284005280 putative PBP binding loops; other site 697284005281 ABC-ATPase subunit interface; other site 697284005282 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 697284005283 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 697284005284 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 697284005285 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 697284005286 Walker A/P-loop; other site 697284005287 ATP binding site [chemical binding]; other site 697284005288 Q-loop/lid; other site 697284005289 ABC transporter signature motif; other site 697284005290 Walker B; other site 697284005291 D-loop; other site 697284005292 H-loop/switch region; other site 697284005293 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 697284005294 Predicted transcriptional regulators [Transcription]; Region: COG1510 697284005295 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 697284005296 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 697284005297 NAD(P) binding site [chemical binding]; other site 697284005298 catalytic residues [active] 697284005299 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 697284005300 stage II sporulation protein P; Region: spore_II_P; TIGR02867 697284005301 Uncharacterized conserved protein [Function unknown]; Region: COG0062 697284005302 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 697284005303 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar1; cd08583 697284005304 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 697284005305 putative active site [active] 697284005306 catalytic site [active] 697284005307 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284005308 MULE transposase domain; Region: MULE; pfam10551 697284005309 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 697284005310 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 697284005311 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 697284005312 active site 697284005313 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 697284005314 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 697284005315 WYL domain; Region: WYL; cl14852 697284005316 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 697284005317 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284005318 MULE transposase domain; Region: MULE; pfam10551 697284005319 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 697284005320 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 697284005321 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 697284005322 Ligand Binding Site [chemical binding]; other site 697284005323 Transcriptional regulator [Transcription]; Region: LytR; COG1316 697284005324 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284005325 MULE transposase domain; Region: MULE; pfam10551 697284005326 Protein of unknown function (DUF964); Region: DUF964; cl01483 697284005327 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 697284005328 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 697284005329 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697284005330 FeS/SAM binding site; other site 697284005331 TRAM domain; Region: TRAM; pfam01938 697284005332 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 697284005333 Propanediol utilisation protein PduL; Region: PduL; pfam06130 697284005334 Propanediol utilisation protein PduL; Region: PduL; pfam06130 697284005335 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 697284005336 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 697284005337 TPP-binding site [chemical binding]; other site 697284005338 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 697284005339 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 697284005340 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 697284005341 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 697284005342 dimer interface [polypeptide binding]; other site 697284005343 PYR/PP interface [polypeptide binding]; other site 697284005344 TPP binding site [chemical binding]; other site 697284005345 substrate binding site [chemical binding]; other site 697284005346 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 697284005347 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 697284005348 active site 697284005349 dimer interface [polypeptide binding]; other site 697284005350 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 697284005351 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 697284005352 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 697284005353 putative active site [active] 697284005354 metal binding site [ion binding]; metal-binding site 697284005355 homodimer binding site [polypeptide binding]; other site 697284005356 phosphodiesterase; Provisional; Region: PRK12704 697284005357 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697284005358 Zn2+ binding site [ion binding]; other site 697284005359 Mg2+ binding site [ion binding]; other site 697284005360 RecX family; Region: RecX; cl00936 697284005361 recombinase A; Provisional; Region: recA; PRK09354 697284005362 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 697284005363 hexamer interface [polypeptide binding]; other site 697284005364 Walker A motif; other site 697284005365 ATP binding site [chemical binding]; other site 697284005366 Walker B motif; other site 697284005367 competence damage-inducible protein A; Provisional; Region: PRK00549 697284005368 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 697284005369 putative MPT binding site; other site 697284005370 Competence-damaged protein; Region: CinA; pfam02464 697284005371 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 697284005372 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 697284005373 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 697284005374 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697284005375 FeS/SAM binding site; other site 697284005376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 697284005377 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 697284005378 Helix-turn-helix domain; Region: HTH_25; pfam13413 697284005379 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 697284005380 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 697284005381 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 697284005382 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 697284005383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697284005384 NAD(P) binding site [chemical binding]; other site 697284005385 active site 697284005386 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 697284005387 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 697284005388 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 697284005389 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 697284005390 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 697284005391 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 697284005392 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 697284005393 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 697284005394 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 697284005395 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 697284005396 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 697284005397 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 697284005398 YlzJ-like protein; Region: YlzJ; pfam14035 697284005399 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 697284005400 Clp protease; Region: CLP_protease; pfam00574 697284005401 active site 697284005402 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 697284005403 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 697284005404 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 697284005405 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 697284005406 dihydrodipicolinate synthase; Region: dapA; TIGR00674 697284005407 dimer interface [polypeptide binding]; other site 697284005408 active site 697284005409 catalytic residue [active] 697284005410 aspartate kinase I; Reviewed; Region: PRK08210 697284005411 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 697284005412 nucleotide binding site [chemical binding]; other site 697284005413 substrate binding site [chemical binding]; other site 697284005414 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 697284005415 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 697284005416 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 697284005417 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 697284005418 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 697284005419 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 697284005420 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 697284005421 NAD binding site [chemical binding]; other site 697284005422 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 697284005423 trimer interface [polypeptide binding]; other site 697284005424 active site 697284005425 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 697284005426 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 697284005427 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 697284005428 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 697284005429 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 697284005430 NodB motif; other site 697284005431 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 697284005432 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 697284005433 RNase E interface [polypeptide binding]; other site 697284005434 trimer interface [polypeptide binding]; other site 697284005435 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 697284005436 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 697284005437 RNase E interface [polypeptide binding]; other site 697284005438 trimer interface [polypeptide binding]; other site 697284005439 active site 697284005440 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 697284005441 putative nucleic acid binding region [nucleotide binding]; other site 697284005442 G-X-X-G motif; other site 697284005443 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 697284005444 RNA binding site [nucleotide binding]; other site 697284005445 domain interface; other site 697284005446 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 697284005447 16S/18S rRNA binding site [nucleotide binding]; other site 697284005448 S13e-L30e interaction site [polypeptide binding]; other site 697284005449 25S rRNA binding site [nucleotide binding]; other site 697284005450 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 697284005451 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 697284005452 active site 697284005453 Riboflavin kinase; Region: Flavokinase; smart00904 697284005454 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 697284005455 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 697284005456 RNA binding site [nucleotide binding]; other site 697284005457 active site 697284005458 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 697284005459 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 697284005460 DHH family; Region: DHH; pfam01368 697284005461 DHHA1 domain; Region: DHHA1; pfam02272 697284005462 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 697284005463 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 697284005464 translation initiation factor IF-2; Region: IF-2; TIGR00487 697284005465 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 697284005466 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 697284005467 G1 box; other site 697284005468 putative GEF interaction site [polypeptide binding]; other site 697284005469 GTP/Mg2+ binding site [chemical binding]; other site 697284005470 Switch I region; other site 697284005471 G2 box; other site 697284005472 G3 box; other site 697284005473 Switch II region; other site 697284005474 G4 box; other site 697284005475 G5 box; other site 697284005476 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 697284005477 Translation-initiation factor 2; Region: IF-2; pfam11987 697284005478 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 697284005479 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 697284005480 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 697284005481 putative RNA binding cleft [nucleotide binding]; other site 697284005482 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 697284005483 NusA N-terminal domain; Region: NusA_N; pfam08529 697284005484 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 697284005485 RNA binding site [nucleotide binding]; other site 697284005486 homodimer interface [polypeptide binding]; other site 697284005487 NusA-like KH domain; Region: KH_5; pfam13184 697284005488 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 697284005489 G-X-X-G motif; other site 697284005490 ribosome maturation protein RimP; Reviewed; Region: PRK00092 697284005491 Sm and related proteins; Region: Sm_like; cl00259 697284005492 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 697284005493 putative oligomer interface [polypeptide binding]; other site 697284005494 putative RNA binding site [nucleotide binding]; other site 697284005495 DNA polymerase III PolC; Validated; Region: polC; PRK00448 697284005496 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 697284005497 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 697284005498 generic binding surface II; other site 697284005499 generic binding surface I; other site 697284005500 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 697284005501 active site 697284005502 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 697284005503 active site 697284005504 catalytic site [active] 697284005505 substrate binding site [chemical binding]; other site 697284005506 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 697284005507 prolyl-tRNA synthetase; Provisional; Region: PRK08661 697284005508 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 697284005509 dimer interface [polypeptide binding]; other site 697284005510 motif 1; other site 697284005511 active site 697284005512 motif 2; other site 697284005513 motif 3; other site 697284005514 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 697284005515 anticodon binding site; other site 697284005516 zinc-binding site [ion binding]; other site 697284005517 RIP metalloprotease RseP; Region: TIGR00054 697284005518 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 697284005519 active site 697284005520 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 697284005521 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 697284005522 putative substrate binding region [chemical binding]; other site 697284005523 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 697284005524 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 697284005525 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 697284005526 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 697284005527 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 697284005528 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 697284005529 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 697284005530 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 697284005531 catalytic residue [active] 697284005532 putative FPP diphosphate binding site; other site 697284005533 putative FPP binding hydrophobic cleft; other site 697284005534 dimer interface [polypeptide binding]; other site 697284005535 putative IPP diphosphate binding site; other site 697284005536 ribosome recycling factor; Reviewed; Region: frr; PRK00083 697284005537 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 697284005538 hinge region; other site 697284005539 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 697284005540 putative nucleotide binding site [chemical binding]; other site 697284005541 uridine monophosphate binding site [chemical binding]; other site 697284005542 homohexameric interface [polypeptide binding]; other site 697284005543 elongation factor Ts; Reviewed; Region: tsf; PRK12332 697284005544 UBA/TS-N domain; Region: UBA; pfam00627 697284005545 Elongation factor TS; Region: EF_TS; pfam00889 697284005546 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 697284005547 rRNA interaction site [nucleotide binding]; other site 697284005548 S8 interaction site; other site 697284005549 putative laminin-1 binding site; other site 697284005550 Protein of unknown function (DUF342); Region: DUF342; pfam03961 697284005551 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 697284005552 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 697284005553 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697284005554 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 697284005555 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697284005556 DNA binding residues [nucleotide binding] 697284005557 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488 697284005558 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 697284005559 CheC-like family; Region: CheC; pfam04509 697284005560 CheC-like family; Region: CheC; pfam04509 697284005561 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 697284005562 putative CheA interaction surface; other site 697284005563 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 697284005564 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 697284005565 putative binding surface; other site 697284005566 active site 697284005567 P2 response regulator binding domain; Region: P2; pfam07194 697284005568 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 697284005569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284005570 ATP binding site [chemical binding]; other site 697284005571 Mg2+ binding site [ion binding]; other site 697284005572 G-X-G motif; other site 697284005573 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 697284005574 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 697284005575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284005576 active site 697284005577 phosphorylation site [posttranslational modification] 697284005578 intermolecular recognition site; other site 697284005579 dimerization interface [polypeptide binding]; other site 697284005580 CheB methylesterase; Region: CheB_methylest; pfam01339 697284005581 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 697284005582 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 697284005583 P-loop; other site 697284005584 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 697284005585 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 697284005586 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 697284005587 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 697284005588 FHIPEP family; Region: FHIPEP; pfam00771 697284005589 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 697284005590 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 697284005591 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 697284005592 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 697284005593 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 697284005594 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 697284005595 Response regulator receiver domain; Region: Response_reg; pfam00072 697284005596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284005597 active site 697284005598 phosphorylation site [posttranslational modification] 697284005599 intermolecular recognition site; other site 697284005600 dimerization interface [polypeptide binding]; other site 697284005601 flagellar motor switch protein; Validated; Region: PRK08119 697284005602 CheC-like family; Region: CheC; pfam04509 697284005603 CheC-like family; Region: CheC; pfam04509 697284005604 flagellar motor switch protein FliN; Region: fliN; TIGR02480 697284005605 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 697284005606 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 697284005607 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 697284005608 Flagellar protein (FlbD); Region: FlbD; pfam06289 697284005609 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 697284005610 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 697284005611 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 697284005612 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 697284005613 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 697284005614 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 697284005615 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 697284005616 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 697284005617 Uncharacterized conserved protein [Function unknown]; Region: COG3334 697284005618 MgtE intracellular N domain; Region: MgtE_N; cl15244 697284005619 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 697284005620 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 697284005621 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 697284005622 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 697284005623 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 697284005624 Walker A motif/ATP binding site; other site 697284005625 Walker B motif; other site 697284005626 flagellar assembly protein H; Validated; Region: fliH; PRK06669 697284005627 Flagellar assembly protein FliH; Region: FliH; pfam02108 697284005628 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 697284005629 FliG C-terminal domain; Region: FliG_C; pfam01706 697284005630 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 697284005631 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 697284005632 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 697284005633 flagellar hook-basal body protein FliE; Provisional; Region: fliE; PRK12728 697284005634 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 697284005635 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 697284005636 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 697284005637 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 697284005638 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 697284005639 transcriptional repressor CodY; Validated; Region: PRK04158 697284005640 CodY GAF-like domain; Region: CodY; pfam06018 697284005641 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 697284005642 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 697284005643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697284005644 Walker A motif; other site 697284005645 ATP binding site [chemical binding]; other site 697284005646 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 697284005647 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 697284005648 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 697284005649 active site 697284005650 HslU subunit interaction site [polypeptide binding]; other site 697284005651 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 697284005652 Glucose inhibited division protein A; Region: GIDA; pfam01134 697284005653 DNA topoisomerase I; Validated; Region: PRK05582 697284005654 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 697284005655 active site 697284005656 interdomain interaction site; other site 697284005657 putative metal-binding site [ion binding]; other site 697284005658 nucleotide binding site [chemical binding]; other site 697284005659 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 697284005660 domain I; other site 697284005661 DNA binding groove [nucleotide binding] 697284005662 phosphate binding site [ion binding]; other site 697284005663 domain II; other site 697284005664 domain III; other site 697284005665 nucleotide binding site [chemical binding]; other site 697284005666 catalytic site [active] 697284005667 domain IV; other site 697284005668 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 697284005669 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 697284005670 DNA protecting protein DprA; Region: dprA; TIGR00732 697284005671 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284005672 MULE transposase domain; Region: MULE; pfam10551 697284005673 DNA protecting protein DprA; Region: dprA; TIGR00732 697284005674 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 697284005675 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284005676 MULE transposase domain; Region: MULE; pfam10551 697284005677 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 697284005678 CoA binding domain; Region: CoA_binding; smart00881 697284005679 CoA-ligase; Region: Ligase_CoA; pfam00549 697284005680 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 697284005681 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 697284005682 CoA-ligase; Region: Ligase_CoA; pfam00549 697284005683 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 697284005684 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 697284005685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697284005686 Walker A motif; other site 697284005687 ATP binding site [chemical binding]; other site 697284005688 Walker B motif; other site 697284005689 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 697284005690 hypothetical protein; Reviewed; Region: PRK12497 697284005691 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 697284005692 60S ribosomal protein L19-like protein; Provisional; Region: PTZ00436 697284005693 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 697284005694 RNA/DNA hybrid binding site [nucleotide binding]; other site 697284005695 active site 697284005696 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 697284005697 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 697284005698 GTP/Mg2+ binding site [chemical binding]; other site 697284005699 G4 box; other site 697284005700 G5 box; other site 697284005701 G1 box; other site 697284005702 Switch I region; other site 697284005703 G2 box; other site 697284005704 G3 box; other site 697284005705 Switch II region; other site 697284005706 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 697284005707 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 697284005708 Catalytic site [active] 697284005709 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 697284005710 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 697284005711 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 697284005712 RimM N-terminal domain; Region: RimM; pfam01782 697284005713 PRC-barrel domain; Region: PRC; pfam05239 697284005714 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 697284005715 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 697284005716 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 697284005717 signal recognition particle protein; Provisional; Region: PRK10867 697284005718 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 697284005719 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 697284005720 P loop; other site 697284005721 GTP binding site [chemical binding]; other site 697284005722 Signal peptide binding domain; Region: SRP_SPB; pfam02978 697284005723 putative DNA-binding protein; Validated; Region: PRK00118 697284005724 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 697284005725 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 697284005726 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 697284005727 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 697284005728 P loop; other site 697284005729 GTP binding site [chemical binding]; other site 697284005730 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 697284005731 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 697284005732 Walker A/P-loop; other site 697284005733 ATP binding site [chemical binding]; other site 697284005734 Q-loop/lid; other site 697284005735 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 697284005736 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 697284005737 Q-loop/lid; other site 697284005738 ABC transporter signature motif; other site 697284005739 Walker B; other site 697284005740 D-loop; other site 697284005741 H-loop/switch region; other site 697284005742 ribonuclease III; Reviewed; Region: rnc; PRK00102 697284005743 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 697284005744 dimerization interface [polypeptide binding]; other site 697284005745 active site 697284005746 metal binding site [ion binding]; metal-binding site 697284005747 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 697284005748 dsRNA binding site [nucleotide binding]; other site 697284005749 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 697284005750 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 697284005751 dimer interface [polypeptide binding]; other site 697284005752 active site 697284005753 acyl carrier protein; Provisional; Region: acpP; PRK00982 697284005754 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 697284005755 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 697284005756 NAD(P) binding site [chemical binding]; other site 697284005757 homotetramer interface [polypeptide binding]; other site 697284005758 homodimer interface [polypeptide binding]; other site 697284005759 active site 697284005760 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 697284005761 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 697284005762 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 697284005763 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 697284005764 dimer interface [polypeptide binding]; other site 697284005765 active site 697284005766 CoA binding pocket [chemical binding]; other site 697284005767 putative phosphate acyltransferase; Provisional; Region: PRK05331 697284005768 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 697284005769 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 697284005770 active site 2 [active] 697284005771 active site 1 [active] 697284005772 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 697284005773 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 697284005774 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 697284005775 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 697284005776 protein binding site [polypeptide binding]; other site 697284005777 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 697284005778 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 697284005779 Nucleoside recognition; Region: Gate; pfam07670 697284005780 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 697284005781 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 697284005782 active site 697284005783 (T/H)XGH motif; other site 697284005784 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 697284005785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284005786 S-adenosylmethionine binding site [chemical binding]; other site 697284005787 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697284005788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284005789 non-specific DNA binding site [nucleotide binding]; other site 697284005790 salt bridge; other site 697284005791 sequence-specific DNA binding site [nucleotide binding]; other site 697284005792 Amidinotransferase; Region: Amidinotransf; cl12043 697284005793 Integrase core domain; Region: rve_3; cl15866 697284005794 Chitin binding domain; Region: Chitin_bind_3; pfam03067 697284005795 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 697284005796 Interdomain contacts; other site 697284005797 Cytokine receptor motif; other site 697284005798 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 697284005799 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 697284005800 Interdomain contacts; other site 697284005801 Cytokine receptor motif; other site 697284005802 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 697284005803 aromatic chitin/cellulose binding site residues [chemical binding]; other site 697284005804 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 697284005805 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 697284005806 amidase catalytic site [active] 697284005807 Zn binding residues [ion binding]; other site 697284005808 substrate binding site [chemical binding]; other site 697284005809 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 697284005810 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284005811 Transposase; Region: HTH_Tnp_1; pfam01527 697284005812 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 697284005813 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 697284005814 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284005815 non-specific DNA binding site [nucleotide binding]; other site 697284005816 salt bridge; other site 697284005817 sequence-specific DNA binding site [nucleotide binding]; other site 697284005818 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284005819 non-specific DNA binding site [nucleotide binding]; other site 697284005820 salt bridge; other site 697284005821 sequence-specific DNA binding site [nucleotide binding]; other site 697284005822 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 697284005823 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 697284005824 DNA binding site [nucleotide binding] 697284005825 active site 697284005826 Int/Topo IB signature motif; other site 697284005827 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 697284005828 dimer interface [polypeptide binding]; other site 697284005829 FMN binding site [chemical binding]; other site 697284005830 NADPH bind site [chemical binding]; other site 697284005831 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 697284005832 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 697284005833 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 697284005834 NAD(P) binding site [chemical binding]; other site 697284005835 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 697284005836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697284005837 dimer interface [polypeptide binding]; other site 697284005838 phosphorylation site [posttranslational modification] 697284005839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284005840 ATP binding site [chemical binding]; other site 697284005841 Mg2+ binding site [ion binding]; other site 697284005842 G-X-G motif; other site 697284005843 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 697284005844 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697284005845 YolD-like protein; Region: YolD; pfam08863 697284005846 DNA polymerase IV; Reviewed; Region: PRK03103 697284005847 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 697284005848 active site 697284005849 DNA binding site [nucleotide binding] 697284005850 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 697284005851 Low molecular weight phosphatase family; Region: LMWPc; cl00105 697284005852 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 697284005853 arsenical-resistance protein; Region: acr3; TIGR00832 697284005854 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697284005855 dimerization interface [polypeptide binding]; other site 697284005856 putative DNA binding site [nucleotide binding]; other site 697284005857 putative Zn2+ binding site [ion binding]; other site 697284005858 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697284005859 dimerization interface [polypeptide binding]; other site 697284005860 putative DNA binding site [nucleotide binding]; other site 697284005861 putative Zn2+ binding site [ion binding]; other site 697284005862 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 697284005863 Heavy-metal-associated domain; Region: HMA; pfam00403 697284005864 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 697284005865 Soluble P-type ATPase [General function prediction only]; Region: COG4087 697284005866 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284005867 MULE transposase domain; Region: MULE; pfam10551 697284005868 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 697284005869 NADH(P)-binding; Region: NAD_binding_10; pfam13460 697284005870 NAD binding site [chemical binding]; other site 697284005871 substrate binding site [chemical binding]; other site 697284005872 putative active site [active] 697284005873 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 697284005874 Domain of unknown function DUF21; Region: DUF21; pfam01595 697284005875 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 697284005876 Transporter associated domain; Region: CorC_HlyC; smart01091 697284005877 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 697284005878 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 697284005879 A new structural DNA glycosylase; Region: AlkD_like; cl11434 697284005880 HEAT repeats; Region: HEAT_2; pfam13646 697284005881 active site 697284005882 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 697284005883 Y-family of DNA polymerases; Region: PolY; cl12025 697284005884 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 697284005885 generic binding surface II; other site 697284005886 ssDNA binding site; other site 697284005887 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697284005888 putative Mg++ binding site [ion binding]; other site 697284005889 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697284005890 nucleotide binding region [chemical binding]; other site 697284005891 ATP-binding site [chemical binding]; other site 697284005892 EDD domain protein, DegV family; Region: DegV; TIGR00762 697284005893 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 697284005894 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 697284005895 DAK2 domain; Region: Dak2; pfam02734 697284005896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 697284005897 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 697284005898 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 697284005899 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 697284005900 substrate binding site [chemical binding]; other site 697284005901 hexamer interface [polypeptide binding]; other site 697284005902 metal binding site [ion binding]; metal-binding site 697284005903 GTPase RsgA; Reviewed; Region: PRK00098 697284005904 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 697284005905 RNA binding site [nucleotide binding]; other site 697284005906 homodimer interface [polypeptide binding]; other site 697284005907 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 697284005908 GTPase/Zn-binding domain interface [polypeptide binding]; other site 697284005909 GTP/Mg2+ binding site [chemical binding]; other site 697284005910 G4 box; other site 697284005911 G5 box; other site 697284005912 G1 box; other site 697284005913 Switch I region; other site 697284005914 G2 box; other site 697284005915 G3 box; other site 697284005916 Switch II region; other site 697284005917 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 697284005918 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 697284005919 active site 697284005920 ATP binding site [chemical binding]; other site 697284005921 substrate binding site [chemical binding]; other site 697284005922 activation loop (A-loop); other site 697284005923 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 697284005924 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 697284005925 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 697284005926 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 697284005927 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 697284005928 Protein phosphatase 2C; Region: PP2C; pfam00481 697284005929 active site 697284005930 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 697284005931 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697284005932 FeS/SAM binding site; other site 697284005933 16S rRNA methyltransferase B; Provisional; Region: PRK14902 697284005934 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 697284005935 putative RNA binding site [nucleotide binding]; other site 697284005936 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 697284005937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284005938 S-adenosylmethionine binding site [chemical binding]; other site 697284005939 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 697284005940 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 697284005941 putative active site [active] 697284005942 substrate binding site [chemical binding]; other site 697284005943 putative cosubstrate binding site; other site 697284005944 catalytic site [active] 697284005945 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 697284005946 substrate binding site [chemical binding]; other site 697284005947 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 697284005948 active site 697284005949 catalytic residues [active] 697284005950 metal binding site [ion binding]; metal-binding site 697284005951 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697284005952 primosomal protein N' Region: priA; TIGR00595 697284005953 ATP binding site [chemical binding]; other site 697284005954 putative Mg++ binding site [ion binding]; other site 697284005955 helicase superfamily c-terminal domain; Region: HELICc; smart00490 697284005956 ATP-binding site [chemical binding]; other site 697284005957 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 697284005958 Flavoprotein; Region: Flavoprotein; pfam02441 697284005959 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 697284005960 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 697284005961 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 697284005962 catalytic site [active] 697284005963 G-X2-G-X-G-K; other site 697284005964 hypothetical protein; Provisional; Region: PRK04323 697284005965 hypothetical protein; Provisional; Region: PRK11820 697284005966 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 697284005967 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 697284005968 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 697284005969 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 697284005970 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 697284005971 FAD binding site [chemical binding]; other site 697284005972 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 697284005973 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 697284005974 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 697284005975 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 697284005976 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 697284005977 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 697284005978 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 697284005979 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697284005980 motif II; other site 697284005981 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 697284005982 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 697284005983 Domain of unknown function (DUF814); Region: DUF814; pfam05670 697284005984 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 697284005985 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 697284005986 active site 697284005987 tetramer interface; other site 697284005988 Transcriptional regulator [Transcription]; Region: LysR; COG0583 697284005989 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 697284005990 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 697284005991 putative dimerization interface [polypeptide binding]; other site 697284005992 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 697284005993 L-asparaginase II; Region: Asparaginase_II; pfam06089 697284005994 Protein of unknown function (DUF964); Region: DUF964; cl01483 697284005995 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 697284005996 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 697284005997 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697284005998 FOG: CBS domain [General function prediction only]; Region: COG0517 697284005999 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 697284006000 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 697284006001 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 697284006002 dimer interface [polypeptide binding]; other site 697284006003 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 697284006004 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 697284006005 YugN-like family; Region: YugN; pfam08868 697284006006 cell division protein FtsW; Region: ftsW; TIGR02614 697284006007 Asp23 family; Region: Asp23; pfam03780 697284006008 calcium/proton exchanger (cax); Region: cax; TIGR00378 697284006009 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 697284006010 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 697284006011 hypothetical protein; Provisional; Region: PRK13666 697284006012 Uncharacterized conserved protein [Function unknown]; Region: COG0398 697284006013 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 697284006014 GAF domain; Region: GAF_3; pfam13492 697284006015 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 697284006016 GAF domain; Region: GAF_3; pfam13492 697284006017 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 697284006018 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 697284006019 metal binding site [ion binding]; metal-binding site 697284006020 active site 697284006021 I-site; other site 697284006022 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 697284006023 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 697284006024 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697284006025 RNA binding surface [nucleotide binding]; other site 697284006026 Transglycosylase; Region: Transgly; pfam00912 697284006027 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 697284006028 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 697284006029 acetyl-CoA synthetase; Provisional; Region: PRK04319 697284006030 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 697284006031 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 697284006032 active site 697284006033 acyl-activating enzyme (AAE) consensus motif; other site 697284006034 putative CoA binding site [chemical binding]; other site 697284006035 AMP binding site [chemical binding]; other site 697284006036 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697284006037 Coenzyme A binding pocket [chemical binding]; other site 697284006038 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 697284006039 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 697284006040 active site 697284006041 Zn binding site [ion binding]; other site 697284006042 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 697284006043 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 697284006044 catabolite control protein A; Region: ccpA; TIGR01481 697284006045 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697284006046 DNA binding site [nucleotide binding] 697284006047 domain linker motif; other site 697284006048 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 697284006049 dimerization interface [polypeptide binding]; other site 697284006050 effector binding site; other site 697284006051 intracellular protease, PfpI family; Region: PfpI; TIGR01382 697284006052 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 697284006053 proposed catalytic triad [active] 697284006054 conserved cys residue [active] 697284006055 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 697284006056 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 697284006057 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 697284006058 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 697284006059 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 697284006060 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 697284006061 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 697284006062 active site turn [active] 697284006063 phosphorylation site [posttranslational modification] 697284006064 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 697284006065 HPr interaction site; other site 697284006066 glycerol kinase (GK) interaction site [polypeptide binding]; other site 697284006067 active site 697284006068 phosphorylation site [posttranslational modification] 697284006069 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284006070 MULE transposase domain; Region: MULE; pfam10551 697284006071 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 697284006072 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 697284006073 putative active site [active] 697284006074 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 697284006075 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 697284006076 hinge; other site 697284006077 active site 697284006078 camphor resistance protein CrcB; Provisional; Region: PRK14205 697284006079 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 697284006080 shikimate kinase; Provisional; Region: PRK13947 697284006081 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 697284006082 ADP binding site [chemical binding]; other site 697284006083 magnesium binding site [ion binding]; other site 697284006084 putative shikimate binding site; other site 697284006085 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 697284006086 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 697284006087 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 697284006088 Walker A/P-loop; other site 697284006089 ATP binding site [chemical binding]; other site 697284006090 Q-loop/lid; other site 697284006091 ABC transporter signature motif; other site 697284006092 Walker B; other site 697284006093 D-loop; other site 697284006094 H-loop/switch region; other site 697284006095 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 697284006096 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284006097 MULE transposase domain; Region: MULE; pfam10551 697284006098 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 697284006099 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 697284006100 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 697284006101 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 697284006102 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 697284006103 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 697284006104 active site 697284006105 Zn binding site [ion binding]; other site 697284006106 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 697284006107 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284006108 MULE transposase domain; Region: MULE; pfam10551 697284006109 hypothetical protein; Provisional; Region: PRK04081 697284006110 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 697284006111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284006112 non-specific DNA binding site [nucleotide binding]; other site 697284006113 salt bridge; other site 697284006114 sequence-specific DNA binding site [nucleotide binding]; other site 697284006115 Domain of unknown function (DUF955); Region: DUF955; cl01076 697284006116 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284006117 MULE transposase domain; Region: MULE; pfam10551 697284006118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697284006119 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 697284006120 Walker A motif; other site 697284006121 ATP binding site [chemical binding]; other site 697284006122 Walker B motif; other site 697284006123 arginine finger; other site 697284006124 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 697284006125 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 697284006126 amidase catalytic site [active] 697284006127 Zn binding residues [ion binding]; other site 697284006128 substrate binding site [chemical binding]; other site 697284006129 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 697284006130 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 697284006131 Kelch motif; Region: Kelch_1; pfam01344 697284006132 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 697284006133 Kelch domain; Region: Kelch; smart00612 697284006134 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 697284006135 Kelch domain; Region: Kelch; smart00612 697284006136 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 697284006137 Kelch domain; Region: Kelch; smart00612 697284006138 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 697284006139 Kelch motif; Region: Kelch_1; pfam01344 697284006140 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 697284006141 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 697284006142 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 697284006143 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 697284006144 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 697284006145 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 697284006146 Phage XkdN-like protein; Region: XkdN; pfam08890 697284006147 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 697284006148 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 697284006149 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 697284006150 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 697284006151 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284006152 MULE transposase domain; Region: MULE; pfam10551 697284006153 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 697284006154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284006155 active site 697284006156 phosphorylation site [posttranslational modification] 697284006157 intermolecular recognition site; other site 697284006158 dimerization interface [polypeptide binding]; other site 697284006159 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 697284006160 DNA binding residues [nucleotide binding] 697284006161 dimerization interface [polypeptide binding]; other site 697284006162 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 697284006163 substrate binding site [chemical binding]; other site 697284006164 catalytic residues [active] 697284006165 hypothetical protein; Provisional; Region: PRK02947 697284006166 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 697284006167 putative active site [active] 697284006168 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 697284006169 hypothetical protein; Provisional; Region: PRK02947 697284006170 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 697284006171 putative active site [active] 697284006172 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 697284006173 active site 697284006174 phosphorylation site [posttranslational modification] 697284006175 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 697284006176 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 697284006177 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 697284006178 active pocket/dimerization site; other site 697284006179 active site 697284006180 phosphorylation site [posttranslational modification] 697284006181 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 697284006182 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697284006183 DNA-binding site [nucleotide binding]; DNA binding site 697284006184 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 697284006185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 697284006186 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 697284006187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284006188 Major Facilitator Superfamily; Region: MFS_1; pfam07690 697284006189 putative substrate translocation pore; other site 697284006190 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 697284006191 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 697284006192 homodimer interface [polypeptide binding]; other site 697284006193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284006194 catalytic residue [active] 697284006195 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 697284006196 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 697284006197 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 697284006198 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 697284006199 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 697284006200 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 697284006201 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 697284006202 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 697284006203 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 697284006204 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 697284006205 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 697284006206 active site 697284006207 I-site; other site 697284006208 metal binding site [ion binding]; metal-binding site 697284006209 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697284006210 dimer interface [polypeptide binding]; other site 697284006211 phosphorylation site [posttranslational modification] 697284006212 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 697284006213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284006214 ATP binding site [chemical binding]; other site 697284006215 Mg2+ binding site [ion binding]; other site 697284006216 G-X-G motif; other site 697284006217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 697284006218 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284006219 MULE transposase domain; Region: MULE; pfam10551 697284006220 Divergent PAP2 family; Region: DUF212; pfam02681 697284006221 FOG: CBS domain [General function prediction only]; Region: COG0517 697284006222 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 697284006223 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 697284006224 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 697284006225 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 697284006226 Walker A/P-loop; other site 697284006227 ATP binding site [chemical binding]; other site 697284006228 Q-loop/lid; other site 697284006229 ABC transporter signature motif; other site 697284006230 Walker B; other site 697284006231 D-loop; other site 697284006232 H-loop/switch region; other site 697284006233 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 697284006234 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 697284006235 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697284006236 Walker A/P-loop; other site 697284006237 ATP binding site [chemical binding]; other site 697284006238 Q-loop/lid; other site 697284006239 ABC transporter signature motif; other site 697284006240 Walker B; other site 697284006241 D-loop; other site 697284006242 H-loop/switch region; other site 697284006243 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 697284006244 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284006245 MULE transposase domain; Region: MULE; pfam10551 697284006246 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 697284006247 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284006248 MULE transposase domain; Region: MULE; pfam10551 697284006249 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 697284006250 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284006251 MULE transposase domain; Region: MULE; pfam10551 697284006252 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284006253 non-specific DNA binding site [nucleotide binding]; other site 697284006254 salt bridge; other site 697284006255 sequence-specific DNA binding site [nucleotide binding]; other site 697284006256 Homeodomain-like domain; Region: HTH_23; pfam13384 697284006257 Winged helix-turn helix; Region: HTH_29; pfam13551 697284006258 Winged helix-turn helix; Region: HTH_33; pfam13592 697284006259 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697284006260 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 697284006261 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697284006262 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284006263 non-specific DNA binding site [nucleotide binding]; other site 697284006264 salt bridge; other site 697284006265 sequence-specific DNA binding site [nucleotide binding]; other site 697284006266 Domain of unknown function (DUF955); Region: DUF955; cl01076 697284006267 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284006268 MULE transposase domain; Region: MULE; pfam10551 697284006269 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 697284006270 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 697284006271 Int/Topo IB signature motif; other site 697284006272 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 697284006273 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284006274 MULE transposase domain; Region: MULE; pfam10551 697284006275 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cl00559 697284006276 hypothetical protein; Provisional; Region: PRK13679 697284006277 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 697284006278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 697284006279 HTH-like domain; Region: HTH_21; pfam13276 697284006280 Integrase core domain; Region: rve; pfam00665 697284006281 Integrase core domain; Region: rve_2; pfam13333 697284006282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284006283 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284006284 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284006285 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 697284006286 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 697284006287 hypothetical protein; Provisional; Region: PRK08201 697284006288 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 697284006289 metal binding site [ion binding]; metal-binding site 697284006290 putative dimer interface [polypeptide binding]; other site 697284006291 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697284006292 active site 697284006293 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 697284006294 active site 697284006295 dimer interface [polypeptide binding]; other site 697284006296 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 697284006297 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 697284006298 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 697284006299 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 697284006300 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 697284006301 ATP-grasp domain; Region: ATP-grasp_4; cl17255 697284006302 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 697284006303 IMP binding site; other site 697284006304 dimer interface [polypeptide binding]; other site 697284006305 interdomain contacts; other site 697284006306 partial ornithine binding site; other site 697284006307 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 697284006308 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 697284006309 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 697284006310 catalytic site [active] 697284006311 subunit interface [polypeptide binding]; other site 697284006312 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 697284006313 dihydroorotase; Validated; Region: pyrC; PRK09357 697284006314 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 697284006315 active site 697284006316 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 697284006317 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 697284006318 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 697284006319 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 697284006320 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697284006321 active site 697284006322 aspartate aminotransferase; Provisional; Region: PRK06290 697284006323 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 697284006324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284006325 homodimer interface [polypeptide binding]; other site 697284006326 catalytic residue [active] 697284006327 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 697284006328 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697284006329 RNA binding surface [nucleotide binding]; other site 697284006330 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 697284006331 active site 697284006332 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 697284006333 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 697284006334 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 697284006335 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 697284006336 HIGH motif; other site 697284006337 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 697284006338 active site 697284006339 KMSKS motif; other site 697284006340 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 697284006341 tRNA binding surface [nucleotide binding]; other site 697284006342 anticodon binding site; other site 697284006343 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 697284006344 DivIVA protein; Region: DivIVA; pfam05103 697284006345 DivIVA domain; Region: DivI1A_domain; TIGR03544 697284006346 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 697284006347 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697284006348 RNA binding surface [nucleotide binding]; other site 697284006349 YGGT family; Region: YGGT; pfam02325 697284006350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 697284006351 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 697284006352 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 697284006353 catalytic residue [active] 697284006354 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 697284006355 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 697284006356 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 697284006357 sporulation sigma factor SigG; Reviewed; Region: PRK08215 697284006358 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697284006359 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 697284006360 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697284006361 DNA binding residues [nucleotide binding] 697284006362 sporulation sigma factor SigE; Reviewed; Region: PRK08301 697284006363 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697284006364 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697284006365 DNA binding residues [nucleotide binding] 697284006366 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 697284006367 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 697284006368 cell division protein FtsZ; Validated; Region: PRK09330 697284006369 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 697284006370 nucleotide binding site [chemical binding]; other site 697284006371 SulA interaction site; other site 697284006372 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 697284006373 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 697284006374 nucleotide binding site [chemical binding]; other site 697284006375 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 697284006376 Cell division protein FtsA; Region: FtsA; pfam14450 697284006377 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 697284006378 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 697284006379 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 697284006380 hinge; other site 697284006381 active site 697284006382 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 697284006383 FAD binding domain; Region: FAD_binding_4; pfam01565 697284006384 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 697284006385 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 697284006386 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 697284006387 active site 697284006388 homodimer interface [polypeptide binding]; other site 697284006389 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 697284006390 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 697284006391 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 697284006392 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 697284006393 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 697284006394 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 697284006395 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 697284006396 Mg++ binding site [ion binding]; other site 697284006397 putative catalytic motif [active] 697284006398 putative substrate binding site [chemical binding]; other site 697284006399 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 697284006400 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 697284006401 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 697284006402 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 697284006403 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 697284006404 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 697284006405 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 697284006406 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 697284006407 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 697284006408 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 697284006409 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 697284006410 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 697284006411 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 697284006412 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 697284006413 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 697284006414 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 697284006415 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 697284006416 Cell division protein FtsL; Region: FtsL; cl11433 697284006417 MraW methylase family; Region: Methyltransf_5; pfam01795 697284006418 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 697284006419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 697284006420 MraZ protein; Region: MraZ; pfam02381 697284006421 MraZ protein; Region: MraZ; pfam02381 697284006422 HTH-like domain; Region: HTH_21; pfam13276 697284006423 Integrase core domain; Region: rve; pfam00665 697284006424 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 697284006425 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 697284006426 homotetramer interface [polypeptide binding]; other site 697284006427 ligand binding site [chemical binding]; other site 697284006428 catalytic site [active] 697284006429 NAD binding site [chemical binding]; other site 697284006430 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 697284006431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 697284006432 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 697284006433 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 697284006434 Walker A/P-loop; other site 697284006435 ATP binding site [chemical binding]; other site 697284006436 Q-loop/lid; other site 697284006437 ABC transporter signature motif; other site 697284006438 Walker B; other site 697284006439 D-loop; other site 697284006440 H-loop/switch region; other site 697284006441 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 697284006442 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 697284006443 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 697284006444 Walker A/P-loop; other site 697284006445 ATP binding site [chemical binding]; other site 697284006446 Q-loop/lid; other site 697284006447 ABC transporter signature motif; other site 697284006448 Walker B; other site 697284006449 D-loop; other site 697284006450 H-loop/switch region; other site 697284006451 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 697284006452 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 697284006453 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 697284006454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284006455 dimer interface [polypeptide binding]; other site 697284006456 conserved gate region; other site 697284006457 putative PBP binding loops; other site 697284006458 ABC-ATPase subunit interface; other site 697284006459 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 697284006460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284006461 dimer interface [polypeptide binding]; other site 697284006462 conserved gate region; other site 697284006463 putative PBP binding loops; other site 697284006464 ABC-ATPase subunit interface; other site 697284006465 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 697284006466 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 697284006467 peptide binding site [polypeptide binding]; other site 697284006468 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 697284006469 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 697284006470 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 697284006471 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 697284006472 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 697284006473 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 697284006474 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 697284006475 Uncharacterized conserved protein [Function unknown]; Region: COG1565 697284006476 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 697284006477 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 697284006478 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 697284006479 putative active site [active] 697284006480 PhoH-like protein; Region: PhoH; pfam02562 697284006481 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 697284006482 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 697284006483 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 697284006484 YlaH-like protein; Region: YlaH; pfam14036 697284006485 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 697284006486 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 697284006487 G1 box; other site 697284006488 putative GEF interaction site [polypeptide binding]; other site 697284006489 GTP/Mg2+ binding site [chemical binding]; other site 697284006490 Switch I region; other site 697284006491 G2 box; other site 697284006492 G3 box; other site 697284006493 Switch II region; other site 697284006494 G4 box; other site 697284006495 G5 box; other site 697284006496 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 697284006497 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 697284006498 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 697284006499 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 697284006500 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 697284006501 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 697284006502 Ligand Binding Site [chemical binding]; other site 697284006503 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 697284006504 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 697284006505 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697284006506 catalytic residue [active] 697284006507 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 697284006508 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 697284006509 N-acetyl-D-glucosamine binding site [chemical binding]; other site 697284006510 catalytic residue [active] 697284006511 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 697284006512 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 697284006513 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 697284006514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284006515 Walker A/P-loop; other site 697284006516 ATP binding site [chemical binding]; other site 697284006517 Q-loop/lid; other site 697284006518 ABC transporter signature motif; other site 697284006519 Walker B; other site 697284006520 D-loop; other site 697284006521 H-loop/switch region; other site 697284006522 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 697284006523 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 697284006524 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284006525 MULE transposase domain; Region: MULE; pfam10551 697284006526 Uncharacterized conserved protein [Function unknown]; Region: COG0327 697284006527 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 697284006528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 697284006529 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 697284006530 Uncharacterized conserved protein [Function unknown]; Region: COG0327 697284006531 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 697284006532 Family of unknown function (DUF633); Region: DUF633; pfam04816 697284006533 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 697284006534 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 697284006535 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 697284006536 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697284006537 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 697284006538 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697284006539 DNA binding residues [nucleotide binding] 697284006540 DNA primase; Validated; Region: dnaG; PRK05667 697284006541 CHC2 zinc finger; Region: zf-CHC2; pfam01807 697284006542 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 697284006543 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 697284006544 active site 697284006545 metal binding site [ion binding]; metal-binding site 697284006546 interdomain interaction site; other site 697284006547 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 697284006548 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 697284006549 PEP synthetase regulatory protein; Provisional; Region: PRK05339 697284006550 Recombination protein O N terminal; Region: RecO_N; pfam11967 697284006551 DNA repair protein RecO; Region: reco; TIGR00613 697284006552 Recombination protein O C terminal; Region: RecO_C; pfam02565 697284006553 GTPase Era; Reviewed; Region: era; PRK00089 697284006554 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 697284006555 G1 box; other site 697284006556 GTP/Mg2+ binding site [chemical binding]; other site 697284006557 Switch I region; other site 697284006558 G2 box; other site 697284006559 Switch II region; other site 697284006560 G3 box; other site 697284006561 G4 box; other site 697284006562 G5 box; other site 697284006563 KH domain; Region: KH_2; pfam07650 697284006564 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 697284006565 active site 697284006566 catalytic motif [active] 697284006567 Zn binding site [ion binding]; other site 697284006568 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 697284006569 metal-binding heat shock protein; Provisional; Region: PRK00016 697284006570 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 697284006571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284006572 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697284006573 Zn2+ binding site [ion binding]; other site 697284006574 Mg2+ binding site [ion binding]; other site 697284006575 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 697284006576 PhoH-like protein; Region: PhoH; pfam02562 697284006577 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 697284006578 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 697284006579 YabP family; Region: YabP; cl06766 697284006580 Yqey-like protein; Region: YqeY; pfam09424 697284006581 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 697284006582 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 697284006583 nucleotide binding site/active site [active] 697284006584 HIT family signature motif; other site 697284006585 catalytic residue [active] 697284006586 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 697284006587 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697284006588 dimerization interface [polypeptide binding]; other site 697284006589 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697284006590 dimer interface [polypeptide binding]; other site 697284006591 phosphorylation site [posttranslational modification] 697284006592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284006593 ATP binding site [chemical binding]; other site 697284006594 Mg2+ binding site [ion binding]; other site 697284006595 G-X-G motif; other site 697284006596 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697284006597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284006598 active site 697284006599 phosphorylation site [posttranslational modification] 697284006600 intermolecular recognition site; other site 697284006601 dimerization interface [polypeptide binding]; other site 697284006602 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697284006603 DNA binding site [nucleotide binding] 697284006604 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 697284006605 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 697284006606 NodB motif; other site 697284006607 active site 697284006608 catalytic site [active] 697284006609 metal binding site [ion binding]; metal-binding site 697284006610 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 697284006611 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697284006612 FeS/SAM binding site; other site 697284006613 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 697284006614 Pyruvate formate lyase 1; Region: PFL1; cd01678 697284006615 coenzyme A binding site [chemical binding]; other site 697284006616 active site 697284006617 catalytic residues [active] 697284006618 glycine loop; other site 697284006619 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 697284006620 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 697284006621 putative catalytic cysteine [active] 697284006622 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 697284006623 putative active site [active] 697284006624 metal binding site [ion binding]; metal-binding site 697284006625 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284006626 MULE transposase domain; Region: MULE; pfam10551 697284006627 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 697284006628 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 697284006629 GTP binding site; other site 697284006630 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 697284006631 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 697284006632 ligand binding site [chemical binding]; other site 697284006633 flexible hinge region; other site 697284006634 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 697284006635 non-specific DNA interactions [nucleotide binding]; other site 697284006636 DNA binding site [nucleotide binding] 697284006637 sequence specific DNA binding site [nucleotide binding]; other site 697284006638 putative cAMP binding site [chemical binding]; other site 697284006639 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 697284006640 [2Fe-2S] cluster binding site [ion binding]; other site 697284006641 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 697284006642 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 697284006643 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 697284006644 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 697284006645 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 697284006646 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284006647 MULE transposase domain; Region: MULE; pfam10551 697284006648 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 697284006649 AAA domain; Region: AAA_23; pfam13476 697284006650 Walker A/P-loop; other site 697284006651 ATP binding site [chemical binding]; other site 697284006652 Q-loop/lid; other site 697284006653 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 697284006654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284006655 ABC transporter signature motif; other site 697284006656 Walker B; other site 697284006657 D-loop; other site 697284006658 H-loop/switch region; other site 697284006659 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 697284006660 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 697284006661 active site 697284006662 metal binding site [ion binding]; metal-binding site 697284006663 DNA binding site [nucleotide binding] 697284006664 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 697284006665 Part of AAA domain; Region: AAA_19; pfam13245 697284006666 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 697284006667 Family description; Region: UvrD_C_2; pfam13538 697284006668 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 697284006669 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 697284006670 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 697284006671 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697284006672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 697284006673 Winged helix-turn helix; Region: HTH_29; pfam13551 697284006674 Homeodomain-like domain; Region: HTH_32; pfam13565 697284006675 Winged helix-turn helix; Region: HTH_33; pfam13592 697284006676 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284006677 MULE transposase domain; Region: MULE; pfam10551 697284006678 DinB superfamily; Region: DinB_2; pfam12867 697284006679 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 697284006680 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697284006681 Coenzyme A binding pocket [chemical binding]; other site 697284006682 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 697284006683 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 697284006684 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 697284006685 putative RNA binding site [nucleotide binding]; other site 697284006686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284006687 S-adenosylmethionine binding site [chemical binding]; other site 697284006688 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 697284006689 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 697284006690 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 697284006691 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 697284006692 active site 697284006693 Ap6A binding site [chemical binding]; other site 697284006694 nudix motif; other site 697284006695 metal binding site [ion binding]; metal-binding site 697284006696 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 697284006697 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 697284006698 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697284006699 FeS/SAM binding site; other site 697284006700 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 697284006701 RNA methyltransferase, RsmE family; Region: TIGR00046 697284006702 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 697284006703 Peptidase family M50; Region: Peptidase_M50; pfam02163 697284006704 active site 697284006705 putative substrate binding region [chemical binding]; other site 697284006706 YfhD-like protein; Region: YfhD; pfam14151 697284006707 chaperone protein DnaJ; Provisional; Region: PRK14280 697284006708 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 697284006709 HSP70 interaction site [polypeptide binding]; other site 697284006710 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 697284006711 substrate binding site [polypeptide binding]; other site 697284006712 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 697284006713 Zn binding sites [ion binding]; other site 697284006714 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 697284006715 dimer interface [polypeptide binding]; other site 697284006716 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 697284006717 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 697284006718 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 697284006719 nucleotide binding site [chemical binding]; other site 697284006720 NEF interaction site [polypeptide binding]; other site 697284006721 SBD interface [polypeptide binding]; other site 697284006722 heat shock protein GrpE; Provisional; Region: PRK14140 697284006723 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 697284006724 dimer interface [polypeptide binding]; other site 697284006725 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 697284006726 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 697284006727 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 697284006728 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 697284006729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697284006730 Coenzyme A binding pocket [chemical binding]; other site 697284006731 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697284006732 Coenzyme A binding pocket [chemical binding]; other site 697284006733 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 697284006734 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697284006735 FeS/SAM binding site; other site 697284006736 HemN C-terminal domain; Region: HemN_C; pfam06969 697284006737 GTP-binding protein LepA; Provisional; Region: PRK05433 697284006738 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 697284006739 G1 box; other site 697284006740 putative GEF interaction site [polypeptide binding]; other site 697284006741 GTP/Mg2+ binding site [chemical binding]; other site 697284006742 Switch I region; other site 697284006743 G2 box; other site 697284006744 G3 box; other site 697284006745 Switch II region; other site 697284006746 G4 box; other site 697284006747 G5 box; other site 697284006748 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 697284006749 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 697284006750 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 697284006751 germination protease; Provisional; Region: PRK02858 697284006752 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 697284006753 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 697284006754 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 697284006755 Putative zinc-finger; Region: zf-HC2; pfam13490 697284006756 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 697284006757 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697284006758 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697284006759 DNA binding residues [nucleotide binding] 697284006760 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697284006761 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 697284006762 Walker A/P-loop; other site 697284006763 ATP binding site [chemical binding]; other site 697284006764 Q-loop/lid; other site 697284006765 ABC transporter signature motif; other site 697284006766 Walker B; other site 697284006767 D-loop; other site 697284006768 H-loop/switch region; other site 697284006769 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284006770 MULE transposase domain; Region: MULE; pfam10551 697284006771 FtsX-like permease family; Region: FtsX; pfam02687 697284006772 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284006773 MULE transposase domain; Region: MULE; pfam10551 697284006774 DRTGG domain; Region: DRTGG; pfam07085 697284006775 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 697284006776 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 697284006777 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 697284006778 active site 697284006779 Zn binding site [ion binding]; other site 697284006780 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284006781 MULE transposase domain; Region: MULE; pfam10551 697284006782 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 697284006783 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 697284006784 ribonuclease Z; Region: RNase_Z; TIGR02651 697284006785 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 697284006786 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 697284006787 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 697284006788 substrate binding pocket [chemical binding]; other site 697284006789 dimer interface [polypeptide binding]; other site 697284006790 inhibitor binding site; inhibition site 697284006791 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 697284006792 B12 binding site [chemical binding]; other site 697284006793 cobalt ligand [ion binding]; other site 697284006794 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 697284006795 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 697284006796 Cupin domain; Region: Cupin_2; cl17218 697284006797 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 697284006798 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697284006799 active site 697284006800 motif I; other site 697284006801 motif II; other site 697284006802 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 697284006803 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 697284006804 LexA repressor; Validated; Region: PRK00215 697284006805 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697284006806 putative DNA binding site [nucleotide binding]; other site 697284006807 putative Zn2+ binding site [ion binding]; other site 697284006808 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 697284006809 Catalytic site [active] 697284006810 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 697284006811 Transcriptional regulator [Transcription]; Region: LytR; COG1316 697284006812 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 697284006813 HTH-like domain; Region: HTH_21; pfam13276 697284006814 Integrase core domain; Region: rve; pfam00665 697284006815 Integrase core domain; Region: rve_2; pfam13333 697284006816 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284006817 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284006818 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284006819 Integrase core domain; Region: rve; pfam00665 697284006820 Integrase core domain; Region: rve_3; pfam13683 697284006821 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284006822 MULE transposase domain; Region: MULE; pfam10551 697284006823 HTH-like domain; Region: HTH_21; pfam13276 697284006824 Integrase core domain; Region: rve; pfam00665 697284006825 putative transposase OrfB; Reviewed; Region: PHA02517 697284006826 HTH-like domain; Region: HTH_21; pfam13276 697284006827 Integrase core domain; Region: rve; pfam00665 697284006828 Integrase core domain; Region: rve_3; pfam13683 697284006829 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284006830 Transposase; Region: HTH_Tnp_1; pfam01527 697284006831 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 697284006832 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 697284006833 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 697284006834 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 697284006835 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 697284006836 DNA binding residues [nucleotide binding] 697284006837 putative dimer interface [polypeptide binding]; other site 697284006838 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 697284006839 Aluminium resistance protein; Region: Alum_res; pfam06838 697284006840 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 697284006841 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 697284006842 HflX GTPase family; Region: HflX; cd01878 697284006843 G1 box; other site 697284006844 GTP/Mg2+ binding site [chemical binding]; other site 697284006845 Switch I region; other site 697284006846 G2 box; other site 697284006847 G3 box; other site 697284006848 Switch II region; other site 697284006849 G4 box; other site 697284006850 G5 box; other site 697284006851 stage V sporulation protein K; Region: spore_V_K; TIGR02881 697284006852 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697284006853 Walker A motif; other site 697284006854 ATP binding site [chemical binding]; other site 697284006855 Walker B motif; other site 697284006856 arginine finger; other site 697284006857 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 697284006858 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 697284006859 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 697284006860 Uncharacterized conserved protein [Function unknown]; Region: COG1434 697284006861 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 697284006862 putative active site [active] 697284006863 Esterase/lipase [General function prediction only]; Region: COG1647 697284006864 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 697284006865 active site 697284006866 Transglycosylase; Region: Transgly; pfam00912 697284006867 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 697284006868 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 697284006869 bacterial Hfq-like; Region: Hfq; cd01716 697284006870 hexamer interface [polypeptide binding]; other site 697284006871 Sm1 motif; other site 697284006872 RNA binding site [nucleotide binding]; other site 697284006873 Sm2 motif; other site 697284006874 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 697284006875 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 697284006876 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 697284006877 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 697284006878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284006879 ATP binding site [chemical binding]; other site 697284006880 Mg2+ binding site [ion binding]; other site 697284006881 G-X-G motif; other site 697284006882 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 697284006883 ATP binding site [chemical binding]; other site 697284006884 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 697284006885 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 697284006886 MutS domain I; Region: MutS_I; pfam01624 697284006887 MutS domain II; Region: MutS_II; pfam05188 697284006888 MutS domain III; Region: MutS_III; pfam05192 697284006889 MutS domain V; Region: MutS_V; pfam00488 697284006890 Walker A/P-loop; other site 697284006891 ATP binding site [chemical binding]; other site 697284006892 Q-loop/lid; other site 697284006893 ABC transporter signature motif; other site 697284006894 Walker B; other site 697284006895 D-loop; other site 697284006896 H-loop/switch region; other site 697284006897 Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395 697284006898 Outer spore coat protein E (CotE); Region: CotE; pfam10628 697284006899 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 697284006900 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 697284006901 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 697284006902 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284006903 non-specific DNA binding site [nucleotide binding]; other site 697284006904 salt bridge; other site 697284006905 sequence-specific DNA binding site [nucleotide binding]; other site 697284006906 Streptococcus thermophilus bacteriophage Gp111 protein; Region: Phage_Gp111; pfam07410 697284006907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 697284006908 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 697284006909 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 697284006910 active site 697284006911 metal binding site [ion binding]; metal-binding site 697284006912 Holin family; Region: Phage_holin_4; cl01989 697284006913 XkdW protein; Region: XkdW; pfam09636 697284006914 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 697284006915 Phage tail protein; Region: Sipho_tail; pfam05709 697284006916 Phage tail protein; Region: Sipho_tail; cl17486 697284006917 seryl-tRNA synthetase; Region: serS; TIGR00414 697284006918 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 697284006919 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 697284006920 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 697284006921 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 697284006922 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 697284006923 Homeodomain-like domain; Region: HTH_23; pfam13384 697284006924 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284006925 MULE transposase domain; Region: MULE; pfam10551 697284006926 Helix-turn-helix domain; Region: HTH_36; pfam13730 697284006927 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 697284006928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 697284006929 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 697284006930 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 697284006931 cofactor binding site; other site 697284006932 DNA binding site [nucleotide binding] 697284006933 substrate interaction site [chemical binding]; other site 697284006934 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 697284006935 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 697284006936 hypothetical protein; Provisional; Region: PRK08356 697284006937 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 697284006938 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 697284006939 SprT homologues; Region: SprT; cl01182 697284006940 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 697284006941 trimer interface [polypeptide binding]; other site 697284006942 active site 697284006943 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 697284006944 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 697284006945 dimer interface [polypeptide binding]; other site 697284006946 putative radical transfer pathway; other site 697284006947 diiron center [ion binding]; other site 697284006948 tyrosyl radical; other site 697284006949 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 697284006950 Class I ribonucleotide reductase; Region: RNR_I; cd01679 697284006951 active site 697284006952 dimer interface [polypeptide binding]; other site 697284006953 catalytic residues [active] 697284006954 effector binding site; other site 697284006955 R2 peptide binding site; other site 697284006956 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 697284006957 active site 697284006958 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 697284006959 active site 697284006960 catalytic site [active] 697284006961 substrate binding site [chemical binding]; other site 697284006962 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 697284006963 catalytic site [active] 697284006964 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 697284006965 active site 697284006966 catalytic site [active] 697284006967 substrate binding site [chemical binding]; other site 697284006968 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 697284006969 DNA binding site [nucleotide binding] 697284006970 Uncharacterized protein conserved in archaea (DUF2175); Region: DUF2175; cl02010 697284006971 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 697284006972 active site 697284006973 metal binding site [ion binding]; metal-binding site 697284006974 interdomain interaction site; other site 697284006975 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 697284006976 Walker A motif; other site 697284006977 ATP binding site [chemical binding]; other site 697284006978 Walker B motif; other site 697284006979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 697284006980 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 697284006981 Helix-turn-helix domain; Region: HTH_36; pfam13730 697284006982 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284006983 non-specific DNA binding site [nucleotide binding]; other site 697284006984 salt bridge; other site 697284006985 sequence-specific DNA binding site [nucleotide binding]; other site 697284006986 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284006987 LexA repressor; Validated; Region: PRK00215 697284006988 non-specific DNA binding site [nucleotide binding]; other site 697284006989 salt bridge; other site 697284006990 sequence-specific DNA binding site [nucleotide binding]; other site 697284006991 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 697284006992 Catalytic site [active] 697284006993 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 697284006994 Int/Topo IB signature motif; other site 697284006995 Predicted membrane protein [Function unknown]; Region: COG4129 697284006996 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 697284006997 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 697284006998 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 697284006999 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 697284007000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 697284007001 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284007002 MULE transposase domain; Region: MULE; pfam10551 697284007003 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 697284007004 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 697284007005 active site 697284007006 Zn binding site [ion binding]; other site 697284007007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 697284007008 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 697284007009 active site clefts [active] 697284007010 zinc binding site [ion binding]; other site 697284007011 dimer interface [polypeptide binding]; other site 697284007012 Domain of unknown function (DUF309); Region: DUF309; pfam03745 697284007013 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 697284007014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 697284007015 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 697284007016 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 697284007017 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 697284007018 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697284007019 Coenzyme A binding pocket [chemical binding]; other site 697284007020 malate synthase A; Region: malate_syn_A; TIGR01344 697284007021 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 697284007022 active site 697284007023 isocitrate lyase; Provisional; Region: PRK15063 697284007024 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 697284007025 tetramer interface [polypeptide binding]; other site 697284007026 active site 697284007027 Mg2+/Mn2+ binding site [ion binding]; other site 697284007028 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284007029 MULE transposase domain; Region: MULE; pfam10551 697284007030 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697284007031 DNA-binding site [nucleotide binding]; DNA binding site 697284007032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284007033 Walker A/P-loop; other site 697284007034 ATP binding site [chemical binding]; other site 697284007035 Q-loop/lid; other site 697284007036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284007037 ABC transporter signature motif; other site 697284007038 Walker B; other site 697284007039 D-loop; other site 697284007040 H-loop/switch region; other site 697284007041 Kinase associated protein B; Region: KapB; pfam08810 697284007042 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 697284007043 catalytic residues [active] 697284007044 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 697284007045 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697284007046 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697284007047 ABC transporter; Region: ABC_tran_2; pfam12848 697284007048 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697284007049 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 697284007050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284007051 Walker A/P-loop; other site 697284007052 ATP binding site [chemical binding]; other site 697284007053 Q-loop/lid; other site 697284007054 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697284007055 ABC transporter signature motif; other site 697284007056 Walker B; other site 697284007057 D-loop; other site 697284007058 ABC transporter; Region: ABC_tran_2; pfam12848 697284007059 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697284007060 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 697284007061 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 697284007062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284007063 Walker A/P-loop; other site 697284007064 ATP binding site [chemical binding]; other site 697284007065 Q-loop/lid; other site 697284007066 ABC transporter signature motif; other site 697284007067 Walker B; other site 697284007068 D-loop; other site 697284007069 H-loop/switch region; other site 697284007070 ABC transporter; Region: ABC_tran_2; pfam12848 697284007071 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697284007072 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 697284007073 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 697284007074 phosphopeptide binding site; other site 697284007075 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 697284007076 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 697284007077 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 697284007078 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 697284007079 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 697284007080 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 697284007081 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 697284007082 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 697284007083 Lipopolysaccharide-assembly; Region: LptE; cl01125 697284007084 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 697284007085 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697284007086 dimerization interface [polypeptide binding]; other site 697284007087 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 697284007088 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 697284007089 dimer interface [polypeptide binding]; other site 697284007090 putative CheW interface [polypeptide binding]; other site 697284007091 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 697284007092 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 697284007093 Peptidase family U32; Region: Peptidase_U32; pfam01136 697284007094 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 697284007095 Peptidase family U32; Region: Peptidase_U32; pfam01136 697284007096 YceG-like family; Region: YceG; pfam02618 697284007097 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 697284007098 dimerization interface [polypeptide binding]; other site 697284007099 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 697284007100 hypothetical protein; Provisional; Region: PRK13678 697284007101 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 697284007102 hypothetical protein; Provisional; Region: PRK05473 697284007103 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 697284007104 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 697284007105 motif 1; other site 697284007106 active site 697284007107 motif 2; other site 697284007108 motif 3; other site 697284007109 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 697284007110 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 697284007111 Domain of unknown function DUF20; Region: UPF0118; pfam01594 697284007112 Transcriptional regulators [Transcription]; Region: MarR; COG1846 697284007113 MarR family; Region: MarR; pfam01047 697284007114 MarR family; Region: MarR_2; cl17246 697284007115 PRC-barrel domain; Region: PRC; pfam05239 697284007116 PRC-barrel domain; Region: PRC; pfam05239 697284007117 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 697284007118 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 697284007119 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697284007120 catalytic residue [active] 697284007121 Predicted transcriptional regulator [Transcription]; Region: COG1959 697284007122 Transcriptional regulator; Region: Rrf2; pfam02082 697284007123 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 697284007124 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 697284007125 Ligand Binding Site [chemical binding]; other site 697284007126 recombination factor protein RarA; Reviewed; Region: PRK13342 697284007127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697284007128 Walker A motif; other site 697284007129 ATP binding site [chemical binding]; other site 697284007130 Walker B motif; other site 697284007131 arginine finger; other site 697284007132 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 697284007133 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 697284007134 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 697284007135 putative ATP binding site [chemical binding]; other site 697284007136 putative substrate interface [chemical binding]; other site 697284007137 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 697284007138 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 697284007139 dimer interface [polypeptide binding]; other site 697284007140 anticodon binding site; other site 697284007141 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 697284007142 homodimer interface [polypeptide binding]; other site 697284007143 motif 1; other site 697284007144 active site 697284007145 motif 2; other site 697284007146 GAD domain; Region: GAD; pfam02938 697284007147 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 697284007148 motif 3; other site 697284007149 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 697284007150 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 697284007151 dimer interface [polypeptide binding]; other site 697284007152 motif 1; other site 697284007153 active site 697284007154 motif 2; other site 697284007155 motif 3; other site 697284007156 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 697284007157 anticodon binding site; other site 697284007158 Predicted transcriptional regulators [Transcription]; Region: COG1733 697284007159 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 697284007160 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284007161 MULE transposase domain; Region: MULE; pfam10551 697284007162 multidrug efflux protein; Reviewed; Region: PRK01766 697284007163 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 697284007164 cation binding site [ion binding]; other site 697284007165 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 697284007166 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 697284007167 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 697284007168 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697284007169 FeS/SAM binding site; other site 697284007170 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 697284007171 putative active site [active] 697284007172 dimerization interface [polypeptide binding]; other site 697284007173 putative tRNAtyr binding site [nucleotide binding]; other site 697284007174 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 697284007175 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697284007176 Zn2+ binding site [ion binding]; other site 697284007177 Mg2+ binding site [ion binding]; other site 697284007178 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 697284007179 synthetase active site [active] 697284007180 NTP binding site [chemical binding]; other site 697284007181 metal binding site [ion binding]; metal-binding site 697284007182 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 697284007183 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 697284007184 uracil transporter; Provisional; Region: PRK10720 697284007185 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697284007186 active site 697284007187 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 697284007188 Cation efflux family; Region: Cation_efflux; pfam01545 697284007189 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 697284007190 Protein export membrane protein; Region: SecD_SecF; pfam02355 697284007191 protein-export membrane protein SecD; Region: secD; TIGR01129 697284007192 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 697284007193 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 697284007194 stage V sporulation protein B; Region: spore_V_B; TIGR02900 697284007195 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 697284007196 Predicted membrane protein [Function unknown]; Region: COG2323 697284007197 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 697284007198 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 697284007199 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 697284007200 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 697284007201 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 697284007202 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 697284007203 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 697284007204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697284007205 Walker A motif; other site 697284007206 ATP binding site [chemical binding]; other site 697284007207 Walker B motif; other site 697284007208 arginine finger; other site 697284007209 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 697284007210 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 697284007211 RuvA N terminal domain; Region: RuvA_N; pfam01330 697284007212 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 697284007213 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 697284007214 active site 697284007215 putative DNA-binding cleft [nucleotide binding]; other site 697284007216 dimer interface [polypeptide binding]; other site 697284007217 BofC C-terminal domain; Region: BofC_C; pfam08955 697284007218 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284007219 MULE transposase domain; Region: MULE; pfam10551 697284007220 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 697284007221 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 697284007222 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 697284007223 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 697284007224 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 697284007225 homodimer interface [polypeptide binding]; other site 697284007226 substrate-cofactor binding pocket; other site 697284007227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284007228 catalytic residue [active] 697284007229 prephenate dehydratase; Provisional; Region: PRK11898 697284007230 Prephenate dehydratase; Region: PDT; pfam00800 697284007231 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 697284007232 putative L-Phe binding site [chemical binding]; other site 697284007233 homoserine kinase; Provisional; Region: PRK01212 697284007234 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 697284007235 threonine synthase; Reviewed; Region: PRK06721 697284007236 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 697284007237 homodimer interface [polypeptide binding]; other site 697284007238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284007239 catalytic residue [active] 697284007240 homoserine dehydrogenase; Provisional; Region: PRK06349 697284007241 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 697284007242 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 697284007243 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 697284007244 hypothetical protein; Provisional; Region: PRK04435 697284007245 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 697284007246 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 697284007247 nudix motif; other site 697284007248 GTPase CgtA; Reviewed; Region: obgE; PRK12297 697284007249 GTP1/OBG; Region: GTP1_OBG; pfam01018 697284007250 Obg GTPase; Region: Obg; cd01898 697284007251 G1 box; other site 697284007252 GTP/Mg2+ binding site [chemical binding]; other site 697284007253 Switch I region; other site 697284007254 G2 box; other site 697284007255 G3 box; other site 697284007256 Switch II region; other site 697284007257 G4 box; other site 697284007258 G5 box; other site 697284007259 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 697284007260 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 697284007261 Protein of unknown function (DUF464); Region: DUF464; pfam04327 697284007262 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 697284007263 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 697284007264 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 697284007265 oligonucleotide binding site [chemical binding]; other site 697284007266 homodimer interface [polypeptide binding]; other site 697284007267 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 697284007268 Peptidase family M50; Region: Peptidase_M50; pfam02163 697284007269 active site 697284007270 putative substrate binding region [chemical binding]; other site 697284007271 CBS domain; Region: CBS; pfam00571 697284007272 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 697284007273 Peptidase family M23; Region: Peptidase_M23; pfam01551 697284007274 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 697284007275 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 697284007276 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 697284007277 Switch I; other site 697284007278 Switch II; other site 697284007279 septum formation inhibitor; Reviewed; Region: minC; PRK00513 697284007280 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 697284007281 rod shape-determining protein MreD; Region: MreD; cl01087 697284007282 rod shape-determining protein MreC; Provisional; Region: PRK13922 697284007283 rod shape-determining protein MreC; Region: MreC; pfam04085 697284007284 rod shape-determining protein MreB; Provisional; Region: PRK13927 697284007285 MreB and similar proteins; Region: MreB_like; cd10225 697284007286 nucleotide binding site [chemical binding]; other site 697284007287 Mg binding site [ion binding]; other site 697284007288 putative protofilament interaction site [polypeptide binding]; other site 697284007289 RodZ interaction site [polypeptide binding]; other site 697284007290 hypothetical protein; Reviewed; Region: PRK00024 697284007291 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 697284007292 MPN+ (JAMM) motif; other site 697284007293 Zinc-binding site [ion binding]; other site 697284007294 Predicted transcriptional regulator [Transcription]; Region: COG1959 697284007295 Transcriptional regulator; Region: Rrf2; pfam02082 697284007296 Transcriptional regulator; Region: Rrf2; cl17282 697284007297 Maf-like protein; Reviewed; Region: PRK00078 697284007298 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 697284007299 active site 697284007300 dimer interface [polypeptide binding]; other site 697284007301 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 697284007302 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 697284007303 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 697284007304 active site 697284007305 metal binding site [ion binding]; metal-binding site 697284007306 S-layer homology domain; Region: SLH; pfam00395 697284007307 S-layer homology domain; Region: SLH; pfam00395 697284007308 S-layer homology domain; Region: SLH; pfam00395 697284007309 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 697284007310 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 697284007311 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 697284007312 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 697284007313 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 697284007314 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 697284007315 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 697284007316 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 697284007317 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 697284007318 active site 697284007319 HIGH motif; other site 697284007320 nucleotide binding site [chemical binding]; other site 697284007321 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 697284007322 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 697284007323 active site 697284007324 KMSKS motif; other site 697284007325 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 697284007326 tRNA binding surface [nucleotide binding]; other site 697284007327 anticodon binding site; other site 697284007328 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 697284007329 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 697284007330 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 697284007331 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 697284007332 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 697284007333 active site 697284007334 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 697284007335 pantothenate kinase; Provisional; Region: PRK05439 697284007336 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 697284007337 ATP-binding site [chemical binding]; other site 697284007338 CoA-binding site [chemical binding]; other site 697284007339 Mg2+-binding site [ion binding]; other site 697284007340 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 697284007341 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 697284007342 inhibitor-cofactor binding pocket; inhibition site 697284007343 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284007344 catalytic residue [active] 697284007345 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 697284007346 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 697284007347 ferrochelatase; Provisional; Region: PRK12435 697284007348 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 697284007349 C-terminal domain interface [polypeptide binding]; other site 697284007350 active site 697284007351 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 697284007352 active site 697284007353 N-terminal domain interface [polypeptide binding]; other site 697284007354 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 697284007355 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 697284007356 substrate binding site [chemical binding]; other site 697284007357 active site 697284007358 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 697284007359 dimer interface [polypeptide binding]; other site 697284007360 active site 697284007361 Schiff base residues; other site 697284007362 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 697284007363 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 697284007364 active site 697284007365 SAM binding site [chemical binding]; other site 697284007366 homodimer interface [polypeptide binding]; other site 697284007367 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 697284007368 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 697284007369 active site 697284007370 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 697284007371 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 697284007372 domain interfaces; other site 697284007373 active site 697284007374 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 697284007375 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 697284007376 Cytochrome C assembly protein; Region: Cytochrom_C_asm; pfam01578 697284007377 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 697284007378 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 697284007379 tRNA; other site 697284007380 putative tRNA binding site [nucleotide binding]; other site 697284007381 putative NADP binding site [chemical binding]; other site 697284007382 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 697284007383 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 697284007384 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 697284007385 G1 box; other site 697284007386 GTP/Mg2+ binding site [chemical binding]; other site 697284007387 Switch I region; other site 697284007388 G2 box; other site 697284007389 G3 box; other site 697284007390 Switch II region; other site 697284007391 G4 box; other site 697284007392 G5 box; other site 697284007393 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 697284007394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697284007395 Walker A motif; other site 697284007396 ATP binding site [chemical binding]; other site 697284007397 Walker B motif; other site 697284007398 arginine finger; other site 697284007399 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 697284007400 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 697284007401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697284007402 Walker A motif; other site 697284007403 ATP binding site [chemical binding]; other site 697284007404 Walker B motif; other site 697284007405 arginine finger; other site 697284007406 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 697284007407 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 697284007408 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 697284007409 active site 697284007410 metal binding site [ion binding]; metal-binding site 697284007411 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 697284007412 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 697284007413 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 697284007414 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 697284007415 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 697284007416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697284007417 Walker A motif; other site 697284007418 ATP binding site [chemical binding]; other site 697284007419 Walker B motif; other site 697284007420 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 697284007421 Clp protease; Region: CLP_protease; pfam00574 697284007422 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 697284007423 oligomer interface [polypeptide binding]; other site 697284007424 active site residues [active] 697284007425 trigger factor; Provisional; Region: tig; PRK01490 697284007426 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 697284007427 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 697284007428 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 697284007429 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 697284007430 putative active site [active] 697284007431 putative metal binding site [ion binding]; other site 697284007432 Predicted membrane protein [Function unknown]; Region: COG3428 697284007433 Bacterial PH domain; Region: DUF304; pfam03703 697284007434 Bacterial PH domain; Region: DUF304; pfam03703 697284007435 Bacterial PH domain; Region: DUF304; pfam03703 697284007436 Uncharacterized conserved protein [Function unknown]; Region: COG3402 697284007437 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 697284007438 active site 697284007439 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 697284007440 dimer interface [polypeptide binding]; other site 697284007441 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 697284007442 Ligand Binding Site [chemical binding]; other site 697284007443 Molecular Tunnel; other site 697284007444 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 697284007445 active site 697284007446 dimerization interface [polypeptide binding]; other site 697284007447 ribonuclease PH; Reviewed; Region: rph; PRK00173 697284007448 Ribonuclease PH; Region: RNase_PH_bact; cd11362 697284007449 hexamer interface [polypeptide binding]; other site 697284007450 active site 697284007451 Sporulation and spore germination; Region: Germane; pfam10646 697284007452 Spore germination protein [General function prediction only]; Region: COG5401 697284007453 Sporulation and spore germination; Region: Germane; pfam10646 697284007454 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 697284007455 tetramer interfaces [polypeptide binding]; other site 697284007456 binuclear metal-binding site [ion binding]; other site 697284007457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284007458 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284007459 MULE transposase domain; Region: MULE; pfam10551 697284007460 Leucine carboxyl methyltransferase; Region: LCM; cl01306 697284007461 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 697284007462 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 697284007463 amidase catalytic site [active] 697284007464 Zn binding residues [ion binding]; other site 697284007465 substrate binding site [chemical binding]; other site 697284007466 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 697284007467 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284007468 MULE transposase domain; Region: MULE; pfam10551 697284007469 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 697284007470 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 697284007471 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 697284007472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 697284007473 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 697284007474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284007475 S-adenosylmethionine binding site [chemical binding]; other site 697284007476 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 697284007477 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 697284007478 NAD binding site [chemical binding]; other site 697284007479 dimer interface [polypeptide binding]; other site 697284007480 tetramer (dimer of dimers) interface [polypeptide binding]; other site 697284007481 substrate binding site [chemical binding]; other site 697284007482 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284007483 MULE transposase domain; Region: MULE; pfam10551 697284007484 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 697284007485 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 697284007486 DNA binding residues [nucleotide binding] 697284007487 dimerization interface [polypeptide binding]; other site 697284007488 putative uracil/xanthine transporter; Provisional; Region: PRK11412 697284007489 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 697284007490 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 697284007491 heterodimer interface [polypeptide binding]; other site 697284007492 active site 697284007493 FMN binding site [chemical binding]; other site 697284007494 homodimer interface [polypeptide binding]; other site 697284007495 substrate binding site [chemical binding]; other site 697284007496 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 697284007497 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 697284007498 FAD binding pocket [chemical binding]; other site 697284007499 FAD binding motif [chemical binding]; other site 697284007500 phosphate binding motif [ion binding]; other site 697284007501 beta-alpha-beta structure motif; other site 697284007502 NAD binding pocket [chemical binding]; other site 697284007503 Iron coordination center [ion binding]; other site 697284007504 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 697284007505 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 697284007506 dimer interface [polypeptide binding]; other site 697284007507 active site 697284007508 CoA binding pocket [chemical binding]; other site 697284007509 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 697284007510 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 697284007511 Probable Catalytic site; other site 697284007512 metal-binding site 697284007513 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 697284007514 active site 697284007515 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 697284007516 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 697284007517 active site 697284007518 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 697284007519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697284007520 NAD(P) binding site [chemical binding]; other site 697284007521 active site 697284007522 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 697284007523 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 697284007524 active site 697284007525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697284007526 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 697284007527 NAD(P) binding site [chemical binding]; other site 697284007528 active site 697284007529 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 697284007530 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 697284007531 NADP binding site [chemical binding]; other site 697284007532 active site 697284007533 putative substrate binding site [chemical binding]; other site 697284007534 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 697284007535 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 697284007536 NAD(P) binding site [chemical binding]; other site 697284007537 homodimer interface [polypeptide binding]; other site 697284007538 substrate binding site [chemical binding]; other site 697284007539 active site 697284007540 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 697284007541 active site 697284007542 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 697284007543 homodimer interface [polypeptide binding]; other site 697284007544 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 697284007545 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 697284007546 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 697284007547 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 697284007548 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 697284007549 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 697284007550 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 697284007551 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 697284007552 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 697284007553 active site 697284007554 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 697284007555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 697284007556 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 697284007557 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 697284007558 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 697284007559 putative transposase OrfB; Reviewed; Region: PHA02517 697284007560 HTH-like domain; Region: HTH_21; pfam13276 697284007561 Integrase core domain; Region: rve; pfam00665 697284007562 Integrase core domain; Region: rve_2; pfam13333 697284007563 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284007564 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284007565 Transposase; Region: HTH_Tnp_1; cl17663 697284007566 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 697284007567 GAF domain; Region: GAF_2; pfam13185 697284007568 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 697284007569 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697284007570 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 697284007571 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697284007572 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 697284007573 Malic enzyme, N-terminal domain; Region: malic; pfam00390 697284007574 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 697284007575 putative NAD(P) binding site [chemical binding]; other site 697284007576 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 697284007577 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 697284007578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284007579 homodimer interface [polypeptide binding]; other site 697284007580 catalytic residue [active] 697284007581 Homeodomain-like domain; Region: HTH_23; pfam13384 697284007582 Winged helix-turn helix; Region: HTH_29; pfam13551 697284007583 Winged helix-turn helix; Region: HTH_33; pfam13592 697284007584 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697284007585 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 697284007586 S-layer homology domain; Region: SLH; pfam00395 697284007587 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 697284007588 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 697284007589 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 697284007590 DEAD-like helicases superfamily; Region: DEXDc; smart00487 697284007591 ATP binding site [chemical binding]; other site 697284007592 Mg++ binding site [ion binding]; other site 697284007593 motif III; other site 697284007594 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697284007595 nucleotide binding region [chemical binding]; other site 697284007596 ATP-binding site [chemical binding]; other site 697284007597 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 697284007598 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697284007599 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697284007600 DNA binding residues [nucleotide binding] 697284007601 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 697284007602 Uncharacterized protein family (UPF0180); Region: UPF0180; pfam03698 697284007603 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 697284007604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697284007605 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 697284007606 NAD(P) binding site [chemical binding]; other site 697284007607 active site 697284007608 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 697284007609 PAS domain S-box; Region: sensory_box; TIGR00229 697284007610 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 697284007611 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 697284007612 putative active site [active] 697284007613 heme pocket [chemical binding]; other site 697284007614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697284007615 dimer interface [polypeptide binding]; other site 697284007616 phosphorylation site [posttranslational modification] 697284007617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284007618 ATP binding site [chemical binding]; other site 697284007619 Mg2+ binding site [ion binding]; other site 697284007620 G-X-G motif; other site 697284007621 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 697284007622 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697284007623 active site 697284007624 motif I; other site 697284007625 motif II; other site 697284007626 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697284007627 Transcriptional regulator [Transcription]; Region: LysR; COG0583 697284007628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 697284007629 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 697284007630 dimerization interface [polypeptide binding]; other site 697284007631 histidinol-phosphatase; Provisional; Region: PRK07328 697284007632 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 697284007633 active site 697284007634 dimer interface [polypeptide binding]; other site 697284007635 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 697284007636 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 697284007637 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 697284007638 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 697284007639 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 697284007640 L-aspartate oxidase; Provisional; Region: PRK06175 697284007641 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 697284007642 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 697284007643 putative Iron-sulfur protein interface [polypeptide binding]; other site 697284007644 proximal heme binding site [chemical binding]; other site 697284007645 distal heme binding site [chemical binding]; other site 697284007646 putative dimer interface [polypeptide binding]; other site 697284007647 Transcriptional regulator [Transcription]; Region: LysR; COG0583 697284007648 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 697284007649 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 697284007650 dimerization interface [polypeptide binding]; other site 697284007651 potassium/proton antiporter; Reviewed; Region: PRK05326 697284007652 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 697284007653 TrkA-N domain; Region: TrkA_N; pfam02254 697284007654 TrkA-C domain; Region: TrkA_C; pfam02080 697284007655 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 697284007656 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 697284007657 CAAX protease self-immunity; Region: Abi; pfam02517 697284007658 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 697284007659 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 697284007660 GIY-YIG motif/motif A; other site 697284007661 active site 697284007662 catalytic site [active] 697284007663 putative DNA binding site [nucleotide binding]; other site 697284007664 metal binding site [ion binding]; metal-binding site 697284007665 UvrB/uvrC motif; Region: UVR; pfam02151 697284007666 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 697284007667 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 697284007668 catalytic residues [active] 697284007669 YqzM-like protein; Region: YqzM; pfam14141 697284007670 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 697284007671 heme-binding site [chemical binding]; other site 697284007672 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 697284007673 dimer interface [polypeptide binding]; other site 697284007674 putative CheW interface [polypeptide binding]; other site 697284007675 primosomal protein DnaI; Reviewed; Region: PRK08939 697284007676 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 697284007677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697284007678 Walker A motif; other site 697284007679 ATP binding site [chemical binding]; other site 697284007680 Walker B motif; other site 697284007681 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 697284007682 Putative membrane protein; Region: YuiB; pfam14068 697284007683 putative heme peroxidase; Provisional; Region: PRK12276 697284007684 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 697284007685 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 697284007686 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 697284007687 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 697284007688 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 697284007689 Sporulation inhibitor A; Region: Sda; pfam08970 697284007690 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 697284007691 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 697284007692 DsrE/DsrF-like family; Region: DrsE; cl00672 697284007693 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 697284007694 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 697284007695 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 697284007696 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 697284007697 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 697284007698 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 697284007699 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 697284007700 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697284007701 FeS/SAM binding site; other site 697284007702 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 697284007703 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 697284007704 hypothetical protein; Provisional; Region: PRK13669 697284007705 NifU-like domain; Region: NifU; cl00484 697284007706 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 697284007707 classical (c) SDRs; Region: SDR_c; cd05233 697284007708 NAD(P) binding site [chemical binding]; other site 697284007709 active site 697284007710 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 697284007711 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 697284007712 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 697284007713 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 697284007714 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 697284007715 catalytic residues [active] 697284007716 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 697284007717 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 697284007718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 697284007719 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 697284007720 stage V sporulation protein B; Region: spore_V_B; TIGR02900 697284007721 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 697284007722 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 697284007723 conserved cys residue [active] 697284007724 Protein of unknown function (DUF456); Region: DUF456; pfam04306 697284007725 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 697284007726 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697284007727 active site 697284007728 motif I; other site 697284007729 motif II; other site 697284007730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697284007731 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 697284007732 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 697284007733 active site 697284007734 dimer interface [polypeptide binding]; other site 697284007735 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 697284007736 Ligand Binding Site [chemical binding]; other site 697284007737 Molecular Tunnel; other site 697284007738 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284007739 MULE transposase domain; Region: MULE; pfam10551 697284007740 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 697284007741 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 697284007742 Homeodomain-like domain; Region: HTH_23; pfam13384 697284007743 Winged helix-turn helix; Region: HTH_29; pfam13551 697284007744 Winged helix-turn helix; Region: HTH_33; pfam13592 697284007745 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697284007746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 697284007747 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 697284007748 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 697284007749 LrgA family; Region: LrgA; cl00608 697284007750 Transcriptional regulator [Transcription]; Region: LysR; COG0583 697284007751 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 697284007752 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 697284007753 putative dimerization interface [polypeptide binding]; other site 697284007754 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 697284007755 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 697284007756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284007757 Major Facilitator Superfamily; Region: MFS_1; pfam07690 697284007758 putative substrate translocation pore; other site 697284007759 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 697284007760 active site 697284007761 metal binding site [ion binding]; metal-binding site 697284007762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 697284007763 HTH-like domain; Region: HTH_21; pfam13276 697284007764 Integrase core domain; Region: rve; pfam00665 697284007765 Integrase core domain; Region: rve_2; pfam13333 697284007766 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284007767 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284007768 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284007769 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 697284007770 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 697284007771 Cu(I) binding site [ion binding]; other site 697284007772 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 697284007773 UbiA prenyltransferase family; Region: UbiA; pfam01040 697284007774 Cache domain; Region: Cache_1; pfam02743 697284007775 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 697284007776 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 697284007777 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 697284007778 dimer interface [polypeptide binding]; other site 697284007779 putative CheW interface [polypeptide binding]; other site 697284007780 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 697284007781 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 697284007782 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 697284007783 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 697284007784 active site 697284007785 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 697284007786 HIGH motif; other site 697284007787 dimer interface [polypeptide binding]; other site 697284007788 KMSKS motif; other site 697284007789 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 697284007790 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 697284007791 catalytic triad [active] 697284007792 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 697284007793 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 697284007794 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 697284007795 RNA/DNA hybrid binding site [nucleotide binding]; other site 697284007796 active site 697284007797 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284007798 MULE transposase domain; Region: MULE; pfam10551 697284007799 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 697284007800 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 697284007801 active site 697284007802 Zn binding site [ion binding]; other site 697284007803 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 697284007804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 697284007805 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 697284007806 apolar tunnel; other site 697284007807 heme binding site [chemical binding]; other site 697284007808 dimerization interface [polypeptide binding]; other site 697284007809 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 697284007810 Nucleoside recognition; Region: Gate; pfam07670 697284007811 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 697284007812 ATP-NAD kinase; Region: NAD_kinase; pfam01513 697284007813 Transposase domain (DUF772); Region: DUF772; pfam05598 697284007814 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 697284007815 lipoyl synthase; Provisional; Region: PRK05481 697284007816 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697284007817 FeS/SAM binding site; other site 697284007818 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 697284007819 Peptidase family M23; Region: Peptidase_M23; pfam01551 697284007820 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 697284007821 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 697284007822 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 697284007823 nucleotide binding site [chemical binding]; other site 697284007824 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284007825 MULE transposase domain; Region: MULE; pfam10551 697284007826 HTH-like domain; Region: HTH_21; pfam13276 697284007827 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 697284007828 Integrase core domain; Region: rve; pfam00665 697284007829 Integrase core domain; Region: rve_2; pfam13333 697284007830 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284007831 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284007832 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284007833 Transposase; Region: HTH_Tnp_1; cl17663 697284007834 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284007835 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 697284007836 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 697284007837 dimer interface [polypeptide binding]; other site 697284007838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284007839 catalytic residue [active] 697284007840 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 697284007841 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 697284007842 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 697284007843 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 697284007844 TrkA-N domain; Region: TrkA_N; pfam02254 697284007845 TrkA-C domain; Region: TrkA_C; pfam02080 697284007846 Small, acid-soluble spore protein I; Region: SSPI; cl07940 697284007847 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 697284007848 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 697284007849 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 697284007850 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 697284007851 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 697284007852 G1 box; other site 697284007853 putative GEF interaction site [polypeptide binding]; other site 697284007854 GTP/Mg2+ binding site [chemical binding]; other site 697284007855 Switch I region; other site 697284007856 G2 box; other site 697284007857 G3 box; other site 697284007858 Switch II region; other site 697284007859 G4 box; other site 697284007860 G5 box; other site 697284007861 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 697284007862 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 697284007863 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 697284007864 active site 697284007865 metal binding site [ion binding]; metal-binding site 697284007866 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697284007867 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 697284007868 Walker A/P-loop; other site 697284007869 ATP binding site [chemical binding]; other site 697284007870 Q-loop/lid; other site 697284007871 ABC transporter signature motif; other site 697284007872 Walker B; other site 697284007873 D-loop; other site 697284007874 H-loop/switch region; other site 697284007875 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 697284007876 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 697284007877 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 697284007878 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 697284007879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284007880 dimer interface [polypeptide binding]; other site 697284007881 conserved gate region; other site 697284007882 ABC-ATPase subunit interface; other site 697284007883 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 697284007884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284007885 dimer interface [polypeptide binding]; other site 697284007886 conserved gate region; other site 697284007887 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 697284007888 ABC-ATPase subunit interface; other site 697284007889 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 697284007890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284007891 active site 697284007892 phosphorylation site [posttranslational modification] 697284007893 intermolecular recognition site; other site 697284007894 dimerization interface [polypeptide binding]; other site 697284007895 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697284007896 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 697284007897 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697284007898 dimerization interface [polypeptide binding]; other site 697284007899 Histidine kinase; Region: His_kinase; pfam06580 697284007900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284007901 ATP binding site [chemical binding]; other site 697284007902 Mg2+ binding site [ion binding]; other site 697284007903 G-X-G motif; other site 697284007904 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 697284007905 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 697284007906 active site 697284007907 catalytic site [active] 697284007908 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 697284007909 Uncharacterized conserved protein [Function unknown]; Region: COG3538 697284007910 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 697284007911 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 697284007912 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 697284007913 active site 697284007914 metal binding site [ion binding]; metal-binding site 697284007915 homodimer interface [polypeptide binding]; other site 697284007916 catalytic site [active] 697284007917 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 697284007918 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 697284007919 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 697284007920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284007921 ATP binding site [chemical binding]; other site 697284007922 Mg2+ binding site [ion binding]; other site 697284007923 G-X-G motif; other site 697284007924 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697284007925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284007926 active site 697284007927 phosphorylation site [posttranslational modification] 697284007928 intermolecular recognition site; other site 697284007929 dimerization interface [polypeptide binding]; other site 697284007930 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697284007931 DNA binding site [nucleotide binding] 697284007932 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 697284007933 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 697284007934 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 697284007935 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697284007936 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 697284007937 Coenzyme A binding pocket [chemical binding]; other site 697284007938 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 697284007939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284007940 active site 697284007941 phosphorylation site [posttranslational modification] 697284007942 intermolecular recognition site; other site 697284007943 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 697284007944 DNA binding residues [nucleotide binding] 697284007945 dimerization interface [polypeptide binding]; other site 697284007946 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 697284007947 Histidine kinase; Region: HisKA_3; pfam07730 697284007948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284007949 ATP binding site [chemical binding]; other site 697284007950 Mg2+ binding site [ion binding]; other site 697284007951 G-X-G motif; other site 697284007952 Predicted membrane protein [Function unknown]; Region: COG4758 697284007953 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 697284007954 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 697284007955 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697284007956 FeS/SAM binding site; other site 697284007957 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 697284007958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 697284007959 MOSC domain; Region: MOSC; pfam03473 697284007960 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284007961 MULE transposase domain; Region: MULE; pfam10551 697284007962 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284007963 MULE transposase domain; Region: MULE; pfam10551 697284007964 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 697284007965 TAP-like protein; Region: Abhydrolase_4; pfam08386 697284007966 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 697284007967 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 697284007968 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 697284007969 active site 697284007970 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 697284007971 metal binding site 2 [ion binding]; metal-binding site 697284007972 putative DNA binding helix; other site 697284007973 metal binding site 1 [ion binding]; metal-binding site 697284007974 dimer interface [polypeptide binding]; other site 697284007975 structural Zn2+ binding site [ion binding]; other site 697284007976 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 697284007977 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697284007978 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697284007979 DNA binding residues [nucleotide binding] 697284007980 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 697284007981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697284007982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 697284007983 Coenzyme A binding pocket [chemical binding]; other site 697284007984 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 697284007985 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 697284007986 GatB domain; Region: GatB_Yqey; smart00845 697284007987 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 697284007988 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 697284007989 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 697284007990 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 697284007991 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 697284007992 active site 697284007993 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 697284007994 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 697284007995 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 697284007996 nitrosocyanin; Region: nitroso_cyanin; TIGR03096 697284007997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 697284007998 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 697284007999 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008000 MULE transposase domain; Region: MULE; pfam10551 697284008001 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 697284008002 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 697284008003 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 697284008004 NodB motif; other site 697284008005 active site 697284008006 catalytic site [active] 697284008007 metal binding site [ion binding]; metal-binding site 697284008008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 697284008009 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 697284008010 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 697284008011 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 697284008012 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 697284008013 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008014 MULE transposase domain; Region: MULE; pfam10551 697284008015 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 697284008016 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 697284008017 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 697284008018 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 697284008019 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 697284008020 active site 697284008021 zinc binding site [ion binding]; other site 697284008022 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 697284008023 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 697284008024 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 697284008025 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 697284008026 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 697284008027 putative active site [active] 697284008028 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 697284008029 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 697284008030 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 697284008031 putative active site [active] 697284008032 catalytic site [active] 697284008033 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 697284008034 putative active site [active] 697284008035 catalytic site [active] 697284008036 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 697284008037 Catalytic site; other site 697284008038 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 697284008039 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 697284008040 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 697284008041 putative active site [active] 697284008042 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 697284008043 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 697284008044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284008045 homodimer interface [polypeptide binding]; other site 697284008046 catalytic residue [active] 697284008047 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 697284008048 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 697284008049 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 697284008050 active site turn [active] 697284008051 phosphorylation site [posttranslational modification] 697284008052 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 697284008053 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 697284008054 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 697284008055 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 697284008056 HTH-like domain; Region: HTH_21; pfam13276 697284008057 Integrase core domain; Region: rve; pfam00665 697284008058 Integrase core domain; Region: rve_2; pfam13333 697284008059 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284008060 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284008061 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284008062 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008063 MULE transposase domain; Region: MULE; pfam10551 697284008064 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 697284008065 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 697284008066 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 697284008067 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 697284008068 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697284008069 catalytic residue [active] 697284008070 Domain of unknown function (DUF4310); Region: DUF4310; pfam14187 697284008071 Domain of unknown function (DUF4311); Region: DUF4311; pfam14188 697284008072 Domain of unknown function (DUF4312); Region: DUF4312; pfam14189 697284008073 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 697284008074 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 697284008075 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008076 MULE transposase domain; Region: MULE; pfam10551 697284008077 ABC-2 type transporter; Region: ABC2_membrane; cl17235 697284008078 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 697284008079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284008080 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 697284008081 Walker A/P-loop; other site 697284008082 ATP binding site [chemical binding]; other site 697284008083 Q-loop/lid; other site 697284008084 ABC transporter signature motif; other site 697284008085 Walker B; other site 697284008086 D-loop; other site 697284008087 H-loop/switch region; other site 697284008088 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 697284008089 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 697284008090 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 697284008091 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008092 MULE transposase domain; Region: MULE; pfam10551 697284008093 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 697284008094 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 697284008095 Ligand binding site; other site 697284008096 Putative Catalytic site; other site 697284008097 DXD motif; other site 697284008098 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 697284008099 dimer interface [polypeptide binding]; other site 697284008100 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 697284008101 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 697284008102 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697284008103 DNA binding site [nucleotide binding] 697284008104 domain linker motif; other site 697284008105 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 697284008106 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 697284008107 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 697284008108 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 697284008109 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 697284008110 Glutamate binding site [chemical binding]; other site 697284008111 homodimer interface [polypeptide binding]; other site 697284008112 NAD binding site [chemical binding]; other site 697284008113 catalytic residues [active] 697284008114 Proline dehydrogenase; Region: Pro_dh; cl03282 697284008115 Stage II sporulation protein; Region: SpoIID; pfam08486 697284008116 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 697284008117 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 697284008118 active site 697284008119 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 697284008120 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 697284008121 Catalytic site [active] 697284008122 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 697284008123 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 697284008124 active site 697284008125 DNA binding site [nucleotide binding] 697284008126 Int/Topo IB signature motif; other site 697284008127 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 697284008128 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697284008129 Zn2+ binding site [ion binding]; other site 697284008130 Mg2+ binding site [ion binding]; other site 697284008131 Predicted permeases [General function prediction only]; Region: RarD; COG2962 697284008132 EamA-like transporter family; Region: EamA; cl17759 697284008133 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008134 MULE transposase domain; Region: MULE; pfam10551 697284008135 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 697284008136 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697284008137 Zn2+ binding site [ion binding]; other site 697284008138 Mg2+ binding site [ion binding]; other site 697284008139 CCC1-related family of proteins; Region: CCC1_like; cd01059 697284008140 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 697284008141 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 697284008142 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 697284008143 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 697284008144 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 697284008145 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 697284008146 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 697284008147 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 697284008148 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 697284008149 putative dimer interface [polypeptide binding]; other site 697284008150 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 697284008151 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 697284008152 Predicted transcriptional regulator [Transcription]; Region: COG2345 697284008153 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697284008154 dimerization interface [polypeptide binding]; other site 697284008155 putative DNA binding site [nucleotide binding]; other site 697284008156 putative Zn2+ binding site [ion binding]; other site 697284008157 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 697284008158 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 697284008159 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 697284008160 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008161 MULE transposase domain; Region: MULE; pfam10551 697284008162 alpha-mannosidase; Provisional; Region: PRK09819 697284008163 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 697284008164 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 697284008165 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 697284008166 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 697284008167 Transcriptional regulator [Transcription]; Region: LysR; COG0583 697284008168 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 697284008169 dimerization interface [polypeptide binding]; other site 697284008170 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 697284008171 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 697284008172 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 697284008173 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 697284008174 active site 697284008175 dimer interface [polypeptide binding]; other site 697284008176 effector binding site; other site 697284008177 TSCPD domain; Region: TSCPD; pfam12637 697284008178 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 697284008179 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 697284008180 homodimer interface [polypeptide binding]; other site 697284008181 substrate-cofactor binding pocket; other site 697284008182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284008183 catalytic residue [active] 697284008184 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 697284008185 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 697284008186 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697284008187 ATP binding site [chemical binding]; other site 697284008188 putative Mg++ binding site [ion binding]; other site 697284008189 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697284008190 nucleotide binding region [chemical binding]; other site 697284008191 ATP-binding site [chemical binding]; other site 697284008192 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 697284008193 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 697284008194 YqzE-like protein; Region: YqzE; pfam14038 697284008195 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284008196 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284008197 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284008198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 697284008199 HTH-like domain; Region: HTH_21; pfam13276 697284008200 Integrase core domain; Region: rve; pfam00665 697284008201 Integrase core domain; Region: rve_2; pfam13333 697284008202 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 697284008203 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 697284008204 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 697284008205 DinB superfamily; Region: DinB_2; pfam12867 697284008206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 697284008207 YheO-like PAS domain; Region: PAS_6; pfam08348 697284008208 HTH domain; Region: HTH_22; pfam13309 697284008209 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 697284008210 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 697284008211 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 697284008212 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 697284008213 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 697284008214 putative L-serine binding site [chemical binding]; other site 697284008215 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 697284008216 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 697284008217 Walker A/P-loop; other site 697284008218 ATP binding site [chemical binding]; other site 697284008219 Q-loop/lid; other site 697284008220 ABC transporter signature motif; other site 697284008221 Walker B; other site 697284008222 D-loop; other site 697284008223 H-loop/switch region; other site 697284008224 Cobalt transport protein; Region: CbiQ; cl00463 697284008225 ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930 697284008226 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 697284008227 active site 697284008228 SAM binding site [chemical binding]; other site 697284008229 homodimer interface [polypeptide binding]; other site 697284008230 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 697284008231 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 697284008232 active site 697284008233 C-terminal domain interface [polypeptide binding]; other site 697284008234 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 697284008235 active site 697284008236 N-terminal domain interface [polypeptide binding]; other site 697284008237 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 697284008238 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 697284008239 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 697284008240 active site 697284008241 SAM binding site [chemical binding]; other site 697284008242 homodimer interface [polypeptide binding]; other site 697284008243 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 697284008244 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 697284008245 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 697284008246 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 697284008247 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 697284008248 active site 697284008249 SAM binding site [chemical binding]; other site 697284008250 homodimer interface [polypeptide binding]; other site 697284008251 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 697284008252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284008253 S-adenosylmethionine binding site [chemical binding]; other site 697284008254 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 697284008255 active site 697284008256 putative homodimer interface [polypeptide binding]; other site 697284008257 SAM binding site [chemical binding]; other site 697284008258 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 697284008259 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 697284008260 Precorrin-8X methylmutase; Region: CbiC; pfam02570 697284008261 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008262 MULE transposase domain; Region: MULE; pfam10551 697284008263 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 697284008264 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697284008265 FeS/SAM binding site; other site 697284008266 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 697284008267 Accessory gene regulator B; Region: AgrB; pfam04647 697284008268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284008269 active site 697284008270 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 697284008271 phosphorylation site [posttranslational modification] 697284008272 intermolecular recognition site; other site 697284008273 dimerization interface [polypeptide binding]; other site 697284008274 LytTr DNA-binding domain; Region: LytTR; pfam04397 697284008275 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 697284008276 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 697284008277 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 697284008278 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697284008279 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 697284008280 Probable transposase; Region: OrfB_IS605; pfam01385 697284008281 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 697284008282 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 697284008283 Transposase IS200 like; Region: Y1_Tnp; pfam01797 697284008284 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 697284008285 DNA binding site [nucleotide binding] 697284008286 active site 697284008287 Int/Topo IB signature motif; other site 697284008288 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 697284008289 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008290 MULE transposase domain; Region: MULE; pfam10551 697284008291 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 697284008292 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 697284008293 active site turn [active] 697284008294 phosphorylation site [posttranslational modification] 697284008295 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 697284008296 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 697284008297 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 697284008298 putative active site [active] 697284008299 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697284008300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 697284008301 Homeodomain-like domain; Region: HTH_23; pfam13384 697284008302 Winged helix-turn helix; Region: HTH_29; pfam13551 697284008303 Winged helix-turn helix; Region: HTH_33; pfam13592 697284008304 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008305 MULE transposase domain; Region: MULE; pfam10551 697284008306 Uncharacterized conserved protein [Function unknown]; Region: COG3589 697284008307 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 697284008308 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 697284008309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284008310 active site 697284008311 phosphorylation site [posttranslational modification] 697284008312 intermolecular recognition site; other site 697284008313 dimerization interface [polypeptide binding]; other site 697284008314 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 697284008315 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 697284008316 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 697284008317 protein binding site [polypeptide binding]; other site 697284008318 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 697284008319 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 697284008320 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 697284008321 Walker A/P-loop; other site 697284008322 ATP binding site [chemical binding]; other site 697284008323 Q-loop/lid; other site 697284008324 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 697284008325 ABC transporter signature motif; other site 697284008326 Walker B; other site 697284008327 D-loop; other site 697284008328 H-loop/switch region; other site 697284008329 arginine repressor; Provisional; Region: PRK04280 697284008330 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 697284008331 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 697284008332 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 697284008333 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697284008334 RNA binding surface [nucleotide binding]; other site 697284008335 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 697284008336 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 697284008337 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 697284008338 TPP-binding site; other site 697284008339 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 697284008340 PYR/PP interface [polypeptide binding]; other site 697284008341 dimer interface [polypeptide binding]; other site 697284008342 TPP binding site [chemical binding]; other site 697284008343 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 697284008344 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 697284008345 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 697284008346 substrate binding pocket [chemical binding]; other site 697284008347 chain length determination region; other site 697284008348 substrate-Mg2+ binding site; other site 697284008349 catalytic residues [active] 697284008350 aspartate-rich region 1; other site 697284008351 active site lid residues [active] 697284008352 aspartate-rich region 2; other site 697284008353 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 697284008354 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 697284008355 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 697284008356 generic binding surface II; other site 697284008357 generic binding surface I; other site 697284008358 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 697284008359 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 697284008360 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 697284008361 homodimer interface [polypeptide binding]; other site 697284008362 NADP binding site [chemical binding]; other site 697284008363 substrate binding site [chemical binding]; other site 697284008364 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 697284008365 putative RNA binding site [nucleotide binding]; other site 697284008366 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 697284008367 Tetraspanin family; Region: Tetraspannin; pfam00335 697284008368 Asp23 family; Region: Asp23; pfam03780 697284008369 Asp23 family; Region: Asp23; pfam03780 697284008370 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 697284008371 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 697284008372 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 697284008373 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 697284008374 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 697284008375 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 697284008376 carboxyltransferase (CT) interaction site; other site 697284008377 biotinylation site [posttranslational modification]; other site 697284008378 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 697284008379 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 697284008380 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 697284008381 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 697284008382 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 697284008383 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 697284008384 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 697284008385 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 697284008386 NTPase; Region: NTPase_1; cl17478 697284008387 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 697284008388 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 697284008389 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 697284008390 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 697284008391 Protein of unknown function (DUF441); Region: DUF441; pfam04284 697284008392 aspartate kinase; Reviewed; Region: PRK06635 697284008393 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 697284008394 putative nucleotide binding site [chemical binding]; other site 697284008395 putative catalytic residues [active] 697284008396 putative Mg ion binding site [ion binding]; other site 697284008397 putative aspartate binding site [chemical binding]; other site 697284008398 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 697284008399 putative allosteric regulatory site; other site 697284008400 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 697284008401 elongation factor P; Validated; Region: PRK00529 697284008402 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 697284008403 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 697284008404 RNA binding site [nucleotide binding]; other site 697284008405 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 697284008406 RNA binding site [nucleotide binding]; other site 697284008407 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 697284008408 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 697284008409 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 697284008410 active site 697284008411 Dehydroquinase class II; Region: DHquinase_II; pfam01220 697284008412 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 697284008413 trimer interface [polypeptide binding]; other site 697284008414 active site 697284008415 dimer interface [polypeptide binding]; other site 697284008416 Conserved membrane protein YqhR; Region: YqhR; pfam11085 697284008417 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 697284008418 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 697284008419 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 697284008420 active site 697284008421 nucleophile elbow; other site 697284008422 manganese transport transcriptional regulator; Provisional; Region: PRK03902 697284008423 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 697284008424 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 697284008425 Uncharacterized conserved protein [Function unknown]; Region: COG1284 697284008426 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 697284008427 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 697284008428 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 697284008429 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697284008430 FeS/SAM binding site; other site 697284008431 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 697284008432 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 697284008433 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 697284008434 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 697284008435 ABC-ATPase subunit interface; other site 697284008436 dimer interface [polypeptide binding]; other site 697284008437 putative PBP binding regions; other site 697284008438 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697284008439 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 697284008440 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 697284008441 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 697284008442 metal binding site [ion binding]; metal-binding site 697284008443 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 697284008444 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 697284008445 active site 697284008446 HIGH motif; other site 697284008447 KMSKS motif; other site 697284008448 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 697284008449 tRNA binding surface [nucleotide binding]; other site 697284008450 anticodon binding site; other site 697284008451 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 697284008452 dimer interface [polypeptide binding]; other site 697284008453 putative tRNA-binding site [nucleotide binding]; other site 697284008454 Haemolytic domain; Region: Haemolytic; pfam01809 697284008455 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 697284008456 metal binding site 2 [ion binding]; metal-binding site 697284008457 putative DNA binding helix; other site 697284008458 metal binding site 1 [ion binding]; metal-binding site 697284008459 dimer interface [polypeptide binding]; other site 697284008460 structural Zn2+ binding site [ion binding]; other site 697284008461 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 697284008462 Spore germination protein; Region: Spore_permease; cl17796 697284008463 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 697284008464 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 697284008465 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 697284008466 NodB motif; other site 697284008467 putative active site [active] 697284008468 putative catalytic site [active] 697284008469 Zn binding site [ion binding]; other site 697284008470 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 697284008471 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 697284008472 NAD(P) binding site [chemical binding]; other site 697284008473 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 697284008474 amino acid carrier protein; Region: agcS; TIGR00835 697284008475 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 697284008476 putative active site [active] 697284008477 putative metal binding site [ion binding]; other site 697284008478 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 697284008479 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 697284008480 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 697284008481 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 697284008482 putative active site [active] 697284008483 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 697284008484 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 697284008485 Cysteine-rich domain; Region: CCG; pfam02754 697284008486 Cysteine-rich domain; Region: CCG; pfam02754 697284008487 FAD binding domain; Region: FAD_binding_4; pfam01565 697284008488 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 697284008489 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008490 MULE transposase domain; Region: MULE; pfam10551 697284008491 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 697284008492 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 697284008493 dimerization interface [polypeptide binding]; other site 697284008494 DPS ferroxidase diiron center [ion binding]; other site 697284008495 ion pore; other site 697284008496 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697284008497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284008498 active site 697284008499 phosphorylation site [posttranslational modification] 697284008500 intermolecular recognition site; other site 697284008501 dimerization interface [polypeptide binding]; other site 697284008502 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697284008503 DNA binding site [nucleotide binding] 697284008504 glycyl-tRNA synthetase; Provisional; Region: PRK04173 697284008505 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 697284008506 motif 1; other site 697284008507 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 697284008508 active site 697284008509 motif 2; other site 697284008510 motif 3; other site 697284008511 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 697284008512 anticodon binding site; other site 697284008513 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 697284008514 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 697284008515 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 697284008516 nucleotide binding site [chemical binding]; other site 697284008517 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697284008518 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697284008519 DNA binding site [nucleotide binding] 697284008520 domain linker motif; other site 697284008521 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 697284008522 dimerization interface [polypeptide binding]; other site 697284008523 ligand binding site [chemical binding]; other site 697284008524 Sulfatase; Region: Sulfatase; pfam00884 697284008525 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008526 MULE transposase domain; Region: MULE; pfam10551 697284008527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 697284008528 HTH-like domain; Region: HTH_21; pfam13276 697284008529 Integrase core domain; Region: rve; pfam00665 697284008530 Integrase core domain; Region: rve_2; pfam13333 697284008531 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284008532 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284008533 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284008534 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 697284008535 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 697284008536 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 697284008537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284008538 putative substrate translocation pore; other site 697284008539 Transcriptional regulators [Transcription]; Region: FadR; COG2186 697284008540 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697284008541 DNA-binding site [nucleotide binding]; DNA binding site 697284008542 FCD domain; Region: FCD; pfam07729 697284008543 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 697284008544 YhhN-like protein; Region: YhhN; pfam07947 697284008545 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 697284008546 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697284008547 motif II; other site 697284008548 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008549 MULE transposase domain; Region: MULE; pfam10551 697284008550 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008551 MULE transposase domain; Region: MULE; pfam10551 697284008552 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 697284008553 Transposase; Region: HTH_Tnp_1; cl17663 697284008554 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 697284008555 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 697284008556 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 697284008557 active site 697284008558 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 697284008559 hypothetical protein; Provisional; Region: PRK10481 697284008560 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 697284008561 Protein of unknown function (DUF917); Region: DUF917; pfam06032 697284008562 Transcriptional regulator [Transcription]; Region: IclR; COG1414 697284008563 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 697284008564 Bacterial transcriptional regulator; Region: IclR; pfam01614 697284008565 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 697284008566 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 697284008567 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 697284008568 Walker A/P-loop; other site 697284008569 ATP binding site [chemical binding]; other site 697284008570 Q-loop/lid; other site 697284008571 ABC transporter signature motif; other site 697284008572 Walker B; other site 697284008573 D-loop; other site 697284008574 H-loop/switch region; other site 697284008575 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 697284008576 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 697284008577 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 697284008578 Walker A/P-loop; other site 697284008579 ATP binding site [chemical binding]; other site 697284008580 Q-loop/lid; other site 697284008581 ABC transporter signature motif; other site 697284008582 Walker B; other site 697284008583 D-loop; other site 697284008584 H-loop/switch region; other site 697284008585 BioY family; Region: BioY; pfam02632 697284008586 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 697284008587 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 697284008588 active site 697284008589 FMN binding site [chemical binding]; other site 697284008590 substrate binding site [chemical binding]; other site 697284008591 homotetramer interface [polypeptide binding]; other site 697284008592 catalytic residue [active] 697284008593 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 697284008594 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 697284008595 DNA binding residues [nucleotide binding] 697284008596 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 697284008597 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 697284008598 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 697284008599 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 697284008600 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 697284008601 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 697284008602 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 697284008603 active site turn [active] 697284008604 phosphorylation site [posttranslational modification] 697284008605 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 697284008606 HPr interaction site; other site 697284008607 glycerol kinase (GK) interaction site [polypeptide binding]; other site 697284008608 active site 697284008609 phosphorylation site [posttranslational modification] 697284008610 CAT RNA binding domain; Region: CAT_RBD; smart01061 697284008611 transcriptional antiterminator BglG; Provisional; Region: PRK09772 697284008612 PRD domain; Region: PRD; pfam00874 697284008613 PRD domain; Region: PRD; pfam00874 697284008614 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 697284008615 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 697284008616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284008617 dimer interface [polypeptide binding]; other site 697284008618 conserved gate region; other site 697284008619 putative PBP binding loops; other site 697284008620 ABC-ATPase subunit interface; other site 697284008621 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 697284008622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284008623 dimer interface [polypeptide binding]; other site 697284008624 conserved gate region; other site 697284008625 putative PBP binding loops; other site 697284008626 ABC-ATPase subunit interface; other site 697284008627 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 697284008628 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 697284008629 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 697284008630 ATP cone domain; Region: ATP-cone; pfam03477 697284008631 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 697284008632 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 697284008633 N-acetyl-D-glucosamine binding site [chemical binding]; other site 697284008634 catalytic residue [active] 697284008635 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 697284008636 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 697284008637 CoA-binding site [chemical binding]; other site 697284008638 ATP-binding [chemical binding]; other site 697284008639 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 697284008640 Domain of unknown function DUF; Region: DUF204; pfam02659 697284008641 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 697284008642 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 697284008643 DNA binding site [nucleotide binding] 697284008644 catalytic residue [active] 697284008645 H2TH interface [polypeptide binding]; other site 697284008646 putative catalytic residues [active] 697284008647 turnover-facilitating residue; other site 697284008648 intercalation triad [nucleotide binding]; other site 697284008649 8OG recognition residue [nucleotide binding]; other site 697284008650 putative reading head residues; other site 697284008651 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 697284008652 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 697284008653 DNA polymerase I; Provisional; Region: PRK05755 697284008654 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 697284008655 active site 697284008656 metal binding site 1 [ion binding]; metal-binding site 697284008657 putative 5' ssDNA interaction site; other site 697284008658 metal binding site 3; metal-binding site 697284008659 metal binding site 2 [ion binding]; metal-binding site 697284008660 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 697284008661 putative DNA binding site [nucleotide binding]; other site 697284008662 putative metal binding site [ion binding]; other site 697284008663 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 697284008664 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 697284008665 active site 697284008666 DNA binding site [nucleotide binding] 697284008667 catalytic site [active] 697284008668 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 697284008669 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697284008670 active site 697284008671 motif II; other site 697284008672 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 697284008673 Protein of unknown function (DUF1516); Region: DUF1516; pfam07457 697284008674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284008675 putative substrate translocation pore; other site 697284008676 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 697284008677 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008678 MULE transposase domain; Region: MULE; pfam10551 697284008679 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 697284008680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284008681 dimer interface [polypeptide binding]; other site 697284008682 conserved gate region; other site 697284008683 putative PBP binding loops; other site 697284008684 ABC-ATPase subunit interface; other site 697284008685 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 697284008686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284008687 dimer interface [polypeptide binding]; other site 697284008688 conserved gate region; other site 697284008689 putative PBP binding loops; other site 697284008690 ABC-ATPase subunit interface; other site 697284008691 PBP superfamily domain; Region: PBP_like_2; cl17296 697284008692 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 697284008693 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 697284008694 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 697284008695 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 697284008696 Cupin domain; Region: Cupin_2; pfam07883 697284008697 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 697284008698 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697284008699 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697284008700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284008701 active site 697284008702 phosphorylation site [posttranslational modification] 697284008703 intermolecular recognition site; other site 697284008704 dimerization interface [polypeptide binding]; other site 697284008705 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697284008706 DNA binding site [nucleotide binding] 697284008707 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697284008708 dimerization interface [polypeptide binding]; other site 697284008709 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 697284008710 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 697284008711 putative active site [active] 697284008712 heme pocket [chemical binding]; other site 697284008713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697284008714 dimer interface [polypeptide binding]; other site 697284008715 phosphorylation site [posttranslational modification] 697284008716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284008717 ATP binding site [chemical binding]; other site 697284008718 Mg2+ binding site [ion binding]; other site 697284008719 G-X-G motif; other site 697284008720 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 697284008721 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 697284008722 Fumarase C-terminus; Region: Fumerase_C; pfam05683 697284008723 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 697284008724 putative active site [active] 697284008725 putative metal binding site [ion binding]; other site 697284008726 malate dehydrogenase; Reviewed; Region: PRK06223 697284008727 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 697284008728 NAD(P) binding site [chemical binding]; other site 697284008729 dimer interface [polypeptide binding]; other site 697284008730 tetramer (dimer of dimers) interface [polypeptide binding]; other site 697284008731 substrate binding site [chemical binding]; other site 697284008732 isocitrate dehydrogenase; Validated; Region: PRK06451 697284008733 isocitrate dehydrogenase; Reviewed; Region: PRK07006 697284008734 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 697284008735 dimer interface [polypeptide binding]; other site 697284008736 Citrate synthase; Region: Citrate_synt; pfam00285 697284008737 active site 697284008738 citrylCoA binding site [chemical binding]; other site 697284008739 oxalacetate/citrate binding site [chemical binding]; other site 697284008740 coenzyme A binding site [chemical binding]; other site 697284008741 catalytic triad [active] 697284008742 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 697284008743 active site 697284008744 pyruvate kinase; Provisional; Region: PRK06354 697284008745 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 697284008746 active site 697284008747 domain interfaces; other site 697284008748 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 697284008749 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 697284008750 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 697284008751 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 697284008752 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 697284008753 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 697284008754 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 697284008755 active site 697284008756 PHP Thumb interface [polypeptide binding]; other site 697284008757 metal binding site [ion binding]; metal-binding site 697284008758 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 697284008759 generic binding surface II; other site 697284008760 generic binding surface I; other site 697284008761 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 697284008762 Probable transposase; Region: OrfB_IS605; pfam01385 697284008763 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008764 MULE transposase domain; Region: MULE; pfam10551 697284008765 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 697284008766 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 697284008767 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 697284008768 NlpC/P60 family; Region: NLPC_P60; pfam00877 697284008769 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008770 MULE transposase domain; Region: MULE; pfam10551 697284008771 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 697284008772 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008773 MULE transposase domain; Region: MULE; pfam10551 697284008774 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cd00385 697284008775 substrate binding pocket [chemical binding]; other site 697284008776 aspartate-rich region 2; other site 697284008777 substrate-Mg2+ binding site; other site 697284008778 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 697284008779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284008780 active site 697284008781 phosphorylation site [posttranslational modification] 697284008782 intermolecular recognition site; other site 697284008783 dimerization interface [polypeptide binding]; other site 697284008784 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 697284008785 DNA binding residues [nucleotide binding] 697284008786 dimerization interface [polypeptide binding]; other site 697284008787 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 697284008788 Histidine kinase; Region: HisKA_3; pfam07730 697284008789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284008790 ATP binding site [chemical binding]; other site 697284008791 Mg2+ binding site [ion binding]; other site 697284008792 G-X-G motif; other site 697284008793 YtpI-like protein; Region: YtpI; pfam14007 697284008794 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 697284008795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 697284008796 DNA-binding site [nucleotide binding]; DNA binding site 697284008797 DRTGG domain; Region: DRTGG; pfam07085 697284008798 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 697284008799 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008800 MULE transposase domain; Region: MULE; pfam10551 697284008801 hypothetical protein; Provisional; Region: PRK13676 697284008802 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 697284008803 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 697284008804 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 697284008805 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 697284008806 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 697284008807 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 697284008808 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 697284008809 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 697284008810 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 697284008811 Ligand binding site; other site 697284008812 Putative Catalytic site; other site 697284008813 DXD motif; other site 697284008814 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008815 MULE transposase domain; Region: MULE; pfam10551 697284008816 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284008817 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284008818 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284008819 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 697284008820 HTH-like domain; Region: HTH_21; pfam13276 697284008821 Integrase core domain; Region: rve; pfam00665 697284008822 Integrase core domain; Region: rve_2; pfam13333 697284008823 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 697284008824 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 697284008825 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 697284008826 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 697284008827 active site 697284008828 catalytic triad [active] 697284008829 S-layer homology domain; Region: SLH; pfam00395 697284008830 S-layer homology domain; Region: SLH; pfam00395 697284008831 S-layer homology domain; Region: SLH; pfam00395 697284008832 LytTr DNA-binding domain; Region: LytTR; pfam04397 697284008833 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 697284008834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 697284008835 putative active site [active] 697284008836 heme pocket [chemical binding]; other site 697284008837 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697284008838 dimer interface [polypeptide binding]; other site 697284008839 phosphorylation site [posttranslational modification] 697284008840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284008841 ATP binding site [chemical binding]; other site 697284008842 Mg2+ binding site [ion binding]; other site 697284008843 G-X-G motif; other site 697284008844 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 697284008845 SpoVR like protein; Region: SpoVR; pfam04293 697284008846 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 697284008847 ABC transporter; Region: ABC_tran; pfam00005 697284008848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284008849 ABC transporter signature motif; other site 697284008850 Walker B; other site 697284008851 D-loop; other site 697284008852 H-loop/switch region; other site 697284008853 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008854 MULE transposase domain; Region: MULE; pfam10551 697284008855 Integral membrane protein DUF95; Region: DUF95; pfam01944 697284008856 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008857 MULE transposase domain; Region: MULE; pfam10551 697284008858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284008859 Transposase; Region: HTH_Tnp_1; pfam01527 697284008860 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 697284008861 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 697284008862 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697284008863 motif II; other site 697284008864 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 697284008865 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 697284008866 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 697284008867 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 697284008868 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 697284008869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697284008870 dimer interface [polypeptide binding]; other site 697284008871 conserved gate region; other site 697284008872 putative PBP binding loops; other site 697284008873 ABC-ATPase subunit interface; other site 697284008874 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 697284008875 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 697284008876 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284008877 MULE transposase domain; Region: MULE; pfam10551 697284008878 DNA binding domain, excisionase family; Region: excise; TIGR01764 697284008879 PBP superfamily domain; Region: PBP_like; pfam12727 697284008880 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 697284008881 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 697284008882 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 697284008883 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697284008884 catalytic residue [active] 697284008885 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 697284008886 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 697284008887 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 697284008888 MgtC family; Region: MgtC; pfam02308 697284008889 glutamine synthetase, type I; Region: GlnA; TIGR00653 697284008890 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 697284008891 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 697284008892 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 697284008893 intersubunit interface [polypeptide binding]; other site 697284008894 active site 697284008895 catalytic residue [active] 697284008896 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 697284008897 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 697284008898 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 697284008899 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 697284008900 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 697284008901 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 697284008902 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 697284008903 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 697284008904 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 697284008905 non-specific DNA interactions [nucleotide binding]; other site 697284008906 DNA binding site [nucleotide binding] 697284008907 sequence specific DNA binding site [nucleotide binding]; other site 697284008908 putative cAMP binding site [chemical binding]; other site 697284008909 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 697284008910 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 697284008911 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 697284008912 CLUSTERIN alpha chain; Region: CLa; smart00035 697284008913 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 697284008914 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697284008915 dimerization interface [polypeptide binding]; other site 697284008916 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697284008917 dimer interface [polypeptide binding]; other site 697284008918 phosphorylation site [posttranslational modification] 697284008919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284008920 ATP binding site [chemical binding]; other site 697284008921 Mg2+ binding site [ion binding]; other site 697284008922 G-X-G motif; other site 697284008923 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697284008924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284008925 active site 697284008926 phosphorylation site [posttranslational modification] 697284008927 intermolecular recognition site; other site 697284008928 dimerization interface [polypeptide binding]; other site 697284008929 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697284008930 DNA binding site [nucleotide binding] 697284008931 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 697284008932 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 697284008933 protein binding site [polypeptide binding]; other site 697284008934 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 697284008935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284008936 active site 697284008937 phosphorylation site [posttranslational modification] 697284008938 intermolecular recognition site; other site 697284008939 dimerization interface [polypeptide binding]; other site 697284008940 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 697284008941 DNA binding residues [nucleotide binding] 697284008942 dimerization interface [polypeptide binding]; other site 697284008943 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697284008944 dimerization interface [polypeptide binding]; other site 697284008945 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 697284008946 Histidine kinase; Region: HisKA_3; pfam07730 697284008947 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284008948 ATP binding site [chemical binding]; other site 697284008949 Mg2+ binding site [ion binding]; other site 697284008950 G-X-G motif; other site 697284008951 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 697284008952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 697284008953 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 697284008954 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 697284008955 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 697284008956 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 697284008957 active site 697284008958 dimer interface [polypeptide binding]; other site 697284008959 motif 1; other site 697284008960 motif 2; other site 697284008961 motif 3; other site 697284008962 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 697284008963 anticodon binding site; other site 697284008964 YtxC-like family; Region: YtxC; pfam08812 697284008965 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 697284008966 active site 697284008967 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 697284008968 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697284008969 FeS/SAM binding site; other site 697284008970 cystathionine beta-lyase; Provisional; Region: PRK08064 697284008971 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 697284008972 homodimer interface [polypeptide binding]; other site 697284008973 substrate-cofactor binding pocket; other site 697284008974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284008975 catalytic residue [active] 697284008976 cystathionine gamma-synthase; Reviewed; Region: PRK08247 697284008977 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 697284008978 homodimer interface [polypeptide binding]; other site 697284008979 substrate-cofactor binding pocket; other site 697284008980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284008981 catalytic residue [active] 697284008982 Homoserine O-succinyltransferase; Region: HTS; pfam04204 697284008983 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 697284008984 proposed active site lysine [active] 697284008985 conserved cys residue [active] 697284008986 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 697284008987 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 697284008988 oligomer interface [polypeptide binding]; other site 697284008989 metal binding site [ion binding]; metal-binding site 697284008990 metal binding site [ion binding]; metal-binding site 697284008991 putative Cl binding site [ion binding]; other site 697284008992 aspartate ring; other site 697284008993 hydrophobic gate; other site 697284008994 periplasmic entrance; other site 697284008995 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 697284008996 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 697284008997 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 697284008998 HRDC domain; Region: HRDC; pfam00570 697284008999 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 697284009000 Virus attachment protein p12 family; Region: P12; pfam12669 697284009001 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 697284009002 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 697284009003 G1 box; other site 697284009004 GTP/Mg2+ binding site [chemical binding]; other site 697284009005 Switch I region; other site 697284009006 G2 box; other site 697284009007 G3 box; other site 697284009008 Switch II region; other site 697284009009 G4 box; other site 697284009010 G5 box; other site 697284009011 Nucleoside recognition; Region: Gate; pfam07670 697284009012 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 697284009013 Nucleoside recognition; Region: Gate; pfam07670 697284009014 FeoA domain; Region: FeoA; pfam04023 697284009015 Predicted membrane protein [Function unknown]; Region: COG2322 697284009016 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 697284009017 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 697284009018 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 697284009019 5'-3' exonuclease; Region: 53EXOc; smart00475 697284009020 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 697284009021 active site 697284009022 metal binding site 1 [ion binding]; metal-binding site 697284009023 putative 5' ssDNA interaction site; other site 697284009024 metal binding site 3; metal-binding site 697284009025 metal binding site 2 [ion binding]; metal-binding site 697284009026 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 697284009027 putative DNA binding site [nucleotide binding]; other site 697284009028 putative metal binding site [ion binding]; other site 697284009029 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 697284009030 MarR family; Region: MarR; pfam01047 697284009031 MarR family; Region: MarR_2; cl17246 697284009032 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284009033 MULE transposase domain; Region: MULE; pfam10551 697284009034 Predicted integral membrane protein [Function unknown]; Region: COG5542 697284009035 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 697284009036 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 697284009037 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 697284009038 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 697284009039 active site 697284009040 catalytic tetrad [active] 697284009041 DNA-sulfur modification-associated; Region: DndB; cl17621 697284009042 DGQHR domain; Region: DGQHR; TIGR03187 697284009043 DNA-sulfur modification-associated; Region: DndB; cl17621 697284009044 DGQHR domain; Region: DGQHR; TIGR03187 697284009045 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 697284009046 active site 697284009047 putative substrate binding region [chemical binding]; other site 697284009048 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 697284009049 ArsC family; Region: ArsC; pfam03960 697284009050 putative ArsC-like catalytic residues; other site 697284009051 putative TRX-like catalytic residues [active] 697284009052 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 697284009053 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 697284009054 active site 697284009055 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 697284009056 cobyric acid synthase; Provisional; Region: PRK00784 697284009057 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 697284009058 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 697284009059 catalytic triad [active] 697284009060 cobalamin synthase; Reviewed; Region: cobS; PRK00235 697284009061 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 697284009062 homotrimer interface [polypeptide binding]; other site 697284009063 Walker A motif; other site 697284009064 GTP binding site [chemical binding]; other site 697284009065 Walker B motif; other site 697284009066 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 697284009067 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 697284009068 putative dimer interface [polypeptide binding]; other site 697284009069 active site pocket [active] 697284009070 putative cataytic base [active] 697284009071 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 697284009072 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 697284009073 Walker A/P-loop; other site 697284009074 ATP binding site [chemical binding]; other site 697284009075 Q-loop/lid; other site 697284009076 ABC transporter signature motif; other site 697284009077 Walker B; other site 697284009078 D-loop; other site 697284009079 H-loop/switch region; other site 697284009080 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 697284009081 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 697284009082 ABC-ATPase subunit interface; other site 697284009083 dimer interface [polypeptide binding]; other site 697284009084 putative PBP binding regions; other site 697284009085 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 697284009086 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 697284009087 intersubunit interface [polypeptide binding]; other site 697284009088 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 697284009089 hypothetical protein; Validated; Region: PRK07682 697284009090 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 697284009091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284009092 homodimer interface [polypeptide binding]; other site 697284009093 catalytic residue [active] 697284009094 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 697284009095 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 697284009096 AsnC family; Region: AsnC_trans_reg; pfam01037 697284009097 Major Facilitator Superfamily; Region: MFS_1; pfam07690 697284009098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284009099 putative substrate translocation pore; other site 697284009100 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 697284009101 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 697284009102 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 697284009103 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 697284009104 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 697284009105 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 697284009106 MutS domain III; Region: MutS_III; pfam05192 697284009107 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 697284009108 Walker A/P-loop; other site 697284009109 ATP binding site [chemical binding]; other site 697284009110 Q-loop/lid; other site 697284009111 ABC transporter signature motif; other site 697284009112 Walker B; other site 697284009113 D-loop; other site 697284009114 H-loop/switch region; other site 697284009115 Smr domain; Region: Smr; pfam01713 697284009116 Membrane protein of unknown function; Region: DUF360; pfam04020 697284009117 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 697284009118 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 697284009119 Colicin V production protein; Region: Colicin_V; pfam02674 697284009120 Cell division protein ZapA; Region: ZapA; cl01146 697284009121 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 697284009122 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 697284009123 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 697284009124 putative tRNA-binding site [nucleotide binding]; other site 697284009125 B3/4 domain; Region: B3_4; pfam03483 697284009126 tRNA synthetase B5 domain; Region: B5; smart00874 697284009127 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 697284009128 dimer interface [polypeptide binding]; other site 697284009129 motif 1; other site 697284009130 motif 3; other site 697284009131 motif 2; other site 697284009132 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 697284009133 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 697284009134 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 697284009135 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 697284009136 dimer interface [polypeptide binding]; other site 697284009137 motif 1; other site 697284009138 active site 697284009139 motif 2; other site 697284009140 motif 3; other site 697284009141 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 697284009142 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 697284009143 Catalytic site [active] 697284009144 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 697284009145 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 697284009146 active site 697284009147 catalytic tetrad [active] 697284009148 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 697284009149 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284009150 Integrase core domain; Region: rve; pfam00665 697284009151 Integrase core domain; Region: rve_3; pfam13683 697284009152 HTH-like domain; Region: HTH_21; pfam13276 697284009153 Integrase core domain; Region: rve; pfam00665 697284009154 Helix-turn-helix domain; Region: HTH_28; pfam13518 697284009155 Winged helix-turn helix; Region: HTH_29; pfam13551 697284009156 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284009157 MULE transposase domain; Region: MULE; pfam10551 697284009158 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697284009159 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697284009160 DNA binding site [nucleotide binding] 697284009161 domain linker motif; other site 697284009162 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 697284009163 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 697284009164 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 697284009165 substrate binding site [chemical binding]; other site 697284009166 dimer interface [polypeptide binding]; other site 697284009167 ATP binding site [chemical binding]; other site 697284009168 D-ribose pyranase; Provisional; Region: PRK11797 697284009169 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 697284009170 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 697284009171 Walker A/P-loop; other site 697284009172 ATP binding site [chemical binding]; other site 697284009173 Q-loop/lid; other site 697284009174 ABC transporter signature motif; other site 697284009175 Walker B; other site 697284009176 D-loop; other site 697284009177 H-loop/switch region; other site 697284009178 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 697284009179 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 697284009180 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 697284009181 TM-ABC transporter signature motif; other site 697284009182 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 697284009183 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 697284009184 ligand binding site [chemical binding]; other site 697284009185 dimerization interface [polypeptide binding]; other site 697284009186 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284009187 MULE transposase domain; Region: MULE; pfam10551 697284009188 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 697284009189 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284009190 MULE transposase domain; Region: MULE; pfam10551 697284009191 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 697284009192 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 697284009193 active site 697284009194 DNA binding site [nucleotide binding] 697284009195 Int/Topo IB signature motif; other site 697284009196 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 697284009197 DDE superfamily endonuclease; Region: DDE_3; pfam13358 697284009198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 697284009199 Homeodomain-like domain; Region: HTH_23; pfam13384 697284009200 Winged helix-turn helix; Region: HTH_29; pfam13551 697284009201 Winged helix-turn helix; Region: HTH_33; pfam13592 697284009202 HTH-like domain; Region: HTH_21; pfam13276 697284009203 Integrase core domain; Region: rve; pfam00665 697284009204 Predicted membrane protein [Function unknown]; Region: COG2311 697284009205 Protein of unknown function (DUF418); Region: DUF418; pfam04235 697284009206 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 697284009207 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 697284009208 ligand binding site [chemical binding]; other site 697284009209 flexible hinge region; other site 697284009210 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 697284009211 putative switch regulator; other site 697284009212 non-specific DNA interactions [nucleotide binding]; other site 697284009213 DNA binding site [nucleotide binding] 697284009214 sequence specific DNA binding site [nucleotide binding]; other site 697284009215 putative cAMP binding site [chemical binding]; other site 697284009216 Rubredoxin [Energy production and conversion]; Region: COG1773 697284009217 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 697284009218 iron binding site [ion binding]; other site 697284009219 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 697284009220 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 697284009221 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 697284009222 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284009223 MULE transposase domain; Region: MULE; pfam10551 697284009224 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 697284009225 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 697284009226 Hemerythrin-like domain; Region: Hr-like; cd12108 697284009227 Fe binding site [ion binding]; other site 697284009228 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284009229 MULE transposase domain; Region: MULE; pfam10551 697284009230 CopC domain; Region: CopC; pfam04234 697284009231 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 697284009232 Mor transcription activator family; Region: Mor; cl02360 697284009233 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 697284009234 Histidine kinase; Region: HisKA_3; pfam07730 697284009235 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 697284009236 Mg2+ binding site [ion binding]; other site 697284009237 G-X-G motif; other site 697284009238 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 697284009239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284009240 active site 697284009241 phosphorylation site [posttranslational modification] 697284009242 intermolecular recognition site; other site 697284009243 dimerization interface [polypeptide binding]; other site 697284009244 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 697284009245 DNA binding residues [nucleotide binding] 697284009246 dimerization interface [polypeptide binding]; other site 697284009247 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 697284009248 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 697284009249 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 697284009250 metal-binding site [ion binding] 697284009251 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 697284009252 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 697284009253 metal-binding site [ion binding] 697284009254 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 697284009255 Soluble P-type ATPase [General function prediction only]; Region: COG4087 697284009256 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 697284009257 metal-binding site [ion binding] 697284009258 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 697284009259 putative homodimer interface [polypeptide binding]; other site 697284009260 putative homotetramer interface [polypeptide binding]; other site 697284009261 allosteric switch controlling residues; other site 697284009262 putative metal binding site [ion binding]; other site 697284009263 putative homodimer-homodimer interface [polypeptide binding]; other site 697284009264 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 697284009265 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 697284009266 folate binding site [chemical binding]; other site 697284009267 NADP+ binding site [chemical binding]; other site 697284009268 thymidylate synthase; Region: thym_sym; TIGR03284 697284009269 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 697284009270 dimerization interface [polypeptide binding]; other site 697284009271 active site 697284009272 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 697284009273 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 697284009274 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 697284009275 Ligand Binding Site [chemical binding]; other site 697284009276 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 697284009277 lipoyl attachment site [posttranslational modification]; other site 697284009278 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 697284009279 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 697284009280 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 697284009281 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 697284009282 tetramer interface [polypeptide binding]; other site 697284009283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284009284 catalytic residue [active] 697284009285 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 697284009286 tetramer interface [polypeptide binding]; other site 697284009287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284009288 catalytic residue [active] 697284009289 PAS domain; Region: PAS; smart00091 697284009290 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 697284009291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697284009292 dimer interface [polypeptide binding]; other site 697284009293 phosphorylation site [posttranslational modification] 697284009294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284009295 ATP binding site [chemical binding]; other site 697284009296 Mg2+ binding site [ion binding]; other site 697284009297 G-X-G motif; other site 697284009298 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 697284009299 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 697284009300 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697284009301 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284009302 MULE transposase domain; Region: MULE; pfam10551 697284009303 KTSC domain; Region: KTSC; pfam13619 697284009304 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 697284009305 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 697284009306 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 697284009307 lipoyl attachment site [posttranslational modification]; other site 697284009308 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 697284009309 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 697284009310 dimer interface [polypeptide binding]; other site 697284009311 decamer (pentamer of dimers) interface [polypeptide binding]; other site 697284009312 catalytic triad [active] 697284009313 peroxidatic and resolving cysteines [active] 697284009314 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 697284009315 tartrate dehydrogenase; Region: TTC; TIGR02089 697284009316 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 697284009317 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 697284009318 Walker A/P-loop; other site 697284009319 ATP binding site [chemical binding]; other site 697284009320 Q-loop/lid; other site 697284009321 ABC transporter signature motif; other site 697284009322 Walker B; other site 697284009323 D-loop; other site 697284009324 H-loop/switch region; other site 697284009325 Integral membrane protein DUF95; Region: DUF95; cl00572 697284009326 2-isopropylmalate synthase; Validated; Region: PRK00915 697284009327 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 697284009328 active site 697284009329 catalytic residues [active] 697284009330 metal binding site [ion binding]; metal-binding site 697284009331 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 697284009332 ketol-acid reductoisomerase; Provisional; Region: PRK05479 697284009333 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 697284009334 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 697284009335 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 697284009336 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 697284009337 putative valine binding site [chemical binding]; other site 697284009338 dimer interface [polypeptide binding]; other site 697284009339 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 697284009340 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 697284009341 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 697284009342 PYR/PP interface [polypeptide binding]; other site 697284009343 dimer interface [polypeptide binding]; other site 697284009344 TPP binding site [chemical binding]; other site 697284009345 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 697284009346 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 697284009347 TPP-binding site [chemical binding]; other site 697284009348 dimer interface [polypeptide binding]; other site 697284009349 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 697284009350 23S rRNA binding site [nucleotide binding]; other site 697284009351 L21 binding site [polypeptide binding]; other site 697284009352 L13 binding site [polypeptide binding]; other site 697284009353 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 697284009354 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 697284009355 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 697284009356 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 697284009357 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 697284009358 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 697284009359 DXD motif; other site 697284009360 monogalactosyldiacylglycerol synthase; Region: PLN02605 697284009361 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 697284009362 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 697284009363 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 697284009364 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 697284009365 Methyltransferase domain; Region: Methyltransf_31; pfam13847 697284009366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284009367 S-adenosylmethionine binding site [chemical binding]; other site 697284009368 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 697284009369 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 697284009370 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284009371 MULE transposase domain; Region: MULE; pfam10551 697284009372 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 697284009373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 697284009374 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 697284009375 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 697284009376 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 697284009377 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 697284009378 putative substrate binding site [chemical binding]; other site 697284009379 putative ATP binding site [chemical binding]; other site 697284009380 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 697284009381 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 697284009382 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 697284009383 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697284009384 RNA binding surface [nucleotide binding]; other site 697284009385 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 697284009386 probable active site [active] 697284009387 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 697284009388 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 697284009389 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284009390 MULE transposase domain; Region: MULE; pfam10551 697284009391 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 697284009392 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 697284009393 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 697284009394 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 697284009395 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 697284009396 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 697284009397 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 697284009398 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 697284009399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697284009400 Coenzyme A binding pocket [chemical binding]; other site 697284009401 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 697284009402 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 697284009403 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 697284009404 Walker A/P-loop; other site 697284009405 ATP binding site [chemical binding]; other site 697284009406 Q-loop/lid; other site 697284009407 ABC transporter signature motif; other site 697284009408 Walker B; other site 697284009409 D-loop; other site 697284009410 H-loop/switch region; other site 697284009411 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 697284009412 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 697284009413 ABC-ATPase subunit interface; other site 697284009414 dimer interface [polypeptide binding]; other site 697284009415 putative PBP binding regions; other site 697284009416 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 697284009417 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 697284009418 intersubunit interface [polypeptide binding]; other site 697284009419 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284009420 MULE transposase domain; Region: MULE; pfam10551 697284009421 FtsX-like permease family; Region: FtsX; pfam02687 697284009422 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697284009423 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 697284009424 Walker A/P-loop; other site 697284009425 ATP binding site [chemical binding]; other site 697284009426 Q-loop/lid; other site 697284009427 ABC transporter signature motif; other site 697284009428 Walker B; other site 697284009429 D-loop; other site 697284009430 H-loop/switch region; other site 697284009431 hypothetical protein; Provisional; Region: PRK06760; cl11698 697284009432 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 697284009433 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 697284009434 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 697284009435 putative dimer interface [polypeptide binding]; other site 697284009436 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 697284009437 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284009438 Walker A/P-loop; other site 697284009439 ATP binding site [chemical binding]; other site 697284009440 ABC transporter signature motif; other site 697284009441 Walker B; other site 697284009442 D-loop; other site 697284009443 H-loop/switch region; other site 697284009444 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 697284009445 Uncharacterized conserved protein [Function unknown]; Region: COG1739 697284009446 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 697284009447 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 697284009448 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 697284009449 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 697284009450 active site 697284009451 dimer interface [polypeptide binding]; other site 697284009452 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 697284009453 dimer interface [polypeptide binding]; other site 697284009454 active site 697284009455 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 697284009456 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 697284009457 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 697284009458 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 697284009459 TPP-binding site [chemical binding]; other site 697284009460 dimer interface [polypeptide binding]; other site 697284009461 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 697284009462 PYR/PP interface [polypeptide binding]; other site 697284009463 dimer interface [polypeptide binding]; other site 697284009464 TPP binding site [chemical binding]; other site 697284009465 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 697284009466 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 697284009467 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 697284009468 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 697284009469 putative active site [active] 697284009470 putative substrate binding site [chemical binding]; other site 697284009471 putative cosubstrate binding site; other site 697284009472 catalytic site [active] 697284009473 endonuclease IV; Provisional; Region: PRK01060 697284009474 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 697284009475 AP (apurinic/apyrimidinic) site pocket; other site 697284009476 DNA interaction; other site 697284009477 Metal-binding active site; metal-binding site 697284009478 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 697284009479 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 697284009480 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 697284009481 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 697284009482 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 697284009483 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 697284009484 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 697284009485 active site turn [active] 697284009486 phosphorylation site [posttranslational modification] 697284009487 Putative motility protein; Region: YjfB_motility; pfam14070 697284009488 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284009489 MULE transposase domain; Region: MULE; pfam10551 697284009490 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697284009491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284009492 active site 697284009493 phosphorylation site [posttranslational modification] 697284009494 intermolecular recognition site; other site 697284009495 dimerization interface [polypeptide binding]; other site 697284009496 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697284009497 DNA binding site [nucleotide binding] 697284009498 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 697284009499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697284009500 dimer interface [polypeptide binding]; other site 697284009501 phosphorylation site [posttranslational modification] 697284009502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284009503 ATP binding site [chemical binding]; other site 697284009504 Mg2+ binding site [ion binding]; other site 697284009505 G-X-G motif; other site 697284009506 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 697284009507 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 697284009508 NodB motif; other site 697284009509 active site 697284009510 catalytic site [active] 697284009511 Zn binding site [ion binding]; other site 697284009512 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 697284009513 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284009514 MULE transposase domain; Region: MULE; pfam10551 697284009515 Integrase core domain; Region: rve; pfam00665 697284009516 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 697284009517 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 697284009518 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 697284009519 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 697284009520 active site 697284009521 phosphorylation site [posttranslational modification] 697284009522 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 697284009523 HTH domain; Region: HTH_11; pfam08279 697284009524 PRD domain; Region: PRD; pfam00874 697284009525 PRD domain; Region: PRD; pfam00874 697284009526 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 697284009527 active site 697284009528 P-loop; other site 697284009529 phosphorylation site [posttranslational modification] 697284009530 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 697284009531 active site 697284009532 phosphorylation site [posttranslational modification] 697284009533 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 697284009534 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 697284009535 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 697284009536 active site 697284009537 P-loop; other site 697284009538 phosphorylation site [posttranslational modification] 697284009539 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 697284009540 active site 697284009541 catalytic site [active] 697284009542 substrate binding site [chemical binding]; other site 697284009543 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284009544 MULE transposase domain; Region: MULE; pfam10551 697284009545 Sec1 family; Region: Sec1; cl15415 697284009546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284009547 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 697284009548 Transcriptional regulators [Transcription]; Region: MarR; COG1846 697284009549 MarR family; Region: MarR_2; pfam12802 697284009550 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 697284009551 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 697284009552 Homeodomain-like domain; Region: HTH_23; pfam13384 697284009553 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284009554 MULE transposase domain; Region: MULE; pfam10551 697284009555 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 697284009556 ADP-ribosyltransferase exoenzyme; Region: ADPrib_exo_Tox; pfam03496 697284009557 active site 697284009558 conformational flexibility of ligand binding pocket; other site 697284009559 ADP-ribosylating toxin turn-turn motif; other site 697284009560 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284009561 MULE transposase domain; Region: MULE; pfam10551 697284009562 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 697284009563 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 697284009564 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 697284009565 active site 697284009566 RecT family; Region: RecT; cl04285 697284009567 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284009568 MULE transposase domain; Region: MULE; pfam10551 697284009569 DNA-sulfur modification-associated; Region: DndB; cl17621 697284009570 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284009571 MULE transposase domain; Region: MULE; pfam10551 697284009572 DNA-sulfur modification-associated; Region: DndB; cl17621 697284009573 Family description; Region: UvrD_C_2; pfam13538 697284009574 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 697284009575 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 697284009576 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 697284009577 glutaminase active site [active] 697284009578 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 697284009579 dimer interface [polypeptide binding]; other site 697284009580 active site 697284009581 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 697284009582 dimer interface [polypeptide binding]; other site 697284009583 active site 697284009584 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284009585 MULE transposase domain; Region: MULE; pfam10551 697284009586 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 697284009587 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 697284009588 active site 697284009589 substrate binding site [chemical binding]; other site 697284009590 metal binding site [ion binding]; metal-binding site 697284009591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 697284009592 YbbR-like protein; Region: YbbR; pfam07949 697284009593 Uncharacterized conserved protein [Function unknown]; Region: COG1624 697284009594 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 697284009595 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 697284009596 Putative zinc-finger; Region: zf-HC2; pfam13490 697284009597 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 697284009598 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697284009599 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697284009600 DNA binding residues [nucleotide binding] 697284009601 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 697284009602 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 697284009603 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284009604 MULE transposase domain; Region: MULE; pfam10551 697284009605 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 697284009606 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 697284009607 Subunit I/III interface [polypeptide binding]; other site 697284009608 Subunit III/IV interface [polypeptide binding]; other site 697284009609 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 697284009610 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 697284009611 D-pathway; other site 697284009612 Putative ubiquinol binding site [chemical binding]; other site 697284009613 Low-spin heme (heme b) binding site [chemical binding]; other site 697284009614 Putative water exit pathway; other site 697284009615 Binuclear center (heme o3/CuB) [ion binding]; other site 697284009616 K-pathway; other site 697284009617 Putative proton exit pathway; other site 697284009618 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 697284009619 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 697284009620 Integral membrane protein DUF95; Region: DUF95; pfam01944 697284009621 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 697284009622 Domain of unknown function DUF59; Region: DUF59; pfam01883 697284009623 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 697284009624 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 697284009625 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 697284009626 active site 697284009627 metal binding site [ion binding]; metal-binding site 697284009628 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 697284009629 ATP-sulfurylase; Region: ATPS; cd00517 697284009630 active site 697284009631 HXXH motif; other site 697284009632 flexible loop; other site 697284009633 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 697284009634 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 697284009635 Active Sites [active] 697284009636 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 697284009637 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 697284009638 NlpC/P60 family; Region: NLPC_P60; pfam00877 697284009639 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 697284009640 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 697284009641 23S rRNA interface [nucleotide binding]; other site 697284009642 L3 interface [polypeptide binding]; other site 697284009643 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 697284009644 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 697284009645 dimerization interface 3.5A [polypeptide binding]; other site 697284009646 active site 697284009647 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 697284009648 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 697284009649 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 697284009650 alphaNTD - beta interaction site [polypeptide binding]; other site 697284009651 alphaNTD homodimer interface [polypeptide binding]; other site 697284009652 alphaNTD - beta' interaction site [polypeptide binding]; other site 697284009653 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 697284009654 30S ribosomal protein S11; Validated; Region: PRK05309 697284009655 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 697284009656 30S ribosomal protein S13; Region: bact_S13; TIGR03631 697284009657 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 697284009658 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 697284009659 rRNA binding site [nucleotide binding]; other site 697284009660 predicted 30S ribosome binding site; other site 697284009661 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 697284009662 RNA binding site [nucleotide binding]; other site 697284009663 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 697284009664 active site 697284009665 adenylate kinase; Reviewed; Region: adk; PRK00279 697284009666 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 697284009667 AMP-binding site [chemical binding]; other site 697284009668 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 697284009669 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 697284009670 SecY translocase; Region: SecY; pfam00344 697284009671 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 697284009672 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 697284009673 23S rRNA binding site [nucleotide binding]; other site 697284009674 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 697284009675 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 697284009676 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 697284009677 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 697284009678 5S rRNA interface [nucleotide binding]; other site 697284009679 L27 interface [polypeptide binding]; other site 697284009680 23S rRNA interface [nucleotide binding]; other site 697284009681 L5 interface [polypeptide binding]; other site 697284009682 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 697284009683 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 697284009684 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 697284009685 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 697284009686 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 697284009687 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 697284009688 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 697284009689 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 697284009690 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 697284009691 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 697284009692 RNA binding site [nucleotide binding]; other site 697284009693 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 697284009694 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 697284009695 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 697284009696 23S rRNA interface [nucleotide binding]; other site 697284009697 putative translocon interaction site; other site 697284009698 signal recognition particle (SRP54) interaction site; other site 697284009699 L23 interface [polypeptide binding]; other site 697284009700 trigger factor interaction site; other site 697284009701 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 697284009702 23S rRNA interface [nucleotide binding]; other site 697284009703 5S rRNA interface [nucleotide binding]; other site 697284009704 putative antibiotic binding site [chemical binding]; other site 697284009705 L25 interface [polypeptide binding]; other site 697284009706 L27 interface [polypeptide binding]; other site 697284009707 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 697284009708 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 697284009709 G-X-X-G motif; other site 697284009710 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 697284009711 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 697284009712 putative translocon binding site; other site 697284009713 protein-rRNA interface [nucleotide binding]; other site 697284009714 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 697284009715 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 697284009716 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 697284009717 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 697284009718 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 697284009719 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 697284009720 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 697284009721 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 697284009722 elongation factor Tu; Reviewed; Region: PRK00049 697284009723 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 697284009724 G1 box; other site 697284009725 GEF interaction site [polypeptide binding]; other site 697284009726 GTP/Mg2+ binding site [chemical binding]; other site 697284009727 Switch I region; other site 697284009728 G2 box; other site 697284009729 G3 box; other site 697284009730 Switch II region; other site 697284009731 G4 box; other site 697284009732 G5 box; other site 697284009733 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 697284009734 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 697284009735 Antibiotic Binding Site [chemical binding]; other site 697284009736 elongation factor G; Reviewed; Region: PRK00007 697284009737 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 697284009738 G1 box; other site 697284009739 putative GEF interaction site [polypeptide binding]; other site 697284009740 GTP/Mg2+ binding site [chemical binding]; other site 697284009741 Switch I region; other site 697284009742 G2 box; other site 697284009743 G3 box; other site 697284009744 Switch II region; other site 697284009745 G4 box; other site 697284009746 G5 box; other site 697284009747 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 697284009748 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 697284009749 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 697284009750 30S ribosomal protein S7; Validated; Region: PRK05302 697284009751 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 697284009752 S17 interaction site [polypeptide binding]; other site 697284009753 S8 interaction site; other site 697284009754 16S rRNA interaction site [nucleotide binding]; other site 697284009755 streptomycin interaction site [chemical binding]; other site 697284009756 23S rRNA interaction site [nucleotide binding]; other site 697284009757 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 697284009758 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 697284009759 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 697284009760 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 697284009761 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 697284009762 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 697284009763 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 697284009764 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 697284009765 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 697284009766 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 697284009767 G-loop; other site 697284009768 DNA binding site [nucleotide binding] 697284009769 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 697284009770 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 697284009771 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 697284009772 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 697284009773 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 697284009774 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 697284009775 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 697284009776 RPB10 interaction site [polypeptide binding]; other site 697284009777 RPB1 interaction site [polypeptide binding]; other site 697284009778 RPB11 interaction site [polypeptide binding]; other site 697284009779 RPB3 interaction site [polypeptide binding]; other site 697284009780 RPB12 interaction site [polypeptide binding]; other site 697284009781 Methyltransferase domain; Region: Methyltransf_31; pfam13847 697284009782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284009783 S-adenosylmethionine binding site [chemical binding]; other site 697284009784 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 697284009785 core dimer interface [polypeptide binding]; other site 697284009786 peripheral dimer interface [polypeptide binding]; other site 697284009787 L10 interface [polypeptide binding]; other site 697284009788 L11 interface [polypeptide binding]; other site 697284009789 putative EF-Tu interaction site [polypeptide binding]; other site 697284009790 putative EF-G interaction site [polypeptide binding]; other site 697284009791 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 697284009792 23S rRNA interface [nucleotide binding]; other site 697284009793 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 697284009794 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 697284009795 mRNA/rRNA interface [nucleotide binding]; other site 697284009796 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 697284009797 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 697284009798 23S rRNA interface [nucleotide binding]; other site 697284009799 L7/L12 interface [polypeptide binding]; other site 697284009800 putative thiostrepton binding site; other site 697284009801 L25 interface [polypeptide binding]; other site 697284009802 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 697284009803 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 697284009804 putative homodimer interface [polypeptide binding]; other site 697284009805 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 697284009806 heterodimer interface [polypeptide binding]; other site 697284009807 homodimer interface [polypeptide binding]; other site 697284009808 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 697284009809 RNA polymerase factor sigma-70; Validated; Region: PRK08295 697284009810 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697284009811 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 697284009812 YacP-like NYN domain; Region: NYN_YacP; pfam05991 697284009813 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 697284009814 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 697284009815 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 697284009816 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 697284009817 dimerization interface [polypeptide binding]; other site 697284009818 active site 697284009819 metal binding site [ion binding]; metal-binding site 697284009820 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 697284009821 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 697284009822 active site 697284009823 HIGH motif; other site 697284009824 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 697284009825 KMSKS motif; other site 697284009826 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 697284009827 tRNA binding surface [nucleotide binding]; other site 697284009828 anticodon binding site; other site 697284009829 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 697284009830 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 697284009831 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 697284009832 trimer interface [polypeptide binding]; other site 697284009833 active site 697284009834 substrate binding site [chemical binding]; other site 697284009835 CoA binding site [chemical binding]; other site 697284009836 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 697284009837 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 697284009838 active site 697284009839 HIGH motif; other site 697284009840 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 697284009841 active site 697284009842 KMSKS motif; other site 697284009843 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 697284009844 homotrimer interaction site [polypeptide binding]; other site 697284009845 zinc binding site [ion binding]; other site 697284009846 CDP-binding sites; other site 697284009847 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 697284009848 substrate binding site; other site 697284009849 dimer interface; other site 697284009850 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 697284009851 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 697284009852 putative active site [active] 697284009853 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 697284009854 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 697284009855 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 697284009856 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 697284009857 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 697284009858 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 697284009859 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 697284009860 DNA repair protein RadA; Provisional; Region: PRK11823 697284009861 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 697284009862 Walker A motif/ATP binding site; other site 697284009863 ATP binding site [chemical binding]; other site 697284009864 Walker B motif; other site 697284009865 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 697284009866 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 697284009867 Clp amino terminal domain; Region: Clp_N; pfam02861 697284009868 Clp amino terminal domain; Region: Clp_N; pfam02861 697284009869 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697284009870 Walker A motif; other site 697284009871 ATP binding site [chemical binding]; other site 697284009872 Walker B motif; other site 697284009873 arginine finger; other site 697284009874 UvrB/uvrC motif; Region: UVR; pfam02151 697284009875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697284009876 Walker A motif; other site 697284009877 ATP binding site [chemical binding]; other site 697284009878 Walker B motif; other site 697284009879 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 697284009880 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 697284009881 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 697284009882 ADP binding site [chemical binding]; other site 697284009883 phosphagen binding site; other site 697284009884 substrate specificity loop; other site 697284009885 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 697284009886 UvrB/uvrC motif; Region: UVR; pfam02151 697284009887 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 697284009888 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 697284009889 recombination protein RecR; Reviewed; Region: recR; PRK00076 697284009890 RecR protein; Region: RecR; pfam02132 697284009891 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 697284009892 putative active site [active] 697284009893 putative metal-binding site [ion binding]; other site 697284009894 tetramer interface [polypeptide binding]; other site 697284009895 hypothetical protein; Validated; Region: PRK00153 697284009896 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 697284009897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697284009898 Walker A motif; other site 697284009899 ATP binding site [chemical binding]; other site 697284009900 Walker B motif; other site 697284009901 arginine finger; other site 697284009902 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 697284009903 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 697284009904 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 697284009905 putative active site [active] 697284009906 heme pocket [chemical binding]; other site 697284009907 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 697284009908 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 697284009909 putative active site [active] 697284009910 heme pocket [chemical binding]; other site 697284009911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697284009912 dimer interface [polypeptide binding]; other site 697284009913 phosphorylation site [posttranslational modification] 697284009914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284009915 ATP binding site [chemical binding]; other site 697284009916 Mg2+ binding site [ion binding]; other site 697284009917 G-X-G motif; other site 697284009918 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 697284009919 transcription termination factor Rho; Provisional; Region: rho; PRK09376 697284009920 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 697284009921 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 697284009922 RNA binding site [nucleotide binding]; other site 697284009923 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 697284009924 multimer interface [polypeptide binding]; other site 697284009925 Walker A motif; other site 697284009926 ATP binding site [chemical binding]; other site 697284009927 Walker B motif; other site 697284009928 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 697284009929 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 697284009930 hinge; other site 697284009931 active site 697284009932 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 697284009933 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 697284009934 intersubunit interface [polypeptide binding]; other site 697284009935 active site 697284009936 zinc binding site [ion binding]; other site 697284009937 Na+ binding site [ion binding]; other site 697284009938 Response regulator receiver domain; Region: Response_reg; pfam00072 697284009939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284009940 active site 697284009941 phosphorylation site [posttranslational modification] 697284009942 intermolecular recognition site; other site 697284009943 dimerization interface [polypeptide binding]; other site 697284009944 CTP synthetase; Validated; Region: pyrG; PRK05380 697284009945 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 697284009946 Catalytic site [active] 697284009947 active site 697284009948 UTP binding site [chemical binding]; other site 697284009949 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 697284009950 active site 697284009951 putative oxyanion hole; other site 697284009952 catalytic triad [active] 697284009953 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 697284009954 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 697284009955 active site 697284009956 catalytic residues [active] 697284009957 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 697284009958 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 697284009959 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 697284009960 active site 697284009961 HIGH motif; other site 697284009962 KMSK motif region; other site 697284009963 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 697284009964 tRNA binding surface [nucleotide binding]; other site 697284009965 anticodon binding site; other site 697284009966 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 697284009967 agmatinase; Region: agmatinase; TIGR01230 697284009968 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 697284009969 putative active site [active] 697284009970 Mn binding site [ion binding]; other site 697284009971 spermidine synthase; Provisional; Region: PRK00811 697284009972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284009973 Transglycosylase; Region: Transgly; pfam00912 697284009974 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 697284009975 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 697284009976 YwhD family; Region: YwhD; pfam08741 697284009977 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 697284009978 Zn binding site [ion binding]; other site 697284009979 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 697284009980 active site residue [active] 697284009981 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 697284009982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697284009983 Coenzyme A binding pocket [chemical binding]; other site 697284009984 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 697284009985 MarR family; Region: MarR; pfam01047 697284009986 Major Facilitator Superfamily; Region: MFS_1; pfam07690 697284009987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284009988 putative substrate translocation pore; other site 697284009989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284009990 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 697284009991 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 697284009992 SNF2 Helicase protein; Region: DUF3670; pfam12419 697284009993 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 697284009994 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697284009995 ATP binding site [chemical binding]; other site 697284009996 putative Mg++ binding site [ion binding]; other site 697284009997 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697284009998 nucleotide binding region [chemical binding]; other site 697284009999 ATP-binding site [chemical binding]; other site 697284010000 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 697284010001 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 697284010002 dimer interface [polypeptide binding]; other site 697284010003 putative anticodon binding site; other site 697284010004 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 697284010005 motif 1; other site 697284010006 active site 697284010007 motif 2; other site 697284010008 motif 3; other site 697284010009 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 697284010010 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 697284010011 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 697284010012 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 697284010013 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 697284010014 FMN binding site [chemical binding]; other site 697284010015 active site 697284010016 catalytic residues [active] 697284010017 substrate binding site [chemical binding]; other site 697284010018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697284010019 non-specific DNA binding site [nucleotide binding]; other site 697284010020 salt bridge; other site 697284010021 sequence-specific DNA binding site [nucleotide binding]; other site 697284010022 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 697284010023 catalytic center binding site [active] 697284010024 ATP binding site [chemical binding]; other site 697284010025 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 697284010026 homooctamer interface [polypeptide binding]; other site 697284010027 active site 697284010028 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 697284010029 dihydropteroate synthase; Region: DHPS; TIGR01496 697284010030 substrate binding pocket [chemical binding]; other site 697284010031 dimer interface [polypeptide binding]; other site 697284010032 inhibitor binding site; inhibition site 697284010033 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 697284010034 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 697284010035 homodimer interface [polypeptide binding]; other site 697284010036 substrate-cofactor binding pocket; other site 697284010037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284010038 catalytic residue [active] 697284010039 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 697284010040 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 697284010041 glutamine binding [chemical binding]; other site 697284010042 catalytic triad [active] 697284010043 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 697284010044 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 697284010045 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 697284010046 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 697284010047 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 697284010048 dimer interface [polypeptide binding]; other site 697284010049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284010050 catalytic residue [active] 697284010051 SurA N-terminal domain; Region: SurA_N_3; cl07813 697284010052 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 697284010053 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 697284010054 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 697284010055 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 697284010056 dimerization interface [polypeptide binding]; other site 697284010057 domain crossover interface; other site 697284010058 redox-dependent activation switch; other site 697284010059 pantothenate kinase; Reviewed; Region: PRK13318 697284010060 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 697284010061 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 697284010062 dimerization interface [polypeptide binding]; other site 697284010063 active site 697284010064 Quinolinate synthetase A protein; Region: NadA; pfam02445 697284010065 FtsH Extracellular; Region: FtsH_ext; pfam06480 697284010066 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 697284010067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697284010068 Walker A motif; other site 697284010069 ATP binding site [chemical binding]; other site 697284010070 Walker B motif; other site 697284010071 arginine finger; other site 697284010072 Peptidase family M41; Region: Peptidase_M41; pfam01434 697284010073 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697284010074 active site 697284010075 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 697284010076 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 697284010077 Ligand Binding Site [chemical binding]; other site 697284010078 TilS substrate C-terminal domain; Region: TilS_C; smart00977 697284010079 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 697284010080 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 697284010081 active site 697284010082 ATP binding site [chemical binding]; other site 697284010083 substrate binding site [chemical binding]; other site 697284010084 activation loop (A-loop); other site 697284010085 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 697284010086 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 697284010087 metal ion-dependent adhesion site (MIDAS); other site 697284010088 stage II sporulation protein E; Region: spore_II_E; TIGR02865 697284010089 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 697284010090 hypothetical protein; Provisional; Region: PRK08582 697284010091 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 697284010092 RNA binding site [nucleotide binding]; other site 697284010093 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 697284010094 Septum formation initiator; Region: DivIC; pfam04977 697284010095 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 697284010096 YabP family; Region: YabP; cl06766 697284010097 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697284010098 RNA binding surface [nucleotide binding]; other site 697284010099 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 697284010100 IHF dimer interface [polypeptide binding]; other site 697284010101 IHF - DNA interface [nucleotide binding]; other site 697284010102 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 697284010103 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 697284010104 putative SAM binding site [chemical binding]; other site 697284010105 putative homodimer interface [polypeptide binding]; other site 697284010106 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 697284010107 homodimer interface [polypeptide binding]; other site 697284010108 metal binding site [ion binding]; metal-binding site 697284010109 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 697284010110 homodimer interface [polypeptide binding]; other site 697284010111 active site 697284010112 putative chemical substrate binding site [chemical binding]; other site 697284010113 metal binding site [ion binding]; metal-binding site 697284010114 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 697284010115 stage V sporulation protein T; Region: spore_V_T; TIGR02851 697284010116 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 697284010117 GAF domain; Region: GAF; cl17456 697284010118 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 697284010119 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 697284010120 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 697284010121 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697284010122 ATP binding site [chemical binding]; other site 697284010123 putative Mg++ binding site [ion binding]; other site 697284010124 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697284010125 nucleotide binding region [chemical binding]; other site 697284010126 ATP-binding site [chemical binding]; other site 697284010127 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 697284010128 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 697284010129 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 697284010130 putative active site [active] 697284010131 catalytic residue [active] 697284010132 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284010133 MULE transposase domain; Region: MULE; pfam10551 697284010134 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 697284010135 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 697284010136 5S rRNA interface [nucleotide binding]; other site 697284010137 CTC domain interface [polypeptide binding]; other site 697284010138 L16 interface [polypeptide binding]; other site 697284010139 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 697284010140 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 697284010141 Substrate binding site; other site 697284010142 Mg++ binding site; other site 697284010143 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 697284010144 active site 697284010145 substrate binding site [chemical binding]; other site 697284010146 CoA binding site [chemical binding]; other site 697284010147 regulatory protein SpoVG; Reviewed; Region: PRK13259 697284010148 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 697284010149 homotrimer interaction site [polypeptide binding]; other site 697284010150 putative active site [active] 697284010151 pur operon repressor; Provisional; Region: PRK09213 697284010152 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 697284010153 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 697284010154 active site 697284010155 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 697284010156 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 697284010157 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 697284010158 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 697284010159 YabG peptidase U57; Region: Peptidase_U57; cl05250 697284010160 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 697284010161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284010162 S-adenosylmethionine binding site [chemical binding]; other site 697284010163 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 697284010164 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 697284010165 putative active site [active] 697284010166 putative metal binding site [ion binding]; other site 697284010167 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 697284010168 Domain of unknown function (DUF348); Region: DUF348; pfam03990 697284010169 Domain of unknown function (DUF348); Region: DUF348; pfam03990 697284010170 G5 domain; Region: G5; pfam07501 697284010171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 697284010172 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 697284010173 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 697284010174 Walker A/P-loop; other site 697284010175 ATP binding site [chemical binding]; other site 697284010176 Q-loop/lid; other site 697284010177 ABC transporter signature motif; other site 697284010178 Walker B; other site 697284010179 D-loop; other site 697284010180 H-loop/switch region; other site 697284010181 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 697284010182 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 697284010183 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 697284010184 active site 697284010185 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 697284010186 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697284010187 Zn2+ binding site [ion binding]; other site 697284010188 Mg2+ binding site [ion binding]; other site 697284010189 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 697284010190 Predicted methyltransferases [General function prediction only]; Region: COG0313 697284010191 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 697284010192 putative SAM binding site [chemical binding]; other site 697284010193 putative homodimer interface [polypeptide binding]; other site 697284010194 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 697284010195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697284010196 S-adenosylmethionine binding site [chemical binding]; other site 697284010197 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 697284010198 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 697284010199 DNA polymerase III subunit delta'; Validated; Region: PRK08058 697284010200 DNA polymerase III subunit delta'; Validated; Region: PRK08485 697284010201 Protein of unknown function (DUF327); Region: DUF327; pfam03885 697284010202 Protein of unknown function (DUF970); Region: DUF970; pfam06153 697284010203 thymidylate kinase; Validated; Region: tmk; PRK00698 697284010204 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 697284010205 TMP-binding site; other site 697284010206 ATP-binding site [chemical binding]; other site 697284010207 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 697284010208 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 697284010209 homodimer interface [polypeptide binding]; other site 697284010210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284010211 catalytic residue [active] 697284010212 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 697284010213 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 697284010214 Predicted amidohydrolase [General function prediction only]; Region: COG0388 697284010215 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 697284010216 putative active site [active] 697284010217 catalytic triad [active] 697284010218 putative dimer interface [polypeptide binding]; other site 697284010219 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 697284010220 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 697284010221 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 697284010222 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 697284010223 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 697284010224 NAD binding site [chemical binding]; other site 697284010225 homodimer interface [polypeptide binding]; other site 697284010226 active site 697284010227 substrate binding site [chemical binding]; other site 697284010228 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 697284010229 galactokinase; Provisional; Region: PRK05322 697284010230 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 697284010231 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 697284010232 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 697284010233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697284010234 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 697284010235 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697284010236 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 697284010237 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 697284010238 TM-ABC transporter signature motif; other site 697284010239 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 697284010240 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 697284010241 TM-ABC transporter signature motif; other site 697284010242 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 697284010243 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 697284010244 Walker A/P-loop; other site 697284010245 ATP binding site [chemical binding]; other site 697284010246 Q-loop/lid; other site 697284010247 ABC transporter signature motif; other site 697284010248 Walker B; other site 697284010249 D-loop; other site 697284010250 H-loop/switch region; other site 697284010251 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 697284010252 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 697284010253 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 697284010254 ligand binding site [chemical binding]; other site 697284010255 threonine dehydratase; Validated; Region: PRK08639 697284010256 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 697284010257 tetramer interface [polypeptide binding]; other site 697284010258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697284010259 catalytic residue [active] 697284010260 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 697284010261 putative Ile/Val binding site [chemical binding]; other site 697284010262 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284010263 MULE transposase domain; Region: MULE; pfam10551 697284010264 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 697284010265 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 697284010266 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 697284010267 Walker A/P-loop; other site 697284010268 ATP binding site [chemical binding]; other site 697284010269 Q-loop/lid; other site 697284010270 ABC transporter signature motif; other site 697284010271 Walker B; other site 697284010272 D-loop; other site 697284010273 H-loop/switch region; other site 697284010274 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 697284010275 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 697284010276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284010277 Walker A/P-loop; other site 697284010278 ATP binding site [chemical binding]; other site 697284010279 Q-loop/lid; other site 697284010280 ABC transporter signature motif; other site 697284010281 Walker B; other site 697284010282 D-loop; other site 697284010283 H-loop/switch region; other site 697284010284 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 697284010285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284010286 Walker A/P-loop; other site 697284010287 ATP binding site [chemical binding]; other site 697284010288 Q-loop/lid; other site 697284010289 ABC transporter signature motif; other site 697284010290 Walker B; other site 697284010291 D-loop; other site 697284010292 H-loop/switch region; other site 697284010293 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284010294 MULE transposase domain; Region: MULE; pfam10551 697284010295 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284010296 MULE transposase domain; Region: MULE; pfam10551 697284010297 circular bacteriocin, circularin A/uberolysin family; Region: circ_ocin_uber; TIGR03651 697284010298 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 697284010299 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 697284010300 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 697284010301 Uncharacterized conserved protein [Function unknown]; Region: COG1801 697284010302 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 697284010303 metal-dependent hydrolase; Provisional; Region: PRK00685 697284010304 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 697284010305 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 697284010306 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 697284010307 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 697284010308 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 697284010309 dimer interface [polypeptide binding]; other site 697284010310 PYR/PP interface [polypeptide binding]; other site 697284010311 TPP binding site [chemical binding]; other site 697284010312 substrate binding site [chemical binding]; other site 697284010313 FliW protein; Region: FliW; cl00740 697284010314 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 697284010315 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 697284010316 TPP-binding site [chemical binding]; other site 697284010317 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 697284010318 pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028 697284010319 4Fe-4S binding domain; Region: Fer4; pfam00037 697284010320 YwiC-like protein; Region: YwiC; pfam14256 697284010321 Predicted membrane protein [Function unknown]; Region: COG2855 697284010322 amino acid transporter; Region: 2A0306; TIGR00909 697284010323 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284010324 MULE transposase domain; Region: MULE; pfam10551 697284010325 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 697284010326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284010327 Q-loop/lid; other site 697284010328 ABC transporter signature motif; other site 697284010329 Walker B; other site 697284010330 D-loop; other site 697284010331 H-loop/switch region; other site 697284010332 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 697284010333 Walker A/P-loop; other site 697284010334 ATP binding site [chemical binding]; other site 697284010335 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 697284010336 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 697284010337 HlyD family secretion protein; Region: HlyD_3; pfam13437 697284010338 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697284010339 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 697284010340 Walker A/P-loop; other site 697284010341 ATP binding site [chemical binding]; other site 697284010342 Q-loop/lid; other site 697284010343 ABC transporter signature motif; other site 697284010344 Walker B; other site 697284010345 D-loop; other site 697284010346 H-loop/switch region; other site 697284010347 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 697284010348 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 697284010349 FtsX-like permease family; Region: FtsX; pfam02687 697284010350 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 697284010351 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 697284010352 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 697284010353 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 697284010354 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 697284010355 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 697284010356 [4Fe-4S] binding site [ion binding]; other site 697284010357 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 697284010358 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 697284010359 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 697284010360 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 697284010361 molybdopterin cofactor binding site; other site 697284010362 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 697284010363 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 697284010364 GTP binding site; other site 697284010365 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 697284010366 Walker A motif; other site 697284010367 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 697284010368 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 697284010369 dimer interface [polypeptide binding]; other site 697284010370 putative functional site; other site 697284010371 putative MPT binding site; other site 697284010372 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 697284010373 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697284010374 FeS/SAM binding site; other site 697284010375 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 697284010376 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 697284010377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284010378 putative substrate translocation pore; other site 697284010379 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 697284010380 GAF domain; Region: GAF_2; pfam13185 697284010381 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 697284010382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697284010383 active site 697284010384 phosphorylation site [posttranslational modification] 697284010385 intermolecular recognition site; other site 697284010386 dimerization interface [polypeptide binding]; other site 697284010387 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 697284010388 DNA binding residues [nucleotide binding] 697284010389 dimerization interface [polypeptide binding]; other site 697284010390 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 697284010391 Histidine kinase; Region: HisKA_3; pfam07730 697284010392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697284010393 ATP binding site [chemical binding]; other site 697284010394 Mg2+ binding site [ion binding]; other site 697284010395 G-X-G motif; other site 697284010396 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 697284010397 MoaE interaction surface [polypeptide binding]; other site 697284010398 MoeB interaction surface [polypeptide binding]; other site 697284010399 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 697284010400 MoaE homodimer interface [polypeptide binding]; other site 697284010401 MoaD interaction [polypeptide binding]; other site 697284010402 active site residues [active] 697284010403 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 697284010404 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 697284010405 ATP binding site [chemical binding]; other site 697284010406 substrate interface [chemical binding]; other site 697284010407 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 697284010408 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 697284010409 active site 697284010410 HIGH motif; other site 697284010411 nucleotide binding site [chemical binding]; other site 697284010412 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 697284010413 KMSKS motif; other site 697284010414 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 697284010415 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 697284010416 dimer interface [polypeptide binding]; other site 697284010417 substrate binding site [chemical binding]; other site 697284010418 ATP binding site [chemical binding]; other site 697284010419 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 697284010420 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 697284010421 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 697284010422 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 697284010423 EamA-like transporter family; Region: EamA; pfam00892 697284010424 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 697284010425 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 697284010426 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 697284010427 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 697284010428 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 697284010429 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697284010430 FeS/SAM binding site; other site 697284010431 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 697284010432 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 697284010433 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 697284010434 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284010435 MULE transposase domain; Region: MULE; pfam10551 697284010436 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 697284010437 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 697284010438 Walker A/P-loop; other site 697284010439 ATP binding site [chemical binding]; other site 697284010440 Q-loop/lid; other site 697284010441 ABC transporter signature motif; other site 697284010442 Walker B; other site 697284010443 D-loop; other site 697284010444 H-loop/switch region; other site 697284010445 Predicted membrane protein [Function unknown]; Region: COG1511 697284010446 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 697284010447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697284010448 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 697284010449 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 697284010450 ATP binding site [chemical binding]; other site 697284010451 Mg++ binding site [ion binding]; other site 697284010452 motif III; other site 697284010453 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697284010454 nucleotide binding region [chemical binding]; other site 697284010455 ATP-binding site [chemical binding]; other site 697284010456 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 697284010457 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697284010458 Zn2+ binding site [ion binding]; other site 697284010459 Mg2+ binding site [ion binding]; other site 697284010460 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 697284010461 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 697284010462 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 697284010463 active site 697284010464 tetramer interface [polypeptide binding]; other site 697284010465 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697284010466 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697284010467 DNA binding site [nucleotide binding] 697284010468 domain linker motif; other site 697284010469 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 697284010470 dimerization interface [polypeptide binding]; other site 697284010471 ligand binding site [chemical binding]; other site 697284010472 sodium binding site [ion binding]; other site 697284010473 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 697284010474 Domain of unknown function DUF20; Region: UPF0118; pfam01594 697284010475 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284010476 MULE transposase domain; Region: MULE; pfam10551 697284010477 Coat F domain; Region: Coat_F; pfam07875 697284010478 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 697284010479 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 697284010480 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 697284010481 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 697284010482 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 697284010483 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 697284010484 Walker A/P-loop; other site 697284010485 ATP binding site [chemical binding]; other site 697284010486 Q-loop/lid; other site 697284010487 ABC transporter signature motif; other site 697284010488 Walker B; other site 697284010489 D-loop; other site 697284010490 H-loop/switch region; other site 697284010491 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 697284010492 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 697284010493 Walker A/P-loop; other site 697284010494 ATP binding site [chemical binding]; other site 697284010495 Q-loop/lid; other site 697284010496 ABC transporter signature motif; other site 697284010497 Walker B; other site 697284010498 D-loop; other site 697284010499 H-loop/switch region; other site 697284010500 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284010501 MULE transposase domain; Region: MULE; pfam10551 697284010502 Predicted transcriptional regulators [Transcription]; Region: COG1695 697284010503 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 697284010504 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 697284010505 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 697284010506 potential catalytic triad [active] 697284010507 conserved cys residue [active] 697284010508 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 697284010509 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 697284010510 dimer interface [polypeptide binding]; other site 697284010511 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 697284010512 ssDNA binding site [nucleotide binding]; other site 697284010513 tetramer (dimer of dimers) interface [polypeptide binding]; other site 697284010514 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 697284010515 YjzC-like protein; Region: YjzC; pfam14168 697284010516 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 697284010517 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 697284010518 Mechanosensitive ion channel; Region: MS_channel; pfam00924 697284010519 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 697284010520 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 697284010521 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 697284010522 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 697284010523 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697284010524 catalytic residue [active] 697284010525 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 697284010526 ParB-like nuclease domain; Region: ParB; smart00470 697284010527 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 697284010528 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 697284010529 P-loop; other site 697284010530 Magnesium ion binding site [ion binding]; other site 697284010531 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 697284010532 Magnesium ion binding site [ion binding]; other site 697284010533 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 697284010534 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697284010535 MULE transposase domain; Region: MULE; pfam10551 697284010536 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 697284010537 ParB-like nuclease domain; Region: ParB; smart00470 697284010538 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 697284010539 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 697284010540 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 697284010541 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 697284010542 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 697284010543 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 697284010544 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 697284010545 trmE is a tRNA modification GTPase; Region: trmE; cd04164 697284010546 G1 box; other site 697284010547 GTP/Mg2+ binding site [chemical binding]; other site 697284010548 Switch I region; other site 697284010549 G2 box; other site 697284010550 Switch II region; other site 697284010551 G3 box; other site 697284010552 G4 box; other site 697284010553 G5 box; other site 697284010554 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 697284010555 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 697284010556 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 697284010557 G-X-X-G motif; other site 697284010558 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 697284010559 RxxxH motif; other site 697284010560 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 697284010561 ribonuclease P; Reviewed; Region: rnpA; PRK00499 697284010562 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 697284010563 Replication initiation factor; Region: Rep_trans; pfam02486 697284010564 AmiB activator; Provisional; Region: PRK11637 697284010565 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 697284010566 Interdomain contacts; other site 697284010567 Cytokine receptor motif; other site 697284010568 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 697284010569 Interdomain contacts; other site 697284010570 Cytokine receptor motif; other site 697284010571 Dynein heavy chain and region D6 of dynein motor; Region: Dynein_heavy; pfam03028 697284010572 Zonular occludens toxin (Zot); Region: Zot; cl17485